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Search of human proteins with 24430183
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo
sapiens]
(638 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo s... 1236 0.0
gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo s... 1116 0.0
gi|55749696 outer dense fiber of sperm tails 2-like isoform a [H... 195 9e-50
gi|55749708 outer dense fiber of sperm tails 2-like isoform b [H... 162 9e-40
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 108 1e-23
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 107 3e-23
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 107 3e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 107 3e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 104 3e-22
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 100 4e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 100 7e-21
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 99 2e-20
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 99 2e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 97 3e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 97 3e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 97 3e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 97 3e-20
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 94 5e-19
gi|156104908 myosin heavy chain 6 [Homo sapiens] 93 7e-19
gi|16262452 cingulin [Homo sapiens] 93 9e-19
gi|21735548 centrosomal protein 2 [Homo sapiens] 92 1e-18
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 92 1e-18
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 92 2e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 91 4e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 91 4e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 91 4e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 91 4e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 91 4e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 91 4e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 91 4e-18
>gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo
sapiens]
Length = 638
Score = 1236 bits (3199), Expect = 0.0
Identities = 638/638 (100%), Positives = 638/638 (100%)
Query: 1 MSASSSGGSPRFPSCGKNGVTSLTQKKVLRAPCGAPSVTVTKSHKRGMKGDTVNVRRSVR 60
MSASSSGGSPRFPSCGKNGVTSLTQKKVLRAPCGAPSVTVTKSHKRGMKGDTVNVRRSVR
Sbjct: 1 MSASSSGGSPRFPSCGKNGVTSLTQKKVLRAPCGAPSVTVTKSHKRGMKGDTVNVRRSVR 60
Query: 61 VKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKS 120
VKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKS
Sbjct: 61 VKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKS 120
Query: 121 EVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH 180
EVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH
Sbjct: 121 EVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH 180
Query: 181 LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQK 240
LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQK
Sbjct: 181 LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQK 240
Query: 241 LSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVE 300
LSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVE
Sbjct: 241 LSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVE 300
Query: 301 ELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 360
ELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA
Sbjct: 301 ELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 360
Query: 361 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS 420
EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS
Sbjct: 361 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS 420
Query: 421 TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 480
TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA
Sbjct: 421 TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 480
Query: 481 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 540
EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE
Sbjct: 481 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 540
Query: 541 VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 600
VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG
Sbjct: 541 VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 600
Query: 601 YERKNIDLTAIISDLRSRVRDWQKGSHELTRAGARIPR 638
YERKNIDLTAIISDLRSRVRDWQKGSHELTRAGARIPR
Sbjct: 601 YERKNIDLTAIISDLRSRVRDWQKGSHELTRAGARIPR 638
>gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo
sapiens]
Length = 805
Score = 1116 bits (2886), Expect = 0.0
Identities = 580/585 (99%), Positives = 582/585 (99%), Gaps = 1/585 (0%)
Query: 36 PSVTVT-KSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDD 94
PS T + KSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDD
Sbjct: 30 PSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDD 89
Query: 95 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 154
DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE
Sbjct: 90 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 149
Query: 155 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG 214
HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG
Sbjct: 150 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG 209
Query: 215 KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL 274
KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL
Sbjct: 210 KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL 269
Query: 275 LKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQL 334
LKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQL
Sbjct: 270 LKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQL 329
Query: 335 RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA 394
RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA
Sbjct: 330 RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA 389
Query: 395 EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLV 454
EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLV
Sbjct: 390 EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLV 449
Query: 455 NQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLK 514
NQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLK
Sbjct: 450 NQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLK 509
Query: 515 ASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL 574
ASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL
Sbjct: 510 ASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL 569
Query: 575 ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRV 619
ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSR+
Sbjct: 570 ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRI 614
>gi|55749696 outer dense fiber of sperm tails 2-like isoform a [Homo
sapiens]
Length = 644
Score = 195 bits (496), Expect = 9e-50
Identities = 128/469 (27%), Positives = 238/469 (50%), Gaps = 8/469 (1%)
Query: 161 RHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK 220
+ ++ R E + L K+ + EK L + L EAE+ + + KDTI K+ E
Sbjct: 24 KEDLPRCTSESHLSCL-KQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
Query: 221 QMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE 280
++ QKE+L+++L TF+ L LLR++ K+ + L LL+ L +
Sbjct: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSM---LLENLTD 139
Query: 281 ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAE 340
+SE L + +K+ ++EL Q EKA A+ S+S++ + LQ Q+ +EAE
Sbjct: 140 NESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAE 199
Query: 341 NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEY 400
N +L +K+LE + + + +K+ + +LKKA + K+R +
Sbjct: 200 NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA 259
Query: 401 AEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL 460
E+L Q+ D++ ++E +S +W+S Y ++V EK +LE++I + ++ +L+ + +
Sbjct: 260 IEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM 319
Query: 461 EEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNY 520
E+ + + ++ ++H E LEN +LK + A ++D++ E+ +L+ K
Sbjct: 320 EDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQ 379
Query: 521 EGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQL 580
+ +I+ YK+QV K + A+ V ++ E +N + NK +E R Q +S L +L+++
Sbjct: 380 KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERV 439
Query: 581 PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHEL 629
D L E +L ECQ+ LQ + K D I +L+ +V G+H L
Sbjct: 440 CDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQV----DGNHNL 484
Score = 59.7 bits (143), Expect = 8e-09
Identities = 105/571 (18%), Positives = 233/571 (40%), Gaps = 52/571 (9%)
Query: 41 TKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCK 100
++SH +K D +N + + K E+ S E L+ + + + +++
Sbjct: 32 SESHLSCLKQDILNEKTELEATLKEA----ELVTHSVELLLPLFKDTIEKINFENANLSA 87
Query: 101 MN-RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHE-LAETEHENT 158
+N + ++ + L+ + KS VK+ E + KR ++ + L + E L + E ENT
Sbjct: 88 LNLKISEQKEILIKELDTFKS-VKLAL-EHLLRKRDYKQTGDNLSSMLLENLTDNESENT 145
Query: 159 VLRHNIER-----------MKEEKDFTILQKKHLQQEK---ECLMSKLVEAEMDGAAAAK 204
L+ + + EK T+ + Q K E L ++ + E + +
Sbjct: 146 NLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKE 205
Query: 205 QVMALKDTIGKLKTEKQMTCTD---INTLTRQKELLL--------QKLSTFEETNRTLRD 253
V +L+ I K + +M + + +RQK + L Q+L F L
Sbjct: 206 YVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTS 265
Query: 254 LLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQA 313
+R+Q K + A + EK L + ++ K++ LL++++ +
Sbjct: 266 QIRDQEAK--LSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG 323
Query: 314 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELK 373
K + E + ++ S E EN L ++ L+ + K EV ++ +L EL
Sbjct: 324 KNSCE----------EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL- 372
Query: 374 QKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-TLESWRSRYNQV 432
Q+ ++ +++L + + Q ++ +++ E + L K+ + + + +E R +
Sbjct: 373 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 432
Query: 433 VKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYS-----AFKL 487
+KE + + R+ + Q + K + ++ E + ++ + +
Sbjct: 433 LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEE 492
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
EN ++ ++ KL Q E ++L+ + N E + + + + E +A QLE
Sbjct: 493 ENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEA 552
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+E + E +++ + Q ++ DL+
Sbjct: 553 ALEEGRQKVAEEIEKMSSRESALQIKILDLE 583
>gi|55749708 outer dense fiber of sperm tails 2-like isoform b [Homo
sapiens]
Length = 513
Score = 162 bits (410), Expect = 9e-40
Identities = 98/356 (27%), Positives = 186/356 (52%), Gaps = 4/356 (1%)
Query: 274 LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQ 333
LL+ L + +SE L + +K+ ++EL Q EKA A+ S+S++ + LQ Q
Sbjct: 2 LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
Query: 334 LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKER 393
+ +EAEN +L +K+LE + + + +K+ + +LKKA + K+R
Sbjct: 62 IHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQR 121
Query: 394 AEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDL 453
+ E+L Q+ D++ ++E +S +W+S Y ++V EK +LE++I + ++ +L
Sbjct: 122 LDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
Query: 454 VNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQL 513
+ + +E+ + + ++ ++H E LEN +LK + A ++D++ E+ +L
Sbjct: 182 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
Query: 514 KASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ 573
+ K + +I+ YK+QV K + A+ V ++ E +N + NK +E R Q +S
Sbjct: 242 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
Query: 574 LADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHEL 629
L +L+++ D L E +L ECQ+ LQ + K D I +L+ +V G+H L
Sbjct: 302 LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQV----DGNHNL 353
Score = 58.2 bits (139), Expect = 2e-08
Identities = 99/465 (21%), Positives = 182/465 (39%), Gaps = 64/465 (13%)
Query: 45 KRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRY 104
K + TV ++++ +V + H + EKL S +R + + S +
Sbjct: 101 KEASRQKTVALKKASKVYKQRLDHFTG----AIEKLTSQIRDQEAKLSETISASNAWKSH 156
Query: 105 DKKIDSLMNAVGCLKSEVKMQKGERQMA------KRFLEERKEELEEVAHELAETEHENT 158
+KI + + EV+++ ++Q+ K+ + K EE+ ++ E+EN
Sbjct: 157 YEKI-----VIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENE 211
Query: 159 VLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKT 218
L N+E K + L+ + + E E +S+L E E K KT
Sbjct: 212 TL--NLENTKLKTTLAALKDEVVSVENE--LSELQEVEK-----------------KQKT 250
Query: 219 EKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRL 278
+M T + L E++ + N Q K ++ + + +G + L
Sbjct: 251 LIEMYKTQVQKLQEAAEIVKSRCENLLHKN--------NQITKTKNKNVEKMRGQMESHL 302
Query: 279 AEADSEKARLLLLLQDKDKEVEELLQEIQCEKA----QAKTASELSKSMESMRGHLQAQL 334
E + R+ L ++ + E + +QC K Q T EL ++ H
Sbjct: 303 KELE----RVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDG--NHNLLTK 356
Query: 335 RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA 394
S E EN + ++ +NL++ Q AE KEL++K +E LK + KE++
Sbjct: 357 LSLEEENCLIQLKCENLQQKLEQMDAE-------NKELEKKLANQEECLKHSNLKFKEKS 409
Query: 395 EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLV 454
+ A QL L + VAE +E SR + + + DLE E+ N+ LV
Sbjct: 410 AEYTALARQLEAALEEGRQKVAE---EIEKMSSRESALQIKILDLETELRKKNEEQNQLV 466
Query: 455 NQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPM 499
+ + + + L + + + K + LK S+ M
Sbjct: 467 CKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTM 511
Score = 55.1 bits (131), Expect = 2e-07
Identities = 84/460 (18%), Positives = 185/460 (40%), Gaps = 44/460 (9%)
Query: 150 LAETEHENTVLRHNIER-----------MKEEKDFTILQKKHLQQEK---ECLMSKLVEA 195
L + E ENT L+ + + EK T+ + Q K E L ++ +
Sbjct: 6 LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKR 65
Query: 196 EMDGAAAAKQVMALKDTIGKLKTEKQMTCTD---INTLTRQKELLL--------QKLSTF 244
E + + V +L+ I K + +M + + +RQK + L Q+L F
Sbjct: 66 EAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHF 125
Query: 245 EETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQ 304
L +R+Q K + A + EK L + ++ K++ LL+
Sbjct: 126 TGAIEKLTSQIRDQEAK--LSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLE 183
Query: 305 EIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEA 364
+++ + K + E + ++ S E EN L ++ L+ + K EV +
Sbjct: 184 DLKKMEDHGKNSCE----------EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVS 233
Query: 365 IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-TLE 423
+ +L EL Q+ ++ +++L + + Q ++ +++ E + L K+ + + + +E
Sbjct: 234 VENELSEL-QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE 292
Query: 424 SWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYS 483
R + +KE + + R+ + Q + K + ++ E + ++
Sbjct: 293 KMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHN 352
Query: 484 -----AFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 538
+ + EN ++ ++ KL Q E ++L+ + N E + + + + E
Sbjct: 353 LLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEY 412
Query: 539 DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+A QLE +E + E +++ + Q ++ DL+
Sbjct: 413 TALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLE 452
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 108 bits (271), Expect = 1e-23
Identities = 132/604 (21%), Positives = 268/604 (44%), Gaps = 88/604 (14%)
Query: 78 EKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE 137
E+L + ++ DL + ++ I+ L G + +E K Q E LE
Sbjct: 325 ERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET------LE 378
Query: 138 ERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEM 197
++EE+ ++ + + + LR E+ E F L+K +K + ++AEM
Sbjct: 379 MKEEEIAQLRSRIKQMTTQGEELREQKEK-SERAAFEELEKALSTAQKTEEARRKLKAEM 437
Query: 198 DGA------AAAKQVMALKDTIGKLKTE-----KQMTCTDI--------NTLTRQKELLL 238
D + ++ ++L+ + ++K E K+ + I L R+++ L
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELT 497
Query: 239 QKLST----FEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
+KL T F+E + + + ++ K E+ EQQ +L L E + +K +L ++
Sbjct: 498 KKLQTREREFQEQMKVALEKSQSEYLKISQEK--EQQESLA--LEELELQKKAILTESEN 553
Query: 295 KDKEVEELLQE-----IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK 349
K +++++ + ++ E + K+ E + + HL+A+ K N + + ++
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE---KNKHNKEITVMVE 610
Query: 350 NLERSGNQHKAEVEAIM--------EQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYA 401
+HK E+E++ E+L+ LKQ+ + E L++ +KE K +E
Sbjct: 611 -------KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII 663
Query: 402 EQLHVQ-LADKDLYVAEALST-LESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
Q H++ + +K L + T LES S ++V+K + LE E+ VL D+ TD + Q+
Sbjct: 664 FQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ-TDKMKQE-- 720
Query: 460 LEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKN 519
LE KM E ++ H Q S K ++ + ++D++NQ L +++ +K
Sbjct: 721 LEAKMDEQKN------HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
Query: 520 YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ- 578
++ ++N ++ + ++ E + +A+L+ + + E K E Q Q +L DL+
Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833
Query: 579 --------------QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL----RSRVR 620
Q D+ +A + QD +Q E++N ++ + L S++
Sbjct: 834 ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893
Query: 621 DWQK 624
D K
Sbjct: 894 DGNK 897
Score = 85.9 bits (211), Expect = 1e-16
Identities = 110/518 (21%), Positives = 227/518 (43%), Gaps = 57/518 (11%)
Query: 102 NRYDKKIDSLMNAVGCLKSEVKMQKG-----ERQMAKRFLEERKEELEEVAHELAET--E 154
N+++K+I ++ +K Q+ + Q+ K+ + E+L E + ET +
Sbjct: 599 NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658
Query: 155 HENTVLRHNIERMKEEKDFTILQKKHLQQ-EKECLMSKLVEAEMDGAAAAKQVMALKDTI 213
+ + + +IE M E+ L+K ++Q E E L S+L E +++ LKD
Sbjct: 659 DKEIIFQAHIEEMNEKT----LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
Query: 214 GKLKTEKQMTCTDINTLTRQK--ELLLQKLSTFEETNRTLRDLLREQHC--KEDSERLME 269
K+K E + + +Q+ ++ + + + T + L+D + + KE + L E
Sbjct: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
Query: 270 QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGH 329
Q A ++ L EAD +++ + E+++ ++ ++ E +K+ E
Sbjct: 775 HQ-AHVENL-EADIKRS---------EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
Query: 330 LQAQLRSKEAENSRLCMQIKNLERSGNQ-------HKAEVEAIMEQLKELKQKGDRDKES 382
LQ +L E E L Q+ +E HK +V+ +M+QL++ + ++ +S
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 383 LKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELE 442
L + ++ E K +E +Q+ L +K+ + L E + + ++ E
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQI---LVEKENMI---LQMREGQKKEIEILTQKLSAKEDS 937
Query: 443 IIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA-FKLENERLKASFAPMED 501
I +LN+ Q+ EK+++ + E L ++ + A K E E + E
Sbjct: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997
Query: 502 KLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK 561
+ N LE+ Q N G+ D +RLE + Q E+ + ++ + E+N
Sbjct: 998 QFNAKMLEMAQ-----ANSAGISD------AVSRLETN----QKEQIESLTEVHRRELND 1042
Query: 562 EIEAARRQFQSQLADLQQLPDI-LKITEAKLAECQDQL 598
I ++ Q +LQ++ +I L+ E ++AE + ++
Sbjct: 1043 VISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI 1080
Score = 75.9 bits (185), Expect = 1e-13
Identities = 118/541 (21%), Positives = 213/541 (39%), Gaps = 78/541 (14%)
Query: 133 KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMS-- 190
K EE K ++ E+ +L T+ E L+ + E+ + + L+ K L +E +
Sbjct: 1161 KMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDIC 1220
Query: 191 -KLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 249
K EA ++ A +++ + + + C + T+ KE LL K T E
Sbjct: 1221 CKKTEALLE--AKTNELINISSSKTNAILSRISHCQ--HRTTKVKEALLIKTCTVSELEA 1276
Query: 250 TLRDLLREQHC----------------------KEDSERLMEQQGALLKR---LAEADSE 284
LR L EQ+ K D E L+ ++ AL K +A SE
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Query: 285 KARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQLRSKEAE 340
K + L+ KE+ E + + K + K S LSK + + LQ + E E
Sbjct: 1337 KESCITQLK---KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKE 1393
Query: 341 NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEY 400
+ I +L + ++ K E +++Q+++L K D + A+ + + K E+
Sbjct: 1394 AA-----ISSLRKQYDEEKCE---LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 401 AEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL 460
++ + V E LE + ++ L+ E+ N R L + +
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 461 EEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNY 520
+ KM + +L L QTA +ED + Q +E++ L +KNY
Sbjct: 1506 KSKMEKKESNLETELKSQTAR--------------IMELEDHITQKTIEIESLNEVLKNY 1551
Query: 521 EGMID-NYKSQVMKTR-------------LEADEVAAQLERCDKENKILKDEMNKEIEAA 566
D +K V K + EA+E LE K + KE+E
Sbjct: 1552 NQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHV 1611
Query: 567 RRQFQSQLADLQQLPDILKI-TEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
+S+ +L+ L D L+ + AKLAE + + + ++ ++S + + ++KG
Sbjct: 1612 NLSVKSKEEELKALEDRLESESAAKLAELKRKAE--QKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 626 S 626
+
Sbjct: 1670 T 1670
Score = 73.9 bits (180), Expect = 4e-13
Identities = 132/607 (21%), Positives = 258/607 (42%), Gaps = 88/607 (14%)
Query: 78 EKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE 137
E + + +L E D+ ++ ++KI +L N V +K+E++ +K E + ++
Sbjct: 1561 ELVQKLQHFQELGEEKDN----RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616
Query: 138 ERKEELE--------EVAHELAE----TEHENTVLRHNIERMKEEKD----------FTI 175
++EEL+ E A +LAE E + ++ + EEK+ +
Sbjct: 1617 SKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSE 1676
Query: 176 LQKKHLQQEKE--CLMSKLVEAEMDGA------AAAKQVMAL-----KDTIGKLKTEKQM 222
L K ++E+E L KL E + +AK V A D+ G ++ +
Sbjct: 1677 LNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE 1736
Query: 223 TCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD 282
+ + +KE LLQ++ +E + +R Q+ ERL++ + A K+ E
Sbjct: 1737 KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY----QERLIKLEHAEAKQ-HEDQ 1791
Query: 283 SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENS 342
S L L++K+K+ ++ + EK K + +++E++ +Q L+ KE
Sbjct: 1792 SMIGHLQEELEEKNKKYSLIVAQ-HVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQ 1850
Query: 343 RLCMQIKNLE----RSGNQHKAEVEAI---MEQLKELKQKGDRDKES------------- 382
L +IK L+ R H+ E+E + E+L+ L+Q R+K +
Sbjct: 1851 ILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 383 ------LKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEK 436
L + AQ E AE+ +L + + + + L L + +++K++
Sbjct: 1911 HLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKE 1970
Query: 437 GDLELEIIVLNDRVTDLVNQQQTLEEKMRE------DRDSLVERLHRQTAEYSAFKLENE 490
D E E + ++ + TL++ MRE ++ +E ++T A ++E E
Sbjct: 1971 YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETIN-KAQEVEAE 2029
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
L++ L + + LK + K YE ++D + ++ + ++ QLE K
Sbjct: 2030 LLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEM---TAKVRDLQTQLEELQK 2086
Query: 551 --ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAE----CQDQLQGYERK 604
+ K+ ++E + Q+QLA L K+ E + E +D+L+ YE K
Sbjct: 2087 KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE-K 2145
Query: 605 NIDLTAI 611
N+ T +
Sbjct: 2146 NVYATTV 2152
Score = 72.0 bits (175), Expect = 2e-12
Identities = 110/564 (19%), Positives = 223/564 (39%), Gaps = 92/564 (16%)
Query: 128 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIE-RMKEEKDFTILQKKHLQQEKE 186
+ M + E +K+E+E + +L+ E +L E + K ++ K+ ++ +E
Sbjct: 909 KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE 968
Query: 187 CLMSKLVEAEMDGAAAAKQVMALKDTIGKL-KTEKQMTCTDINTLTRQKELLLQKLSTFE 245
L KL++ E AK L++T +L + EKQ + + +S E
Sbjct: 969 TLKKKLLDQE------AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE 1022
Query: 246 ETNRTLRDLLREQHCKEDS------ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEV 299
+ + L E H +E + E+ + QQ L+ + E + LQ+K++EV
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE---------IQLQEKEQEV 1073
Query: 300 EELLQEIQ---CEKAQAKTA----SELSKSMESMRGHLQAQLRSKEA-------ENSRLC 345
EL Q+I CEK + E ++ LQ QL+ K A + ++L
Sbjct: 1074 AELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK 1133
Query: 346 MQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKK-------------AIRAQKE 392
++ LE N+ E + EQL ELK + DK + + ++++ E
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193
Query: 393 RAEKSEE--------YAEQLHVQL-----ADKDLYVAEALSTLESWRSRYNQVV------ 433
++ KS E +E+L +QL + L A+ + S+ N ++
Sbjct: 1194 KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253
Query: 434 -----KEKGDLELEIIVLND---RVTDLVNQQQTLEEKMREDRDSLVER---LHRQTAEY 482
K K L ++ +++ ++ L +Q TL ++ L E+ + A+
Sbjct: 1254 QHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADI 1313
Query: 483 SAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVA 542
+ E E L+ + ++ + QLK + + K ++ + ++E ++
Sbjct: 1314 ESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLS 1373
Query: 543 AQLE--RCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 600
QL +N I E I + R+Q+ + +L ++ + ++
Sbjct: 1374 KQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD----------QVQDLSFKVDT 1423
Query: 601 YERKNIDLTAIISDLRSRVRDWQK 624
++ I + D ++ +W+K
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKK 1447
Score = 65.5 bits (158), Expect = 1e-10
Identities = 110/541 (20%), Positives = 233/541 (43%), Gaps = 85/541 (15%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
LK E+ + K L+E+K E+ ++ +L + N L+++I ++E + L+
Sbjct: 1344 LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL---NVQLQNSISLSEKEAAISSLR 1400
Query: 178 KKHLQQEKECLMS------KLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTD----I 227
K++ +++ E L K+ + +A +QV + + K + Q T +
Sbjct: 1401 KQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 228 NTLTRQKELLLQKLSTFEETNRTLRDLLREQH---------------------------C 260
L Q EL ++ +E L++ L +Q+
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 261 KEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQC-------EKAQA 313
K + R+ME + + ++ E +S L Q KD E +EL+Q++Q + +
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 314 KTASELSKSMESMRGHLQAQL--RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 371
K A E ++E+ ++A+L + KE E+ L ++ K E + + E E+ +L E
Sbjct: 1581 KEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESES-AAKLAE 1639
Query: 372 LKQKGDRDKESLKKAIRAQKERAEK-----SEEYAEQLHVQLADKDLYV---AEALSTLE 423
LK+K ++ ++KK + +Q E E+ +E + +L+ +L +++ V E L ++E
Sbjct: 1640 LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Query: 424 SWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMR------EDRDSLVERLHR 477
S S+ ++ + + + Q+T EEK+ +++ L++R+ +
Sbjct: 1700 S--SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757
Query: 478 QTAEYSAFKLE-----NERL----KASFAPMEDKLNQAHLEVQQLKASVKNYEGMI-DNY 527
+ E + E ERL A ED+ HL+ ++L+ K Y ++ +
Sbjct: 1758 EKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ-EELEEKNKKYSLIVAQHV 1816
Query: 528 KSQVMKTRLEA--------DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQ 579
+ + K ++A D+V L+ + +IL+ ++ + RQ + ++++
Sbjct: 1817 EKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 580 L 580
L
Sbjct: 1877 L 1877
Score = 62.8 bits (151), Expect = 9e-10
Identities = 112/541 (20%), Positives = 217/541 (40%), Gaps = 101/541 (18%)
Query: 87 SDLSTEDDDS-GHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEE 145
SD+ +E +D G+ ++ I L L S + + E A + L+ K++L+
Sbjct: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSS-YRGKYSELVTAYQMLQREKKKLQG 176
Query: 146 VAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQ 205
+ ++ ++ LR I ++EE KKHLQ+E + + L E + + Q
Sbjct: 177 IL-----SQSQDKSLRR-IAELREELQMDQQAKKHLQEEFD---ASLEEKDQYISVLQTQ 227
Query: 206 VMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
V LK + R + + L + +E++ + D E
Sbjct: 228 VSLLKQRL------------------RNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGE 269
Query: 266 RLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMES 325
++E D + L LQ + K E LL+ + ++++S
Sbjct: 270 PVVE------------DGTSVKTLETLQQRVKRQENLLKRCK-------------ETIQS 304
Query: 326 MRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKK 385
+ KEA +L +++ LE+ + H AE ++ QL++ K
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK------------ 352
Query: 386 AIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIV 445
EQL DK + +AE + + ++ ++ K E EI
Sbjct: 353 -------------NLIEQLE---QDKGMVIAET-------KRQMHETLEMK---EEEIAQ 386
Query: 446 LNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQ 505
L R+ + Q + L E+ + + E L + A +A K E R K A M++++
Sbjct: 387 LRSRIKQMTTQGEELREQKEKSERAAFEELEK--ALSTAQKTEEARRKLK-AEMDEQIKT 443
Query: 506 AHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEA 565
++ + S++ + VMK E +++A + +KE + E+ K+++
Sbjct: 444 IEKTSEEERISLQQELSRVKQEVVDVMKKSSE-EQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 566 ARRQFQSQL--ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQ 623
R+FQ Q+ A + + LKI++ K E Q+ L E + AI+++ +++RD Q
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEK--EQQESL-ALEELELQKKAILTESENKLRDLQ 559
Query: 624 K 624
+
Sbjct: 560 Q 560
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 107 bits (268), Expect = 3e-23
Identities = 148/679 (21%), Positives = 303/679 (44%), Gaps = 92/679 (13%)
Query: 30 RAPCGAPSVTVTKSHKR------GMKGDTVNVRRSVRVKTKNPPHC----------LEIT 73
++PCG+P + T+S + K +R+ + KT+ C L+
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRL 291
Query: 74 PPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDK------KIDSLMNAVGCLKSEVKMQKG 127
+ L+S R + + ++ D+ K R DK + ++ + K+ V+ K
Sbjct: 292 QQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
Query: 128 ERQM---AKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQE 184
+ Q+ K LE++ E + +L E E EN L+ + M+ E+D + +K +++
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERD---MDRKKIEE- 407
Query: 185 KECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ-KELLLQKLST 243
LM + + EM + + + L + ++ +++ +L + EL +L
Sbjct: 408 ---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 244 FEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 303
E N++L + E DS +E + + ++ + + ++ + +L+++ + ++ L
Sbjct: 465 LEMENQSLTKTVEELRTTVDS---VEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
Query: 304 QEIQ-CEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNL-ERSGNQHKAE 361
Q Q K K ++L K++E++R + + Q++ E EN L + +L +RS +A
Sbjct: 522 QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR 581
Query: 362 VEAI-------MEQLKELKQKGDR---DKESLKKAIRAQKERAEKSEEYAEQLHVQLADK 411
V+ I E +KE K + +K +KK + KE+ E++EE +LH L +
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKE 640
Query: 412 DLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN---DRVTDLVNQQQTLE-EKMRED 467
+ + + ++ L+ + + +E +LE E L D +L Q ++LE E + D
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 468 RDSL-----VERLHRQTAEYSAFKLEN--------------ERLKASFAP---MEDKLNQ 505
++L VE L + + + +LEN E LKASF +E
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 506 AHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEV----------AAQLERCDKENKIL 555
+E Q+L+ +++N I +S++ +E + + +LE+ +KENK L
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 556 KDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLT---AII 612
+ E ++E ++Q + + L+Q +I T L E ++ E++N L+ I
Sbjct: 821 EQE-TSQLEKDKKQLEKENKRLRQQAEIKDTT---LEENNVKIGNLEKENKTLSKEIGIY 876
Query: 613 SDLRSRVRDWQKGSHELTR 631
+ R+++ +K + EL +
Sbjct: 877 KESCVRLKELEKENKELVK 895
Score = 80.5 bits (197), Expect = 4e-15
Identities = 132/613 (21%), Positives = 248/613 (40%), Gaps = 101/613 (16%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
+ + +++ +N ++I +E L + S L S ++ +K+
Sbjct: 534 EKAQLEKTIETLRENSERQIKILEQENEHLNQTV--SSLRQRSQISAEARVKDIEKENKI 591
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLE---ERKEELEEVAHELAETEHENTVLRHNIERM 167
L ++ S++ + E++ K+ LE E+ E EE+ +EL E EN +L+ I +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 168 KEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKT-EKQMTCTD 226
K T + + L+QE E E + K + + K+ +L++ EK+ + D
Sbjct: 652 K----ITCEKIEALEQENS-------ELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 227 INTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEA----- 281
L ++ + K ++ + L + E KE ++ +E A K+
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 282 --DSEKARLLLLLQDKDKEVEEL---LQEIQCE-----------KAQAKTASEL---SKS 322
D E RL L++ +K++++L LQ+++ E K +K +L +KS
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQ--------------IKNLERSGNQHKAEVEAIMEQ 368
+E L+ + E EN RL Q I NLE+ E+ E
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 369 LKELKQKGDRDKESLKKAIRAQKERAEKSEE-YAEQLHVQLADKDLYVAEALSTLESWRS 427
LK+ +KE +K+A K E+ +E+L Q + DL
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL-------------- 925
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
EK ELE I LN L++ +Q+ ++ + +S +E +++ E +
Sbjct: 926 -------EKLTHELEKIGLNKE--RLLHDEQSTDDSRYKLLESKLESTLKKSLE-----I 971
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM------------KTR 535
+ E++ A A +E+ N Q+LK KNYE + + M K
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1031
Query: 536 LEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E+ E +L + K+ I + N ++A ++ ++QL L+ + L +A++ Q
Sbjct: 1032 RESQETTRELLKV-KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL---QAQILALQ 1087
Query: 596 DQLQGYERKNIDL 608
Q + +N L
Sbjct: 1088 RQTVSLQEQNTTL 1100
Score = 62.4 bits (150), Expect = 1e-09
Identities = 122/576 (21%), Positives = 232/576 (40%), Gaps = 87/576 (15%)
Query: 42 KSHKRGMKGDTVNVRRSV---------RVKTKNPPHCLEITPPSSEKL-VSVMRLSDLST 91
K +K +K T++++ V ++KT+ + LE EK+ ++ RL
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 92 EDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHEL- 150
DDS RY K ++S + + LK +++++ + + LEE +++ EL
Sbjct: 948 STDDS------RY-KLLESKLEST--LKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 998
Query: 151 -AETEHENTVLRHNIERMKEEK-----DFTILQKKHLQQEKECLMSK--LVEAEMDGAAA 202
+ +E R + ERM + + +++ + +E L K L+E E + A
Sbjct: 999 TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058
Query: 203 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE 262
+ ALK + +L+T+ I L RQ L ++ +T + N L+ +
Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ--VENSTLNS 1116
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQD---------KDKEVEELLQEIQCEKAQA 313
S LM Q LL + + ++E ++ +D KD E ELL E Q + ++
Sbjct: 1117 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1176
Query: 314 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEV----------E 363
+ +++S +L+ + R E ++L Q LE K E E
Sbjct: 1177 LISKH--GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1234
Query: 364 AIMEQLKELKQKGDR-----------------DKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ + K+L + DR D ++LK + K + E +L
Sbjct: 1235 TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1294
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
Q D+ T ++ + + KG+LE E L D++ L+ Q +TL E+ E
Sbjct: 1295 QYQQLDI-------TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNME 1347
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASF---------APMEDKLNQAHLEVQQLKASV 517
+D + + + + + E+L+ +P + N L++++L S
Sbjct: 1348 SKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSK 1407
Query: 518 KNYEGMIDNYKSQVM-KTRLEADEVAAQLERCDKEN 552
K+ + KS + TR ++ E QL D ++
Sbjct: 1408 KDINR--ERQKSLTLTPTRSDSSEGFLQLPHQDSQD 1441
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/409 (22%), Positives = 168/409 (41%), Gaps = 69/409 (16%)
Query: 261 KEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELS 320
+ED E L++ LKRL + E + ++ L ++ + L AQ+ S
Sbjct: 183 QEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPH--ASSSAQSPCGSPGM 240
Query: 321 KSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKG---- 376
K ES R HL +L +A+ RL +++ K E+E + +LK L+Q+
Sbjct: 241 KRTES-RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 377 ----------DRDKESLKKAIRAQKERAEKSEEYAEQLH--------VQLADKDLYVAEA 418
D +KA+R K +E S Y E+LH V+ +D V
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVS-RYKERLHDIEFYKARVEELKEDNQVLLE 358
Query: 419 LST-----LESWRSRYN----------QVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEK 463
T LE R+R + Q+ + D+E+E + ++ +L+ + TLE
Sbjct: 359 TKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 464 MREDRDSLVERLH--------RQTAEYSAFKLE------NERLKASFAPMEDKLNQAHLE 509
++ D E LH +T+E S + NE + +E +
Sbjct: 419 QKQSMD---ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 510 VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
V++L+ +V + EG S+++K E +R K+ +IL++E+ +E ++ +
Sbjct: 476 VEELRTTVDSVEG----NASKILKMEKEN-------QRLSKKVEILENEIVQEKQSLQNC 524
Query: 570 FQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSR 618
+++ + K E + Q++ E++N L +S LR R
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 107 bits (268), Expect = 3e-23
Identities = 148/679 (21%), Positives = 303/679 (44%), Gaps = 92/679 (13%)
Query: 30 RAPCGAPSVTVTKSHKR------GMKGDTVNVRRSVRVKTKNPPHC----------LEIT 73
++PCG+P + T+S + K +R+ + KT+ C L+
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRL 291
Query: 74 PPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDK------KIDSLMNAVGCLKSEVKMQKG 127
+ L+S R + + ++ D+ K R DK + ++ + K+ V+ K
Sbjct: 292 QQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
Query: 128 ERQM---AKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQE 184
+ Q+ K LE++ E + +L E E EN L+ + M+ E+D + +K +++
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERD---MDRKKIEE- 407
Query: 185 KECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ-KELLLQKLST 243
LM + + EM + + + L + ++ +++ +L + EL +L
Sbjct: 408 ---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 244 FEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 303
E N++L + E DS +E + + ++ + + ++ + +L+++ + ++ L
Sbjct: 465 LEMENQSLTKTVEELRTTVDS---VEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
Query: 304 QEIQ-CEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNL-ERSGNQHKAE 361
Q Q K K ++L K++E++R + + Q++ E EN L + +L +RS +A
Sbjct: 522 QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR 581
Query: 362 VEAI-------MEQLKELKQKGDR---DKESLKKAIRAQKERAEKSEEYAEQLHVQLADK 411
V+ I E +KE K + +K +KK + KE+ E++EE +LH L +
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKE 640
Query: 412 DLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN---DRVTDLVNQQQTLE-EKMRED 467
+ + + ++ L+ + + +E +LE E L D +L Q ++LE E + D
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 468 RDSL-----VERLHRQTAEYSAFKLEN--------------ERLKASFAP---MEDKLNQ 505
++L VE L + + + +LEN E LKASF +E
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 506 AHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEV----------AAQLERCDKENKIL 555
+E Q+L+ +++N I +S++ +E + + +LE+ +KENK L
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 556 KDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLT---AII 612
+ E ++E ++Q + + L+Q +I T L E ++ E++N L+ I
Sbjct: 821 EQE-TSQLEKDKKQLEKENKRLRQQAEIKDTT---LEENNVKIGNLEKENKTLSKEIGIY 876
Query: 613 SDLRSRVRDWQKGSHELTR 631
+ R+++ +K + EL +
Sbjct: 877 KESCVRLKELEKENKELVK 895
Score = 82.4 bits (202), Expect = 1e-15
Identities = 134/613 (21%), Positives = 246/613 (40%), Gaps = 102/613 (16%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
+ + +++ +N ++I +E L + S L S ++ +K+
Sbjct: 534 EKAQLEKTIETLRENSERQIKILEQENEHLNQTV--SSLRQRSQISAEARVKDIEKENKI 591
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLE---ERKEELEEVAHELAETEHENTVLRHNIERM 167
L ++ S++ + E++ K+ LE E+ E EE+ +EL E EN +L+ I +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 168 KEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKT-EKQMTCTD 226
K T + + L+QE E E + K + + K+ +L++ EK+ + D
Sbjct: 652 K----ITCEKIEALEQENS-------ELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 227 INTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEA----- 281
L ++ + K ++ + L + E KE ++ +E A K+
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 282 --DSEKARLLLLLQDKDKEVEEL---LQEIQCE-----------KAQAKTASEL---SKS 322
D E RL L++ +K++++L LQ+++ E K +K +L +KS
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQ--------------IKNLERSGNQHKAEVEAIMEQ 368
+E L+ + E EN RL Q I NLE+ E+ E
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 369 LKELKQKGDRDKESLKKAIRAQKERAEKSEE-YAEQLHVQLADKDLYVAEALSTLESWRS 427
LK+ +KE +K+A K E+ +E+L Q + DL
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL-------------- 925
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
EK ELE I LN ++ +E+ +DR L+E T + S ++
Sbjct: 926 -------EKLTHELEKIGLN-------KERLLHDEQSTDDRYKLLESKLESTLKKS-LEI 970
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM------------KTR 535
+ E++ A A +E+ N Q+LK KNYE + + M K
Sbjct: 971 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1030
Query: 536 LEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E+ E +L + K+ I + N ++A ++ ++QL L+ + L +A++ Q
Sbjct: 1031 RESQETTRELLKV-KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL---QAQILALQ 1086
Query: 596 DQLQGYERKNIDL 608
Q + +N L
Sbjct: 1087 RQTVSLQEQNTTL 1099
Score = 80.1 bits (196), Expect = 6e-15
Identities = 115/527 (21%), Positives = 227/527 (43%), Gaps = 93/527 (17%)
Query: 77 SEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEV----KMQKGERQMA 132
+++L + D + E+++ K+ +K+ +L +G K +++K +++
Sbjct: 838 NKRLRQQAEIKDTTLEENN---VKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 133 KRF-------------LEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKK 179
KR L K + +++ ++L + HE + N ER+ ++ T + K
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYK 954
Query: 180 HLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQ 239
L+ + E + K +E + + AA + + T + L Q
Sbjct: 955 LLESKLESTLKKSLEIKEEKIAALE--------------------ARLEESTNYNQQLRQ 994
Query: 240 KLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALL---KRLAEADSEKARLLLLLQDKD 296
+L T ++ L+ ++D ER+++ + + E R LL ++D+
Sbjct: 995 ELKTVKKNYEALKQ-------RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047
Query: 297 KEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLR-------SKEAENSRLCMQIK 349
EVE +Q EK KT K +E+ +LQAQ+ S + +N+ L Q
Sbjct: 1048 IEVERNNATLQAEKQALKTQ---LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104
Query: 350 NLERSGNQHKAEVEAIMEQLKEL---KQKGDRDKESL---KKAIRAQKERAEKSEEYAEQ 403
L+ + ++ ++M Q +L + + + ES+ ++ +++ + K E E
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL 1164
Query: 404 LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLE-- 461
LH + A S ES S++ + +LE+E L DR L+ Q+ LE
Sbjct: 1165 LHERQA----------SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL 1214
Query: 462 EKMR--EDRDSLVERLHRQT--AEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASV 517
EKM E L+E + +T AEY EN+RL ++ +Q E + L+
Sbjct: 1215 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY-------SQLLKETEVLQTDH 1267
Query: 518 KNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIE 564
KN + +++N S++ +TRLEA+ ++L+ ++ I ++N + E
Sbjct: 1268 KNLKSLLNN--SKLEQTRLEAE--FSKLKEQYQQLDITSTKLNNQCE 1310
Score = 64.3 bits (155), Expect = 3e-10
Identities = 111/552 (20%), Positives = 218/552 (39%), Gaps = 87/552 (15%)
Query: 133 KRFLEERKEELEEVAHELAETEHENTVLRH-------NIERMKEEKDFTIL--------- 176
K+ LE ++E++ + L E+ + N LR N E +K+ +D +
Sbjct: 965 KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1024
Query: 177 -----QKKHLQQEKECLMSK--LVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT 229
+++ + +E L K L+E E + A + ALK + +L+T+ I
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
Query: 230 LTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLL 289
L RQ L ++ +T + N L+ + S LM Q LL + + ++E ++
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQ--VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1142
Query: 290 LLLQD---------KDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAE 340
+D KD E ELL E Q + ++ + +++S +L+ + R E
Sbjct: 1143 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH--GTLKSAHKNLEVEHRDLEDR 1200
Query: 341 NSRLCMQIKNLERSGNQHKAEV----------EAIMEQLKELKQKGDR------------ 378
++L Q LE K E E + + K+L + DR
Sbjct: 1201 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
Query: 379 -----DKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV 433
D ++LK + K + E +L Q D+ T ++ +
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI-------TSTKLNNQCELLS 1313
Query: 434 KEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLK 493
+ KG+LE E L D++ L+ Q +TL E+ E +D + + + + + E+L+
Sbjct: 1314 QLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1373
Query: 494 ASF---------APMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM-KTRLEADEVAA 543
+P + N L++++L S K+ + KS + TR ++ E
Sbjct: 1374 EKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR--ERQKSLTLTPTRSDSSEGFL 1431
Query: 544 QLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYER 603
QL D ++ + E +S + L++LP + + K D+++ R
Sbjct: 1432 QLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDK-----DKMKACYR 1486
Query: 604 KNIDLTAIISDL 615
+++ + ++ +
Sbjct: 1487 RSMSMNDLVQSM 1498
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/409 (22%), Positives = 168/409 (41%), Gaps = 69/409 (16%)
Query: 261 KEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELS 320
+ED E L++ LKRL + E + ++ L ++ + L AQ+ S
Sbjct: 183 QEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPH--ASSSAQSPCGSPGM 240
Query: 321 KSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKG---- 376
K ES R HL +L +A+ RL +++ K E+E + +LK L+Q+
Sbjct: 241 KRTES-RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 377 ----------DRDKESLKKAIRAQKERAEKSEEYAEQLH--------VQLADKDLYVAEA 418
D +KA+R K +E S Y E+LH V+ +D V
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVS-RYKERLHDIEFYKARVEELKEDNQVLLE 358
Query: 419 LST-----LESWRSRYN----------QVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEK 463
T LE R+R + Q+ + D+E+E + ++ +L+ + TLE
Sbjct: 359 TKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 464 MREDRDSLVERLH--------RQTAEYSAFKLE------NERLKASFAPMEDKLNQAHLE 509
++ D E LH +T+E S + NE + +E +
Sbjct: 419 QKQSMD---ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 510 VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
V++L+ +V + EG S+++K E +R K+ +IL++E+ +E ++ +
Sbjct: 476 VEELRTTVDSVEG----NASKILKMEKEN-------QRLSKKVEILENEIVQEKQSLQNC 524
Query: 570 FQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSR 618
+++ + K E + Q++ E++N L +S LR R
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 107 bits (268), Expect = 3e-23
Identities = 128/582 (21%), Positives = 247/582 (42%), Gaps = 60/582 (10%)
Query: 94 DDSGHCK-----MNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAH 148
D HC + Y +K SL L+ ++K + + K E+ ++L++
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Query: 149 ELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMA 208
+ E T L +E KE T L + + E + KL + E + +
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 209 LKDTIG----KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 264
L +L Q T T++ + +KE L+ +LST ++ + D L+ + +
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 265 ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSME 324
E + + A+L K +L + +++ KE +EL + ++ EK + SM+
Sbjct: 879 EN-QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 325 SMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLK-------ELKQKGD 377
Q L+ E E +L I L++S Q K ++EA+ +LK EL+ K
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 378 RDKESLKKAIRAQKERA-------EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYN 430
+ + + A+KE+ EKS+E +QL ++ +E L+T + +S
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE---SELLATRQDLKS--- 1051
Query: 431 QVVKEKGDLELEIIVLNDR--------VTDLVNQQQTLEEKMREDRDSLVER---LHRQT 479
V+EK L E ++ N + +L + TLE+ + L ER L
Sbjct: 1052 --VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 480 AEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYE----GMIDNYK------- 528
E S + E K+ A +E+ + E+ +L +K+++ I N K
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 529 SQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITE 588
Q ++ + +AD + A +E+ + +ILKD++ KE E +++F + A L +I E
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS-----EIKE 1224
Query: 589 AKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELT 630
++ + + + + + +TA+ +L + ++WQ ++
Sbjct: 1225 KEVGMKKHE-ENEAKLTMQITALNENLGTVKKEWQSSQRRVS 1265
Score = 88.2 bits (217), Expect = 2e-17
Identities = 125/625 (20%), Positives = 256/625 (40%), Gaps = 79/625 (12%)
Query: 72 ITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQM 131
+T S+E +L + TE+ + K + +++K L + +KS+ ++ R+
Sbjct: 130 VTDSSAELQSLEQQLEEAQTENFNIKQMK-DLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 132 AKRFLEERKEELEEVAHEL-------------------------AETEHENTVLRHNIER 166
A++ + EEL + A + +T +N L E
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 167 MKEEKDFTILQKKHLQQEKEC--LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTC 224
K + + LQ ++ E L S+L + + A +++ LK ++ +L T+K T
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL-TQKNQTL 307
Query: 225 TDINTLTRQKEL--LLQKLSTFEETNRTLRDLLREQ--HCKEDSERLMEQQGALLKRLAE 280
T+ N L ++++ L +K + + + ++ L ++ C++ RL + + L R+
Sbjct: 308 TE-NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS-LHRIHV 365
Query: 281 ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE----------------LSKSME 324
SEK L+++ EVE Q ++ E Q + E SK +E
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425
Query: 325 SMR------GHLQAQ-------LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 371
+ R G L+ Q L KE + + L +++ LE + + QL +
Sbjct: 426 TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 485
Query: 372 LKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQ 431
KQ+ +++++L+++ A+ A+ EQ+ Q+ DKD + + L+ + +
Sbjct: 486 TKQQ-HQEQQALQQSTTAKLREAQND---LEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
Query: 432 VVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENER 491
+ KE+ DL + I + T ++NQ Q ++E L E+L Q+ + K E
Sbjct: 542 LEKEREDLYAK-IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH---KQAQEN 597
Query: 492 LKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKE 551
L + L A V L+ SV ++ K +V + ++ L +
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 552 NKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD-------QLQGYERK 604
+ ++ ++ A+ Q + +L ++ L AKL + Q+ L+ Y+ K
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 605 NIDLTAIISDLRSRVRDWQKGSHEL 629
+ L +L +++ + S E+
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEV 742
Score = 82.4 bits (202), Expect = 1e-15
Identities = 103/530 (19%), Positives = 232/530 (43%), Gaps = 50/530 (9%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
LK+E K + +R+ ++ + + E+ ++ +L ETE + L R+KE++ + +
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ---LGEAHGRLKEQRQLSSEK 447
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTE-------KQMTCTDINTL 230
+Q+ L KL E L+ + K K + +Q T +
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
E +L+++ ++ + L LL Q KE+ L +++ L ++ + E A +L
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALL--QKSKENISLLEKEREDLYAKIQAGEGETA-VLN 564
Query: 291 LLQDKD----KEVEELLQEIQCEKAQAKTASE-LSKSMESMRGHLQA---QLRSKEAENS 342
LQ+K+ ++V +L ++++ + K A E L ++ + HL+A ++ S E +
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQL-----KELKQKGDRDK--ESLKKAIRAQKERAE 395
L Q+ + +Q +++A E L + Q+ D ++ + A++ +++
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684
Query: 396 KSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVN 455
K +Q+ +L DK + ++ S L+ ++ +Y + ++ +LE +I L
Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL--------- 735
Query: 456 QQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKA 515
+ +LE ++ ++ ++ L +Q + +L L ++ ++ L++Q+
Sbjct: 736 EADSLE--VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 516 SVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 575
+ +++ K ++ K E + E +E KI +E+N I+ + Q
Sbjct: 794 A-------LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846
Query: 576 DLQQLPDILKITEAKLAECQDQLQG----YERKNIDLTAIISDLRSRVRD 621
+ + L L + KL++ D L+ +E++N A I DL ++
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
Score = 82.4 bits (202), Expect = 1e-15
Identities = 92/459 (20%), Positives = 200/459 (43%), Gaps = 45/459 (9%)
Query: 106 KKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIE 165
K ++ A LK E+ + + A+ L++ ++E +++ + E + + + IE
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 166 RMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCT 225
++ E +LQK L+ + L +L +A + AA +++ L++ K + + +
Sbjct: 977 ALQGELKIAVLQKTELENK---LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 226 DINTLTRQKELLL--QKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADS 283
D R+ ELL Q L + EE ++ L + ++ + Q+ K E DS
Sbjct: 1034 DF--YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS 1091
Query: 284 EKARLLL-----LLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKE 338
K L LQD KE +E+ EK++ E+ E L +L+S +
Sbjct: 1092 AKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
Query: 339 AENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKS- 397
E+ + +K+ ++ Q K E++ + LK ++ R+++ LK ++ ++E +K
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF 1211
Query: 398 EEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQ 457
E +LH ++ +K++ + + + + L ++I LN+ + + +
Sbjct: 1212 IEKEAKLHSEIKEKEVGM--------------KKHEENEAKLTMQITALNENLGTVKKEW 1257
Query: 458 QTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASV 517
Q+ + ++ E L +QT + L+ A +E + E + L
Sbjct: 1258 QSSQRRVSE--------LEKQT----------DDLRGEIAVLEATVQNNQDERRALLERC 1299
Query: 518 KNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILK 556
EG I+ +++V++ + + D A ++ +EN+ L+
Sbjct: 1300 LKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 80.9 bits (198), Expect = 3e-15
Identities = 97/523 (18%), Positives = 221/523 (42%), Gaps = 48/523 (9%)
Query: 121 EVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH 180
++K E + L E + E+ +L E +E +V + NI+ +KD Q +
Sbjct: 292 KLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQS 351
Query: 181 LQQEKECLMSKL-VEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQ 239
E + ++ VE G A K LK+ + +++T+ Q + L +Q+E Q
Sbjct: 352 RLSASETSLHRIHVELSEKGEATQK----LKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
Query: 240 K-LSTFEETNRTLRDLLR-EQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK 297
L E N+ LL E+ E RL EQ+ ++L + + + A L L L ++
Sbjct: 408 HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
Query: 298 EVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQ-------IKN 350
+++E + + Q + + ++++ A+LR + + ++ Q I+N
Sbjct: 468 QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
Query: 351 LERSGNQHKAEVEAIMEQ-----------------LKELKQKGDRDKESLKKAIRAQKER 393
LE + K + + ++ L +L++K +E + + K +
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
Query: 394 AEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRV--- 450
+E ++ E LH Q+ ++ ++ A + S + N++ + + + ++ L+ ++
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
Query: 451 TDLVNQQQTLEEKMRED----RDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQA 506
T+L+ + + R D D+ L + E + + +++ A ++ +Q
Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 507 HLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERC----------DKENKILK 556
+++ K + E + + Q+ K ++ EV A E+ + + ++
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 557 DEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQ 599
E++K++E + S DLQ+ + L+ + KL + +++ Q
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Score = 79.0 bits (193), Expect = 1e-14
Identities = 118/586 (20%), Positives = 234/586 (39%), Gaps = 85/586 (14%)
Query: 76 SSEKLVSV-MRLSDLSTEDDDSGHCKMNRYDKKIDS-------LMNAVGCLKSEVKMQKG 127
SSEKL+ +++DL K++R ++++ L + + K + + Q+
Sbjct: 444 SSEKLMDKEQQVADLQL--------KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 128 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 187
+Q L E + +LE+V ++ + + + L +++ KE L++E+E
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL-------LEKERED 548
Query: 188 LMSKLVEAEMDGAAA----------AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
L +K+ E + A +QV L + + + +++ ++++
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
Query: 238 LQ----KLSTFEETNRTLRDLLREQ---------HCKEDSERLMEQQGALLKRLAEADSE 284
L+ ++ + E + L L E K +E L+ + A + A+ +
Sbjct: 609 LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNH 668
Query: 285 KARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRL 344
LQDK +E+ ++ ++ A+ + E +ES + + S E + L
Sbjct: 669 LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 345 CMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQL 404
QIK LE + KA E ++ L++ +Q L+ ++ E +E
Sbjct: 729 EGQIKKLEADSLEVKASKEQALQDLQQQRQL----NTDLELRATELSKQLEMEKEIVSST 784
Query: 405 HVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM 464
+ L K LES + + + +EK L+ + +TL ++
Sbjct: 785 RLDLQKKS-------EALESIKQKLTKQEEEKQILKQDF--------------ETLSQET 823
Query: 465 REDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMI 524
+ + L R+ E K+E E L + ++DKL++ LK S +E
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS---DSLKNSKSEFEKEN 880
Query: 525 DNYKSQVM---KTRLE-ADEVAAQLERCDKENKILKDEMNKEIEAARR---QFQSQLADL 577
K+ ++ KT E ++ Q+E KE K LK + KE EA+ + + S L
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 578 QQLPDILKITEAKLAECQDQL----QGYERKNIDLTAIISDLRSRV 619
Q + LK E + + Q + Q E+K + A+ +L+ V
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986
Score = 58.9 bits (141), Expect = 1e-08
Identities = 103/472 (21%), Positives = 192/472 (40%), Gaps = 54/472 (11%)
Query: 194 EAEMDGAAAAKQVMALK-DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLR 252
+A D + +ALK D + L+ E Q + E L ++L ++
Sbjct: 65 DAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG------ 118
Query: 253 DLLREQHCKED---SERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 309
L++Q K D ++ E Q +L ++L EA +E + + +++ +L EI
Sbjct: 119 --LQQQEAKPDGLVTDSSAELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADI 175
Query: 310 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 369
K++ L ++ E L +L + L ++ L+R G + A ++ + Q+
Sbjct: 176 KSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL--LQRPGIEDVAVLKKELVQV 233
Query: 370 KELKQ----KGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 425
+ L + +R+ E LK + + + SE QL +LA VA + L+
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL 293
Query: 426 RSRYNQVVKEKGDLELEIIVLNDRVTDLV-----------NQQQTLEEK-----MREDRD 469
+S N++ ++ L ++ T L N Q TL +K + R
Sbjct: 294 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRL 353
Query: 470 SLVER-LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYE------- 521
S E LHR E S ++LK + +E K E +QL+ + E
Sbjct: 354 SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ 413
Query: 522 GMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDE--MNKEIEAARRQFQSQLADLQQ 579
I+ S++++T + E +L KE + L E M+KE + A Q + L +
Sbjct: 414 SEINQLHSKLLETERQLGEAHGRL----KEQRQLSSEKLMDKEQQVADLQLK-----LSR 464
Query: 580 LPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTR 631
L + LK E Q QL ++++ + A+ +++R+ Q ++ R
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 104 bits (259), Expect = 3e-22
Identities = 139/588 (23%), Positives = 228/588 (38%), Gaps = 110/588 (18%)
Query: 86 LSDLSTEDDDSGHCKMN--RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEEL 143
L DL+ + D N + KK D L+ E+ ++ R+ EER
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAE-------------EKSISARYAEER---- 1471
Query: 144 EEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA 203
+ E E E + L +E E K+ Q K L+ + E LMS
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS------------ 1519
Query: 204 KQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKED 263
KD +GK +++ L + K L Q++ EE L +L E ED
Sbjct: 1520 ------KDDVGK----------NVHELEKSKRALEQQV---EEMRTQLEELEDELQATED 1560
Query: 264 SERLMEQQGALLKRLAEAD--------SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKT 315
++ +E +K E D EK RLL+ K+V EL E++ E+ Q
Sbjct: 1561 AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI------KQVRELEAELEDERKQRAL 1614
Query: 316 ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQK 375
A K ME L+AQ+ + + Q++ L+ ++ E+E E+ +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674
Query: 376 GDRDKESLK----KAIRAQKERA--EKSEEYAEQLHVQLADKDLYVAEALSTL----ESW 425
++ LK + ++ Q+E A E++ +AEQ +LAD+ A S L
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRL 1734
Query: 426 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDR------DSLVERLHRQT 479
+R Q+ +E + + + +LNDR Q TL ++ +R D+ ++L RQ
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQN 1794
Query: 480 AEYSA------------FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNY 527
E A FK L+A +E++L Q E V+ E +
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI 1854
Query: 528 KSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKIT 587
QV R AD+ Q+E+ + K LK ++ + E A R
Sbjct: 1855 FMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR------------------A 1896
Query: 588 EAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRAGAR 635
A + Q +L N L+ +S L++R+R S +R+G R
Sbjct: 1897 NASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRR 1944
Score = 88.6 bits (218), Expect = 2e-17
Identities = 117/602 (19%), Positives = 259/602 (43%), Gaps = 57/602 (9%)
Query: 60 RVKTKNPPHCLEITPPSSE---KLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVG 116
RV TK P L++T E K ++++ + T+ + ++ ++K L+
Sbjct: 836 RVFTKVKP-LLQVTRQEEELQAKDEELLKVKEKQTKVEG----ELEEMERKHQQLLEEKN 890
Query: 117 CLKSEVKMQK---GERQMAKRFLEERKEELEEVAHEL----AETEHENTVLRH------- 162
L +++ + E + + L +K+ELEE+ H+L E E N +L++
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 163 NIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQM 222
+I+ ++E+ D ++ LQ EK +K+ + E ++++ L+D K EK++
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKME-------EEILLLEDQNSKFIKEKKL 1003
Query: 223 ------TCTDINTLTRQKELLLQKLSTFEET------NRTLRDLLREQHCKEDSERLMEQ 270
C+ +K L K+ +E R ++ Q ++ +L +
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
L ++AE ++ L L L K++E++ L E A ++ + +++ L
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 331 QAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAI 387
Q S++A ++ Q ++L K E+E ++ +EL+ K +++ LKKA+
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 388 RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN 447
+ + E + Q H ++ ++E L + +++ + K K LE + L
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEE---LSEQLEQAKRFKA---NLEKNKQGLETDNKELA 1237
Query: 448 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLE----NERLKASFAPMEDKL 503
V ++ Q + E R+ D+ V+ LH + +E ++E +L+ + L
Sbjct: 1238 CEV-KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 504 NQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEI 563
+A + + + E + + + + + + +++++ + ++E L+++ +E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE- 1355
Query: 564 EAARRQFQSQLADLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDW 622
E AR+ + Q+ LQ QL D K + L + + ++ D A+ L + +
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 623 QK 624
K
Sbjct: 1416 DK 1417
Score = 78.6 bits (192), Expect = 2e-14
Identities = 111/511 (21%), Positives = 218/511 (42%), Gaps = 56/511 (10%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKE----ELEEVAHELAETEH 155
+ R +K++ + M + K +V E + +KR LE++ E +LEE+ EL TE
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED 1560
Query: 156 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGK 215
L N++ MK + + + + +EK+ L+ K V ++ +
Sbjct: 1561 AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV----------------RELEAE 1604
Query: 216 LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALL 275
L+ E++ + + ++ E+ L+ L E RD + +Q +L Q
Sbjct: 1605 LEDERKQRALAVAS-KKKMEIDLKDLEAQIEAANKARDEVIKQ-----LRKLQAQMKDYQ 1658
Query: 276 KRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLR 335
+ L EA + + + ++ +K+++ L EI + + ++ + E R L ++
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT 1718
Query: 336 SKEAENSRLCMQIKNLERSGNQHKAEVE---AIMEQLKELKQKGDRDKESLKKAIRAQKE 392
+ + S L + + LE Q + E+E + ME L + +K ++L + A++
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERS 1778
Query: 393 RAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTD 452
A+KS+ +QL Q +K+L L LE VK K + I L ++
Sbjct: 1779 AAQKSDNARQQLERQ--NKEL--KAKLQELEG-------AVKSK--FKATISALEAKIGQ 1825
Query: 453 LVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQ 512
L +Q E K R + LV R ++ E ++E+ER A ++++ +A+ ++Q
Sbjct: 1826 L-EEQLEQEAKERAAANKLVRRTEKKLKEI-FMQVEDERRHAD--QYKEQMEKANARMKQ 1881
Query: 513 LKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK-------EIEA 565
LK ++ E + K + E D+ E +E LK+ + + +
Sbjct: 1882 LKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRS 1941
Query: 566 ARRQFQSQLADLQQLPDILKITEAKLAECQD 596
RRQ + A L+ D TE+K ++ +
Sbjct: 1942 GRRQLHLEGASLELSDD---DTESKTSDVNE 1969
Score = 76.6 bits (187), Expect = 6e-14
Identities = 122/550 (22%), Positives = 234/550 (42%), Gaps = 79/550 (14%)
Query: 89 LSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAH 148
L+ DD++ H N K + L + L+ + + +K R A++ + EELE +
Sbjct: 1096 LARGDDETLH--KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKT 1153
Query: 149 ELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA----AK 204
EL +T +T R K E++ L KK L++E + +++ + A A ++
Sbjct: 1154 ELEDTL--DTTAAQQELRTKREQEVAEL-KKALEEETKNHEAQIQDMRQRHATALEELSE 1210
Query: 205 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 264
Q+ K L+ KQ TD L + ++L Q + E + L ++E H K
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK--- 1267
Query: 265 ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSME 324
+ + L LAE S+ LQ++ V LL+E EK K A + + S+E
Sbjct: 1268 ---VSEGDRLRVELAEKASK-------LQNELDNVSTLLEE--AEKKGIKFAKDAA-SLE 1314
Query: 325 SMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLK 384
S Q L+ + + L +I+ LE N L+E +++ + +++L+
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS-----------LQEQQEEEEEARKNLE 1363
Query: 385 KAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLEL--- 441
K + A L QLAD V + L T+ES +++K+ L
Sbjct: 1364 KQVLA--------------LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 442 EIIVLNDRVTDLVNQQQTLEEKMREDRD---SLVERLHRQTAEYSAFKLENERLKASFAP 498
E + D++ N+ Q + + D D + L ++ ++ E + + A +A
Sbjct: 1410 EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE 1469
Query: 499 MEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKI-LKD 557
D+ A E ++ + + ++ + ++ + E + QL R D E+ + KD
Sbjct: 1470 ERDR---AEAEAREKETKALSLARALE----EALEAKEEFERQNKQL-RADMEDLMSSKD 1521
Query: 558 EMNK---EIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISD 614
++ K E+E ++R + Q+ +++ +L E +D+LQ E + L +
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMR----------TQLEELEDELQATEDAKLRLEVNMQA 1571
Query: 615 LRSRV-RDWQ 623
++++ RD Q
Sbjct: 1572 MKAQFERDLQ 1581
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/233 (21%), Positives = 107/233 (45%), Gaps = 45/233 (19%)
Query: 431 QVVKEKGDLEL---EIIVLNDRVTDLVNQQQTLEEK---MREDRDSLVERLHRQTAEYSA 484
QV +++ +L+ E++ + ++ T + + + +E K + E+++ L E+L +T ++
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 485 FKLENERLKASFAPMEDKLNQAHLEVQQ--------------LKASVKNYEGMIDNYKSQ 530
+ RL A +E+ L+ V++ ++A +++ E +D +
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 531 VMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAK 590
K +LE A++++ ++E +L+D+ +K I+ K+ E +
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK------------------KLMEDR 1007
Query: 591 LAECQDQLQGYERKNIDLTAI-------ISDLRSRVRDWQKGSHELTRAGARI 636
+AEC QL E K +L I ISDL R++ +K EL +A ++
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 100 bits (249), Expect = 4e-21
Identities = 143/648 (22%), Positives = 281/648 (43%), Gaps = 77/648 (11%)
Query: 45 KRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSV-MRLSDLSTEDDDSGHCKMNR 103
KR ++GD + S + T+N L +EKL +S+L + +D + +
Sbjct: 1056 KRKLEGDLKLAQEST-MDTENDKQQL------NEKLKKKEFEMSNLQGKIEDEQALAI-Q 1107
Query: 104 YDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTV-LRH 162
KKI L + L+ E++ ++ R A++ + ELEE++ L E + +
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167
Query: 163 NIERMKE-EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQ 221
N +R E +K L++ LQ E + A+ A +Q+ +L+ KL+ EK
Sbjct: 1168 NKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD-SVAELGEQIDSLQRVKQKLEKEKS 1226
Query: 222 MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE------------RLME 269
+IN L E + + + FE+ RTL D L E KE+ + RL
Sbjct: 1227 ELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHT 1286
Query: 270 QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGH 329
+ G ++L E D+ ++L Q +++EEL ++++ + K S L+ +++S R
Sbjct: 1287 ESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE---EETKAKSTLAHALQSARHD 1343
Query: 330 ---LQAQLRSKEAENSRL--CMQIKNLERSGNQHKAEVEAIM--EQLKELKQKGDRDKES 382
L+ Q ++ + L M N E + + K E +AI E+L+E K+K + +
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1403
Query: 383 LKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS--------------TLESWRSR 428
++ + A + E+ ++L ++ D + V + + L W+ +
Sbjct: 1404 AEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQK 1463
Query: 429 YNQV-------VKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAE 481
Y + KE L E+ + + + ++ +TL+ + + + + + L Q AE
Sbjct: 1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD-LTEQIAE 1522
Query: 482 YSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEV 541
E E++K Q E +L+ S++ E +++ + ++++ +LE ++V
Sbjct: 1523 GGKHIHELEKVK----------KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQV 1572
Query: 542 AAQLERCDKENKILKDEMNKEIEAARRQFQSQL-ADLQQLPDILKI---TEAKLAECQDQ 597
++++R E D++ + QS L A+++ D L+I E L E + Q
Sbjct: 1573 KSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ 1632
Query: 598 LQGYER------KNIDLT-AIISDLRSRVRDWQKGSHELTRAGARIPR 638
L R +N+ T I+ D + + D +G +L A + R
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVER 1680
Score = 85.5 bits (210), Expect = 1e-16
Identities = 120/558 (21%), Positives = 231/558 (41%), Gaps = 73/558 (13%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
+K +K + E++MA KEE E+ ELA+TE + L EEK T++Q
Sbjct: 840 IKPLLKSAETEKEMANM-----KEEFEKTKEELAKTEAKRKEL--------EEKMVTLMQ 886
Query: 178 KKH-LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT-LTRQKE 235
+K+ LQ + + L +AE K + L+ I K TE+ +IN LT +K
Sbjct: 887 EKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKI-KEVTERAEDEEEINAELTAKKR 945
Query: 236 LLLQKLS----TFEETNRTLRDLLREQHCKEDS-ERLMEQQGALLKRLAEADSEKARL-- 288
L + S ++ TL + +E+H E+ + L E+ L + +A+ EK L
Sbjct: 946 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005
Query: 289 --------LLLLQDK-----------DKEVEELLQEIQCEK--------------AQAKT 315
L + +DK +++V++L ++ EK K
Sbjct: 1006 AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKL 1065
Query: 316 ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQK 375
A E + E+ + L +L+ KE E S L +I++ + Q + +++ + +++EL+++
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125
Query: 376 GDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE 435
+ ++ S KA + + + + + EE +E+L + + +E + R + K
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERL-------EEAGGATSAQIEMNKKREAEFQKM 1178
Query: 436 KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLE------- 488
+ DLE + L + ++ E DSL + E S K+E
Sbjct: 1179 RRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASN 1238
Query: 489 NERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERC 548
E + + A E ++ ++K + + +I+ +Q + E+ E + QL+
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298
Query: 549 DKENKIL---KDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 605
D L K ++IE +RQ + + L L+ ++Q + +
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAK 1358
Query: 606 IDLTAIISDLRSRVRDWQ 623
+L +S S V W+
Sbjct: 1359 AELQRGMSKANSEVAQWR 1376
Score = 73.9 bits (180), Expect = 4e-13
Identities = 101/561 (18%), Positives = 239/561 (42%), Gaps = 81/561 (14%)
Query: 123 KMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFT-----ILQ 177
++++ ++++A+R L++ +E +E V + A E L++ +E + + + + L
Sbjct: 1389 ELEEAKKKLAQR-LQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALD 1447
Query: 178 KKHLQQEKECL--MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKE 235
KK +K K E + + A+ K+ +L + K+K + + + TL R+ +
Sbjct: 1448 KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENK 1507
Query: 236 LLLQKLSTF-----------EETNRTLRDLLRE----QHCKEDSERLME-QQGALLKRLA 279
L Q++S E + + L E Q E++E +E ++G +L+
Sbjct: 1508 NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQL 1567
Query: 280 EADSEKARLLLLLQDKDKEVEELLQE-----------IQCEKAQAKTASELSKSMESMRG 328
E + K+ + + +KD+E+++L + + E A + K ME
Sbjct: 1568 ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN 1627
Query: 329 HLQAQLRSKEAENSRLCMQIKNLE---RSGNQHKAEVEAIMEQLKELKQKGDRDKESLK- 384
++ QL + + ++N + + H + + LKE +R ++
Sbjct: 1628 EMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQA 1687
Query: 385 --KAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELE 442
+ +RA ER E+ + AEQ + +A ++ ++ ++ K LE +
Sbjct: 1688 EVEELRASLERTERGRKMAEQ----------ELLDASERVQLLHTQNTSLINTKKKLETD 1737
Query: 443 IIVLNDRVTDLVNQQQTLEEKMRE---DRDSLVERLHRQTAEYSAFKLENERLKASFAPM 499
I + + D+V + + EEK ++ D + E L ++ + + + ++ + +
Sbjct: 1738 ISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1797
Query: 500 EDKLNQAH--------LEVQQLKASVKNYEGMIDNYKSQ-------VMKTRLEADEVAAQ 544
+ +L++A ++Q+L+A V+ E +++ + + K E+ Q
Sbjct: 1798 QLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQ 1857
Query: 545 LERCDKENKI----LKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 600
E D++N + L D++ +++A +RQ ++ + + AK + Q +L+
Sbjct: 1858 TEE-DRKNILRLQDLVDKLQTKVKAYKRQ-------AEEAEEQSNVNLAKFRKLQHELEE 1909
Query: 601 YERKNIDLTAIISDLRSRVRD 621
+ + + ++ LR + R+
Sbjct: 1910 AKERADIAESQVNKLRVKSRE 1930
Score = 37.4 bits (85), Expect = 0.043
Identities = 51/249 (20%), Positives = 109/249 (43%), Gaps = 17/249 (6%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
+++EV+ + + +R + ++EL + + + +NT L + ++++ + +
Sbjct: 1685 MQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKL---KTEKQMTCTDINTLTRQK 234
+ + QE K +A D A A+++ +DT L K + T D+ +
Sbjct: 1745 MEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1804
Query: 235 ELLLQK-----LSTFEETNRTLR-DLLREQHCKEDSERLMEQQGALLKRLAEADSEKARL 288
E L K + E R L ++ EQ ++ + + + +K L E +
Sbjct: 1805 EQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKN 1864
Query: 289 LLLLQDKDKEVEELLQEIQCEKAQAKTASE-----LSKSMESMRGHLQAQLRSKEAENSR 343
+L LQD V++L +++ K QA+ A E L+K + +A+ R+ AE+
Sbjct: 1865 ILRLQDL---VDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQV 1921
Query: 344 LCMQIKNLE 352
+++K+ E
Sbjct: 1922 NKLRVKSRE 1930
Score = 31.2 bits (69), Expect = 3.1
Identities = 31/136 (22%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 507 HLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAA 566
+ +++ L S + + M N K + KT+ E + A+ + +++ L E N +++
Sbjct: 837 YFKIKPLLKSAETEKEMA-NMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN-DLQLQ 894
Query: 567 RRQFQSQLADLQQLPDILKIT----EAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDW 622
+ LAD ++ D L T EAK+ E ++ + E N +LTA L +
Sbjct: 895 VQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 623 QKGSHELTRAGARIPR 638
+K +L A++ +
Sbjct: 955 KKDIDDLELTLAKVEK 970
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 99.8 bits (247), Expect = 7e-21
Identities = 115/540 (21%), Positives = 240/540 (44%), Gaps = 37/540 (6%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHEL-AETEHENTVLRH----------NIER 166
L++E ++ ++ R L +K+ELEE+ H+L A E E +H NI+
Sbjct: 889 LQAETELCAEAEELRAR-LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE 947
Query: 167 MKEEKDFTILQKKHLQQEK---ECLMSKLVEAEM----DGAAAAKQVMALKDTIGKLKTE 219
++E+ + ++ LQ EK E + KL E ++ AK+ L+D I + T
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 220 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLA 279
+L + K ++ EE R R+ + Q ++ +L L ++A
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEE--RLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 280 EADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEA 339
E ++ A L + L K++E++ L ++ E AQ A + + +ES LQ L S+ A
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 340 ENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEK 396
++ Q ++L K E+E ++ +EL+ K +++ LKK + + + E
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 397 SEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVK-EKGDLELEIIVLNDRVTDLVN 455
+ Q H Q ++ E +++ + Q ++ E+G+L E+ VL D +
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245
Query: 456 QQQTLEEKMRE--DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQL 513
+++ +E +++E + + ER+ + A+ + +L+ + L+Q+ + +L
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELAD------KVTKLQVELDNVTGLLSQSDSKSSKL 1299
Query: 514 KASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ 573
E + + + + + + ++ +L++ + E ++++ +E E A+ + Q
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE-EEAKHNLEKQ 1358
Query: 574 LADLQ-QLPDILKITEAKLAECQDQLQGYERK-NIDLTAIISDLRSRVRDWQKGSHELTR 631
+A L Q+ D+ K E + C + + +RK DL + +V + K TR
Sbjct: 1359 IATLHAQVADMKKKMEDSVG-CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Score = 96.3 bits (238), Expect = 8e-20
Identities = 115/543 (21%), Positives = 226/543 (41%), Gaps = 65/543 (11%)
Query: 136 LEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEA 195
+ ++EE+ EL + + + + M+ + + +K LQ++ + EA
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 196 EMDGAAAAKQVMALKDTIGKLKT---EKQMTCTDINTLTRQKELLLQKL-STFEETNRTL 251
E A + L++ L+ E++ C + ++ + +Q+L EE
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR 959
Query: 252 RDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKA 311
+ L E+ E + +E++ +L+ + + + A+ LL+D+ E L E E+
Sbjct: 960 QKLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLTE---EEE 1013
Query: 312 QAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 371
++K+ ++L E+M L+ +LR +E + L + LE ++ + Q+ E
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 372 LKQKGDRDKESLKKAI-RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYN 430
LK + + +E L+ A+ R ++E A+K+ ++ + + ++E LES R+ N
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALK-----KIRELESQISELQEDLESERASRN 1128
Query: 431 QVVKEKGDLELEIIVLNDRVTDLVNQ------------------QQTLEE---------- 462
+ K+K DL E+ L + D ++ ++TLEE
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 463 KMREDRDSLVERLHRQTAEYSAFK---------LENER---------LKASFAPMEDKLN 504
+MR+ VE L Q + K LENER L E K
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 505 QAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD-KENKILKD--EMNK 561
+ ++Q+L+ E + +V K ++E D V L + D K +K+ KD +
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 562 EIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRD 621
+++ + Q + L LK E + ++QL+ E +L I+ L ++V D
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 622 WQK 624
+K
Sbjct: 1369 MKK 1371
Score = 96.3 bits (238), Expect = 8e-20
Identities = 123/569 (21%), Positives = 246/569 (43%), Gaps = 53/569 (9%)
Query: 106 KKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIE 165
KKI L + + L+ +++ ++ R A++ + EELE + EL +T ++T + +
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT-LDSTAAQQEL- 1161
Query: 166 RMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTEKQ 221
R K E++ IL KK L++E + +++ E + A A+Q+ K L+ KQ
Sbjct: 1162 RSKREQEVNIL-KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 222 MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSERLMEQQGALLKR--- 277
+ L + ++LLQ E + + L+E K + ER+ + + +
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 278 --------LAEADSEKARL---LLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESM 326
L+++DS+ ++L L+ + ++ +ELLQE E Q + S K +E
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE---ENRQKLSLSTKLKQVEDE 1337
Query: 327 RGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVE---AIMEQLKELKQKGDRDKESL 383
+ + QL +E L QI L K ++E +E +E+K+K +D E L
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397
Query: 384 KKAIRAQKERAEKSEEYAEQLHVQLAD--KDL-YVAEALSTLESWRSRYNQVVKEKGDLE 440
+ + +K E+ +L +L D DL + ++ LE + +++Q++ E+ +
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 441 LEIIVLNDRVTDLVNQQQT--------LEEKMREDRDSLVERLHRQ-TAEYSAFKLENER 491
+ DR +++T LEE M + + +ERL++Q E +
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE--LERLNKQFRTEMEDLMSSKDD 1515
Query: 492 LKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERC--- 548
+ S +E +V+++K ++ E + + ++ + + AQ ER
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575
Query: 549 ------DKENKILKD--EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 600
+K+ ++++ EM E+E R+Q +A ++L LK EA +
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 601 YERKNIDLTAIISDLRSRVRDWQKGSHEL 629
++ L A + D + D + E+
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEI 1664
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/479 (20%), Positives = 202/479 (42%), Gaps = 66/479 (13%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 155
++ R +K+ + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 156 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDG---------AAAA 203
L N++ MK + + + + +EK+ + + V EAE++ AA
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 204 KQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKED 263
K M LKD + + + I L + + + + ++T + ++L + KE+
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ--AKEN 1671
Query: 264 SERLMEQQGALLKRLAE-ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
++L + +++ E A +E+A+ + +E +EL EI + A E
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAK-----RQAQQERDELADEIANSSGKGALALE---- 1722
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
E RL +I LE + + E I ++LK K + +
Sbjct: 1723 -----------------EKRRLEARIAQLEEELEEEQGNTELINDRLK----KANLQIDQ 1761
Query: 383 LKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELE 442
+ + ++ A+K+E +QL Q + + + E T+ +S+Y + LE +
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV---KSKYKASITA---LEAK 1815
Query: 443 IIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDK 502
I L +++ + ++Q +++R L + L ++++ER A +D+
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVL---------LQVDDERRNAE--QYKDQ 1864
Query: 503 LNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK 561
++A ++QLK ++ E + K + E ++ + ++E LK+++ +
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 71.6 bits (174), Expect = 2e-12
Identities = 115/535 (21%), Positives = 225/535 (42%), Gaps = 55/535 (10%)
Query: 86 LSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKM---QKGERQMAKRFLEERKEE 142
+ +L+ + + + K N +K +L N G L +EVK+ KG+ + ++ +E +
Sbjct: 1198 VEELAEQLEQTKRVKAN-LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE---AQ 1253
Query: 143 LEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA 202
L+E+ + E E T L + +++ E D L + + SKL + D +A
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELD----NVTGLLSQSDSKSSKLTK---DFSAL 1306
Query: 203 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK- 261
Q+ ++ + + +K T + + +K ++L EE L + H +
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366
Query: 262 EDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSK 321
D ++ ME L+ E + + L L + +E ++ EK + + EL
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL--EKTKTRLQQELDD 1424
Query: 322 SMESMRGHLQA--QLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRD 379
+ + Q+ L K+ + +L + K + + + EA + +E + K
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA---EAREKETKALSL 1481
Query: 380 KESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEK--- 436
+L++A+ + E ++++ ++ ++ KD V +++ LE + Q V+E
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKD-DVGKSVHELEKSKRALEQQVEEMKTQ 1540
Query: 437 -GDLELEIIVLNDRVTDLVNQQQTLEEKMRED---RDSLVE----RLHRQTAEYSAFKLE 488
+LE E+ D L Q ++ + D RD E +L RQ E A +LE
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA-ELE 1599
Query: 489 NERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERC 548
+ER + S A K +L+ +K+ E ID+ DE QL +
Sbjct: 1600 DERKQRSMAVAARK---------KLEMDLKDLEAHIDS-------ANKNRDEAIKQLRKL 1643
Query: 549 DKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYER 603
+ +KD M +E++ R + LA ++ LK EA++ + Q++L ER
Sbjct: 1644 QAQ---MKDCM-RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAER 1694
Score = 68.9 bits (167), Expect = 1e-11
Identities = 112/504 (22%), Positives = 213/504 (42%), Gaps = 101/504 (20%)
Query: 215 KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL 274
K+K Q++ + + +++EL+ + NR + + +L EQ A
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 275 LKRLAEADSEKARLLLLLQDKD----------KEVEELLQEIQCEKAQ-AKTASELSKSM 323
+ AEA+ +ARL Q+ + +E EE Q +Q EK + + EL + +
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 324 ---ESMRGHLQAQLRSKEA--------------ENSRLCMQIKNLE-------------- 352
ES R LQ + + EA +N +L + K LE
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 353 ---RSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR-AQKERAEKSEEYAE------ 402
+S + K + EA++ L+E ++ ++ ++ L+K R + + + S++ AE
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 403 QLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE 462
+L +QLA K+ + AL+ +E ++ N +K+ +LE +I L + DL +++ + +
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQE---DLESERASRNK 1129
Query: 463 KMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEG 522
++ RD E A K E E S A ++ ++ EV LK K E
Sbjct: 1130 AEKQKRD--------LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK---KTLEE 1178
Query: 523 MIDNYKSQVMKTRLE----ADEVAAQLER-------CDKENKILKDEMNK---------- 561
+++Q+ + R + +E+A QLE+ +K + L++E +
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238
Query: 562 ---EIEAARRQFQSQLADLQ-----------QLPDILKITEAKLAECQDQLQGYERKNID 607
+ E R++ ++QL +LQ +L D + + +L L + K+
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK 1298
Query: 608 LTAIISDLRSRVRDWQKGSHELTR 631
LT S L S+++D Q+ E R
Sbjct: 1299 LTKDFSALESQLQDTQELLQEENR 1322
Score = 29.6 bits (65), Expect = 8.9
Identities = 19/94 (20%), Positives = 38/94 (40%)
Query: 79 KLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEE 138
K+ + D T++ + ++ R +KK+ ++ V + + K + A L++
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 139 RKEELEEVAHELAETEHENTVLRHNIERMKEEKD 172
K +LEE E L+ +E E D
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRELEDATETAD 1908
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 98.6 bits (244), Expect = 2e-20
Identities = 109/533 (20%), Positives = 240/533 (45%), Gaps = 67/533 (12%)
Query: 118 LKSEVKMQKGERQMAKRFLEERK--------EELEEVAHELAETEHENTVLRHNIERMKE 169
++SE+ ++ E + R LEE + ++L+E + + + T L N+++ +
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 170 EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT 229
EKD T+ + L ++ + L + + + A+ + T L KQ T
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQ---ASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
Query: 230 LTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLL 289
L Q LL E+ + D + ++ ++ E + K++ ++ E+
Sbjct: 277 LEEQDHLL-------EDYQKKKEDFTMQISFLQEKIKVYEMEQD--KKVENSNKEE---- 323
Query: 290 LLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK 349
+Q+K+ +EEL +I E+ + + + + + G LQ Q+ K E + +++
Sbjct: 324 --IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
Query: 350 NLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKE---------RAEKSEEY 400
N ++ Q E++ +M ++EL+++ +D + ++ ++ RAE E Y
Sbjct: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
Query: 401 AEQLHVQLADKDLYVAEALSTLESWRSR-----------YNQVVKEKGDLELEIIVLND- 448
+Q+ VQ+ K + + ++ +E ++R Y+ + + ++L + +N+
Sbjct: 442 GQQI-VQM--KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINEL 498
Query: 449 --RVTDLVNQQQTLEEKM---REDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL 503
++ D +Q++ L+E++ E++ +L +L E S + + +R + + A E KL
Sbjct: 499 NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
Query: 504 NQAHLE---VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN 560
N+AH V+ LKA + + ++ K +K E +LE +KE + D M
Sbjct: 559 NEAHKSLSTVEDLKAEIVSAS---ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA 615
Query: 561 KEIEAARRQFQSQL-----ADLQQLPDILKIT-EAKLAECQDQLQGYERKNID 607
+ EA + ++QL +L +L + L+I + + +D L + ++ ID
Sbjct: 616 ESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
Score = 79.0 bits (193), Expect = 1e-14
Identities = 98/553 (17%), Positives = 238/553 (43%), Gaps = 79/553 (14%)
Query: 129 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 188
++ +R ++ER EE+E++ + E E V +++++ K F ++ K E
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-----PELS 2186
Query: 189 MSKLVEAEMDGA-AAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 247
+ ++AE D K++ L++ + + + E + ++ L Q E +QK +E+
Sbjct: 2187 LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE--IQK----KES 2240
Query: 248 NRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL-----LLQDKDKEVEEL 302
L++L +E +D ME+ G +K ++ +L ++Q+K+ E+++L
Sbjct: 2241 TTRLQELEQENKLFKDD---MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
Query: 303 LQEIQCEKAQAK--TASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 360
+++ + Q K T +++ + + L+ Q+ ++ C++ +N E Q
Sbjct: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE--CVK-RNREEEIEQLNE 2354
Query: 361 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK--SEEYAEQLHVQLADKDLYVAEA 418
+E + ++L + QK + SL + + K + + +E+ A + V+ A++++ +
Sbjct: 2355 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMK- 2413
Query: 419 LSTLESWRSRYNQVVKE------------------------------KGDLELEIIVLND 448
+ L+ + NQ+ +E K ELE+++ D
Sbjct: 2414 -NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
Query: 449 RVTDLVNQQ--QTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQA 506
+ L NQ ++ EE + +L RL + + SA LE L + ++D Q
Sbjct: 2473 ALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE---LTQCYKQIKDMQEQG 2529
Query: 507 HLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKE--------------- 551
E + L+ + N + +++ + + ++++ + V + C
Sbjct: 2530 QFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL 2589
Query: 552 NKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAI 611
N++ +DE+ +I A + + + ++ L + + ++ + + E+K ++L +
Sbjct: 2590 NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKL 2649
Query: 612 ISDLRSRVRDWQK 624
+ + R+ +K
Sbjct: 2650 LEGNEKKQREKEK 2662
Score = 77.0 bits (188), Expect = 5e-14
Identities = 117/545 (21%), Positives = 234/545 (42%), Gaps = 88/545 (16%)
Query: 128 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK--------- 178
E+ + +R ++E+ + ++ + EL + L ++++EE++ QK
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989
Query: 179 --KHLQQEKECLMSKLVEAEMDGAAA----AKQVMALKDTIG-------KLKTEKQMTCT 225
+ L QE E LM + +E + KQV AL+ + +L+ EK
Sbjct: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM 2049
Query: 226 DINTLTRQKELLLQKLSTF-------------------EETNRTLRDLLREQHCKEDSER 266
D+ + E L+K+ F ++ + L+ + R Q E R
Sbjct: 2050 DLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTR 2109
Query: 267 LMEQQGALLKRLAEADSE----KARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+EQ LK + SE K +L +Q++++E+E+L ++ E QA S +
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR-ELEQALLVSADTFQ 2168
Query: 323 MESMRGH-----------LQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 371
R H L+ QL+++ R +I NLE Q + E+E E++++
Sbjct: 2169 KVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2228
Query: 372 LKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES--WRSRY 429
L + + K+ ++ ++ + ++ E+L + + + D A+ST + ++
Sbjct: 2229 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-----AMSTQDQHVLFGKF 2283
Query: 430 NQVVKEKGDLELEIIVLNDRVTDLVNQQQ-TLEEKMREDRDSLVERLHRQTAEYSAFKLE 488
Q+++EK E+EI LN++VT L Q + T + K+ E+++ L+ L Q +
Sbjct: 2284 AQIIQEK---EVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQ---IECLMSD 2337
Query: 489 NERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERC 548
E +K + ++LN+ ++QQ A++ M + S+ EAD + QL
Sbjct: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE------EADSLKHQL--- 2388
Query: 549 DKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDL 608
D + E A +Q ++ ++ + ++LK T K+ + +L +R+ +
Sbjct: 2389 --------DVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV 2440
Query: 609 TAIIS 613
I S
Sbjct: 2441 EKIQS 2445
Score = 73.9 bits (180), Expect = 4e-13
Identities = 122/593 (20%), Positives = 238/593 (40%), Gaps = 121/593 (20%)
Query: 71 EITPPSSEKLVSVMRLSDLSTEDDDSGHCKM----NRYDKKIDSLMNAVGCLKSEVKMQK 126
++T +E ++R TE D M +R ++ L+ A+ S+++ K
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAK 1872
Query: 127 -GERQMAKRFLEERKEELEEVA--HELAETEHENTVLRHN--IERMKEE------KDFTI 175
+ ++ + +++E E + EL E HE + R +E K E D
Sbjct: 1873 VTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKT 1932
Query: 176 LQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKE 235
L ++ +Q EK ++ +L + +++ + + +L+ E+Q + L+RQKE
Sbjct: 1933 LFERQIQ-EKTDIIDRLEQ----------ELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 236 LLLQKLSTFE-----ETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
+ + E ET + +++ L Q E +++Q L+ + + + +R +
Sbjct: 1982 AMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALE--IDVEEQVSRFIE 2039
Query: 291 LLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKN 350
L Q+K+ E+ +L Q+ Q L K +E MR L Q +E E +I+
Sbjct: 2040 LEQEKNTELMDLRQQNQA----------LEKQLEKMRKFLDEQAIDREHERDVFQQEIQK 2089
Query: 351 LERS----------GNQHKAEVEAIMEQLKELKQKGDR---DKESLKKAIRAQKERAEKS 397
LE+ EVE + LKE K KE L++ I+ + E EK
Sbjct: 2090 LEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKL 2149
Query: 398 EEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQ 457
E +L L L A+ +E ++ V+ K +L LE+
Sbjct: 2150 EFRVRELEQAL----LVSADTFQKVED--RKHFGAVEAKPELSLEV-------------- 2189
Query: 458 QTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASV 517
+++ +RD++ + + E L+ ++L + EVQQL
Sbjct: 2190 -----QLQAERDAIDRK-----------EKEITNLEEQLEQFREELENKNEEVQQLH--- 2230
Query: 518 KNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN------KEIEAARRQFQ 571
M+ ++ E +L+ ++ENK+ KD+M KE +A Q Q
Sbjct: 2231 --------------MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ 2276
Query: 572 SQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA---IISDLRSRVRD 621
L + I++ E ++ + +Q+ +++ + +T +I + +RD
Sbjct: 2277 HVL--FGKFAQIIQEKEVEIDQLNEQVTKLQQQ-LKITTDNKVIEEKNELIRD 2326
Score = 65.1 bits (157), Expect = 2e-10
Identities = 117/552 (21%), Positives = 231/552 (41%), Gaps = 65/552 (11%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEV---AHELAETEHE 156
K+ DK + L + E+K K E +K+ + EE++++ EL + H+
Sbjct: 351 KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
Query: 157 NTVLRHNI-ERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGK 215
++ +I +RM++E T + + L+ E + + + + +M + + +++ +
Sbjct: 411 DSQFETDIVQRMEQE---TQRKLEQLRAELDEMYGQQI-VQMKQELIRQHMAQMEEMKTR 466
Query: 216 LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDL-LREQHCKEDSERLMEQQGAL 274
K E + + +T ++ + E N L+D +++ KE+ ++E++ AL
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 275 LKRLAEADSE---------KARLLLLLQD-KDKEVEELLQEIQCEKAQAKTASELSKSME 324
++L + E +AR + Q+ K E + L ++ KA+ +ASE K +E
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE 586
Query: 325 SMRG----HLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL----KELKQKG 376
+ + +L E E + + L+R +AE+E + QL +E K
Sbjct: 587 LKHEAEVTNYKIKLEMLEKEKNAV------LDRMAESQEAELERLRTQLLFSHEEELSKL 640
Query: 377 DRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEK 436
D E ++ I +K + Y +Q+ D E +E+ + + ++ ++
Sbjct: 641 KEDLE-IEHRINIEKLKDNLGIHYKQQI-------DGLQNEMSQKIETMQFEKDNLITKQ 692
Query: 437 GDLELEIIVLNDRVTDLVN---QQQTLE--EKMREDRDSLVERLHRQTAEYSAFKLE--- 488
L LEI L D LVN ++ TL+ E +E E + T E +L+
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 489 ---NERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRL--------- 536
+++K +++K Q E LK K E M+ + + RL
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
Query: 537 EADEV-AAQLERCDKENKILKD---EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLA 592
D V ++E +EN+ LK ++N+EIE R F + + L+ A L
Sbjct: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872
Query: 593 ECQDQLQGYERK 604
+ +D L+ + K
Sbjct: 873 KVKDDLEDSKNK 884
Score = 62.8 bits (151), Expect = 9e-10
Identities = 115/520 (22%), Positives = 223/520 (42%), Gaps = 85/520 (16%)
Query: 104 YDKKIDSLMNAVG------CLKSEVKMQKGE----RQMAKRFLEERKEELEEVAHELAET 153
+ KKI L+ AV +E GE +Q+++ +LEERK + ++
Sbjct: 2939 FPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTIS------ 2992
Query: 154 EHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSK----LVEAEMDGAAAAKQVMAL 209
++ + + ++R E D + + E L++ L E + AA ++ AL
Sbjct: 2993 SLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTAL 3052
Query: 210 --KDTIGKLKTEKQ---------MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQ 258
D +G L +Q + ++ LL + + + N L REQ
Sbjct: 3053 GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ 3112
Query: 259 HCKEDSERLME-----QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQA 313
++ S+ L+E +Q +L+ E S K R L + E + ++ E++ E AQ
Sbjct: 3113 ESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE-KMVVAELKSELAQT 3171
Query: 314 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLE--------RSGNQHKAEVEAI 365
K EL ++++ HL KE E RL ++ K E S + E++
Sbjct: 3172 KL--ELETTLKAQHKHL------KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3223
Query: 366 MEQLK-ELKQKGDRDKESL---KKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALST 421
+E+ K +L + +RDKE L K ++ +QK+R QL++ L + + E+
Sbjct: 3224 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL-------QLNLLLEQQKQLLNESQQK 3276
Query: 422 LESWRSRYN-QVVKEKG-DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQT 479
+ES R Y+ Q+ +E+G +LEL++++ +++V + + + ++ RE LH Q
Sbjct: 3277 IESQRMLYDAQLSEEQGRNLELQVLLESEKVR--IREMSSTLDRERE--------LHAQL 3326
Query: 480 AEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEAD 539
L P ED L + ++++ + + + YK ++TR + +
Sbjct: 3327 QSSDGTGQSRPPL-----PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME 3381
Query: 540 EVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQ 579
+ + ++ + E N E + + QS++ DLQ+
Sbjct: 3382 KD----RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR 3417
Score = 42.0 bits (97), Expect = 0.002
Identities = 103/514 (20%), Positives = 191/514 (37%), Gaps = 84/514 (16%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L ++K + GE ++ K+E E+V+ E E ++ HN + D Q
Sbjct: 962 LSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---IIINHNRAENVQSCD---TQ 1015
Query: 178 KKHLQQEKECLMSKLVE---AEMDGAAAAKQVMALKD-------TIGKLKTEKQMTCTDI 227
L + S+ E ++++ + + + ++D T+G+ ++Q+ +
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075
Query: 228 NTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKAR 287
++T++ L + S ++ + L L EQ+ D ME Q L + ++ R
Sbjct: 1076 PSVTKESSLRATQPSENDKLQKELNVLKSEQN---DLRLQMEAQRICLSLVYSTHVDQVR 1132
Query: 288 LLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQ 347
+ +KDK + L +E+ AQ + EL K
Sbjct: 1133 -EYMENEKDKALCSLKEELIF--AQEEKIKELQKI------------------------- 1164
Query: 348 IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ 407
H+ E++ + Q + GD K + QK +E+ + + L
Sbjct: 1165 ----------HQLELQTMKTQ-----ETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV 1209
Query: 408 LADKDLYVAEALSTLESWRSRYN--QVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMR 465
L + Y AL + + N + E D EL+ V D TL K+
Sbjct: 1210 LGE---YYTPALKCEVNAEDKENSGDYISENEDPELQ--DYRYEVQDFQENMHTLLNKVT 1264
Query: 466 EDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMID 525
E+ + L L QT + + + +K F E+ L + E + + + N E +
Sbjct: 1265 EEYNKL---LVLQTRLSKIWGQQTDGMKLEFG--EENLPKEETEFLSIHSQMTNLEDIDV 1319
Query: 526 NYKSQVM------KTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQ 579
N+KS++ KT+LE + + ++ + E N E E Q + Q
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST 1379
Query: 580 LPDILKITEAKLAECQDQLQGYE----RKNIDLT 609
+P L + + E Q Y +KNID T
Sbjct: 1380 VPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGT 1413
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/118 (24%), Positives = 60/118 (50%), Gaps = 3/118 (2%)
Query: 509 EVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ-LERCDKENKI-LKDEMNKEIEAA 566
++Q+ +A++K +G+I + + + R E DE + LE ++ K+ ++ + + E
Sbjct: 192 QLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETL 251
Query: 567 RRQFQSQLA-DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQ 623
R S A DL Q + + +L E L+ Y++K D T IS L+ +++ ++
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE 309
Score = 37.7 bits (86), Expect = 0.033
Identities = 95/475 (20%), Positives = 186/475 (39%), Gaps = 100/475 (21%)
Query: 128 ERQMAK--RFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 185
E++ AK R E KEELE++ L + N L +E+ K+ +L + + E
Sbjct: 3225 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ-----LLNESQQKIES 3279
Query: 186 ECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFE 245
+ ++ +E G QV+ L++EK +TL R++EL Q L + +
Sbjct: 3280 QRMLYDAQLSEEQGRNLELQVL--------LESEKVRIREMSSTLDRERELHAQ-LQSSD 3330
Query: 246 ETNRTLRDLLREQHCKEDSERLMEQQGALLKRL--------------------------- 278
T ++ L E KE ++L E+ +++ L
Sbjct: 3331 GTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390
Query: 279 ----AEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQ- 333
EA++E + + LQ K ++++ L+E ++ Q + ++ + Q Q
Sbjct: 3391 LQTEQEANTEGQKKMHELQSKVEDLQRQLEE---KRQQVYKLDLEGQRLQGIMQEFQKQE 3447
Query: 334 -LRSKEAENSRLCMQIKN--------LERSGN---QHKAE---VEAIMEQLKELKQKG-- 376
R ++ E+ R+ Q N +R+ N Q K E E+ +L E+ G
Sbjct: 3448 LEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTG 3507
Query: 377 -DRDKESLKKAIRAQKERAE-KSEEYAEQLHVQLADKDLYV------------------- 415
+ + E +++ ++ + + ++ +E+L + AD + ++
Sbjct: 3508 CNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ 3567
Query: 416 ----AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSL 471
+S S S +++++ +L I L + DL N LEE++R R +
Sbjct: 3568 QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTG 3627
Query: 472 VER-------LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKN 519
R L+ + E E ++ L +A EV +LKA ++N
Sbjct: 3628 AGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
Score = 29.6 bits (65), Expect = 8.9
Identities = 93/518 (17%), Positives = 201/518 (38%), Gaps = 96/518 (18%)
Query: 81 VSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERK 140
+ V S LS+ D + + ++++ L + + L+ ++K + + L++R
Sbjct: 1317 IDVNHKSKLSSLQD----LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372
Query: 141 EELEE--------------VAHELAETEHENTVLRHNIER---------MKEEKDFTILQ 177
+ + E + T + + ++ NI+ +KEE + L
Sbjct: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLL 1432
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
+K Q++ E ++K++ + A A+Q + + GK T ++Q +
Sbjct: 1433 EKQYQEQLEEEVAKVIVSM--SIAFAQQTELSRISGGKENTAS----------SKQAHAV 1480
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK 297
Q+ + + +D + Q + + E+ L K L E E +LL + D
Sbjct: 1481 CQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKE-----ILLSNSDP 1535
Query: 298 E------------VEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLC 345
EE+ + + + E+S S SM Q L ++ E+ R
Sbjct: 1536 HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS--SMDASRQLMLNEEQLEDMR-- 1591
Query: 346 MQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLH 405
+ ++ Q +E +Q + +++ + + Q+E E+ +E ++L+
Sbjct: 1592 -----------------QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634
Query: 406 VQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMR 465
QLA + E L + R +++E L+ + +++ + T +
Sbjct: 1635 RQLAQRSSIDNENLVS-----ERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
Query: 466 EDRDSLVER------LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASV-- 517
E++ + E+ L R+ + L NER A ++L + LEV + A+V
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKILLEVVKTTAAVEE 1747
Query: 518 ---KNYEGMID-NYKSQVMKTRLEADEVAAQLERCDKE 551
++ G++D + KSQ + + E A ++ C E
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE 1785
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 98.6 bits (244), Expect = 2e-20
Identities = 109/533 (20%), Positives = 240/533 (45%), Gaps = 67/533 (12%)
Query: 118 LKSEVKMQKGERQMAKRFLEERK--------EELEEVAHELAETEHENTVLRHNIERMKE 169
++SE+ ++ E + R LEE + ++L+E + + + T L N+++ +
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 170 EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT 229
EKD T+ + L ++ + L + + + A+ + T L KQ T
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQ---ASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
Query: 230 LTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLL 289
L Q LL E+ + D + ++ ++ E + K++ ++ E+
Sbjct: 277 LEEQDHLL-------EDYQKKKEDFTMQISFLQEKIKVYEMEQD--KKVENSNKEE---- 323
Query: 290 LLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK 349
+Q+K+ +EEL +I E+ + + + + + G LQ Q+ K E + +++
Sbjct: 324 --IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
Query: 350 NLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKE---------RAEKSEEY 400
N ++ Q E++ +M ++EL+++ +D + ++ ++ RAE E Y
Sbjct: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
Query: 401 AEQLHVQLADKDLYVAEALSTLESWRSR-----------YNQVVKEKGDLELEIIVLND- 448
+Q+ VQ+ K + + ++ +E ++R Y+ + + ++L + +N+
Sbjct: 442 GQQI-VQM--KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINEL 498
Query: 449 --RVTDLVNQQQTLEEKM---REDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL 503
++ D +Q++ L+E++ E++ +L +L E S + + +R + + A E KL
Sbjct: 499 NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
Query: 504 NQAHLE---VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN 560
N+AH V+ LKA + + ++ K +K E +LE +KE + D M
Sbjct: 559 NEAHKSLSTVEDLKAEIVSAS---ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA 615
Query: 561 KEIEAARRQFQSQL-----ADLQQLPDILKIT-EAKLAECQDQLQGYERKNID 607
+ EA + ++QL +L +L + L+I + + +D L + ++ ID
Sbjct: 616 ESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
Score = 79.3 bits (194), Expect = 1e-14
Identities = 120/547 (21%), Positives = 231/547 (42%), Gaps = 100/547 (18%)
Query: 128 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK--------- 178
E+ + +R ++E+ + ++ + EL + L ++++EE++ QK
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989
Query: 179 --KHLQQEKECLMSKLVEAEMDGAAA----AKQVMAL----KDTIGKLKTEKQMTCTDIN 228
+ L QE E LM + +E + KQV AL ++ + + +Q T++
Sbjct: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM 2049
Query: 229 TLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARL 288
L +Q + L ++L +R L EQ + ER + QQ +++L + R
Sbjct: 2050 DLRQQNQALEKQL-------EKMRKFLDEQAIDREHERDVFQQE--IQKLEQQLKVVPRF 2100
Query: 289 LLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQI 348
+ + + +EVE+L + K + SEL S E LQ ++ + E +L ++
Sbjct: 2101 QPISEHQTREVEQLANHL---KEKTDKCSELLLSKE----QLQRDIQERNEEIEKLEFRV 2153
Query: 349 KNLERS----GNQHKAEVEAIMEQLKELKQKGDRD----KE----SLKKAIRAQKERAEK 396
+ LE++ +H VEA E E++ + +RD KE +L++ + +E E
Sbjct: 2154 RELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2213
Query: 397 SEEYAEQLHVQLADKDLYVAEALSTLESWR-----------------------------S 427
E +QLH+QL + L LE
Sbjct: 2214 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2273
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQ-TLEEKMREDRDSLVERLHRQTAEYSAFK 486
++ Q+++EK E+EI LN++VT L Q + T + K+ E+++ L+ L Q
Sbjct: 2274 KFAQIIQEK---EVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQ---IECLM 2327
Query: 487 LENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLE 546
+ E +K + ++LN+ ++QQ A++ M + S+ EAD + QL
Sbjct: 2328 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE------EADSLKHQL- 2380
Query: 547 RCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNI 606
D + E A +Q ++ ++ + ++LK T K+ + +L +R+
Sbjct: 2381 ----------DVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2430
Query: 607 DLTAIIS 613
+ I S
Sbjct: 2431 SVEKIQS 2437
Score = 69.7 bits (169), Expect = 8e-12
Identities = 119/591 (20%), Positives = 240/591 (40%), Gaps = 125/591 (21%)
Query: 71 EITPPSSEKLVSVMRLSDLSTEDDDSGHCKM----NRYDKKIDSLMNAVGCLKSEVKMQK 126
++T +E ++R TE D M +R ++ L+ A+ S+++ K
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAK 1872
Query: 127 -GERQMAKRFLEERKEELEEVA--HELAETEHENTVLRHN--IERMKEE------KDFTI 175
+ ++ + +++E E + EL E HE + R +E K E D
Sbjct: 1873 VTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKT 1932
Query: 176 LQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKE 235
L ++ +Q EK ++ +L + +++ + + +L+ E+Q + L+RQKE
Sbjct: 1933 LFERQIQ-EKTDIIDRLEQ----------ELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 236 LLLQKLSTFE-----ETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
+ + E ET + +++ L Q E +++Q L+ + + + +R +
Sbjct: 1982 AMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALE--IDVEEQVSRFIE 2039
Query: 291 LLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKN 350
L Q+K+ E+ +L Q+ Q L K +E MR L Q +E E +I+
Sbjct: 2040 LEQEKNTELMDLRQQNQA----------LEKQLEKMRKFLDEQAIDREHERDVFQQEIQK 2089
Query: 351 LERS----------GNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEY 400
LE+ EVE + LKE K D+ E L + Q++ E++EE
Sbjct: 2090 LEQQLKVVPRFQPISEHQTREVEQLANHLKE---KTDKCSELLLSKEQLQRDIQERNEEI 2146
Query: 401 AE-QLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
+ + V+ ++ L V + ++ V+ K +L LE+
Sbjct: 2147 EKLEFRVRELEQALLVEDR---------KHFGAVEAKPELSLEV---------------- 2181
Query: 460 LEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKN 519
+++ +RD++ + + E L+ ++L + EVQQL
Sbjct: 2182 ---QLQAERDAIDRK-----------EKEITNLEEQLEQFREELENKNEEVQQLH----- 2222
Query: 520 YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN------KEIEAARRQFQSQ 573
M+ ++ E +L+ ++ENK+ KD+M KE +A Q Q
Sbjct: 2223 ------------MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2270
Query: 574 LADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA---IISDLRSRVRD 621
L + I++ E ++ + +Q+ +++ + +T +I + +RD
Sbjct: 2271 L--FGKFAQIIQEKEVEIDQLNEQVTKLQQQ-LKITTDNKVIEEKNELIRD 2318
Score = 65.1 bits (157), Expect = 2e-10
Identities = 117/552 (21%), Positives = 231/552 (41%), Gaps = 65/552 (11%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEV---AHELAETEHE 156
K+ DK + L + E+K K E +K+ + EE++++ EL + H+
Sbjct: 351 KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
Query: 157 NTVLRHNI-ERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGK 215
++ +I +RM++E T + + L+ E + + + + +M + + +++ +
Sbjct: 411 DSQFETDIVQRMEQE---TQRKLEQLRAELDEMYGQQI-VQMKQELIRQHMAQMEEMKTR 466
Query: 216 LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDL-LREQHCKEDSERLMEQQGAL 274
K E + + +T ++ + E N L+D +++ KE+ ++E++ AL
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 275 LKRLAEADSE---------KARLLLLLQD-KDKEVEELLQEIQCEKAQAKTASELSKSME 324
++L + E +AR + Q+ K E + L ++ KA+ +ASE K +E
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE 586
Query: 325 SMRG----HLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL----KELKQKG 376
+ + +L E E + + L+R +AE+E + QL +E K
Sbjct: 587 LKHEAEVTNYKIKLEMLEKEKNAV------LDRMAESQEAELERLRTQLLFSHEEELSKL 640
Query: 377 DRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEK 436
D E ++ I +K + Y +Q+ D E +E+ + + ++ ++
Sbjct: 641 KEDLE-IEHRINIEKLKDNLGIHYKQQI-------DGLQNEMSQKIETMQFEKDNLITKQ 692
Query: 437 GDLELEIIVLNDRVTDLVN---QQQTLE--EKMREDRDSLVERLHRQTAEYSAFKLE--- 488
L LEI L D LVN ++ TL+ E +E E + T E +L+
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 489 ---NERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRL--------- 536
+++K +++K Q E LK K E M+ + + RL
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
Query: 537 EADEV-AAQLERCDKENKILKD---EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLA 592
D V ++E +EN+ LK ++N+EIE R F + + L+ A L
Sbjct: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872
Query: 593 ECQDQLQGYERK 604
+ +D L+ + K
Sbjct: 873 KVKDDLEDSKNK 884
Score = 62.8 bits (151), Expect = 9e-10
Identities = 115/520 (22%), Positives = 223/520 (42%), Gaps = 85/520 (16%)
Query: 104 YDKKIDSLMNAVG------CLKSEVKMQKGE----RQMAKRFLEERKEELEEVAHELAET 153
+ KKI L+ AV +E GE +Q+++ +LEERK + ++
Sbjct: 2931 FPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTIS------ 2984
Query: 154 EHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSK----LVEAEMDGAAAAKQVMAL 209
++ + + ++R E D + + E L++ L E + AA ++ AL
Sbjct: 2985 SLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTAL 3044
Query: 210 --KDTIGKLKTEKQ---------MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQ 258
D +G L +Q + ++ LL + + + N L REQ
Sbjct: 3045 GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ 3104
Query: 259 HCKEDSERLME-----QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQA 313
++ S+ L+E +Q +L+ E S K R L + E + ++ E++ E AQ
Sbjct: 3105 ESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE-KMVVAELKSELAQT 3163
Query: 314 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLE--------RSGNQHKAEVEAI 365
K EL ++++ HL KE E RL ++ K E S + E++
Sbjct: 3164 KL--ELETTLKAQHKHL------KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3215
Query: 366 MEQLK-ELKQKGDRDKESL---KKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALST 421
+E+ K +L + +RDKE L K ++ +QK+R QL++ L + + E+
Sbjct: 3216 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL-------QLNLLLEQQKQLLNESQQK 3268
Query: 422 LESWRSRYN-QVVKEKG-DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQT 479
+ES R Y+ Q+ +E+G +LEL++++ +++V + + + ++ RE LH Q
Sbjct: 3269 IESQRMLYDAQLSEEQGRNLELQVLLESEKVR--IREMSSTLDRERE--------LHAQL 3318
Query: 480 AEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEAD 539
L P ED L + ++++ + + + YK ++TR + +
Sbjct: 3319 QSSDGTGQSRPPL-----PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME 3373
Query: 540 EVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQ 579
+ + ++ + E N E + + QS++ DLQ+
Sbjct: 3374 KD----RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR 3409
Score = 62.0 bits (149), Expect = 2e-09
Identities = 118/550 (21%), Positives = 219/550 (39%), Gaps = 89/550 (16%)
Query: 105 DKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEE---RKEELEEVAHELAETEHENTVLR 161
D+K + A L EV++Q ER R +E +E+LE+ EL E L
Sbjct: 2164 DRKHFGAVEAKPELSLEVQLQ-AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222
Query: 162 HNIERMKEEKDFTILQKKHLQQEKECL---MSKLVEAEMDGAAAAKQVMALKDTIGKLKT 218
+E K+E T LQ+ L+QE + M KL A + A + Q + GK
Sbjct: 2223 MQLEIQKKEST-TRLQE--LEQENKLFKDDMEKLGLAIKESDAMSTQDQHV--LFGKFAQ 2277
Query: 219 EKQMTCTDINTLTRQKELLLQKL------STFEETNRTLRDLLREQHCKEDSERLMEQQG 272
Q +I+ L Q L Q+L EE N +RDL + C LM Q
Sbjct: 2278 IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIEC------LMSDQ- 2330
Query: 273 ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI-QCEKAQAKTASELSKSMESMRGHLQ 331
+KR E + E+ ++ +E+L QE+ + + A LS+ +S++ L
Sbjct: 2331 ECVKRNREEEIEQL---------NEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLD 2381
Query: 332 AQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQK 391
+ K A LE+ E+ + LKE K ++ + L +++ ++
Sbjct: 2382 VVIAEKLA-----------LEQQVETANEEMTFMKNVLKETNFKMNQLTQEL-FSLKRER 2429
Query: 392 ERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVT 451
E EK + E V +A L K ELE+++ D +
Sbjct: 2430 ESVEKIQSIPEN-SVNVAIDHL---------------------SKDKPELEVVLTEDALK 2467
Query: 452 DLVNQQ--QTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE 509
L NQ ++ EE + +L RL + + SA LE L + ++D Q E
Sbjct: 2468 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE---LTQCYKQIKDMQEQGQFE 2524
Query: 510 VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKE---------------NKI 554
+ L+ + N + +++ + + ++++ + V + C N++
Sbjct: 2525 TEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL 2584
Query: 555 LKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISD 614
+DE+ +I A + + + ++ L + + ++ + + E+K ++L ++
Sbjct: 2585 REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2644
Query: 615 LRSRVRDWQK 624
+ R+ +K
Sbjct: 2645 NEKKQREKEK 2654
Score = 54.7 bits (130), Expect = 3e-07
Identities = 113/572 (19%), Positives = 244/572 (42%), Gaps = 75/572 (13%)
Query: 101 MNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVL 160
++R +K+I +L + + E++ + E Q LE +K+E L E E EN +
Sbjct: 2190 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT---RLQELEQENKLF 2246
Query: 161 RHNIERMK---EEKDFTILQKKHLQ--------QEKECLMSKL------VEAEMDGAAAA 203
+ ++E++ +E D Q +H+ QEKE + +L ++ ++
Sbjct: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306
Query: 204 KQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLS-TFEETNRTLRDL-----LRE 257
K + + I L+T+ + +D + R +E +++L+ E+ + L ++ +
Sbjct: 2307 KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNA 2366
Query: 258 QHCKEDSERLMEQQG-------ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEK 310
E+++ L Q AL +++ A+ E + +L++ + ++ +L QE+ K
Sbjct: 2367 HSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLK 2426
Query: 311 AQAKTASELSKSMESMRG----HLQAQ------------LRSKE--------AENSR--- 343
+ ++ ++ E+ HL L+S E EN +
Sbjct: 2427 RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI 2486
Query: 344 --LCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESL-KKAIRAQKERAEK-SEE 399
L ++ LE + + E+ +Q+K+++++G + E L KK + QK EK +
Sbjct: 2487 INLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA 2546
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYN-QVVKEKGDLEL--EIIVLNDRVTDLVNQ 456
Q+ ++ + + T+ S R N Q + + + EL +I L R+++L +Q
Sbjct: 2547 LVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQ 2606
Query: 457 QQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKA--SFAPMEDKLNQAHLEVQQLK 514
+ + +++ VE + E LE ++L E + ++ +V+ LK
Sbjct: 2607 VVEMHTSLILEKEQ-VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665
Query: 515 ASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL 574
+ + + ++ ++ L A+ VA + E + K +++ +E+ S
Sbjct: 2666 TTTELFHSNEESGFFNELEA-LRAESVATKAELASYKEK--AEKLQEELLVKETNMTSLQ 2722
Query: 575 ADLQQLPDILKITEAKLA--ECQDQLQGYERK 604
DL Q+ D L + KL+ E +D+ + E K
Sbjct: 2723 KDLSQVRDHLAEAKEKLSILEKEDETEVQESK 2754
Score = 42.0 bits (97), Expect = 0.002
Identities = 103/514 (20%), Positives = 191/514 (37%), Gaps = 84/514 (16%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L ++K + GE ++ K+E E+V+ E E ++ HN + D Q
Sbjct: 962 LSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---IIINHNRAENVQSCD---TQ 1015
Query: 178 KKHLQQEKECLMSKLVE---AEMDGAAAAKQVMALKD-------TIGKLKTEKQMTCTDI 227
L + S+ E ++++ + + + ++D T+G+ ++Q+ +
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075
Query: 228 NTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKAR 287
++T++ L + S ++ + L L EQ+ D ME Q L + ++ R
Sbjct: 1076 PSVTKESSLRATQPSENDKLQKELNVLKSEQN---DLRLQMEAQRICLSLVYSTHVDQVR 1132
Query: 288 LLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQ 347
+ +KDK + L +E+ AQ + EL K
Sbjct: 1133 -EYMENEKDKALCSLKEELIF--AQEEKIKELQKI------------------------- 1164
Query: 348 IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ 407
H+ E++ + Q + GD K + QK +E+ + + L
Sbjct: 1165 ----------HQLELQTMKTQ-----ETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV 1209
Query: 408 LADKDLYVAEALSTLESWRSRYN--QVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMR 465
L + Y AL + + N + E D EL+ V D TL K+
Sbjct: 1210 LGE---YYTPALKCEVNAEDKENSGDYISENEDPELQ--DYRYEVQDFQENMHTLLNKVT 1264
Query: 466 EDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMID 525
E+ + L L QT + + + +K F E+ L + E + + + N E +
Sbjct: 1265 EEYNKL---LVLQTRLSKIWGQQTDGMKLEFG--EENLPKEETEFLSIHSQMTNLEDIDV 1319
Query: 526 NYKSQVM------KTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQ 579
N+KS++ KT+LE + + ++ + E N E E Q + Q
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST 1379
Query: 580 LPDILKITEAKLAECQDQLQGYE----RKNIDLT 609
+P L + + E Q Y +KNID T
Sbjct: 1380 VPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGT 1413
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/118 (24%), Positives = 60/118 (50%), Gaps = 3/118 (2%)
Query: 509 EVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ-LERCDKENKI-LKDEMNKEIEAA 566
++Q+ +A++K +G+I + + + R E DE + LE ++ K+ ++ + + E
Sbjct: 192 QLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETL 251
Query: 567 RRQFQSQLA-DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQ 623
R S A DL Q + + +L E L+ Y++K D T IS L+ +++ ++
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE 309
Score = 37.7 bits (86), Expect = 0.033
Identities = 95/475 (20%), Positives = 186/475 (39%), Gaps = 100/475 (21%)
Query: 128 ERQMAK--RFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 185
E++ AK R E KEELE++ L + N L +E+ K+ +L + + E
Sbjct: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ-----LLNESQQKIES 3271
Query: 186 ECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFE 245
+ ++ +E G QV+ L++EK +TL R++EL Q L + +
Sbjct: 3272 QRMLYDAQLSEEQGRNLELQVL--------LESEKVRIREMSSTLDRERELHAQ-LQSSD 3322
Query: 246 ETNRTLRDLLREQHCKEDSERLMEQQGALLKRL--------------------------- 278
T ++ L E KE ++L E+ +++ L
Sbjct: 3323 GTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382
Query: 279 ----AEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQ- 333
EA++E + + LQ K ++++ L+E ++ Q + ++ + Q Q
Sbjct: 3383 LQTEQEANTEGQKKMHELQSKVEDLQRQLEE---KRQQVYKLDLEGQRLQGIMQEFQKQE 3439
Query: 334 -LRSKEAENSRLCMQIKN--------LERSGN---QHKAE---VEAIMEQLKELKQKG-- 376
R ++ E+ R+ Q N +R+ N Q K E E+ +L E+ G
Sbjct: 3440 LEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTG 3499
Query: 377 -DRDKESLKKAIRAQKERAE-KSEEYAEQLHVQLADKDLYV------------------- 415
+ + E +++ ++ + + ++ +E+L + AD + ++
Sbjct: 3500 CNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ 3559
Query: 416 ----AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSL 471
+S S S +++++ +L I L + DL N LEE++R R +
Sbjct: 3560 QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTG 3619
Query: 472 VER-------LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKN 519
R L+ + E E ++ L +A EV +LKA ++N
Sbjct: 3620 AGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674
Score = 29.6 bits (65), Expect = 8.9
Identities = 93/518 (17%), Positives = 201/518 (38%), Gaps = 96/518 (18%)
Query: 81 VSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERK 140
+ V S LS+ D + + ++++ L + + L+ ++K + + L++R
Sbjct: 1317 IDVNHKSKLSSLQD----LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372
Query: 141 EELEE--------------VAHELAETEHENTVLRHNIER---------MKEEKDFTILQ 177
+ + E + T + + ++ NI+ +KEE + L
Sbjct: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLL 1432
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
+K Q++ E ++K++ + A A+Q + + GK T ++Q +
Sbjct: 1433 EKQYQEQLEEEVAKVIVSM--SIAFAQQTELSRISGGKENTAS----------SKQAHAV 1480
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK 297
Q+ + + +D + Q + + E+ L K L E E +LL + D
Sbjct: 1481 CQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKE-----ILLSNSDP 1535
Query: 298 E------------VEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLC 345
EE+ + + + E+S S SM Q L ++ E+ R
Sbjct: 1536 HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS--SMDASRQLMLNEEQLEDMR-- 1591
Query: 346 MQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLH 405
+ ++ Q +E +Q + +++ + + Q+E E+ +E ++L+
Sbjct: 1592 -----------------QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634
Query: 406 VQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMR 465
QLA + E L + R +++E L+ + +++ + T +
Sbjct: 1635 RQLAQRSSIDNENLVS-----ERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
Query: 466 EDRDSLVER------LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASV-- 517
E++ + E+ L R+ + L NER A ++L + LEV + A+V
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKILLEVVKTTAAVEE 1747
Query: 518 ---KNYEGMID-NYKSQVMKTRLEADEVAAQLERCDKE 551
++ G++D + KSQ + + E A ++ C E
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE 1785
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 97.4 bits (241), Expect = 3e-20
Identities = 112/524 (21%), Positives = 219/524 (41%), Gaps = 55/524 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 896 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 282
+K + ++ E + E Q+ LKR E D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 283 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 341
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 342 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 398
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 399 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQ 458
+ Q H Q V E LE ++ + K K LE E L + L +Q
Sbjct: 1195 QEMRQKHAQA------VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 459 TLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+E K + +L Q E + + ER +A + DK V +L+ V+
Sbjct: 1249 EVEHKKK--------KLEAQVQELQSKCSDGERARAE---LNDK-------VHKLQNEVE 1290
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ GM++ + + +K + +++QL+ ++L++E +++ + + L+
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK--------LR 1339
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDW 622
QL + + +L E + Q ER L +SD + +++D+
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Score = 89.7 bits (221), Expect = 7e-18
Identities = 99/496 (19%), Positives = 225/496 (45%), Gaps = 42/496 (8%)
Query: 136 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 191
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 192 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 249
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1450 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 250 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 309
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1508 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 310 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 369
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1559 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1611
Query: 370 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 425
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 426 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 485
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1727
Query: 486 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 545
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 546 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 605
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1837
Query: 606 IDLTAIISDLRSRVRD 621
T + ++++
Sbjct: 1838 QAATKSLKQKDKKLKE 1853
Score = 89.0 bits (219), Expect = 1e-17
Identities = 113/511 (22%), Positives = 227/511 (44%), Gaps = 49/511 (9%)
Query: 139 RKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQ-QEKECLMSKLVEAEM 197
++EE++ EL +T+ + K E + L++KH Q E++ L+ + ++AE
Sbjct: 850 QEEEMQAKEDELQKTKE---------RQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 198 DGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLRE 257
+ A A++ ++ + K E + ++ ++E Q+L E + + +L
Sbjct: 901 ELYAEAEE---MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA--ERKKMAQQMLDL 955
Query: 258 QHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDK------------DKEVEELLQE 305
+ E+ E Q+ L K AEA +K +L+ D ++ + +L
Sbjct: 956 EEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 306 IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 365
+ E+ +AK ++L ESM L+ +L+ +E L + LE + ++ +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 366 MEQLKELKQKGDRDKESLKKAI-RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 424
Q+ ELK + + +E L+ A+ R E A+K+ ++ + + ++++ L+S
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-----KIRELEGHISDLQEDLDS 1129
Query: 425 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 484
R+ N+ K+K DL E+ L + D ++ T ++++R R+ V L + E
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE--- 1185
Query: 485 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 544
E +A M K QA E+ + K + +D K + K E ++A +
Sbjct: 1186 ---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE 1239
Query: 545 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQ----QLPDILKITEAKLAECQDQLQG 600
L R + K + K++EA ++ QS+ +D + +L D + + ++ L
Sbjct: 1240 L-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 601 YERKNIDLTAIISDLRSRVRDWQKGSHELTR 631
E K I L ++ L S+++D Q+ E TR
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Score = 85.1 bits (209), Expect = 2e-16
Identities = 119/548 (21%), Positives = 230/548 (41%), Gaps = 46/548 (8%)
Query: 95 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 154
D + N KKI L + L+ ++ ++ R A++ + EELE + EL +T
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT- 1158
Query: 155 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALK 210
++T + + R K E++ T+L KK L +E +++ E A A +Q+ K
Sbjct: 1159 LDSTATQQEL-RAKREQEVTVL-KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSER--- 266
L KQ + L + +L Q E + L ++E K D ER
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 267 --------LMEQQGALLKRLAEADSEKARL---LLLLQDKDKEVEELLQEIQCEKAQAKT 315
L + ++ L EA+ + +L + L + ++ +ELLQE E Q
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE---ETRQKLN 1333
Query: 316 ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK--NLERSGNQHK-AEVEAIMEQLKEL 372
S + +E R LQ QL + L I N++ S ++ K + + +E L+E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 373 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYV---AEALSTLESWRSRY 429
K++ ++ E+L + + +K E+ +L +L D + + + +S LE + ++
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 430 NQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLEN 489
+Q++ E+ ++ + DR +++T SL L + N
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKET-------KALSLARALEEALEAKEELERTN 1506
Query: 490 ERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD 549
+ LKA + + V +L+ S + E ++ K+Q+ + E R +
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 550 KENKILKDEMNKEIEA-------ARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYE 602
+ LK + ++++A RRQ Q QL + + + + A A + +L+G +
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG-D 1625
Query: 603 RKNIDLTA 610
K+++L A
Sbjct: 1626 LKDLELQA 1633
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/513 (21%), Positives = 194/513 (37%), Gaps = 58/513 (11%)
Query: 86 LSDLSTEDDDSGHCKMN--RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERK--- 140
L DL + D+ N + +K D L+ + S+ ++ + R E +
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 141 -EELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDG 199
LEE E E N +L+ +E + KD L++ K L +++ E +
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 200 AAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQ 258
++ A +D KL+ E M L Q E LQ + EE R L+ L E
Sbjct: 1549 EELEDELQATEDA--KLRLEVNM-----QALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 259 HCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE 318
+ + ER A K+ E D KD E LQ K + + +
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDL-----------KDLE----LQADSAIKGREEAIKQ 1646
Query: 319 LSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQK 375
L K M+ Q +L A + K E+ +A++ + E L + +++
Sbjct: 1647 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 376 GDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE 435
D +KE L + + + ++ +L ++A + + E +E+ R + ++
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 436 KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKAS 495
L E+ + +Q LE + +E R L E + A S FK L+A
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM---EGAVKSKFKSTIAALEAK 1822
Query: 496 FAPMEDKLNQAHLEVQQLKASVKNYEG--------------MIDNYKSQVMKTRLEADEV 541
A +E+++ Q E Q S+K + M + YK Q K ++
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 542 AAQLERCDKENKILKDEMNKEIEAARRQFQSQL 574
QLE ++E ++ I A RR+ Q +L
Sbjct: 1883 KRQLEEAEEE--------SQRINANRRKLQREL 1907
Score = 77.8 bits (190), Expect = 3e-14
Identities = 103/479 (21%), Positives = 201/479 (41%), Gaps = 56/479 (11%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 155
++ R +K + + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 156 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDGAAAAKQVMALKDT 212
L N++ +K + + + + +EK + + + E E++ + + A
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA--- 1617
Query: 213 IGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQG 272
K K E + K+L LQ S + ++ L + Q +D +R +E
Sbjct: 1618 -AKKKLEGDL-----------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 273 ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA-SELSKSMESMRGHLQ 331
A + E + K K +E L ++Q + A A+ A + E + L
Sbjct: 1666 ASRDEIFATAKENEK-------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 332 AQLRSKEA---ENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR 388
+ L + A E RL +I LE + + +EA+ +++++ Q+ E L +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA----EQLSNELA 1774
Query: 389 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLE-SWRSRYNQVVKEKGDLELEIIVLN 447
++ A+K+E +QL Q +K+L L +E + +S++ + LE +I L
Sbjct: 1775 TERSTAQKNESARQQLERQ--NKEL--RSKLHEMEGAVKSKFKSTIAA---LEAKIAQLE 1827
Query: 448 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 507
++V ++Q + +++ L E L ++E+ER A +++ + +
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEIL---------LQVEDERKMAE--QYKEQAEKGN 1876
Query: 508 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAA 566
V+QLK ++ E + K + E DE E +E LK ++ + E +
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935
Score = 63.9 bits (154), Expect = 4e-10
Identities = 73/312 (23%), Positives = 136/312 (43%), Gaps = 36/312 (11%)
Query: 123 KMQKGERQMA--KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH 180
+++K + QM +R LE+ + +E+ E E + L ++ +++E+ +K
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 181 LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL-------TRQ 233
EKE L +L + A + L+ I +L+ E + ++ + T+Q
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 234 KELLLQKLSTFEET---NRTLRDLLREQHCKEDSERLMEQQGA----------------- 273
E L +L+T T N + R L Q+ KE +L E +GA
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 274 -LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQA 332
L +++ + EK L+ KDK+++E+L +++ E+ A+ E ++ + L+
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 333 QLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKE-----SLKKAI 387
QL E E+ R+ + L+R ++ EA+ ++ LK K R E S +
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1944
Query: 388 RAQKERAEKSEE 399
R E A+ SEE
Sbjct: 1945 RRVIENADGSEE 1956
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 97.4 bits (241), Expect = 3e-20
Identities = 112/524 (21%), Positives = 219/524 (41%), Gaps = 55/524 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 903 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 282
+K + ++ E + E Q+ LKR E D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 283 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 341
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 342 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 398
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 399 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQ 458
+ Q H Q V E LE ++ + K K LE E L + L +Q
Sbjct: 1202 QEMRQKHAQA------VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 459 TLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+E K + +L Q E + + ER +A + DK V +L+ V+
Sbjct: 1256 EVEHKKK--------KLEAQVQELQSKCSDGERARAE---LNDK-------VHKLQNEVE 1297
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ GM++ + + +K + +++QL+ ++L++E +++ + + L+
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK--------LR 1346
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDW 622
QL + + +L E + Q ER L +SD + +++D+
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Score = 89.7 bits (221), Expect = 7e-18
Identities = 99/496 (19%), Positives = 225/496 (45%), Gaps = 42/496 (8%)
Query: 136 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 191
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 192 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 249
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1457 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 250 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 309
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1515 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 310 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 369
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1566 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1618
Query: 370 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 425
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 426 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 485
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1734
Query: 486 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 545
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 546 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 605
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1844
Query: 606 IDLTAIISDLRSRVRD 621
T + ++++
Sbjct: 1845 QAATKSLKQKDKKLKE 1860
Score = 89.0 bits (219), Expect = 1e-17
Identities = 113/511 (22%), Positives = 227/511 (44%), Gaps = 49/511 (9%)
Query: 139 RKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQ-QEKECLMSKLVEAEM 197
++EE++ EL +T+ + K E + L++KH Q E++ L+ + ++AE
Sbjct: 857 QEEEMQAKEDELQKTKE---------RQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 198 DGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLRE 257
+ A A++ ++ + K E + ++ ++E Q+L E + + +L
Sbjct: 908 ELYAEAEE---MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA--ERKKMAQQMLDL 962
Query: 258 QHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDK------------DKEVEELLQE 305
+ E+ E Q+ L K AEA +K +L+ D ++ + +L
Sbjct: 963 EEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 306 IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 365
+ E+ +AK ++L ESM L+ +L+ +E L + LE + ++ +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 366 MEQLKELKQKGDRDKESLKKAI-RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 424
Q+ ELK + + +E L+ A+ R E A+K+ ++ + + ++++ L+S
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-----KIRELEGHISDLQEDLDS 1136
Query: 425 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 484
R+ N+ K+K DL E+ L + D ++ T ++++R R+ V L + E
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE--- 1192
Query: 485 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 544
E +A M K QA E+ + K + +D K + K E ++A +
Sbjct: 1193 ---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE 1246
Query: 545 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQ----QLPDILKITEAKLAECQDQLQG 600
L R + K + K++EA ++ QS+ +D + +L D + + ++ L
Sbjct: 1247 L-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 601 YERKNIDLTAIISDLRSRVRDWQKGSHELTR 631
E K I L ++ L S+++D Q+ E TR
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Score = 85.1 bits (209), Expect = 2e-16
Identities = 119/548 (21%), Positives = 230/548 (41%), Gaps = 46/548 (8%)
Query: 95 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 154
D + N KKI L + L+ ++ ++ R A++ + EELE + EL +T
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT- 1165
Query: 155 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALK 210
++T + + R K E++ T+L KK L +E +++ E A A +Q+ K
Sbjct: 1166 LDSTATQQEL-RAKREQEVTVL-KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSER--- 266
L KQ + L + +L Q E + L ++E K D ER
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 267 --------LMEQQGALLKRLAEADSEKARL---LLLLQDKDKEVEELLQEIQCEKAQAKT 315
L + ++ L EA+ + +L + L + ++ +ELLQE E Q
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE---ETRQKLN 1340
Query: 316 ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK--NLERSGNQHK-AEVEAIMEQLKEL 372
S + +E R LQ QL + L I N++ S ++ K + + +E L+E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 373 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYV---AEALSTLESWRSRY 429
K++ ++ E+L + + +K E+ +L +L D + + + +S LE + ++
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 430 NQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLEN 489
+Q++ E+ ++ + DR +++T SL L + N
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKET-------KALSLARALEEALEAKEELERTN 1513
Query: 490 ERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD 549
+ LKA + + V +L+ S + E ++ K+Q+ + E R +
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 550 KENKILKDEMNKEIEA-------ARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYE 602
+ LK + ++++A RRQ Q QL + + + + A A + +L+G +
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG-D 1632
Query: 603 RKNIDLTA 610
K+++L A
Sbjct: 1633 LKDLELQA 1640
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/513 (21%), Positives = 194/513 (37%), Gaps = 58/513 (11%)
Query: 86 LSDLSTEDDDSGHCKMN--RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERK--- 140
L DL + D+ N + +K D L+ + S+ ++ + R E +
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 141 -EELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDG 199
LEE E E N +L+ +E + KD L++ K L +++ E +
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 200 AAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQ 258
++ A +D KL+ E M L Q E LQ + EE R L+ L E
Sbjct: 1556 EELEDELQATEDA--KLRLEVNM-----QALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 259 HCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE 318
+ + ER A K+ E D KD E LQ K + + +
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDL-----------KDLE----LQADSAIKGREEAIKQ 1653
Query: 319 LSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQK 375
L K M+ Q +L A + K E+ +A++ + E L + +++
Sbjct: 1654 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 376 GDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE 435
D +KE L + + + ++ +L ++A + + E +E+ R + ++
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 436 KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKAS 495
L E+ + +Q LE + +E R L E + A S FK L+A
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM---EGAVKSKFKSTIAALEAK 1829
Query: 496 FAPMEDKLNQAHLEVQQLKASVKNYEG--------------MIDNYKSQVMKTRLEADEV 541
A +E+++ Q E Q S+K + M + YK Q K ++
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 542 AAQLERCDKENKILKDEMNKEIEAARRQFQSQL 574
QLE ++E ++ I A RR+ Q +L
Sbjct: 1890 KRQLEEAEEE--------SQRINANRRKLQREL 1914
Score = 77.8 bits (190), Expect = 3e-14
Identities = 103/479 (21%), Positives = 201/479 (41%), Gaps = 56/479 (11%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 155
++ R +K + + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 156 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDGAAAAKQVMALKDT 212
L N++ +K + + + + +EK + + + E E++ + + A
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA--- 1624
Query: 213 IGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQG 272
K K E + K+L LQ S + ++ L + Q +D +R +E
Sbjct: 1625 -AKKKLEGDL-----------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 273 ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA-SELSKSMESMRGHLQ 331
A + E + K K +E L ++Q + A A+ A + E + L
Sbjct: 1673 ASRDEIFATAKENEK-------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 332 AQLRSKEA---ENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR 388
+ L + A E RL +I LE + + +EA+ +++++ Q+ E L +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA----EQLSNELA 1781
Query: 389 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLE-SWRSRYNQVVKEKGDLELEIIVLN 447
++ A+K+E +QL Q +K+L L +E + +S++ + LE +I L
Sbjct: 1782 TERSTAQKNESARQQLERQ--NKEL--RSKLHEMEGAVKSKFKSTIAA---LEAKIAQLE 1834
Query: 448 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 507
++V ++Q + +++ L E L ++E+ER A +++ + +
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEIL---------LQVEDERKMAE--QYKEQAEKGN 1883
Query: 508 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAA 566
V+QLK ++ E + K + E DE E +E LK ++ + E +
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942
Score = 63.9 bits (154), Expect = 4e-10
Identities = 73/312 (23%), Positives = 136/312 (43%), Gaps = 36/312 (11%)
Query: 123 KMQKGERQMA--KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH 180
+++K + QM +R LE+ + +E+ E E + L ++ +++E+ +K
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 181 LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL-------TRQ 233
EKE L +L + A + L+ I +L+ E + ++ + T+Q
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 234 KELLLQKLSTFEET---NRTLRDLLREQHCKEDSERLMEQQGA----------------- 273
E L +L+T T N + R L Q+ KE +L E +GA
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 274 -LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQA 332
L +++ + EK L+ KDK+++E+L +++ E+ A+ E ++ + L+
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 333 QLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKE-----SLKKAI 387
QL E E+ R+ + L+R ++ EA+ ++ LK K R E S +
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1951
Query: 388 RAQKERAEKSEE 399
R E A+ SEE
Sbjct: 1952 RRVIENADGSEE 1963
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 97.4 bits (241), Expect = 3e-20
Identities = 112/524 (21%), Positives = 219/524 (41%), Gaps = 55/524 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 903 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 282
+K + ++ E + E Q+ LKR E D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 283 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 341
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 342 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 398
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 399 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQ 458
+ Q H Q V E LE ++ + K K LE E L + L +Q
Sbjct: 1202 QEMRQKHAQA------VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 459 TLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+E K + +L Q E + + ER +A + DK V +L+ V+
Sbjct: 1256 EVEHKKK--------KLEAQVQELQSKCSDGERARAE---LNDK-------VHKLQNEVE 1297
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ GM++ + + +K + +++QL+ ++L++E +++ + + L+
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK--------LR 1346
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDW 622
QL + + +L E + Q ER L +SD + +++D+
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Score = 89.7 bits (221), Expect = 7e-18
Identities = 99/496 (19%), Positives = 225/496 (45%), Gaps = 42/496 (8%)
Query: 136 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 191
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 192 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 249
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1457 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 250 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 309
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1515 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 310 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 369
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1566 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1618
Query: 370 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 425
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 426 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 485
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1734
Query: 486 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 545
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 546 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 605
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1844
Query: 606 IDLTAIISDLRSRVRD 621
T + ++++
Sbjct: 1845 QAATKSLKQKDKKLKE 1860
Score = 89.0 bits (219), Expect = 1e-17
Identities = 113/511 (22%), Positives = 227/511 (44%), Gaps = 49/511 (9%)
Query: 139 RKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQ-QEKECLMSKLVEAEM 197
++EE++ EL +T+ + K E + L++KH Q E++ L+ + ++AE
Sbjct: 857 QEEEMQAKEDELQKTKE---------RQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 198 DGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLRE 257
+ A A++ ++ + K E + ++ ++E Q+L E + + +L
Sbjct: 908 ELYAEAEE---MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA--ERKKMAQQMLDL 962
Query: 258 QHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDK------------DKEVEELLQE 305
+ E+ E Q+ L K AEA +K +L+ D ++ + +L
Sbjct: 963 EEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 306 IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 365
+ E+ +AK ++L ESM L+ +L+ +E L + LE + ++ +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 366 MEQLKELKQKGDRDKESLKKAI-RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 424
Q+ ELK + + +E L+ A+ R E A+K+ ++ + + ++++ L+S
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-----KIRELEGHISDLQEDLDS 1136
Query: 425 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 484
R+ N+ K+K DL E+ L + D ++ T ++++R R+ V L + E
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE--- 1192
Query: 485 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 544
E +A M K QA E+ + K + +D K + K E ++A +
Sbjct: 1193 ---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE 1246
Query: 545 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQ----QLPDILKITEAKLAECQDQLQG 600
L R + K + K++EA ++ QS+ +D + +L D + + ++ L
Sbjct: 1247 L-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 601 YERKNIDLTAIISDLRSRVRDWQKGSHELTR 631
E K I L ++ L S+++D Q+ E TR
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Score = 85.1 bits (209), Expect = 2e-16
Identities = 119/548 (21%), Positives = 230/548 (41%), Gaps = 46/548 (8%)
Query: 95 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 154
D + N KKI L + L+ ++ ++ R A++ + EELE + EL +T
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT- 1165
Query: 155 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALK 210
++T + + R K E++ T+L KK L +E +++ E A A +Q+ K
Sbjct: 1166 LDSTATQQEL-RAKREQEVTVL-KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSER--- 266
L KQ + L + +L Q E + L ++E K D ER
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 267 --------LMEQQGALLKRLAEADSEKARL---LLLLQDKDKEVEELLQEIQCEKAQAKT 315
L + ++ L EA+ + +L + L + ++ +ELLQE E Q
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE---ETRQKLN 1340
Query: 316 ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK--NLERSGNQHK-AEVEAIMEQLKEL 372
S + +E R LQ QL + L I N++ S ++ K + + +E L+E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 373 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYV---AEALSTLESWRSRY 429
K++ ++ E+L + + +K E+ +L +L D + + + +S LE + ++
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 430 NQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLEN 489
+Q++ E+ ++ + DR +++T SL L + N
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKET-------KALSLARALEEALEAKEELERTN 1513
Query: 490 ERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD 549
+ LKA + + V +L+ S + E ++ K+Q+ + E R +
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 550 KENKILKDEMNKEIEA-------ARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYE 602
+ LK + ++++A RRQ Q QL + + + + A A + +L+G +
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG-D 1632
Query: 603 RKNIDLTA 610
K+++L A
Sbjct: 1633 LKDLELQA 1640
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/513 (21%), Positives = 194/513 (37%), Gaps = 58/513 (11%)
Query: 86 LSDLSTEDDDSGHCKMN--RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERK--- 140
L DL + D+ N + +K D L+ + S+ ++ + R E +
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 141 -EELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDG 199
LEE E E N +L+ +E + KD L++ K L +++ E +
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Query: 200 AAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQ 258
++ A +D KL+ E M L Q E LQ + EE R L+ L E
Sbjct: 1556 EELEDELQATEDA--KLRLEVNM-----QALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 259 HCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE 318
+ + ER A K+ E D KD E LQ K + + +
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDL-----------KDLE----LQADSAIKGREEAIKQ 1653
Query: 319 LSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQK 375
L K M+ Q +L A + K E+ +A++ + E L + +++
Sbjct: 1654 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 376 GDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE 435
D +KE L + + + ++ +L ++A + + E +E+ R + ++
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 436 KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKAS 495
L E+ + +Q LE + +E R L E + A S FK L+A
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM---EGAVKSKFKSTIAALEAK 1829
Query: 496 FAPMEDKLNQAHLEVQQLKASVKNYEG--------------MIDNYKSQVMKTRLEADEV 541
A +E+++ Q E Q S+K + M + YK Q K ++
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 542 AAQLERCDKENKILKDEMNKEIEAARRQFQSQL 574
QLE ++E ++ I A RR+ Q +L
Sbjct: 1890 KRQLEEAEEE--------SQRINANRRKLQREL 1914
Score = 76.6 bits (187), Expect = 6e-14
Identities = 102/472 (21%), Positives = 198/472 (41%), Gaps = 56/472 (11%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 155
++ R +K + + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 156 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDGAAAAKQVMALKDT 212
L N++ +K + + + + +EK + + + E E++ + + A
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA--- 1624
Query: 213 IGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQG 272
K K E + K+L LQ S + ++ L + Q +D +R +E
Sbjct: 1625 -AKKKLEGDL-----------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 273 ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA-SELSKSMESMRGHLQ 331
A + E + K K +E L ++Q + A A+ A + E + L
Sbjct: 1673 ASRDEIFATAKENEK-------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 332 AQLRSKEA---ENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR 388
+ L + A E RL +I LE + + +EA+ +++++ Q+ E L +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA----EQLSNELA 1781
Query: 389 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLE-SWRSRYNQVVKEKGDLELEIIVLN 447
++ A+K+E +QL Q +K+L L +E + +S++ + LE +I L
Sbjct: 1782 TERSTAQKNESARQQLERQ--NKEL--RSKLHEMEGAVKSKFKSTIAA---LEAKIAQLE 1834
Query: 448 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 507
++V ++Q + +++ L E L ++E+ER A +++ + +
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEIL---------LQVEDERKMAE--QYKEQAEKGN 1883
Query: 508 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEM 559
V+QLK ++ E + K + E DE E +E LK ++
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 97.4 bits (241), Expect = 3e-20
Identities = 112/524 (21%), Positives = 219/524 (41%), Gaps = 55/524 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 896 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 282
+K + ++ E + E Q+ LKR E D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 283 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 341
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 342 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 398
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 399 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQ 458
+ Q H Q V E LE ++ + K K LE E L + L +Q
Sbjct: 1195 QEMRQKHAQA------VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 459 TLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+E K + +L Q E + + ER +A + DK V +L+ V+
Sbjct: 1249 EVEHKKK--------KLEAQVQELQSKCSDGERARAE---LNDK-------VHKLQNEVE 1290
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ GM++ + + +K + +++QL+ ++L++E +++ + + L+
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK--------LR 1339
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDW 622
QL + + +L E + Q ER L +SD + +++D+
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Score = 89.7 bits (221), Expect = 7e-18
Identities = 99/496 (19%), Positives = 225/496 (45%), Gaps = 42/496 (8%)
Query: 136 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 191
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 192 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 249
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1450 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 250 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 309
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1508 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 310 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 369
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1559 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1611
Query: 370 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 425
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 426 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 485
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1727
Query: 486 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 545
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 546 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 605
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1837
Query: 606 IDLTAIISDLRSRVRD 621
T + ++++
Sbjct: 1838 QAATKSLKQKDKKLKE 1853
Score = 89.0 bits (219), Expect = 1e-17
Identities = 113/511 (22%), Positives = 227/511 (44%), Gaps = 49/511 (9%)
Query: 139 RKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQ-QEKECLMSKLVEAEM 197
++EE++ EL +T+ + K E + L++KH Q E++ L+ + ++AE
Sbjct: 850 QEEEMQAKEDELQKTKE---------RQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 198 DGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLRE 257
+ A A++ ++ + K E + ++ ++E Q+L E + + +L
Sbjct: 901 ELYAEAEE---MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA--ERKKMAQQMLDL 955
Query: 258 QHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDK------------DKEVEELLQE 305
+ E+ E Q+ L K AEA +K +L+ D ++ + +L
Sbjct: 956 EEQLEE-EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 306 IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 365
+ E+ +AK ++L ESM L+ +L+ +E L + LE + ++ +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 366 MEQLKELKQKGDRDKESLKKAI-RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 424
Q+ ELK + + +E L+ A+ R E A+K+ ++ + + ++++ L+S
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-----KIRELEGHISDLQEDLDS 1129
Query: 425 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 484
R+ N+ K+K DL E+ L + D ++ T ++++R R+ V L + E
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDE--- 1185
Query: 485 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 544
E +A M K QA E+ + K + +D K + K E ++A +
Sbjct: 1186 ---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE 1239
Query: 545 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQ----QLPDILKITEAKLAECQDQLQG 600
L R + K + K++EA ++ QS+ +D + +L D + + ++ L
Sbjct: 1240 L-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 601 YERKNIDLTAIISDLRSRVRDWQKGSHELTR 631
E K I L ++ L S+++D Q+ E TR
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Score = 85.1 bits (209), Expect = 2e-16
Identities = 119/548 (21%), Positives = 230/548 (41%), Gaps = 46/548 (8%)
Query: 95 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 154
D + N KKI L + L+ ++ ++ R A++ + EELE + EL +T
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT- 1158
Query: 155 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALK 210
++T + + R K E++ T+L KK L +E +++ E A A +Q+ K
Sbjct: 1159 LDSTATQQEL-RAKREQEVTVL-KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSER--- 266
L KQ + L + +L Q E + L ++E K D ER
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 267 --------LMEQQGALLKRLAEADSEKARL---LLLLQDKDKEVEELLQEIQCEKAQAKT 315
L + ++ L EA+ + +L + L + ++ +ELLQE E Q
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE---ETRQKLN 1333
Query: 316 ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK--NLERSGNQHK-AEVEAIMEQLKEL 372
S + +E R LQ QL + L I N++ S ++ K + + +E L+E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 373 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYV---AEALSTLESWRSRY 429
K++ ++ E+L + + +K E+ +L +L D + + + +S LE + ++
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 430 NQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLEN 489
+Q++ E+ ++ + DR +++T SL L + N
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKET-------KALSLARALEEALEAKEELERTN 1506
Query: 490 ERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD 549
+ LKA + + V +L+ S + E ++ K+Q+ + E R +
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 550 KENKILKDEMNKEIEA-------ARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYE 602
+ LK + ++++A RRQ Q QL + + + + A A + +L+G +
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG-D 1625
Query: 603 RKNIDLTA 610
K+++L A
Sbjct: 1626 LKDLELQA 1633
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/513 (21%), Positives = 194/513 (37%), Gaps = 58/513 (11%)
Query: 86 LSDLSTEDDDSGHCKMN--RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERK--- 140
L DL + D+ N + +K D L+ + S+ ++ + R E +
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 141 -EELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDG 199
LEE E E N +L+ +E + KD L++ K L +++ E +
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 200 AAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQ 258
++ A +D KL+ E M L Q E LQ + EE R L+ L E
Sbjct: 1549 EELEDELQATEDA--KLRLEVNM-----QALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 259 HCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE 318
+ + ER A K+ E D KD E LQ K + + +
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDL-----------KDLE----LQADSAIKGREEAIKQ 1646
Query: 319 LSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQK 375
L K M+ Q +L A + K E+ +A++ + E L + +++
Sbjct: 1647 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 376 GDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE 435
D +KE L + + + ++ +L ++A + + E +E+ R + ++
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 436 KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKAS 495
L E+ + +Q LE + +E R L E + A S FK L+A
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM---EGAVKSKFKSTIAALEAK 1822
Query: 496 FAPMEDKLNQAHLEVQQLKASVKNYEG--------------MIDNYKSQVMKTRLEADEV 541
A +E+++ Q E Q S+K + M + YK Q K ++
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 542 AAQLERCDKENKILKDEMNKEIEAARRQFQSQL 574
QLE ++E ++ I A RR+ Q +L
Sbjct: 1883 KRQLEEAEEE--------SQRINANRRKLQREL 1907
Score = 76.6 bits (187), Expect = 6e-14
Identities = 102/472 (21%), Positives = 198/472 (41%), Gaps = 56/472 (11%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 155
++ R +K + + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 156 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDGAAAAKQVMALKDT 212
L N++ +K + + + + +EK + + + E E++ + + A
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA--- 1617
Query: 213 IGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQG 272
K K E + K+L LQ S + ++ L + Q +D +R +E
Sbjct: 1618 -AKKKLEGDL-----------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 273 ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA-SELSKSMESMRGHLQ 331
A + E + K K +E L ++Q + A A+ A + E + L
Sbjct: 1666 ASRDEIFATAKENEK-------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 332 AQLRSKEA---ENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR 388
+ L + A E RL +I LE + + +EA+ +++++ Q+ E L +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA----EQLSNELA 1774
Query: 389 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLE-SWRSRYNQVVKEKGDLELEIIVLN 447
++ A+K+E +QL Q +K+L L +E + +S++ + LE +I L
Sbjct: 1775 TERSTAQKNESARQQLERQ--NKEL--RSKLHEMEGAVKSKFKSTIAA---LEAKIAQLE 1827
Query: 448 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 507
++V ++Q + +++ L E L ++E+ER A +++ + +
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEIL---------LQVEDERKMAE--QYKEQAEKGN 1876
Query: 508 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEM 559
V+QLK ++ E + K + E DE E +E LK ++
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 93.6 bits (231), Expect = 5e-19
Identities = 121/587 (20%), Positives = 262/587 (44%), Gaps = 67/587 (11%)
Query: 73 TPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMA 132
T P+ + V + ++ + D S H ++N Y ++ID L + L+ E + K Q
Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL 1866
Query: 133 KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKL 192
+ ++ EL + E T + ++++EE K+ ++EK+ L +L
Sbjct: 1867 ENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL 1926
Query: 193 VEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLR 252
+ Q+ L +IG C D+ + ELL ++ ++ L
Sbjct: 1927 M----------NQLAELNGSIGNY-------CQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 253 DLLREQHCKEDSERLMEQQGALLKRLAEADSEKA------RLLLLLQDKDKEVEELLQEI 306
+ ++Q KE ++ E + L+++ A E L LL++K +EV++L ++
Sbjct: 1970 E-EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKD- 2027
Query: 307 QCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSG----------N 356
C + Q K S L ++++++ + E L +++ +++ +
Sbjct: 2028 -CIRYQEK-ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 357 QHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVA 416
++E ++ +LK++ +KES+K ++ + E E+ E AE+ H++ + +
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLK---EKKNMQ 2142
Query: 417 EALSTLESWRSRYNQVVKE------KGDLELEIIV--LNDRVTDLVNQQQTLEEKMREDR 468
E L L + + + E K D E++ + L+ VT L +++ +++DR
Sbjct: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSM-SSLQDDR 2201
Query: 469 DSLVERLHRQTAEYS---AFKLENERLKA-SFAPMEDKLNQAHLEVQQLKASVKNYEGMI 524
D +++ + ++S K E RLK + + ++D+L Q + +++LK ++ E
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLE--- 2258
Query: 525 DNYKSQVMKTRLEADEVAAQLERCDK---ENKILKDEMNKEIEAARRQFQSQLADLQQLP 581
+ Q+ +++ + EV Q + CD ENK E+ ++E R + S +L +L
Sbjct: 2259 --HDKQIWESKAQT-EVQLQQKVCDTLQGENK----ELLSQLEETRHLYHSSQNELAKLE 2311
Query: 582 DILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHE 628
LK + +L + + L+ + + +L II + +++ K S+E
Sbjct: 2312 SELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-SKFSYE 2357
Score = 76.6 bits (187), Expect = 6e-14
Identities = 116/571 (20%), Positives = 238/571 (41%), Gaps = 80/571 (14%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTV 159
K + ++K+ A L+ + E+Q + +E K + ++ ++ + E T+
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTL 2627
Query: 160 -LRHNIERMKEEKD------FTILQKKHLQQEKECLMSKLVEAEMDGAAA---AKQVMAL 209
L H ++KEE+ F+ QK+ + E+E + + A+ G K++ L
Sbjct: 2628 GLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL 2687
Query: 210 KDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLRE------------ 257
G ++ E + + L R + QKL + N+ L ++
Sbjct: 2688 HHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSR 2747
Query: 258 QHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTAS 317
H E+ + L + A LK LA+ + LL +++D + E TA
Sbjct: 2748 DHANEELDELKRKYDASLKELAQLKEQG----LLNRERDALLSE-------------TAF 2790
Query: 318 ELSKSMESMRGHLQA---QLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQ 374
++ + E+ HL+ QL SK+ + L Q LE S NQ V++ + + L+
Sbjct: 2791 SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQ---LEDSYNQ----VQSFSKAMASLQN 2843
Query: 375 KGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVK 434
+ D L E+ KSEE ++ Q + V + S ++ ++++K
Sbjct: 2844 ERDHLWNEL--------EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLK 2895
Query: 435 EKGDLELEIIVLNDRVTDL-------------VNQQQTLEEKMREDRDSLVERLHRQTAE 481
E +L+ + + +N +T+L Q ++E++R++ S LH+ E
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME 2955
Query: 482 YSAFKLENERLKASF-APMEDKLNQ-AHLE--VQQLKASVKNYEGMIDNYKSQVMKTRLE 537
S++++ R+K + + DK Q +HL+ +++L++S + + Y+ Q
Sbjct: 2956 KSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSA 3015
Query: 538 ADEVAAQLERCDKENKILKDEMN---KEIEAARRQFQSQLADLQQLPDILKITEAKLAEC 594
+ + + L E ++L+ ++N KEI + Q ++ QL + +L +
Sbjct: 3016 SPDGSQNLV---YETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDT 3072
Query: 595 QDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
L+ ++ DL + L +V++ Q G
Sbjct: 3073 SQSLRENQQHYGDLLNHCAVLEKQVQELQAG 3103
Score = 71.6 bits (174), Expect = 2e-12
Identities = 127/602 (21%), Positives = 249/602 (41%), Gaps = 93/602 (15%)
Query: 98 HCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHEN 157
H ++N ++KI SL++ E +Q ++ ++ +E++E+ + L++ E EN
Sbjct: 2374 HEEINMKEQKIISLLSG-----KEEAIQVAIAELR----QQHDKEIKELENLLSQEEEEN 2424
Query: 158 TVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLK 217
VL +EE + + L + + + + ++ + + K + +L++ ++
Sbjct: 2425 IVL-------EEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV 2477
Query: 218 TEKQMTCTDINTLTRQKELLLQKLST----FEETNRTLR---DLLREQHCKEDSERLMEQ 270
+ Q ++ +K+ L+Q+ + +E R LR D L ++ K D+E L++
Sbjct: 2478 GDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE-LIQY 2536
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE-LSKSMESMRGH 329
+ L + + DS++ +LL + ++KE+E +++ + +++ A+E L +S +++
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
Query: 330 ---LQAQLRSKEAENSRLCMQIKNLERSGN------QHKAEVEAIMEQLKELKQKGDRDK 380
L ++ S + S+L Q+ L+ G Q K + E + R
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIA 2656
Query: 381 ESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLY----------------VAEALSTLES 424
E ++ + QKE A+K E ++L +L K L+ VAE L
Sbjct: 2657 ELEEELVCVQKEAAKKVGEIEDKLKKEL--KHLHHDAGIMRNETETAEERVAELARDLVE 2714
Query: 425 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE------------------ 466
+ V KE L +I ++ L N + E++ E
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
Query: 467 -----DRDSLVERLH---RQTAEYSAFKLE---------NERLKASFAPMEDKLNQAHLE 509
+RD+L+ T E S LE +E+L + +ED NQ
Sbjct: 2775 GLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ-S 2833
Query: 510 VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ AS++N + N + K+ AAQ E + LK M+ ++ R +
Sbjct: 2834 FSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS-LQNDRDR 2892
Query: 570 FQSQLADLQQLPDILKITE--AKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSH 627
+L +LQQ L+I + +L + QLQ Y+ K + +LR WQ H
Sbjct: 2893 LLKELKNLQQ--QYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELH 2950
Query: 628 EL 629
+L
Sbjct: 2951 QL 2952
Score = 70.5 bits (171), Expect = 5e-12
Identities = 113/553 (20%), Positives = 248/553 (44%), Gaps = 65/553 (11%)
Query: 83 VMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ-KGERQMAKRFLEERKE 141
V+ L D+ + D ++ + D+ + A ++K+ K + +++EE K
Sbjct: 61 VVELKDIIRQKD----VQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKA 116
Query: 142 ELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAA 201
+ V E + E + +H ++ E++ I + KH QEKE L+S L +A++ A
Sbjct: 117 QGGTVLP--TEPQSEEQLSKH--DKSSTEEEMEIEKIKHKLQEKEELISTL-QAQLTQAQ 171
Query: 202 AAK--QVMALKDTIGKLKTEKQMTCTDINTLTRQ----------KELLLQKLSTFEETNR 249
A + Q + +K + Q I+TL Q ++++ +K + FE R
Sbjct: 172 AEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVR 231
Query: 250 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 309
D L + + D E M+Q+ +L+R E E L + + V+ L QE+
Sbjct: 232 LHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEES------LVGRAQVVDLLQQELTAA 285
Query: 310 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLC--MQIKNLERSGNQH--KAEVEAI 365
+ + + S+ + ME+ L+ + ++ E+ L M+++ ER + H + E+ +
Sbjct: 286 EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHL 345
Query: 366 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 425
+EQ ++ Q + ES A+ QK +AE E+ + L +Q ++L S ++
Sbjct: 346 LEQFEQAGQ-AQAELESRYSALE-QKHKAEMEEKTSHILSLQKTGQELQ-----SACDAL 398
Query: 426 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 485
+ + ++++++K N++ Q LE+++++ + + L+R +
Sbjct: 399 KDQNSKLLQDK----------NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ---- 444
Query: 486 KLENERLKASFAPMEDKLNQAHLEV-QQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 544
+ AS D N+ V ++ AS++ ++N K ++ + +E +E+ A+
Sbjct: 445 ----QHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 545 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG-YER 603
E+ + +L + N+ EA R + + D+ K + + QD L+ + +
Sbjct: 501 NEKLSSQITLL-EAQNRTGEADREVSEISIVDIAN-----KRSSSAEESGQDVLENTFSQ 554
Query: 604 KNIDLTAIISDLR 616
K+ +L+ ++ +++
Sbjct: 555 KHKELSVLLLEMK 567
Score = 70.5 bits (171), Expect = 5e-12
Identities = 116/530 (21%), Positives = 213/530 (40%), Gaps = 103/530 (19%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L+ E K + + + + EL ++ EL + + T L +++E+ KE+K L+
Sbjct: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN--LE 2339
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
QQE + SK +++ L+ +++T + +++ +
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLET---------------DLQASRELTSRLHEEINMKEQKI 2384
Query: 238 LQKLSTFEETNRTLRDLLREQHCKE--DSERLMEQQGALLKRLAEADSEKARLLLLLQDK 295
+ LS EE + LR+QH KE + E L+ Q+ + E +++KA DK
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE-NIVLEEENKKA------VDK 2437
Query: 296 DKEVEELLQEIQCEKAQAKTASE-LSKSMESMRG---------------HLQAQLRSKE- 338
++ E L+ I+ E Q K + KSM S++ HL L +
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497
Query: 339 -----AENSRLCMQIKNLERSG---NQHKAEVEAIMEQLKE-----LKQKGDRDKESLKK 385
AEN++L +I+ L N A+++A + Q +E + K + K+ L+
Sbjct: 2498 IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557
Query: 386 AIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIV 445
++ KE K + E+L E+ E R +N + +EK DL EI
Sbjct: 2558 QLQQNKELENKYAKLEEKLK-----------ESEEANEDLRRSFNALQEEKQDLSKEIES 2606
Query: 446 LNDRVTDLVNQQQTLEEK-----MREDRDSLVERLHRQTAEYSA-----FKLENE----- 490
L ++ L Q L+E+ E +HR +A +S+ +LE E
Sbjct: 2607 LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQ 2666
Query: 491 -RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD 549
+EDKL + E++ L + + +V + + E+ +L
Sbjct: 2667 KEAAKKVGEIEDKLKK---ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVT 2723
Query: 550 KENKIL-----------------KDEMNKEIEAARRQFQSQLADLQQLPD 582
KENK L +D N+E++ +R++ + L +L QL +
Sbjct: 2724 KENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE 2773
Score = 69.3 bits (168), Expect = 1e-11
Identities = 115/564 (20%), Positives = 226/564 (40%), Gaps = 71/564 (12%)
Query: 70 LEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGER 129
LE +EKL S + L + ++ D+++ + K ++ +
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEA--------DREVSEISIVDIANKRSSSAEESGQ 545
Query: 130 QMAKRFLEERKEELEEVAHELAETEHENTVLRHNIE-RMKEEKDFTILQKKHLQQEKECL 188
+ + ++ +EL + E+ E + E L+ ++ + EE D +L +K ++Q
Sbjct: 546 DVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ----- 600
Query: 189 MSKLVEAEMDGAAAAKQVMALKDTIGKLK-----------TEKQMTCTDINTLTRQKELL 237
E +G A K + L+DT EK+ T+ + T ++ L
Sbjct: 601 ------MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
Query: 238 ----LQKLSTFEETNRTLRDLLREQHCKEDS-ERLMEQQGALLKRLAEADSEKARLLLL- 291
++ ST ++ +++L + C +D ERL Q L E + KA+ +
Sbjct: 655 NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILEL-----ELNFHKAQEIYEK 709
Query: 292 -LQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKN 350
L +K KE+ L Q I+ K A S ++ R L +Q++ + L Q+K
Sbjct: 710 NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMV-TELRAQVKQ 768
Query: 351 LE----RSGNQHKAEVEA-------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEE 399
LE + Q + + E+ + EQ+ L + K K Q E + +
Sbjct: 769 LEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEA---KSKDVKIEVLQNELDDVQLQ 825
Query: 400 YAEQ------LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDL 453
++EQ L QL +K+ V E + S+ ++ + ELEI ++ + +
Sbjct: 826 FSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEK 885
Query: 454 VNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQL 513
+TL++ + E + E T + E L ++++LN +
Sbjct: 886 KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAK 945
Query: 514 KASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ 573
K V+ DN S +K + A Q+ + + +++ D + KE E +R+ Q+
Sbjct: 946 KEQVEE-----DNEVSSGLKQNYDEMSPAGQISKEELQHEF--DLLKKENEQRKRKLQAA 998
Query: 574 LADLQQLPDILKITEAKLAECQDQ 597
L + ++L + E +LA +D+
Sbjct: 999 LINRKELLQRVSRLEEELANLKDE 1022
Score = 66.6 bits (161), Expect = 7e-11
Identities = 107/620 (17%), Positives = 240/620 (38%), Gaps = 113/620 (18%)
Query: 77 SEKLVSVMRLSDLSTEDDD---SGHCKMNRYDKKIDSLMNAVGCLKSEVKMQK---GERQ 130
SEK ++ ++ E +D + H ++ K+ D + + E+K + GE
Sbjct: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEES 1475
Query: 131 MAKRFLEERKEEL----EEVAHELAETEHENTVLRHNIERM--------------KEEKD 172
AK+ ++ + + +E E + E ++ R IER+ +EKD
Sbjct: 1476 RAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKD 1535
Query: 173 FTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTR 232
+ + LQ+E++ L++++ + ++ + + +LK + L +K+ +I +L
Sbjct: 1536 TVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595
Query: 233 QKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLL 292
K + +E + L ++ LL+ +E R+ ++
Sbjct: 1596 SK-------------------IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV 1636
Query: 293 QDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLE 352
+ +E +EL ++ +S E+ + + QL+ E E + +++
Sbjct: 1637 EAVRQEKQELYGKL--------------RSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 353 RSGNQHKAEVEAIMEQLK-ELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADK 411
+S Q E+E ++L+ E+ GD KE ++ + + E+ E +
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME-------- 1734
Query: 412 DLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSL 471
E+ ++ ++ EK L E+ L ++ V++Q LE + D +
Sbjct: 1735 ----------YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
Query: 472 V-----ERLHRQTAEYSAFKLENERLKASFAP--------------MEDKLNQAHLEVQQ 512
V + + +T E + + + P D++N ++ Q
Sbjct: 1785 VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844
Query: 513 LKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQS 572
LK + E K E + + +Q+ D E K+L++E+ K + +Q Q
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK-MNLLNQQIQE 1903
Query: 573 QLADLQQLPDILKITEAKLAE----------------CQDQLQGYERKNIDLTAIISDLR 616
+L+ + +L + + + L E CQD + + KN L + + +L+
Sbjct: 1904 ELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD-VTDAQIKNELLESEMKNLK 1962
Query: 617 SRVRDWQKGSHELTRAGARI 636
V + ++ +L + ++
Sbjct: 1963 KCVSELEEEKQQLVKEKTKV 1982
Score = 66.2 bits (160), Expect = 9e-11
Identities = 98/463 (21%), Positives = 197/463 (42%), Gaps = 74/463 (15%)
Query: 227 INTLTRQKELLLQKLSTFEETNRTLRDLLR-EQHCKEDSERLMEQQGALLKRLAEADSEK 285
++ L+ ++L +LS ++T++ +R L E H + D E Q + +RLA A+
Sbjct: 2 LSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLV 61
Query: 286 ARLLLLLQDKDKEVEELLQEIQCEK-------------AQAKTASELSKSMESMRGH--- 329
L +++ KD ++++ + +Q E+ A+AK S L+K +E M+
Sbjct: 62 VELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS-LNKYIEEMKAQGGT 120
Query: 330 -LQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR 388
L + +S+E Q+ ++S + + E+E I +L+E ++ + L +A
Sbjct: 121 VLPTEPQSEE--------QLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQA 172
Query: 389 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRY--NQVVKEKG--------- 437
Q ++ E + QL +K+ +++ + L ++ QVV+EK
Sbjct: 173 EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232
Query: 438 --DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER---LHRQTAEYSAFKLENERL 492
D L+++ D T++ + + L+ K+ E +SLV R + E +A + N+ L
Sbjct: 233 HEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQIL 292
Query: 493 KASFAPMEDK------------------LNQAHLEVQQLKASVKNYEGMIDNYKSQVMKT 534
ME + L + LEV + K S N + + + Q +
Sbjct: 293 SQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQA 352
Query: 535 RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAEC 594
E+ ++ ++++K +E I + ++ Q +LQ D LK +KL
Sbjct: 353 GQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQ----ELQSACDALKDQNSKL--- 405
Query: 595 QDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRAGARIP 637
LQ + + I L ++ Q+ S E+++ R+P
Sbjct: 406 ---LQDKNEQAVQSAQTIQQLEDQL---QQKSKEISQFLNRLP 442
Score = 63.2 bits (152), Expect = 7e-10
Identities = 108/531 (20%), Positives = 217/531 (40%), Gaps = 81/531 (15%)
Query: 143 LEEVAHELAETEHENTVLRHNI--ERMKEEKDFTILQK-----------KHLQQEKECLM 189
LEE + E H VL N+ + +D + LQ K ++ EK L
Sbjct: 1263 LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELE 1322
Query: 190 SKLVEAEMDGAAAAKQVMALKDTIGK-------LKT---EKQMTCTDINTLTRQKELLLQ 239
K+ + +++V L++ I K LKT E ++ + +L +
Sbjct: 1323 LKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIA 1382
Query: 240 KLSTFEETNRTLRDLLREQHCKED-----SERLMEQQGALLKRLAEADSEKARLLLL--- 291
L E L +L + KE+ S +L E++ AL K E ++ + L
Sbjct: 1383 GLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQ 1442
Query: 292 LQDKDKEVEELLQEIQCE----KAQAKTASELSKSMESMRGHLQAQLRS-KEA--EN--- 341
L+ + KE +E ++++Q E K + + E S++ + ++ LQA L S KEA EN
Sbjct: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSL 1502
Query: 342 -----------SRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ 390
RL + ++E + E + ++ +L L+++ D+ + +++
Sbjct: 1503 QEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLEN 1562
Query: 391 KERAEKSEEYAEQLHVQLADKDLYVAEALSTLES-------WRSRYNQVVKEKGDLELEI 443
+ + E L DK+ V E S S W+ ++ ++ K E EI
Sbjct: 1563 QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK-----EYEI 1617
Query: 444 IVLN-DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDK 502
++ + + V++ + Q + E +R+++ L +L A + + + + M++K
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677
Query: 503 LNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK- 561
+ + QQ + E D +++V D +E N +K+E+ +
Sbjct: 1678 MRKFAKSKQQ---KILELEEENDRLRAEVHPA---GDTAKECMETLLSSNASMKEELERV 1731
Query: 562 --EIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA 610
E E ++FQS +++ L + ++ + + Q++G K +L A
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLSE-------EVQDLKHQIEGNVSKQANLEA 1775
Score = 58.2 bits (139), Expect = 2e-08
Identities = 105/524 (20%), Positives = 217/524 (41%), Gaps = 67/524 (12%)
Query: 121 EVKMQKGERQMAKRFLEERKEELEE----------------VAHELA--ETEHENTVLRH 162
E+K K + + R E +KE++EE A +++ E +HE +L+
Sbjct: 927 EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
Query: 163 NIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDT----IGKLKT 218
E+ K + ++ +K L Q +S+L E + +K+ + L +T + + K
Sbjct: 987 ENEQRKRKLQAALINRKELLQR----VSRLEEELANLKDESKKEIPLSETERGEVEEDKE 1042
Query: 219 EKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLM---EQQGALL 275
K+ + + + ++ E+ L++ + +E QH ++D E + EQ AL+
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVEL--------QHIRKDLEEKLAAEEQFQALV 1094
Query: 276 KRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLR 335
K++ + +K + LLQ + E + ++Q++ A ++ E++
Sbjct: 1095 KQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT-G 1153
Query: 336 SKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQK---- 391
S E L +I LE+ Q + +++ + K + +K + L++ ++ QK
Sbjct: 1154 SSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213
Query: 392 ---ERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLND 448
E+ ++ + E + QL + V E++ + G LE +
Sbjct: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPG-LEEPLF---- 1268
Query: 449 RVTDLVNQQQTLEEKM-------REDRDSL-----VERLHRQTAEYSAFKLENERLKASF 496
+ T+ + Q LE + ED +L V ++ Q E A K+E E LK S
Sbjct: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELE-LKVSS 1327
Query: 497 APMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILK 556
E L + EV QL+ + I++ K+ + + A+ + +LE + L+
Sbjct: 1328 TTSE--LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE 1385
Query: 557 D--EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQL 598
E+ +++ ++ + D+ L L EA L + Q ++
Sbjct: 1386 HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI 1429
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 93.2 bits (230), Expect = 7e-19
Identities = 120/581 (20%), Positives = 254/581 (43%), Gaps = 77/581 (13%)
Query: 106 KKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTV-LRHNI 164
KK+ + L+ E++ ++ R ++ + ELEE++ L E +V + N
Sbjct: 1108 KKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167
Query: 165 ERMKE-EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMT 223
+R E +K L++ LQ E + A+ A +Q+ L+ KL+ EK
Sbjct: 1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEF 1226
Query: 224 CTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSER-----------LMEQQ 271
+++ +T E +++ + E+ +RTL D E K E+++R L +
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN 1286
Query: 272 GALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQ 331
G L ++L E ++ ++L +++E+L ++++ E+ +AK A L+ +++S R H
Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE-EEGKAKNA--LAHALQSAR-HDC 1342
Query: 332 AQLRSKEAENSRLCMQIKNLERSGNQH------KAEVEAIM--EQLKELKQKGDRDKESL 383
LR + E + +++ + N K E +AI E+L+E K+K + +
Sbjct: 1343 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1402
Query: 384 KKAIRAQKERAEKSEEYAEQLHVQLADKDLYV------AEALST--------LESWRSRY 429
++A+ A + E+ +L ++ D + V A AL L W+ +Y
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1462
Query: 430 NQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLEN 489
+ E + E L+ T+L + EE + H +T FK EN
Sbjct: 1463 EESQSELESSQKEARSLS---TELFKLKNAYEESLE----------HLET-----FKREN 1504
Query: 490 ERLKASFAPMEDKL--------------NQAHLEVQQLKASVKNYEGMIDNYKSQVMKTR 535
+ L+ + + ++L Q +E +L+++++ E +++ + ++++ +
Sbjct: 1505 KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQ 1564
Query: 536 LEADEVAAQLER----CDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKL 591
LE +++ A++ER D+E + K + +++ + ++ ++ + K E L
Sbjct: 1565 LEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDL 1624
Query: 592 AECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + QL R + + L+S ++D Q + RA
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1665
Score = 85.5 bits (210), Expect = 1e-16
Identities = 109/522 (20%), Positives = 231/522 (44%), Gaps = 72/522 (13%)
Query: 151 AETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSK------LVEAEMDGAAAAK 204
AETE E ++ R+KE + + ++K L+++ L+ + V+AE D A+
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 205 Q------------VMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLS----TFEETN 248
+ +K+ +L+ E++M LT +K L + S ++
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA----ELTAKKRKLEDECSELKKDIDDLE 960
Query: 249 RTLRDLLREQHCKEDS-ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQ 307
TL + +E+H E+ + L E+ L + +A+ EK L + ++ L ++Q
Sbjct: 961 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL-------QEAHQQALDDLQ 1013
Query: 308 CEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIME 367
E+ + + S+ +E L+ L ++ +LER+ + + +++ E
Sbjct: 1014 VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR-------MDLERAKRKLEGDLKLTQE 1066
Query: 368 QLKELKQKGDRDKESLKKA---IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 424
+ +L+ + +E LKK I Q + E + A QL +L + + E LE+
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126
Query: 425 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 484
R+ +V K + DL E+ +++R+ + +++ +M + R++ +++ R E +
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEAT- 1184
Query: 485 FKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAA 543
L++E A+ L + H + V +L + N + + + + + +LE D+V +
Sbjct: 1185 --LQHEATAAA-------LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
Query: 544 QLER-------CDKENKILKDEMNK---EIEAARR---QFQSQLADLQQLPDILKITEAK 590
+E+ +K ++ L+D+ N+ ++E A+R F +Q A LQ L +
Sbjct: 1236 NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGEL---ARQ 1292
Query: 591 LAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
L E + + R + T + DL+ ++ + K + L A
Sbjct: 1293 LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHA 1334
Score = 76.3 bits (186), Expect = 8e-14
Identities = 118/577 (20%), Positives = 236/577 (40%), Gaps = 86/577 (14%)
Query: 86 LSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEE 145
L DL E+D K+N K L V L+ ++ +K R +R + + +L+
Sbjct: 1009 LDDLQVEED-----KVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1063
Query: 146 VAHELAETEHENTVLRHNIERMK----------EEKDFTILQKKHLQQEKECLMSKLVEA 195
+ + E++ L +++ + E++ LQ + +E + + +L E
Sbjct: 1064 TQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE 1123
Query: 196 -EMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDL 254
E + A AK D +L+ + + Q E+ ++ + F++ R L +
Sbjct: 1124 LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1183
Query: 255 ----------LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQ 304
LR++H +E L EQ L + + + EK+ L L D +E++++
Sbjct: 1184 TLQHEATAAALRKKHADSVAE-LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242
Query: 305 EIQCEKAQAKT----ASELSKSMESMRGHLQ---AQLRSKEAENSRLCMQIKNLERSGNQ 357
+ ++T A+E +E + L Q + EN L Q++ E +Q
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQ 1302
Query: 358 ---HKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLY 414
K ME LK ++ + K +L A+++ + + E E+ A+
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1362
Query: 415 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 474
+++A S + WR++Y TD + + + LEE ++ L +R
Sbjct: 1363 LSKANSEVAQWRTKYE--------------------TDAIQRTEELEEAKKK----LAQR 1398
Query: 475 LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKT 534
L Q AE + E + A + +E ++ E++ L M+D +S
Sbjct: 1399 L--QDAEEAV-----EAVNAKCSSLEKTKHRLQNEIEDL---------MVDVERSNAAAA 1442
Query: 535 RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAEC 594
L D+ ++ E K +E E+E+++++ +S +L +L + + E
Sbjct: 1443 AL--DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE-------ES 1493
Query: 595 QDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTR 631
+ L+ ++R+N +L ISDL ++ + K HEL +
Sbjct: 1494 LEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEK 1530
Score = 72.8 bits (177), Expect = 9e-13
Identities = 126/606 (20%), Positives = 248/606 (40%), Gaps = 97/606 (16%)
Query: 62 KTKNPPHCLEITPPSSE-KLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKS 120
+TK ++ T E K RL D + E ++ + K + +K L N + L
Sbjct: 1374 RTKYETDAIQRTEELEEAKKKLAQRLQD-AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV 1432
Query: 121 EVK--------MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKD 172
+V+ + K +R K L E K++ EE EL ++ E L + ++K +
Sbjct: 1433 DVERSNAAAAALDKKQRNFDK-ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Query: 173 FTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTR 232
++ + ++E + L ++ + K V L+ +L+ EK L
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEK---------LEL 1542
Query: 233 QKELLLQKLSTFEETNRTLRDLLREQHCKEDSERL-------MEQQGALLKRLAEA---- 281
Q L + S E + LR L K + ER MEQ +R+ ++
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 282 -DSEKARLLLLLQDKDKEVEELLQ-EIQCEKAQ--AKTASELSKSMESMRGHLQAQLRSK 337
D+E +L+ K K +L + EIQ A A A + KS++S+ Q QL
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 338 EAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKS 397
N L I +ER N +AE+E +RA E+ E+S
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELE----------------------ELRAVVEQTERS 1700
Query: 398 EEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQ 457
+ AEQ ++ +++ ++ S+ ++ +K +E ++ L V + V +
Sbjct: 1701 RKLAEQELIETSER----------VQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 458 QTLEEKMRE---DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH------- 507
+ EEK ++ D + E L ++ + + + ++ + ++ +L++A
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG 1810
Query: 508 -LEVQQLKASVKNYEGMIDNYKSQ-------VMKTRLEADEVAAQLERCDKENKI----L 555
++Q+L+A V+ EG ++ + + + K+ E+ Q E DK+N + L
Sbjct: 1811 KKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEE-DKKNLLRLQDL 1869
Query: 556 KDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
D++ +++A +RQ ++ + +K + Q +L E + + ++ L
Sbjct: 1870 VDKLQLKVKAYKRQ-------AEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1922
Query: 616 RSRVRD 621
R++ RD
Sbjct: 1923 RAKSRD 1928
Score = 66.6 bits (161), Expect = 7e-11
Identities = 90/392 (22%), Positives = 165/392 (42%), Gaps = 46/392 (11%)
Query: 285 KARLLLLLQD-KDKEVEELLQEIQCEKAQAKTASELSKSMES------MRGHLQAQLRSK 337
KA LL LL++ +D+ + ++ +Q + E K +E ++ +++A + K
Sbjct: 768 KAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVK 827
Query: 338 EAENSRLCMQIKNLERSGNQHK--AEVEAIMEQLKELKQKGD--------------RDKE 381
+L +IK L +S K A ++ ++KE +K + ++K
Sbjct: 828 NWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKN 887
Query: 382 SLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLEL 441
L+ ++A+++ +EE +QL + V E LE ++ +K LE
Sbjct: 888 DLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 947
Query: 442 EIIVLNDRVTDL-------VNQQQTLEEKMR---EDRDSLVERLHRQTAEYSAFKLENER 491
E L + DL ++ E K++ E+ L E + + T E A + +++
Sbjct: 948 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1007
Query: 492 LKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM-----KTRLEADEVAAQLE 546
EDK+N +L+ V + EG ++ K M K +LE D Q
Sbjct: 1008 ALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1067
Query: 547 RCDKEN-KILKDEMNKEIEAARRQFQSQLADLQ----QLPDILKITEAKLAECQDQLQGY 601
D EN K+ +E K+ E Q S++ D Q QL LK +A++ E +++L+
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAE 1127
Query: 602 ERKNIDLTAIISDLRSRVRDWQKGSHELTRAG 633
+ + SDL R+ ++ S L AG
Sbjct: 1128 RTARAKVEKLRSDLS---RELEEISERLEEAG 1156
Score = 66.6 bits (161), Expect = 7e-11
Identities = 85/439 (19%), Positives = 198/439 (45%), Gaps = 35/439 (7%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
++ +++++K E Q A LEE + LE ++ + E ++ IER EKD + Q
Sbjct: 1531 VRKQLEVEKLELQSA---LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
K Q + ++AE + +V+ +K + E ++ + N + + +
Sbjct: 1588 AKRNHQRVVDSLQTSLDAE---TRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ 1644
Query: 238 LQKL-STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKD 296
++ L S ++T L D +R +++ ++E++ LL +A+ E+ R ++ ++
Sbjct: 1645 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL----QAELEELRAVVEQTERS 1700
Query: 297 KEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN 356
+++ E QE+ + + + S+ + + +++ L ++E + +N E
Sbjct: 1701 RKLAE--QELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAK 1758
Query: 357 QHKAEVEAIMEQLKELKQKG---DRDKESLKKAIRAQKERAEKSEEYA-EQLHVQLADKD 412
+ + + E+LK+ + +R K+++++ I+ + R +++E+ A + QL +
Sbjct: 1759 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1818
Query: 413 LYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLV 472
V E LE+ + R + VK E R+ +L Q + ++ + +D LV
Sbjct: 1819 ARVRELEGELEAEQKRNAESVKGMRKSER-------RIKELTYQTEEDKKNLLRLQD-LV 1870
Query: 473 ERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM 532
++L + Y K E++ N + ++++ + E D +SQV
Sbjct: 1871 DKLQLKVKAY----------KRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920
Query: 533 KTRLEADEVAAQLERCDKE 551
K R ++ ++ A+ + D+E
Sbjct: 1921 KLRAKSRDIGAKQKMHDEE 1939
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 92.8 bits (229), Expect = 9e-19
Identities = 133/606 (21%), Positives = 251/606 (41%), Gaps = 86/606 (14%)
Query: 88 DLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVA 147
++++ D + H + +Y + + L ++ + + + ERQ + + ELEE +
Sbjct: 507 EVASRDQEVEHVRQ-QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETS 565
Query: 148 HELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKL--VEAEMDGAAAA-- 203
ET H ++ + N E ++ K + + ++ +E L K+ ++ E++ A A+
Sbjct: 566 E---ETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAG 622
Query: 204 ---------KQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLST-------FEET 247
K+++ ++ + +L+ E+Q R+ E L L EE
Sbjct: 623 DTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQ 682
Query: 248 NRTLRDLLRE--QHCKEDSERLMEQQG-------------ALLKRLAEADSEKARLLLLL 292
N L+ L++ Q C+E S+ M + L+ E + E R +L L
Sbjct: 683 NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
Query: 293 QDKDKEVEEL--------------LQEIQCEKAQAKTASELSK----SMESMRGHLQAQL 334
+ + KE L LQ ++ EK Q + A S+ S+ + + L+A+L
Sbjct: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
Query: 335 RSKEAENSRLCMQIKNLERSGNQHKAEVEAIME---QLKELKQKGDRDKESLKKAIRAQK 391
+ +RL + + L R+ + + E + +L+E K+ DR + L K + +
Sbjct: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL---E 859
Query: 392 ERAEKSEEYAEQLHVQLAD----KDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN 447
+ E S++ +QL QL D VA+A + W S + L+ EI
Sbjct: 860 KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI---- 915
Query: 448 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 507
R+ + Q + R D++ L +RL E K + +E+K+++
Sbjct: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLE 975
Query: 508 LEVQQLKASVKNYEGMIDNYKSQV--MKTRLEADEVAAQLERCDKENKILKDEMNKEIE- 564
E+ + K +V+ ++ + QV ++T L + A Q CD KI + NK+++
Sbjct: 976 TELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECD---KISLERQNKDLKT 1032
Query: 565 --AARRQFQSQLADLQQ-------LPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
A+ FQ A L Q L + L+ E + Q + ERK +L+ I D
Sbjct: 1033 RLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDE 1092
Query: 616 RSRVRD 621
R V D
Sbjct: 1093 RQHVND 1098
Score = 64.3 bits (155), Expect = 3e-10
Identities = 86/403 (21%), Positives = 176/403 (43%), Gaps = 36/403 (8%)
Query: 136 LEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEA 195
LE K++LEE + E E + +E EE + + L QE++ L L E
Sbjct: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLAR---LGQEQQTLNRALEEE 826
Query: 196 EMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLL 255
KQ L+ +L+ +K++ ++ L ++ L+K+ E++ + L+ L
Sbjct: 827 -------GKQREVLRRGKAELEEQKRLLDRTVDRLNKE----LEKIG--EDSKQALQQLQ 873
Query: 256 RE-QHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAK 314
+ + KE + R + K A + + L LQD+ + + + LQ Q E+ A+
Sbjct: 874 AQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933
Query: 315 TASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQ 374
EL + ++G Q K +++ R Q+K LE ++ + E++ ++ L
Sbjct: 934 LDKELLA--QRLQGLEQEAENKKRSQDDR-ARQLKGLEEKVSRLETELDEEKNTVELLTD 990
Query: 375 KGDRDKESLKKA-IRAQKERAEKSEEYAEQLHVQLADKDLYV-----------AEALSTL 422
+ +R ++ + + +ER+ + + +++ ++ +KDL + +LS L
Sbjct: 991 RVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQL 1050
Query: 423 ESW----RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQ 478
ES + R +EK L+ L +V +L Q + + + + +D L R+
Sbjct: 1051 ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKAL 1110
Query: 479 TAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYE 521
+ + E ERL + ++ + H +QL+A +K+ E
Sbjct: 1111 KRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1153
Score = 61.2 bits (147), Expect = 3e-09
Identities = 69/316 (21%), Positives = 152/316 (48%), Gaps = 21/316 (6%)
Query: 125 QKGERQMA--KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQ 182
+K R++A +R ++ E E+ + L+ + E LR ++ + E+D L K+ L
Sbjct: 881 EKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLA 940
Query: 183 QEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLS 242
Q + L + + A+Q+ L++ + +L+TE + NT+ ELL +++
Sbjct: 941 QRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELD---EEKNTV----ELLTDRVN 993
Query: 243 TFEETNRTLR-DLLREQHCKEDSE----RLMEQQGALLKRLAEAD--SEKARLLLLLQDK 295
+ LR +L++E+ ++D E L Q L RLA ++ + + L L+ +
Sbjct: 994 RGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQ 1053
Query: 296 DKEVEELLQEIQCEKAQAK-TASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERS 354
++ ++E LQ + EK + T +L + ++ + ++ + + + +L +++K L+R
Sbjct: 1054 NQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQ 1113
Query: 355 GNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLY 414
++ + E+ E+L L++K R+ E + + R + E+ + + + A +
Sbjct: 1114 VDEAEEEI----ERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169
Query: 415 VAEALSTLESWRSRYN 430
E LS+ E + S Y+
Sbjct: 1170 KNEGLSSDEEFDSVYD 1185
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 92.4 bits (228), Expect = 1e-18
Identities = 131/551 (23%), Positives = 239/551 (43%), Gaps = 86/551 (15%)
Query: 117 CLKSEVKMQKGERQMAKRFL-------EERKEELEEVAHELAETEHENTVLRHNIERMKE 169
C + +K +G+R+ + L EER +EL+ + ++ + E +TVL ++ +
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 170 EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT 229
E Q + LQ++KE L L + +++M K+ I L+ ++
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRD-------QELMLQKERIQVLEDQR--------- 1674
Query: 230 LTRQKELLLQKLSTFEETNRTLRDLLREQHCKED--SERLMEQQGALLKRLAEADSEKAR 287
TRQ ++L + L E+ +LR+ RE + ER E +G + + K
Sbjct: 1675 -TRQTKILEEDL---EQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK-- 1728
Query: 288 LLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQ 347
L+L+DK+KEVE C++ EL +E LQ L K E S L
Sbjct: 1729 --LILRDKEKEVE-------CQQEHIHELQELKDQLEQ---QLQG-LHRKVGETSLLL-- 1773
Query: 348 IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAI-RAQKERAEKSEEY--AEQL 404
+Q + E+ + +QL+E +++G+ ++SL+ + AQ+ A++ +E +Q
Sbjct: 1774 --------SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 405 HVQLADKDLYVAEALSTLESWRSRYNQVVKEKGD-----------LELEIIVLNDRVTDL 453
Q ++ V E L+ + + +KE+ LE E+ V RV L
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
Query: 454 VNQQQTLEEKMREDRDSLVERLHRQTAEYS-AFKLENERLKASFAPMEDKLNQAHLEVQQ 512
L + RE +L+ L +Q AE + ++E L+ S+ + L + E++
Sbjct: 1886 EEVLGDLRAESREQEKALL-ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEA 1944
Query: 513 LKASVKNYEGMIDNYKSQVMKTRLEADEVA---AQLERCDKENKILKD-EMNKEIEAARR 568
L+A E ++ + + R EA + A A KE +L+ E+++ +EA+
Sbjct: 1945 LRA-----ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 569 QFQSQL----ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQK 624
Q+ L A +QL + L+I E E QDQ Y+ L ++ +R Q+
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQE---GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 625 GSHELTRAGAR 635
L ++ A+
Sbjct: 2057 REQLLEKSLAQ 2067
Score = 82.8 bits (203), Expect = 9e-16
Identities = 125/554 (22%), Positives = 243/554 (43%), Gaps = 65/554 (11%)
Query: 100 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTV 159
++ ++ + S M A ++ +++ E + + L E+ LE + E E
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQA 680
Query: 160 LRHNIERMKEEKDFTILQKKH-----------LQQEKECLMSKLVEAEMDGAAAAKQVMA 208
+I+ KEE + + +H L QE + L A + A ++ A
Sbjct: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA 740
Query: 209 LKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTL----------------- 251
L+ + ++ ++Q + L+ KELL L ++ N +
Sbjct: 741 LEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA 800
Query: 252 RDLLR-EQHCKE---DSERLMEQQ--GALLKRLAEADSE-KARLLLLLQDKDKEVEELLQ 304
+++++ E C + D+ER +Q A ++LA+A+ E K L +KEV +L +
Sbjct: 801 KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE 860
Query: 305 EIQCEKAQAKTASELSKSMESM-RGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVE 363
+ EK ++ EL+K++ES+ R ++ ++R KE + M+ +R + +AE
Sbjct: 861 --KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE---MEAIQAQREEERTQAESA 915
Query: 364 AIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLE 423
QL+ K++ L+ ++ QKE A+ S++ E+L + + L E L+
Sbjct: 916 LCQMQLETEKER----VSLLETLLQTQKELADASQQ-LERLRQDMKVQKLKEQETTGILQ 970
Query: 424 SWRSRYNQVVKE-----KGDL----ELEIIVLNDRVTDLVNQQQTLEEKM--REDRDSLV 472
+ + +KE + DL E +L D++ DL Q + L+ ++ ++D LV
Sbjct: 971 TQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM-DLQKQVEDLKSQLVAQDDSQRLV 1029
Query: 473 ER----LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+ R+T EY+ + E ER KAS + Q L +Q+ S++ E + +
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEAD-SIRQQE--LSALR 1086
Query: 529 SQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITE 588
+ + + E E++AQ+E +E K + + + + ++ QQL L E
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146
Query: 589 AKLAECQDQLQGYE 602
AK A+ Q +L+ E
Sbjct: 1147 AKAAQLQLRLRSTE 1160
Score = 79.3 bits (194), Expect = 1e-14
Identities = 114/530 (21%), Positives = 233/530 (43%), Gaps = 64/530 (12%)
Query: 109 DSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLR---HNIE 165
D+L L+ EV ER++ ++ EE +++LE + E N L+ + +
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQ 504
Query: 166 RMKEEKDFTILQKKHLQ-QEKECLMSKLVEAEMDGAAAAKQVMALKDTI------GKLKT 218
KEE+ ++ HL +E+E L L+ E + + +++ L++ + G+L
Sbjct: 505 GQKEEQQ----EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLR 560
Query: 219 EKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKED--SERLMEQQGALLK 276
++Q T++ + E + +LS+ E T +T LR K +E L + L +
Sbjct: 561 QEQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQ 617
Query: 277 RLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRS 336
+L + + E + + + E+ +Q + A+A+ E ++ HL+AQL+
Sbjct: 618 QLLQLEEENQSVC----SRMEAAEQARNALQVDLAEAEKRRE---ALWEKNTHLEAQLQK 670
Query: 337 KEAENSRLCMQIKN-------LERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRA 389
E + L +++ +++ ++ + + EA QL++L Q+ R +E L +A+
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV-- 728
Query: 390 QKERAEKSEEYAEQLHVQLADKDLY-VAEALSTLESWR----------SRYNQVVK-EKG 437
Q++ A E+ A ++ +Q ++D +AE L L S + + N V++ KG
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
LE++I + + + + L+ ++ +R + R A + E E A
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQ--ERDAAARQLAQAEQEGKTA--- 843
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
+E + EV QL+ + +E ++ ++ K + +LE KE + +
Sbjct: 844 -LEQQKAAHEKEVNQLR---EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME 899
Query: 558 EMNKEIEAARRQFQSQLADLQ--------QLPDILKITEAKLAECQDQLQ 599
+ + E R Q +S L +Q L + L T+ +LA+ QL+
Sbjct: 900 AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
Score = 73.2 bits (178), Expect = 7e-13
Identities = 117/585 (20%), Positives = 239/585 (40%), Gaps = 87/585 (14%)
Query: 94 DDSGHCKMNRYDKKIDSL--MNAVGCLKSEVKMQKGERQMAKR---------------FL 136
D S + R D K+ L G L+++++ + E + A R L
Sbjct: 943 DASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002
Query: 137 EER---KEELEEVAHELAETEHENTVLRHNI-ERMKEEKDFTILQKKHLQQEKECLMSKL 192
+++ ++++E++ +L + ++ + E+++E +++ +QK+ L++EK L L
Sbjct: 1003 QDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKE-LEREKASLTLSL 1061
Query: 193 VEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLR 252
+E E + + + L+ + Q + L+ Q ELL Q++ E
Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Query: 253 DLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQC---E 309
L E+ ++ + EQQ L L +++ A+L L L+ + ++E L E Q
Sbjct: 1122 AQLLEEL---EASHITEQQ--LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA 1176
Query: 310 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA--------- 360
+AQA+ AS S +++ +++ +S + LE N ++
Sbjct: 1177 QAQAQLASLYSALQQALGSVCESRPELSGGGDS--APSVWGLEPDQNGARSLFKRGPLLT 1234
Query: 361 --EVEAIMEQLKELKQ---KGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYV 415
EA+ L +L Q K + ++ L+ ++ +ER +E Q+H +L D +
Sbjct: 1235 ALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
Query: 416 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQ------QQTLEEKMREDRD 469
++ W + N + E +L + L R+ Q ++ L + +E+
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLT 1354
Query: 470 SLVERLHRQTAE------------------YSAFKLENERLKASFAPMEDKLNQAHLEVQ 511
+ VE L E SA KL+NE +++ + Q L+V
Sbjct: 1355 AQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVA 1414
Query: 512 QLKASVKNY----------EGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK 561
Q KA +N E ++ + Q+ + + + A LE + K + N+
Sbjct: 1415 QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK----KRNQ 1470
Query: 562 EIEAARRQFQSQ---LADLQQLPDILKITEAKLAECQDQLQGYER 603
E++ + Q Q + L+ LP ++ E KL ++Q++ E+
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK 1515
Score = 68.9 bits (167), Expect = 1e-11
Identities = 100/446 (22%), Positives = 187/446 (41%), Gaps = 41/446 (9%)
Query: 205 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 264
QV L++ + + EK T++ L RQ ++ S +E +L L E H E
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELH--ETM 1322
Query: 265 ERLMEQ-QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSM 323
L + + A L+R+ EA E+ L ++ +VE L + +AQA A L + +
Sbjct: 1323 ASLQSRLRRAELQRM-EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 324 ESMRGHLQAQLRSKEAENSR-----------------LCMQIKNLERSGNQHKAEVEAIM 366
+ R L+ + E+E R L + L ++ + + EVE +
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 367 EQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWR 426
Q++EL+++ + K +L+ K+R ++ + EQ +Q +K V E L R
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ--IQELEKCRSVLEHLPMAVQER 1499
Query: 427 SRYNQVVKE-----KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAE 481
+ V +E + D E + VL ++ +L + Q +E + + +D L ++L T E
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD-LKKQL--VTLE 1556
Query: 482 YSAFKLENERLKAS-----FAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRL 536
A +LE K +E + + + L ++ + SQ+
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
Query: 537 EADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 596
+ +A +L+ D+E K ++IE +RQ + DL++ L + + ++ +D
Sbjct: 1617 HSTVLARELQERDQEVK----SQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672
Query: 597 QLQGYER-KNIDLTAIISDLRSRVRD 621
Q + DL I LR R R+
Sbjct: 1673 QRTRQTKILEEDLEQIKLSLRERGRE 1698
Score = 66.2 bits (160), Expect = 9e-11
Identities = 130/621 (20%), Positives = 240/621 (38%), Gaps = 121/621 (19%)
Query: 77 SEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFL 136
S++ ++ L E + G K ++D A+ E++ + E+Q A+
Sbjct: 1774 SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG-Q 1832
Query: 137 EERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAE 196
EER +E + E H RH LQ KE ++ +E E
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHG----------------ELQDHKE--QARRLEEE 1874
Query: 197 MDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLR 256
+ A ++V AL++ +G L+ E +R++E L L
Sbjct: 1875 L--AVEGRRVQALEEVLGDLRAE-----------SREQEKAL---------------LAL 1906
Query: 257 EQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA 316
+Q C E ++ + AL +A + +L+++D+E+E L E Q + Q + A
Sbjct: 1907 QQQCAEQAQEHEVETRALQDSWLQAQA-------VLKERDQELEALRAESQSSRHQEEAA 1959
Query: 317 SELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELK--- 373
+++++ G A L+ KE ++LE S +A ++A ++L+
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 374 --QKG---DRDKESLKKAIRAQKERAEKSEEYA-EQLHVQLADKDLYVAEALSTLESWRS 427
Q+G D+D + + Q+ A++ EE +Q QL +K L + +
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL-AQRVQENMIQEKQ 2078
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA---EYSA 484
Q +E+ L V ++T +Q+ LE + + R++L H E +
Sbjct: 2079 NLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS 2138
Query: 485 FKLEN---------ERLKASFAPME-------DKLNQAHLEVQQLKASVKNYEGMI---- 524
KL++ ERL+A+ E +K L + Q KASV + + +
Sbjct: 2139 LKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQ 2198
Query: 525 -----DNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKE------------IEA-- 565
+ + Q ++ LE A + ER E+ +EA
Sbjct: 2199 ASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEP 2258
Query: 566 -----ARRQFQSQLADLQQLPDILKITEAKL----AECQDQLQGYERKNIDLTAIISDLR 616
++ ++ +L LQQ L+I ++L + + L+ ER+ L R
Sbjct: 2259 SPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK------R 2312
Query: 617 SRVRDWQKGSHELTRAGARIP 637
+R Q GS E+++A A P
Sbjct: 2313 EAMRAAQAGSLEISKATASSP 2333
Score = 61.6 bits (148), Expect = 2e-09
Identities = 103/493 (20%), Positives = 205/493 (41%), Gaps = 57/493 (11%)
Query: 139 RKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMD 198
+ +ELE+ AHE ++ + ++K + D L+K LQ L + L +++
Sbjct: 252 KTQELEKEAHERSQ----------ELIQLKSQGD---LEKAELQDRVTELSALLTQSQKQ 298
Query: 199 GAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLRE- 257
K + AL++T+ L+T +L+R + +KLS + + ++ E
Sbjct: 299 NEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQE--EKLSLQQVIKDITQVMVEEG 356
Query: 258 QHCKEDS--ERLMEQQGALLKRLAEADSEKARLLL--LLQDKDKEVEELLQEIQCEKAQA 313
+ + S E +E ++ + D++KA L+ +L + + V++L Q++ +
Sbjct: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
Query: 314 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELK 373
+ E L+ +L+ E L Q +L+ EV+++
Sbjct: 417 NLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ-------GEVDSL-------- 461
Query: 374 QKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV 433
+++E L+KA +++ E E+ A +L + L A E + + V
Sbjct: 462 ---SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAV 518
Query: 434 KEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLK 493
+E+ L+ ++ L + ++ +++ TL E + E E L ++ E +A E+
Sbjct: 519 RERERLQEMLMGLEAKQSESLSELITLREAL-ESSHLEGELLRQEQTEVTAALARAEQ-- 575
Query: 494 ASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAA--QLERCDKE 551
S A + N EV L+A+ K + L D+V QL + ++E
Sbjct: 576 -SIAELSSSENTLKTEVADLRAAA---------VKLSALNEALALDKVGLNQQLLQLEEE 625
Query: 552 NKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAI 611
N+ + M + E AR Q LA+ ++ + L K + QLQ E +L A
Sbjct: 626 NQSVCSRM-EAAEQARNALQVDLAEAEKRREALW---EKNTHLEAQLQKAEEAGAELQAD 681
Query: 612 ISDLRSRVRDWQK 624
+ D++ + QK
Sbjct: 682 LRDIQEEKEEIQK 694
Score = 49.3 bits (116), Expect = 1e-05
Identities = 122/617 (19%), Positives = 241/617 (39%), Gaps = 62/617 (10%)
Query: 61 VKTKNPPHCLEITPPSSEKLV---SVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGC 117
++T++P L P S +LV V+ L E+ + K+ + V
Sbjct: 1 METRSPG--LNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRK 58
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
L+++V + Q ++ LE + + + E + ++R E+ + E +
Sbjct: 59 LQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNT 118
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTE---KQMTCTDINTL 230
+ L EK +++K + +++ A+ + K++ +++ E + L
Sbjct: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Query: 231 TRQKELLLQKLSTFEETNRTLRDL--LREQHCKEDSERL-------MEQQGALLKRLAEA 281
+ +E++ + E + T RDL L+ +H + L + Q
Sbjct: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
Query: 282 DSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKS-MESMRGHLQAQLRSKEAE 340
D + LLLL K +E+E+ E E Q K+ +L K+ ++ L A L + +
Sbjct: 239 DGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQ 298
Query: 341 NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR------------ 388
N IK L + + +ME L + +K SL++ I+
Sbjct: 299 NEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDN 358
Query: 389 -AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN 447
AQ E S E + Q +D +AL+ + S +R Q V+ DL ++
Sbjct: 359 IAQGSGHENSLELDSSIFSQFDYQD--ADKALTLVRSVLTRRRQAVQ---DLRQQLAGCQ 413
Query: 448 DRVTDLVNQQQTLEE----------KMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ V L Q EE K+ +RD+L + E + E E L+ +
Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
+ +L E +L+ N E + +Q K +E +L +E + L+
Sbjct: 474 ELRQQLEVLEQEAWRLRR--VNVELQLQGDSAQGQK-----EEQQEELHLAVRERERLQ- 525
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQ----LQGYERKNIDLTAIIS 613
EM +EA + + S+L L++ + + L + Q + L E+ +L++ +
Sbjct: 526 EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 614 DLRSRVRDWQKGSHELT 630
L++ V D + + +L+
Sbjct: 586 TLKTEVADLRAAAVKLS 602
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 92.4 bits (228), Expect = 1e-18
Identities = 142/608 (23%), Positives = 263/608 (43%), Gaps = 113/608 (18%)
Query: 64 KNPPHCLEITPPSSE--KLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSE 121
K P LE S+E K++ V+ + ++ G + Y+K I L
Sbjct: 105 KTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGE---DVYEKPISELD--------- 152
Query: 122 VKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHL 181
++++ +++ +R LE+ L E H E EN +H + M + DFT L L
Sbjct: 153 -RLEEKQKETYRRMLEQLL--LAEKCHRRTVYELENEKHKHT-DYMNKSDDFTNL----L 204
Query: 182 QQEKECLMSKLVEAEMDGAAA-----AKQVMALKDTIGKLKT-------EKQMTCTDINT 229
+QE+E L KL+E E A AK++ L+D + KLK+ E+QM +
Sbjct: 205 EQERERL-KKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGL 263
Query: 230 LTRQKELLLQKLSTFEETNRTLRDLLREQHCK---------EDSERLMEQQGALLKRLAE 280
+++ + L QKL EE + + +E K + R ++ + +LA
Sbjct: 264 QSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLAN 323
Query: 281 ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAE 340
+S +L L L + +EEL +T L K+ E ++ L+ ++ E
Sbjct: 324 QESHNRQLRLKLVGLTQRIEEL----------EETNKNLQKAEEELQ-ELRDKIAKGECG 372
Query: 341 NSRLCMQIKNLERSGNQHKAEVEAIME---QLKELKQKGDRDKESLKKAIRAQKERAEK- 396
NS L +++NL + + + + E I + Q +EL++K +++E K +R + E+ +K
Sbjct: 373 NSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKL-QEEEHHSKELRLEVEKLQKR 431
Query: 397 -------------SEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEI 443
S+ QLH+ L + + L+ LE +SR ++ + LE
Sbjct: 432 MSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAE 491
Query: 444 IVLNDRVTD-------LVNQQQTLEEKMREDR---DSLVERLHRQTAEYS--AFKL--EN 489
+ L D +T LV++++ + EK++++ D L + + + KL E+
Sbjct: 492 LSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEES 551
Query: 490 ERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQV--MKTRLEA-DEVAAQLE 546
++L + ME+K+ E +L +K+ E V +K RL+ +EV ++
Sbjct: 552 KKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREIT 611
Query: 547 R----------CDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 596
R C ++NKI E+ EIE +++ Q L++ E L + +D
Sbjct: 612 RGRSRKGSELTCPEDNKI--KELTLEIERLKKRLQQ-----------LEVVEGDLMKTED 658
Query: 597 QLQGYERK 604
+ E+K
Sbjct: 659 EYDQLEQK 666
Score = 76.6 bits (187), Expect = 6e-14
Identities = 83/367 (22%), Positives = 174/367 (47%), Gaps = 48/367 (13%)
Query: 117 CLKSEVKMQKGERQMAKRFLE-----ERKEELEEVAHELAETEHENTVLRHNIERMKEEK 171
C + K+Q+ E + LE +R ELE++ ++++ E T L N+E+ EK
Sbjct: 404 CRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEK---EK 460
Query: 172 DFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLT 231
+ T K L E E + S++ E E + K ++LKD + KLK+ M L
Sbjct: 461 NLT----KDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVM-------LV 509
Query: 232 RQKELLLQKLSTFEETNRTLRDLLREQHCK--EDSERLMEQQGALLKRLAEADSEKARLL 289
+++ +++K+ E L + + K + +E+L+E+ LLK +E + + L
Sbjct: 510 DERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLT 569
Query: 290 LLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQ-------LRSKEAENS 342
+E +EL+ ++ K++ + +SELS S++ ++ L R + + S
Sbjct: 570 -------RERDELIGKL---KSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGS 619
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELK------QKGDRDKESLKKAIRAQKERAEK 396
L N + + E+E + ++L++L+ K + + + L++ R ++++A
Sbjct: 620 ELTCPEDNKIK---ELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANF 676
Query: 397 SEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVN 455
+ E++ Q+A +K + E +S R R+ + DL+ E+ L +++ +L+N
Sbjct: 677 LSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMN 736
Query: 456 QQQTLEE 462
++ L +
Sbjct: 737 KEDQLSQ 743
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 91.7 bits (226), Expect = 2e-18
Identities = 125/548 (22%), Positives = 236/548 (43%), Gaps = 96/548 (17%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
LKS++ + +R K+ +EE EE + ++ +E+ L +E++ + D +
Sbjct: 390 LKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDAS 449
Query: 178 KKHLQQE-KECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKEL 236
+K E EC S++++ E + + + L+D L+ E + C ++ Q
Sbjct: 450 RKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLE-ESGLKCGELEKENHQLSK 508
Query: 237 LLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKD 296
++KL T L RE+ +D E L E+ + E + ++ + L DK
Sbjct: 509 KIEKLQT---------QLEREKQSNQDLETLSEEL------IREKEQLQSDMETLKADKA 553
Query: 297 KEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQ----AQLRSKEAENSRLCMQIKNLE 352
+++++L QE L+++M S+R Q A+++ E EN L +
Sbjct: 554 RQIKDLEQE----------KDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN 603
Query: 353 RSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA---------EKSEEYAEQ 403
+Q + E + L++ K+KG+R ++ ++ R Q+E E + E E
Sbjct: 604 GKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEA 663
Query: 404 LH-----VQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVL----------ND 448
L +QL ++ L ++L TL++ + + ++ L+ E + L +
Sbjct: 664 LEHESQGLQLENRTL--RKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTST 721
Query: 449 RVTDLVNQQQTLE---EKMREDRD---SLVERLHRQTAEYSAFKLENERLKASFAPMEDK 502
++ + + Q LE E++R++ D +L ++ R Y + EN RL+ S K
Sbjct: 722 KLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHK 781
Query: 503 LNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVA-AQLERCDKENKIL------ 555
E+ +L+A + Q ++ LEA +A AQLE +K+ K L
Sbjct: 782 TQTLESELGELEA------------ERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ 829
Query: 556 --KDEMNKEIEAARRQFQSQLAD---------LQQLPDILKITEAKLAECQD---QLQGY 601
KD+ E EA R Q +L D L + + + +LA C+D +L+
Sbjct: 830 LEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKEL 889
Query: 602 ERKNIDLT 609
E+ N DLT
Sbjct: 890 EKDNRDLT 897
Score = 74.3 bits (181), Expect = 3e-13
Identities = 119/554 (21%), Positives = 230/554 (41%), Gaps = 74/554 (13%)
Query: 109 DSLMNAVGCLKSEVKMQKG-ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERM 167
DS + L SE K E K L ++ELE+ +L +T HE L ++++
Sbjct: 235 DSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKV 294
Query: 168 KEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA-AKQVMALKDTIGKLKTEKQMTCTD 226
K+E ++Q + ++ E+D A +V L+ + + K + D
Sbjct: 295 KQE---------NIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLH----D 341
Query: 227 INTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKA 286
++ + E L + ET L + L + D +E++ LK K
Sbjct: 342 VDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLK-------SKL 394
Query: 287 RLLLLLQDKDKE-VEELLQE-IQCEKAQAKTASE---LSKSMESMRGHLQAQLRSKEAE- 340
L L +D DK+ +EELL+E + E AQ ++ +E L +E + + S+++
Sbjct: 395 HDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFV 454
Query: 341 ---NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKG------DRDKESLKKAI---R 388
N +I LE+ ++ ++ + + L++ G +++ L K I +
Sbjct: 455 FELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQ 514
Query: 389 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLND 448
Q ER ++S + E L +L + + + TL++ ++R + DLE E LN
Sbjct: 515 TQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIK------DLEQEKDHLNR 568
Query: 449 RVTDLVNQQQTLEEKMREDRDSLVERLHRQTAE----YSAFKLENERLKASFAPMEDKLN 504
+ L + Q E +D + + LH+ E S + E +L ++K
Sbjct: 569 AMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGE 628
Query: 505 QAHL---EVQQLKASVKNYEGMIDNYKSQVMKTR-LEADEVAAQLERCDKENKILKDEMN 560
+A E+Q+L+ + + ++ K LE + QLE N+ L+ ++
Sbjct: 629 RAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLE-----NRTLRKSLD 683
Query: 561 ---------KEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYE------RKN 605
+ +E +Q ++ +L++L + ++ T KLA+ + + Q E RKN
Sbjct: 684 TLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKN 743
Query: 606 IDLTAIISDLRSRV 619
+DL + R+
Sbjct: 744 VDLLKALGKKSERL 757
Score = 63.5 bits (153), Expect = 6e-10
Identities = 116/551 (21%), Positives = 219/551 (39%), Gaps = 113/551 (20%)
Query: 103 RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRH 162
R + ++S + L+SE+ + ERQ +R LE L +L E + L
Sbjct: 770 RLQQSLESSSHKTQTLESELGELEAERQALRRDLEA----LRLANAQLEGAEKDRKALEQ 825
Query: 163 NIERMKEEKDFTILQKKHLQQEKECL-------MSKLVEAEMDGAAAAKQVMALKDTIGK 215
+ +++++K + K L Q+ E +KL E + A K++ +D GK
Sbjct: 826 EVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGK 885
Query: 216 LKT--------EKQMTCTDINTLTRQKELLLQKLST-------------FEETNRTLRDL 254
LK KQ+T T +++L+L+KL + E+ L
Sbjct: 886 LKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELL 945
Query: 255 LREQHCKEDSE-RLME--QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKA 311
L+E D++ +++E + AL LA + + L +++K +L E+Q K
Sbjct: 946 LQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKK 1005
Query: 312 QAKTASE-------LSKSMESMRGHLQAQLRSKEA------ENSRLCMQIKN----LERS 354
+ +T + L S + G A + KEA E + +++K+ LER+
Sbjct: 1006 ECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERN 1065
Query: 355 GNQHKAEVEAIMEQLKELK----------------------------------QKGDRDK 380
+AE + + EQL+ L+ Q +
Sbjct: 1066 NAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTL 1125
Query: 381 ESLKKAIRAQ----------KERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRS-RY 429
S A+ AQ KE +S + ++ + L E L TL +S Y
Sbjct: 1126 SSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEY 1185
Query: 430 NQVVKEKG-------DLELEIIVLNDRVTDLVNQQQTLEEK---MREDRDSLVERLHRQT 479
++++ +LELE L +R D++ ++ LEE+ + +R++L +Q
Sbjct: 1186 EALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREAL-----QQE 1240
Query: 480 AEYSAFKL-ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 538
+A + EN+RL+ + +Q E ++L A K + ++N + ++ + +
Sbjct: 1241 QRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARF 1300
Query: 539 DEVAAQLERCD 549
DE+ Q + D
Sbjct: 1301 DELKEQHQTMD 1311
Score = 56.6 bits (135), Expect = 7e-08
Identities = 96/487 (19%), Positives = 191/487 (39%), Gaps = 60/487 (12%)
Query: 77 SEKLVSVMRLSDLSTEDDDSGH-CKMNRYDKKIDSLMNAVGCLKSE----VKMQKGERQM 131
S++L V +L ++DDSG K + + +S + +K E ++ Q E+
Sbjct: 932 SQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKAS 991
Query: 132 AKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKK-----HLQQEKE 186
R LE + L++ L + + E L+++ + + + K+ H + E
Sbjct: 992 LNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATME 1051
Query: 187 CLMSK--LVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTF 244
L K +E E + AA + LK+ + L+T+ + I TL +Q L + +T
Sbjct: 1052 LLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTL 1111
Query: 245 EETNRTLR-----------------DLLREQHCKEDSER--LMEQQGALLKRLAEADSEK 285
+ L+ LL+ H +++E L QQ L +
Sbjct: 1112 QTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDH 1171
Query: 286 ARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL---QAQLRSKEAENS 342
L L + + E E L+++ C K + K + G + +A+L +E
Sbjct: 1172 EHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEERE---- 1227
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAE 402
++ ER Q + A+ + + +G+ D+ + + EY E
Sbjct: 1228 ----KVLTTEREALQQEQRTNALAMGENQ-RLRGELDRVNFL--------HHQLKGEY-E 1273
Query: 403 QLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE 462
+LH + + A L W++R++++ ++ +++ + L++ L + LEE
Sbjct: 1274 ELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEE 1333
Query: 463 KMREDRDSLVERLHRQTAEYSAFKLEN-ERLKASFAPMEDKLNQAHLEVQQLKASVKNYE 521
+ S ++ L +Q +EN E+ DKLN ++L+ E
Sbjct: 1334 E-NHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLE------E 1386
Query: 522 GMIDNYK 528
++D YK
Sbjct: 1387 KIMDQYK 1393
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 90.5 bits (223), Expect = 4e-18
Identities = 113/534 (21%), Positives = 240/534 (44%), Gaps = 62/534 (11%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 173
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE-------ADSEKA 286
E L + + E NR L +LR+ K++++R ++++ +K++AE A E A
Sbjct: 2237 MEELSKLKARIEAENRAL--ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 287 RLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSKSMESMRGH---LQAQLRSKEAENS 342
RL L ++ + L +++ EK QA + A+ L E ++ Q Q R + +
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ---KERAEKSEE 399
++ Q+ E G Q E E ++ E+ + +R K + + RAQ +E A++ +
Sbjct: 2352 QMAQQLAE-ETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
AE++ +L +L E ++ +++ ++ +++ D + E R+ + + + +
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDAE------RLREAIAELER 2457
Query: 460 LEEKMREDRDSL-VERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+EK++++ L ++ QT + E + L+ SF +D L Q ++Q KA ++
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
++ +V K + +E Q ++ ++E + L M EA RRQ ++
Sbjct: 2518 QL------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME---EARRRQHEA------ 2562
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + Q++LQ E++ ++++ R+R+ + E RA
Sbjct: 2563 ---------EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/511 (20%), Positives = 206/511 (40%), Gaps = 60/511 (11%)
Query: 119 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 178
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 179 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 220
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1548
Query: 221 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 262
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 319
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 320 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 378
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 379 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 427
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
R +L E L + Q+Q EE R R AE A
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1843
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1844 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ + ++ RRQ + ++ L+
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/538 (20%), Positives = 218/538 (40%), Gaps = 55/538 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEEL-------EEVAHELAETEHENTVLRHNIERMKEE 170
L++E + + +RQ+ + L + E +E+ ELA+ E VL + R +EE
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 171 KDFTILQKKHLQQEKECLMSKLVE------------------AEMDGA---AAAKQVMAL 209
T + K + + +L E AE D A A A++V+A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 210 K-DTIG---KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
K IG +LKTE ++ ++KE ++L E R L EQ + ++
Sbjct: 1838 KLAAIGEATRLKTEAEIAL-------KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 266 RLMEQQGALLKRLAEADSEKARLLL---LLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+E++ A L++ ++++ E+ + L+ L Q + E E L + EKA A A EL
Sbjct: 1891 --IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELELE 1947
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
+ +R + + LRSKE Q + + + E + + L ++ + K +
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 383 LKKA--IRAQKERAEKSEEYAEQ---LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 437
L++ ++A+ E A + E AEQ +QLA + A L++ + V++K
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQESARQLQLAQE-----AAQKRLQAEEKAHAFAVQQKE 2062
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ + V D + + + E+ + + R+ A+ E ERLK S
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
QA ++L+ + + ++ + AD + ++ ++ K
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
++ +E+ R Q + L + L+ +A+ E Q E + + + +L
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/583 (21%), Positives = 242/583 (41%), Gaps = 105/583 (18%)
Query: 121 EVKMQKGERQMAKRFLEERKEELE---EVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
EV+ K + + A+R E ++E ++A E A+ + H ++E++
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL---- 2065
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
++ LQQE+ L EAE AA + ++ + + E + + R K+
Sbjct: 2066 QQTLQQEQSVLDQLRGEAE----AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL--------------------LKR 277
++ + L +E +E + R +Q AL L++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 278 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQ 333
A+ + E L L L++ D + L +E+Q KA+A A S++ + + S+R ++
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Query: 334 LRSK---EAENSRLCMQIKNLERSGNQHKAE-----------VEAIMEQLKELKQKGDRD 379
+ K EAEN L ++ K+ + Q +AE + ++ L+Q + D
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 380 ------------KESLKKA-----IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-- 420
KE ++ ++A+ E ++ +E A++ +L + +A+ L+
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 421 ------TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSL 471
TLE+ R R ++ E L+L RV ++ Q EE + R+ + +
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKL-------RVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 472 VERLHR---QTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+LHR T E E + ++L +A E+++ K ++ E + K
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLK 2472
Query: 529 SQVMKT----RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ--FQSQLADLQQLPD 582
S+ M+T +L + A Q +++ +L+ E E E A+ + FQ ++A QQL +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 583 ILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
E Q Q Q E++ L A + + R R + ++G
Sbjct: 2533 ----------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/363 (22%), Positives = 158/363 (43%), Gaps = 31/363 (8%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
D N +R ++ + + E S RL L+ ED + K+
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEE 170
+ LK+E ++ + ++++A+ +E+ E++A +LAE E +
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE------------ETQGFQ 2365
Query: 171 KDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL 230
+ +++ L+ E KL AEM A A + A + + +++ T++
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--A 2423
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
T++K L+Q L + + + LRE + + E+ QQ A L +L + + +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 291 LLQDKD-------KEVEELLQE---IQCEKAQAKT--ASELSKSMESMRGHLQAQLRSKE 338
LLQ+ E + LLQ I+ EKA+ + E++K+ + +R Q Q + E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQME 2542
Query: 339 AENSRLCMQIKNLERSGNQHKAE--VEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 396
E RL ++ R QH+AE V E+L++L+Q+ + +E L + + +E+ +
Sbjct: 2543 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Query: 397 SEE 399
EE
Sbjct: 2601 LEE 2603
Score = 57.8 bits (138), Expect = 3e-08
Identities = 102/525 (19%), Positives = 222/525 (42%), Gaps = 70/525 (13%)
Query: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 169
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 170 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 210
E L+K Q E + + E+ GA +V +
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 270
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1232
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1233 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 331 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 378
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 379 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 437
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1343 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1396
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 490
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1397 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
++ E + A E+Q L+A + E + + + R + + + + + +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 551 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E L + E EAAR + Q L L++L + E +L + +
Sbjct: 1516 E---LASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQAE 1556
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/464 (19%), Positives = 200/464 (43%), Gaps = 26/464 (5%)
Query: 122 VKMQKGERQM-AKRFLEERKEELEEVAHELAETE---HENTVLRHNIERMKEEKDFTILQ 177
++ + GER + +R+ E + LE LA+T+ E L + +E D
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI---GKLKTEKQMTCTDINTLTRQK 234
+ ++ +E + + + +Q AL + I G+ E Q +
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 235 ELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
EL +L T++ + ++ + SE ++++ L +E + ++ + + +
Sbjct: 1283 EL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 295 KDKEVEE---LLQEIQCEKAQ--AKTASELSKSMESMRGHLQAQLRS-KEAENSRLCMQ- 347
+ +EE L ++ + E+ + A+ + L K + H QA+ ++ +EA+ + MQ
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399
Query: 348 -IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ E + + + +I E+L++L+Q + + ++ + A + + EE + +
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
QL + A L++ R+R + +K + E L +V D +++ E ++
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMID 525
+ E + A LE RL+A A E +L QA +E +Q++ +++ +
Sbjct: 1520 RVKAEAEAAREKQRALQA--LEELRLQAEEA--ERRLRQAEVERARQVQVALETAQ---R 1572
Query: 526 NYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ ++++ R E AQLER +E + ++ +E E +Q
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 90.5 bits (223), Expect = 4e-18
Identities = 113/534 (21%), Positives = 240/534 (44%), Gaps = 62/534 (11%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 173
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE-------ADSEKA 286
E L + + E NR L +LR+ K++++R ++++ +K++AE A E A
Sbjct: 2241 MEELSKLKARIEAENRAL--ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2295
Query: 287 RLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSKSMESMRGH---LQAQLRSKEAENS 342
RL L ++ + L +++ EK QA + A+ L E ++ Q Q R + +
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ---KERAEKSEE 399
++ Q+ E G Q E E ++ E+ + +R K + + RAQ +E A++ +
Sbjct: 2356 QMAQQLAE-ETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
AE++ +L +L E ++ +++ ++ +++ D + E R+ + + + +
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDAE------RLREAIAELER 2461
Query: 460 LEEKMREDRDSL-VERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+EK++++ L ++ QT + E + L+ SF +D L Q ++Q KA ++
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
++ +V K + +E Q ++ ++E + L M EA RRQ ++
Sbjct: 2522 QL------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME---EARRRQHEA------ 2566
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + Q++LQ E++ ++++ R+R+ + E RA
Sbjct: 2567 ---------EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/511 (20%), Positives = 206/511 (40%), Gaps = 60/511 (11%)
Query: 119 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 178
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493
Query: 179 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 220
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1552
Query: 221 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 262
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 319
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1613 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Query: 320 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 378
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 379 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 427
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1732 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1791
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
R +L E L + Q+Q EE R R AE A
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1847
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1848 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ + ++ RRQ + ++ L+
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALK 1935
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/538 (20%), Positives = 218/538 (40%), Gaps = 55/538 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEEL-------EEVAHELAETEHENTVLRHNIERMKEE 170
L++E + + +RQ+ + L + E +E+ ELA+ E VL + R +EE
Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781
Query: 171 KDFTILQKKHLQQEKECLMSKLVE------------------AEMDGA---AAAKQVMAL 209
T + K + + +L E AE D A A A++V+A
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841
Query: 210 K-DTIG---KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
K IG +LKTE ++ ++KE ++L E R L EQ + ++
Sbjct: 1842 KLAAIGEATRLKTEAEIAL-------KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894
Query: 266 RLMEQQGALLKRLAEADSEKARLLL---LLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+E++ A L++ ++++ E+ + L+ L Q + E E L + EKA A A EL
Sbjct: 1895 --IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELELE 1951
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
+ +R + + LRSKE Q + + + E + + L ++ + K +
Sbjct: 1952 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2011
Query: 383 LKKA--IRAQKERAEKSEEYAEQ---LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 437
L++ ++A+ E A + E AEQ +QLA + A L++ + V++K
Sbjct: 2012 LEEVERLKAKVEEARRLRERAEQESARQLQLAQE-----AAQKRLQAEEKAHAFAVQQKE 2066
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ + V D + + + E+ + + R+ A+ E ERLK S
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2126
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
QA ++L+ + + ++ + AD + ++ ++ K
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
++ +E+ R Q + L + L+ +A+ E Q E + + + +L
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/583 (21%), Positives = 242/583 (41%), Gaps = 105/583 (18%)
Query: 121 EVKMQKGERQMAKRFLEERKEELE---EVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
EV+ K + + A+R E ++E ++A E A+ + H ++E++
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL---- 2069
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
++ LQQE+ L EAE AA + ++ + + E + + R K+
Sbjct: 2070 QQTLQQEQSVLDQLRGEAE----AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL--------------------LKR 277
++ + L +E +E + R +Q AL L++
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 278 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQ 333
A+ + E L L L++ D + L +E+Q KA+A A S++ + + S+R ++
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244
Query: 334 LRSK---EAENSRLCMQIKNLERSGNQHKAE-----------VEAIMEQLKELKQKGDRD 379
+ K EAEN L ++ K+ + Q +AE + ++ L+Q + D
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2304
Query: 380 ------------KESLKKA-----IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-- 420
KE ++ ++A+ E ++ +E A++ +L + +A+ L+
Sbjct: 2305 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2364
Query: 421 ------TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSL 471
TLE+ R R ++ E L+L RV ++ Q EE + R+ + +
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKL-------RVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 472 VERLHR---QTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+LHR T E E + ++L +A E+++ K ++ E + K
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLK 2476
Query: 529 SQVMKT----RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ--FQSQLADLQQLPD 582
S+ M+T +L + A Q +++ +L+ E E E A+ + FQ ++A QQL +
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 583 ILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
E Q Q Q E++ L A + + R R + ++G
Sbjct: 2537 ----------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/363 (22%), Positives = 158/363 (43%), Gaps = 31/363 (8%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
D N +R ++ + + E S RL L+ ED + K+
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEE 170
+ LK+E ++ + ++++A+ +E+ E++A +LAE E +
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE------------ETQGFQ 2369
Query: 171 KDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL 230
+ +++ L+ E KL AEM A A + A + + +++ T++
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--A 2427
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
T++K L+Q L + + + LRE + + E+ QQ A L +L + + +
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487
Query: 291 LLQDKD-------KEVEELLQE---IQCEKAQAKT--ASELSKSMESMRGHLQAQLRSKE 338
LLQ+ E + LLQ I+ EKA+ + E++K+ + +R Q Q + E
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQME 2546
Query: 339 AENSRLCMQIKNLERSGNQHKAE--VEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 396
E RL ++ R QH+AE V E+L++L+Q+ + +E L + + +E+ +
Sbjct: 2547 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2604
Query: 397 SEE 399
EE
Sbjct: 2605 LEE 2607
Score = 57.8 bits (138), Expect = 3e-08
Identities = 102/525 (19%), Positives = 222/525 (42%), Gaps = 70/525 (13%)
Query: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 169
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1063 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1122
Query: 170 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 210
E L+K Q E + + E+ GA +V +
Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1182
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 270
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1236
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1237 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286
Query: 331 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 378
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346
Query: 379 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 437
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1347 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1400
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 490
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1401 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
++ E + A E+Q L+A + E + + + R + + + + + +
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 551 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E L + E EAAR + Q L L++L + E +L + +
Sbjct: 1520 E---LASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQAE 1560
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/464 (19%), Positives = 200/464 (43%), Gaps = 26/464 (5%)
Query: 122 VKMQKGERQM-AKRFLEERKEELEEVAHELAETE---HENTVLRHNIERMKEEKDFTILQ 177
++ + GER + +R+ E + LE LA+T+ E L + +E D
Sbjct: 1167 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1226
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI---GKLKTEKQMTCTDINTLTRQK 234
+ ++ +E + + + +Q AL + I G+ E Q +
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286
Query: 235 ELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
EL +L T++ + ++ + SE ++++ L +E + ++ + + +
Sbjct: 1287 EL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1343
Query: 295 KDKEVEE---LLQEIQCEKAQ--AKTASELSKSMESMRGHLQAQLRS-KEAENSRLCMQ- 347
+ +EE L ++ + E+ + A+ + L K + H QA+ ++ +EA+ + MQ
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1403
Query: 348 -IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ E + + + +I E+L++L+Q + + ++ + A + + EE + +
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
QL + A L++ R+R + +K + E L +V D +++ E ++
Sbjct: 1464 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMID 525
+ E + A LE RL+A A E +L QA +E +Q++ +++ +
Sbjct: 1524 RVKAEAEAAREKQRALQA--LEELRLQAEEA--ERRLRQAEVERARQVQVALETAQ---R 1576
Query: 526 NYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ ++++ R E AQLER +E + ++ +E E +Q
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 90.5 bits (223), Expect = 4e-18
Identities = 113/534 (21%), Positives = 240/534 (44%), Gaps = 62/534 (11%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 173
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE-------ADSEKA 286
E L + + E NR L +LR+ K++++R ++++ +K++AE A E A
Sbjct: 2237 MEELSKLKARIEAENRAL--ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 287 RLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSKSMESMRGH---LQAQLRSKEAENS 342
RL L ++ + L +++ EK QA + A+ L E ++ Q Q R + +
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ---KERAEKSEE 399
++ Q+ E G Q E E ++ E+ + +R K + + RAQ +E A++ +
Sbjct: 2352 QMAQQLAE-ETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
AE++ +L +L E ++ +++ ++ +++ D + E R+ + + + +
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDAE------RLREAIAELER 2457
Query: 460 LEEKMREDRDSL-VERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+EK++++ L ++ QT + E + L+ SF +D L Q ++Q KA ++
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
++ +V K + +E Q ++ ++E + L M EA RRQ ++
Sbjct: 2518 QL------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME---EARRRQHEA------ 2562
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + Q++LQ E++ ++++ R+R+ + E RA
Sbjct: 2563 ---------EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/511 (20%), Positives = 206/511 (40%), Gaps = 60/511 (11%)
Query: 119 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 178
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 179 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 220
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1548
Query: 221 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 262
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 319
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 320 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 378
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 379 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 427
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
R +L E L + Q+Q EE R R AE A
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1843
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1844 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ + ++ RRQ + ++ L+
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/538 (20%), Positives = 218/538 (40%), Gaps = 55/538 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEEL-------EEVAHELAETEHENTVLRHNIERMKEE 170
L++E + + +RQ+ + L + E +E+ ELA+ E VL + R +EE
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 171 KDFTILQKKHLQQEKECLMSKLVE------------------AEMDGA---AAAKQVMAL 209
T + K + + +L E AE D A A A++V+A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 210 K-DTIG---KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
K IG +LKTE ++ ++KE ++L E R L EQ + ++
Sbjct: 1838 KLAAIGEATRLKTEAEIAL-------KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 266 RLMEQQGALLKRLAEADSEKARLLL---LLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+E++ A L++ ++++ E+ + L+ L Q + E E L + EKA A A EL
Sbjct: 1891 --IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELELE 1947
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
+ +R + + LRSKE Q + + + E + + L ++ + K +
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 383 LKKA--IRAQKERAEKSEEYAEQ---LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 437
L++ ++A+ E A + E AEQ +QLA + A L++ + V++K
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQESARQLQLAQE-----AAQKRLQAEEKAHAFAVQQKE 2062
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ + V D + + + E+ + + R+ A+ E ERLK S
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
QA ++L+ + + ++ + AD + ++ ++ K
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
++ +E+ R Q + L + L+ +A+ E Q E + + + +L
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/583 (21%), Positives = 242/583 (41%), Gaps = 105/583 (18%)
Query: 121 EVKMQKGERQMAKRFLEERKEELE---EVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
EV+ K + + A+R E ++E ++A E A+ + H ++E++
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL---- 2065
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
++ LQQE+ L EAE AA + ++ + + E + + R K+
Sbjct: 2066 QQTLQQEQSVLDQLRGEAE----AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL--------------------LKR 277
++ + L +E +E + R +Q AL L++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 278 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQ 333
A+ + E L L L++ D + L +E+Q KA+A A S++ + + S+R ++
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Query: 334 LRSK---EAENSRLCMQIKNLERSGNQHKAE-----------VEAIMEQLKELKQKGDRD 379
+ K EAEN L ++ K+ + Q +AE + ++ L+Q + D
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 380 ------------KESLKKA-----IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-- 420
KE ++ ++A+ E ++ +E A++ +L + +A+ L+
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 421 ------TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSL 471
TLE+ R R ++ E L+L RV ++ Q EE + R+ + +
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKL-------RVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 472 VERLHR---QTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+LHR T E E + ++L +A E+++ K ++ E + K
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLK 2472
Query: 529 SQVMKT----RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ--FQSQLADLQQLPD 582
S+ M+T +L + A Q +++ +L+ E E E A+ + FQ ++A QQL +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 583 ILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
E Q Q Q E++ L A + + R R + ++G
Sbjct: 2533 ----------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/363 (22%), Positives = 158/363 (43%), Gaps = 31/363 (8%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
D N +R ++ + + E S RL L+ ED + K+
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEE 170
+ LK+E ++ + ++++A+ +E+ E++A +LAE E +
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE------------ETQGFQ 2365
Query: 171 KDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL 230
+ +++ L+ E KL AEM A A + A + + +++ T++
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--A 2423
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
T++K L+Q L + + + LRE + + E+ QQ A L +L + + +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 291 LLQDKD-------KEVEELLQE---IQCEKAQAKT--ASELSKSMESMRGHLQAQLRSKE 338
LLQ+ E + LLQ I+ EKA+ + E++K+ + +R Q Q + E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQME 2542
Query: 339 AENSRLCMQIKNLERSGNQHKAE--VEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 396
E RL ++ R QH+AE V E+L++L+Q+ + +E L + + +E+ +
Sbjct: 2543 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Query: 397 SEE 399
EE
Sbjct: 2601 LEE 2603
Score = 57.8 bits (138), Expect = 3e-08
Identities = 102/525 (19%), Positives = 222/525 (42%), Gaps = 70/525 (13%)
Query: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 169
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 170 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 210
E L+K Q E + + E+ GA +V +
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 270
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1232
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1233 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 331 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 378
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 379 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 437
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1343 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1396
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 490
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1397 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
++ E + A E+Q L+A + E + + + R + + + + + +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 551 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E L + E EAAR + Q L L++L + E +L + +
Sbjct: 1516 E---LASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQAE 1556
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/464 (19%), Positives = 200/464 (43%), Gaps = 26/464 (5%)
Query: 122 VKMQKGERQM-AKRFLEERKEELEEVAHELAETE---HENTVLRHNIERMKEEKDFTILQ 177
++ + GER + +R+ E + LE LA+T+ E L + +E D
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI---GKLKTEKQMTCTDINTLTRQK 234
+ ++ +E + + + +Q AL + I G+ E Q +
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 235 ELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
EL +L T++ + ++ + SE ++++ L +E + ++ + + +
Sbjct: 1283 EL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 295 KDKEVEE---LLQEIQCEKAQ--AKTASELSKSMESMRGHLQAQLRS-KEAENSRLCMQ- 347
+ +EE L ++ + E+ + A+ + L K + H QA+ ++ +EA+ + MQ
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399
Query: 348 -IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ E + + + +I E+L++L+Q + + ++ + A + + EE + +
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
QL + A L++ R+R + +K + E L +V D +++ E ++
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMID 525
+ E + A LE RL+A A E +L QA +E +Q++ +++ +
Sbjct: 1520 RVKAEAEAAREKQRALQA--LEELRLQAEEA--ERRLRQAEVERARQVQVALETAQ---R 1572
Query: 526 NYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ ++++ R E AQLER +E + ++ +E E +Q
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 90.5 bits (223), Expect = 4e-18
Identities = 113/534 (21%), Positives = 240/534 (44%), Gaps = 62/534 (11%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 173
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE-------ADSEKA 286
E L + + E NR L +LR+ K++++R ++++ +K++AE A E A
Sbjct: 2205 MEELSKLKARIEAENRAL--ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2259
Query: 287 RLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSKSMESMRGH---LQAQLRSKEAENS 342
RL L ++ + L +++ EK QA + A+ L E ++ Q Q R + +
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ---KERAEKSEE 399
++ Q+ E G Q E E ++ E+ + +R K + + RAQ +E A++ +
Sbjct: 2320 QMAQQLAE-ETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
AE++ +L +L E ++ +++ ++ +++ D + E R+ + + + +
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDAE------RLREAIAELER 2425
Query: 460 LEEKMREDRDSL-VERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+EK++++ L ++ QT + E + L+ SF +D L Q ++Q KA ++
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
++ +V K + +E Q ++ ++E + L M EA RRQ ++
Sbjct: 2486 QL------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME---EARRRQHEA------ 2530
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + Q++LQ E++ ++++ R+R+ + E RA
Sbjct: 2531 ---------EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/511 (20%), Positives = 206/511 (40%), Gaps = 60/511 (11%)
Query: 119 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 178
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457
Query: 179 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 220
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1516
Query: 221 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 262
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 319
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1577 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Query: 320 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 378
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 379 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 427
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1696 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1755
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
R +L E L + Q+Q EE R R AE A
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1811
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1812 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ + ++ RRQ + ++ L+
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALK 1899
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/538 (20%), Positives = 218/538 (40%), Gaps = 55/538 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEEL-------EEVAHELAETEHENTVLRHNIERMKEE 170
L++E + + +RQ+ + L + E +E+ ELA+ E VL + R +EE
Sbjct: 1686 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1745
Query: 171 KDFTILQKKHLQQEKECLMSKLVE------------------AEMDGA---AAAKQVMAL 209
T + K + + +L E AE D A A A++V+A
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805
Query: 210 K-DTIG---KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
K IG +LKTE ++ ++KE ++L E R L EQ + ++
Sbjct: 1806 KLAAIGEATRLKTEAEIAL-------KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858
Query: 266 RLMEQQGALLKRLAEADSEKARLLL---LLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+E++ A L++ ++++ E+ + L+ L Q + E E L + EKA A A EL
Sbjct: 1859 --IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELELE 1915
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
+ +R + + LRSKE Q + + + E + + L ++ + K +
Sbjct: 1916 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1975
Query: 383 LKKA--IRAQKERAEKSEEYAEQ---LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 437
L++ ++A+ E A + E AEQ +QLA + A L++ + V++K
Sbjct: 1976 LEEVERLKAKVEEARRLRERAEQESARQLQLAQE-----AAQKRLQAEEKAHAFAVQQKE 2030
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ + V D + + + E+ + + R+ A+ E ERLK S
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2090
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
QA ++L+ + + ++ + AD + ++ ++ K
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2150
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
++ +E+ R Q + L + L+ +A+ E Q E + + + +L
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/583 (21%), Positives = 242/583 (41%), Gaps = 105/583 (18%)
Query: 121 EVKMQKGERQMAKRFLEERKEELE---EVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
EV+ K + + A+R E ++E ++A E A+ + H ++E++
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL---- 2033
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
++ LQQE+ L EAE AA + ++ + + E + + R K+
Sbjct: 2034 QQTLQQEQSVLDQLRGEAE----AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL--------------------LKR 277
++ + L +E +E + R +Q AL L++
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 278 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQ 333
A+ + E L L L++ D + L +E+Q KA+A A S++ + + S+R ++
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208
Query: 334 LRSK---EAENSRLCMQIKNLERSGNQHKAE-----------VEAIMEQLKELKQKGDRD 379
+ K EAEN L ++ K+ + Q +AE + ++ L+Q + D
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2268
Query: 380 ------------KESLKKA-----IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-- 420
KE ++ ++A+ E ++ +E A++ +L + +A+ L+
Sbjct: 2269 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2328
Query: 421 ------TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSL 471
TLE+ R R ++ E L+L RV ++ Q EE + R+ + +
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKL-------RVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 472 VERLHR---QTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+LHR T E E + ++L +A E+++ K ++ E + K
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLK 2440
Query: 529 SQVMKT----RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ--FQSQLADLQQLPD 582
S+ M+T +L + A Q +++ +L+ E E E A+ + FQ ++A QQL +
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 583 ILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
E Q Q Q E++ L A + + R R + ++G
Sbjct: 2501 ----------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/363 (22%), Positives = 158/363 (43%), Gaps = 31/363 (8%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
D N +R ++ + + E S RL L+ ED + K+
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2285
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEE 170
+ LK+E ++ + ++++A+ +E+ E++A +LAE E +
Sbjct: 2286 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE------------ETQGFQ 2333
Query: 171 KDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL 230
+ +++ L+ E KL AEM A A + A + + +++ T++
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--A 2391
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
T++K L+Q L + + + LRE + + E+ QQ A L +L + + +
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2451
Query: 291 LLQDKD-------KEVEELLQE---IQCEKAQAKT--ASELSKSMESMRGHLQAQLRSKE 338
LLQ+ E + LLQ I+ EKA+ + E++K+ + +R Q Q + E
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQME 2510
Query: 339 AENSRLCMQIKNLERSGNQHKAE--VEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 396
E RL ++ R QH+AE V E+L++L+Q+ + +E L + + +E+ +
Sbjct: 2511 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2568
Query: 397 SEE 399
EE
Sbjct: 2569 LEE 2571
Score = 57.8 bits (138), Expect = 3e-08
Identities = 102/525 (19%), Positives = 222/525 (42%), Gaps = 70/525 (13%)
Query: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 169
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1027 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1086
Query: 170 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 210
E L+K Q E + + E+ GA +V +
Sbjct: 1087 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1146
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 270
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1200
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1201 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250
Query: 331 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 378
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310
Query: 379 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 437
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1311 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1364
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 490
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1365 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
++ E + A E+Q L+A + E + + + R + + + + + +
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 551 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E L + E EAAR + Q L L++L + E +L + +
Sbjct: 1484 E---LASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQAE 1524
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/464 (19%), Positives = 200/464 (43%), Gaps = 26/464 (5%)
Query: 122 VKMQKGERQM-AKRFLEERKEELEEVAHELAETE---HENTVLRHNIERMKEEKDFTILQ 177
++ + GER + +R+ E + LE LA+T+ E L + +E D
Sbjct: 1131 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1190
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI---GKLKTEKQMTCTDINTLTRQK 234
+ ++ +E + + + +Q AL + I G+ E Q +
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250
Query: 235 ELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
EL +L T++ + ++ + SE ++++ L +E + ++ + + +
Sbjct: 1251 EL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1307
Query: 295 KDKEVEE---LLQEIQCEKAQ--AKTASELSKSMESMRGHLQAQLRS-KEAENSRLCMQ- 347
+ +EE L ++ + E+ + A+ + L K + H QA+ ++ +EA+ + MQ
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1367
Query: 348 -IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ E + + + +I E+L++L+Q + + ++ + A + + EE + +
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
QL + A L++ R+R + +K + E L +V D +++ E ++
Sbjct: 1428 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1487
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMID 525
+ E + A LE RL+A A E +L QA +E +Q++ +++ +
Sbjct: 1488 RVKAEAEAAREKQRALQA--LEELRLQAEEA--ERRLRQAEVERARQVQVALETAQ---R 1540
Query: 526 NYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ ++++ R E AQLER +E + ++ +E E +Q
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 90.5 bits (223), Expect = 4e-18
Identities = 113/534 (21%), Positives = 240/534 (44%), Gaps = 62/534 (11%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 173
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE-------ADSEKA 286
E L + + E NR L +LR+ K++++R ++++ +K++AE A E A
Sbjct: 2374 MEELSKLKARIEAENRAL--ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428
Query: 287 RLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSKSMESMRGH---LQAQLRSKEAENS 342
RL L ++ + L +++ EK QA + A+ L E ++ Q Q R + +
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ---KERAEKSEE 399
++ Q+ E G Q E E ++ E+ + +R K + + RAQ +E A++ +
Sbjct: 2489 QMAQQLAE-ETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
AE++ +L +L E ++ +++ ++ +++ D + E R+ + + + +
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDAE------RLREAIAELER 2594
Query: 460 LEEKMREDRDSL-VERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+EK++++ L ++ QT + E + L+ SF +D L Q ++Q KA ++
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
++ +V K + +E Q ++ ++E + L M EA RRQ ++
Sbjct: 2655 QL------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME---EARRRQHEA------ 2699
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + Q++LQ E++ ++++ R+R+ + E RA
Sbjct: 2700 ---------EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/511 (20%), Positives = 206/511 (40%), Gaps = 60/511 (11%)
Query: 119 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 178
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626
Query: 179 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 220
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1685
Query: 221 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 262
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 319
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1746 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Query: 320 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 378
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 379 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 427
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1924
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
R +L E L + Q+Q EE R R AE A
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1980
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1981 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ + ++ RRQ + ++ L+
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALK 2068
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/538 (20%), Positives = 218/538 (40%), Gaps = 55/538 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEEL-------EEVAHELAETEHENTVLRHNIERMKEE 170
L++E + + +RQ+ + L + E +E+ ELA+ E VL + R +EE
Sbjct: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914
Query: 171 KDFTILQKKHLQQEKECLMSKLVE------------------AEMDGA---AAAKQVMAL 209
T + K + + +L E AE D A A A++V+A
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974
Query: 210 K-DTIG---KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
K IG +LKTE ++ ++KE ++L E R L EQ + ++
Sbjct: 1975 KLAAIGEATRLKTEAEIAL-------KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027
Query: 266 RLMEQQGALLKRLAEADSEKARLLL---LLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+E++ A L++ ++++ E+ + L+ L Q + E E L + EKA A A EL
Sbjct: 2028 --IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELELE 2084
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
+ +R + + LRSKE Q + + + E + + L ++ + K +
Sbjct: 2085 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144
Query: 383 LKKA--IRAQKERAEKSEEYAEQ---LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 437
L++ ++A+ E A + E AEQ +QLA + A L++ + V++K
Sbjct: 2145 LEEVERLKAKVEEARRLRERAEQESARQLQLAQE-----AAQKRLQAEEKAHAFAVQQKE 2199
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ + V D + + + E+ + + R+ A+ E ERLK S
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2259
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
QA ++L+ + + ++ + AD + ++ ++ K
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2319
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
++ +E+ R Q + L + L+ +A+ E Q E + + + +L
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/583 (21%), Positives = 242/583 (41%), Gaps = 105/583 (18%)
Query: 121 EVKMQKGERQMAKRFLEERKEELE---EVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
EV+ K + + A+R E ++E ++A E A+ + H ++E++
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL---- 2202
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
++ LQQE+ L EAE AA + ++ + + E + + R K+
Sbjct: 2203 QQTLQQEQSVLDQLRGEAE----AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL--------------------LKR 277
++ + L +E +E + R +Q AL L++
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 278 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQ 333
A+ + E L L L++ D + L +E+Q KA+A A S++ + + S+R ++
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377
Query: 334 LRSK---EAENSRLCMQIKNLERSGNQHKAE-----------VEAIMEQLKELKQKGDRD 379
+ K EAEN L ++ K+ + Q +AE + ++ L+Q + D
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2437
Query: 380 ------------KESLKKA-----IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-- 420
KE ++ ++A+ E ++ +E A++ +L + +A+ L+
Sbjct: 2438 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2497
Query: 421 ------TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSL 471
TLE+ R R ++ E L+L RV ++ Q EE + R+ + +
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKL-------RVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 472 VERLHR---QTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+LHR T E E + ++L +A E+++ K ++ E + K
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLK 2609
Query: 529 SQVMKT----RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ--FQSQLADLQQLPD 582
S+ M+T +L + A Q +++ +L+ E E E A+ + FQ ++A QQL +
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 583 ILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
E Q Q Q E++ L A + + R R + ++G
Sbjct: 2670 ----------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/363 (22%), Positives = 158/363 (43%), Gaps = 31/363 (8%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
D N +R ++ + + E S RL L+ ED + K+
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEE 170
+ LK+E ++ + ++++A+ +E+ E++A +LAE E +
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE------------ETQGFQ 2502
Query: 171 KDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL 230
+ +++ L+ E KL AEM A A + A + + +++ T++
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--A 2560
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
T++K L+Q L + + + LRE + + E+ QQ A L +L + + +
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620
Query: 291 LLQDKD-------KEVEELLQE---IQCEKAQAKT--ASELSKSMESMRGHLQAQLRSKE 338
LLQ+ E + LLQ I+ EKA+ + E++K+ + +R Q Q + E
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQME 2679
Query: 339 AENSRLCMQIKNLERSGNQHKAE--VEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 396
E RL ++ R QH+AE V E+L++L+Q+ + +E L + + +E+ +
Sbjct: 2680 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2737
Query: 397 SEE 399
EE
Sbjct: 2738 LEE 2740
Score = 57.8 bits (138), Expect = 3e-08
Identities = 102/525 (19%), Positives = 222/525 (42%), Gaps = 70/525 (13%)
Query: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 169
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1196 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1255
Query: 170 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 210
E L+K Q E + + E+ GA +V +
Sbjct: 1256 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1315
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 270
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1369
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1370 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419
Query: 331 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 378
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479
Query: 379 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 437
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1480 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1533
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 490
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1534 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
++ E + A E+Q L+A + E + + + R + + + + + +
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 551 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E L + E EAAR + Q L L++L + E +L + +
Sbjct: 1653 E---LASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQAE 1693
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/464 (19%), Positives = 200/464 (43%), Gaps = 26/464 (5%)
Query: 122 VKMQKGERQM-AKRFLEERKEELEEVAHELAETE---HENTVLRHNIERMKEEKDFTILQ 177
++ + GER + +R+ E + LE LA+T+ E L + +E D
Sbjct: 1300 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1359
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI---GKLKTEKQMTCTDINTLTRQK 234
+ ++ +E + + + +Q AL + I G+ E Q +
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419
Query: 235 ELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
EL +L T++ + ++ + SE ++++ L +E + ++ + + +
Sbjct: 1420 EL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1476
Query: 295 KDKEVEE---LLQEIQCEKAQ--AKTASELSKSMESMRGHLQAQLRS-KEAENSRLCMQ- 347
+ +EE L ++ + E+ + A+ + L K + H QA+ ++ +EA+ + MQ
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1536
Query: 348 -IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ E + + + +I E+L++L+Q + + ++ + A + + EE + +
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
QL + A L++ R+R + +K + E L +V D +++ E ++
Sbjct: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1656
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMID 525
+ E + A LE RL+A A E +L QA +E +Q++ +++ +
Sbjct: 1657 RVKAEAEAAREKQRALQA--LEELRLQAEEA--ERRLRQAEVERARQVQVALETAQ---R 1709
Query: 526 NYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ ++++ R E AQLER +E + ++ +E E +Q
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 90.5 bits (223), Expect = 4e-18
Identities = 113/534 (21%), Positives = 240/534 (44%), Gaps = 62/534 (11%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 173
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE-------ADSEKA 286
E L + + E NR L +LR+ K++++R ++++ +K++AE A E A
Sbjct: 2215 MEELSKLKARIEAENRAL--ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2269
Query: 287 RLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSKSMESMRGH---LQAQLRSKEAENS 342
RL L ++ + L +++ EK QA + A+ L E ++ Q Q R + +
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ---KERAEKSEE 399
++ Q+ E G Q E E ++ E+ + +R K + + RAQ +E A++ +
Sbjct: 2330 QMAQQLAE-ETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
AE++ +L +L E ++ +++ ++ +++ D + E R+ + + + +
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDAE------RLREAIAELER 2435
Query: 460 LEEKMREDRDSL-VERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+EK++++ L ++ QT + E + L+ SF +D L Q ++Q KA ++
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
++ +V K + +E Q ++ ++E + L M EA RRQ ++
Sbjct: 2496 QL------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME---EARRRQHEA------ 2540
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + Q++LQ E++ ++++ R+R+ + E RA
Sbjct: 2541 ---------EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/511 (20%), Positives = 206/511 (40%), Gaps = 60/511 (11%)
Query: 119 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 178
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467
Query: 179 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 220
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1526
Query: 221 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 262
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 319
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1587 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Query: 320 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 378
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 379 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 427
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1765
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
R +L E L + Q+Q EE R R AE A
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1821
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1822 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ + ++ RRQ + ++ L+
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALK 1909
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/538 (20%), Positives = 218/538 (40%), Gaps = 55/538 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEEL-------EEVAHELAETEHENTVLRHNIERMKEE 170
L++E + + +RQ+ + L + E +E+ ELA+ E VL + R +EE
Sbjct: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755
Query: 171 KDFTILQKKHLQQEKECLMSKLVE------------------AEMDGA---AAAKQVMAL 209
T + K + + +L E AE D A A A++V+A
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815
Query: 210 K-DTIG---KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
K IG +LKTE ++ ++KE ++L E R L EQ + ++
Sbjct: 1816 KLAAIGEATRLKTEAEIAL-------KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868
Query: 266 RLMEQQGALLKRLAEADSEKARLLL---LLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+E++ A L++ ++++ E+ + L+ L Q + E E L + EKA A A EL
Sbjct: 1869 --IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELELE 1925
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
+ +R + + LRSKE Q + + + E + + L ++ + K +
Sbjct: 1926 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985
Query: 383 LKKA--IRAQKERAEKSEEYAEQ---LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 437
L++ ++A+ E A + E AEQ +QLA + A L++ + V++K
Sbjct: 1986 LEEVERLKAKVEEARRLRERAEQESARQLQLAQE-----AAQKRLQAEEKAHAFAVQQKE 2040
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ + V D + + + E+ + + R+ A+ E ERLK S
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2100
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
QA ++L+ + + ++ + AD + ++ ++ K
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
++ +E+ R Q + L + L+ +A+ E Q E + + + +L
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/583 (21%), Positives = 242/583 (41%), Gaps = 105/583 (18%)
Query: 121 EVKMQKGERQMAKRFLEERKEELE---EVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
EV+ K + + A+R E ++E ++A E A+ + H ++E++
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL---- 2043
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
++ LQQE+ L EAE AA + ++ + + E + + R K+
Sbjct: 2044 QQTLQQEQSVLDQLRGEAE----AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL--------------------LKR 277
++ + L +E +E + R +Q AL L++
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 278 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQ 333
A+ + E L L L++ D + L +E+Q KA+A A S++ + + S+R ++
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218
Query: 334 LRSK---EAENSRLCMQIKNLERSGNQHKAE-----------VEAIMEQLKELKQKGDRD 379
+ K EAEN L ++ K+ + Q +AE + ++ L+Q + D
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2278
Query: 380 ------------KESLKKA-----IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-- 420
KE ++ ++A+ E ++ +E A++ +L + +A+ L+
Sbjct: 2279 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2338
Query: 421 ------TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSL 471
TLE+ R R ++ E L+L RV ++ Q EE + R+ + +
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKL-------RVAEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 472 VERLHR---QTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+LHR T E E + ++L +A E+++ K ++ E + K
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLK 2450
Query: 529 SQVMKT----RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ--FQSQLADLQQLPD 582
S+ M+T +L + A Q +++ +L+ E E E A+ + FQ ++A QQL +
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
Query: 583 ILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
E Q Q Q E++ L A + + R R + ++G
Sbjct: 2511 ----------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/363 (22%), Positives = 158/363 (43%), Gaps = 31/363 (8%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
D N +R ++ + + E S RL L+ ED + K+
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEE 170
+ LK+E ++ + ++++A+ +E+ E++A +LAE E +
Sbjct: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE------------ETQGFQ 2343
Query: 171 KDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL 230
+ +++ L+ E KL AEM A A + A + + +++ T++
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--A 2401
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
T++K L+Q L + + + LRE + + E+ QQ A L +L + + +
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2461
Query: 291 LLQDKD-------KEVEELLQE---IQCEKAQAKT--ASELSKSMESMRGHLQAQLRSKE 338
LLQ+ E + LLQ I+ EKA+ + E++K+ + +R Q Q + E
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQME 2520
Query: 339 AENSRLCMQIKNLERSGNQHKAE--VEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 396
E RL ++ R QH+AE V E+L++L+Q+ + +E L + + +E+ +
Sbjct: 2521 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2578
Query: 397 SEE 399
EE
Sbjct: 2579 LEE 2581
Score = 57.8 bits (138), Expect = 3e-08
Identities = 102/525 (19%), Positives = 222/525 (42%), Gaps = 70/525 (13%)
Query: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 169
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1037 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1096
Query: 170 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 210
E L+K Q E + + E+ GA +V +
Sbjct: 1097 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1156
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 270
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1210
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1211 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
Query: 331 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 378
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
Query: 379 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 437
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1321 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1374
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 490
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1375 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
++ E + A E+Q L+A + E + + + R + + + + + +
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 551 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E L + E EAAR + Q L L++L + E +L + +
Sbjct: 1494 E---LASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQAE 1534
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/464 (19%), Positives = 200/464 (43%), Gaps = 26/464 (5%)
Query: 122 VKMQKGERQM-AKRFLEERKEELEEVAHELAETE---HENTVLRHNIERMKEEKDFTILQ 177
++ + GER + +R+ E + LE LA+T+ E L + +E D
Sbjct: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI---GKLKTEKQMTCTDINTLTRQK 234
+ ++ +E + + + +Q AL + I G+ E Q +
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
Query: 235 ELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
EL +L T++ + ++ + SE ++++ L +E + ++ + + +
Sbjct: 1261 EL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1317
Query: 295 KDKEVEE---LLQEIQCEKAQ--AKTASELSKSMESMRGHLQAQLRS-KEAENSRLCMQ- 347
+ +EE L ++ + E+ + A+ + L K + H QA+ ++ +EA+ + MQ
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1377
Query: 348 -IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ E + + + +I E+L++L+Q + + ++ + A + + EE + +
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
QL + A L++ R+R + +K + E L +V D +++ E ++
Sbjct: 1438 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1497
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMID 525
+ E + A LE RL+A A E +L QA +E +Q++ +++ +
Sbjct: 1498 RVKAEAEAAREKQRALQA--LEELRLQAEEA--ERRLRQAEVERARQVQVALETAQ---R 1550
Query: 526 NYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ ++++ R E AQLER +E + ++ +E E +Q
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 90.5 bits (223), Expect = 4e-18
Identities = 113/534 (21%), Positives = 240/534 (44%), Gaps = 62/534 (11%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 173
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 233
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 234 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE-------ADSEKA 286
E L + + E NR L +LR+ K++++R ++++ +K++AE A E A
Sbjct: 2223 MEELSKLKARIEAENRAL--ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2277
Query: 287 RLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSKSMESMRGH---LQAQLRSKEAENS 342
RL L ++ + L +++ EK QA + A+ L E ++ Q Q R + +
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337
Query: 343 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQ---KERAEKSEE 399
++ Q+ E G Q E E ++ E+ + +R K + + RAQ +E A++ +
Sbjct: 2338 QMAQQLAE-ETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394
Query: 400 YAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 459
AE++ +L +L E ++ +++ ++ +++ D + E R+ + + + +
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDAE------RLREAIAELER 2443
Query: 460 LEEKMREDRDSL-VERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 518
+EK++++ L ++ QT + E + L+ SF +D L Q ++Q KA ++
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Query: 519 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
++ +V K + +E Q ++ ++E + L M EA RRQ ++
Sbjct: 2504 QL------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME---EARRRQHEA------ 2548
Query: 579 QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELTRA 632
E + Q++LQ E++ ++++ R+R+ + E RA
Sbjct: 2549 ---------EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/511 (20%), Positives = 206/511 (40%), Gaps = 60/511 (11%)
Query: 119 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 178
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475
Query: 179 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 220
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1534
Query: 221 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 262
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1535 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1594
Query: 263 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 319
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1595 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654
Query: 320 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 378
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 379 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 427
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1714 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1773
Query: 428 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 487
R +L E L + Q+Q EE R R AE A
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1829
Query: 488 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 547
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1830 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Query: 548 CDKENKILKDEMNKEIEAARRQFQSQLADLQ 578
+ + ++ RRQ + ++ L+
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALK 1917
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/538 (20%), Positives = 218/538 (40%), Gaps = 55/538 (10%)
Query: 118 LKSEVKMQKGERQMAKRFLEERKEEL-------EEVAHELAETEHENTVLRHNIERMKEE 170
L++E + + +RQ+ + L + E +E+ ELA+ E VL + R +EE
Sbjct: 1704 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1763
Query: 171 KDFTILQKKHLQQEKECLMSKLVE------------------AEMDGA---AAAKQVMAL 209
T + K + + +L E AE D A A A++V+A
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823
Query: 210 K-DTIG---KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE 265
K IG +LKTE ++ ++KE ++L E R L EQ + ++
Sbjct: 1824 KLAAIGEATRLKTEAEIAL-------KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876
Query: 266 RLMEQQGALLKRLAEADSEKARLLL---LLQDKDKEVEELLQEIQCEKAQAKTASELSKS 322
+E++ A L++ ++++ E+ + L+ L Q + E E L + EKA A A EL
Sbjct: 1877 --IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELELE 1933
Query: 323 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 382
+ +R + + LRSKE Q + + + E + + L ++ + K +
Sbjct: 1934 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1993
Query: 383 LKKA--IRAQKERAEKSEEYAEQ---LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 437
L++ ++A+ E A + E AEQ +QLA + A L++ + V++K
Sbjct: 1994 LEEVERLKAKVEEARRLRERAEQESARQLQLAQE-----AAQKRLQAEEKAHAFAVQQKE 2048
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 497
+ + V D + + + E+ + + R+ A+ E ERLK S
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2108
Query: 498 PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 557
QA ++L+ + + ++ + AD + ++ ++ K
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2168
Query: 558 EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 615
++ +E+ R Q + L + L+ +A+ E Q E + + + +L
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2226
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/583 (21%), Positives = 242/583 (41%), Gaps = 105/583 (18%)
Query: 121 EVKMQKGERQMAKRFLEERKEELE---EVAHELAETEHENTVLRHNIERMKEEKDFTILQ 177
EV+ K + + A+R E ++E ++A E A+ + H ++E++
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL---- 2051
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 237
++ LQQE+ L EAE AA + ++ + + E + + R K+
Sbjct: 2052 QQTLQQEQSVLDQLRGEAE----AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 238 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL--------------------LKR 277
++ + L +E +E + R +Q AL L++
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 278 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA----SELSKSMESMRGHLQAQ 333
A+ + E L L L++ D + L +E+Q KA+A A S++ + + S+R ++
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2226
Query: 334 LRSK---EAENSRLCMQIKNLERSGNQHKAE-----------VEAIMEQLKELKQKGDRD 379
+ K EAEN L ++ K+ + Q +AE + ++ L+Q + D
Sbjct: 2227 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2286
Query: 380 ------------KESLKKA-----IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-- 420
KE ++ ++A+ E ++ +E A++ +L + +A+ L+
Sbjct: 2287 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2346
Query: 421 ------TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSL 471
TLE+ R R ++ E L+L RV ++ Q EE + R+ + +
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKL-------RVAEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 472 VERLHR---QTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYK 528
E+LHR T E E + ++L +A E+++ K ++ E + K
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLK 2458
Query: 529 SQVMKT----RLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ--FQSQLADLQQLPD 582
S+ M+T +L + A Q +++ +L+ E E E A+ + FQ ++A QQL +
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518
Query: 583 ILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKG 625
E Q Q Q E++ L A + + R R + ++G
Sbjct: 2519 ----------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/363 (22%), Positives = 158/363 (43%), Gaps = 31/363 (8%)
Query: 51 DTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDS 110
D N +R ++ + + E S RL L+ ED + K+
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2303
Query: 111 LMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEE 170
+ LK+E ++ + ++++A+ +E+ E++A +LAE E +
Sbjct: 2304 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE------------ETQGFQ 2351
Query: 171 KDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL 230
+ +++ L+ E KL AEM A A + A + + +++ T++
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--A 2409
Query: 231 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 290
T++K L+Q L + + + LRE + + E+ QQ A L +L + + +
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2469
Query: 291 LLQDKD-------KEVEELLQE---IQCEKAQAKT--ASELSKSMESMRGHLQAQLRSKE 338
LLQ+ E + LLQ I+ EKA+ + E++K+ + +R Q Q + E
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQME 2528
Query: 339 AENSRLCMQIKNLERSGNQHKAE--VEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 396
E RL ++ R QH+AE V E+L++L+Q+ + +E L + + +E+ +
Sbjct: 2529 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2586
Query: 397 SEE 399
EE
Sbjct: 2587 LEE 2589
Score = 57.8 bits (138), Expect = 3e-08
Identities = 102/525 (19%), Positives = 222/525 (42%), Gaps = 70/525 (13%)
Query: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 169
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1045 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1104
Query: 170 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 210
E L+K Q E + + E+ GA +V +
Sbjct: 1105 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1164
Query: 211 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 270
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1218
Query: 271 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 330
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1219 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268
Query: 331 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 378
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328
Query: 379 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 437
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1329 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1382
Query: 438 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 490
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1383 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 491 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 550
++ E + A E+Q L+A + E + + + R + + + + + +
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 551 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ 595
E L + E EAAR + Q L L++L + E +L + +
Sbjct: 1502 E---LASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQAE 1542
Score = 56.6 bits (135), Expect = 7e-08
Identities = 90/464 (19%), Positives = 200/464 (43%), Gaps = 26/464 (5%)
Query: 122 VKMQKGERQM-AKRFLEERKEELEEVAHELAETE---HENTVLRHNIERMKEEKDFTILQ 177
++ + GER + +R+ E + LE LA+T+ E L + +E D
Sbjct: 1149 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1208
Query: 178 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTI---GKLKTEKQMTCTDINTLTRQK 234
+ ++ +E + + + +Q AL + I G+ E Q +
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268
Query: 235 ELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD 294
EL +L T++ + ++ + SE ++++ L +E + ++ + + +
Sbjct: 1269 EL---QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1325
Query: 295 KDKEVEE---LLQEIQCEKAQ--AKTASELSKSMESMRGHLQAQLRS-KEAENSRLCMQ- 347
+ +EE L ++ + E+ + A+ + L K + H QA+ ++ +EA+ + MQ
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1385
Query: 348 -IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV 406
+ E + + + +I E+L++L+Q + + ++ + A + + EE + +
Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445
Query: 407 QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE 466
QL + A L++ R+R + +K + E L +V D +++ E ++
Sbjct: 1446 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1505
Query: 467 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMID 525
+ E + A LE RL+A A E +L QA +E +Q++ +++ +
Sbjct: 1506 RVKAEAEAAREKQRALQA--LEELRLQAEEA--ERRLRQAEVERARQVQVALETAQ---R 1558
Query: 526 NYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQ 569
+ ++++ R E AQLER +E + ++ +E E +Q
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,895,166
Number of Sequences: 37866
Number of extensions: 895961
Number of successful extensions: 13581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 408
Number of HSP's successfully gapped in prelim test: 1020
Number of HSP's that attempted gapping in prelim test: 5335
Number of HSP's gapped (non-prelim): 4704
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.