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Search of human proteins with 226246581
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
(639 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 1332 0.0
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 1315 0.0
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 1275 0.0
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 1153 0.0
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 1017 0.0
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 573 e-163
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 570 e-162
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 520 e-147
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 463 e-130
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 437 e-122
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 437 e-122
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 433 e-121
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 421 e-118
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 421 e-118
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 421 e-118
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 77 6e-14
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 70 6e-12
gi|122937514 unc-13 homolog C [Homo sapiens] 69 1e-11
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 69 1e-11
gi|122937247 unc-13 homolog A [Homo sapiens] 69 1e-11
gi|5031689 protein kinase D3 [Homo sapiens] 67 7e-11
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 66 9e-11
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 65 1e-10
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 65 1e-10
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 65 1e-10
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 65 2e-10
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 64 4e-10
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 64 4e-10
gi|5453976 protein kinase C, theta [Homo sapiens] 63 7e-10
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 63 9e-10
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 1332 bits (3448), Expect = 0.0
Identities = 639/639 (100%), Positives = 639/639 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKF 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKF
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKF 240
Query: 241 IHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYA 300
IHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYA
Sbjct: 241 IHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYA 300
Query: 301 RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG 360
RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG
Sbjct: 301 RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG 360
Query: 361 QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV 420
QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV
Sbjct: 361 QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV 420
Query: 421 TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG 480
TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG
Sbjct: 421 TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG 480
Query: 481 SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC 540
SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC
Sbjct: 481 SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC 540
Query: 541 GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG 600
GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG
Sbjct: 541 GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG 600
Query: 601 CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 639
CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 601 CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 639
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 1315 bits (3403), Expect = 0.0
Identities = 639/673 (94%), Positives = 639/673 (94%), Gaps = 34/673 (5%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 222 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 266
VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 267 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 326
AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
Sbjct: 301 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 360
Query: 327 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 386
LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
Sbjct: 361 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 420
Query: 387 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 446
EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
Sbjct: 421 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 480
Query: 447 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 506
EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
Sbjct: 481 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 540
Query: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 566
HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
Sbjct: 541 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 600
Query: 567 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 626
GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
Sbjct: 601 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 660
Query: 627 MDPPSTASSKLDS 639
MDPPSTASSKLDS
Sbjct: 661 MDPPSTASSKLDS 673
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 1275 bits (3300), Expect = 0.0
Identities = 625/673 (92%), Positives = 625/673 (92%), Gaps = 48/673 (7%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 221
PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
Query: 222 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 266
VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
Query: 267 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 326
AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
Sbjct: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
Query: 327 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 386
LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
Sbjct: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
Query: 387 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 446
EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
Sbjct: 407 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP 466
Query: 447 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 506
EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
Sbjct: 467 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL 526
Query: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 566
HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
Sbjct: 527 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 586
Query: 567 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 626
GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
Sbjct: 587 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV 646
Query: 627 MDPPSTASSKLDS 639
MDPPSTASSKLDS
Sbjct: 647 MDPPSTASSKLDS 659
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 1153 bits (2983), Expect = 0.0
Identities = 567/639 (88%), Positives = 570/639 (89%), Gaps = 63/639 (9%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKF 240
PMSSPGLGKKRKVSLLFDHLETGEL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGEL----------------------------------- 205
Query: 241 IHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYA 300
AQ L L+ F + A+T ALLELTELLASHNNYA
Sbjct: 206 ---AQHLTYLE-FRSFQAIT------------------------ALLELTELLASHNNYA 237
Query: 301 RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG 360
RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG
Sbjct: 238 RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG 297
Query: 361 QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV 420
QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV
Sbjct: 298 QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV 357
Query: 421 TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG 480
TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG
Sbjct: 358 TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG 417
Query: 481 SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC 540
SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC
Sbjct: 418 SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC 477
Query: 541 GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG 600
GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG
Sbjct: 478 GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG 537
Query: 601 CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 639
CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 538 CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 1017 bits (2629), Expect = 0.0
Identities = 517/641 (80%), Positives = 535/641 (83%), Gaps = 39/641 (6%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKF 240
PMSSPGLGKKRKVSLLFDHLETGELAQ +L + F++ + P L R+ VL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQ---HLTYLEFRSFQAIT---PQDL-RSYVLQGS 233
Query: 241 IHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELL--ASHNN 298
+ L + GL +S +SR P + L + + A +
Sbjct: 234 VRGCPALEG----------SVGLSNS-VSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLH 282
Query: 299 YARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVAL 358
+ T G L + RL D HL + +ELVAL
Sbjct: 283 QLQNFNTLMAVTG--------------GLCHSAISRLKDSHAHLSPDST-----KELVAL 323
Query: 359 QGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAP 418
QGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAP
Sbjct: 324 QGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAP 383
Query: 419 GVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQG 478
GVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQG
Sbjct: 384 GVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQG 443
Query: 479 RGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 538
RGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR
Sbjct: 444 RGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 503
Query: 539 ECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPE 598
ECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPE
Sbjct: 504 ECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPE 563
Query: 599 TGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 639
TGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 564 TGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 604
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 375 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 434
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
Query: 435 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 494
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
Query: 495 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 554
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
Query: 555 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 614
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
Query: 615 PSWETDTVPCPVMDPPSTASSKLDS 639
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
Score = 454 bits (1169), Expect = e-128
Identities = 221/222 (99%), Positives = 222/222 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITV 222
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT+
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITL 222
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 570 bits (1470), Expect = e-162
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 377 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 436
LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
Query: 437 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 496
VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
Query: 497 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 556
ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
Query: 557 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 616
KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558
Query: 617 WETDTVPCPVMDPPSTASSKLDS 639
WETDTVPCPVMDPPSTASSKLDS
Sbjct: 559 WETDTVPCPVMDPPSTASSKLDS 581
Score = 565 bits (1455), Expect = e-161
Identities = 292/340 (85%), Positives = 294/340 (86%), Gaps = 36/340 (10%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT------------------- 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 222 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 266
VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 267 AISRLKDSHAHLSPDSTKALLEL--TELLASHNNYARYRR 304
AISRLKDSHAHLSPDSTK L+L TE +YAR R
Sbjct: 301 AISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPR 340
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 520 bits (1340), Expect = e-147
Identities = 273/569 (47%), Positives = 367/569 (64%), Gaps = 40/569 (7%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAIT----------------------------------VMVLSRPGPLQRAQVLDK 239
F+SF+ I+ +MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 240 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 299
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L E+TELL+S NY
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337
Query: 300 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 359
YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL LY + ELV LQ
Sbjct: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397
Query: 360 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 419
PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P P+VV+WA G
Sbjct: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASG 457
Query: 420 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 479
V+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+ + +
Sbjct: 458 VSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 514
Query: 480 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 539
G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 515 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 574
Query: 540 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 568
CG+ CHK C+D V ECKKR AK P
Sbjct: 575 CGMNCHKQCKDLVVFECKKR--AKNPVAP 601
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 463 bits (1191), Expect = e-130
Identities = 256/569 (44%), Positives = 338/569 (59%), Gaps = 75/569 (13%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAIT----------------------------------VMVLSRPGPLQRAQVLDK 239
F+SF+ I+ +MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 240 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNY 299
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L E+TELL+S NY
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNY 337
Query: 300 ARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQ 359
YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL LY + ELV LQ
Sbjct: 338 DNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQ 397
Query: 360 GQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPG 419
PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR
Sbjct: 398 EVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR--------------------- 436
Query: 420 VTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGR 479
SVFKNYD + G ISQE+FE+++ +FPF+ + +
Sbjct: 437 --------------NHRAPSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM---DKDRE 479
Query: 480 GSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRE 539
G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQGYRC++
Sbjct: 480 GLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKD 539
Query: 540 CGLCCHKHCRDQVKVECKKRPGAKGDAGP 568
CG+ CHK C+D V ECKKR AK P
Sbjct: 540 CGMNCHKQCKDLVVFECKKR--AKNPVAP 566
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 437 bits (1124), Expect = e-122
Identities = 241/556 (43%), Positives = 338/556 (60%), Gaps = 46/556 (8%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT----------------- 221
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 222 -----------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 264
+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 265 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 324
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
Query: 325 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 384
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
Query: 385 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 441
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 370 EDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 429
Query: 442 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 500
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 430 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 488
Query: 501 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 560
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 489 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 548
Query: 561 GA----KGDAGPPGAP 572
A G PG+P
Sbjct: 549 RAPSLSSGHGSLPGSP 564
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 437 bits (1124), Expect = e-122
Identities = 241/556 (43%), Positives = 338/556 (60%), Gaps = 46/556 (8%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT----------------- 221
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 222 -----------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 264
+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 265 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 324
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
Query: 325 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 384
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
Query: 385 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 441
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 370 EDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 429
Query: 442 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 500
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 430 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 488
Query: 501 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 560
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 489 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 548
Query: 561 GA----KGDAGPPGAP 572
A G PG+P
Sbjct: 549 RAPSLSSGHGSLPGSP 564
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 433 bits (1114), Expect = e-121
Identities = 241/556 (43%), Positives = 338/556 (60%), Gaps = 47/556 (8%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT----------------- 221
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 222 -----------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 264
+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 265 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 324
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
Query: 325 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 384
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
Query: 385 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 441
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 370 EDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 428
Query: 442 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 500
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 429 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 487
Query: 501 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 560
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 488 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 547
Query: 561 GA----KGDAGPPGAP 572
A G PG+P
Sbjct: 548 RAPSLSSGHGSLPGSP 563
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 421 bits (1083), Expect = e-118
Identities = 236/562 (41%), Positives = 325/562 (57%), Gaps = 47/562 (8%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF----------------- 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 218 -----------------QAITVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 260
Q + +M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 261 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 320
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
Query: 321 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 378
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
Query: 379 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 432
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
Query: 433 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 492
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
Query: 493 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 552
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
Query: 553 KVECKKRPGAKGDAGPPGAPVP 574
VEC++R + G +P P
Sbjct: 545 SVECRRRAQSVSLEGSAPSPSP 566
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 421 bits (1083), Expect = e-118
Identities = 236/562 (41%), Positives = 325/562 (57%), Gaps = 47/562 (8%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF----------------- 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 218 -----------------QAITVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 260
Q + +M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 261 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 320
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
Query: 321 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 378
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
Query: 379 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 432
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
Query: 433 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 492
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
Query: 493 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 552
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
Query: 553 KVECKKRPGAKGDAGPPGAPVP 574
VEC++R + G +P P
Sbjct: 545 SVECRRRAQSVSLEGSAPSPSP 566
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 421 bits (1083), Expect = e-118
Identities = 236/562 (41%), Positives = 325/562 (57%), Gaps = 47/562 (8%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF----------------- 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 218 -----------------QAITVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 260
Q + +M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 261 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 320
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
Query: 321 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 378
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
Query: 379 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 432
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
Query: 433 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 492
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
Query: 493 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 552
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
Query: 553 KVECKKRPGAKGDAGPPGAPVP 574
VEC++R + G +P P
Sbjct: 545 SVECRRRAQSVSLEGSAPSPSP 566
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 76.6 bits (187), Expect = 6e-14
Identities = 53/169 (31%), Positives = 84/169 (49%), Gaps = 3/169 (1%)
Query: 233 RAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLE-LTE 291
RA ++K++ VA L N+N ++ +T L SAI RLK + A +S TKAL++ L +
Sbjct: 1070 RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQ-TKALMDKLQK 1128
Query: 292 LLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLR 351
++S + R T C +P LG++L DL + E P+ +G ++ K+ +
Sbjct: 1129 TVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHI 1188
Query: 352 LQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCP 400
++E+ Q + L L DL ED +YELS EPR P
Sbjct: 1189 IREIRQFQQTSYRIDHQPKVAQYL-LDKDLIIDEDTLYELSLKIEPRLP 1236
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 70.1 bits (170), Expect = 6e-12
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 479 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 536
R S EEL ++ + + A+ + H F T PT+C C G LWG+ +QG R
Sbjct: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
Query: 537 CRECGLCCHKHCRDQVKVECKKRPGAK 563
C ECG+ CH+ C+D + +C +R K
Sbjct: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 69.3 bits (168), Expect = 1e-11
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 479 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 536
R S + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG +
Sbjct: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
Query: 537 CRECGLCCHKHCRDQVKVECKKRPGAK 563
C ECG+ CH+ C+D + +C +R K
Sbjct: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 69.3 bits (168), Expect = 1e-11
Identities = 51/176 (28%), Positives = 81/176 (46%), Gaps = 16/176 (9%)
Query: 232 QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTE 291
QRAQV++ FI VA+ + NFN+LMA+ G+ S +SRLK + A + T L
Sbjct: 274 QRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV---RTAKFFILEH 330
Query: 292 LLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLHEAQPDRLPDGRL 340
+ N+ YR G A L P + +KD+ L+E +RLP+G +
Sbjct: 331 QMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHV 390
Query: 341 HLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYARE 396
+ K L ++ E + + P + + H L + ++ED +Y SY E
Sbjct: 391 NFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSEDGLYLASYESE 444
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 68.9 bits (167), Expect = 1e-11
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 481 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 538
+ + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG RC
Sbjct: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
Query: 539 ECGLCCHKHCRDQVKVECKKRPGAK 563
ECG+ CH+ C+D + +C +R K
Sbjct: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 66.6 bits (161), Expect = 7e-11
Identities = 43/131 (32%), Positives = 60/131 (45%), Gaps = 14/131 (10%)
Query: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC---KKRPGAK 563
HT + +++ PTFCD C LWG+ +QG +C CGL HK C ++ C +KR +
Sbjct: 155 HTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSN 214
Query: 564 GDAGPPGAPVPSTPAP-HASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTV 622
PG VP P + + SEE+H + EP +W S P W V
Sbjct: 215 VSLPGPGLSVPRPLQPEYVALPSEESHVHQ---EPSKRIP---SW----SGRPIWMEKMV 264
Query: 623 PCPVMDPPSTA 633
C V P + A
Sbjct: 265 MCRVKVPHTFA 275
Score = 51.2 bits (121), Expect = 3e-06
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 556
HTF ++ +PT C C L G+ +QG +C++C CHK C +V +C
Sbjct: 272 HTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDC 321
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 66.2 bits (160), Expect = 9e-11
Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 20/152 (13%)
Query: 230 PLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLEL 289
P QRA++L+K+I VA+ L+NF+++ AV L S I RL+ + + DS + L
Sbjct: 325 PPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSL 384
Query: 290 TELLASHNNYARYRRTW----------------AGCAGFR----LPVLGVHLKDLVSLHE 329
++ + +NY++ R A +G R +P LG LKDLV L
Sbjct: 385 CQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDA 444
Query: 330 AQPDRLPDGRLHLPKLNNLYLRLQELVALQGQ 361
A D L +G ++ K + L EL LQ +
Sbjct: 445 ASKDELENGYINFDKRRKEFAVLSELRRLQNE 476
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/169 (27%), Positives = 79/169 (46%), Gaps = 3/169 (1%)
Query: 233 RAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLE-LTE 291
R ++K++ VA L N+N ++ +T + SAI RLK + +S TKAL++ L +
Sbjct: 1090 RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQ-TKALIDKLQK 1148
Query: 292 LLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLR 351
L++S + R C +P LG++L DL + E P+ DG ++ K+ +
Sbjct: 1149 LVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHI 1208
Query: 352 LQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCP 400
++E+ Q + L L E+ +YE S EP+ P
Sbjct: 1209 IREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPKLP 1256
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/169 (27%), Positives = 79/169 (46%), Gaps = 3/169 (1%)
Query: 233 RAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLE-LTE 291
R ++K++ VA L N+N ++ +T + SAI RLK + +S TKAL++ L +
Sbjct: 1106 RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQ-TKALIDKLQK 1164
Query: 292 LLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLR 351
L++S + R C +P LG++L DL + E P+ DG ++ K+ +
Sbjct: 1165 LVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHI 1224
Query: 352 LQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCP 400
++E+ Q + L L E+ +YE S EP+ P
Sbjct: 1225 IREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPKLP 1272
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/169 (27%), Positives = 79/169 (46%), Gaps = 3/169 (1%)
Query: 233 RAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLE-LTE 291
R ++K++ VA L N+N ++ +T + SAI RLK + +S TKAL++ L +
Sbjct: 322 RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQ-TKALIDKLQK 380
Query: 292 LLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLR 351
L++S + R C +P LG++L DL + E P+ DG ++ K+ +
Sbjct: 381 LVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHI 440
Query: 352 LQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCP 400
++E+ Q + L L E+ +YE S EP+ P
Sbjct: 441 IREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPKLP 488
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/176 (28%), Positives = 85/176 (48%), Gaps = 18/176 (10%)
Query: 233 RAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTEL 292
RA++++ FI VA+ + NFN+LMA+ G+ S +SRLK + A + T L
Sbjct: 282 RARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV---KTAKFDILEHQ 338
Query: 293 LASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLHEAQPDRLPDGRLH 341
+ +N+ YR G A L P + +KD+ L+E +RLP+G ++
Sbjct: 339 MDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVN 398
Query: 342 LPKLNNLYLRLQELVALQGQHPPCSANEDLL-HLLTLSLDLFYTEDEIYELSYARE 396
K L ++ E + + P + +L +LLT+ + ++ED +Y SY E
Sbjct: 399 FEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---FSEDALYLASYESE 451
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 63.9 bits (154), Expect = 4e-10
Identities = 49/194 (25%), Positives = 91/194 (46%), Gaps = 8/194 (4%)
Query: 205 LAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 264
L Q + S+ ++++L R ++L KFI + + L +L NFN+ +A+ L
Sbjct: 897 LTQFTEHFNNMSYWVRSIIMLQEKAQ-DRERLLLKFIKIMKHLRKLNNFNSYLAILSALD 955
Query: 265 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 324
+ I RL+ +++ L E L+ S +++ YR + +P LG+ L+DL
Sbjct: 956 SAPIRRLE-----WQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDL 1010
Query: 325 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 384
+H PD + DG+++ K + L + Q H N+D+++ D
Sbjct: 1011 TFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLA 1068
Query: 385 EDEIYELSYAREPR 398
E+ ++ELS +PR
Sbjct: 1069 EEALWELSLKIKPR 1082
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 63.9 bits (154), Expect = 4e-10
Identities = 49/194 (25%), Positives = 91/194 (46%), Gaps = 8/194 (4%)
Query: 205 LAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 264
L Q + S+ ++++L R ++L KFI + + L +L NFN+ +A+ L
Sbjct: 879 LTQFTEHFNNMSYWVRSIIMLQEKAQ-DRERLLLKFIKIMKHLRKLNNFNSYLAILSALD 937
Query: 265 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 324
+ I RL+ +++ L E L+ S +++ YR + +P LG+ L+DL
Sbjct: 938 SAPIRRLE-----WQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDL 992
Query: 325 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 384
+H PD + DG+++ K + L + Q H N+D+++ D
Sbjct: 993 TFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLA 1050
Query: 385 EDEIYELSYAREPR 398
E+ ++ELS +PR
Sbjct: 1051 EEALWELSLKIKPR 1064
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 63.2 bits (152), Expect = 7e-10
Identities = 24/50 (48%), Positives = 31/50 (62%)
Query: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 556
H F F +PTFC C F+WG+ KQGY+CR+C HK C D+V +C
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209
Score = 53.5 bits (127), Expect = 6e-07
Identities = 19/50 (38%), Positives = 28/50 (56%)
Query: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 556
H F ++ PTFC+ C LWG+ +QG +C CG+ H C+ +V C
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 281
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 9e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 473 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 532
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 533 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 568
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 507 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 556
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,800,679
Number of Sequences: 37866
Number of extensions: 1644664
Number of successful extensions: 12216
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 10830
Number of HSP's gapped (non-prelim): 1445
length of query: 639
length of database: 18,247,518
effective HSP length: 109
effective length of query: 530
effective length of database: 14,120,124
effective search space: 7483665720
effective search space used: 7483665720
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.