BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens] (508 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens] 1053 0.0 gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens] 1017 0.0 gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens] 1007 0.0 gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens] 883 0.0 gi|62945417 dystrophia myotonica-containing WD repeat motif prot... 517 e-146 gi|13376840 WD repeat domain 61 [Homo sapiens] 59 1e-08 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 56 7e-08 gi|26665869 WD repeat domain 51B [Homo sapiens] 55 2e-07 gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 53 6e-07 gi|19913369 transducin beta-like 3 [Homo sapiens] 53 7e-07 gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 52 1e-06 gi|16554629 WD repeat domain 5 [Homo sapiens] 51 2e-06 gi|16554627 WD repeat domain 5 [Homo sapiens] 51 2e-06 gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 51 2e-06 gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 51 2e-06 gi|5174447 guanine nucleotide binding protein (G protein), beta ... 51 3e-06 gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 49 8e-06 gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 49 8e-06 gi|148727341 serine/threonine kinase receptor associated protein... 49 1e-05 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 48 2e-05 gi|113865883 WD repeat domain 38 [Homo sapiens] 48 2e-05 gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 48 2e-05 gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 48 2e-05 gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 48 2e-05 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 47 3e-05 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 47 5e-05 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 47 5e-05 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 47 5e-05 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 46 7e-05 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 46 7e-05 >gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens] Length = 508 Score = 1053 bits (2724), Expect = 0.0 Identities = 508/508 (100%), Positives = 508/508 (100%) Query: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG Sbjct: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60 Query: 61 NGDRLCFNVGRELYFYIYKGVRKRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEH 120 NGDRLCFNVGRELYFYIYKGVRKRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEH Sbjct: 61 NGDRLCFNVGRELYFYIYKGVRKRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEH 120 Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD Sbjct: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180 Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH Sbjct: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240 Query: 241 GHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR 300 GHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR Sbjct: 241 GHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR 300 Query: 301 PVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTP 360 PVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTP Sbjct: 301 PVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTP 360 Query: 361 GNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRN 420 GNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRN Sbjct: 361 GNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRN 420 Query: 421 HSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIF 480 HSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIF Sbjct: 421 HSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIF 480 Query: 481 LEDCIVTACQEGFICTWGRPGKVVSFNP 508 LEDCIVTACQEGFICTWGRPGKVVSFNP Sbjct: 481 LEDCIVTACQEGFICTWGRPGKVVSFNP 508 >gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens] Length = 569 Score = 1017 bits (2629), Expect = 0.0 Identities = 505/569 (88%), Positives = 507/569 (89%), Gaps = 61/569 (10%) Query: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG Sbjct: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60 Query: 61 NGDRLCFNVGRELYFYI------------------YKGVR-------------------- 82 NGDRLCFNVGRELYFYI YKG + Sbjct: 61 NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120 Query: 83 -----------------------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 119 +RLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE Sbjct: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180 Query: 120 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 179 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ Sbjct: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240 Query: 180 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 239 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG Sbjct: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300 Query: 240 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 299 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS Sbjct: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360 Query: 300 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 359 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT Sbjct: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420 Query: 360 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 419 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR Sbjct: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480 Query: 420 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 479 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI Sbjct: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540 Query: 480 FLEDCIVTACQEGFICTWGRPGKVVSFNP 508 FLEDCIVTACQEGFICTWGRPGKVVSFNP Sbjct: 541 FLEDCIVTACQEGFICTWGRPGKVVSFNP 569 >gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens] Length = 581 Score = 1007 bits (2604), Expect = 0.0 Identities = 501/568 (88%), Positives = 504/568 (88%), Gaps = 61/568 (10%) Query: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG Sbjct: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60 Query: 61 NGDRLCFNVGRELYFYI------------------YKGVR-------------------- 82 NGDRLCFNVGRELYFYI YKG + Sbjct: 61 NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120 Query: 83 -----------------------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 119 +RLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE Sbjct: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180 Query: 120 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 179 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ Sbjct: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240 Query: 180 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 239 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG Sbjct: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300 Query: 240 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 299 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS Sbjct: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360 Query: 300 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 359 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT Sbjct: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420 Query: 360 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 419 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR Sbjct: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480 Query: 420 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 479 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI Sbjct: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540 Query: 480 FLEDCIVTACQEGFICTWGRPGKVVSFN 507 FLEDCIVTACQEGFICTWGRPGKV S + Sbjct: 541 FLEDCIVTACQEGFICTWGRPGKVGSLS 568 >gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens] Length = 445 Score = 883 bits (2282), Expect = 0.0 Identities = 425/426 (99%), Positives = 426/426 (100%) Query: 83 KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHT 142 +RLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHT Sbjct: 20 ERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHT 79 Query: 143 CKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG 202 CKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG Sbjct: 80 CKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG 139 Query: 203 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD 262 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD Sbjct: 140 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD 199 Query: 263 PMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDL 322 PMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDL Sbjct: 200 PMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDL 259 Query: 323 TEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNA 382 TEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNA Sbjct: 260 TEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNA 319 Query: 383 GSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKT 442 GSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKT Sbjct: 320 GSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKT 379 Query: 443 DPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGK 502 DPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGK Sbjct: 380 DPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGK 439 Query: 503 VVSFNP 508 VVSFNP Sbjct: 440 VVSFNP 445 >gi|62945417 dystrophia myotonica-containing WD repeat motif protein [Homo sapiens] Length = 674 Score = 517 bits (1331), Expect = e-146 Identities = 296/621 (47%), Positives = 353/621 (56%), Gaps = 138/621 (22%) Query: 12 EIKTQFTTREGLYKLLPHSEYSR---------------PNRVPFNSQGSNP--------- 47 EIK+QF TREG YKLLP +R P P + S P Sbjct: 21 EIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSP 80 Query: 48 -------------VRVSFVNLN--DQSG-------------NGDRLCFNVGRELYFY--- 76 VR+S V L D +G GDR+CFN+GRELYFY Sbjct: 81 PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGC 140 Query: 77 ------------------IYKGVR------------------------------------ 82 IYKG + Sbjct: 141 CRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKD 200 Query: 83 -------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG 135 +RLIDK++VT +KW+P SESLFL +H+SG++YLYNV H C + P Y LLKQG Sbjct: 201 TSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQG 260 Query: 136 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 195 E F+V+ KSK+ RNPL KW VGEG LNEFAFSPDG+ LACVSQDG LRVF+FDS+ L G Sbjct: 261 EGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRG 320 Query: 196 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 255 MKSYFGGLLCVCWSPDG+Y+VTGGEDDLVTVWSF + RV+ARGHGHKSWV+ VAFDPYT Sbjct: 321 LMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYT 380 Query: 256 TSVEE-----GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGS 310 T EE G E SG +E+ + A T S S + S+TYRFGS Sbjct: 381 TRAEEAATAAGADGERSGEEEEEE-------PEAAGTGSAGGAPLSPLPKAGSITYRFGS 433 Query: 311 VGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPR 370 GQDTQ CLWDLTED+L+PH PL+R RT T P A S+ PG +P L R Sbjct: 434 AGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-PLPRSLSR 492 Query: 371 SNSLPHSA-VSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHIS-- 427 SNSLPH A AG + + +FATL+L +R++R EK+HKR HS+G+IS Sbjct: 493 SNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRG 552 Query: 428 ------SKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFL 481 S V +++ DPAK LGT LCPR+ +VPLLEPL+CKKIA ERLTVL+FL Sbjct: 553 GSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFL 612 Query: 482 EDCIVTACQEGFICTWGRPGK 502 EDCI+TACQEG ICTW RPGK Sbjct: 613 EDCIITACQEGLICTWARPGK 633 >gi|13376840 WD repeat domain 61 [Homo sapiens] Length = 305 Score = 58.5 bits (140), Expect = 1e-08 Identities = 29/91 (31%), Positives = 50/91 (54%) Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225 A+SPDGK+LA + DG + +F+ + +L T++ + + + +SPD + +VT +D + Sbjct: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214 Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTT 256 ++ + GH SWV VAF P T Sbjct: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245 Score = 50.4 bits (119), Expect = 4e-06 Identities = 26/103 (25%), Positives = 52/103 (50%), Gaps = 8/103 (7%) Query: 151 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS 210 P+ WT+ AFSPD ++LA + G + +F +S + ++ + +L + +S Sbjct: 106 PVDAWTL--------AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYS 157 Query: 211 PDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253 PDGKY+ +G D ++ ++ +++ GH + + F P Sbjct: 158 PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200 Score = 48.9 bits (115), Expect = 1e-05 Identities = 20/67 (29%), Positives = 34/67 (50%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221 + FSPD + L S DG++++++ L GT+ + +L V + PD + V+ Sbjct: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252 Query: 222 DDLVTVW 228 D V VW Sbjct: 253 DKSVKVW 259 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 56.2 bits (134), Expect = 7e-08 Identities = 29/100 (29%), Positives = 54/100 (54%), Gaps = 1/100 (1%) Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220 A+ AFSP GK+LA S D +R ++ + H T K + +L + WSPDG+ + +G Sbjct: 116 AVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGC 175 Query: 221 EDDLVTVWSFVDCRVIARG-HGHKSWVSVVAFDPYTTSVE 259 ++ + +W + + R GH W++ ++++P + E Sbjct: 176 KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215 Score = 55.5 bits (132), Expect = 1e-07 Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 21/181 (11%) Query: 168 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 227 +P+ +++A S+DG +R+++ + + + + C+ W DG + + +D + V Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV 271 Query: 228 WSFVD---CRVIARGHGHKSWVSVVAFD-PYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR 283 W D CR + +GHGH WV+ +A Y +P E S + +D Q L ++R Sbjct: 272 WRAHDGVLCRTL-QGHGH--WVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328 Query: 284 ANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVM 343 A LS+ N + R S D L LW ED +PL+R H ++ Sbjct: 329 A------LSRYNLVRGQGPE---RLVSGSDDFTLFLWSPAED----KKPLTRMTGHQALI 375 Query: 344 N 344 N Sbjct: 376 N 376 Score = 53.1 bits (126), Expect = 6e-07 Identities = 28/132 (21%), Positives = 59/132 (44%) Query: 130 QLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD 189 +L+ + F + + PL + T + +N+ FSPD + +A S D +++++ Sbjct: 343 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 402 Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249 + + +++ + + + WS D + +V+G D + VW ++ GH V V Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 462 Query: 250 AFDPYTTSVEEG 261 + P V G Sbjct: 463 DWSPDGQRVASG 474 Score = 44.7 bits (104), Expect = 2e-04 Identities = 20/68 (29%), Positives = 38/68 (55%) Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220 A+ + A+S D + L S D L+V++ + +L + + + V WSPDG+ + +GG Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 475 Query: 221 EDDLVTVW 228 +D + +W Sbjct: 476 KDKCLRIW 483 Score = 35.0 bits (79), Expect = 0.16 Identities = 15/58 (25%), Positives = 28/58 (48%) Query: 196 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253 +++ + ++ V +SP GKY+ +G D V W GH+ WV +++ P Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166 >gi|26665869 WD repeat domain 51B [Homo sapiens] Length = 478 Score = 54.7 bits (130), Expect = 2e-07 Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 14/187 (7%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 FSP G LA S+D +R++ D K++ + V +S DG+++ T ED + Sbjct: 68 FSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127 Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANS 286 VWS R + + H WV F P +G + D+ + + N+ Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSP------DGRLIVSCSEDKTIKIWDTTNKQCVNN 181 Query: 287 TQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNAT 346 + N D P S G D + +WD+ + L H + H+ +N Sbjct: 182 FSDSVGFANFVDFNPSGTC--IASAGSDQTVKVWDVRVNKLLQHY-----QVHSGGVNCI 234 Query: 347 S-PPAGS 352 S P+G+ Sbjct: 235 SFHPSGN 241 Score = 46.2 bits (108), Expect = 7e-05 Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 11/145 (7%) Query: 160 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 219 G N F+P G +A D ++V++ +L + + GG+ C+ + P G Y++T Sbjct: 187 GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITA 246 Query: 220 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLL-- 277 D + + ++ R+I GH V +T S +G + F+ D Q LL Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGPV-------FTVSFSKGGEL-FASGGADTQVLLWR 298 Query: 278 -HFGRDRANSTQSRLSKRNSTDSRP 301 +F R KR DS P Sbjct: 299 TNFDELHCKGLTKRNLKRLHFDSPP 323 Score = 45.8 bits (107), Expect = 9e-05 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Query: 150 NPLLK-WTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC 208 N LL+ + V G +N +F P G +L S DG L++ + L T++ + G + V Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277 Query: 209 WSPDGKYIVTGGEDDLVTVW 228 +S G+ +GG D V +W Sbjct: 278 FSKGGELFASGGADTQVLLW 297 Score = 44.7 bits (104), Expect = 2e-04 Identities = 40/167 (23%), Positives = 70/167 (41%), Gaps = 20/167 (11%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 FSPDG+ + S+D +++++ + + G V ++P G I + G D V Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 211 Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANS 286 VW +++ H V+ ++F P G+ + + SD + L + Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHP------SGNYLITASSDGTLKIL--------DL 257 Query: 287 TQSRLSKRNSTDSRPV-SVTYR-----FGSVGQDTQLCLWDLTEDIL 327 + RL + PV +V++ F S G DTQ+ LW D L Sbjct: 258 LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304 Score = 32.7 bits (73), Expect = 0.80 Identities = 16/45 (35%), Positives = 23/45 (51%) Query: 210 SPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPY 254 SP+GK + T D + +W+F R GHK V+ V F P+ Sbjct: 27 SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71 >gi|62234438 Notchless gene homolog isoform b [Homo sapiens] Length = 193 Score = 53.1 bits (126), Expect = 6e-07 Identities = 28/132 (21%), Positives = 59/132 (44%) Query: 130 QLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD 189 +L+ + F + + PL + T + +N+ FSPD + +A S D +++++ Sbjct: 51 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 110 Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249 + + +++ + + + WS D + +V+G D + VW ++ GH V V Sbjct: 111 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 170 Query: 250 AFDPYTTSVEEG 261 + P V G Sbjct: 171 DWSPDGQRVASG 182 Score = 44.7 bits (104), Expect = 2e-04 Identities = 20/68 (29%), Positives = 38/68 (55%) Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220 A+ + A+S D + L S D L+V++ + +L + + + V WSPDG+ + +GG Sbjct: 124 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 183 Query: 221 EDDLVTVW 228 +D + +W Sbjct: 184 KDKCLRIW 191 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 52.8 bits (125), Expect = 7e-07 Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 6/109 (5%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221 +N A +P+ K LA SQD +++ +L G + GL CV +SP + + T Sbjct: 482 INSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASA 541 Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSD 270 D + +W+ D + GH + V VAF V G + SGSD Sbjct: 542 DGTIKLWALQDFSCLKTFEGHDASVLKVAF------VSRGTQLLSSGSD 584 Score = 35.8 bits (81), Expect = 0.095 Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 FSP + LA S DG ++++ T + + +L V + G +++ G D LV Sbjct: 529 FSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVK 588 Query: 227 VWSFV--DCRVIARGHGHKSW 245 +W+ +C H K W Sbjct: 589 LWTIKNNECVRTLDAHEDKVW 609 Score = 34.7 bits (78), Expect = 0.21 Identities = 17/77 (22%), Positives = 35/77 (45%), Gaps = 2/77 (2%) Query: 160 GALNEFAFSPDGKFLACVSQ--DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIV 217 G ++ AF PD L S D +RV++ + +++ + + +S DG ++ Sbjct: 152 GVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTML 211 Query: 218 TGGEDDLVTVWSFVDCR 234 + G D + +W C+ Sbjct: 212 SSGRDKICIIWDLQSCQ 228 Score = 32.3 bits (72), Expect = 1.0 Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 12/110 (10%) Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGT--MKSYFGGLLCVCWSPDGKYIV--TGGE 221 AF P LA DG +RV+ D V +GT + G + V + PD ++ + Sbjct: 116 AFDPTSTLLATGGCDGAVRVW--DIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173 Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271 D + VWS D +A H S V+ +AF +G M SG D+ Sbjct: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFS------ADGHTMLSSGRDK 217 Score = 29.6 bits (65), Expect = 6.8 Identities = 24/96 (25%), Positives = 37/96 (38%), Gaps = 1/96 (1%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKS-YFGGLLCVCWSPDGKYIVTGG 220 + F SPD + L S+ L + + + K+ + + + + P + TGG Sbjct: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGG 128 Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTT 256 D V VW V G V +VAF P T Sbjct: 129 CDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164 >gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo sapiens] Length = 513 Score = 52.0 bits (123), Expect = 1e-06 Identities = 28/101 (27%), Positives = 51/101 (50%), Gaps = 9/101 (8%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMK--------SYFGGLLCVCWSPDGKYIVT 218 FSPDG++L S DGF+ V+NF + ++ +K +LC+C+S D + + T Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281 Query: 219 GGEDDLVTVWSFVDCRVIAR-GHGHKSWVSVVAFDPYTTSV 258 G +D + VW + + R H V+ ++F ++ + Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI 322 Score = 36.6 bits (83), Expect = 0.055 Identities = 13/30 (43%), Positives = 20/30 (66%) Query: 206 CVCWSPDGKYIVTGGEDDLVTVWSFVDCRV 235 C +SPDG+Y+VTG D + VW+F ++ Sbjct: 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKI 248 Score = 34.7 bits (78), Expect = 0.21 Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 3/64 (4%) Query: 136 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 195 ++ +H KS T L ++ +NE F+ DG ++ S DG ++++N + E Sbjct: 329 QTIRIHGLKSGKT---LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385 Query: 196 TMKS 199 T KS Sbjct: 386 TFKS 389 Score = 34.3 bits (77), Expect = 0.28 Identities = 18/63 (28%), Positives = 32/63 (50%) Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225 A SP G+++ CV +D L F+ + +L T+ + ++ + P I T ED L+ Sbjct: 449 ALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLL 508 Query: 226 TVW 228 +W Sbjct: 509 KLW 511 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 51.2 bits (121), Expect = 2e-06 Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 2/114 (1%) Query: 150 NPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207 N LK+T+ A++ FSP+G++LA S D ++++ + T+ + G+ V Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 Query: 208 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261 WS D +V+ +D + +W + + GH ++V F+P + + G Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 Score = 45.1 bits (105), Expect = 2e-04 Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 3/90 (3%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS---PDGKYIVTGGEDD 223 FSP+GK++ + D L+++++ + T + C+ + GK+IV+G ED+ Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281 Query: 224 LVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253 LV +W+ ++ + GH V A P Sbjct: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 Score = 43.1 bits (100), Expect = 6e-04 Identities = 23/91 (25%), Positives = 43/91 (47%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221 +++ A+S D L S D L++++ S + T+K + + C ++P IV+G Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 252 D+ V +W + + H VS V F+ Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180 Score = 34.3 bits (77), Expect = 0.28 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLC-VCWSPDGKYIVTGGEDDLV 225 F+ DG + S DG R+++ S + T+ + V +SP+GKYI+ D+ + Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 Query: 226 TVWSFVDCRVIARGHGHKS 244 +W + + + GHK+ Sbjct: 239 KLWDYSKGKCLKTYTGHKN 257 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 51.2 bits (121), Expect = 2e-06 Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 2/114 (1%) Query: 150 NPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207 N LK+T+ A++ FSP+G++LA S D ++++ + T+ + G+ V Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 Query: 208 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261 WS D +V+ +D + +W + + GH ++V F+P + + G Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 Score = 45.1 bits (105), Expect = 2e-04 Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 3/90 (3%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS---PDGKYIVTGGEDD 223 FSP+GK++ + D L+++++ + T + C+ + GK+IV+G ED+ Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281 Query: 224 LVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253 LV +W+ ++ + GH V A P Sbjct: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 Score = 43.1 bits (100), Expect = 6e-04 Identities = 23/91 (25%), Positives = 43/91 (47%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221 +++ A+S D L S D L++++ S + T+K + + C ++P IV+G Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 252 D+ V +W + + H VS V F+ Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180 Score = 34.3 bits (77), Expect = 0.28 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLC-VCWSPDGKYIVTGGEDDLV 225 F+ DG + S DG R+++ S + T+ + V +SP+GKYI+ D+ + Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 Query: 226 TVWSFVDCRVIARGHGHKS 244 +W + + + GHK+ Sbjct: 239 KLWDYSKGKCLKTYTGHKN 257 >gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo sapiens] Length = 1205 Score = 51.2 bits (121), Expect = 2e-06 Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 20/146 (13%) Query: 124 TTAPHYQLLKQGES---FAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180 T + H+ LL G S + K RN + T ++N FSPD K LA S D Sbjct: 708 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT---NSVNHCRFSPDDKLLASCSAD 764 Query: 181 GFLRVFNFDSVELHGT--MKSYFGGL-----------LCVCWSPDGKYIVTGGEDDLVTV 227 G L++++ S + +K +F L C WS DG I+ ++ + + Sbjct: 765 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFL 823 Query: 228 WSFVDCRVIARGHGHKSWVSVVAFDP 253 W+ +A GH SWV V F P Sbjct: 824 WNTDSRSKVADCRGHLSWVHGVMFSP 849 Score = 40.8 bits (94), Expect = 0.003 Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 8/164 (4%) Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220 A+ FS DG+ +A D L+VF ++ E +K++ +LC +S D ++I T Sbjct: 617 AVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCS 676 Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 280 D V +W+ + ++ H V+ F + + + +GS + F L Sbjct: 677 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-----LLATGSSDCFLKLWDLN 731 Query: 281 RDRANSTQSRLSKRNSTDSRPVSVTYR-FGSVGQDTQLCLWDLT 323 + +T NS + S + S D L LWD T Sbjct: 732 QKECRNTM--FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773 Score = 33.9 bits (76), Expect = 0.36 Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 8/78 (10%) Query: 151 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVEL--------HGTMKSYFG 202 PL + G + AFS D LA +G +R++N + EL ++ G Sbjct: 1076 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1135 Query: 203 GLLCVCWSPDGKYIVTGG 220 + +C+SPDGK +++ G Sbjct: 1136 WVTDLCFSPDGKMLISAG 1153 Score = 31.2 bits (69), Expect = 2.3 Identities = 20/103 (19%), Positives = 44/103 (42%), Gaps = 8/103 (7%) Query: 159 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVT 218 +G + S D + S D ++++FD + ++ + G + C +S D + T Sbjct: 1042 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1101 Query: 219 GGEDDLVTVWSFVD------CRVIAR--GHGHKSWVSVVAFDP 253 G ++ + +W+ + C ++ H WV+ + F P Sbjct: 1102 GDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1144 >gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo sapiens] Length = 1194 Score = 51.2 bits (121), Expect = 2e-06 Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 20/146 (13%) Query: 124 TTAPHYQLLKQGES---FAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180 T + H+ LL G S + K RN + T ++N FSPD K LA S D Sbjct: 697 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT---NSVNHCRFSPDDKLLASCSAD 753 Query: 181 GFLRVFNFDSVELHGT--MKSYFGGL-----------LCVCWSPDGKYIVTGGEDDLVTV 227 G L++++ S + +K +F L C WS DG I+ ++ + + Sbjct: 754 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFL 812 Query: 228 WSFVDCRVIARGHGHKSWVSVVAFDP 253 W+ +A GH SWV V F P Sbjct: 813 WNTDSRSKVADCRGHLSWVHGVMFSP 838 Score = 40.8 bits (94), Expect = 0.003 Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 8/164 (4%) Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220 A+ FS DG+ +A D L+VF ++ E +K++ +LC +S D ++I T Sbjct: 606 AVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCS 665 Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 280 D V +W+ + ++ H V+ F + + + +GS + F L Sbjct: 666 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-----LLATGSSDCFLKLWDLN 720 Query: 281 RDRANSTQSRLSKRNSTDSRPVSVTYR-FGSVGQDTQLCLWDLT 323 + +T NS + S + S D L LWD T Sbjct: 721 QKECRNTM--FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762 Score = 33.9 bits (76), Expect = 0.36 Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 8/78 (10%) Query: 151 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVEL--------HGTMKSYFG 202 PL + G + AFS D LA +G +R++N + EL ++ G Sbjct: 1065 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1124 Query: 203 GLLCVCWSPDGKYIVTGG 220 + +C+SPDGK +++ G Sbjct: 1125 WVTDLCFSPDGKMLISAG 1142 Score = 31.2 bits (69), Expect = 2.3 Identities = 20/103 (19%), Positives = 44/103 (42%), Gaps = 8/103 (7%) Query: 159 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVT 218 +G + S D + S D ++++FD + ++ + G + C +S D + T Sbjct: 1031 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1090 Query: 219 GGEDDLVTVWSFVD------CRVIAR--GHGHKSWVSVVAFDP 253 G ++ + +W+ + C ++ H WV+ + F P Sbjct: 1091 GDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1133 >gi|5174447 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [Homo sapiens] Length = 317 Score = 50.8 bits (120), Expect = 3e-06 Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 9/165 (5%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221 +++ S DG+F S DG LR+++ + + +L V +S D + IV+G Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 Query: 222 DDLVTVWSFVD-CRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 280 D + +W+ + C+ + H WVS V F P +P+ S + + + Sbjct: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP-----NSSNPIIVSCGWDKLVKVWNLA 180 Query: 281 RDRANSTQ-SRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 324 + + N+ P G G+D Q LWDL E Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASG--GKDGQAMLWDLNE 223 Score = 32.3 bits (72), Expect = 1.0 Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 6/81 (7%) Query: 154 KWTVGEGALNEFA----FSPDGKFLACVS--QDGFLRVFNFDSVELHGTMKSYFGGLLCV 207 K+TV + + +E+ FSP+ VS D ++V+N + +L + G L V Sbjct: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198 Query: 208 CWSPDGKYIVTGGEDDLVTVW 228 SPDG +GG+D +W Sbjct: 199 TVSPDGSLCASGGKDGQAMLW 219 >gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] Length = 466 Score = 49.3 bits (116), Expect = 8e-06 Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 1/75 (1%) Query: 159 EGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVELHGTMKSYFGGLLCVCWSPDGKYIV 217 +G + + A+S DG FLA + VF+ D + + ++C+ WSPD ++ Sbjct: 349 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 408 Query: 218 TGGEDDLVTVWSFVD 232 +GG D +V VW+ D Sbjct: 409 SGGMDMMVYVWTLSD 423 Score = 42.7 bits (99), Expect = 8e-04 Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 3/70 (4%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVE---LHGTMKSYFGGLLCVCWSPDGKYIVT 218 +N FSPDG A S DG + +++ + E G K++ GG+ + WSPD ++++ Sbjct: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111 Query: 219 GGEDDLVTVW 228 D +W Sbjct: 112 ASGDKTSKIW 121 >gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] Length = 606 Score = 49.3 bits (116), Expect = 8e-06 Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 1/75 (1%) Query: 159 EGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVELHGTMKSYFGGLLCVCWSPDGKYIV 217 +G + + A+S DG FLA + VF+ D + + ++C+ WSPD ++ Sbjct: 489 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 548 Query: 218 TGGEDDLVTVWSFVD 232 +GG D +V VW+ D Sbjct: 549 SGGMDMMVYVWTLSD 563 Score = 47.8 bits (112), Expect = 2e-05 Identities = 36/158 (22%), Positives = 72/158 (45%), Gaps = 19/158 (12%) Query: 90 RVTCVKWVPGSESLFLVAHSS---GNMYLYNVEHTCGTTAPHYQLL-----KQGESFAVH 141 ++ + W S+ + +V G ++L++ + G H +++ KQ + + Sbjct: 104 KIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLA 163 Query: 142 T-----CKSKSTRNPL-LKWTVGEGA--LNEFAFSPDGKFLACVSQDGFLRVFNFDSVE- 192 T C + P K+T+G+ + +N FSPDG A S DG + +++ + E Sbjct: 164 TGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK 223 Query: 193 --LHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVW 228 G K++ GG+ + WSPD ++++ D +W Sbjct: 224 VCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261 >gi|148727341 serine/threonine kinase receptor associated protein [Homo sapiens] Length = 350 Score = 48.5 bits (114), Expect = 1e-05 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 4/101 (3%) Query: 131 LLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDS 190 ++ G S A H+ S +K +N + P+ +FL +D L ++++S Sbjct: 199 VITYGRSIAFHSAVSLDP----IKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNS 254 Query: 191 VELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFV 231 E + K +FG + CV +SPDG+ +G ED + +W V Sbjct: 255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTV 295 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 48.1 bits (113), Expect = 2e-05 Identities = 24/87 (27%), Positives = 46/87 (52%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 F P G+F+A SQD +++++ + + + C+ +SPDGK++ + +D V Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172 Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253 +W ++++ GH V+VV F P Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHP 199 Score = 39.7 bits (91), Expect = 0.007 Identities = 21/87 (24%), Positives = 42/87 (48%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 FSPDGK+LA + D +++++ + ++ + G + V + P+ + +G D + Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214 Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253 W +V++ G V V F+P Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNP 241 Score = 39.3 bits (90), Expect = 0.009 Identities = 17/76 (22%), Positives = 38/76 (50%) Query: 178 SQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIA 237 SQ G +RV++ ++ ++ T+ + + + + P G+++ +G +D + +W + Sbjct: 82 SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF 141 Query: 238 RGHGHKSWVSVVAFDP 253 R GH V + F P Sbjct: 142 RYRGHSQAVRCLRFSP 157 Score = 30.0 bits (66), Expect = 5.2 Identities = 34/156 (21%), Positives = 63/156 (40%), Gaps = 14/156 (8%) Query: 171 GKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSF 230 G+ LA D + +++ + ++ + + V + + IV G + + VW Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92 Query: 231 VDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG---RDRANST 287 +++ GHK+ + + F PY V G ++ D+ G R R +S Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGS----QDTNIKLWDIRRKGCVFRYRGHS- 147 Query: 288 QSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLT 323 Q+ R S D + ++ S D + LWDLT Sbjct: 148 QAVRCLRFSPDGKWLA------SAADDHTVKLWDLT 177 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 48.1 bits (113), Expect = 2e-05 Identities = 29/102 (28%), Positives = 47/102 (46%) Query: 160 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 219 G +N AFSPDG+ L S+DG + + S +L + + G + +SPDG + Sbjct: 22 GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA 81 Query: 220 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261 D V +W + + GH+ V V+F P + + G Sbjct: 82 SCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123 Score = 47.4 bits (111), Expect = 3e-05 Identities = 30/116 (25%), Positives = 52/116 (44%), Gaps = 2/116 (1%) Query: 148 TRNPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLL 205 TR+ L W +G G + FSPDG A S D +R+++ + +K + + Sbjct: 50 TRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVE 109 Query: 206 CVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261 V +SPD + + +GG D V +W +++ GH+ + F P + G Sbjct: 110 TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATG 165 Score = 43.1 bits (100), Expect = 6e-04 Identities = 26/106 (24%), Positives = 49/106 (46%), Gaps = 5/106 (4%) Query: 152 LLKWTVGE-GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVE---LHGTMKSYFGGLLCV 207 +L+ VG ++ FSP LA S D + +++ V H ++ + + C+ Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198 Query: 208 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253 C+S G + +G D + +W ++ + GH +WV +AF P Sbjct: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243 Score = 33.1 bits (74), Expect = 0.61 Identities = 17/61 (27%), Positives = 31/61 (50%) Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221 + AFSPD +LA ++V++ ++ + T+K ++PDGK +V+G Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295 Query: 222 D 222 D Sbjct: 296 D 296 >gi|189571685 WD repeat, sterile alpha motif and U-box domain containing 1 [Homo sapiens] Length = 476 Score = 48.1 bits (113), Expect = 2e-05 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 225 FSP G LA S DG ++N ++ ++ M+ G + VC +SPD + +G D V Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121 Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 284 +W+ ++ G ++ AF P + G +D LH + Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181 Query: 285 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 320 T S + +D +R S GQD Q+ +W Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217 Score = 42.0 bits (97), Expect = 0.001 Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%) Query: 124 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 162 T PH L + ++AVH C S ST + W G + Sbjct: 43 TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100 Query: 163 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222 FSPD LA + DG + ++N S +L+ G L +SP+G + VTG Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160 Query: 223 DLVTVW 228 +TVW Sbjct: 161 GDLTVW 166 Score = 34.3 bits (77), Expect = 0.28 Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%) Query: 165 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 222 F+FS LA S D +R+++ D EL H +K + + C C+SP G + + D Sbjct: 20 FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75 Query: 223 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 261 +W+ + +++A S V V F P +T + G Sbjct: 76 GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115 Score = 32.7 bits (73), Expect = 0.80 Identities = 17/65 (26%), Positives = 32/65 (49%) Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225 AFS DG+ L S D + V++ ++ + T+ + + ++P+ + TG D V Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305 Query: 226 TVWSF 230 +W F Sbjct: 306 NIWQF 310 Score = 30.0 bits (66), Expect = 5.2 Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%) Query: 156 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 211 +V +G+L AFSP+G F S G L V++ D + + K++ G+ C +S Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194 Query: 212 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 265 DG+ + + G+D V +W ++ +KS +S + M Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254 Query: 266 FSGS--------DEDFQDLLH 278 SGS D + +++LH Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275 >gi|189571683 WD repeat, sterile alpha motif and U-box domain containing 1 [Homo sapiens] Length = 476 Score = 48.1 bits (113), Expect = 2e-05 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 225 FSP G LA S DG ++N ++ ++ M+ G + VC +SPD + +G D V Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121 Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 284 +W+ ++ G ++ AF P + G +D LH + Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181 Query: 285 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 320 T S + +D +R S GQD Q+ +W Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217 Score = 42.0 bits (97), Expect = 0.001 Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%) Query: 124 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 162 T PH L + ++AVH C S ST + W G + Sbjct: 43 TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100 Query: 163 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222 FSPD LA + DG + ++N S +L+ G L +SP+G + VTG Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160 Query: 223 DLVTVW 228 +TVW Sbjct: 161 GDLTVW 166 Score = 34.3 bits (77), Expect = 0.28 Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%) Query: 165 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 222 F+FS LA S D +R+++ D EL H +K + + C C+SP G + + D Sbjct: 20 FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75 Query: 223 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 261 +W+ + +++A S V V F P +T + G Sbjct: 76 GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115 Score = 32.7 bits (73), Expect = 0.80 Identities = 17/65 (26%), Positives = 32/65 (49%) Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225 AFS DG+ L S D + V++ ++ + T+ + + ++P+ + TG D V Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305 Query: 226 TVWSF 230 +W F Sbjct: 306 NIWQF 310 Score = 30.0 bits (66), Expect = 5.2 Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%) Query: 156 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 211 +V +G+L AFSP+G F S G L V++ D + + K++ G+ C +S Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194 Query: 212 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 265 DG+ + + G+D V +W ++ +KS +S + M Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254 Query: 266 FSGS--------DEDFQDLLH 278 SGS D + +++LH Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275 >gi|189571681 WD repeat, sterile alpha motif and U-box domain containing 1 [Homo sapiens] Length = 476 Score = 48.1 bits (113), Expect = 2e-05 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 225 FSP G LA S DG ++N ++ ++ M+ G + VC +SPD + +G D V Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121 Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 284 +W+ ++ G ++ AF P + G +D LH + Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181 Query: 285 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 320 T S + +D +R S GQD Q+ +W Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217 Score = 42.0 bits (97), Expect = 0.001 Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%) Query: 124 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 162 T PH L + ++AVH C S ST + W G + Sbjct: 43 TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100 Query: 163 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222 FSPD LA + DG + ++N S +L+ G L +SP+G + VTG Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160 Query: 223 DLVTVW 228 +TVW Sbjct: 161 GDLTVW 166 Score = 34.3 bits (77), Expect = 0.28 Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%) Query: 165 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 222 F+FS LA S D +R+++ D EL H +K + + C C+SP G + + D Sbjct: 20 FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75 Query: 223 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 261 +W+ + +++A S V V F P +T + G Sbjct: 76 GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115 Score = 32.7 bits (73), Expect = 0.80 Identities = 17/65 (26%), Positives = 32/65 (49%) Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225 AFS DG+ L S D + V++ ++ + T+ + + ++P+ + TG D V Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305 Query: 226 TVWSF 230 +W F Sbjct: 306 NIWQF 310 Score = 30.0 bits (66), Expect = 5.2 Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%) Query: 156 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 211 +V +G+L AFSP+G F S G L V++ D + + K++ G+ C +S Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194 Query: 212 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 265 DG+ + + G+D V +W ++ +KS +S + M Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254 Query: 266 FSGS--------DEDFQDLLH 278 SGS D + +++LH Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 47.4 bits (111), Expect = 3e-05 Identities = 31/123 (25%), Positives = 53/123 (43%) Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181 C P+ L G + S N + +T G + AFSP+GK+LA +D Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490 Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241 L++++ S L+ ++ + + + +SPD I + D+ V VW + A G Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADG 550 Query: 242 HKS 244 S Sbjct: 551 SSS 553 Score = 45.1 bits (105), Expect = 2e-04 Identities = 22/87 (25%), Positives = 41/87 (47%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 F P+ +LA S D +R+++ + G +L + +SP+GKY+ + GED + Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLK 493 Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253 +W + GH ++ + F P Sbjct: 494 LWDLASGTLYKELRGHTDNITSLTFSP 520 Score = 40.8 bits (94), Expect = 0.003 Identities = 24/86 (27%), Positives = 37/86 (43%) Query: 168 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 227 SP + A S D R+++FD + + CV + P+ Y+ TG D V + Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452 Query: 228 WSFVDCRVIARGHGHKSWVSVVAFDP 253 WS + GH+ V +AF P Sbjct: 453 WSAQQGNSVRLFTGHRGPVLSLAFSP 478 Score = 36.6 bits (83), Expect = 0.055 Identities = 49/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%) Query: 160 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCW----SPDGKY 215 G + F D L S+D +R ++ S T + G W SP Y Sbjct: 343 GPVYSTRFLADSSGLLSCSEDMSIRYWDLGSF----TNTVLYQGHAYPVWDLDISPYSLY 398 Query: 216 IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQD 275 +G D +WSF + GH + V V F P + + G +D+ + Sbjct: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGS------TDKTVR- 451 Query: 276 LLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRF-GSVGQDTQLCLWDLTEDILFPHQPLS 334 + + NS + R S S ++ S G+D +L LWDL L+ Sbjct: 452 --LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY-----K 504 Query: 335 RARTHT-NVMNAT-SPPAG 351 R HT N+ + T SP +G Sbjct: 505 ELRGHTDNITSLTFSPDSG 523 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 46.6 bits (109), Expect = 5e-05 Identities = 24/81 (29%), Positives = 38/81 (46%) Query: 148 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207 T L + + A+N +F P G +L S D L++ + L T+ + G V Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239 Query: 208 CWSPDGKYIVTGGEDDLVTVW 228 +S G+Y +GG D+ V VW Sbjct: 240 AFSRTGEYFASGGSDEQVMVW 260 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%) Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181 C +P +L+ KS+R + + G + F P G +A D Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171 Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241 ++V++ + L + + + + + P G Y++T D + + ++ R++ HG Sbjct: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 231 Query: 242 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271 H+ + VAF G+ GSDE Sbjct: 232 HQGPATTVAFS------RTGEYFASGGSDE 255 Score = 39.7 bits (91), Expect = 0.007 Identities = 28/138 (20%), Positives = 51/138 (36%) Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180 TC +P LL G + + + + F DG+ S D Sbjct: 27 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 86 Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240 ++V+ + ++ + + C +SPDG+ IV+ +D V +W + Sbjct: 87 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 146 Query: 241 GHKSWVSVVAFDPYTTSV 258 H +V+ V F P T + Sbjct: 147 EHGGFVTYVDFHPSGTCI 164 Score = 37.7 bits (86), Expect = 0.025 Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%) Query: 154 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 213 ++T + A+ FSP G LA S+D +R++ + +++ + V + DG Sbjct: 18 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 77 Query: 214 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 273 + VT +D V VW+ + + H +WV F P +G + + D+ Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 131 Query: 274 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 333 + R+ +S D P + G D + +WD+ L H L Sbjct: 132 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 189 Query: 334 SRA 336 A Sbjct: 190 HSA 192 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 46.6 bits (109), Expect = 5e-05 Identities = 24/81 (29%), Positives = 38/81 (46%) Query: 148 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207 T L + + A+N +F P G +L S D L++ + L T+ + G V Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277 Query: 208 CWSPDGKYIVTGGEDDLVTVW 228 +S G+Y +GG D+ V VW Sbjct: 278 AFSRTGEYFASGGSDEQVMVW 298 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%) Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181 C +P +L+ KS+R + + G + F P G +A D Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 209 Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241 ++V++ + L + + + + + P G Y++T D + + ++ R++ HG Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 269 Query: 242 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271 H+ + VAF G+ GSDE Sbjct: 270 HQGPATTVAFS------RTGEYFASGGSDE 293 Score = 39.7 bits (91), Expect = 0.007 Identities = 28/138 (20%), Positives = 51/138 (36%) Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180 TC +P LL G + + + + F DG+ S D Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124 Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240 ++V+ + ++ + + C +SPDG+ IV+ +D V +W + Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184 Query: 241 GHKSWVSVVAFDPYTTSV 258 H +V+ V F P T + Sbjct: 185 EHGGFVTYVDFHPSGTCI 202 Score = 37.7 bits (86), Expect = 0.025 Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%) Query: 154 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 213 ++T + A+ FSP G LA S+D +R++ + +++ + V + DG Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115 Query: 214 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 273 + VT +D V VW+ + + H +WV F P +G + + D+ Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 169 Query: 274 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 333 + R+ +S D P + G D + +WD+ L H L Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 227 Query: 334 SRA 336 A Sbjct: 228 HSA 230 Score = 31.6 bits (70), Expect = 1.8 Identities = 18/62 (29%), Positives = 27/62 (43%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 FS + K LA S D L V++ + + CV +SP G + +G D V Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 86 Query: 227 VW 228 +W Sbjct: 87 IW 88 Score = 31.2 bits (69), Expect = 2.3 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%) Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249 S+E H K + + CV +S + K + +G D + VW R GHK V+ V Sbjct: 10 SLERH--FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67 Query: 250 AFDP 253 F P Sbjct: 68 NFSP 71 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 46.6 bits (109), Expect = 5e-05 Identities = 24/81 (29%), Positives = 38/81 (46%) Query: 148 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207 T L + + A+N +F P G +L S D L++ + L T+ + G V Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277 Query: 208 CWSPDGKYIVTGGEDDLVTVW 228 +S G+Y +GG D+ V VW Sbjct: 278 AFSRTGEYFASGGSDEQVMVW 298 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%) Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181 C +P +L+ KS+R + + G + F P G +A D Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 209 Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241 ++V++ + L + + + + + P G Y++T D + + ++ R++ HG Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 269 Query: 242 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271 H+ + VAF G+ GSDE Sbjct: 270 HQGPATTVAFS------RTGEYFASGGSDE 293 Score = 39.7 bits (91), Expect = 0.007 Identities = 28/138 (20%), Positives = 51/138 (36%) Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180 TC +P LL G + + + + F DG+ S D Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124 Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240 ++V+ + ++ + + C +SPDG+ IV+ +D V +W + Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184 Query: 241 GHKSWVSVVAFDPYTTSV 258 H +V+ V F P T + Sbjct: 185 EHGGFVTYVDFHPSGTCI 202 Score = 37.7 bits (86), Expect = 0.025 Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%) Query: 154 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 213 ++T + A+ FSP G LA S+D +R++ + +++ + V + DG Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115 Query: 214 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 273 + VT +D V VW+ + + H +WV F P +G + + D+ Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 169 Query: 274 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 333 + R+ +S D P + G D + +WD+ L H L Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 227 Query: 334 SRA 336 A Sbjct: 228 HSA 230 Score = 31.6 bits (70), Expect = 1.8 Identities = 18/62 (29%), Positives = 27/62 (43%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 FS + K LA S D L V++ + + CV +SP G + +G D V Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 86 Query: 227 VW 228 +W Sbjct: 87 IW 88 Score = 31.2 bits (69), Expect = 2.3 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%) Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249 S+E H K + + CV +S + K + +G D + VW R GHK V+ V Sbjct: 10 SLERH--FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67 Query: 250 AFDP 253 F P Sbjct: 68 NFSP 71 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 46.2 bits (108), Expect = 7e-05 Identities = 23/89 (25%), Positives = 42/89 (47%) Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220 ++ + +F GK LA S D +++++F E TM + + V P+G +IV+ Sbjct: 152 SVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS 211 Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVV 249 D + +W + GH+ WV +V Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGHREWVRMV 240 Score = 41.2 bits (95), Expect = 0.002 Identities = 21/87 (24%), Positives = 40/87 (45%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 F P + S+D ++V+++++ + T+K + + + + GK + + D + Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175 Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253 +W F I HGH VS VA P Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMP 202 Score = 34.7 bits (78), Expect = 0.21 Identities = 21/102 (20%), Positives = 40/102 (39%), Gaps = 20/102 (19%) Query: 170 DGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPD----------------- 212 DG +A S D +RV+ + E ++ + + C+ W+P+ Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304 Query: 213 ---GKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAF 251 G ++++G D + +W + GH +WV V F Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF 346 Score = 34.3 bits (77), Expect = 0.28 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 3/68 (4%) Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226 F GKF+ + D LRV+++ + T+ ++ + + + Y+VTG D V Sbjct: 346 FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVK 405 Query: 227 VWSFVDCR 234 VW +CR Sbjct: 406 VW---ECR 410 Score = 30.0 bits (66), Expect = 5.2 Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 5/95 (5%) Query: 171 GKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSF 230 G FL S+D +++++ + T+ + + V + GK+I++ +D + VW + Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367 Query: 231 VDCRVIARGHGHKSWVSVVAFD---PY--TTSVEE 260 + R + + H+ +V+ + F PY T SV++ Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 46.2 bits (108), Expect = 7e-05 Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 8/96 (8%) Query: 166 AFSPDGKFLACVSQDGFLRVFN---FDSVE-----LHGTMKSYFGGLLCVCWSPDGKYIV 217 + S +G +L + D +RV++ F E G + ++ LL WSPDG I Sbjct: 242 SLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIA 301 Query: 218 TGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253 G D V VW R++ + GH ++ VAF P Sbjct: 302 AGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337 Score = 44.3 bits (103), Expect = 3e-04 Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 19/190 (10%) Query: 144 KSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFN-FDSVELHGTMKSYFG 202 + S + P++ + EG + F P+G LA D + ++N + + + T+K + G Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110 Query: 203 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD 262 ++ + ++ DG + + D V VW + R GH S+V+ G Sbjct: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN------SCYPARRGP 164 Query: 263 PMEFSGSDEDFQDLLHFGRDRA-----NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQL 317 + +GSD+ L + A N+ Q N T + + S G D + Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQII-------SGGIDNDI 217 Query: 318 CLWDLTEDIL 327 +WDL ++ L Sbjct: 218 KVWDLRQNKL 227 Score = 29.6 bits (65), Expect = 6.8 Identities = 16/57 (28%), Positives = 29/57 (50%) Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222 ++SPDG +A S D F+ V++ S + + + G + V + PD I++ D Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.134 0.414 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,528,487 Number of Sequences: 37866 Number of extensions: 1020741 Number of successful extensions: 4932 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 160 Number of HSP's successfully gapped in prelim test: 115 Number of HSP's that attempted gapping in prelim test: 3905 Number of HSP's gapped (non-prelim): 960 length of query: 508 length of database: 18,247,518 effective HSP length: 107 effective length of query: 401 effective length of database: 14,195,856 effective search space: 5692538256 effective search space used: 5692538256 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.