Guide to the Human Genome
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Search of human proteins with 31317278

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens]
         (508 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens]             1053   0.0  
gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens]             1017   0.0  
gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens]             1007   0.0  
gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens]              883   0.0  
gi|62945417 dystrophia myotonica-containing WD repeat motif prot...   517   e-146
gi|13376840 WD repeat domain 61 [Homo sapiens]                         59   1e-08
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            56   7e-08
gi|26665869 WD repeat domain 51B [Homo sapiens]                        55   2e-07
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            53   6e-07
gi|19913369 transducin beta-like 3 [Homo sapiens]                      53   7e-07
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    52   1e-06
gi|16554629 WD repeat domain 5 [Homo sapiens]                          51   2e-06
gi|16554627 WD repeat domain 5 [Homo sapiens]                          51   2e-06
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    51   2e-06
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    51   2e-06
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    51   3e-06
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]    49   8e-06
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]     49   8e-06
gi|148727341 serine/threonine kinase receptor associated protein...    49   1e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     48   2e-05
gi|113865883 WD repeat domain 38 [Homo sapiens]                        48   2e-05
gi|189571685 WD repeat, sterile alpha motif and U-box domain con...    48   2e-05
gi|189571683 WD repeat, sterile alpha motif and U-box domain con...    48   2e-05
gi|189571681 WD repeat, sterile alpha motif and U-box domain con...    48   2e-05
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     47   3e-05
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             47   5e-05
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             47   5e-05
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             47   5e-05
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    46   7e-05
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    46   7e-05

>gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens]
          Length = 508

 Score = 1053 bits (2724), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
           MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG
Sbjct: 1   MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60

Query: 61  NGDRLCFNVGRELYFYIYKGVRKRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEH 120
           NGDRLCFNVGRELYFYIYKGVRKRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEH
Sbjct: 61  NGDRLCFNVGRELYFYIYKGVRKRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEH 120

Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180
           TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD
Sbjct: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180

Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240
           GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH
Sbjct: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240

Query: 241 GHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR 300
           GHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR
Sbjct: 241 GHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR 300

Query: 301 PVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTP 360
           PVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTP
Sbjct: 301 PVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTP 360

Query: 361 GNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRN 420
           GNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRN
Sbjct: 361 GNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRN 420

Query: 421 HSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIF 480
           HSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIF
Sbjct: 421 HSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIF 480

Query: 481 LEDCIVTACQEGFICTWGRPGKVVSFNP 508
           LEDCIVTACQEGFICTWGRPGKVVSFNP
Sbjct: 481 LEDCIVTACQEGFICTWGRPGKVVSFNP 508


>gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens]
          Length = 569

 Score = 1017 bits (2629), Expect = 0.0
 Identities = 505/569 (88%), Positives = 507/569 (89%), Gaps = 61/569 (10%)

Query: 1   MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
           MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG
Sbjct: 1   MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60

Query: 61  NGDRLCFNVGRELYFYI------------------YKGVR-------------------- 82
           NGDRLCFNVGRELYFYI                  YKG +                    
Sbjct: 61  NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120

Query: 83  -----------------------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 119
                                  +RLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE
Sbjct: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180

Query: 120 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 179
           HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ
Sbjct: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240

Query: 180 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 239
           DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG
Sbjct: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300

Query: 240 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 299
           HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS
Sbjct: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360

Query: 300 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 359
           RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT
Sbjct: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420

Query: 360 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 419
           PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR
Sbjct: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480

Query: 420 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 479
           NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI
Sbjct: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540

Query: 480 FLEDCIVTACQEGFICTWGRPGKVVSFNP 508
           FLEDCIVTACQEGFICTWGRPGKVVSFNP
Sbjct: 541 FLEDCIVTACQEGFICTWGRPGKVVSFNP 569


>gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens]
          Length = 581

 Score = 1007 bits (2604), Expect = 0.0
 Identities = 501/568 (88%), Positives = 504/568 (88%), Gaps = 61/568 (10%)

Query: 1   MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
           MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG
Sbjct: 1   MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60

Query: 61  NGDRLCFNVGRELYFYI------------------YKGVR-------------------- 82
           NGDRLCFNVGRELYFYI                  YKG +                    
Sbjct: 61  NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120

Query: 83  -----------------------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 119
                                  +RLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE
Sbjct: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180

Query: 120 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 179
           HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ
Sbjct: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240

Query: 180 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 239
           DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG
Sbjct: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300

Query: 240 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 299
           HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS
Sbjct: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360

Query: 300 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 359
           RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT
Sbjct: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420

Query: 360 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 419
           PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR
Sbjct: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480

Query: 420 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 479
           NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI
Sbjct: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540

Query: 480 FLEDCIVTACQEGFICTWGRPGKVVSFN 507
           FLEDCIVTACQEGFICTWGRPGKV S +
Sbjct: 541 FLEDCIVTACQEGFICTWGRPGKVGSLS 568


>gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens]
          Length = 445

 Score =  883 bits (2282), Expect = 0.0
 Identities = 425/426 (99%), Positives = 426/426 (100%)

Query: 83  KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHT 142
           +RLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHT
Sbjct: 20  ERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHT 79

Query: 143 CKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG 202
           CKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG
Sbjct: 80  CKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG 139

Query: 203 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD 262
           GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD
Sbjct: 140 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD 199

Query: 263 PMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDL 322
           PMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDL
Sbjct: 200 PMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDL 259

Query: 323 TEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNA 382
           TEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNA
Sbjct: 260 TEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNA 319

Query: 383 GSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKT 442
           GSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKT
Sbjct: 320 GSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKT 379

Query: 443 DPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGK 502
           DPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGK
Sbjct: 380 DPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGK 439

Query: 503 VVSFNP 508
           VVSFNP
Sbjct: 440 VVSFNP 445


>gi|62945417 dystrophia myotonica-containing WD repeat motif protein
           [Homo sapiens]
          Length = 674

 Score =  517 bits (1331), Expect = e-146
 Identities = 296/621 (47%), Positives = 353/621 (56%), Gaps = 138/621 (22%)

Query: 12  EIKTQFTTREGLYKLLPHSEYSR---------------PNRVPFNSQGSNP--------- 47
           EIK+QF TREG YKLLP    +R               P   P  +  S P         
Sbjct: 21  EIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSP 80

Query: 48  -------------VRVSFVNLN--DQSG-------------NGDRLCFNVGRELYFY--- 76
                        VR+S V L   D +G              GDR+CFN+GRELYFY   
Sbjct: 81  PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGC 140

Query: 77  ------------------IYKGVR------------------------------------ 82
                             IYKG +                                    
Sbjct: 141 CRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKD 200

Query: 83  -------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG 135
                  +RLIDK++VT +KW+P SESLFL +H+SG++YLYNV H C +  P Y LLKQG
Sbjct: 201 TSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQG 260

Query: 136 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 195
           E F+V+  KSK+ RNPL KW VGEG LNEFAFSPDG+ LACVSQDG LRVF+FDS+ L G
Sbjct: 261 EGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRG 320

Query: 196 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 255
            MKSYFGGLLCVCWSPDG+Y+VTGGEDDLVTVWSF + RV+ARGHGHKSWV+ VAFDPYT
Sbjct: 321 LMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYT 380

Query: 256 TSVEE-----GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGS 310
           T  EE     G   E SG +E+ +         A  T S      S   +  S+TYRFGS
Sbjct: 381 TRAEEAATAAGADGERSGEEEEEE-------PEAAGTGSAGGAPLSPLPKAGSITYRFGS 433

Query: 311 VGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPR 370
            GQDTQ CLWDLTED+L+PH PL+R RT       T P A S+      PG  +P  L R
Sbjct: 434 AGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-PLPRSLSR 492

Query: 371 SNSLPHSA-VSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHIS-- 427
           SNSLPH A    AG      +      + +FATL+L +R++R  EK+HKR HS+G+IS  
Sbjct: 493 SNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRG 552

Query: 428 ------SKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFL 481
                 S        V +++ DPAK LGT LCPR+ +VPLLEPL+CKKIA ERLTVL+FL
Sbjct: 553 GSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFL 612

Query: 482 EDCIVTACQEGFICTWGRPGK 502
           EDCI+TACQEG ICTW RPGK
Sbjct: 613 EDCIITACQEGLICTWARPGK 633


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 29/91 (31%), Positives = 50/91 (54%)

Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225
           A+SPDGK+LA  + DG + +F+  + +L  T++ +   +  + +SPD + +VT  +D  +
Sbjct: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214

Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTT 256
            ++      +     GH SWV  VAF P  T
Sbjct: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 26/103 (25%), Positives = 52/103 (50%), Gaps = 8/103 (7%)

Query: 151 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS 210
           P+  WT+        AFSPD ++LA  +  G + +F  +S +   ++ +    +L + +S
Sbjct: 106 PVDAWTL--------AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYS 157

Query: 211 PDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253
           PDGKY+ +G  D ++ ++     +++    GH   +  + F P
Sbjct: 158 PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 20/67 (29%), Positives = 34/67 (50%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221
           +    FSPD + L   S DG++++++     L GT+  +   +L V + PD  + V+   
Sbjct: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252

Query: 222 DDLVTVW 228
           D  V VW
Sbjct: 253 DKSVKVW 259


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 29/100 (29%), Positives = 54/100 (54%), Gaps = 1/100 (1%)

Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220
           A+   AFSP GK+LA  S D  +R ++  +   H T K +   +L + WSPDG+ + +G 
Sbjct: 116 AVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGC 175

Query: 221 EDDLVTVWSFVDCRVIARG-HGHKSWVSVVAFDPYTTSVE 259
           ++  + +W     + + R   GH  W++ ++++P   + E
Sbjct: 176 KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 21/181 (11%)

Query: 168 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 227
           +P+ +++A  S+DG +R+++  +      +  +   + C+ W  DG  + +  +D  + V
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV 271

Query: 228 WSFVD---CRVIARGHGHKSWVSVVAFD-PYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR 283
           W   D   CR + +GHGH  WV+ +A    Y       +P E S + +D Q  L   ++R
Sbjct: 272 WRAHDGVLCRTL-QGHGH--WVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328

Query: 284 ANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVM 343
           A      LS+ N    +      R  S   D  L LW   ED     +PL+R   H  ++
Sbjct: 329 A------LSRYNLVRGQGPE---RLVSGSDDFTLFLWSPAED----KKPLTRMTGHQALI 375

Query: 344 N 344
           N
Sbjct: 376 N 376



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 28/132 (21%), Positives = 59/132 (44%)

Query: 130 QLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD 189
           +L+   + F +        + PL + T  +  +N+  FSPD + +A  S D  +++++  
Sbjct: 343 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 402

Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249
           + +   +++ +   +  + WS D + +V+G  D  + VW     ++     GH   V  V
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 462

Query: 250 AFDPYTTSVEEG 261
            + P    V  G
Sbjct: 463 DWSPDGQRVASG 474



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 20/68 (29%), Positives = 38/68 (55%)

Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220
           A+ + A+S D + L   S D  L+V++  + +L   +  +   +  V WSPDG+ + +GG
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 475

Query: 221 EDDLVTVW 228
           +D  + +W
Sbjct: 476 KDKCLRIW 483



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 15/58 (25%), Positives = 28/58 (48%)

Query: 196 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253
           +++ +   ++ V +SP GKY+ +G  D  V  W            GH+ WV  +++ P
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 14/187 (7%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           FSP G  LA  S+D  +R++  D        K++   +  V +S DG+++ T  ED  + 
Sbjct: 68  FSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127

Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANS 286
           VWS    R +   + H  WV    F P      +G  +     D+  +      +   N+
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSP------DGRLIVSCSEDKTIKIWDTTNKQCVNN 181

Query: 287 TQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNAT 346
               +   N  D  P        S G D  + +WD+  + L  H      + H+  +N  
Sbjct: 182 FSDSVGFANFVDFNPSGTC--IASAGSDQTVKVWDVRVNKLLQHY-----QVHSGGVNCI 234

Query: 347 S-PPAGS 352
           S  P+G+
Sbjct: 235 SFHPSGN 241



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 11/145 (7%)

Query: 160 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 219
           G  N   F+P G  +A    D  ++V++    +L    + + GG+ C+ + P G Y++T 
Sbjct: 187 GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITA 246

Query: 220 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLL-- 277
             D  + +   ++ R+I    GH   V       +T S  +G  + F+    D Q LL  
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGPV-------FTVSFSKGGEL-FASGGADTQVLLWR 298

Query: 278 -HFGRDRANSTQSRLSKRNSTDSRP 301
            +F          R  KR   DS P
Sbjct: 299 TNFDELHCKGLTKRNLKRLHFDSPP 323



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 1/80 (1%)

Query: 150 NPLLK-WTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC 208
           N LL+ + V  G +N  +F P G +L   S DG L++ +     L  T++ + G +  V 
Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277

Query: 209 WSPDGKYIVTGGEDDLVTVW 228
           +S  G+   +GG D  V +W
Sbjct: 278 FSKGGELFASGGADTQVLLW 297



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 40/167 (23%), Positives = 70/167 (41%), Gaps = 20/167 (11%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           FSPDG+ +   S+D  +++++  + +         G    V ++P G  I + G D  V 
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 211

Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANS 286
           VW     +++     H   V+ ++F P       G+ +  + SD   + L        + 
Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHP------SGNYLITASSDGTLKIL--------DL 257

Query: 287 TQSRLSKRNSTDSRPV-SVTYR-----FGSVGQDTQLCLWDLTEDIL 327
            + RL       + PV +V++      F S G DTQ+ LW    D L
Sbjct: 258 LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304



 Score = 32.7 bits (73), Expect = 0.80
 Identities = 16/45 (35%), Positives = 23/45 (51%)

Query: 210 SPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPY 254
           SP+GK + T   D  + +W+F       R  GHK  V+ V F P+
Sbjct: 27  SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 28/132 (21%), Positives = 59/132 (44%)

Query: 130 QLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD 189
           +L+   + F +        + PL + T  +  +N+  FSPD + +A  S D  +++++  
Sbjct: 51  RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 110

Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249
           + +   +++ +   +  + WS D + +V+G  D  + VW     ++     GH   V  V
Sbjct: 111 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 170

Query: 250 AFDPYTTSVEEG 261
            + P    V  G
Sbjct: 171 DWSPDGQRVASG 182



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 20/68 (29%), Positives = 38/68 (55%)

Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220
           A+ + A+S D + L   S D  L+V++  + +L   +  +   +  V WSPDG+ + +GG
Sbjct: 124 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 183

Query: 221 EDDLVTVW 228
           +D  + +W
Sbjct: 184 KDKCLRIW 191


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 6/109 (5%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221
           +N  A +P+ K LA  SQD   +++     +L G    +  GL CV +SP  + + T   
Sbjct: 482 INSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASA 541

Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSD 270
           D  + +W+  D   +    GH + V  VAF      V  G  +  SGSD
Sbjct: 542 DGTIKLWALQDFSCLKTFEGHDASVLKVAF------VSRGTQLLSSGSD 584



 Score = 35.8 bits (81), Expect = 0.095
 Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           FSP  + LA  S DG ++++         T + +   +L V +   G  +++ G D LV 
Sbjct: 529 FSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVK 588

Query: 227 VWSFV--DCRVIARGHGHKSW 245
           +W+    +C      H  K W
Sbjct: 589 LWTIKNNECVRTLDAHEDKVW 609



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 17/77 (22%), Positives = 35/77 (45%), Gaps = 2/77 (2%)

Query: 160 GALNEFAFSPDGKFLACVSQ--DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIV 217
           G ++  AF PD   L   S   D  +RV++         + +++  +  + +S DG  ++
Sbjct: 152 GVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTML 211

Query: 218 TGGEDDLVTVWSFVDCR 234
           + G D +  +W    C+
Sbjct: 212 SSGRDKICIIWDLQSCQ 228



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 12/110 (10%)

Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGT--MKSYFGGLLCVCWSPDGKYIV--TGGE 221
           AF P    LA    DG +RV+  D V  +GT   +   G +  V + PD   ++  +   
Sbjct: 116 AFDPTSTLLATGGCDGAVRVW--DIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173

Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271
           D  + VWS  D   +A    H S V+ +AF        +G  M  SG D+
Sbjct: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFS------ADGHTMLSSGRDK 217



 Score = 29.6 bits (65), Expect = 6.8
 Identities = 24/96 (25%), Positives = 37/96 (38%), Gaps = 1/96 (1%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKS-YFGGLLCVCWSPDGKYIVTGG 220
           +  F  SPD + L   S+   L  + +    +    K+ +   +  + + P    + TGG
Sbjct: 69  ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGG 128

Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTT 256
            D  V VW  V         G    V +VAF P  T
Sbjct: 129 CDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 28/101 (27%), Positives = 51/101 (50%), Gaps = 9/101 (8%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMK--------SYFGGLLCVCWSPDGKYIVT 218
           FSPDG++L   S DGF+ V+NF + ++   +K             +LC+C+S D + + T
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281

Query: 219 GGEDDLVTVWSFVDCRVIAR-GHGHKSWVSVVAFDPYTTSV 258
           G +D  + VW     + + R    H   V+ ++F   ++ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI 322



 Score = 36.6 bits (83), Expect = 0.055
 Identities = 13/30 (43%), Positives = 20/30 (66%)

Query: 206 CVCWSPDGKYIVTGGEDDLVTVWSFVDCRV 235
           C  +SPDG+Y+VTG  D  + VW+F   ++
Sbjct: 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKI 248



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 3/64 (4%)

Query: 136 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 195
           ++  +H  KS  T   L ++      +NE  F+ DG ++   S DG ++++N  + E   
Sbjct: 329 QTIRIHGLKSGKT---LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385

Query: 196 TMKS 199
           T KS
Sbjct: 386 TFKS 389



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 18/63 (28%), Positives = 32/63 (50%)

Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225
           A SP G+++ CV +D  L  F+  + +L  T+  +   ++ +   P    I T  ED L+
Sbjct: 449 ALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLL 508

Query: 226 TVW 228
            +W
Sbjct: 509 KLW 511


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 2/114 (1%)

Query: 150 NPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207
           N  LK+T+     A++   FSP+G++LA  S D  ++++     +   T+  +  G+  V
Sbjct: 34  NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93

Query: 208 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261
            WS D   +V+  +D  + +W     + +    GH ++V    F+P +  +  G
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS---PDGKYIVTGGEDD 223
           FSP+GK++   + D  L+++++   +   T   +     C+  +     GK+IV+G ED+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281

Query: 224 LVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253
           LV +W+     ++ +  GH   V   A  P
Sbjct: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHP 311



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 23/91 (25%), Positives = 43/91 (47%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221
           +++ A+S D   L   S D  L++++  S +   T+K +   + C  ++P    IV+G  
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 252
           D+ V +W     + +     H   VS V F+
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLC-VCWSPDGKYIVTGGEDDLV 225
           F+ DG  +   S DG  R+++  S +   T+       +  V +SP+GKYI+    D+ +
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238

Query: 226 TVWSFVDCRVIARGHGHKS 244
            +W +   + +    GHK+
Sbjct: 239 KLWDYSKGKCLKTYTGHKN 257


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 2/114 (1%)

Query: 150 NPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207
           N  LK+T+     A++   FSP+G++LA  S D  ++++     +   T+  +  G+  V
Sbjct: 34  NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93

Query: 208 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261
            WS D   +V+  +D  + +W     + +    GH ++V    F+P +  +  G
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS---PDGKYIVTGGEDD 223
           FSP+GK++   + D  L+++++   +   T   +     C+  +     GK+IV+G ED+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281

Query: 224 LVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253
           LV +W+     ++ +  GH   V   A  P
Sbjct: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHP 311



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 23/91 (25%), Positives = 43/91 (47%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221
           +++ A+S D   L   S D  L++++  S +   T+K +   + C  ++P    IV+G  
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 222 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 252
           D+ V +W     + +     H   VS V F+
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLC-VCWSPDGKYIVTGGEDDLV 225
           F+ DG  +   S DG  R+++  S +   T+       +  V +SP+GKYI+    D+ +
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238

Query: 226 TVWSFVDCRVIARGHGHKS 244
            +W +   + +    GHK+
Sbjct: 239 KLWDYSKGKCLKTYTGHKN 257


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 20/146 (13%)

Query: 124 TTAPHYQLLKQGES---FAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180
           T + H+ LL  G S     +     K  RN +   T    ++N   FSPD K LA  S D
Sbjct: 708 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT---NSVNHCRFSPDDKLLASCSAD 764

Query: 181 GFLRVFNFDSVELHGT--MKSYFGGL-----------LCVCWSPDGKYIVTGGEDDLVTV 227
           G L++++  S     +  +K +F  L            C  WS DG  I+   ++  + +
Sbjct: 765 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFL 823

Query: 228 WSFVDCRVIARGHGHKSWVSVVAFDP 253
           W+      +A   GH SWV  V F P
Sbjct: 824 WNTDSRSKVADCRGHLSWVHGVMFSP 849



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 8/164 (4%)

Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220
           A+    FS DG+ +A    D  L+VF  ++ E    +K++   +LC  +S D ++I T  
Sbjct: 617 AVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCS 676

Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 280
            D  V +W+ +   ++     H   V+   F   +  +     +  +GS + F  L    
Sbjct: 677 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-----LLATGSSDCFLKLWDLN 731

Query: 281 RDRANSTQSRLSKRNSTDSRPVSVTYR-FGSVGQDTQLCLWDLT 323
           +    +T       NS +    S   +   S   D  L LWD T
Sbjct: 732 QKECRNTM--FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773



 Score = 33.9 bits (76), Expect = 0.36
 Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 8/78 (10%)

Query: 151  PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVEL--------HGTMKSYFG 202
            PL +     G +   AFS D   LA    +G +R++N  + EL             ++ G
Sbjct: 1076 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1135

Query: 203  GLLCVCWSPDGKYIVTGG 220
             +  +C+SPDGK +++ G
Sbjct: 1136 WVTDLCFSPDGKMLISAG 1153



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 20/103 (19%), Positives = 44/103 (42%), Gaps = 8/103 (7%)

Query: 159  EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVT 218
            +G +     S D    +  S D   ++++FD +     ++ + G + C  +S D   + T
Sbjct: 1042 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1101

Query: 219  GGEDDLVTVWSFVD------CRVIAR--GHGHKSWVSVVAFDP 253
            G ++  + +W+  +      C  ++      H  WV+ + F P
Sbjct: 1102 GDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1144


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 20/146 (13%)

Query: 124 TTAPHYQLLKQGES---FAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180
           T + H+ LL  G S     +     K  RN +   T    ++N   FSPD K LA  S D
Sbjct: 697 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT---NSVNHCRFSPDDKLLASCSAD 753

Query: 181 GFLRVFNFDSVELHGT--MKSYFGGL-----------LCVCWSPDGKYIVTGGEDDLVTV 227
           G L++++  S     +  +K +F  L            C  WS DG  I+   ++  + +
Sbjct: 754 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFL 812

Query: 228 WSFVDCRVIARGHGHKSWVSVVAFDP 253
           W+      +A   GH SWV  V F P
Sbjct: 813 WNTDSRSKVADCRGHLSWVHGVMFSP 838



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 8/164 (4%)

Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220
           A+    FS DG+ +A    D  L+VF  ++ E    +K++   +LC  +S D ++I T  
Sbjct: 606 AVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCS 665

Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 280
            D  V +W+ +   ++     H   V+   F   +  +     +  +GS + F  L    
Sbjct: 666 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-----LLATGSSDCFLKLWDLN 720

Query: 281 RDRANSTQSRLSKRNSTDSRPVSVTYR-FGSVGQDTQLCLWDLT 323
           +    +T       NS +    S   +   S   D  L LWD T
Sbjct: 721 QKECRNTM--FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762



 Score = 33.9 bits (76), Expect = 0.36
 Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 8/78 (10%)

Query: 151  PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVEL--------HGTMKSYFG 202
            PL +     G +   AFS D   LA    +G +R++N  + EL             ++ G
Sbjct: 1065 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1124

Query: 203  GLLCVCWSPDGKYIVTGG 220
             +  +C+SPDGK +++ G
Sbjct: 1125 WVTDLCFSPDGKMLISAG 1142



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 20/103 (19%), Positives = 44/103 (42%), Gaps = 8/103 (7%)

Query: 159  EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVT 218
            +G +     S D    +  S D   ++++FD +     ++ + G + C  +S D   + T
Sbjct: 1031 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1090

Query: 219  GGEDDLVTVWSFVD------CRVIAR--GHGHKSWVSVVAFDP 253
            G ++  + +W+  +      C  ++      H  WV+ + F P
Sbjct: 1091 GDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1133


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 9/165 (5%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221
           +++   S DG+F    S DG LR+++  +         +   +L V +S D + IV+G  
Sbjct: 66  VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125

Query: 222 DDLVTVWSFVD-CRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 280
           D  + +W+ +  C+   +   H  WVS V F P        +P+  S   +    + +  
Sbjct: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP-----NSSNPIIVSCGWDKLVKVWNLA 180

Query: 281 RDRANSTQ-SRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 324
             +  +         N+    P       G  G+D Q  LWDL E
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASG--GKDGQAMLWDLNE 223



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 6/81 (7%)

Query: 154 KWTVGEGALNEFA----FSPDGKFLACVS--QDGFLRVFNFDSVELHGTMKSYFGGLLCV 207
           K+TV + + +E+     FSP+      VS   D  ++V+N  + +L      + G L  V
Sbjct: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198

Query: 208 CWSPDGKYIVTGGEDDLVTVW 228
             SPDG    +GG+D    +W
Sbjct: 199 TVSPDGSLCASGGKDGQAMLW 219


>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
          Length = 466

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 1/75 (1%)

Query: 159 EGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVELHGTMKSYFGGLLCVCWSPDGKYIV 217
           +G + + A+S DG FLA       + VF+  D    +     +   ++C+ WSPD ++  
Sbjct: 349 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 408

Query: 218 TGGEDDLVTVWSFVD 232
           +GG D +V VW+  D
Sbjct: 409 SGGMDMMVYVWTLSD 423



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 3/70 (4%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVE---LHGTMKSYFGGLLCVCWSPDGKYIVT 218
           +N   FSPDG   A  S DG + +++  + E     G  K++ GG+  + WSPD  ++++
Sbjct: 52  VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111

Query: 219 GGEDDLVTVW 228
              D    +W
Sbjct: 112 ASGDKTSKIW 121


>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
          Length = 606

 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 1/75 (1%)

Query: 159 EGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVELHGTMKSYFGGLLCVCWSPDGKYIV 217
           +G + + A+S DG FLA       + VF+  D    +     +   ++C+ WSPD ++  
Sbjct: 489 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 548

Query: 218 TGGEDDLVTVWSFVD 232
           +GG D +V VW+  D
Sbjct: 549 SGGMDMMVYVWTLSD 563



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 36/158 (22%), Positives = 72/158 (45%), Gaps = 19/158 (12%)

Query: 90  RVTCVKWVPGSESLFLVAHSS---GNMYLYNVEHTCGTTAPHYQLL-----KQGESFAVH 141
           ++  + W   S+ + +V       G ++L++   + G    H +++     KQ   + + 
Sbjct: 104 KIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLA 163

Query: 142 T-----CKSKSTRNPL-LKWTVGEGA--LNEFAFSPDGKFLACVSQDGFLRVFNFDSVE- 192
           T     C +     P   K+T+G+ +  +N   FSPDG   A  S DG + +++  + E 
Sbjct: 164 TGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK 223

Query: 193 --LHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVW 228
               G  K++ GG+  + WSPD  ++++   D    +W
Sbjct: 224 VCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261


>gi|148727341 serine/threonine kinase receptor associated protein
           [Homo sapiens]
          Length = 350

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 4/101 (3%)

Query: 131 LLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDS 190
           ++  G S A H+  S       +K       +N  +  P+ +FL    +D  L  ++++S
Sbjct: 199 VITYGRSIAFHSAVSLDP----IKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNS 254

Query: 191 VELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFV 231
            E   + K +FG + CV +SPDG+   +G ED  + +W  V
Sbjct: 255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTV 295


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 24/87 (27%), Positives = 46/87 (52%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           F P G+F+A  SQD  +++++          + +   + C+ +SPDGK++ +  +D  V 
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172

Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253
           +W     ++++   GH   V+VV F P
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHP 199



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 21/87 (24%), Positives = 42/87 (48%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           FSPDGK+LA  + D  +++++  + ++      + G +  V + P+   + +G  D  + 
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214

Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253
            W     +V++   G    V  V F+P
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNP 241



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 17/76 (22%), Positives = 38/76 (50%)

Query: 178 SQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIA 237
           SQ G +RV++ ++ ++  T+  +   +  + + P G+++ +G +D  + +W       + 
Sbjct: 82  SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF 141

Query: 238 RGHGHKSWVSVVAFDP 253
           R  GH   V  + F P
Sbjct: 142 RYRGHSQAVRCLRFSP 157



 Score = 30.0 bits (66), Expect = 5.2
 Identities = 34/156 (21%), Positives = 63/156 (40%), Gaps = 14/156 (8%)

Query: 171 GKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSF 230
           G+ LA    D  + +++ +      ++  +   +  V  +   + IV G +   + VW  
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92

Query: 231 VDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG---RDRANST 287
              +++    GHK+ +  + F PY   V  G       ++    D+   G   R R +S 
Sbjct: 93  EAAKILRTLMGHKANICSLDFHPYGEFVASGS----QDTNIKLWDIRRKGCVFRYRGHS- 147

Query: 288 QSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLT 323
           Q+    R S D + ++      S   D  + LWDLT
Sbjct: 148 QAVRCLRFSPDGKWLA------SAADDHTVKLWDLT 177


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 29/102 (28%), Positives = 47/102 (46%)

Query: 160 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 219
           G +N  AFSPDG+ L   S+DG +  +   S +L   +  + G +    +SPDG    + 
Sbjct: 22  GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA 81

Query: 220 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261
             D  V +W     + +    GH+  V  V+F P +  +  G
Sbjct: 82  SCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 30/116 (25%), Positives = 52/116 (44%), Gaps = 2/116 (1%)

Query: 148 TRNPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLL 205
           TR+  L W +G   G +    FSPDG   A  S D  +R+++    +    +K +   + 
Sbjct: 50  TRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVE 109

Query: 206 CVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 261
            V +SPD + + +GG D  V +W     +++    GH+  +    F P    +  G
Sbjct: 110 TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATG 165



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 26/106 (24%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 152 LLKWTVGE-GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVE---LHGTMKSYFGGLLCV 207
           +L+  VG   ++    FSP    LA  S D  + +++   V     H  ++ +   + C+
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198

Query: 208 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253
           C+S  G  + +G  D  + +W      ++ +  GH +WV  +AF P
Sbjct: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243



 Score = 33.1 bits (74), Expect = 0.61
 Identities = 17/61 (27%), Positives = 31/61 (50%)

Query: 162 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 221
           +   AFSPD  +LA       ++V++ ++ +   T+K          ++PDGK +V+G  
Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295

Query: 222 D 222
           D
Sbjct: 296 D 296


>gi|189571685 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 225
           FSP G  LA  S DG   ++N ++ ++   M+   G  + VC +SPD   + +G  D  V
Sbjct: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121

Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 284
            +W+    ++   G      ++  AF P  +    G         +D    LH  +    
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181

Query: 285 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 320
             T    S +  +D       +R  S GQD Q+ +W
Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%)

Query: 124 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 162
           T  PH  L  +  ++AVH C          S ST    + W    G +            
Sbjct: 43  TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100

Query: 163 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222
               FSPD   LA  + DG + ++N  S +L+       G L    +SP+G + VTG   
Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160

Query: 223 DLVTVW 228
             +TVW
Sbjct: 161 GDLTVW 166



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%)

Query: 165 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 222
           F+FS     LA  S D  +R+++  D  EL H  +K +   + C C+SP G  + +   D
Sbjct: 20  FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75

Query: 223 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 261
               +W+  + +++A       S V V  F P +T +  G
Sbjct: 76  GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115



 Score = 32.7 bits (73), Expect = 0.80
 Identities = 17/65 (26%), Positives = 32/65 (49%)

Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225
           AFS DG+ L   S D  + V++ ++  +  T+  +   +    ++P+   + TG  D  V
Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305

Query: 226 TVWSF 230
            +W F
Sbjct: 306 NIWQF 310



 Score = 30.0 bits (66), Expect = 5.2
 Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%)

Query: 156 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 211
           +V +G+L   AFSP+G F    S  G L V++ D +    + K++  G+ C  +S     
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194

Query: 212 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 265
           DG+       + + G+D  V +W      ++     +KS +S         +      M 
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254

Query: 266 FSGS--------DEDFQDLLH 278
            SGS        D + +++LH
Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275


>gi|189571683 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 225
           FSP G  LA  S DG   ++N ++ ++   M+   G  + VC +SPD   + +G  D  V
Sbjct: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121

Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 284
            +W+    ++   G      ++  AF P  +    G         +D    LH  +    
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181

Query: 285 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 320
             T    S +  +D       +R  S GQD Q+ +W
Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%)

Query: 124 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 162
           T  PH  L  +  ++AVH C          S ST    + W    G +            
Sbjct: 43  TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100

Query: 163 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222
               FSPD   LA  + DG + ++N  S +L+       G L    +SP+G + VTG   
Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160

Query: 223 DLVTVW 228
             +TVW
Sbjct: 161 GDLTVW 166



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%)

Query: 165 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 222
           F+FS     LA  S D  +R+++  D  EL H  +K +   + C C+SP G  + +   D
Sbjct: 20  FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75

Query: 223 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 261
               +W+  + +++A       S V V  F P +T +  G
Sbjct: 76  GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115



 Score = 32.7 bits (73), Expect = 0.80
 Identities = 17/65 (26%), Positives = 32/65 (49%)

Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225
           AFS DG+ L   S D  + V++ ++  +  T+  +   +    ++P+   + TG  D  V
Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305

Query: 226 TVWSF 230
            +W F
Sbjct: 306 NIWQF 310



 Score = 30.0 bits (66), Expect = 5.2
 Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%)

Query: 156 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 211
           +V +G+L   AFSP+G F    S  G L V++ D +    + K++  G+ C  +S     
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194

Query: 212 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 265
           DG+       + + G+D  V +W      ++     +KS +S         +      M 
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254

Query: 266 FSGS--------DEDFQDLLH 278
            SGS        D + +++LH
Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275


>gi|189571681 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 225
           FSP G  LA  S DG   ++N ++ ++   M+   G  + VC +SPD   + +G  D  V
Sbjct: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121

Query: 226 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 284
            +W+    ++   G      ++  AF P  +    G         +D    LH  +    
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181

Query: 285 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 320
             T    S +  +D       +R  S GQD Q+ +W
Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%)

Query: 124 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 162
           T  PH  L  +  ++AVH C          S ST    + W    G +            
Sbjct: 43  TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100

Query: 163 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222
               FSPD   LA  + DG + ++N  S +L+       G L    +SP+G + VTG   
Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160

Query: 223 DLVTVW 228
             +TVW
Sbjct: 161 GDLTVW 166



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%)

Query: 165 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 222
           F+FS     LA  S D  +R+++  D  EL H  +K +   + C C+SP G  + +   D
Sbjct: 20  FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75

Query: 223 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 261
               +W+  + +++A       S V V  F P +T +  G
Sbjct: 76  GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115



 Score = 32.7 bits (73), Expect = 0.80
 Identities = 17/65 (26%), Positives = 32/65 (49%)

Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 225
           AFS DG+ L   S D  + V++ ++  +  T+  +   +    ++P+   + TG  D  V
Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305

Query: 226 TVWSF 230
            +W F
Sbjct: 306 NIWQF 310



 Score = 30.0 bits (66), Expect = 5.2
 Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%)

Query: 156 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 211
           +V +G+L   AFSP+G F    S  G L V++ D +    + K++  G+ C  +S     
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194

Query: 212 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 265
           DG+       + + G+D  V +W      ++     +KS +S         +      M 
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254

Query: 266 FSGS--------DEDFQDLLH 278
            SGS        D + +++LH
Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 31/123 (25%), Positives = 53/123 (43%)

Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181
           C    P+   L  G +       S    N +  +T   G +   AFSP+GK+LA   +D 
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490

Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241
            L++++  S  L+  ++ +   +  + +SPD   I +   D+ V VW   +    A   G
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADG 550

Query: 242 HKS 244
             S
Sbjct: 551 SSS 553



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 22/87 (25%), Positives = 41/87 (47%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           F P+  +LA  S D  +R+++            + G +L + +SP+GKY+ + GED  + 
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLK 493

Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253
           +W      +     GH   ++ + F P
Sbjct: 494 LWDLASGTLYKELRGHTDNITSLTFSP 520



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 24/86 (27%), Positives = 37/86 (43%)

Query: 168 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 227
           SP   + A  S D   R+++FD          +   + CV + P+  Y+ TG  D  V +
Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452

Query: 228 WSFVDCRVIARGHGHKSWVSVVAFDP 253
           WS      +    GH+  V  +AF P
Sbjct: 453 WSAQQGNSVRLFTGHRGPVLSLAFSP 478



 Score = 36.6 bits (83), Expect = 0.055
 Identities = 49/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%)

Query: 160 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCW----SPDGKY 215
           G +    F  D   L   S+D  +R ++  S     T    + G     W    SP   Y
Sbjct: 343 GPVYSTRFLADSSGLLSCSEDMSIRYWDLGSF----TNTVLYQGHAYPVWDLDISPYSLY 398

Query: 216 IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQD 275
             +G  D    +WSF     +    GH + V  V F P +  +  G       +D+  + 
Sbjct: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGS------TDKTVR- 451

Query: 276 LLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRF-GSVGQDTQLCLWDLTEDILFPHQPLS 334
              +   + NS +     R    S   S   ++  S G+D +L LWDL    L+      
Sbjct: 452 --LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY-----K 504

Query: 335 RARTHT-NVMNAT-SPPAG 351
             R HT N+ + T SP +G
Sbjct: 505 ELRGHTDNITSLTFSPDSG 523


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 24/81 (29%), Positives = 38/81 (46%)

Query: 148 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207
           T   L  + +   A+N  +F P G +L   S D  L++ +     L  T+  + G    V
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239

Query: 208 CWSPDGKYIVTGGEDDLVTVW 228
            +S  G+Y  +GG D+ V VW
Sbjct: 240 AFSRTGEYFASGGSDEQVMVW 260



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%)

Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181
           C   +P  +L+             KS+R  +  +    G +    F P G  +A    D 
Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171

Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241
            ++V++  +  L    + +   +  + + P G Y++T   D  + +   ++ R++   HG
Sbjct: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 231

Query: 242 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271
           H+   + VAF         G+     GSDE
Sbjct: 232 HQGPATTVAFS------RTGEYFASGGSDE 255



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 28/138 (20%), Positives = 51/138 (36%)

Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180
           TC   +P   LL  G           + +     +      +    F  DG+     S D
Sbjct: 27  TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 86

Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240
             ++V+     +   ++  +   + C  +SPDG+ IV+  +D  V +W       +    
Sbjct: 87  KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 146

Query: 241 GHKSWVSVVAFDPYTTSV 258
            H  +V+ V F P  T +
Sbjct: 147 EHGGFVTYVDFHPSGTCI 164



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%)

Query: 154 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 213
           ++T  + A+    FSP G  LA  S+D  +R++  +        +++   +  V +  DG
Sbjct: 18  RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 77

Query: 214 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 273
           +  VT  +D  V VW+    + +     H +WV    F P      +G  +  +  D+  
Sbjct: 78  QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 131

Query: 274 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 333
           +      R+  +S           D  P        + G D  + +WD+    L  H  L
Sbjct: 132 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 189

Query: 334 SRA 336
             A
Sbjct: 190 HSA 192


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 24/81 (29%), Positives = 38/81 (46%)

Query: 148 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207
           T   L  + +   A+N  +F P G +L   S D  L++ +     L  T+  + G    V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277

Query: 208 CWSPDGKYIVTGGEDDLVTVW 228
            +S  G+Y  +GG D+ V VW
Sbjct: 278 AFSRTGEYFASGGSDEQVMVW 298



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%)

Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181
           C   +P  +L+             KS+R  +  +    G +    F P G  +A    D 
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 209

Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241
            ++V++  +  L    + +   +  + + P G Y++T   D  + +   ++ R++   HG
Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 269

Query: 242 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271
           H+   + VAF         G+     GSDE
Sbjct: 270 HQGPATTVAFS------RTGEYFASGGSDE 293



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 28/138 (20%), Positives = 51/138 (36%)

Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180
           TC   +P   LL  G           + +     +      +    F  DG+     S D
Sbjct: 65  TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124

Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240
             ++V+     +   ++  +   + C  +SPDG+ IV+  +D  V +W       +    
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184

Query: 241 GHKSWVSVVAFDPYTTSV 258
            H  +V+ V F P  T +
Sbjct: 185 EHGGFVTYVDFHPSGTCI 202



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%)

Query: 154 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 213
           ++T  + A+    FSP G  LA  S+D  +R++  +        +++   +  V +  DG
Sbjct: 56  RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115

Query: 214 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 273
           +  VT  +D  V VW+    + +     H +WV    F P      +G  +  +  D+  
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 169

Query: 274 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 333
           +      R+  +S           D  P        + G D  + +WD+    L  H  L
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 227

Query: 334 SRA 336
             A
Sbjct: 228 HSA 230



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 18/62 (29%), Positives = 27/62 (43%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           FS + K LA  S D  L V++            +   + CV +SP G  + +G  D  V 
Sbjct: 27  FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 86

Query: 227 VW 228
           +W
Sbjct: 87  IW 88



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%)

Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249
           S+E H   K +   + CV +S + K + +G  D  + VW         R  GHK  V+ V
Sbjct: 10  SLERH--FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67

Query: 250 AFDP 253
            F P
Sbjct: 68  NFSP 71


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 24/81 (29%), Positives = 38/81 (46%)

Query: 148 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 207
           T   L  + +   A+N  +F P G +L   S D  L++ +     L  T+  + G    V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277

Query: 208 CWSPDGKYIVTGGEDDLVTVW 228
            +S  G+Y  +GG D+ V VW
Sbjct: 278 AFSRTGEYFASGGSDEQVMVW 298



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%)

Query: 122 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 181
           C   +P  +L+             KS+R  +  +    G +    F P G  +A    D 
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 209

Query: 182 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 241
            ++V++  +  L    + +   +  + + P G Y++T   D  + +   ++ R++   HG
Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 269

Query: 242 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 271
           H+   + VAF         G+     GSDE
Sbjct: 270 HQGPATTVAFS------RTGEYFASGGSDE 293



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 28/138 (20%), Positives = 51/138 (36%)

Query: 121 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 180
           TC   +P   LL  G           + +     +      +    F  DG+     S D
Sbjct: 65  TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124

Query: 181 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 240
             ++V+     +   ++  +   + C  +SPDG+ IV+  +D  V +W       +    
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184

Query: 241 GHKSWVSVVAFDPYTTSV 258
            H  +V+ V F P  T +
Sbjct: 185 EHGGFVTYVDFHPSGTCI 202



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%)

Query: 154 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 213
           ++T  + A+    FSP G  LA  S+D  +R++  +        +++   +  V +  DG
Sbjct: 56  RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115

Query: 214 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 273
           +  VT  +D  V VW+    + +     H +WV    F P      +G  +  +  D+  
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 169

Query: 274 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 333
           +      R+  +S           D  P        + G D  + +WD+    L  H  L
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 227

Query: 334 SRA 336
             A
Sbjct: 228 HSA 230



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 18/62 (29%), Positives = 27/62 (43%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           FS + K LA  S D  L V++            +   + CV +SP G  + +G  D  V 
Sbjct: 27  FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 86

Query: 227 VW 228
           +W
Sbjct: 87  IW 88



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%)

Query: 190 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 249
           S+E H   K +   + CV +S + K + +G  D  + VW         R  GHK  V+ V
Sbjct: 10  SLERH--FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67

Query: 250 AFDP 253
            F P
Sbjct: 68  NFSP 71


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 23/89 (25%), Positives = 42/89 (47%)

Query: 161 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 220
           ++ + +F   GK LA  S D  +++++F   E   TM  +   +  V   P+G +IV+  
Sbjct: 152 SVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS 211

Query: 221 EDDLVTVWSFVDCRVIARGHGHKSWVSVV 249
            D  + +W       +    GH+ WV +V
Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGHREWVRMV 240



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/87 (24%), Positives = 40/87 (45%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           F P    +   S+D  ++V+++++ +   T+K +   +  + +   GK + +   D  + 
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175

Query: 227 VWSFVDCRVIARGHGHKSWVSVVAFDP 253
           +W F     I   HGH   VS VA  P
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMP 202



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 21/102 (20%), Positives = 40/102 (39%), Gaps = 20/102 (19%)

Query: 170 DGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPD----------------- 212
           DG  +A  S D  +RV+   + E    ++ +   + C+ W+P+                 
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304

Query: 213 ---GKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAF 251
              G ++++G  D  + +W       +    GH +WV  V F
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF 346



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 167 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 226
           F   GKF+   + D  LRV+++ +     T+ ++   +  + +     Y+VTG  D  V 
Sbjct: 346 FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVK 405

Query: 227 VWSFVDCR 234
           VW   +CR
Sbjct: 406 VW---ECR 410



 Score = 30.0 bits (66), Expect = 5.2
 Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 5/95 (5%)

Query: 171 GKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSF 230
           G FL   S+D  +++++  +     T+  +   +  V +   GK+I++  +D  + VW +
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367

Query: 231 VDCRVIARGHGHKSWVSVVAFD---PY--TTSVEE 260
            + R +   + H+ +V+ + F    PY  T SV++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 8/96 (8%)

Query: 166 AFSPDGKFLACVSQDGFLRVFN---FDSVE-----LHGTMKSYFGGLLCVCWSPDGKYIV 217
           + S +G +L   + D  +RV++   F   E       G + ++   LL   WSPDG  I 
Sbjct: 242 SLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIA 301

Query: 218 TGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 253
            G  D  V VW     R++ +  GH   ++ VAF P
Sbjct: 302 AGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 19/190 (10%)

Query: 144 KSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFN-FDSVELHGTMKSYFG 202
           +  S + P++  +  EG +    F P+G  LA    D  + ++N +   + + T+K + G
Sbjct: 51  RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110

Query: 203 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD 262
            ++ + ++ DG  + +   D  V VW       + R  GH S+V+             G 
Sbjct: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN------SCYPARRGP 164

Query: 263 PMEFSGSDEDFQDLLHFGRDRA-----NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQL 317
            +  +GSD+    L    +  A     N+ Q      N T  + +       S G D  +
Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQII-------SGGIDNDI 217

Query: 318 CLWDLTEDIL 327
            +WDL ++ L
Sbjct: 218 KVWDLRQNKL 227



 Score = 29.6 bits (65), Expect = 6.8
 Identities = 16/57 (28%), Positives = 29/57 (50%)

Query: 166 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 222
           ++SPDG  +A  S D F+ V++  S  +   +  + G +  V + PD   I++   D
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,528,487
Number of Sequences: 37866
Number of extensions: 1020741
Number of successful extensions: 4932
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 3905
Number of HSP's gapped (non-prelim): 960
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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