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Search of human proteins with 28195388
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28195388 RAB11 family interacting protein 4 (class II) [Homo
sapiens]
(637 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28195388 RAB11 family interacting protein 4 (class II) [Homo ... 1260 0.0
gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo sa... 386 e-107
gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo ... 336 3e-92
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 79 2e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 72 2e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 69 1e-11
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 66 9e-11
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 65 1e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 65 2e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 65 2e-10
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 64 4e-10
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 63 7e-10
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 63 9e-10
gi|38044112 restin isoform b [Homo sapiens] 62 1e-09
gi|4506751 restin isoform a [Homo sapiens] 62 1e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 62 2e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 62 2e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 62 2e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 61 3e-09
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 60 5e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 60 6e-09
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 60 6e-09
gi|7662230 ring finger protein 40 [Homo sapiens] 60 8e-09
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 60 8e-09
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 59 1e-08
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 59 1e-08
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 59 1e-08
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 59 1e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 59 1e-08
gi|215982794 myosin VA isoform 2 [Homo sapiens] 59 1e-08
>gi|28195388 RAB11 family interacting protein 4 (class II) [Homo
sapiens]
Length = 637
Score = 1260 bits (3260), Expect = 0.0
Identities = 637/637 (100%), Positives = 637/637 (100%)
Query: 1 MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKY 60
MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKY
Sbjct: 1 MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKY 60
Query: 61 LDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPT 120
LDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPT
Sbjct: 61 LDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPT 120
Query: 121 FADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLG 180
FADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLG
Sbjct: 121 FADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLG 180
Query: 181 GLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRT 240
GLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRT
Sbjct: 181 GLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRT 240
Query: 241 NVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPN 300
NVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPN
Sbjct: 241 NVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPN 300
Query: 301 RKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT 360
RKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT
Sbjct: 301 RKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT 360
Query: 361 NGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVE 420
NGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVE
Sbjct: 361 NGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVE 420
Query: 421 LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMD 480
LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMD
Sbjct: 421 LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMD 480
Query: 481 KLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREV 540
KLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREV
Sbjct: 481 KLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREV 540
Query: 541 ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDEL 600
ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDEL
Sbjct: 541 ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDEL 600
Query: 601 MEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH 637
MEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH
Sbjct: 601 MEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH 637
>gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo
sapiens]
Length = 756
Score = 386 bits (992), Expect = e-107
Identities = 250/621 (40%), Positives = 357/621 (57%), Gaps = 74/621 (11%)
Query: 20 RLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKYLDPNDLGRINFKDFCRGVF 79
RLR VF+ D DGF+R+E +G E+V+ L KYLDP+ LG I+F+DF +G+
Sbjct: 206 RLRAVFDALDGDGDGFVRIEDFIQFATVYG-AEQVKDLTKYLDPSGLGVISFEDFYQGIT 264
Query: 80 AMKGCE---ELLKDVLSVESAGTLPCAPEIPDCVE-QGSEVTGPTFADGELIPREPGFFP 135
A++ + + V S + L C E D V + +EVT + E E F
Sbjct: 265 AIRNGDPDGQCYGGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFT 324
Query: 136 EDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLGGLFLPEDKSLVHTPS 195
+ E+ TL PE E DS S E + + E D G L L + H S
Sbjct: 325 D--EDTSTLVHPELQPEGDADSAGGSAVPSE-CLDAMEEPDHG--ALLLLPGRPHPHGQS 379
Query: 196 MTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAG 255
+ T +I EE FEDYGEG + + +P + C LG S A
Sbjct: 380 VIT----------VIGGEEHFEDYGEGSEAELSPETLCN---------GQLGCS--DPAF 418
Query: 256 QTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHS 315
TP SP +++SS R L S
Sbjct: 419 LTP---------------------------------------SPTKRLSSKKVARYLHQS 439
Query: 316 SNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQL 375
+ + ED + ++ + DI +KV FLE++V ELE D+ G+ S+L+QEN QL
Sbjct: 440 GALTME--ALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQL 497
Query: 376 VHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTE 435
VHR + LEE +K+QE A + + EE RR +E K+EREK+ E+E L R+QQL+EEN+E
Sbjct: 498 VHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSE 557
Query: 436 LRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREA 495
LR+ LK+ E+L+EE+Q++ D +E +LRL +E + +RM D+L R +FQ+++EA
Sbjct: 558 LRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEA 617
Query: 496 TQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYK 555
TQELIEDLRK+LEHLQ+ KL+ E+ RGRS+S GL E+++RARE ELE EV+RLKQ+N
Sbjct: 618 TQELIEDLRKQLEHLQLLKLEAEQ-RRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRN 676
Query: 556 LRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLR 615
L++QN++LNGQI++LS+ AK+LF+ ++SLAAEI + SRDELMEA+++QEEINFRL+
Sbjct: 677 LKEQNEELNGQIITLSIQGAKSLFST-AFSESLAAEISSVSRDELMEAIQKQEEINFRLQ 735
Query: 616 QYMDKIILAILDHNPSILEIK 636
Y+D+II+AI++ NPSILE+K
Sbjct: 736 DYIDRIIVAIMETNPSILEVK 756
>gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo
sapiens]
Length = 460
Score = 336 bits (862), Expect = 3e-92
Identities = 215/525 (40%), Positives = 306/525 (58%), Gaps = 69/525 (13%)
Query: 112 QGSEVTGPTFADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGS 171
+ +EVT + E E F + E+ TL PE E DS S E + +
Sbjct: 5 KANEVTDSAYMGSESTYSECETFTD--EDTSTLVHPELQPEGDADSAGGSAVPSE-CLDA 61
Query: 172 PAEKDGGLGGLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSS 231
E D G L L + H S+ T +I EE FEDYGEG + + +P +
Sbjct: 62 MEEPDHG--ALLLLPGRPHPHGQSVIT----------VIGGEEHFEDYGEGSEAELSPET 109
Query: 232 PCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARL 291
C LG S A TP
Sbjct: 110 LCN---------GQLGCS--DPAFLTP--------------------------------- 125
Query: 292 KNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKV 351
SP +++SS R L S + + ED + ++ + DI +KV FLE++V
Sbjct: 126 ------SPTKRLSSKKVARYLHQSGALTME--ALEDPSPELMEGPEEDIADKVVFLERRV 177
Query: 352 TELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKL 411
ELE D+ G+ S+L+QEN QLVHR + LEE +K+QE A + + EE RR +E K+
Sbjct: 178 LELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKM 237
Query: 412 EREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDE 471
EREK+ E+E L R+QQL+EEN+ELR+ LK+ E+L+EE+Q++ D +E +LRL +E
Sbjct: 238 EREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEE 297
Query: 472 MDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLG 531
+ +RM D+L R +FQ+++EATQELIEDLRK+LEHLQ+ KL+ E+ RGRS+S GL
Sbjct: 298 QENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQ-RRGRSSSMGLQ 356
Query: 532 EFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAE 591
E+++RARE ELE EV+RLKQ+N L++QN++LNGQI++LS+ AK+LF+ ++SLAAE
Sbjct: 357 EYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFST-AFSESLAAE 415
Query: 592 IDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEIK 636
I + SRDELMEA+++QEEINFRL+ Y+D+II+AI++ NPSILE+K
Sbjct: 416 ISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 460
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 78.6 bits (192), Expect = 2e-14
Identities = 97/397 (24%), Positives = 173/397 (43%), Gaps = 70/397 (17%)
Query: 279 KKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDN 338
+K L L K L+ N+ K S GR +H + + G T L R+ ID
Sbjct: 328 EKETLEKKLRDANKELEKNTNKIKQLSQEKGR--LHQL-YETKEGETTRLIRE-IDKLKE 383
Query: 339 DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHE-------LEEMVKDQET 391
DI V ++ +L+ + ++ + K KLK+ T+L E ++M+K +
Sbjct: 384 DINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQE 443
Query: 392 TAEQALEEEARRHREAYGKLER---EKATEVELLNARVQQLE-------EENTELRTTVT 441
+ E E + R G+LE+ EK+ ++E+ +A++++LE E ELRT T
Sbjct: 444 SEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRT 503
Query: 442 RLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLR---QNRLEFQKEREATQE 498
++K LED LR +DE+ YK ++++ + QN L+ K + QE
Sbjct: 504 KVKC---------------LEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQE 548
Query: 499 L-------IEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQ 551
IE+L++E+E L D ++ G +R RE EL +RL
Sbjct: 549 QLQRGKQEIENLKEEVESLNSLINDLQKDIEG-----------SRKRESELLLFTERLTS 597
Query: 552 ENYKLRDQNDDLNGQILSLSLYEAK-------------NLFAAQTKAQSLAAEIDTASRD 598
+N +L+ +++ L Q +S E++ NL + K + L E +
Sbjct: 598 KNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQA 657
Query: 599 ELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEI 635
EL E + ++ ++ + D+++ H SI ++
Sbjct: 658 ELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDL 694
Score = 49.7 bits (117), Expect = 8e-06
Identities = 95/464 (20%), Positives = 184/464 (39%), Gaps = 86/464 (18%)
Query: 187 DKSLVHTPSMT--TSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRTNVYS 244
DK++ TP + + +L + + +S + NE + D C P+ E + N
Sbjct: 13 DKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNT-DKTLCQPNEHNNRIEAQENYIP 71
Query: 245 DLGSSVSSSAGQTPRKMRHVYNSELLDVYCS-QCCKKINLLNDLEARLKNLKANSPNRKI 303
D G S A NSE + + S K I+ N+ E ++ +
Sbjct: 72 DHGGGEDSCAKTDTGSE----NSEQIANFPSGNFAKHISKTNETEQKVTQILVE------ 121
Query: 304 SSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEK-------VSFLEKKVTELEN 356
+ SS F S + E + +S D D T+K VS E + E+E+
Sbjct: 122 ---------LRSSTFPES--ANEKTYSES--PYDTDCTKKFISKIKSVSASEDLLEEIES 168
Query: 357 DSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEE---EARRHREAYGKLER 413
+ L+ + ++ + H + E+ V+D+ E +++ E ++H+E + +
Sbjct: 169 ELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICS 228
Query: 414 EKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMD 473
EK E L R E + T+ +L+S+ E+L++E + D+L + K+ +
Sbjct: 229 EKDNLREELKKRT----ETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQ 284
Query: 474 -LYKRMMDKLRQ------------------------NRLEFQKEREATQELIEDLRKELE 508
L+K M ++ Q L+ +KE+E ++ + D KELE
Sbjct: 285 QLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELE 344
Query: 509 HLQMYKLDCERPGRGRSASSGLGEFNARAREV--ELEHEVKRLKQENYKLRDQNDDLNGQ 566
+ + L + R ++ E E RL +E KL+ +D+N
Sbjct: 345 -------------KNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLK---EDINSH 388
Query: 567 ILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEI 610
++ + A+N A+ + + + +L +A +E ++I
Sbjct: 389 VIKVKW--AQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQI 430
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 71.6 bits (174), Expect = 2e-12
Identities = 73/318 (22%), Positives = 144/318 (45%), Gaps = 32/318 (10%)
Query: 322 NGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHE 381
N S +++ C + TEK S +++K+ +L + NGDL KL++ + L
Sbjct: 285 NESLTMRLHETLKQCQDLKTEK-SQMDRKINQLSEE---NGDLSFKLREFASHLQQLQDA 340
Query: 382 LEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEV--ELLNARVQQLEEENTELRTT 439
L E+ ++ ++ LE++A+ +E L+ +K E E+L ++ QLEE ++L+
Sbjct: 341 LNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDN 400
Query: 440 VTRLKS-------QTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMD--KLRQNRLEFQ 490
+ K Q E L +E ++ +T L+ + EM +R KL R F+
Sbjct: 401 PPQEKGEVLGDVLQLETLKQEAATLA--ANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 491 KEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLK 550
+E++ LI DL+ + +L K + E+ + A + + L +++
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 551 QENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEI 610
QE L+ Q + Q+ A+ L + +Q L ++ ++L +LK++E+
Sbjct: 519 QELAGLKQQAKEKQAQL-------AQTLQQQEQASQGLRHQV-----EQLSSSLKQKEQ- 565
Query: 611 NFRLRQYMDKIILAILDH 628
+L++ +K DH
Sbjct: 566 --QLKEVAEKQEATRQDH 581
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/363 (19%), Positives = 162/363 (44%), Gaps = 40/363 (11%)
Query: 283 LLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITE 342
L + L+ + + LK + ++ + +QL ++ ++ D +++ + +
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615
Query: 343 KVSFLEKKVTELENDSLTNGDLK-SKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEA 401
K+ L++++ ++ N++ + ++ ++E +L +V EL+ V ET ++ E +A
Sbjct: 616 KLEILQQQL-QVANEARDSAQTSVTQAQREKAELSRKVEELQACV---ETARQEQHEAQA 671
Query: 402 R-RHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDR 460
+ E + E++KATE E + QL+E+ L+ + LK L+EE++R +D
Sbjct: 672 QVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES---LKVTKGSLEEEKRRAADA 728
Query: 461 LEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKER--------------EATQELIEDLRKE 506
LE+ + + + ++++ ++ R E ++ER EA Q E LR+E
Sbjct: 729 LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
Query: 507 LEHL----QMYKLDCERPGRGRSASSGLGEFNARAREVE----LEHEVKRLKQENYKLRD 558
L + +CE+ + +A E +++ E + + ++ LK+E K R
Sbjct: 789 LAEAMAAQHTAESECEQLVKEVAAWRERYE-DSQQEEAQYGAMFQEQLMTLKEECEKARQ 847
Query: 559 QNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYM 618
+ + ++ + + + Q + L A L AL++ +E R ++
Sbjct: 848 ELQEAKEKVAGIESHSELQISRQQNELAELHA--------NLARALQQVQEKEVRAQKLA 899
Query: 619 DKI 621
D +
Sbjct: 900 DDL 902
Score = 48.1 bits (113), Expect = 2e-05
Identities = 61/292 (20%), Positives = 125/292 (42%), Gaps = 38/292 (13%)
Query: 347 LEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETT------AEQALEEE 400
L+ +V LE + G ++KL E +L ++ D +++ A++ LE+
Sbjct: 432 LQARVEMLETE---RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
Query: 401 ARRHREAYGKLEREKATEVELLNARVQQLEEE-----------NTELRTTVTRLKSQTEK 449
++ H +E+ LNA +QQ ++E +L T+ + + ++
Sbjct: 489 SQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG 548
Query: 450 LDEERQRMSDRLEDTSLRLKDEMDL-------YKRMMDKLRQNRLEFQKEREATQELIED 502
L + +++S L+ +LK+ + + + + + R +ER+A + +E
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA 608
Query: 503 LRKE----LEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRD 558
L KE LE LQ +L R + +S A+ + EL +V+ L+ R
Sbjct: 609 LEKEKAAKLEILQQ-QLQVANEARDSAQTS---VTQAQREKAELSRKVEELQACVETARQ 664
Query: 559 QNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEI 610
+ + Q+ L L + ++ T+ + +A E D E ++ALKE ++
Sbjct: 665 EQHEAQAQVAELEL-QLRSEQQKATEKERVAQEKD--QLQEQLQALKESLKV 713
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/172 (23%), Positives = 76/172 (44%), Gaps = 9/172 (5%)
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALE--E 399
E+ S LE +LE + G +S L +L ++++ K ++ Q +
Sbjct: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
Query: 400 EARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSD 459
EA R LE E V +LN +V + E E+ EL+ V +++KL+E + +
Sbjct: 1219 EAERKNSLISSLEEE----VSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQA 1274
Query: 460 RLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQ 511
S R + + + LR+ E +K+R A++ L ++L + E +
Sbjct: 1275 ETASNSARAAERSSALREEVQSLRE---EAEKQRVASENLRQELTSQAERAE 1323
Score = 47.4 bits (111), Expect = 4e-05
Identities = 103/475 (21%), Positives = 183/475 (38%), Gaps = 93/475 (19%)
Query: 210 ISNEEQFEDYGEGDDVD---CAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHVYN 266
I N + E GE ++ A S E R + +S S+ A + +R
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ 1295
Query: 267 SELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTE 326
S L + Q NL +L ++ + + K F ++ S + ST+
Sbjct: 1296 S-LREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQ 1354
Query: 327 DLFRDSIDS---CDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELE 383
L + + + C E+ + ++ ELE G L+++L + +L + L
Sbjct: 1355 ALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELI-PLR 1413
Query: 384 EMVKDQETTAEQALEEEARRH------REAYGKLEREKA------------TEVELLNAR 425
+ V +QE TA+Q E+A ++A+G L E EVEL AR
Sbjct: 1414 QKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR 1473
Query: 426 VQ--------------QLEEENTELRTTVTRLKSQTEKLD--------------EERQRM 457
+ +L E E ++T L+ T K + EERQ++
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKL 1533
Query: 458 SDRLEDTSL----RLKDEMDLYKRMMD-----KLRQNRL--------EFQKEREATQELI 500
+ ++E + + K +L K++ D K++Q +L E Q+E + Q +
Sbjct: 1534 TAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQL 1593
Query: 501 EDLRKELEHLQM----YKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQ---EN 553
+L+ +L + YKL E+ A + + EL+ +++ L+Q EN
Sbjct: 1594 NELQAQLSQKEQAAEHYKLQMEKAKTHYDAK--------KQQNQELQEQLRSLEQLQKEN 1645
Query: 554 YKLRDQNDDLNGQILSLSLYEAKNLFAAQT----KAQSLAAEIDTASRDELMEAL 604
+LR + + L ++ L K A QT AQ + E A D+ + L
Sbjct: 1646 KELRAEAERLGHELQQAGL---KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Score = 45.1 bits (105), Expect = 2e-04
Identities = 80/356 (22%), Positives = 140/356 (39%), Gaps = 58/356 (16%)
Query: 301 RKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT 360
R+ ST Q M + G+ + R ++ E+ E++V L +
Sbjct: 958 RQFCSTQAALQAMERE--AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE--- 1012
Query: 361 NGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVE 420
G ++ L E L+ + +Q E A E GK ++E A
Sbjct: 1013 RGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK-DQELAKLRG 1071
Query: 421 LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMS---------------------- 458
L A++++LEE LR TV +LK Q K ++E S
Sbjct: 1072 LEAAQIKELEE----LRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRA 1127
Query: 459 --DRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLD 516
+LE + +++ D +R ++ R +R E E Q +E+ +EL H Q
Sbjct: 1128 EVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALAS 1187
Query: 517 CERP-----GRGRSASSGLGEFNARA----REVE--------LEHEVKRLKQENYKLRDQ 559
+R + + S E+ A+ +E E LE EV L ++ + +
Sbjct: 1188 AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE 1247
Query: 560 NDDLNGQILSLS-----LYEAKNLFAAQTKAQSL-AAEIDTASRDELMEALKEQEE 609
+ +L +++ S L E L A+T + S AAE +A R+E+ ++L+E+ E
Sbjct: 1248 SKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEV-QSLREEAE 1302
Score = 34.7 bits (78), Expect = 0.28
Identities = 54/272 (19%), Positives = 105/272 (38%), Gaps = 19/272 (6%)
Query: 368 LKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLER------EKATEVEL 421
LK+E + + E +E V E+ +E + + E + L R EK +
Sbjct: 838 LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897
Query: 422 LNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDK 481
L + L+E+ V RL++ K E+++ S L R D + + ++
Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW--LEEQ 955
Query: 482 LRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDC-----ERPGRGRSASSGLGEFNAR 536
+ Q +A + E + ELE L+ ++ E G+ + L + R
Sbjct: 956 QGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGR 1015
Query: 537 AREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTAS 596
A + +L E + +L++ ++ + +L A L + K Q LA
Sbjct: 1016 A-QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA-----KL 1069
Query: 597 RDELMEALKEQEEINFRLRQYMDKIILAILDH 628
R +KE EE+ ++Q +++ +H
Sbjct: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 68.9 bits (167), Expect = 1e-11
Identities = 61/289 (21%), Positives = 145/289 (50%), Gaps = 32/289 (11%)
Query: 342 EKVSFLEKKVTELENDSLTNGDL----KSKLKQENTQL---VHRVHELEEMVKDQETTAE 394
EK+ E+K+ E E ++ + K++++ + ++ ELEE + +QE E
Sbjct: 302 EKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 361
Query: 395 QALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEER 454
Q EE R+ E + E+ + E ++ + +++ E+ ++R ++ Q EK+ E+
Sbjct: 362 Q---EEKRQEEEKIREQEKRQEQEAKMWR-QEEKIREQEEKIREQEEMMQEQEEKMGEQE 417
Query: 455 QRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHL--QM 512
++M ++ E+ ++++ + +R +K+R+ + +++ E +E E ++++ E + Q
Sbjct: 418 EKMWEQEEE----MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQE 473
Query: 513 YKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSL 572
K+ CE+ + + E R +E ++ + K+++++ K+R+Q + + Q +
Sbjct: 474 GKM-CEQEAKMQEQ-----EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ--EEKM 525
Query: 573 YEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+E + Q + + + + R E E ++EQE RLRQ +K+
Sbjct: 526 WEQEEKMCEQ--EEKMQEQEEKMRRQE--EKMREQE---VRLRQQEEKM 567
Score = 55.8 bits (133), Expect = 1e-07
Identities = 59/283 (20%), Positives = 133/283 (46%), Gaps = 35/283 (12%)
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEA 401
E S K ++E + L N L + +++ + ++ E EE +++QE + EE+
Sbjct: 261 ELQSVSAKLQAQVEENELWNR-LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQ-EEKM 318
Query: 402 RRHREAYGKLEREKATEVELL---NARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMS 458
RR E + E + + E++ ++++LEE+ E +++ Q EK EE
Sbjct: 319 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE----KIREQEEKRQEE----- 369
Query: 459 DRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCE 518
+++ + R + E ++ R +K+R+ + +++ E QE E + ++ E + + + +
Sbjct: 370 EKIREQEKRQEQEAKMW-RQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQ 428
Query: 519 RPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNL 578
E R +E ++ + K+++++ K+R+Q + + Q + E K +
Sbjct: 429 EQ-----------EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK-M 476
Query: 579 FAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+ K Q + + R E E ++EQE+ ++R+ +KI
Sbjct: 477 CEQEAKMQE---QEEKMRRQE--EKIREQEK---KIREQEEKI 511
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/211 (18%), Positives = 97/211 (45%), Gaps = 30/211 (14%)
Query: 348 EKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREA 407
E+K+ E E ++ + +++ + ++ E EE +++QE + +EE R +E
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRR--QEEKIREQEK 446
Query: 408 YGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLR 467
+ + EK E E + +Q+ EE+ E + +++ ++ +E+ +R +++ + +
Sbjct: 447 KIREQEEKIREQEEM---MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
Query: 468 LKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSAS 527
++++ +K+R+ Q++ E E E + ++ E +Q
Sbjct: 504 IREQ-------EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ-------------- 542
Query: 528 SGLGEFNARAREVELEHEVKRLKQENYKLRD 558
E R +E ++ + RL+Q+ K+++
Sbjct: 543 ----EEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 32.7 bits (73), Expect = 1.0
Identities = 58/295 (19%), Positives = 121/295 (41%), Gaps = 42/295 (14%)
Query: 348 EKKVTELEN-DSLTNGDLKSKLKQENTQLVHRV---HELEEMVKDQETTAEQALEEEARR 403
+KK+ N ++ T+G S ++ H+ ELE V+ Q E +
Sbjct: 75 KKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMAL 134
Query: 404 H--REAYGKLEREKATEVELLNARVQ---QLEEENTELRTTVTRLKSQTEKLDEERQRMS 458
+ + A +LE E + L+ + +LE+ + + T + E+L +ER +S
Sbjct: 135 YYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALS 194
Query: 459 DRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEH----LQMYK 514
L ++ ++ + ++ +KL+ + E+ Q +++L+++LE L +
Sbjct: 195 LELYRNTITDEELKEKNAKLQEKLQL----VESEKSEIQLNVKELKRKLERAKLLLPQQQ 250
Query: 515 LDCERPGRGRSASSGLGEFNARAREVEL-------------------EHEVKRLKQENYK 555
L E G+ S + A+ E EL + ++++++ K
Sbjct: 251 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEK 310
Query: 556 LRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEI 610
+R+Q + + Q + E K + + + E + R EL E + EQE+I
Sbjct: 311 IREQEEKMRRQEEMMWEKEEK-----MRRQEEMMWEKEEKIR-ELEEKMHEQEKI 359
Score = 29.6 bits (65), Expect = 8.9
Identities = 19/77 (24%), Positives = 38/77 (49%), Gaps = 2/77 (2%)
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEA 401
EK+ EKK+ E E ++ + +++ + ++ E EE +++QE + +EE
Sbjct: 495 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR--QEEK 552
Query: 402 RRHREAYGKLEREKATE 418
R +E + + EK E
Sbjct: 553 MREQEVRLRQQEEKMQE 569
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 66.2 bits (160), Expect = 9e-11
Identities = 77/348 (22%), Positives = 141/348 (40%), Gaps = 67/348 (19%)
Query: 338 NDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQAL 397
N +T+ + LE++V +LE L L++ +L + +E D E +Q
Sbjct: 1022 NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLN 1081
Query: 398 EEEARRHREA---YGKLEREKATEVEL------LNARVQQLEEENTELRTTVTRLKSQTE 448
E+ ++ E GK+E E+A ++L L AR+++LEEE R + + + Q
Sbjct: 1082 EKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1141
Query: 449 KLDEERQRMSDRLEDTSLRLKDEMDLYKR------------------------------- 477
L E + +S+RLE+ ++++ K+
Sbjct: 1142 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHA 1201
Query: 478 --------MMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSG 529
+D L++ + + +KE+ + I DL +E + K + E+ R+
Sbjct: 1202 DSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEK--MCRTLEDQ 1259
Query: 530 LGEFNARAREV-----ELEHEVKRLKQENYKLRDQNDDLNGQILSLS---------LYEA 575
L E + E EL + RL E+ + Q D+ + + LS + E
Sbjct: 1260 LSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL 1319
Query: 576 KNLFAAQTKAQSLAAEIDTASR---DELMEALKEQEEINFRLRQYMDK 620
K +TKA+S A ++R D L E +E++E L++ M K
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367
Score = 54.3 bits (129), Expect = 3e-07
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 26/260 (10%)
Query: 364 LKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHR--EAYGKLEREK---ATE 418
+K LK T+ E+ M ++ E T E+ + EA+R E L +EK +
Sbjct: 840 IKPLLKSAETE-----KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 419 VELLNARVQQLEEENTELRTTVTRLKSQTEKLDE---ERQRMSDRLEDTSLRLKDEMDLY 475
V+ + EE +L T +L+++ +++ E + + ++ L +L+DE
Sbjct: 895 VQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 476 KRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQ--MYKLDCERPGRGRSASSGLGEF 533
K+ +D L + +KE+ AT+ +++L +E+ L + KL E+ + L +
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014
Query: 534 NARAREVELEHEVKRLKQENYKLRDQNDDLNGQI-----LSLSLYEAKNLFAAQTKAQSL 588
E +V L + KL Q DDL G + L + L AK K
Sbjct: 1015 QME------EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 589 AAEIDTASRDELMEALKEQE 608
+ + +L E LK++E
Sbjct: 1069 STMDTENDKQQLNEKLKKKE 1088
Score = 51.6 bits (122), Expect = 2e-06
Identities = 55/287 (19%), Positives = 127/287 (44%), Gaps = 12/287 (4%)
Query: 339 DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALE 398
++ EK+ L ++ +L+ D + ++ QL+ +LE +K+ AE E
Sbjct: 876 ELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAED--E 933
Query: 399 EEARRHREAYGKLEREKATE----VELLNARVQQLEEENTELRTTVTRLKSQTEKLDEER 454
EE A + ++ +E ++ L + ++E+E V L + LDE
Sbjct: 934 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 993
Query: 455 QRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYK 514
+++ E +L+ + L M++ + N L K + ++ ++DL LE +
Sbjct: 994 AKLTK--EKKALQEAHQQTLDDLQMEEDKVNTL--TKAKTKLEQQVDDLEGSLEQEKKLC 1049
Query: 515 LDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYE 574
+D ER R L + + E + + ++LK++ +++ + + + +L++
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDE-QALAIQL 1108
Query: 575 AKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
K + Q + + L EI+ A R +A K++ +++ L + +++
Sbjct: 1109 QKKIKELQARIEELEEEIE-AERASRAKAEKQRSDLSRELEEISERL 1154
Score = 45.8 bits (107), Expect = 1e-04
Identities = 63/347 (18%), Positives = 134/347 (38%), Gaps = 33/347 (9%)
Query: 286 DLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVS 345
+LEA K ++ S A+ L H N + + +D+TE+++
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEI--------SDLTEQIA 1521
Query: 346 FLEKKVTELENDSL----TNGDLKSKLKQENTQLVH----------RVHELEEMVKDQET 391
K + ELE +L++ L++ L H +++++ + +
Sbjct: 1522 EGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIA 1581
Query: 392 TAEQALEEEARRHREAYGKLEREKATEVELLNARV---QQLEEENTELRTTVTRLKSQTE 448
++ L++ R H ++ E+ N + +++E + E+ + Q
Sbjct: 1582 EKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAA 1641
Query: 449 KLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELE 508
+ + L+DT L L D + R D L++ ++ Q +E+LR LE
Sbjct: 1642 EALRNLRNTQGILKDTQLHLDDAI----RGQDDLKEQLAMVERRANLMQAEVEELRASLE 1697
Query: 509 HLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQIL 568
+ + E+ S L + L + K+L+ + +++ + +D+ +
Sbjct: 1698 RTERGRKMAEQELLDASERVQL----LHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 1753
Query: 569 SLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLR 615
+ K + A A+ L E DT++ E M+ EQ + +LR
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1800
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/291 (21%), Positives = 122/291 (41%), Gaps = 38/291 (13%)
Query: 338 NDITEKVSFLEKKVTE-LENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQA 396
N++ +++ ++ E L N T G LK +TQL L++ ++ Q+ EQ
Sbjct: 1627 NEMEIQLNHANRQAAEALRNLRNTQGILK------DTQL-----HLDDAIRGQDDLKEQL 1675
Query: 397 LEEEARRH------REAYGKLER----EKATEVELLNA--RVQQLEEENTELRTTVTRLK 444
E R + E LER K E ELL+A RVQ L +NT L T +L+
Sbjct: 1676 AMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLE 1735
Query: 445 SQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNR---LEFQKEREATQELIE 501
+ ++ E + + + + K + M ++L++ + ++ ++ ++ ++
Sbjct: 1736 TDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1795
Query: 502 DLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQ-ENYKLRDQN 560
DL+ L+ + L + + + AR RE+E E E ++ E K ++
Sbjct: 1796 DLQLRLDEAEQLAL--------KGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKH 1847
Query: 561 DDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEIN 611
+ ++ + + KN+ Q L ++ R E +EQ +N
Sbjct: 1848 ERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ--AEEAEEQSNVN 1896
Score = 44.3 bits (103), Expect = 3e-04
Identities = 62/274 (22%), Positives = 114/274 (41%), Gaps = 46/274 (16%)
Query: 363 DLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYG------------- 409
+LK +L++E H L+ D + EQ EE+ + G
Sbjct: 1318 ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT 1377
Query: 410 KLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLK 469
K E + E L ++L + + V + S+ L++ +QR+ + +ED + ++
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVE 1437
Query: 470 DE------MDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRG 523
+D +R DK+ E++++ E TQ +E +KE
Sbjct: 1438 RSNAACIALDKKQRNFDKV---LAEWKQKYEETQAELEASQKE----------------S 1478
Query: 524 RSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQIL--SLSLYE----AKN 577
RS S+ L + A E L+H ++ LK+EN L+ + DL QI ++E K
Sbjct: 1479 RSLSTELFKVK-NAYEESLDH-LETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQ 1536
Query: 578 LFAAQTKAQSLAAEIDTASRDELMEALKEQEEIN 611
L +++ Q+ E + + E + L+ Q E+N
Sbjct: 1537 LDHEKSELQTSLEEAEASLEHEEGKILRIQLELN 1570
Score = 37.7 bits (86), Expect = 0.033
Identities = 56/251 (22%), Positives = 95/251 (37%), Gaps = 20/251 (7%)
Query: 367 KLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARV 426
K K E TQ + E E + EE+ H E L+RE L +
Sbjct: 1461 KQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET---LKRENKN----LQQEI 1513
Query: 427 QQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNR 486
L E+ E + L+ ++LD E+ + LE+ L+ E R+ +L Q +
Sbjct: 1514 SDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 487 LEFQKEREATQELIEDLRKELEHLQMYK-----LDCERPGRG---RSASSGLGEFNARAR 538
E ++ E ++ L++ HL++ + LD E R R G+ N
Sbjct: 1574 SEIDRKIAEKDEELDQLKR--NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN--EM 1629
Query: 539 EVELEHEVKRLKQENYKLRDQNDDLNGQILSL-SLYEAKNLFAAQTKAQSLAAEIDTASR 597
E++L H ++ + LR+ L L L ++ Q A + A
Sbjct: 1630 EIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEV 1689
Query: 598 DELMEALKEQE 608
+EL +L+ E
Sbjct: 1690 EELRASLERTE 1700
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 65.5 bits (158), Expect = 1e-10
Identities = 73/293 (24%), Positives = 136/293 (46%), Gaps = 34/293 (11%)
Query: 348 EKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREA 407
E+ +L N N L+ KL L R+ ELEE K+ Q EEE + R+
Sbjct: 315 EEMNAKLANQESHNRQLRLKL----VGLTQRIEELEETNKNL-----QKAEEELQELRDK 365
Query: 408 YGKLEREKAT---EVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSD-RLED 463
K E ++ EVE L RV ++E ++ E+ T ++ + +KL EE + RLE
Sbjct: 366 IAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEV 425
Query: 464 TSLR-----LKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCE 518
L+ L+ + + + + Q L +KE+ T++L+ +L E+ ++ +L+C
Sbjct: 426 EKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNEL--EVVKSRVKELECS 483
Query: 519 RPGRGRSASSGLGEFNARAREV------ELEHEVKRLKQENYKLRDQNDDLN---GQILS 569
R A L + + + E ++ ++++KQE K+ N + G+++
Sbjct: 484 E-SRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMD 542
Query: 570 LS---LYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMD 619
++ + E+K L +++ + + T RDEL+ LK +EE + L +D
Sbjct: 543 VTEKLIEESKKLLKLKSEMEEKVYNL-TRERDELIGKLKSEEEKSSELSCSVD 594
Score = 53.1 bits (126), Expect = 7e-07
Identities = 64/271 (23%), Positives = 132/271 (48%), Gaps = 51/271 (18%)
Query: 286 DLEARLKNLKANSPNRKISSTAFGRQLMH----SSNFSSSNGSTEDLFRDSI--DSCDND 339
++ A+L N ++++ ++ +++ + N + ++L RD I C N
Sbjct: 316 EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQEL-RDKIAKGECGNS 374
Query: 340 -ITEKVSFLEKKVTELE--NDSLTNGD-----LKSKLKQE---NTQLVHRVHELEEMVKD 388
+ +V L K+V E+E ++ +T + L+ KL++E + +L V +L++ + +
Sbjct: 375 SLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSE 434
Query: 389 QETTAEQALEEEARRHREAYGKLEREK------ATEVELLNARVQQLE-------EENTE 435
E E+A + + + LE+EK E+E++ +RV++LE +
Sbjct: 435 LEKL-EEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELS 493
Query: 436 LRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQN-RLEFQKERE 494
L+ +T+LKS T L +ER+ M ++++ +R +D L +N ++E K +
Sbjct: 494 LKDDLTKLKSFTVMLVDERKNMMEKIKQE-----------ERKVDGLNKNFKVEQGKVMD 542
Query: 495 ATQELIED------LRKELEHLQMYKLDCER 519
T++LIE+ L+ E+E ++Y L ER
Sbjct: 543 VTEKLIEESKKLLKLKSEMEE-KVYNLTRER 572
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 49/291 (16%)
Query: 349 KKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAY 408
+ V ELEN+ + D +K L L+++++ ++ + +E A+R +
Sbjct: 178 RTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLR 237
Query: 409 GKLER----------EKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQ--- 455
+L + E+ +E L + Q++++ +LR +LK+ T K E+RQ
Sbjct: 238 DELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLL 297
Query: 456 -----------RMSDRLEDTSLRLKDEMDLYKRM----------MDKLRQNRLEFQKERE 494
R S E+ + +L ++ +++ +++L + QK E
Sbjct: 298 KLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE 357
Query: 495 ATQELIEDLRK----------ELEHLQMYKLDCERPGRGRSASSGLGEF-NARAREVELE 543
QEL + + K E+E+L+ L+ E G+ + + R + E E
Sbjct: 358 ELQELRDKIAKGECGNSSLMAEVENLRKRVLEME--GKDEEITKTESQCRELRKKLQEEE 415
Query: 544 HEVKRLKQENYKLRDQNDDLN--GQILSLSLYEAKNLFAAQTKAQSLAAEI 592
H K L+ E KL+ + +L + S S E L K ++L ++
Sbjct: 416 HHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDL 466
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 34/306 (11%)
Query: 321 SNGSTEDLFRDSIDSCDNDITEKVSFLEKKV-----------TELENDSLTNGDLKSKLK 369
++G E + S++ D+ + +S +E ++ TE + S
Sbjct: 61 TSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEP 120
Query: 370 QENTQLVHRVHELEEMVKDQETTAEQALEEEAR---RHREAYGKLEREKATEVELLNARV 426
++ +++HR L + E E+ + E R + +E Y ++ + + V
Sbjct: 121 EKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTV 180
Query: 427 QQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLE-DTSLRLKDEMDLYKRM------M 479
+LE E + + + T L++ER+R+ LE + + + + E + KR+ +
Sbjct: 181 YELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL 240
Query: 480 DKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARARE 539
KL+ L ER+ E + ++++ L + E + ++ S E
Sbjct: 241 VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE 300
Query: 540 VELEHEVKRLKQE----NYKLRDQ---NDDLNGQILSLS-----LYEA-KNLFAAQTKAQ 586
V+ EH+ R QE N KL +Q N L +++ L+ L E KNL A+ + Q
Sbjct: 301 VDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQ 360
Query: 587 SLAAEI 592
L +I
Sbjct: 361 ELRDKI 366
Score = 37.0 bits (84), Expect = 0.056
Identities = 51/221 (23%), Positives = 97/221 (43%), Gaps = 22/221 (9%)
Query: 315 SSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTEL--ENDSLTNGDLKSKLKQEN 372
+ NF G D+ I+ + K S +E+KV L E D L G LKS+ ++++
Sbjct: 530 NKNFKVEQGKVMDVTEKLIEESKKLLKLK-SEMEEKVYNLTRERDELI-GKLKSE-EEKS 586
Query: 373 TQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLE---REKATEVELLNARVQQL 429
++L V L++ + E + +R+ E + +E E+E L R+QQL
Sbjct: 587 SELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQL 646
Query: 430 EEENTELRTTVTRLKSQTEKLDEERQR---MSDRLEDTSLRLK-----DEMDLYKRMMDK 481
E +L T +K E+ + +S +LE+ ++ ++ ++ + +
Sbjct: 647 EVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAEL 706
Query: 482 LRQNRLEFQKER------EATQELIEDLRKELEHLQMYKLD 516
+ RLE K R +A +E I +L + + L ++D
Sbjct: 707 RHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVD 747
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 64.7 bits (156), Expect = 2e-10
Identities = 84/338 (24%), Positives = 143/338 (42%), Gaps = 63/338 (18%)
Query: 330 RDSIDSCDN---DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHEL---- 382
+ S+ +C N D+ ++ + LEK + L +S + L+QEN L V L
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI---LEQENEHLNQTVSSLRQRS 574
Query: 383 ----EEMVKDQETTAEQALEEEARRHREAYGKLE-------------REKATEVELLNAR 425
E VKD E + L E + K+E +EK E L
Sbjct: 575 QISAEARVKDIEKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 426 VQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRM---MDKL 482
+ LE+EN L+ +T LK EK++ Q S+ LE + +LK +D +K + ++ L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKNLTFQLESL 692
Query: 483 RQNRLEFQKEREATQELIEDLR-------------KELEH--------LQMYKLDCERPG 521
+ + +E + +E L+ KELE L++ K ++
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 522 RGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRD---QNDDLNGQILSLSLYEAKNL 578
R + GL N R ++ LE+ K+++Q +L+D +N L + L + +K L
Sbjct: 753 RLEVSYQGLDIENQRLQKT-LENSNKKIQQLESELQDLEMENQTLQKNLEELKI-SSKRL 810
Query: 579 FAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQ 616
+ + +SL E +D+ K+ E+ N RLRQ
Sbjct: 811 EQLEKENKSLEQETSQLEKDK-----KQLEKENKRLRQ 843
Score = 60.5 bits (145), Expect = 5e-09
Identities = 72/313 (23%), Positives = 141/313 (45%), Gaps = 38/313 (12%)
Query: 325 TEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT---------------NGDLKSKLK 369
T +L S +++ E S K+ E+EN SLT N K++
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 370 QENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQL 429
+EN +L +V LE + QE + Q + ++ + +LE+ T E +++ L
Sbjct: 498 KENQRLSKKVEILENEIV-QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 430 EEENTELRTTVTRLKSQTE--------KLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDK 481
E+EN L TV+ L+ +++ +++E + + + +++TS +L +++ KR + K
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL-SKIEFEKRQIKK 615
Query: 482 LRQNRLEFQKEREATQELIEDLRKELEHLQM----YKLDCERPGRGRSASSGLGEFNARA 537
++ E + E + + L KE E LQ K+ CE+ +S L N +
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 538 REV-----ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEI 592
++ L +++ L++EN +L ++N +L + SL K AQ + ++ E
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK---MAQLQLENKELES 732
Query: 593 DTASRDELMEALK 605
+ + +E LK
Sbjct: 733 EKEQLKKGLELLK 745
Score = 53.1 bits (126), Expect = 7e-07
Identities = 74/357 (20%), Positives = 151/357 (42%), Gaps = 31/357 (8%)
Query: 245 DLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNL--KANSPNRK 302
D ++V++ + +V++ + ++V LL ++ LK L + + +
Sbjct: 151 DTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSET 210
Query: 303 ISSTAFGRQLMH-----SSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELEND 357
I + R +H SS+ S GS +S ++ + + + + ELE
Sbjct: 211 IIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEK 270
Query: 358 SLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREA-YGKLE---- 412
+ D K +L+Q +L E ++ D + E +A R + KLE
Sbjct: 271 TEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVS 330
Query: 413 --REKATEVELLNARVQQLEEENTELRTTVTRLKSQTE----------KLDEERQRMSDR 460
+E+ ++E ARV++L+E+N L T T L+ Q E +L++E ++ +
Sbjct: 331 RYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 461 LEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERP 520
L D + E D+ ++ +++L + + + ++ + + L ELE + E P
Sbjct: 391 LHDMEM----ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 521 GRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKN 577
+S + E + +R ++LE E + L + +LR D + G + E +N
Sbjct: 447 --QKSLGHEVNELTS-SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Score = 46.6 bits (109), Expect = 7e-05
Identities = 68/294 (23%), Positives = 124/294 (42%), Gaps = 73/294 (24%)
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEA 401
E++ K++ +LE ++ + S+L+++ QL L + + ++TT E+
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE------ 854
Query: 402 RRHREAYGKLEREKAT---EVELLN---ARVQQLEEENTEL--------------RTTVT 441
+ G LE+E T E+ + R+++LE+EN EL R +
Sbjct: 855 --NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
Query: 442 RLKSQTEKLDEERQRMSDRLEDTSLR----LKDEMDL----YKRMMDKLR---QNRLEFQ 490
K +T++++ + ++++ LE L L DE YK + KL + LE +
Sbjct: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK 972
Query: 491 KEREATQELI--------EDLRKELEHLQM-YKLDCERPGRGRSASSG---LGEFNARAR 538
+E+ A E + LR+EL+ ++ Y+ +R R S GE N R
Sbjct: 973 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 539 EVE----------------------LEHEVKRLKQENYKLRDQNDDLNGQILSL 570
E + L+ E + LK + +L QN++L QIL+L
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086
Score = 44.3 bits (103), Expect = 3e-04
Identities = 82/380 (21%), Positives = 159/380 (41%), Gaps = 58/380 (15%)
Query: 278 CKKINLLNDLEARLKNLKANSPNRKISST--AFGRQLMHSSNFSSSNGSTEDL---FRDS 332
C+KI L +N + NRK+ T +F + N ++ R +
Sbjct: 655 CEKIEALEQ-----ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 333 IDSCDNDITEKVSF-LEKKVTELENDSLTNGD--LKSKLKQ-ENTQLVHRVHELEE--MV 386
++S + LE K E E + L G LK+ K+ E ++ ++ ++E +
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 387 KDQETTAE--QALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLK 444
K E + + Q LE E + E + ++ E+++ + R++QLE+EN L ++L+
Sbjct: 770 KTLENSNKKIQQLESELQ-DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 445 SQTEKLDEERQRMSDRLE--DTSLR---------------LKDEMDLYKRMMDKLRQNRL 487
++L++E +R+ + E DT+L L E+ +YK +L+
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK---- 884
Query: 488 EFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVK 547
E +KE +EL++ +++ L + D S L +L HE++
Sbjct: 885 ELEKE---NKELVKRATIDIKTLVTLREDL--------VSEKLKTQQMNNDLEKLTHELE 933
Query: 548 RLKQENYKL---RDQNDDLNGQILSLSLYEA--KNLFAAQTKAQSLAAEID--TASRDEL 600
++ +L DD ++L L K+L + K +L A ++ T +L
Sbjct: 934 KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL 993
Query: 601 MEALKEQEEINFRLRQYMDK 620
+ LK ++ L+Q D+
Sbjct: 994 RQELKTVKKNYEALKQRQDE 1013
Score = 43.5 bits (101), Expect = 6e-04
Identities = 63/300 (21%), Positives = 127/300 (42%), Gaps = 19/300 (6%)
Query: 333 IDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETT 392
+++ +N++ ++ L+++ L+ + T +KL+ EN+ L + L Q
Sbjct: 1072 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ-NAQLLI 1130
Query: 393 AEQALEEEAR---RHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEK 449
+ +LE E + RE L + E L ++ E L + LKS +
Sbjct: 1131 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1190
Query: 450 LDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEH 509
L+ E + + DR L+ K +++ ++M+ ++ L K E + L E +
Sbjct: 1191 LEVEHRDLEDRYNQL-LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249
Query: 510 L-----QMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLN 564
L Q+ K ++ S L N++ + LE E +LK++ +L + LN
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1307
Query: 565 GQILSLSLYEAKNLFAAQTKAQSLAAEIDT---ASRDELMEALKEQEEINFRLRQYMDKI 621
Q LS + + + + L +I T +R L + ++ ++ + RQY+DK+
Sbjct: 1308 NQCELLSQLKGN----LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363
Score = 37.7 bits (86), Expect = 0.033
Identities = 34/140 (24%), Positives = 62/140 (44%), Gaps = 6/140 (4%)
Query: 355 ENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLERE 414
END L + S+L +E T+++ H+ + + + + LE E + +E Y +L+
Sbjct: 1246 ENDRLNH--TYSQLLKE-TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
Query: 415 KA---TEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDE 471
+ ELL+ LEEEN L + L Q L E+ D + D+
Sbjct: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
Query: 472 MDLYKRMMDKLRQNRLEFQK 491
++ +R +KL + ++ K
Sbjct: 1363 LNELRRQKEKLEEKIMDQYK 1382
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 64.7 bits (156), Expect = 2e-10
Identities = 84/338 (24%), Positives = 143/338 (42%), Gaps = 63/338 (18%)
Query: 330 RDSIDSCDN---DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHEL---- 382
+ S+ +C N D+ ++ + LEK + L +S + L+QEN L V L
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI---LEQENEHLNQTVSSLRQRS 574
Query: 383 ----EEMVKDQETTAEQALEEEARRHREAYGKLE-------------REKATEVELLNAR 425
E VKD E + L E + K+E +EK E L
Sbjct: 575 QISAEARVKDIEKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 426 VQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRM---MDKL 482
+ LE+EN L+ +T LK EK++ Q S+ LE + +LK +D +K + ++ L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKNLTFQLESL 692
Query: 483 RQNRLEFQKEREATQELIEDLR-------------KELEH--------LQMYKLDCERPG 521
+ + +E + +E L+ KELE L++ K ++
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 522 RGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRD---QNDDLNGQILSLSLYEAKNL 578
R + GL N R ++ LE+ K+++Q +L+D +N L + L + +K L
Sbjct: 753 RLEVSYQGLDIENQRLQKT-LENSNKKIQQLESELQDLEMENQTLQKNLEELKI-SSKRL 810
Query: 579 FAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQ 616
+ + +SL E +D+ K+ E+ N RLRQ
Sbjct: 811 EQLEKENKSLEQETSQLEKDK-----KQLEKENKRLRQ 843
Score = 60.5 bits (145), Expect = 5e-09
Identities = 72/313 (23%), Positives = 141/313 (45%), Gaps = 38/313 (12%)
Query: 325 TEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT---------------NGDLKSKLK 369
T +L S +++ E S K+ E+EN SLT N K++
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 370 QENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQL 429
+EN +L +V LE + QE + Q + ++ + +LE+ T E +++ L
Sbjct: 498 KENQRLSKKVEILENEIV-QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 430 EEENTELRTTVTRLKSQTE--------KLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDK 481
E+EN L TV+ L+ +++ +++E + + + +++TS +L +++ KR + K
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL-SKIEFEKRQIKK 615
Query: 482 LRQNRLEFQKEREATQELIEDLRKELEHLQM----YKLDCERPGRGRSASSGLGEFNARA 537
++ E + E + + L KE E LQ K+ CE+ +S L N +
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 538 REV-----ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEI 592
++ L +++ L++EN +L ++N +L + SL K AQ + ++ E
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK---MAQLQLENKELES 732
Query: 593 DTASRDELMEALK 605
+ + +E LK
Sbjct: 733 EKEQLKKGLELLK 745
Score = 53.1 bits (126), Expect = 7e-07
Identities = 74/357 (20%), Positives = 151/357 (42%), Gaps = 31/357 (8%)
Query: 245 DLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNL--KANSPNRK 302
D ++V++ + +V++ + ++V LL ++ LK L + + +
Sbjct: 151 DTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSET 210
Query: 303 ISSTAFGRQLMH-----SSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELEND 357
I + R +H SS+ S GS +S ++ + + + + ELE
Sbjct: 211 IIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEK 270
Query: 358 SLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREA-YGKLE---- 412
+ D K +L+Q +L E ++ D + E +A R + KLE
Sbjct: 271 TEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVS 330
Query: 413 --REKATEVELLNARVQQLEEENTELRTTVTRLKSQTE----------KLDEERQRMSDR 460
+E+ ++E ARV++L+E+N L T T L+ Q E +L++E ++ +
Sbjct: 331 RYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 461 LEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERP 520
L D + E D+ ++ +++L + + + ++ + + L ELE + E P
Sbjct: 391 LHDMEM----ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 521 GRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKN 577
+S + E + +R ++LE E + L + +LR D + G + E +N
Sbjct: 447 --QKSLGHEVNELTS-SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Score = 48.9 bits (115), Expect = 1e-05
Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 72/293 (24%)
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEA 401
E++ K++ +LE ++ + S+L+++ QL L + + ++TT E+
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE------ 854
Query: 402 RRHREAYGKLEREKAT---EVELLN---ARVQQLEEENTEL--------------RTTVT 441
+ G LE+E T E+ + R+++LE+EN EL R +
Sbjct: 855 --NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
Query: 442 RLKSQTEKLDEERQRMSDRLEDTSLR----LKDEM---DLYKRMMDKLR---QNRLEFQK 491
K +T++++ + ++++ LE L L DE D YK + KL + LE ++
Sbjct: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKE 972
Query: 492 EREATQELI--------EDLRKELEHLQM-YKLDCERPGRGRSASSG---LGEFNARARE 539
E+ A E + LR+EL+ ++ Y+ +R R S GE N RE
Sbjct: 973 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1032
Query: 540 VE----------------------LEHEVKRLKQENYKLRDQNDDLNGQILSL 570
+ L+ E + LK + +L QN++L QIL+L
Sbjct: 1033 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
Score = 44.3 bits (103), Expect = 3e-04
Identities = 83/379 (21%), Positives = 161/379 (42%), Gaps = 57/379 (15%)
Query: 278 CKKINLLNDLEARLKNLKANSPNRKISST--AFGRQLMHSSNFSSSNGSTEDL---FRDS 332
C+KI L +N + NRK+ T +F + N ++ R +
Sbjct: 655 CEKIEALEQ-----ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 333 IDSCDNDITEKVSF-LEKKVTELENDSLTNGD--LKSKLKQ-ENTQLVHRVHELEE--MV 386
++S + LE K E E + L G LK+ K+ E ++ ++ ++E +
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 387 KDQETTAE--QALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLK 444
K E + + Q LE E + E + ++ E+++ + R++QLE+EN L ++L+
Sbjct: 770 KTLENSNKKIQQLESELQ-DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 445 SQTEKLDEERQRMSDRLE--DTSLR---------------LKDEMDLYKRMMDKLRQNRL 487
++L++E +R+ + E DT+L L E+ +YK +L+
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK---- 884
Query: 488 EFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVK 547
E +KE +EL++ +++ L + D S L +L HE++
Sbjct: 885 ELEKE---NKELVKRATIDIKTLVTLREDL--------VSEKLKTQQMNNDLEKLTHELE 933
Query: 548 R--LKQENYKLRDQNDDLNGQILSLSLYEA--KNLFAAQTKAQSLAAEID--TASRDELM 601
+ L +E +Q+ D ++L L K+L + K +L A ++ T +L
Sbjct: 934 KIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 993
Query: 602 EALKEQEEINFRLRQYMDK 620
+ LK ++ L+Q D+
Sbjct: 994 QELKTVKKNYEALKQRQDE 1012
Score = 43.5 bits (101), Expect = 6e-04
Identities = 63/300 (21%), Positives = 127/300 (42%), Gaps = 19/300 (6%)
Query: 333 IDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETT 392
+++ +N++ ++ L+++ L+ + T +KL+ EN+ L + L Q
Sbjct: 1071 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ-NAQLLI 1129
Query: 393 AEQALEEEAR---RHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEK 449
+ +LE E + RE L + E L ++ E L + LKS +
Sbjct: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Query: 450 LDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEH 509
L+ E + + DR L+ K +++ ++M+ ++ L K E + L E +
Sbjct: 1190 LEVEHRDLEDRYNQL-LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1248
Query: 510 L-----QMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLN 564
L Q+ K ++ S L N++ + LE E +LK++ +L + LN
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKNLKSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306
Query: 565 GQILSLSLYEAKNLFAAQTKAQSLAAEIDT---ASRDELMEALKEQEEINFRLRQYMDKI 621
Q LS + + + + L +I T +R L + ++ ++ + RQY+DK+
Sbjct: 1307 NQCELLSQLKGN----LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
Score = 37.7 bits (86), Expect = 0.033
Identities = 34/140 (24%), Positives = 62/140 (44%), Gaps = 6/140 (4%)
Query: 355 ENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLERE 414
END L + S+L +E T+++ H+ + + + + LE E + +E Y +L+
Sbjct: 1245 ENDRLNH--TYSQLLKE-TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1301
Query: 415 KA---TEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDE 471
+ ELL+ LEEEN L + L Q L E+ D + D+
Sbjct: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
Query: 472 MDLYKRMMDKLRQNRLEFQK 491
++ +R +KL + ++ K
Sbjct: 1362 LNELRRQKEKLEEKIMDQYK 1381
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 63.9 bits (154), Expect = 4e-10
Identities = 90/350 (25%), Positives = 158/350 (45%), Gaps = 69/350 (19%)
Query: 337 DNDITEKVSF---LEKKVTELEN---DSLTNG-DL---KSKLKQENTQLVHRVHELEEMV 386
+ DI EK S LE+ + E + DS+ N DL + KLK+E TQL + + +++ ++
Sbjct: 1144 EQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLL 1203
Query: 387 KDQETTAEQALEEEARRHREAYGKLERE---KATEVELLNARVQQLEEENTELRTTVTRL 443
Q EEE +R+ KL+ E + + L A +Q+ EE+ +L+ +T
Sbjct: 1204 --------QLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDA 1255
Query: 444 KSQTEKLDEERQRMSDRLEDTSLRLK------------DEMDLYKRMMDKLRQNRLEFQK 491
K Q +++ +E M D ED LR+K E+D+ +R + +L++ +L QK
Sbjct: 1256 KKQIKQVQKEVSVMRD--EDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE-QLNNQK 1312
Query: 492 EREATQE-------------LIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAR 538
EA Q+ +IED+R LE + +++ + + + L E A
Sbjct: 1313 VEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVE-----QDQVLEAKLEEVERLAT 1367
Query: 539 EVELEHE-----VKRLKQENYKLRDQNDDLNGQILSL--SLYEAKNLFAAQTK-----AQ 586
E+E E + Q + K + N D+ G++ +L L E++ + A K
Sbjct: 1368 ELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKM 1427
Query: 587 SLAAEIDTAS--RDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILE 634
L + A R++ M+ E E F+ + M+ I+ A L S L+
Sbjct: 1428 MLITQAKEAENIRNKEMKKYAEDRERFFKQQNEME-ILTAQLTEKDSDLQ 1476
Score = 45.1 bits (105), Expect = 2e-04
Identities = 83/406 (20%), Positives = 173/406 (42%), Gaps = 72/406 (17%)
Query: 279 KKINLLNDLEARLKNLKANSPNRKISSTAFG--RQLMHSSNFSS---------SNGSTED 327
K + L N++E +++ N K+ T R L S S+ SNGS ED
Sbjct: 920 KIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEED 979
Query: 328 -LFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKS------KLKQENTQLVHRVH 380
L +D ND E ++ E ++ + +++ ++ + +++ H++
Sbjct: 980 NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIE 1039
Query: 381 ELEEMVKDQETTAEQALEEEAR---RHREAYGKLEREKATEVELLNARVQQLEEEN---- 433
ELE+ ++ + + +E R + + L +EK T ++ L ++L+E+N
Sbjct: 1040 ELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLK---EELQEKNVTLD 1096
Query: 434 -------------TELRTTVTRLKSQTEKLDE--ERQRM---------SDRLEDTSLRLK 469
+EL VT K++ ++L+ E Q++ D LE S+ LK
Sbjct: 1097 VQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILK 1156
Query: 470 DEMDL---YKRMMDKLRQNRLEFQKEREATQEL--IEDLRKELEHLQMYKLDCERPGRGR 524
E +L + + D ++ + KE + +E+ + + ++++HL K + E R
Sbjct: 1157 LERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQE 1216
Query: 525 SASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQI------LSLSLYEAK-- 576
+ + AR L+ +++R +++ L+++ D QI +S+ E K
Sbjct: 1217 TEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLL 1276
Query: 577 --NLFAAQTKAQSLAAEIDTASRDELMEALKEQ---EEINFRLRQY 617
+ + K + E+D R ++ LKEQ +++ ++QY
Sbjct: 1277 RIKINELEKKKNQCSQELDMKQR--TIQQLKEQLNNQKVEEAIQQY 1320
Score = 39.3 bits (90), Expect = 0.011
Identities = 82/349 (23%), Positives = 137/349 (39%), Gaps = 75/349 (21%)
Query: 327 DLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTN------GDLKSKLKQENT------- 373
DL D N+ EK++ LE K+ E T D K L QE
Sbjct: 578 DLIEDLKKKLINEKKEKLT-LEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAE 636
Query: 374 -------QLVHRVHELEEMVKD--------QETTA------EQALEEEARRHREAYGKLE 412
LV + EE KD +E TA Q E A+ E E
Sbjct: 637 RRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKE 696
Query: 413 REKATEVELLNARVQQLEEENTELRTTVTRLK------SQTEKLDEERQRMSDRLEDTSL 466
K E E ++ +Q+LE N ++ T R+K Q E E Q + +E+T
Sbjct: 697 ELKKRENES-DSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENT-F 754
Query: 467 RLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSA 526
+ D+ D +++ N+L + E ++ + E + + +L + P + +
Sbjct: 755 KCNDKADTSSLIIN----NKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGS 810
Query: 527 ---SSGLGEFNARAREV-----ELEHEVKRLKQENYKLR--------------DQNDDLN 564
SS + E ++ EV E+E +++ L++ N LR ++ +LN
Sbjct: 811 IHVSSAITEDQKKSEEVRPNIAEIE-DIRVLQENNEGLRAFLLTIENELKNEKEEKAELN 869
Query: 565 GQIL----SLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEE 609
QI+ LSL E KNL ++ + Q + + D A + ++ K QE+
Sbjct: 870 KQIVHFQQELSLSEKKNLTLSK-EVQQIQSNYDIAIAELHVQKSKNQEQ 917
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 63.2 bits (152), Expect = 7e-10
Identities = 66/253 (26%), Positives = 126/253 (49%), Gaps = 27/253 (10%)
Query: 364 LKSKLKQENTQLVHRVHELEEMVKDQETTAE-----QALEEEARRHREAYGKLEREKATE 418
L ++ KQE +L +HE E + D+ + + L E+ R +EA G+ ERE+A +
Sbjct: 715 LIARHKQEVRRL-KSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ 773
Query: 419 VELLNARVQQLEEENTELRTTVTR-LKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKR 477
+ A +++L ++ E + +TR L+++ EK EE++R +T LK +++L ++
Sbjct: 774 RQ--RAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNT---LKQQLELERQ 828
Query: 478 MMDKLRQNRLE---FQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFN 534
+ R + E +E+E +E+ + KE+E L +++L+ + + S E
Sbjct: 829 AWEAGRTRKEEAWLLNREQELREEIRKGRDKEIE-LVIHRLEADM-ALAKEESEKAAESR 886
Query: 535 ARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDT 594
+ + E E+ L+Q KL+++ +L GQ L E +NL + Q L + +
Sbjct: 887 IKRLRDKYEAELSELEQSERKLQERCSELKGQ---LGEAEGENL-----RLQGLVRQKER 938
Query: 595 ASRDELMEALKEQ 607
A D +A+ EQ
Sbjct: 939 ALED--AQAVNEQ 949
Score = 42.4 bits (98), Expect = 0.001
Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 22/194 (11%)
Query: 378 RVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELR 437
R H++E Q+ E+ E R +E L RE+ E+ R +++E L
Sbjct: 810 RRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLE 869
Query: 438 TTVTRLKSQTEKLDEER-QRMSDR-------LEDTSLRLKDEMDLYKRMM-----DKLRQ 484
+ K ++EK E R +R+ D+ LE + +L++ K + + LR
Sbjct: 870 ADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRL 929
Query: 485 NRLEFQKER--EATQELIEDLRKELEHL-QMYKLDCE-----RPGRGRSASSGLGEFNAR 536
L QKER E Q + E L E +L Q+ + + E R A + L AR
Sbjct: 930 QGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQAR 989
Query: 537 AREVELEHEVKRLK 550
+++ELE +R+K
Sbjct: 990 -QQLELEEVHRRVK 1002
Score = 31.2 bits (69), Expect = 3.0
Identities = 29/131 (22%), Positives = 60/131 (45%), Gaps = 11/131 (8%)
Query: 333 IDSCDNDITEKVSFLEKKVTELENDSLT-NGDLKSK------LKQENTQLVHRVHELEEM 385
++ + + E+ S L+ ++ E E ++L G ++ K + N QL L ++
Sbjct: 901 LEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQV 960
Query: 386 VKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQ----QLEEENTELRTTVT 441
++ + A EEE R+ + L+ + E+E ++ RV+ + EE + LRT
Sbjct: 961 IRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
Query: 442 RLKSQTEKLDE 452
+ + L+E
Sbjct: 1021 AAVKRADHLEE 1031
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 62.8 bits (151), Expect = 9e-10
Identities = 83/434 (19%), Positives = 175/434 (40%), Gaps = 64/434 (14%)
Query: 235 DDETRTNVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNL 294
++E R NV ++ VS+ Q + NS+L + SQ K++ NDL L+
Sbjct: 505 ENEKRRNVENE----VSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDL---LRTE 557
Query: 295 KANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTEL 354
+ + S T + + + + + +S D D + + LE + +
Sbjct: 558 SDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDR 617
Query: 355 ENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQE------------------------ 390
+DS GDL++++ ++ H H LE++ +++
Sbjct: 618 GHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKL 677
Query: 391 TTAEQALEEEARRHR----------------------EAYGKLEREKATEVELLNARVQQ 428
+ +Q LE+E H+ E KL+ E+ + N RV Q
Sbjct: 678 KSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAEN-RVVQ 736
Query: 429 LEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLE 488
+E++ + L + + + + E L ++RM D +++ +L+L+ E + + ++L+ E
Sbjct: 737 IEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFE 796
Query: 489 FQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKR 548
+ +++ +++ LE ++ + + + + + G + RE++ + E ++
Sbjct: 797 ADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEG------QMRELQDQLEAEQ 850
Query: 549 LKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKE-- 606
YK Q +L +I + K + Q + ++LA ++D A E L
Sbjct: 851 YFSTLYK--TQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGL 908
Query: 607 QEEINFRLRQYMDK 620
EE F L Q K
Sbjct: 909 LEEQYFELTQESKK 922
Score = 45.1 bits (105), Expect = 2e-04
Identities = 70/321 (21%), Positives = 130/321 (40%), Gaps = 74/321 (23%)
Query: 356 NDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLERE- 414
ND+ T+ + L++ L +++LEE + + E + +E++ R K+ +E
Sbjct: 412 NDNRTSSNADKSLQES---LQKTIYKLEEQLHN-EMQLKDEMEQKCRTSNIKLDKIMKEL 467
Query: 415 --KATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQR-------MSDRLED-- 463
+ + L + V Q+E+E L+ + + + E+ +E+R+ + D+LED
Sbjct: 468 DEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLK 527
Query: 464 ---------------TSLRLKDEMDLYKRMMD---KLRQNRLEFQKEREATQELIEDLRK 505
+L++ DL + D +LR++ E K + L +L++
Sbjct: 528 KVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQE 587
Query: 506 ELEHLQMYK-------------LDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQE 552
L+ K L+ ER RG S +G+ AR L+ EVK LK
Sbjct: 588 RNRILENSKSQTDKDYYQLQAILEAERRDRGHD-SEMIGDLQARI--TSLQEEVKHLKHN 644
Query: 553 ---------------NYKLRDQND---DLNGQILSL------SLYEAKNLFAAQTKAQSL 588
N+ +++N+ DLN ++ SL + E K A T
Sbjct: 645 LEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQS 704
Query: 589 AAEIDTASRDELMEALKEQEE 609
E + + E+ + LKE+ E
Sbjct: 705 IEEAKSVAMCEMEKKLKEERE 725
Score = 43.1 bits (100), Expect = 8e-04
Identities = 53/241 (21%), Positives = 98/241 (40%), Gaps = 28/241 (11%)
Query: 328 LFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVK 387
L++ + +I EK KK+ EL+N+ T TQL +L E
Sbjct: 855 LYKTQVKELKEEIEEKNRENLKKIQELQNEKETLA----------TQL-----DLAETKA 899
Query: 388 DQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQT 447
+ E A LEE+ + K E+ + V +LEE N+ L + L+ +
Sbjct: 900 ESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRREN 959
Query: 448 EKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKEL 507
E+L E +M E+ L ++E+ K +K ER + + L E+
Sbjct: 960 EELTE---KMKKAEEEYKLEKEEEISNLKAAFEK------NINTERTLKTQAVNKL-AEI 1009
Query: 508 EHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQI 567
+ + +K+D + + + E R ++EL E ++ Q K + + +D+ Q+
Sbjct: 1010 MNRKDFKIDRK---KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066
Query: 568 L 568
+
Sbjct: 1067 V 1067
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 62.4 bits (150), Expect = 1e-09
Identities = 95/409 (23%), Positives = 165/409 (40%), Gaps = 62/409 (15%)
Query: 244 SDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKI 303
S+ SV S +T K+ E ++ S K L D+EA+ +
Sbjct: 818 SEEAVSVQRSMQETVNKLHQ--KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 875
Query: 304 SSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDI----------TEKVSFLEKKVTE 353
+ + S N S D + + D+ E SFL+K + +
Sbjct: 876 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 935
Query: 354 LE-NDSLTNGDLKSKLKQENTQLVHRVHELEEMVKD-----QETTA--EQALEEEARRHR 405
+ + + K ++E +L ++ +LE+ ++ QE A E+A E +H
Sbjct: 936 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995
Query: 406 EAYGKLEREKA-TEVELLNARVQQ--LEEENTELRTTVTRLKS-QT--------EKLDEE 453
E L++ TE +L AR + L +E ELR + K+ QT E++ +E
Sbjct: 996 EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1055
Query: 454 RQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELI-------EDLRKE 506
+ LEDT K + +D L++N L+ +E ++EL+ E+ RKE
Sbjct: 1056 KTETLASLEDT----KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1111
Query: 507 LEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQE---NYKLRDQNDDL 563
+E L+ + + S L E N V+L E+ R + E + KL ++ L
Sbjct: 1112 IETLK------QAAAQKSQQLSALQEEN-----VKLAEELGRSRDEVTSHQKLEEERSVL 1160
Query: 564 NGQILSLSLYEAKNLFAAQTKAQSLAAEIDTAS-----RDELMEALKEQ 607
N Q+L + E+K + A + SL I S +D +E L+ +
Sbjct: 1161 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE 1209
Score = 59.7 bits (143), Expect = 8e-09
Identities = 72/296 (24%), Positives = 132/296 (44%), Gaps = 35/296 (11%)
Query: 342 EKVSFLEKKVTELENDSLT----NGDLKSKLKQENTQLVHRVHELEEM------------ 385
E+ L K +LEND +GD S+L + N +L + ++EE+
Sbjct: 868 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 927
Query: 386 -----VKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTV 440
++D AEQ+ +E A++H E +LER+ + L +++ + EL+
Sbjct: 928 FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD----LEKKMETSHNQCQELKARY 983
Query: 441 TRLKSQTE-KLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKER-----E 494
R S+T+ K +E Q + L DT +LK + ++ +L + R + K + E
Sbjct: 984 ERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAE 1043
Query: 495 ATQELIEDLRKE-LEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQEN 553
+++E + KE E L + + + ++ L E N + E EL + L EN
Sbjct: 1044 DAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELLTVEN 1102
Query: 554 YKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEE 609
K+ + ++ + + +++ L A Q + LA E+ SRDE+ K +EE
Sbjct: 1103 QKMEEFRKEIE-TLKQAAAQKSQQLSALQEENVKLAEELG-RSRDEVTSHQKLEEE 1156
Score = 48.5 bits (114), Expect = 2e-05
Identities = 69/315 (21%), Positives = 124/315 (39%), Gaps = 73/315 (23%)
Query: 327 DLFRDSIDSCDNDITEKVSFLE---KKVTEL----ENDSLTNGDL-------KSKLKQEN 372
D R +++ D + E ++ LE +KV +L E +S+T GDL KS++ +
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELE 470
Query: 373 TQLVHRVHELEEMVKDQETTAEQ-------ALEEEARRHREAYGKLEREKATEVELLNAR 425
L RV E+ E+ + E+ +L +E +E + E+ L
Sbjct: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEH 530
Query: 426 VQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQN 485
EE + + + L + TEKL +E + + +LE + D + L+K ++ +
Sbjct: 531 FGAREETHQK---EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIAS 587
Query: 486 RLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHE 545
Q+ +E+L+ S S GLG A E++ + E
Sbjct: 588 H----------QQAMEELKV-------------------SFSKGLGTETAEFAELKTQIE 618
Query: 546 VKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALK 605
RL + +E +NL Q ++ A+ A R +LM+ +K
Sbjct: 619 KMRLDYQ--------------------HEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 658
Query: 606 EQEEINFRLRQYMDK 620
E+E +R +DK
Sbjct: 659 EKENSLEAIRSKLDK 673
Score = 46.2 bits (108), Expect = 9e-05
Identities = 79/386 (20%), Positives = 155/386 (40%), Gaps = 37/386 (9%)
Query: 268 ELLDVYCSQCCKKI-NLLNDLEARLKNLKANSPNRKISSTAFG--RQLMHSSNFSSSNGS 324
E+L C++ K I N + L+A + L RK SS ++L +
Sbjct: 700 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIK 759
Query: 325 TEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEE 384
++ +++ S + IT ++ E K+T L+ + +K L++E L + E E
Sbjct: 760 HLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE 819
Query: 385 MVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLK 444
+ + ++ + + + E + L ++++E L + +E + E +L
Sbjct: 820 EAVSVQRSMQETVNK-LHQKEEQFNML----SSDLEKLRENLADMEAKFREKDEREEQLI 874
Query: 445 SQTEKLDE---ERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIE 501
EKL+ E +MS ++ DE+ L +R +++L+ + + Q+ IE
Sbjct: 875 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 934
Query: 502 DLRKELEHLQM--------YKLDCER-----PGRGRSASSGLGEFNARAREVELEHEVKR 548
D+ + E Q K + ER + ++ + E AR E + K
Sbjct: 935 DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 994
Query: 549 ---LKQENYKLRDQNDDLNG---------QILSLSLYEAKNLFAAQTKAQSL-AAEIDTA 595
L+ L D D L G Q L +A AAQT ++ E T
Sbjct: 995 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1054
Query: 596 SRDELMEALKEQEEINFRLRQYMDKI 621
+ E + +L++ ++ N +L+ +D +
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNELDTL 1080
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/246 (22%), Positives = 102/246 (41%), Gaps = 28/246 (11%)
Query: 351 VTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQET-TAEQALEEEARRHREAYG 409
+ LE+ TN L+++L +T + + +EE+ K +E T E EE R+ E
Sbjct: 1060 LASLEDTKQTNAKLQNEL---DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1116
Query: 410 KLEREKATEVELL---NARV--------------QQLEEENTELRTTVTRLKSQTEKL-- 450
+ +K+ ++ L N ++ Q+LEEE + L + +K + K
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1176
Query: 451 --DEERQRMSDRLEDTSLRLKD---EMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRK 505
DEE+ + + TS L + E++ + + LR + Q L D K
Sbjct: 1177 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1236
Query: 506 ELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNG 565
++ +L + R S+SSG + A E E ++ L L+ +N DL
Sbjct: 1237 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1296
Query: 566 QILSLS 571
++ +S
Sbjct: 1297 KVEMMS 1302
Score = 44.3 bits (103), Expect = 3e-04
Identities = 74/319 (23%), Positives = 124/319 (38%), Gaps = 22/319 (6%)
Query: 295 KANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTEL 354
KAN+ R +++T+ + S++ SS S S S +TE S +K++
Sbjct: 292 KANAVRRVMATTSASLKRSPSASSLSSMSSVASSV-SSRPSRTGLLTETSSRYARKIS-- 348
Query: 355 ENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLERE 414
+ LK K + L R E E+ K E +E+E R+ + + E
Sbjct: 349 -GTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE--IEQELALARDGHDQHVLE 405
Query: 415 KATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLD---EERQRMSDRLEDTSLRLKD- 470
+++ L V+ + E EL + K + E L EE LE ++ K
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
Query: 471 ----EMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSA 526
E DL R+ + R + ++ L +E+ LQ KL+ R R
Sbjct: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQ-EKLEVTRTDHQREI 524
Query: 527 SSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQ 586
+S F ARE + E+K L KL +N+ L ++ + + + ++K
Sbjct: 525 TSLKEHFG--AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK-- 580
Query: 587 SLAAEIDTASRDELMEALK 605
E AS + ME LK
Sbjct: 581 ---LETAIASHQQAMEELK 596
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/227 (20%), Positives = 93/227 (40%), Gaps = 25/227 (11%)
Query: 398 EEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRM 457
E +R R+ G ++A + + ++QL E R V + S ++++E
Sbjct: 338 ETSSRYARKISGTTALQEALKEK--QQHIEQLLAERDLERAEVAKATSHVGEIEQELALA 395
Query: 458 SDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDC 517
D + L L+ +MD + M++ + ++E + E + +EDL+ +E + K D
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
Query: 518 ERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLR---DQNDDLNGQILSLSLYE 574
E + + ++R +ELE ++ QE +LR + N +SLSL +
Sbjct: 456 E-----------VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQ 504
Query: 575 AKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+ SL +++ D E +E R + +I
Sbjct: 505 ---------EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI 542
Score = 42.0 bits (97), Expect = 0.002
Identities = 70/335 (20%), Positives = 134/335 (40%), Gaps = 50/335 (14%)
Query: 341 TEKVSFLEKKVTELENDSLT-NGDLKSKLKQENTQLVHRVHELE-------EMVKDQETT 392
TE F E K T++E L ++++ Q++++ E+E +++K++E +
Sbjct: 605 TETAEFAELK-TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 663
Query: 393 AEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLD- 451
E R K E + E+E ++Q+ E + EL + QT+ +D
Sbjct: 664 LEAI--------RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 715
Query: 452 --------EERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQ--NRLEFQKEREA------ 495
EE+ D L S K EM ++ ++ + LE +K E+
Sbjct: 716 FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSI 775
Query: 496 TQEL------IEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRL 549
T+EL + +L++ L + K E+ + A + + ++ V +L
Sbjct: 776 TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKL 835
Query: 550 KQENYKLRDQNDDLNGQILSLSLYEAK---------NLFAAQTKAQSLAAEIDTASRDEL 600
Q+ + + DL +L+ EAK L A+ K ++ AEI S D
Sbjct: 836 HQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNS 895
Query: 601 MEALKEQEEINFRLRQYMD-KIILAILDHNPSILE 634
+ K +E+ + R + ++ L + N S L+
Sbjct: 896 SQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 930
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 62.4 bits (150), Expect = 1e-09
Identities = 95/409 (23%), Positives = 165/409 (40%), Gaps = 62/409 (15%)
Query: 244 SDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKI 303
S+ SV S +T K+ E ++ S K L D+EA+ +
Sbjct: 853 SEEAVSVQRSMQETVNKLHQ--KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 910
Query: 304 SSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDI----------TEKVSFLEKKVTE 353
+ + S N S D + + D+ E SFL+K + +
Sbjct: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
Query: 354 LE-NDSLTNGDLKSKLKQENTQLVHRVHELEEMVKD-----QETTA--EQALEEEARRHR 405
+ + + K ++E +L ++ +LE+ ++ QE A E+A E +H
Sbjct: 971 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 1030
Query: 406 EAYGKLEREKA-TEVELLNARVQQ--LEEENTELRTTVTRLKS-QT--------EKLDEE 453
E L++ TE +L AR + L +E ELR + K+ QT E++ +E
Sbjct: 1031 EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1090
Query: 454 RQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELI-------EDLRKE 506
+ LEDT K + +D L++N L+ +E ++EL+ E+ RKE
Sbjct: 1091 KTETLASLEDT----KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1146
Query: 507 LEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQE---NYKLRDQNDDL 563
+E L+ + + S L E N V+L E+ R + E + KL ++ L
Sbjct: 1147 IETLK------QAAAQKSQQLSALQEEN-----VKLAEELGRSRDEVTSHQKLEEERSVL 1195
Query: 564 NGQILSLSLYEAKNLFAAQTKAQSLAAEIDTAS-----RDELMEALKEQ 607
N Q+L + E+K + A + SL I S +D +E L+ +
Sbjct: 1196 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE 1244
Score = 59.7 bits (143), Expect = 8e-09
Identities = 72/296 (24%), Positives = 132/296 (44%), Gaps = 35/296 (11%)
Query: 342 EKVSFLEKKVTELENDSLT----NGDLKSKLKQENTQLVHRVHELEEM------------ 385
E+ L K +LEND +GD S+L + N +L + ++EE+
Sbjct: 903 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 962
Query: 386 -----VKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTV 440
++D AEQ+ +E A++H E +LER+ + L +++ + EL+
Sbjct: 963 FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD----LEKKMETSHNQCQELKARY 1018
Query: 441 TRLKSQTE-KLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKER-----E 494
R S+T+ K +E Q + L DT +LK + ++ +L + R + K + E
Sbjct: 1019 ERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAE 1078
Query: 495 ATQELIEDLRKE-LEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQEN 553
+++E + KE E L + + + ++ L E N + E EL + L EN
Sbjct: 1079 DAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELLTVEN 1137
Query: 554 YKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEE 609
K+ + ++ + + +++ L A Q + LA E+ SRDE+ K +EE
Sbjct: 1138 QKMEEFRKEIE-TLKQAAAQKSQQLSALQEENVKLAEELG-RSRDEVTSHQKLEEE 1191
Score = 53.1 bits (126), Expect = 7e-07
Identities = 75/324 (23%), Positives = 135/324 (41%), Gaps = 56/324 (17%)
Query: 327 DLFRDSIDSCDNDITEKVSFLE---KKVTEL----ENDSLTNGDLKSKLKQENTQLVHRV 379
D R +++ D + E ++ LE +KV +L E +S+T GDL+++ K E+ R+
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA----RI 466
Query: 380 HELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVEL-LNARVQQLEEENTELRT 438
ELE+ + ++T A++ L+ E R A E+ + E+E L RVQ++ E L +
Sbjct: 467 KELEQSLLFEKTKADK-LQRELEDTRVATVS-EKSRIMELEKDLALRVQEVAELRRRLES 524
Query: 439 T------------VTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNR 486
+ + S EKL+ R + + +++ + L
Sbjct: 525 NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTAT 584
Query: 487 LEFQKEREATQELIEDLRKE-LEHLQMYKLDCERPGRGR---------SASSGLGEFNAR 536
+ KE E+ + +E KE + + ++K E S S GLG A
Sbjct: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 644
Query: 537 AREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTAS 596
E++ + E RL + +E +NL Q ++ A+ A
Sbjct: 645 FAELKTQIEKMRLDYQ--------------------HEIENLQNQQDSERAAHAKEMEAL 684
Query: 597 RDELMEALKEQEEINFRLRQYMDK 620
R +LM+ +KE+E +R +DK
Sbjct: 685 RAKLMKVIKEKENSLEAIRSKLDK 708
Score = 46.2 bits (108), Expect = 9e-05
Identities = 79/386 (20%), Positives = 155/386 (40%), Gaps = 37/386 (9%)
Query: 268 ELLDVYCSQCCKKI-NLLNDLEARLKNLKANSPNRKISSTAFG--RQLMHSSNFSSSNGS 324
E+L C++ K I N + L+A + L RK SS ++L +
Sbjct: 735 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIK 794
Query: 325 TEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEE 384
++ +++ S + IT ++ E K+T L+ + +K L++E L + E E
Sbjct: 795 HLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE 854
Query: 385 MVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLK 444
+ + ++ + + + E + L ++++E L + +E + E +L
Sbjct: 855 EAVSVQRSMQETVNK-LHQKEEQFNML----SSDLEKLRENLADMEAKFREKDEREEQLI 909
Query: 445 SQTEKLDE---ERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIE 501
EKL+ E +MS ++ DE+ L +R +++L+ + + Q+ IE
Sbjct: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 969
Query: 502 DLRKELEHLQM--------YKLDCER-----PGRGRSASSGLGEFNARAREVELEHEVKR 548
D+ + E Q K + ER + ++ + E AR E + K
Sbjct: 970 DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 1029
Query: 549 ---LKQENYKLRDQNDDLNG---------QILSLSLYEAKNLFAAQTKAQSL-AAEIDTA 595
L+ L D D L G Q L +A AAQT ++ E T
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1089
Query: 596 SRDELMEALKEQEEINFRLRQYMDKI 621
+ E + +L++ ++ N +L+ +D +
Sbjct: 1090 EKTETLASLEDTKQTNAKLQNELDTL 1115
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/246 (22%), Positives = 102/246 (41%), Gaps = 28/246 (11%)
Query: 351 VTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQET-TAEQALEEEARRHREAYG 409
+ LE+ TN L+++L +T + + +EE+ K +E T E EE R+ E
Sbjct: 1095 LASLEDTKQTNAKLQNEL---DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1151
Query: 410 KLEREKATEVELL---NARV--------------QQLEEENTELRTTVTRLKSQTEKL-- 450
+ +K+ ++ L N ++ Q+LEEE + L + +K + K
Sbjct: 1152 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1211
Query: 451 --DEERQRMSDRLEDTSLRLKD---EMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRK 505
DEE+ + + TS L + E++ + + LR + Q L D K
Sbjct: 1212 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1271
Query: 506 ELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNG 565
++ +L + R S+SSG + A E E ++ L L+ +N DL
Sbjct: 1272 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1331
Query: 566 QILSLS 571
++ +S
Sbjct: 1332 KVEMMS 1337
Score = 42.0 bits (97), Expect = 0.002
Identities = 70/335 (20%), Positives = 134/335 (40%), Gaps = 50/335 (14%)
Query: 341 TEKVSFLEKKVTELENDSLT-NGDLKSKLKQENTQLVHRVHELE-------EMVKDQETT 392
TE F E K T++E L ++++ Q++++ E+E +++K++E +
Sbjct: 640 TETAEFAELK-TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698
Query: 393 AEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLD- 451
E R K E + E+E ++Q+ E + EL + QT+ +D
Sbjct: 699 LEAI--------RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 750
Query: 452 --------EERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQ--NRLEFQKEREA------ 495
EE+ D L S K EM ++ ++ + LE +K E+
Sbjct: 751 FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSI 810
Query: 496 TQEL------IEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRL 549
T+EL + +L++ L + K E+ + A + + ++ V +L
Sbjct: 811 TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKL 870
Query: 550 KQENYKLRDQNDDLNGQILSLSLYEAK---------NLFAAQTKAQSLAAEIDTASRDEL 600
Q+ + + DL +L+ EAK L A+ K ++ AEI S D
Sbjct: 871 HQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNS 930
Query: 601 MEALKEQEEINFRLRQYMD-KIILAILDHNPSILE 634
+ K +E+ + R + ++ L + N S L+
Sbjct: 931 SQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
Score = 41.2 bits (95), Expect = 0.003
Identities = 78/364 (21%), Positives = 148/364 (40%), Gaps = 46/364 (12%)
Query: 295 KANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTEL 354
KAN+ R +++T+ + S++ SS S S S +TE S +K++
Sbjct: 292 KANAVRRVMATTSASLKRSPSASSLSSMSSVASSV-SSRPSRTGLLTETSSRYARKIS-- 348
Query: 355 ENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLERE 414
+ LK K + L R E E+ K E +E+E R+ + + E
Sbjct: 349 -GTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE--IEQELALARDGHDQHVLE 405
Query: 415 KATEVELLNARVQQLEEENTELRTTVTRLKSQTE----KLDEERQRMSDRLEDTSL---- 466
+++ L V+ + E EL + K + E +++EE D T L
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR 465
Query: 467 --RLKDEMDLYKRMMDKLRQ----NRLEFQKEREATQELIEDLRKELEHLQ--MYKLDCE 518
L+ + K DKL++ R+ E+ EL +DL ++ + +L+
Sbjct: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 525
Query: 519 RP-GRGRSASSGLGEFNARAREVEL-----EHEVKRLKQENYKLRDQNDDLNGQILSLSL 572
+P G + S L E ++ ++E+ + E+ LK E++ R++
Sbjct: 526 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK-EHFGAREET------------ 572
Query: 573 YEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSI 632
K + A T + L+ E + + + +L A KE ++ + + K+ AI H ++
Sbjct: 573 -HQKEIKALYTATEKLSKE-NESLKSKLEHANKENSDV---IALWKSKLETAIASHQQAM 627
Query: 633 LEIK 636
E+K
Sbjct: 628 EELK 631
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 62.0 bits (149), Expect = 2e-09
Identities = 63/252 (25%), Positives = 111/252 (44%), Gaps = 33/252 (13%)
Query: 381 ELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTV 440
E+ M +D E T E+ EARR +LE + + ++ N Q++ E L
Sbjct: 852 EMATMKEDFERTKEELARSEARRK-----ELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 441 TR--------------LKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNR 486
R +K TE+L+EE + M+ L L+D+ KR +D L
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEE-MNSELVAKKRNLEDKCSSLKRDIDDLELTL 965
Query: 487 LEFQKEREATQELIEDLRKELEHLQ--MYKLDCERPGRGRSASSGLGEFNARAREVELEH 544
+ +KE+ AT+ +++L +E+ L+ + KL E+ + L + E
Sbjct: 966 TKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE------ED 1019
Query: 545 EVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEAL 604
+V L + N KL Q DDL G SL + K L A +A+ S++ +M+
Sbjct: 1020 KVNGLIKINAKLEQQTDDLEG-----SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 605 KEQEEINFRLRQ 616
++++I +L++
Sbjct: 1075 NDKQQIEEKLKK 1086
Score = 60.1 bits (144), Expect = 6e-09
Identities = 71/342 (20%), Positives = 140/342 (40%), Gaps = 73/342 (21%)
Query: 347 LEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHRE 406
LE++ +LE L++ L++ +L + +E + D E +Q E+ ++ E
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 407 A---YGKLEREKATEVEL------LNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRM 457
K++ E+ ++ L AR+++LEEE T +++ Q L E + +
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 458 SDRLEDTSLRLKDEMDLYKR---------------------------------------M 478
S+RLE+ S ++++ K+
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 479 MDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNAR-A 537
+D L++ + + +KE+ + I+D+ +E L K + ER R+ E A+
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIER--TCRTVEDQFSEIKAKDE 1268
Query: 538 REVELEHEVKRLKQENYKLRDQNDDL----------------NGQILSLSLYEAKNLFAA 581
++ +L H+ L + +L+ QN +L + Q L+ L E K
Sbjct: 1269 QQTQLIHD---LNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE 1325
Query: 582 QTKAQSLAAEIDTASR---DELMEALKEQEEINFRLRQYMDK 620
+TKA++ A +SR D L E +E++E L++ + K
Sbjct: 1326 ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367
Score = 50.1 bits (118), Expect = 6e-06
Identities = 66/306 (21%), Positives = 134/306 (43%), Gaps = 39/306 (12%)
Query: 330 RDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQ 389
R+ D C + + + LE +T++E + + L +E T L + +L + K
Sbjct: 945 RNLEDKCSS-LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSL 1003
Query: 390 ETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQ----LE---EENTELRTTVTR 442
+ +Q L++ ++E +K + +NA+++Q LE E+ +LR + R
Sbjct: 1004 QEAHQQTLDDL---------QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054
Query: 443 LKSQTE---KLDEER----QRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREA 495
K + E K+ +E + ++E+ + + E+ + +D + + L+FQK+ +
Sbjct: 1055 AKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKE 1114
Query: 496 TQELIEDLRKEL--EHLQMYKLDCERPGRGRSASSGLGEFNARAREVE--LEHEVKRLKQ 551
Q IE+L +E+ EH K++ +R R L E + R E +++ K+
Sbjct: 1115 LQARIEELEEEIEAEHTLRAKIEKQRSDLARE----LEEISERLEEASGATSAQIEMNKK 1170
Query: 552 ENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLA---AEIDTASRDELMEALKEQE 608
+ + DL L +EA + +A S+A +ID R + + KE+
Sbjct: 1171 REAEFQKMRRDLEEATLQ---HEATAATLRKKQADSVAELGEQIDNLQRVK-QKLEKEKS 1226
Query: 609 EINFRL 614
E+ +
Sbjct: 1227 ELKMEI 1232
Score = 49.7 bits (117), Expect = 8e-06
Identities = 76/346 (21%), Positives = 141/346 (40%), Gaps = 46/346 (13%)
Query: 311 QLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQ 370
QL+H N + T++ + + EK S + + + + +LK ++++
Sbjct: 1272 QLIHDLNMQKARLQTQN------GELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE 1325
Query: 371 ENTQLVHRVHELEEMVKDQETTAEQALEEEARRH--REAYGKLEREKAT-----EVELLN 423
E H L+ D + EQ EE+ + + A K E A E + +
Sbjct: 1326 ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQ 1385
Query: 424 ARVQQLEEENTELRTTVTRLKSQTE-------KLDEERQRMSDRLEDTSLRLKDEMDLYK 476
R ++LEE +L + + TE L++ +QR+ +ED +R +
Sbjct: 1386 -RTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL-MRDLERSHTAC 1443
Query: 477 RMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNAR 536
+DK ++N F K ++ +++ + ELE Q RS S+ L F R
Sbjct: 1444 ATLDKKQRN---FDKVLAEWKQKLDESQAELEAAQK---------ESRSLSTEL--FKMR 1489
Query: 537 AREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQ-TKAQSLAAEIDTA 595
E+ +++ L++EN L+++ DL QI KNL A+ TK + D
Sbjct: 1490 NAYEEVVDQLETLRRENKNLQEEISDLTEQIAE----TGKNLQEAEKTKKLVEQEKSDLQ 1545
Query: 596 SRDELMEALKEQEE-----INFRLRQYMDKIILAILDHNPSILEIK 636
E +E E EE + L Q ++ +++ + I ++K
Sbjct: 1546 VALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLK 1591
Score = 41.6 bits (96), Expect = 0.002
Identities = 57/274 (20%), Positives = 116/274 (42%), Gaps = 36/274 (13%)
Query: 347 LEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHRE 406
L+ L++ +N DLK +L + + ELEEM + ALE+ R R
Sbjct: 1654 LKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM--------KVALEQTERTRR- 1704
Query: 407 AYGKLEREKATEVELLNA--RVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDT 464
+E ELL+A RVQ L +NT L T +L++ + E + +
Sbjct: 1705 ---------LSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNA 1755
Query: 465 SLRLKDEMDLYKRMMDKLRQNR---LEFQKEREATQELIEDLRKELEHLQMYKLDCERPG 521
+ K + M ++L++ + ++ ++ ++ ++DL+ L+ + L
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL------ 1809
Query: 522 RGRSASSGLGEFNARAREVELEHEVKRLK-QENYKLRDQNDDLNGQILSLSLYEAKNLFA 580
+ + + R RE+E E +V++ + E K + + ++ + + KN+
Sbjct: 1810 --KGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILR 1867
Query: 581 AQTKAQSLAAEIDTASRDELMEALKEQEEINFRL 614
Q L A++ + R +A + +E+ N +L
Sbjct: 1868 LQDLVDKLQAKVKSYKR----QAEEAEEQANTQL 1897
Score = 31.2 bits (69), Expect = 3.0
Identities = 35/171 (20%), Positives = 73/171 (42%), Gaps = 9/171 (5%)
Query: 458 SDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDC 517
S E +K++ + K + + R E +++ + + DL+ +++ +D
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 518 ERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQND-------DLNGQILSL 570
E G S L E + LE E + + K R+ D D++ L+L
Sbjct: 906 EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965
Query: 571 SLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+ E K A + K ++L+ E+ TA + + + KE++ + +Q +D +
Sbjct: 966 TKVE-KEKHATENKVKNLSEEM-TALEENISKLTKEKKSLQEAHQQTLDDL 1014
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 62.0 bits (149), Expect = 2e-09
Identities = 94/399 (23%), Positives = 172/399 (43%), Gaps = 35/399 (8%)
Query: 244 SDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKI 303
S++ V+S + Q K + N E +D SQ + +NDL+ RLK +N +
Sbjct: 909 SNMEVQVASQSSQRTGKGQPS-NKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967
Query: 304 SSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGD 363
T+ L + TE++ R +I+ + E + LEKK+ E+E + D
Sbjct: 968 MVTSLEESL------NKEKQVTEEV-RKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD 1020
Query: 364 LKSK----LKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHR----------EAYG 409
K + ++Q+ ++L + ++ V++ A AL E + R EA
Sbjct: 1021 DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN 1080
Query: 410 KLERE---KATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSL 466
K ERE A +VE L A +Q+ +++ + L+ T+K + + E+
Sbjct: 1081 KYERELMLHAADVEALQAAKEQV----SKMASVRQHLEETTQKAESQLLECKASWEERER 1136
Query: 467 RLKDEMD-LYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRS 525
LKDE+ R D +QNRL + + + +++ +++ ++ L E G+ +
Sbjct: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEE--GKSQE 1194
Query: 526 ASSGLGEFNARAREV-ELEHEVKRLKQENYKLRDQNDDLNGQIL--SLSLYEAKNLFAAQ 582
+ F R +E+ E EV +++ Y+ R + + Q L SL+ K A+
Sbjct: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
Query: 583 TKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
T AQ T + + +ME K E RL Q + ++
Sbjct: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293
Score = 62.0 bits (149), Expect = 2e-09
Identities = 87/383 (22%), Positives = 159/383 (41%), Gaps = 58/383 (15%)
Query: 287 LEARLKNLK--ANSPNRKISSTAFG----RQLMHSSNFSSSNGSTEDLFRDSIDSCDNDI 340
LE L+ L+ N+ K+ TA +LM + + T + R+ + + D+
Sbjct: 1231 LERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDL 1290
Query: 341 TEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEE 400
+ ++ KV +LE D L + ++L +++ L LEE VK + + + ++
Sbjct: 1291 QQ----MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
Query: 401 ARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRL----------------- 443
E Y KL EK E+ R+QQL EE L+ + R
Sbjct: 1347 KDPDTEEYRKLLSEK----EVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED 1402
Query: 444 --KSQTEK------LD------EERQRMSDRLEDTSLRLKDEMDLYKRMMDKL----RQN 485
K +TEK LD +E+ + +++ R K + + K DK+ Q+
Sbjct: 1403 LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQS 1462
Query: 486 RLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNAR---AREVEL 542
+ Q++ + QE+ ++L++ L + E + E AR + V+L
Sbjct: 1463 SGDHQEQHVSVQEM-QELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQL 1521
Query: 543 EHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELME 602
+ E+ RL+Q+ Q + L QI K + AA++K LA +D+L +
Sbjct: 1522 QSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLA-----GVKDQLTK 1576
Query: 603 ALKEQEEINFRLRQYMDKIILAI 625
+E ++ N L Q D++ + I
Sbjct: 1577 ENEELKQRNGALDQQKDELDVRI 1599
Score = 48.1 bits (113), Expect = 2e-05
Identities = 85/382 (22%), Positives = 160/382 (41%), Gaps = 60/382 (15%)
Query: 288 EARLKNLKANSPNRKISSTAFGRQL------MHSSNFSSSNGST--------EDLFRDSI 333
E R +NLK K+S +Q N +N T E + +
Sbjct: 778 EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL 837
Query: 334 DSCDNDITEKVSFLEKKV-TELEN-DSLTNG------DLKSKLKQENTQLVHRVHELEEM 385
S + ++S L+KK+ E+E +LT D K +L E T L EL +
Sbjct: 838 SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE-TNLHLNTKELLKN 896
Query: 386 VKDQETTAEQALE----EEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVT 441
+ + T +Q L + A + + GK + +V+ L ++++Q EE+ +L+
Sbjct: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE--- 953
Query: 442 RLKSQT--------------EKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRL 487
RLK+ T E L++E+Q + ++ +RLK+ + ++ KL +
Sbjct: 954 RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL----M 1009
Query: 488 EFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARA-REVELEHEV 546
E +KE+ QEL +D R+ +E ++ + ++ S + + E RA + E +
Sbjct: 1010 EVEKEK---QELQDDKRRAIESMEQQLSELKK--TLSSVQNEVQEALQRASTALSNEQQA 1064
Query: 547 KRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAA------EIDTASRDEL 600
+R QE K+ + + + L L + + L AA+ + +A+ E + +L
Sbjct: 1065 RRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQL 1124
Query: 601 MEALKEQEEINFRLRQYMDKII 622
+E EE L+ + K +
Sbjct: 1125 LECKASWEERERMLKDEVSKCV 1146
Score = 45.8 bits (107), Expect = 1e-04
Identities = 79/427 (18%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 244 SDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKI 303
SD+ + +++ H N+ L ++ + + L + + LK N N+K
Sbjct: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
Query: 304 SSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELE-------- 355
+ Q+ + +SN + D + ++ S EK EL
Sbjct: 232 EVSRLEEQM---NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNL 288
Query: 356 -----NDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGK 410
+DS + ++ +E +L+ E + ++D EQ+ ++ + E G+
Sbjct: 289 YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR 348
Query: 411 LEREKATEVELLNARVQQ----LEEENTELRTT---VTRLKSQTEKLDE--------ERQ 455
LE+E +LL+A ++ EEE + T V ++ KL E + Q
Sbjct: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
Query: 456 RMSDRLEDTSLRLKDEMDLYKRMMDK---LRQNRLEFQKEREATQELIEDLRKELEHLQM 512
+ ++LE+ + K ++ K + K L++ R E+++ ++A L L + ++ +Q
Sbjct: 409 LLLEKLENKRIN-KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQR 467
Query: 513 YKLDCERPGRGRSASSGLGEFNARAREV---ELEHEVKRLKQE------NYKLRDQ---- 559
+ D ++ + S + E + R E+ +L +++ L E N+ +RD+
Sbjct: 468 LQEDTDKANK----QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 560 -NDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEI----DTASRDELMEALKEQEEINFRL 614
+ + +++S L +N+ Q + Q L + +T R+E + E+ +L
Sbjct: 524 ADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583
Query: 615 RQYMDKI 621
+ ++
Sbjct: 584 ESALTEL 590
Score = 45.4 bits (106), Expect = 2e-04
Identities = 63/325 (19%), Positives = 139/325 (42%), Gaps = 31/325 (9%)
Query: 308 FGRQLM-HSSNFSSSNGSTEDLFR-DSIDSCDNDITEKVS--FLEKKVTELENDSLTNGD 363
+ R+LM H+++ + + E + + S+ + T+K LE K + E + + +
Sbjct: 1082 YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDE 1141
Query: 364 LKS------KLKQENTQLVHRVHELEEMVKDQETTAEQ-----ALEEEARRHREAYGKLE 412
+ L+++N L ++ +L + V Q +L EE + + ++
Sbjct: 1142 VSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL-EIL 1200
Query: 413 REKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEM 472
R E E+ R + + E+ R V L+ + ++L + ++++ T+ +
Sbjct: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE 1260
Query: 473 DLYKRM--MDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGL 530
+L K+ M+ + + ++E+E ++ ++ ++ ++ L++ L + S SG+
Sbjct: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM 1320
Query: 531 GEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQ----ILSLSLYEAKNLFAAQTKAQ 586
+A + LE +VKR K N L Q D + + +LS K + +
Sbjct: 1321 ----LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376
Query: 587 SLAAEI-----DTASRDELMEALKE 606
L AEI + L+++LKE
Sbjct: 1377 RLKAEIARSNASLTNNQNLIQSLKE 1401
Score = 44.3 bits (103), Expect = 3e-04
Identities = 42/228 (18%), Positives = 100/228 (43%), Gaps = 38/228 (16%)
Query: 395 QALEEEA--RRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDE 452
+A+E +A ++ +E + ++EKA ++ N ++++L+E+ T+LR+ T++ +Q + +
Sbjct: 664 EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASK 723
Query: 453 ERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQM 512
+ + D +E Y+R + L + + + +++I + ++L
Sbjct: 724 RYEMLQDNVEG-----------YRREITSLHERNQKLTATTQKQEQIINTMTQDL----- 767
Query: 513 YKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSL 572
R A+ L RA ++ E E+ LK +L Q + L L+
Sbjct: 768 -----------RGANEKLAVAEVRAENLKKEKEM--LKLSEVRLSQQRESL------LAE 808
Query: 573 YEAKNLFAAQTKA-QSLAAEIDTASRDELMEALKEQEEINFRLRQYMD 619
+NL + Q + +T ++ L +++ E L++ ++
Sbjct: 809 QRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE 856
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/251 (19%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 340 ITEKVSFLEKKVTELENDSLTNGD-----LKSKLKQENTQLVHRVHELEEMVKD--QETT 392
+TE++ L+ ++ N SLTN LK L + T+ +L+ + D ++
Sbjct: 1371 LTEEIGRLKAEIAR-SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVK 1429
Query: 393 AEQALEEEARRHREAYGKL--EREKATEVELLNARVQQLE----EENTELRTTVTRLKSQ 446
+++ RR++ Y +L +++K E ++ Q + +E EL+ T+ + +++
Sbjct: 1430 TITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETK 1489
Query: 447 TEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKE 506
++ L+ + + + L + ++ L++ ++ Q E ++ ++D +
Sbjct: 1490 SKSLESQVENLQKTLSEKETEARN-----------LQEQTVQLQSELSRLRQDLQDRTTQ 1538
Query: 507 LEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQ 566
E L+ + E R ++ + + +L E + LKQ N L Q D+L+ +
Sbjct: 1539 EEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVR 1598
Query: 567 ILSL-SLYEAK 576
I +L S YE +
Sbjct: 1599 ITALKSQYEGR 1609
Score = 43.5 bits (101), Expect = 6e-04
Identities = 54/241 (22%), Positives = 104/241 (43%), Gaps = 26/241 (10%)
Query: 380 HELEEMVKDQETTAEQALEEEAR---RHREAYGKLEREKATEVELLNARVQQLEEENTEL 436
++LE+ + DQ++ + + + Y ++E+ + E L ++ + EL
Sbjct: 23 NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLEL 82
Query: 437 RTTVTRLKSQTEKLDEERQRMSDR---LEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKER 493
+LK+ TEK ++E + DR ++ R K+E++ KR D +R N +E
Sbjct: 83 EKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKR--DLIRTNE-RLSQEL 138
Query: 494 EATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQEN 553
E E ++ L ++L+ K + + L +A +V +++ KRL+QE
Sbjct: 139 EYLTEDVKRLNEKLKESNTTKGELQ-----------LKLDELQASDVSVKYREKRLEQEK 187
Query: 554 YKLRDQNDDLNGQILS-----LSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQE 608
L QN LN ++ + L+L K + K + + + +E M LK
Sbjct: 188 ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN 247
Query: 609 E 609
E
Sbjct: 248 E 248
Score = 39.3 bits (90), Expect = 0.011
Identities = 35/161 (21%), Positives = 65/161 (40%), Gaps = 11/161 (6%)
Query: 338 NDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQAL 397
N K LE +V L+ L+++ QL + L + ++D+ T EQ
Sbjct: 1484 NQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLR 1543
Query: 398 EEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRM 457
++ + + + K+ L + QL +EN EL+ L Q ++LD +
Sbjct: 1544 QQITEKEEKTRKAIVAAKSKIAHLAGVK-DQLTKENEELKQRNGALDQQKDELDVRITAL 1602
Query: 458 SDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQE 498
+ E RL+ E LR+++ ++R+ QE
Sbjct: 1603 KSQYEGRISRLERE----------LREHQERHLEQRDEPQE 1633
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/370 (21%), Positives = 162/370 (43%), Gaps = 36/370 (9%)
Query: 270 LDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHS-SNFSSSNGSTEDL 328
L+ CS+ K I+ L A+++ K + N+ + T L + + S + ++
Sbjct: 946 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQET 1005
Query: 329 FRDSIDSCD------NDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHEL 382
+ ++D N +T+ + LE++V +LE L+ L++ +L +
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1065
Query: 383 EEMVKDQETTAEQALEEEARRHREA---YGKLEREKATEVEL------LNARVQQLEEEN 433
+E D E +Q E+ ++ E K+E E+A E++L L AR+++L EE
Sbjct: 1066 QESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEI 1125
Query: 434 TELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRM---MDKLRQNRLEFQ 490
R + + + Q L E + +S+RLE+ +++L K+ KLR++ E
Sbjct: 1126 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEAT 1185
Query: 491 KEREAT--------QELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARA---RE 539
+ EA + + +L +++++LQ K E+ + NA A +
Sbjct: 1186 LQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAK 1245
Query: 540 VELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDE 599
LE + L+ + +L+ + ++ I L+ A+ QT+A + ++D +D
Sbjct: 1246 GNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR----LQTEAGEYSRQLD--EKDA 1299
Query: 600 LMEALKEQEE 609
L+ L ++
Sbjct: 1300 LVSQLSRSKQ 1309
Score = 54.7 bits (130), Expect = 3e-07
Identities = 63/304 (20%), Positives = 137/304 (45%), Gaps = 46/304 (15%)
Query: 339 DITEKVSFLEKKVTEL------ENDSLTNGDLK-SKLKQENTQLVHRVHELEEMVKDQE- 390
++ EK+ L K+ +L E DSL + + + +L + QL ++ E+ E +++E
Sbjct: 875 ELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEE 934
Query: 391 -----TTAEQALEEEARRHRE-------AYGKLEREK-ATEVELLNARVQQLEEENTELR 437
T ++ LE+E ++ K+E+EK ATE +V+ L EE L
Sbjct: 935 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE-----NKVKNLTEEMAGLD 989
Query: 438 TTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQ 497
T+ +L + + L E Q+ D L+ +D++++ + KL Q
Sbjct: 990 ETIAKLSKEKKALQETHQQTLDDLQAE----EDKVNILTKAKTKLEQQ------------ 1033
Query: 498 ELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLR 557
++DL LE + ++D ER R L + + E + + ++L+++ +++
Sbjct: 1034 --VDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEIS 1091
Query: 558 DQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQY 617
+ + + ++ + K + Q + + L EI+ A R +A K++ +++ L +
Sbjct: 1092 NLISKIEDE-QAVEIQLQKKIKELQARIEELGEEIE-AERASRAKAEKQRSDLSRELEEI 1149
Query: 618 MDKI 621
+++
Sbjct: 1150 SERL 1153
Score = 53.9 bits (128), Expect = 4e-07
Identities = 65/278 (23%), Positives = 121/278 (43%), Gaps = 39/278 (14%)
Query: 364 LKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHR---------EAYGKLERE 414
+K LK T+ E+ M ++ + T ++ + EA+R + L+ +
Sbjct: 839 IKPLLKSAETE-----KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ 893
Query: 415 KATEVELL---NARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDE 471
+E + L R +QL + +L ++K TE+ +EE + ++ L +L+DE
Sbjct: 894 VQSEADSLADAEERCEQLIKNKIQLEA---KIKEVTERAEEEEE-INAELTAKKRKLEDE 949
Query: 472 MDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQ--MYKLDCERPGRGRSASSG 529
K+ +D L + +KE+ AT+ +++L +E+ L + KL E+ +
Sbjct: 950 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQT 1009
Query: 530 LGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQI-----LSLSLYEAKNLFAAQTK 584
L + A E +V L + KL Q DDL G + L + L AK K
Sbjct: 1010 LDDLQAE------EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1063
Query: 585 -AQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
AQ +++ + +L E L+++E F + + KI
Sbjct: 1064 LAQESTMDMEN-DKQQLDEKLEKKE---FEISNLISKI 1097
Score = 51.2 bits (121), Expect = 3e-06
Identities = 118/592 (19%), Positives = 227/592 (38%), Gaps = 93/592 (15%)
Query: 80 AMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPTFADGELIPREPGFFPEDEE 139
A + CE+L+K+ + +E+ E+ + E+ E+ A + E +D +
Sbjct: 904 AEERCEQLIKNKIQLEAK-----IKEVTERAEEEEEINAELTAKKRKLEDECSELKKDID 958
Query: 140 EA-MTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLGGLFLPEDKSLVHTPSMTT 198
+ +TLA E + + T+ + G + A+ E K+L T T
Sbjct: 959 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLS--------KEKKALQETHQQTL 1010
Query: 199 SDLSTHS------TTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRTNVYSDLGSSVSS 252
DL T + E+Q +D EG ++ + + + DL + S
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDL-EGS-LEQEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 253 SAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQL 312
+ K + E + S KI +E +L+ K +I G ++
Sbjct: 1069 TMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQK-KIKELQARIEE--LGEEI 1125
Query: 313 MHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQEN 372
E R + +D++ ++ + +++ E + +L K + E
Sbjct: 1126 -----------EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEF 1174
Query: 373 TQLVHRVHEL----EEMV-----KDQETTAEQALEEEARRHREAYGKLEREKAT---EVE 420
+L + E E MV K ++ AE L E+ + KLE+EK+ E +
Sbjct: 1175 QKLRRDLEEATLQHEAMVAALRKKHADSMAE--LGEQIDNLQRVKQKLEKEKSELKMETD 1232
Query: 421 LLNARVQQLEEENTELRTTVTRLKSQTEKL---DEERQRMSDRLEDTSLRLKDEMDLYKR 477
L++ + + + L L+ Q +L +EE+QR+ + L RL+ E Y R
Sbjct: 1233 DLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSR 1292
Query: 478 MMDKLRQNRLEFQKEREATQELIEDLRKELEH-----------LQMYKLDC--------- 517
+D+ + + ++A+ + IE+L+ +LE LQ + DC
Sbjct: 1293 QLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE 1352
Query: 518 ERPGRGR------SASSGLG------EFNARAREVELEHEVKRLKQENYKLRDQNDDLNG 565
E+ G+ A+S + E +A R ELE K+L Q + + + +N
Sbjct: 1353 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNA 1412
Query: 566 QILSLS------LYEAKNLFAAQTKAQSLAAEIDTASR--DELMEALKEQEE 609
+ SL E ++L ++ + A +D R D+++ K++ E
Sbjct: 1413 KCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464
Score = 49.7 bits (117), Expect = 8e-06
Identities = 59/252 (23%), Positives = 111/252 (44%), Gaps = 22/252 (8%)
Query: 279 KKINLLN-DLEARLKNLKANSPNRKISSTAF-----GRQLMHSSNFSSSNGSTEDLFRDS 332
++ NLL ++E L+ +RKI+ QL+H+ N S N T+ +
Sbjct: 1679 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN--TKKKLEND 1736
Query: 333 IDSCDNDITEKVSF---LEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQ 389
+ +++ E + E+K + D+ + K + + L LE+ VKD
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1796
Query: 390 ETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTE----LRTTVTRLKS 445
+ ++A + + ++ KLE V L V+ ++ N E LR R+K
Sbjct: 1797 QHRLDEAEQLALKGGKKQIQKLE----ARVRELEGEVENEQKRNAEAVKGLRKHERRVKE 1852
Query: 446 QTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKL-RQNRLEFQKEREATQELIE-DL 503
T + +E+R+ + RL+D +L+ ++ YKR ++ Q+ K R+ EL E +
Sbjct: 1853 LTYQTEEDRKNVL-RLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911
Query: 504 RKELEHLQMYKL 515
R ++ Q+ KL
Sbjct: 1912 RADIAESQVNKL 1923
Score = 49.3 bits (116), Expect = 1e-05
Identities = 64/281 (22%), Positives = 120/281 (42%), Gaps = 41/281 (14%)
Query: 354 LENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRH------REA 407
L N T G LK TQL L++ ++ QE EQ E R + E
Sbjct: 1643 LRNYRNTQGILKE------TQL-----HLDDALRGQEDLKEQLAIVERRANLLQAEIEEL 1691
Query: 408 YGKLER----EKATEVELLNA--RVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRL 461
+ LE+ K E ELL+A RVQ L +NT L T +L++ +L E + +
Sbjct: 1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQES 1751
Query: 462 EDTSLRLKDEMDLYKRMMDKLRQNR---LEFQKEREATQELIEDLRKELEHLQMYKLDCE 518
+ + K + M ++L++ + ++ ++ ++ ++DL+ L+ + L
Sbjct: 1752 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL--- 1808
Query: 519 RPGRGRSASSGLGEFNARAREV--ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAK 576
+ + + AR RE+ E+E+E KR + LR + ++ + + K
Sbjct: 1809 -----KGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVK-ELTYQTEEDRK 1862
Query: 577 NLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQY 617
N+ Q L A++ + R +A + +E+ N L ++
Sbjct: 1863 NVLRLQDLVDKLQAKVKSYKR----QAEEAEEQSNANLSKF 1899
Score = 38.9 bits (89), Expect = 0.015
Identities = 61/315 (19%), Positives = 125/315 (39%), Gaps = 33/315 (10%)
Query: 335 SCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQL------VHRVHELEEMVKD 388
S ++ + + E+ + +LE N +L+ ++ Q+ +H + ++++ V+
Sbjct: 1479 SLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ 1538
Query: 389 QETTAEQALEEEARRHREAYGKLEREKATEVEL------LNARVQQLEEENTELRTTVTR 442
++ + ALEE GK+ R ++EL ++ ++ + +EE +L+ TR
Sbjct: 1539 EKCEIQAALEEAEASLEHEEGKILR---IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTR 1595
Query: 443 -LKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIE 501
+++ LD E + +D L ++ K E DL + + NRL + R
Sbjct: 1596 VVETMQSTLDAEIRSRNDALR---VKKKMEGDLNEMEIQLNHANRLAAESLRN-----YR 1647
Query: 502 DLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQND 561
+ + L+ Q++ D R + E A + E+E L+Q +
Sbjct: 1648 NTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQ 1707
Query: 562 DLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+L + L +N TK + +++ + E EE+ R +K
Sbjct: 1708 ELLDASERVQLLHTQNTSLINTKKK---------LENDVSQLQSEVEEVIQESRNAEEKA 1758
Query: 622 ILAILDHNPSILEIK 636
AI D E+K
Sbjct: 1759 KKAITDAAMMAEELK 1773
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 61.2 bits (147), Expect = 3e-09
Identities = 76/346 (21%), Positives = 143/346 (41%), Gaps = 63/346 (18%)
Query: 338 NDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQAL 397
N +T+ LE++V +LE ++ L++ +L + +E D E +Q
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081
Query: 398 EEEARRHREAYG---KLEREKATEVEL------LNARVQQLEEENTELRTTVTRLKSQTE 448
E+ ++ E G K+E E+A ++L L AR+++LEEE R + + + Q
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1141
Query: 449 KLDEERQRMSDRLEDTSLRLKDEMDLYKRM---MDKLRQNRLEFQKEREAT--------Q 497
L E + +S+RLE+ ++++ K+ K+R++ E + EAT
Sbjct: 1142 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1201
Query: 498 ELIEDLRKELEHLQMYKLDCER------------PGRGRSASSGLGEFNARAREVELE-H 544
+ + +L +++++LQ K E+ + S G R +E +
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261
Query: 545 EVKRLKQENYKL---------------------RDQNDDLNGQI------LSLSLYEAKN 577
E+K ++E +L D+ D L Q+ + + E K
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKR 1321
Query: 578 LFAAQTKAQSLAAEIDTASR---DELMEALKEQEEINFRLRQYMDK 620
+ KA+S A +SR D L E +E++E L++ M K
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367
Score = 56.6 bits (135), Expect = 7e-08
Identities = 65/261 (24%), Positives = 115/261 (44%), Gaps = 28/261 (10%)
Query: 364 LKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHR--EAYGKLEREKATEVEL 421
+K LK T+ E+ M ++ E T E+ + EA+R E L +EK
Sbjct: 840 IKPLLKSAETE-----KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 422 LNARVQQL---EEENTELRTTVTRLKSQTEKLDE---ERQRMSDRLEDTSLRLKDEMDLY 475
+ A L EE +L T +L+++ +++ E + + ++ L +L+DE
Sbjct: 895 VQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 476 KRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQ--MYKLDCERPGRGRSASSGLGEF 533
K+ +D L + +KE+ AT+ +++L +E+ L + KL E+ + L +
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014
Query: 534 NARAREVELEHEVKRLKQENYKLRDQNDDLNGQI-----LSLSLYEAKNLFAAQTK-AQS 587
A E +V L + KL Q DDL G + + + L AK K AQ
Sbjct: 1015 QAE------EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 588 LAAEIDTASRDELMEALKEQE 608
+I+ + +L E LK++E
Sbjct: 1069 STMDIEN-DKQQLDEKLKKKE 1088
Score = 50.1 bits (118), Expect = 6e-06
Identities = 61/304 (20%), Positives = 130/304 (42%), Gaps = 46/304 (15%)
Query: 339 DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHR-------VHELEEMVKDQE- 390
++ EK+ L ++ +L+ D + ++ QL+ + E+ E +D+E
Sbjct: 876 ELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE 935
Query: 391 -----TTAEQALEEEARRHRE-------AYGKLEREK-ATEVELLNARVQQLEEENTELR 437
T ++ LE+E ++ K+E+EK ATE +V+ L EE L
Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE-----NKVKNLTEEMAGLD 990
Query: 438 TTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQ 497
T+ +L + + L E Q+ D L+ +D+++ + KL Q
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAE----EDKVNTLTKAKIKLEQQ------------ 1034
Query: 498 ELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLR 557
++DL LE + ++D ER R L + + E + + ++LK++ +++
Sbjct: 1035 --VDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMS 1092
Query: 558 DQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQY 617
+ + +L + K + Q + + L EI+ A R +A K++ +++ L +
Sbjct: 1093 GLQSKIEDE-QALGMQLQKKIKELQARIEELEEEIE-AERASRAKAEKQRSDLSRELEEI 1150
Query: 618 MDKI 621
+++
Sbjct: 1151 SERL 1154
Score = 48.5 bits (114), Expect = 2e-05
Identities = 57/259 (22%), Positives = 111/259 (42%), Gaps = 30/259 (11%)
Query: 372 NTQLVHRVHEL--EEMVKDQETTAEQA---------LEEEARRHREAYGKLERE-KATEV 419
NTQ + + +L ++ ++ QE EQ L+ E R + ER K E
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1708
Query: 420 ELLNA--RVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKR 477
ELL+A RVQ L +NT L T +L++ ++ E + + + + K +
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM 1768
Query: 478 MMDKLRQNR---LEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFN 534
M ++L++ + ++ ++ ++ ++DL+ L+ + L + + +
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL--------KGGKKQIQKLE 1820
Query: 535 ARAREV--ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEI 592
AR RE+ E+E E KR + LR + ++ + + KN+ Q L A++
Sbjct: 1821 ARVRELEGEVESEQKRNVEAVKGLRKHERKVK-ELTYQTEEDRKNILRLQDLVDKLQAKV 1879
Query: 593 DTASRDELMEALKEQEEIN 611
+ R E +EQ +N
Sbjct: 1880 KSYKRQ--AEEAEEQSNVN 1896
Score = 48.5 bits (114), Expect = 2e-05
Identities = 59/250 (23%), Positives = 109/250 (43%), Gaps = 18/250 (7%)
Query: 279 KKINLLN-DLEARLKNLKANSPNRKISSTAF-----GRQLMHSSNFSSSNGSTE-DLFRD 331
++ NLL ++E L+ +RKI+ QL+H+ N S N + +
Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739
Query: 332 SIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQET 391
I DI ++ E+K + D+ + K + + L LE+ VKD +
Sbjct: 1740 QIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1799
Query: 392 TAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTE----LRTTVTRLKSQT 447
++A + + ++ KLE V L V+ ++ N E LR ++K T
Sbjct: 1800 RLDEAEQLALKGGKKQIQKLE----ARVRELEGEVESEQKRNVEAVKGLRKHERKVKELT 1855
Query: 448 EKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKL-RQNRLEFQKEREATQELIE-DLRK 505
+ +E+R+ + RL+D +L+ ++ YKR ++ Q+ + K R EL E + R
Sbjct: 1856 YQTEEDRKNIL-RLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERA 1914
Query: 506 ELEHLQMYKL 515
++ Q+ KL
Sbjct: 1915 DIAESQVNKL 1924
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/295 (20%), Positives = 122/295 (41%), Gaps = 41/295 (13%)
Query: 338 NDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQE------- 390
+D+TE+++ K++ ELE +K +++QE ++L + E E ++ +E
Sbjct: 1514 SDLTEQIAEGGKRIHELEK-------IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566
Query: 391 TTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTE-K 449
Q E R+ E ++++ K + ++ + L+ E R RLK + E
Sbjct: 1567 LELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAE-IRSRNDAIRLKKKMEGD 1625
Query: 450 LDEERQRMSDR-----------------LEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKE 492
L+E +++ L+DT L L D + R + L++ ++
Sbjct: 1626 LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL----RSQEDLKEQLAMVERR 1681
Query: 493 REATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQE 552
Q IE+LR LE + + E+ S L + L + K+L+ +
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL----LHTQNTSLINTKKKLETD 1737
Query: 553 NYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQ 607
+++ + +D+ + + K + A A+ L E DT++ E M+ EQ
Sbjct: 1738 ISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792
Score = 44.7 bits (104), Expect = 3e-04
Identities = 75/375 (20%), Positives = 145/375 (38%), Gaps = 46/375 (12%)
Query: 245 DLGSSVS--SSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRK 302
DL S++ S A KM +L ++ + ++ L+NDL A+ L+ S
Sbjct: 1234 DLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE-EQQRLINDLTAQRARLQTESGE-- 1290
Query: 303 ISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNG 362
+ RQL S + F I+ + E++ L++
Sbjct: 1291 -----YSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS----- 1340
Query: 363 DLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELL 422
+ + L+ +E E+ K + A E + R Y E + E L
Sbjct: 1341 -------RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKY---ETDAIQRTEEL 1390
Query: 423 NARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKL 482
++L + + V + ++ L++ +QR+ + +ED + + + + +DK
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV-ERTNAACAALDKK 1449
Query: 483 RQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVEL 542
++N F K ++ E+ ELE Q RS S+ L F + E
Sbjct: 1450 QRN---FDKILAEWKQKCEETHAELEASQK---------ESRSLSTEL--FKIKNAYEES 1495
Query: 543 EHEVKRLKQENYKLRDQNDDLNGQIL--SLSLYE----AKNLFAAQTKAQSLAAEIDTAS 596
+++ LK+EN L+ + DL QI ++E K + +++ Q+ E + +
Sbjct: 1496 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASL 1555
Query: 597 RDELMEALKEQEEIN 611
E + L+ Q E+N
Sbjct: 1556 EHEEGKILRIQLELN 1570
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 60.5 bits (145), Expect = 5e-09
Identities = 66/268 (24%), Positives = 121/268 (45%), Gaps = 33/268 (12%)
Query: 365 KSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEAR--RHREAYGKLEREKATEVELL 422
KS L+ + +L ++ LEE V+ + E+ ++ R +A +L+R + E+E L
Sbjct: 1036 KSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGL 1095
Query: 423 NARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKL 482
R + L+ L L+ + E+L + QR S ++ +L + E + M D
Sbjct: 1096 LVRHRDLKANMRALELAHRELQGRHEQL--QAQRASVEAQEVALLAERE----RLMQDGH 1149
Query: 483 RQNRLE-----FQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARA 537
RQ LE Q E + Q L+ +L +E LQ + GE R
Sbjct: 1150 RQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGER----------------GELRGRL 1193
Query: 538 REVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKA-QSLAAEIDTAS 596
+ELE ++ + + +Q DL+ L+ L +AQ + + L AE+ S
Sbjct: 1194 ARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALS 1253
Query: 597 RD--ELME-ALKEQEEINFRLRQYMDKI 621
R+ EL+E +L+ ++ ++ R+Y+D++
Sbjct: 1254 RENRELLERSLESRDHLHREQREYLDQL 1281
Score = 43.9 bits (102), Expect = 5e-04
Identities = 79/398 (19%), Positives = 158/398 (39%), Gaps = 32/398 (8%)
Query: 264 VYNSELLDVYCSQCCKKINLLND-LEARLKNLKANSPN--RKISSTAFGRQLMHSSNFSS 320
V E L +Q +K L D LEA+ + L+A + R A R+ ++ +
Sbjct: 724 VAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREA 783
Query: 321 SNGSTEDL-FRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRV 379
+ E R+++++ ++ E V L G + + ++E ++L +
Sbjct: 784 EAQAWEQARLREAVEAAGQELESASQEREALVEALA----AAGRERRQWEREGSRLRAQS 839
Query: 380 HELEEMVKDQETTAEQALEEEARRHREAYG-KLEREKAT-EVELLNARVQQLEEENT--- 434
EE ++ E+ Q LEE R RE + E EKA + L AR++ L+ E
Sbjct: 840 EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
Query: 435 --------ELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNR 486
E + R + ++L+ E Q + E+ + LK + + +LRQ
Sbjct: 900 LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
Query: 487 LEFQKEREATQELIED-----LRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVE 541
++ A +L+E + E + + G+ + LG RA+E+
Sbjct: 960 AGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELL 1019
Query: 542 LEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELM 601
L+ + R ++ + +L+ + L +I L+ + + +A + E + L+
Sbjct: 1020 LQSQ--RAQEHSSRLQAEKSVL--EIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
Query: 602 EALKEQEEINFRLRQYMDKIILAILD--HNPSILEIKH 637
K ++ R ++ +++ D N LE+ H
Sbjct: 1076 RDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAH 1113
Score = 42.4 bits (98), Expect = 0.001
Identities = 55/221 (24%), Positives = 97/221 (43%), Gaps = 26/221 (11%)
Query: 369 KQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAY---------GKLEREKATEV 419
K + +L + E E++ D + Q LE E RR R+ +L RE+A +
Sbjct: 264 KAQLRRLRQELEEKAELLLDSQAEV-QGLEAEIRRLRQEAQALSGQAKRAELYREEAEAL 322
Query: 420 ELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYK--- 476
R+ +L+EE R + ++ +L+EER +S LE + L+++++ +
Sbjct: 323 RERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERV-LSGVLEASKALLEEQLEAARERC 381
Query: 477 -RMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCE-------RPGRGRSASS 528
R+ + R+N L + EA EL + LR +++ L ++ E P G +
Sbjct: 382 ARLHETQRENLLLRTRLGEAHAEL-DSLRHQVDQLAEENVELELELQRSLEPPPGSPGEA 440
Query: 529 GLGEFNARAREVELEHEVKRLK---QENYKLRDQNDDLNGQ 566
L ++ E E RL+ +EN +LR L GQ
Sbjct: 441 PLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQ 481
Score = 36.6 bits (83), Expect = 0.073
Identities = 35/139 (25%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 347 LEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHRE 406
LE+++ L+++ L ++L +E +L EL + E Q LE ++++ RE
Sbjct: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQ-LEMQSQQLRE 1212
Query: 407 AYGKLEREKA---TEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLED 463
+ +L+ T+ ELL EEEN +L V L + +L E D L
Sbjct: 1213 SNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHR 1272
Query: 464 TSLRLKDEMDLYKRMMDKL 482
D+++ +R KL
Sbjct: 1273 EQREYLDQLNALRREKQKL 1291
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 60.1 bits (144), Expect = 6e-09
Identities = 67/282 (23%), Positives = 117/282 (41%), Gaps = 48/282 (17%)
Query: 338 NDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMV---------KD 388
+D+ E++ EK ELE K KL E T L ++ EL+ + K+
Sbjct: 1037 SDLEERLKKEEKTRQELEK-------AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE 1089
Query: 389 QETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTE 448
+E A ++ H+ K+ RE L A++ +L+E+ + + + + Q
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRE-------LQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 449 KLDEERQRMSDRLEDT--------SLRLKDEM---DLYKRMMDKLRQNRLEFQKEREATQ 497
L EE + + LEDT LR K E +L K + ++ + + + Q R+
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 498 ELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLR 557
+E+L ++LE + +K + E+ +G + EL EVK L+Q +
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDN-----------KELACEVKVLQQVKAESE 1251
Query: 558 DQNDDLNGQI--LSLSLYEAKNL-FAAQTKAQSLAAEIDTAS 596
+ L+ Q+ L + E L KA L E+D S
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293
Score = 53.5 bits (127), Expect = 6e-07
Identities = 65/305 (21%), Positives = 125/305 (40%), Gaps = 36/305 (11%)
Query: 279 KKINL-LNDLEARLKNL-KANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSC 336
KK+ + L DLEA+++ KA K + + + S +++F S +S
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES- 1678
Query: 337 DNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQA 396
+K+ LE ++ +L+ + ++ + +QE +L + + + A
Sbjct: 1679 ----EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI--------TNSASGKSA 1726
Query: 397 LEEEARRHREAYGKLEREKATE---VELLNARVQQLEEENTELRTTVTRLKSQTEKLDEE 453
L +E RR +LE E E +ELLN R ++ + L + +S +K D
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786
Query: 454 RQRMSDRLEDTSLRL-----------KDEMDLYKRMMDKLRQNRLEFQKEREATQELIED 502
RQ++ + ++ +L K + + + +L + + KER A +L+
Sbjct: 1787 RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Query: 503 LRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREV-----ELEHEVKRLKQENYKLR 557
K+L+ + M D R + + NAR +++ E E E R KL+
Sbjct: 1847 TEKKLKEIFMQVEDERR--HADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Query: 558 DQNDD 562
+ DD
Sbjct: 1905 RELDD 1909
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/307 (22%), Positives = 127/307 (41%), Gaps = 40/307 (13%)
Query: 310 RQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLK 369
+QL+ N + E + + K LE+ + +LE+ + L+
Sbjct: 883 QQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942
Query: 370 QENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQL 429
E ++ + +LEE + D+E A Q KL+ EK T A+++++
Sbjct: 943 NEKKKMQAHIQDLEEQL-DEEEGARQ--------------KLQLEKVT----AEAKIKKM 983
Query: 430 EEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEF 489
EEE + L+ Q K +E++ M DR+ + S +L +E + K + K+R +
Sbjct: 984 EEE-------ILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA-KIRNKQEVM 1035
Query: 490 QKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRL 549
+ E + E R+ELE + KLD G + E A+ E++L+ K
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKR-KLD----GETTDLQDQIAELQAQIDELKLQLAKKEE 1090
Query: 550 KQENYKLRDQNDDLNG-------QILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELME 602
+ + R ++ L+ + L + E + F ++ KA AE E +E
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE-KASRNKAEKQKRDLSEELE 1149
Query: 603 ALKEQEE 609
ALK + E
Sbjct: 1150 ALKTELE 1156
Score = 51.6 bits (122), Expect = 2e-06
Identities = 78/358 (21%), Positives = 146/358 (40%), Gaps = 41/358 (11%)
Query: 284 LNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEK 343
L++ + K KAN K ++L + + R +D+ ++ K
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 344 VSF-------LEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQA 396
VS L +K ++L+N+ L + +++ + LE ++D ++
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD----TQEL 1323
Query: 397 LEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQT----EKLDE 452
L+EE R+ ++ R+ E L + ++ EE L V L+SQ +K+D+
Sbjct: 1324 LQEETRQKLNLSSRI-RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 453 ERQRMSDRLEDTSLRLKDEMDLYKRMMDK-LRQNRLEFQKEREATQELIEDLRKELEHLQ 511
+ + E LKD L +R+ +K L ++LE K R Q+ ++DL +L+H +
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR--LQQELDDLTVDLDHQR 1440
Query: 512 MYKLDCERPGRG--------RSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDL 563
+ E+ + +S S+ E RA E E K L
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL------------ 1488
Query: 564 NGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+ L +L EAK F Q K E +S+D++ + + E E+ L Q ++++
Sbjct: 1489 -ARALEEAL-EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544
Score = 47.0 bits (110), Expect = 5e-05
Identities = 57/243 (23%), Positives = 106/243 (43%), Gaps = 17/243 (6%)
Query: 350 KVTELENDSLTNGDLKSKLKQENTQLVHRVHELE----EMVKDQETTAEQALEEEARRHR 405
+VT E + + K+K++ T++ + E+E ++++++ AEQ L+ E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ-LQAETELFA 904
Query: 406 EAYGKLEREKATEVEL------LNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSD 459
EA R A + EL L +RV++ EE N L+ ++++ + L+E+
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 460 RLEDTSLRLKDEMDLYKRMMDK---LRQNRLEFQKEREATQELIEDLRKEL-EHLQMYKL 515
+ L K+M ++ L +F KE++ ++ I + +L E + K
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 516 DCERPGRGRSASSGLGEFNARAREV--ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLY 573
+ + S L E + + ELE ++L E L+DQ +L QI L L
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 574 EAK 576
AK
Sbjct: 1085 LAK 1087
Score = 46.2 bits (108), Expect = 9e-05
Identities = 59/257 (22%), Positives = 109/257 (42%), Gaps = 51/257 (19%)
Query: 386 VKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKS 445
VK+++T E LEE R+H++ L EK E L A + L E E+R RL +
Sbjct: 864 VKEKQTKVEGELEEMERKHQQ----LLEEKNILAEQLQAETE-LFAEAEEMRA---RLAA 915
Query: 446 QTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRK 505
+ ++L+E + R+E+ R N++ Q E++ Q I+DL +
Sbjct: 916 KKQELEEILHDLESRVEEEEER-----------------NQI-LQNEKKKMQAHIQDLEE 957
Query: 506 ELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNG 565
+L+ + G L + A A+ ++E E+ L+ +N K + +
Sbjct: 958 QLDEEE-----------GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 566 QILSLSLY------EAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMD 619
+I S +AKNL + K + + ++++ E LK++E+ L +
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE--------ERLKKEEKTRQELEKAKR 1058
Query: 620 KIILAILDHNPSILEIK 636
K+ D I E++
Sbjct: 1059 KLDGETTDLQDQIAELQ 1075
Score = 45.1 bits (105), Expect = 2e-04
Identities = 72/350 (20%), Positives = 136/350 (38%), Gaps = 34/350 (9%)
Query: 284 LNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEK 343
L+DL L + + + N + F + L + S+ D +
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 344 VSFLEKKVTELENDSLTNGDLKSKLKQ---ENTQLVHRVHELE-------EMVKDQETTA 393
LE+ + E N L++ ++ + VHELE + V++ T
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 394 EQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTE-LRTTVTRLKSQTEKLDE 452
E+ LE+E + +A +LE +Q +E+N E R + +++ +L++
Sbjct: 1549 EE-LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 453 ERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQM 512
ER++ R + + K E+D L+ + + +A E+I+ LRK ++
Sbjct: 1608 ERKQ---RALAVASKKKMEID--------LKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656
Query: 513 YKLDCERPGRGRS---ASSGLGEFNARAREVE---LEHEVKRLKQENYKLRDQNDDLNGQ 566
Y+ + E R A S E ++ E E L+ E+ ++ + D+L +
Sbjct: 1657 YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADE 1716
Query: 567 ILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQ 616
I + A A + + L A I +EL E E +N R R+
Sbjct: 1717 ITN----SASGKSALLDEKRRLEARI-AQLEEELEEEQSNMELLNDRFRK 1761
Score = 42.7 bits (99), Expect = 0.001
Identities = 44/205 (21%), Positives = 97/205 (47%), Gaps = 9/205 (4%)
Query: 341 TEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEE 400
T +V L ++ + + + + + +L+++N +L ++ ELE VK + ALE +
Sbjct: 1763 TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 401 ARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDR 460
+ E +LE+E A E N V++ E++ E+ V + ++ E+ ++ + R
Sbjct: 1823 IGQLEE---QLEQE-AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Query: 461 LEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERP 520
++ +LK +++ + + +R + Q+E + E E L +E+ L+ +L P
Sbjct: 1879 MK----QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK-NRLRRGGP 1933
Query: 521 GRGRSASSGLGEFNARAREVELEHE 545
S+ SG + + +EL +
Sbjct: 1934 ISFSSSRSGRRQLHLEGASLELSDD 1958
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 60.1 bits (144), Expect = 6e-09
Identities = 71/335 (21%), Positives = 142/335 (42%), Gaps = 22/335 (6%)
Query: 283 LLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSN----FSSSNGSTEDLFRDSIDSCDN 338
LL A L+ LK+ +++ RQL H S + ++++ +
Sbjct: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGET 1633
Query: 339 DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALE 398
++TEK + + + + LE S G+L ++ + TQL E+E+ +E + L
Sbjct: 1634 EVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEK----EEENLQVVLR 1689
Query: 399 EEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMS 458
+ ++ E L+ + EL ++Q ++ +EL K+Q L+E+ +
Sbjct: 1690 QMSKHKTELKNILDMLQLENHELQGLKLQH-DQRVSELE------KTQVAVLEEKLE--L 1740
Query: 459 DRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCE 518
+ L+ S + K E++ K+++++ ++ E A Q +E L KE E LQ E
Sbjct: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
Query: 519 RPGRGRSASSGLGEFNARAREVELEH---EVKRLKQENYKLRDQNDDLNGQILSLSLYEA 575
+ E N++ + LE V++L+QE +L L+ I ++
Sbjct: 1801 KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 1860
Query: 576 KNLFAAQTKAQSLAAEID--TASRDELMEALKEQE 608
+ A + + LA D ++ +L+ K Q+
Sbjct: 1861 EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQD 1895
Score = 47.0 bits (110), Expect = 5e-05
Identities = 68/323 (21%), Positives = 133/323 (41%), Gaps = 34/323 (10%)
Query: 291 LKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSC----DNDITEKVSF 346
L+NL+ S +K + +QL+ + E S C D+ EK
Sbjct: 1740 LENLQQISQQQK-GEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
Query: 347 LEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHRE 406
EKK+ + + L + SK++Q N + LE R+ ++
Sbjct: 1799 WEKKLAQTKR-VLAAAEENSKMEQSNLE---------------------KLELNVRKLQQ 1836
Query: 407 AYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSL 466
+L R+K + ++A QQL+E+ + + L + + L+ +Q + + +
Sbjct: 1837 ELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV 1896
Query: 467 RLKDEMDLYKRMMDKLRQNRLE-FQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRS 525
L ++ L K + + NR E QKE E Q+ ++ L+ E+E ++ + E +
Sbjct: 1897 LLSEQTRLQKDISE--WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ 1954
Query: 526 ASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKA 585
E +V L+ + +L++E L DQ L+ Q+LS L + + Q +
Sbjct: 1955 KERESEESKLETSKVTLKEQQHQLEKE---LTDQKSKLD-QVLSKVLAAEERVRTLQEEE 2010
Query: 586 QSLAAEIDTASRDELMEALKEQE 608
+ + T S+ + + +EQ+
Sbjct: 2011 RWCESLEKTLSQTKRQLSEREQQ 2033
Score = 46.2 bits (108), Expect = 9e-05
Identities = 62/310 (20%), Positives = 129/310 (41%), Gaps = 53/310 (17%)
Query: 331 DSIDSCDNDI---TEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVH------E 381
D I+ + I TE+ LE+ + +L+ S DL K QLV+++ E
Sbjct: 458 DEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLE 516
Query: 382 LEEMVKDQETTAEQ--------ALEE-EARRHREAYGKLERE-KATEVELLNARVQQLEE 431
L+ + QE +Q A++ +++ + ++ K ++ K +++++N + QQLE
Sbjct: 517 LQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLES 576
Query: 432 ENTELRTTVTRLKSQTEKLDEE--------RQRMSDRLEDTSLRLKDEMDLYKRMMDKLR 483
E+ + + + + + L+E+ + + LE L++ + K + +
Sbjct: 577 RLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQ 636
Query: 484 QNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELE 543
+ + E+E + + ++ +E + L++ +D E N R ELE
Sbjct: 637 NECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAE---------------NMRKELAELE 681
Query: 544 HEVKRLKQENYKLRDQNDDLNGQILSLSLYEAK---NLFAAQTKAQSLAAEIDTASRDEL 600
++ + N L+ D LS YEA+ L +A L E++ +R
Sbjct: 682 SALQEQHEVNASLQQTQGD-------LSAYEAELEARLNLRDAEANQLKEELEKVTRLTQ 734
Query: 601 MEALKEQEEI 610
+E Q E+
Sbjct: 735 LEQSALQAEL 744
Score = 43.5 bits (101), Expect = 6e-04
Identities = 82/422 (19%), Positives = 164/422 (38%), Gaps = 92/422 (21%)
Query: 287 LEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSF 346
LE L+ + K T F ++ + + S L + S + +D+ K
Sbjct: 275 LERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL 334
Query: 347 LEKKVTELENDSLTNGDLKS-----KLKQENTQLVHRVHELEEMVK--DQETTAEQALEE 399
L++K EL +L+ K+ + L + E E+ K D+ ++ +
Sbjct: 335 LKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYK 394
Query: 400 EARRHREAY----------GKLEREKATEVELLNARVQ-----QLEEENTELRTTVTRLK 444
E+Y K+E ++ + +N R QLE++ ++ TRL
Sbjct: 395 RNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLS 454
Query: 445 SQTEKLDEERQRMSDRLED-----TSLRLKDEMD-----LYKRM------MDKLRQNRLE 488
+++++ Q++ E+ +++LK + LYK++ ++KLRQ L+
Sbjct: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD 514
Query: 489 FQKEREATQELIEDLRKELEHLQMY--KLDCERPGRGRSASSGLGE------FNARAREV 540
+ + E ++ I +KE++ LQ+ LD + P + G+ N + +++
Sbjct: 515 LELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQL 574
Query: 541 E--LEHEVKRLKQENYKLRDQND---------------DLNGQILSLSLY---------- 573
E L+ + R+ +E +++D + DL G I L Y
Sbjct: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQ 634
Query: 574 ----------EAKNLFAAQTKAQSLAAEIDTASRD---------ELMEALKEQEEINFRL 614
E + L T+ + +++ + D EL AL+EQ E+N L
Sbjct: 635 AQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694
Query: 615 RQ 616
+Q
Sbjct: 695 QQ 696
Score = 43.5 bits (101), Expect = 6e-04
Identities = 59/308 (19%), Positives = 132/308 (42%), Gaps = 34/308 (11%)
Query: 326 EDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEM 385
+ L RD + S NDI+ L++K + + +++ L L+H + +
Sbjct: 1839 DQLNRDKL-SLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
Query: 386 VKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKS 445
+ +Q T ++ + E A R + ++E+ T+ + L ++EE +L + +
Sbjct: 1898 LSEQ-TRLQKDISEWANRFEDC----QKEEETKQQQLQVLQNEIEENKLKL----VQQEM 1948
Query: 446 QTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRK 505
++L +ER+ +LE + + LK++ ++ + + + + A +E + L++
Sbjct: 1949 MFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE 2008
Query: 506 ELEHLQMYKLDCERPGRGRSASSGLGEFNARARE-VELEHEVKRLKQENYKLRDQNDDLN 564
E + + ++ S + + R ++ VE E+ L++E +R L
Sbjct: 2009 EERWCESLE---------KTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLR 2059
Query: 565 GQILSLSLYEAKNLFAAQTKAQSLAAEIDTA---SRDELMEALKEQEEINFRLRQYMDKI 621
Q L+ + KA+ A + A R +L + L EQ++ N +++ M I
Sbjct: 2060 NQFLT-----------ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
Query: 622 ILAILDHN 629
L D++
Sbjct: 2109 ELVAQDNH 2116
Score = 37.4 bits (85), Expect = 0.043
Identities = 59/256 (23%), Positives = 111/256 (43%), Gaps = 41/256 (16%)
Query: 387 KDQETTAEQALEEEARRHRE--AYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLK 444
+D+ E+ L+EE +E A G+ E +A E L AR+ ++ E R + +++
Sbjct: 858 RDEAQVRERKLQEEMALQQEKLATGQEEFRQACE-RALEARMN-FDKRQHEAR--IQQME 913
Query: 445 SQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLR 504
++ L E + M + T L+L++ + +R++ +LR+ + + E +QE + L
Sbjct: 914 NEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLD 973
Query: 505 KELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLN 564
KEL+ L+ + K E +DQ L+
Sbjct: 974 KELKKLKKAVATSD----------------------------KLATAELTIAKDQLKSLH 1005
Query: 565 GQILSLSLYEAKNLFAAQ---TKAQSLAAEIDTASRD-ELMEALKEQEEINFRLRQYMDK 620
G ++ ++ A+ L A+ KA A ++ A + EL++ L Q+ FRL M+K
Sbjct: 1006 GTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLE--MEK 1063
Query: 621 IILAILDHNPSILEIK 636
+ N +LEI+
Sbjct: 1064 TGVG-TGANSQVLEIE 1078
Score = 36.6 bits (83), Expect = 0.073
Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 23/235 (9%)
Query: 395 QALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTR----LKSQ---T 447
++LE + ++ ER EVE L +++ E EL++ TR +K+Q
Sbjct: 248 ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307
Query: 448 EKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQEL-IEDLRKE 506
+ L EE E+ L + +L K+ +L + QK+ E QEL + +
Sbjct: 308 KSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTR---ACQKQYELEQELAFYKIDAK 364
Query: 507 LEHLQMYKLDCERPGRGRSASSGLGE-------FNARAREVELEHEVKRLKQE-NYKLRD 558
E L Y + + S +G+ F + ++ V+ K E + +LR+
Sbjct: 365 FEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRN 424
Query: 559 QNDDLNGQI-LSLSLYE-AKNLFAAQTKAQSLAAEIDTASRDEL--MEALKEQEE 609
+ +L G L L + K + AAQT+ L EI+ A + L E K+ EE
Sbjct: 425 DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEE 479
Score = 32.3 bits (72), Expect = 1.4
Identities = 40/174 (22%), Positives = 73/174 (41%), Gaps = 15/174 (8%)
Query: 460 RLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCER 519
RLED LK + KR +R ++ + +KE E I+DL +E + L+ + R
Sbjct: 1327 RLEDIMQHLKSK----KREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHR 1382
Query: 520 PGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLS-------- 571
+ R + N + ELE E K LK + D+ + + +L
Sbjct: 1383 TVQKRQQQKDFIDGNVESLMTELEIE-KSLKHHE-DIVDEIECIEKTLLKRRSELREADR 1440
Query: 572 -LYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILA 624
L EA++ + + A E T ++ L++ + EE+ R ++ ++ A
Sbjct: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
Score = 32.0 bits (71), Expect = 1.8
Identities = 58/294 (19%), Positives = 128/294 (43%), Gaps = 35/294 (11%)
Query: 348 EKKVTELENDSLTNGDLKSKLKQE----NTQLVHRVHELEEMVKDQETTAEQ--ALEEEA 401
EKK E E + L K + +++ N + + E+E+ +K E ++ +E+
Sbjct: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTL 1428
Query: 402 RRHREAYGKLER---EKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMS 458
+ R + +R E +E+ + + E+ T+ + ++ + +S E+L+ Q +
Sbjct: 1429 LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
Query: 459 DRLEDTSLRLKD-EMDLYKRMMDKLRQNRL-------------EFQKEREATQELIEDLR 504
L +L+ + D K++Q + +FQ + ++L E+L+
Sbjct: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ 1548
Query: 505 KELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVE-LEHEVKRLKQE----NYKLRDQ 559
K + ++M + + + + S L A+ E+E L+ +V +QE + +L +
Sbjct: 1549 KLQKDIEMAERNEDHHLQVLKESEVL--LQAKRAELEKLKSQVTSQQQEMAVLDRQLGHK 1606
Query: 560 NDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFR 613
++L+ +L S+ +AK A +A L T + + E EE++F+
Sbjct: 1607 KEELH--LLQGSMVQAK---ADLQEALRLGETEVTEKCNHIREVKSLLEELSFQ 1655
>gi|7662230 ring finger protein 40 [Homo sapiens]
Length = 1001
Score = 59.7 bits (143), Expect = 8e-09
Identities = 99/425 (23%), Positives = 164/425 (38%), Gaps = 84/425 (19%)
Query: 168 SVGSPAEKDGGLGGLFLPED-KSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVD 226
S +P +++GG G + P++ K + P TT+ S L+ +EE F+ G
Sbjct: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV-KKEELVPSEEDFQGITPGAQ-- 597
Query: 227 CAPSS------PCPDDETRTNVYSDLG-SSVSSSAGQTPRKMRHVYNSELLDVYCSQCCK 279
PSS P E R LG V+S+ + R+ V ++ K
Sbjct: 598 -GPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKR---------K 647
Query: 280 KINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDND 339
+ LL L A LK + + K+ + + E + + + +
Sbjct: 648 ESELLKGLRAELKKAQESQKEMKLLLDMY------------KSAPKEQRDKVQLMAAERK 695
Query: 340 ITEKVSFLEKKVTEL------ENDSLTNGDLKSKLKQENTQLVHRVHEL------EEMVK 387
+V L ++ EL E+ + + D +++Q Q+ H +L EE +
Sbjct: 696 AKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALL 755
Query: 388 DQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQ------LEEENTELRTTVT 441
+ QA E+ ++ +L + +L++ R++ L EE EL V
Sbjct: 756 SEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVL 815
Query: 442 RLKSQ-------TEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKER- 493
LKSQ +KL+E+ + + L L LR LE K +
Sbjct: 816 GLKSQVDAQLLTVQKLEEKERALQGSLGGVEKEL------------TLRSQALELNKRKA 863
Query: 494 -EATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQE 552
EA Q L EDL+ +LEH+Q R R L E A ARE E +KR +++
Sbjct: 864 VEAAQ-LAEDLKVQLEHVQT---------RLREIQPCLAESRA-AREKE-SFNLKRAQED 911
Query: 553 NYKLR 557
+LR
Sbjct: 912 ISRLR 916
Score = 39.3 bits (90), Expect = 0.011
Identities = 63/278 (22%), Positives = 107/278 (38%), Gaps = 29/278 (10%)
Query: 366 SKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLER----------EK 415
S++ + + +L RV EL + V + + + L E A+ H G+ R EK
Sbjct: 193 SRVVEASDRLQRRVEELCQRVYSRGDS--EPLSEAAQAHTRELGRENRRLQDLATQLQEK 250
Query: 416 ATEVEL----LNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKD- 470
+ L L +V E + E+ TTV L+ EKL + Q+++ L + +L
Sbjct: 251 HHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSG 310
Query: 471 -----EMDLYKRMMDKLRQNRLE-FQKEREATQELIEDLRKELEHLQMYKLDCERPG-RG 523
++ L + E E E QEL ELE LQ R R
Sbjct: 311 YYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERL 370
Query: 524 RSASSGLGEFNAR--AREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAA 581
+ A L E R L+ + L E+ +++ Q D+ G +L+ +++
Sbjct: 371 KVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHM 430
Query: 582 QTKAQSLAAEIDT---ASRDELMEALKEQEEINFRLRQ 616
++ L ++ T D L + KE E + Q
Sbjct: 431 ESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQ 468
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 59.7 bits (143), Expect = 8e-09
Identities = 98/404 (24%), Positives = 164/404 (40%), Gaps = 67/404 (16%)
Query: 279 KKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDN 338
+K +LL + + ++ L + +S A R L + E+ FR +++ +
Sbjct: 212 EKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQ---EETFR--LEAAKD 266
Query: 339 DITEKVSFLEKKVTEL--ENDSLTN-GDLKSKLKQENTQLVH---RVHELEEMVKDQETT 392
D + LEK+++EL +ND LT D LK E L H +V +LE V+ +
Sbjct: 267 DYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKK 326
Query: 393 AEQ-----------------------ALEEEARRHREAYGKLEREKATEVELLN------ 423
E +LEEE R+ A +LE K VEL N
Sbjct: 327 LEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEES 386
Query: 424 ARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKR-MMDKL 482
+ +L+ E L+ V L+ + ++L ER + + +E+ E L + +M
Sbjct: 387 KKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLG 446
Query: 483 RQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSA--SSGLGEFNARAREV 540
Q + T E+ E L + +M KL+ E + A S L + N R E+
Sbjct: 447 SQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNEL 506
Query: 541 ELEH--------EVKRLKQENYK-LRDQNDDLNGQILSLSLYE--AKNLFAAQTKAQSLA 589
E E+ EV+ +E K L+DQ +L E + L A + Q
Sbjct: 507 ETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKR 566
Query: 590 AEID---------TASRDELMEALKEQEE----INFRLRQYMDK 620
A I+ + +EL EAL+++EE + R ++Y++K
Sbjct: 567 AIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEK 610
Score = 45.8 bits (107), Expect = 1e-04
Identities = 82/358 (22%), Positives = 140/358 (39%), Gaps = 64/358 (17%)
Query: 287 LEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSF 346
LE L+ KAN+ ++ + + RQ++ N S E D +D + EKV
Sbjct: 354 LEEELR--KANAARSQLET--YKRQVVELQNRLSE----ESKKADKLDFEYKRLKEKVDS 405
Query: 347 LEKKVTEL--ENDSL--TNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEAR 402
L+K+ L E DSL T +L+ QE + L AE E
Sbjct: 406 LQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIRE 465
Query: 403 R-----HREAYGKLEREKATEVELL---------NARVQQLEEENTELRTTVTRLKSQTE 448
+ H KL +E + ++ N R +LE EN + + ++SQ E
Sbjct: 466 KLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVE 525
Query: 449 KLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELE 508
+L + Q + ED S+ LK +++ + ++KL + E QK+R +IEDL
Sbjct: 526 ELQKSLQDQGSKAED-SVLLKKKLEEH---LEKLHEANNELQKKR----AIIEDLEP--- 574
Query: 509 HLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQ--NDDLNGQ 566
FN + ++E E R K+E K ++ L
Sbjct: 575 -----------------------RFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKA 611
Query: 567 ILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILA 624
+ + K A + Q+L ++ RD L +L+++ E R+ +K I++
Sbjct: 612 KSVIRTLDPKQNQGAAPEIQALKNQLQ--ERDRLFHSLEKEYEKTKSQREMEEKYIVS 667
Score = 40.4 bits (93), Expect = 0.005
Identities = 54/279 (19%), Positives = 113/279 (40%), Gaps = 32/279 (11%)
Query: 370 QENTQLVHRVHELEEMVKDQETTAEQAL---EEEARRHREAYGKLEREKATEVELLNARV 426
++ + + + +EE V+ TA Q L E +AY L+R+ E LN +
Sbjct: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
Query: 427 ---QQLEEENTELRTTVTRLKSQTEKLDEERQ------RMSDRLEDTSLRLKDEMDLYKR 477
+++ + EL V L+ + L E Q SD +ED + +
Sbjct: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQT 249
Query: 478 MMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARA 537
+++L++ + ++ + E+L KE+ L+ + + E A S E +
Sbjct: 250 QLEQLQEETFRLEAAKDDYRIRCEELEKEISELR--QQNDELTTLADEAQSLKDEIDVLR 307
Query: 538 REVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQT---------KAQSL 588
+ +V +L+ + + + +DL + L E KN Q KA +
Sbjct: 308 HSSD---KVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAA 364
Query: 589 AAEIDTASR------DELMEALKEQEEINFRLRQYMDKI 621
++++T R + L E K+ ++++F ++ +K+
Sbjct: 365 RSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKV 403
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/361 (21%), Positives = 157/361 (43%), Gaps = 50/361 (13%)
Query: 283 LLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITE 342
+L++L +LKN + ++ + + G Q S + + ++ ++ +
Sbjct: 330 MLHNLREKLKNAQLDADKSNVMALQQGIQ---------ERDSQIKMLTEQVEQYTKEMEK 380
Query: 343 KVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEAR 402
+E +L+N+ N + +Q + ++ + L+E K+ E TAE A +
Sbjct: 381 NTCIIE----DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADARE 436
Query: 403 RHREAYGKLEREKATE--VELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDR 460
+ +E L+R K E V L V +++ +++ ++ T+++++ ++SD
Sbjct: 437 KDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDF 496
Query: 461 LEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERP 520
L++ L++ + L + M L + R +++ + + L KE+E L+ +LD ++
Sbjct: 497 LDENE-ALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKK 555
Query: 521 GR-------GRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLY 573
R RSA+SGL ++ L + Q D ++ + L L
Sbjct: 556 IRQMAQERGKRSATSGL-----TTEDLNLTENI-----------SQGDRISER--KLDLL 597
Query: 574 EAKNLFAAQTKAQSLAAEIDTASRD---------ELMEALKEQEEINFRLRQYMDKIILA 624
KN+ AQ+K + L+ E+ RD + LKE E N +L + M +I+ A
Sbjct: 598 SLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQA 657
Query: 625 I 625
I
Sbjct: 658 I 658
Score = 57.0 bits (136), Expect = 5e-08
Identities = 72/343 (20%), Positives = 147/343 (42%), Gaps = 61/343 (17%)
Query: 257 TPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSS 316
T +K H+ +++D + + ++ LN+ +LK S NR+ S T
Sbjct: 1767 TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLT---------- 1816
Query: 317 NFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLV 376
D+++ +N++ +K K + E E N +LK ++K+ + L
Sbjct: 1817 --------------DNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQ 1862
Query: 377 HR---------VHELEEMVKDQETTAEQALEE-EARRHREAYGKLE-------REKATEV 419
+ + EL+ VK E E +EE + + +E K E ++ ++
Sbjct: 1863 GKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKI 1922
Query: 420 ELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRL----------- 468
E + ++++ E E L + LK K D+E+ + +L+ T + +
Sbjct: 1923 EGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALES 1982
Query: 469 -KDEMDLYKRMMDKLRQNRLEFQKEREA--TQELIEDLRKELEHLQ--MYKLDCE--RPG 521
K+ +L KR +D +N + + + +A ++EDL + +LQ ++ L+ + +
Sbjct: 1983 EKELEELKKRNLD--LENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT 2040
Query: 522 RGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLN 564
+ + SG+ + RE EL+ E +L EN +L+ Q + N
Sbjct: 2041 YSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQAN 2083
Score = 51.6 bits (122), Expect = 2e-06
Identities = 69/291 (23%), Positives = 118/291 (40%), Gaps = 62/291 (21%)
Query: 339 DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALE 398
DI +K + L ++ + LE+ N LK +++ N +L E+ K++ T EQA E
Sbjct: 978 DILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL--------EITKEKLHTIEQAWE 1029
Query: 399 EEARRHREAYGKLEREKAT--------------EVELLNAR----------------VQQ 428
+E + E+ ++ T E++ LN R ++Q
Sbjct: 1030 QETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQ 1089
Query: 429 LEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLE 488
+EE N EL T L + Q + D L D+ + + D ++ + +L +N +E
Sbjct: 1090 MEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDAD--RQRILELEKNEME 1147
Query: 489 FQKEREATQELIEDLR--------------KELEHLQMYKLDCERPGRGRSASSGLGEFN 534
+ E +E+ + R KE+E L+M LD + +S + L + N
Sbjct: 1148 LKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHN 1207
Query: 535 ARAREVE------LEHEVKRL-KQENYKLR-DQNDDLNGQILSLSLYEAKN 577
+ E LE +L K E Y LR +Q D Q L + E +N
Sbjct: 1208 VSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRN 1258
Score = 49.3 bits (116), Expect = 1e-05
Identities = 45/177 (25%), Positives = 85/177 (48%), Gaps = 17/177 (9%)
Query: 348 EKKVTELENDSLTNG----DLKSKLKQ--ENTQLVHRVHE-LEEMVK-----DQETTAEQ 395
E K+ ELE D DLK +K+ E Q V++ +E LE+ +K + EQ
Sbjct: 2276 ETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335
Query: 396 ALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENT-----ELRTTVTRLKSQTEKL 450
L+ E + R A +L++EKA + + A Q E+T +L+ + L++Q +
Sbjct: 2336 GLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMS 2395
Query: 451 DEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKEL 507
D E+Q + + ++ L++ + ++ L+ N E K+ +E ++ L ++L
Sbjct: 2396 DLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
Score = 47.8 bits (112), Expect = 3e-05
Identities = 70/352 (19%), Positives = 146/352 (41%), Gaps = 67/352 (19%)
Query: 320 SSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDL----------KSKLK 369
S+ G R+ I + + +K LE ELE + N L SKL+
Sbjct: 104 SAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLR 163
Query: 370 QENTQLVHRVHEL-EEMVKDQETTAEQALEEEARRHREAYGKLEREKAT--------EVE 420
+EN +L + +L ++++ Q+ Q +RR ++ + + K E++
Sbjct: 164 RENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQ 223
Query: 421 LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSL---RLKDEMDLYKR 477
L +++E +N E+R + + EK+ +E RM + T +LK E D Y+
Sbjct: 224 TLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQL 283
Query: 478 MMDKLRQNRLEFQKERE--------------------------ATQELIEDLRKELEHLQ 511
+ +L + L+ + E + Q+++ +LR++L++ Q
Sbjct: 284 QVQEL-TDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQ 342
Query: 512 MYKLDCERPGRGRSASSGLGEFNARAREV--ELEHEVKRLKQENYKLRDQNDDLN----- 564
LD ++ + G+ E +++ + + ++E K +++ + D ++L
Sbjct: 343 ---LDADK-SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGA 398
Query: 565 ---GQILSLSLYEAKNLFAAQTKAQSLAAEI---DTASRD-ELMEALKEQEE 609
Q + + ++ +TK AE+ D +D EL+EALK ++
Sbjct: 399 STLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKD 450
Score = 39.3 bits (90), Expect = 0.011
Identities = 68/340 (20%), Positives = 135/340 (39%), Gaps = 59/340 (17%)
Query: 279 KKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDN 338
K++N L DL A+ K RK+ +T + S E+L + ++D +N
Sbjct: 1941 KQLNTLKDLFAKADKEKLTL-QRKLKTTGMTVDQVLGIRALESEKELEELKKRNLD-LEN 1998
Query: 339 DITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALE 398
DI + + +L + L +N L ++H LE+ +
Sbjct: 1999 DILYMRA----------HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISG 2048
Query: 399 EEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMS 458
E+ H + R Q+L++EN +L + LK Q E+ +++ R+
Sbjct: 2049 IESDDHCQ------------------REQELQKENLKLSSENIELKFQLEQANKDLPRLK 2090
Query: 459 DRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCE 518
+++ D LK+ + K+ ++ Q +L + + + I +L K + ++ +
Sbjct: 2091 NQVRD----LKEMCEFLKKEKAEV-QRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQ 2145
Query: 519 RPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLN---GQILSLSLYEA 575
R +SG + ++ ++QEN KL+ + + L G LS+ YE+
Sbjct: 2146 RENEQLKKASG----------ILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMH-YES 2194
Query: 576 KNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLR 615
K + E A + L + LK++ + +LR
Sbjct: 2195 K----------TKGTEKIIAENERLRKELKKETDAAEKLR 2224
Score = 36.2 bits (82), Expect = 0.095
Identities = 57/284 (20%), Positives = 122/284 (42%), Gaps = 54/284 (19%)
Query: 378 RVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQ-QLEEENTEL 436
R+++ EE++K + E+A EE+ RE K E + + +L+ R++ Q + +
Sbjct: 1548 RLNQKEEVLKKYQRLLEKAREEQ----REIVKKHEED----LHILHHRLELQADSSLNKF 1599
Query: 437 RTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREAT 496
+ T L Q+ + RL + + ++ D ++ KL++ + +++RE T
Sbjct: 1600 KQTAWDLMKQSPTPVPTNKHFI-RLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREIT 1658
Query: 497 ------------------QELIEDLRKELEHLQMYKLDCERPGRG--RSASSGLGEFNAR 536
++ ++ ++ E+E L+ Y LD + +S E N+R
Sbjct: 1659 ELKVKEFENIKLQLQENHEDEVKKVKAEVEDLK-YLLDQSQKESQCLKSELQAQKEANSR 1717
Query: 537 AREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTAS 596
A + + V+RLK + Q L+ +L L AE+ A+
Sbjct: 1718 APTTTMRNLVERLKSQLALKEKQQKALSRALL------------------ELRAEMTAAA 1759
Query: 597 RDELMEALKEQEEINFRLRQYMDK----IILAILDHNPSILEIK 636
+ ++ A Q+E + ++Q +D+ + + D N ++L++K
Sbjct: 1760 EERIISA-TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLK 1802
Score = 35.4 bits (80), Expect = 0.16
Identities = 37/170 (21%), Positives = 77/170 (45%), Gaps = 13/170 (7%)
Query: 349 KKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEE-ARRHREA 407
K + +L+ND L +QE+ + ++ E+E +K E + + A++
Sbjct: 1288 KTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINW 1347
Query: 408 YGKLEREKATEVELLNARVQQLEEEN------TELRTTVTRLKS---QTEKLDEERQRMS 458
+ K+E + E++L V+ EE +E T++ L+ Q K EERQ
Sbjct: 1348 HMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAW 1407
Query: 459 DRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELE 508
D+ E + L+ ++D++ R +++ +F++ + + L +LE
Sbjct: 1408 DQRE---VDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLE 1454
Score = 33.5 bits (75), Expect = 0.61
Identities = 67/353 (18%), Positives = 134/353 (37%), Gaps = 50/353 (14%)
Query: 286 DLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVS 345
DL+ +++ + R +S L + N S + +E ++ K
Sbjct: 551 DLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNE 610
Query: 346 FLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHR 405
FL +++ E E D + + +K + + +LV +LEE +K+ QA++E +
Sbjct: 611 FLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKE----ILQAIKEMQKDPD 666
Query: 406 EAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTS 465
G E + + L V +E +N E + D S
Sbjct: 667 VKGG----ETSLIIPSLERLVNAIESKNAE------------------------GIFDAS 698
Query: 466 LRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQM-YKLDCERPG--- 521
L LK ++D ++LRQ E +KE + + +++HL+ L + G
Sbjct: 699 LHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNV 758
Query: 522 --RGRSASSGLGEFNA---RAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAK 576
+G G+ +A ++ L H ++ L+ + KL++ D SL +
Sbjct: 759 VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLED---------SLEDYN 809
Query: 577 NLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHN 629
FA QSL + + ++ K +E +L + + + + ++N
Sbjct: 810 RKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYN 862
Score = 30.0 bits (66), Expect = 6.8
Identities = 51/272 (18%), Positives = 101/272 (37%), Gaps = 19/272 (6%)
Query: 349 KKVTELENDSLTNGDLKSKLKQENTQL-----------VHRVHELEEMVKDQETTAEQAL 397
K + ELE + K+++EN QL + + + E +K + + L
Sbjct: 2125 KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHL 2184
Query: 398 EEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRM 457
+ H E+ K + E E L +++ + +LR L+ EK+ + +
Sbjct: 2185 GHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEET 2244
Query: 458 SDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDC 517
RL+ R + + R+ K +E ++ + + + Q+ K
Sbjct: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304
Query: 518 ERPGRGRSASSGLGEFNARAREVELEHEVKR-LKQENYKLRDQNDDLNGQILSLSLYEAK 576
ER + + L + + V E ++ LK+E LR N L+ + +A+
Sbjct: 2305 EREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKE-------KAE 2357
Query: 577 NLFAAQTKAQSLAAEIDTASRDELMEALKEQE 608
+ + AE D+L E +K+ E
Sbjct: 2358 LIHQIEANKDQSGAESTIPDADQLKEKIKDLE 2389
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 59.3 bits (142), Expect = 1e-08
Identities = 50/221 (22%), Positives = 98/221 (44%), Gaps = 8/221 (3%)
Query: 349 KKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAY 408
+K E E + + + + ++EN E +++ET E + + R R+
Sbjct: 176 QKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQ 235
Query: 409 GKLEREKATEVELLNA------RVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLE 462
K ERE+ + E A R ++ E E R R K + + D +RQR ++R
Sbjct: 236 RKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR 295
Query: 463 DTSLRLKDEMDLYK-RMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPG 521
+T + + + + + R ++ R+ E ++ERE +E D KE E + + + +R
Sbjct: 296 ETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRER 355
Query: 522 RGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDD 562
++ G + R RE E E + + ++ + RD++ D
Sbjct: 356 NRQTGREGRRQAE-RERERERERDRQSAREREERERDRDRD 395
Score = 48.9 bits (115), Expect = 1e-05
Identities = 47/183 (25%), Positives = 75/183 (40%), Gaps = 14/183 (7%)
Query: 370 QENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQL 429
+E + R E+ ++ET ++ E RHR+ ER++ E E R +Q
Sbjct: 54 RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKE----RERQT 109
Query: 430 EEENTELRTTV-TRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYK---RMMDKLRQN 485
+ E R R K + + + E +R DR D + + D K R D+ RQ
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169
Query: 486 RLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHE 545
+ E +++E +E R+E E + E+ + S G R RE E E E
Sbjct: 170 QTERNRQKEREREKNRQERRERERQR------EKENKTEDRHSERGRERERERETETETE 223
Query: 546 VKR 548
KR
Sbjct: 224 RKR 226
Score = 48.5 bits (114), Expect = 2e-05
Identities = 48/218 (22%), Positives = 95/218 (43%), Gaps = 11/218 (5%)
Query: 353 ELENDSLTNGDLKSKLKQENTQLVHRVHELE---EMVKDQETTAEQALEEEARRHREAYG 409
E E + T+ + + ++E + R E E E +D++T ++ E R R+A
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQR----ERERQRDAEK 157
Query: 410 KLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLK 469
+ ER+ E + R +Q E E + R + Q EK ++ R S+R + +
Sbjct: 158 ERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERE 217
Query: 470 DEMDLYKRMM---DKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSA 526
E + ++ ++ RQ + E ++E++A +E + E + + + D +R R
Sbjct: 218 TETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQK 277
Query: 527 SSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLN 564
R R E + E +R K+E + R++ + N
Sbjct: 278 ERERQTDRKRQRRTERDRETER-KRERQRERERERERN 314
Score = 43.9 bits (102), Expect = 5e-04
Identities = 54/212 (25%), Positives = 85/212 (40%), Gaps = 18/212 (8%)
Query: 350 KVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYG 409
K E E D + D + K ++ T + E ++ E E+ E E R R
Sbjct: 260 KERERERDRDRDRDRRQKERERQTD--RKRQRRTERDRETERKRERQRERERERERNRKR 317
Query: 410 KLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDR-------LE 462
+ ERE+ E R +Q E E + + K QTE +D ER R + R E
Sbjct: 318 ERERERERE------RERQRETERDREKERERKRKRQTE-MDRERNRQTGREGRRQAERE 370
Query: 463 DTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCE-RPG 521
R +D +R ++ R + QKERE E D ++E E + + D E G
Sbjct: 371 RERERERDRQSARER-EERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERG 429
Query: 522 RGRSASSGLGEFNARAREVELEHEVKRLKQEN 553
R R + R RE + + + R ++ +
Sbjct: 430 RERGREREKQKGRERDRERQTDRQAGRQRKRS 461
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 59.3 bits (142), Expect = 1e-08
Identities = 65/312 (20%), Positives = 145/312 (46%), Gaps = 25/312 (8%)
Query: 284 LNDLEARLKNLKANSPNRKISSTA--FGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDIT 341
+ DL+ +L+ + P +++ A G++L S + +L+ + +
Sbjct: 241 VKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELW----NLLNQQQE 296
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENT-QLVHRVHELEEMVKDQETTAEQALEEE 400
EK+ E+K+ E E + + +LK + ++E + ++HE EE +++QE + EE+
Sbjct: 297 EKMWRQEEKIQEQE-EKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ-EEK 354
Query: 401 ARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEE--RQRMS 458
R E + E + + E + + ++++E+ E+ +++ Q EK E+ RQ
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414
Query: 459 DRLEDTSLRLKDE---------MDLYKRMMD---KLRQNRLEFQKEREATQELIEDLRKE 506
R +D +R ++E +L + M D KLR+ + Q+E E QE E ++++
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQ 474
Query: 507 LEHLQMYKLDCERPGRGRSASSGLGEFNAR--AREVELEHEVKRLKQENYKLRDQNDDLN 564
E +Q + R + + E + +E ++ + ++++++ K++ Q + +
Sbjct: 475 EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR 534
Query: 565 GQILSLSLYEAK 576
Q + L E K
Sbjct: 535 EQEVRLWQQEEK 546
Score = 41.6 bits (96), Expect = 0.002
Identities = 52/213 (24%), Positives = 97/213 (45%), Gaps = 30/213 (14%)
Query: 428 QLEEENTELRTTV-----TRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKL 482
Q EN+ L T+ R+ + EKL +ER S L ++ ++ + + +KL
Sbjct: 168 QKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKL 227
Query: 483 RQNRLEFQKEREATQELIEDLRKELEHLQM----YKLDCERPGRGRSASSGLGEFNARAR 538
R + E+ Q ++DL+++LE Q+ +L E G+ S + A+
Sbjct: 228 RL----VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE 283
Query: 539 EVEL------EHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTK----AQSL 588
E EL + E K +QE K+++Q + + Q L + E K ++ + K + +
Sbjct: 284 ENELWNLLNQQQEEKMWRQEE-KIQEQEEKMCEQELKIREQEEK-MWRQEEKMHEQEEKI 341
Query: 589 AAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+ D R E E ++EQEE ++R+ +K+
Sbjct: 342 REQEDKMWRQE--EKIREQEE---KIREQEEKM 369
Score = 39.3 bits (90), Expect = 0.011
Identities = 74/395 (18%), Positives = 167/395 (42%), Gaps = 53/395 (13%)
Query: 290 RLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEK--VSFL 347
+L ++A NRK T + S E L R + D++ E VS +
Sbjct: 65 QLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHV 124
Query: 348 EKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALE--------- 398
+K E+++ + K+ ++N RV + ++ E TA++ E
Sbjct: 125 KKNSDEVKSSFKKR---QEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLH 181
Query: 399 -EEARRHREAYGKLEREK-ATEVELLNARV--QQLEEENTELRTTVTRLKSQ-------- 446
+ A R KL +E+ A +EL + ++L+E+N EL+ + ++S+
Sbjct: 182 FDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNV 241
Query: 447 ---------------TEKLDEERQRMSDRLEDTSLRLKDEMD-------LYKRMMDKL-- 482
++L E R+ L+ S +L+ +++ L ++ +K+
Sbjct: 242 KDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWR 301
Query: 483 RQNRLEFQKEREATQEL-IEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVE 541
++ +++ Q+E+ QEL I + +++ + + E R + E R +E +
Sbjct: 302 QEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK 361
Query: 542 LEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELM 601
+ + +++ ++ K+R+Q++ + Q + E K + + K Q + R++
Sbjct: 362 IREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEK-IREQEEKRQEKMWRQEKKMREQ-D 419
Query: 602 EALKEQEEINFRLRQYMDKIILAILDHNPSILEIK 636
E ++EQEE +R + + ++ + D + E++
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 59.3 bits (142), Expect = 1e-08
Identities = 65/312 (20%), Positives = 145/312 (46%), Gaps = 25/312 (8%)
Query: 284 LNDLEARLKNLKANSPNRKISSTA--FGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDIT 341
+ DL+ +L+ + P +++ A G++L S + +L+ + +
Sbjct: 241 VKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELW----NLLNQQQE 296
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENT-QLVHRVHELEEMVKDQETTAEQALEEE 400
EK+ E+K+ E E + + +LK + ++E + ++HE EE +++QE + EE+
Sbjct: 297 EKMWRQEEKIQEQE-EKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ-EEK 354
Query: 401 ARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEE--RQRMS 458
R E + E + + E + + ++++E+ E+ +++ Q EK E+ RQ
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414
Query: 459 DRLEDTSLRLKDE---------MDLYKRMMD---KLRQNRLEFQKEREATQELIEDLRKE 506
R +D +R ++E +L + M D KLR+ + Q+E E QE E ++++
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQ 474
Query: 507 LEHLQMYKLDCERPGRGRSASSGLGEFNAR--AREVELEHEVKRLKQENYKLRDQNDDLN 564
E +Q + R + + E + +E ++ + ++++++ K++ Q + +
Sbjct: 475 EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR 534
Query: 565 GQILSLSLYEAK 576
Q + L E K
Sbjct: 535 EQEVRLWQQEEK 546
Score = 43.1 bits (100), Expect = 8e-04
Identities = 52/213 (24%), Positives = 98/213 (46%), Gaps = 30/213 (14%)
Query: 428 QLEEENTELRTTV-----TRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKL 482
Q EN+ L T+ R+ + EKL +ER +S L ++ ++ + + +KL
Sbjct: 168 QKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKL 227
Query: 483 RQNRLEFQKEREATQELIEDLRKELEHLQM----YKLDCERPGRGRSASSGLGEFNARAR 538
R + E+ Q ++DL+++LE Q+ +L E G+ S + A+
Sbjct: 228 RL----VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE 283
Query: 539 EVEL------EHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTK----AQSL 588
E EL + E K +QE K+++Q + + Q L + E K ++ + K + +
Sbjct: 284 ENELWNLLNQQQEEKMWRQEE-KIQEQEEKMCEQELKIREQEEK-MWRQEEKMHEQEEKI 341
Query: 589 AAEIDTASRDELMEALKEQEEINFRLRQYMDKI 621
+ D R E E ++EQEE ++R+ +K+
Sbjct: 342 REQEDKMWRQE--EKIREQEE---KIREQEEKM 369
Score = 39.3 bits (90), Expect = 0.011
Identities = 74/395 (18%), Positives = 167/395 (42%), Gaps = 53/395 (13%)
Query: 290 RLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEK--VSFL 347
+L ++A NRK T + S E L R + D++ E VS +
Sbjct: 65 QLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHV 124
Query: 348 EKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALE--------- 398
+K E+++ + K+ ++N RV + ++ E TA++ E
Sbjct: 125 KKNSDEVKSSFKKR---QEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLH 181
Query: 399 -EEARRHREAYGKLEREK-ATEVELLNARV--QQLEEENTELRTTVTRLKSQ-------- 446
+ A R KL +E+ A +EL + ++L+E+N EL+ + ++S+
Sbjct: 182 FDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNV 241
Query: 447 ---------------TEKLDEERQRMSDRLEDTSLRLKDEMD-------LYKRMMDKL-- 482
++L E R+ L+ S +L+ +++ L ++ +K+
Sbjct: 242 KDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWR 301
Query: 483 RQNRLEFQKEREATQEL-IEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVE 541
++ +++ Q+E+ QEL I + +++ + + E R + E R +E +
Sbjct: 302 QEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK 361
Query: 542 LEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELM 601
+ + +++ ++ K+R+Q++ + Q + E K + + K Q + R++
Sbjct: 362 IREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEK-IREQEEKRQEKMWRQEKKMREQ-D 419
Query: 602 EALKEQEEINFRLRQYMDKIILAILDHNPSILEIK 636
E ++EQEE +R + + ++ + D + E++
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/230 (19%), Positives = 116/230 (50%), Gaps = 20/230 (8%)
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTA---EQALE 398
EK+ EK+ E + + + K + ++E + ++HE EE ++ QE E+ +
Sbjct: 511 EKIREEEKRQ---EQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 399 EEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMS 458
++ + RE K+ R++ E + + +++ E+ ++R + Q EK+ E+ ++M
Sbjct: 568 DQEEKIREQEEKVWRQE----EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC 623
Query: 459 DRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHL-QMYKLDC 517
++ E +++++ + +R +K+R+ + +++ E +E E ++++ E + + + C
Sbjct: 624 EQEE----KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Query: 518 ERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQI 567
E+ + + E R +E ++ + RL+Q+ K+++ + L I
Sbjct: 680 EQEEKMQEQ-----EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 50.8 bits (120), Expect = 4e-06
Identities = 53/284 (18%), Positives = 125/284 (44%), Gaps = 17/284 (5%)
Query: 342 EKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTA-------- 393
EK+ E+K+ E E ++ + +++ + + E EE ++ QE
Sbjct: 382 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 394 --EQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLD 451
E+ + E+ + + + E EK E E + ++ + ++R +++ Q EK+
Sbjct: 442 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMW 501
Query: 452 EERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHL- 510
+ +++ ++ + + E + R +K+R+ E +++E E E +RK+ E +
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE-EIWRQKEKIHEQEEKIRKQEEKMW 560
Query: 511 -QMYKL-DCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQIL 568
Q K+ D E R + E R +E ++ + ++++++ ++Q + + Q
Sbjct: 561 RQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 620
Query: 569 SLSLYEAKNLFAAQTKAQSLAAEIDTASRD--ELMEALKEQEEI 610
+ E K + + K + +I + E E ++EQEE+
Sbjct: 621 KMCEQEEK-MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 663
Score = 35.8 bits (81), Expect = 0.12
Identities = 60/310 (19%), Positives = 121/310 (39%), Gaps = 41/310 (13%)
Query: 344 VSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARR 403
+ L + TEL+ + +L+ E L+ R+H+ + + E ++ +
Sbjct: 193 IRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKA 252
Query: 404 HREAYGKLEREKATEVELLNARV--QQLEEEN--------------TELRTTVTRLKSQT 447
R + A +EL + ++L+E+N +E++ V LK +
Sbjct: 253 DRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL 312
Query: 448 EK---------LDEERQRMSDRLEDTSLRLK---DEMDLYKRM----MDKLRQNRLEFQK 491
E+ L E + L+ S +L+ +E +L+ R+ +K+ + + Q+
Sbjct: 313 ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 372
Query: 492 EREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQ 551
E QE E +R++ E ++ + E+ R E R E+ E E K +Q
Sbjct: 373 WEEKIQEQEEKIREQEEKIREQE---EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 429
Query: 552 ENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEIN 611
E + + L ++E + + + K Q + R E + QEE
Sbjct: 430 EEMMWEKEE---KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-- 484
Query: 612 FRLRQYMDKI 621
++R+ +KI
Sbjct: 485 -KIREQEEKI 493
>gi|215982794 myosin VA isoform 2 [Homo sapiens]
Length = 1828
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/325 (25%), Positives = 139/325 (42%), Gaps = 60/325 (18%)
Query: 282 NLLND---LEARLKNLKAN--------SPNRKISSTAFGRQLMHSSN-----FSSSNGST 325
NLLN+ LE R +LK P K + + HSSN FSS
Sbjct: 1080 NLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDST------HSSNESEYIFSSEIAEM 1133
Query: 326 EDLFRDSIDSCDNDITEKVSF---LEKKVTELENDSLTNGD---------LKSKLKQENT 373
ED+ + + + + +S L+K+VTELE + D L+SK K+E
Sbjct: 1134 EDIPSRTEEPSEKKVPLDMSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEER 1193
Query: 374 QLVHRVHELEEMVKDQETTAE-QALEEEARRHREAYGKLEREKATE---------VELLN 423
+ E +K QE +E + L+ E R+A + + T +E L
Sbjct: 1194 PQIRGAELEYESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLT 1253
Query: 424 ARVQQLEEENTELRTTVTRLKSQTEKLD--EERQRMSDR---LEDTSLRLKDEMDLYKRM 478
+ ++L+ E+ ++L SQ E + +++ M+D LED ++KD+ ++ +
Sbjct: 1254 SVSEELDVRKEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQ-KMKDKGEIAQAY 1312
Query: 479 MDKLRQNRL---EFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNA 535
+ NRL + Q ++ + + E LR E++ L+ E R + + +
Sbjct: 1313 IGLKETNRLLESQLQSQKRSHENEAEALRGEIQSLK------EENNRQQQLLAQNLQLPP 1366
Query: 536 RAR-EVELEHEVKRLKQENYKLRDQ 559
AR E L+HE+ RL EN L +Q
Sbjct: 1367 EARIEASLQHEITRLTNENLDLMEQ 1391
Score = 48.9 bits (115), Expect = 1e-05
Identities = 58/247 (23%), Positives = 107/247 (43%), Gaps = 37/247 (14%)
Query: 340 ITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEE 399
+ E+++ L K + + ++ + + KQE QLV + E ++K ++ + +
Sbjct: 988 LQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQ 1047
Query: 400 EARRHREAYGKLEREKATEVEL------------------LNARVQQLEEENTEL----- 436
+A+ E K E+ ++EL L R L+EE T +
Sbjct: 1048 QAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPK 1107
Query: 437 ----RTTVTRLKSQTEKL-DEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQK 491
RT T +++E + E M D T + ++ L + KL++ E ++
Sbjct: 1108 PGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMSLFLKLQKRVTELEQ 1167
Query: 492 EREATQELIEDLRKELEHLQMYKLDCERPG-RGRSASSGLGEFNARAREVELEHEVKRLK 550
E++ Q+ ++ RKE + L+ + ERP RG E+ + R+ ELE E K+LK
Sbjct: 1168 EKQVMQDELD--RKEEQVLRSKAKEEERPQIRGAEL-----EYESLKRQ-ELESENKKLK 1219
Query: 551 QENYKLR 557
E +LR
Sbjct: 1220 NELNELR 1226
Score = 43.1 bits (100), Expect = 8e-04
Identities = 52/272 (19%), Positives = 104/272 (38%), Gaps = 37/272 (13%)
Query: 374 QLVHRVHELEEMVK---DQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLE 430
QL +V E + K ++ T E E + R +L+ + E ++ RV L+
Sbjct: 931 QLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEE-EAKVATGRVLSLQ 989
Query: 431 EENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLY--------------- 475
EE +LR + + +S+ + ++E R E LK+E L
Sbjct: 990 EEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQA 1049
Query: 476 --------KRMMDKLRQNRLEFQKEREATQELIEDLRK------ELEHLQMYKLDCERPG 521
K+++++ +Q L+ ER Q L+ + + +L+ + +PG
Sbjct: 1050 KEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPKPG 1109
Query: 522 RGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAA 581
R+ S+ ++ E E+ ++ + + ++ +SL L K +
Sbjct: 1110 HKRTDST----HSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMSLFLKLQKRVTEL 1165
Query: 582 QTKAQSLAAEIDTASRDELMEALKEQEEINFR 613
+ + Q + E+D L KE+E R
Sbjct: 1166 EQEKQVMQDELDRKEEQVLRSKAKEEERPQIR 1197
Score = 41.6 bits (96), Expect = 0.002
Identities = 65/312 (20%), Positives = 129/312 (41%), Gaps = 59/312 (18%)
Query: 343 KVSFLEKKVTELEND------SLTN--GDLKSKLKQENTQLVHRVHELEEMVKDQETTAE 394
K+ L++KV E D LTN G S+ ++ + L R+ EE K T
Sbjct: 928 KIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDL-ERLQLSEEEAK-VATGRV 985
Query: 395 QALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEER 454
+L+EE + R+ + EK + + + ++E +L V+ LK + L +E+
Sbjct: 986 LSLQEEIAKLRKDLEQTRSEK----KCIEEHADRYKQETEQL---VSNLKEENTLLKQEK 1038
Query: 455 QRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRK------ELE 508
+ ++ R+ + + + M+ K+++++ +Q L+ ER Q L+ + + +L+
Sbjct: 1039 EALNHRIVQQAKEMTETME--KKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLK 1096
Query: 509 HLQMYKLDCERPGRGRSASSGLGE-----FNARAREVE---------------------- 541
+ +PG R+ S+ F++ E+E
Sbjct: 1097 EEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMSLFL 1156
Query: 542 -LEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDEL 600
L+ V L+QE ++D+ D Q+L E + + + + E ++ R EL
Sbjct: 1157 KLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEE-----RPQIRGAELEYESLKRQEL 1211
Query: 601 -MEALKEQEEIN 611
E K + E+N
Sbjct: 1212 ESENKKLKNELN 1223
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,220,285
Number of Sequences: 37866
Number of extensions: 1204129
Number of successful extensions: 12892
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 441
Number of HSP's successfully gapped in prelim test: 986
Number of HSP's that attempted gapping in prelim test: 5813
Number of HSP's gapped (non-prelim): 4312
length of query: 637
length of database: 18,247,518
effective HSP length: 109
effective length of query: 528
effective length of database: 14,120,124
effective search space: 7455425472
effective search space used: 7455425472
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.