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Search of human proteins with 11497040
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
(722 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 1538 0.0
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 940 0.0
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 782 0.0
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 782 0.0
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 782 0.0
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 782 0.0
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 542 e-154
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 525 e-149
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 354 1e-97
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 351 1e-96
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 349 4e-96
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 339 5e-93
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 337 3e-92
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 330 4e-90
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 314 2e-85
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 311 2e-84
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 299 5e-81
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 298 1e-80
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 285 1e-76
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 285 1e-76
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 285 1e-76
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 285 1e-76
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 285 1e-76
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 285 1e-76
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 277 2e-74
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 277 2e-74
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 277 2e-74
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 277 2e-74
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 277 2e-74
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 274 2e-73
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 1538 bits (3981), Expect = 0.0
Identities = 722/722 (100%), Positives = 722/722 (100%)
Query: 1 MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGW 60
MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGW
Sbjct: 1 MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGW 60
Query: 61 LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE 120
LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE
Sbjct: 61 LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE 120
Query: 121 SLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEV 180
SLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEV
Sbjct: 121 SLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEV 180
Query: 181 ARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVN 240
ARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVN
Sbjct: 181 ARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVN 240
Query: 241 IVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIK 300
IVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIK
Sbjct: 241 IVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIK 300
Query: 301 NSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGE 360
NSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGE
Sbjct: 301 NSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGE 360
Query: 361 RGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQC 420
RGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQC
Sbjct: 361 RGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQC 420
Query: 421 DCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGT 480
DCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGT
Sbjct: 421 DCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGT 480
Query: 481 SHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRF 540
SHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRF
Sbjct: 481 SHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRF 540
Query: 541 GHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMN 600
GHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMN
Sbjct: 541 GHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMN 600
Query: 601 ISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPP 660
ISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPP
Sbjct: 601 ISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPP 660
Query: 661 YCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHS 720
YCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHS
Sbjct: 661 YCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHS 720
Query: 721 SG 722
SG
Sbjct: 721 SG 722
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 940 bits (2429), Expect = 0.0
Identities = 444/721 (61%), Positives = 545/721 (75%), Gaps = 4/721 (0%)
Query: 1 MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGW 60
MAV LV+IRVTLLLLW G+FLSISG+ QA PSQ+FTSPEVVIPLKVISRGR AKAPGW
Sbjct: 51 MAVGEPLVHIRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGW 110
Query: 61 LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE 120
LSYSLRFGGQ+++VHMRV KLL + HLPVFTYT++ ALL+DQ FI DDCYYHGYVEG PE
Sbjct: 111 LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPE 170
Query: 121 SLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEV 180
SLV S C GGF G+L+I+ L YEI+PI SATFEHLVYK++S++TQFP MRCGLTE+++
Sbjct: 171 SLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKI 230
Query: 181 ARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVN 240
A Q +E + + N L+ S WWTH F+ELVVVV++ +++SQSN + VQ +VF VVN
Sbjct: 231 AHQ-MELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVN 289
Query: 241 IVDSMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQISLS-QLQHDAAHMF 298
IVDS Y L +IL GI+IW N P + ++ VL DFS WK +L+ +LQHD AH+F
Sbjct: 290 IVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLF 349
Query: 299 IKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFC 358
IK++ LG+AYV GIC+ P + GVD F+ + +FA T+ HELGH LGMQHD ++C C
Sbjct: 350 IKDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVC 409
Query: 359 GERGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREE 418
+ CIM+ +R KF+NCSYA + +T++ G C+ PP G IF LK CGN VVE E
Sbjct: 410 ELQWCIMHAYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGE 469
Query: 419 QCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCN 478
+CDCG+++QC +D CCLLNCTL PGAACAFG+CCKDCKF+PSG LCRQ+V ECDLPEWCN
Sbjct: 470 ECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCN 529
Query: 479 GTSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGN 538
GTSHQCP+D YVQDGI C+ +A+CY+K CNNHD C+EIFG+DA+SASQ+CY+EIN+QGN
Sbjct: 530 GTSHQCPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGN 589
Query: 539 RFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLR 598
RFGHCGI GTTY+KC D+ CGRVQCENV IP L +H T+Q H+N TCWG DYHL
Sbjct: 590 RFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLG 649
Query: 599 MNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWS 658
M I DIGEVKDGTVCGP KICI KKC S+ LS C P+TCNM+GICNNK HCHC + W+
Sbjct: 650 MAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWA 709
Query: 659 PPYCQHRGYGGSIDSGPASAKRGVFLPLI-VIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
PPYC+ +GYGGS DSGP L ++ + LS+L L V L++ K TK
Sbjct: 710 PPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTK 769
Query: 718 A 718
+
Sbjct: 770 S 770
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 782 bits (2019), Expect = 0.0
Identities = 357/711 (50%), Positives = 481/711 (67%), Gaps = 9/711 (1%)
Query: 10 IRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGG 69
+++ LLL LGVFLS SG+ Q Q+ + P+VVIP+++ R PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 70 QKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACF 129
QKH++H++VKKLL S+HLPVFTYTD+ A+LEDQ F+ ++CYYHGYVEG PESLV S CF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 130 GGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEE 189
GGF+G+L+I+ YEI+P+ S TFEHLVYK++S E QF MR G + E+ + +EFEE
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCR-MEFEE 179
Query: 190 AENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
+NS + S WW H +E+VVV+++ +I + N SK+ ED++++VNIVDS+ +
Sbjct: 180 IDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVI 239
Query: 250 GTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISILG 308
G ++L G+EIW N+ + + + ++ + +WK +++ ++QHD +H+F L + G
Sbjct: 240 GVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSG 299
Query: 309 LAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTF 368
+ G+C P C + F T F+ VAH LGH LGM HDE+ C C + CIM+
Sbjct: 300 IGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEG 359
Query: 369 RVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428
P KF+NCSY DF + T+ + CL +IF +KRCGNGVVE E+CDCG ++ C
Sbjct: 360 NPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHC 419
Query: 429 EQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDR 488
+D CCL NCTL G+ CAFGLCCKDCKF+PSG++CR+EVNECDLPEWCNGTSH+CP+D
Sbjct: 420 AKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDF 479
Query: 489 YVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT 548
YV+DGIPC + YCY+K C++ ++ CR IFG A +AS+ CYKE+N+ G+R GHCGI
Sbjct: 480 YVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNA 539
Query: 549 TYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVK 608
TY+KC+ISDV CGR+QCENV +IP + DH T+ N + CW DYHL M DIGEVK
Sbjct: 540 TYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVK 599
Query: 609 DGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYG 668
DGT CG ICIH+ CV +++L+ C P CN +GICNNKHHCHC Y W PP C +GYG
Sbjct: 600 DGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYG 659
Query: 669 GSIDSG--PASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
GS+DSG P K+ F L ++ +L LF + +Y R C K K
Sbjct: 660 GSVDSGPPPKRKKKKKFCYLCIL----LLIVLFILLCCLY-RLCKKSKPIK 705
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 782 bits (2019), Expect = 0.0
Identities = 357/711 (50%), Positives = 481/711 (67%), Gaps = 9/711 (1%)
Query: 10 IRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGG 69
+++ LLL LGVFLS SG+ Q Q+ + P+VVIP+++ R PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 70 QKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACF 129
QKH++H++VKKLL S+HLPVFTYTD+ A+LEDQ F+ ++CYYHGYVEG PESLV S CF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 130 GGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEE 189
GGF+G+L+I+ YEI+P+ S TFEHLVYK++S E QF MR G + E+ + +EFEE
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCR-MEFEE 179
Query: 190 AENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
+NS + S WW H +E+VVV+++ +I + N SK+ ED++++VNIVDS+ +
Sbjct: 180 IDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVI 239
Query: 250 GTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISILG 308
G ++L G+EIW N+ + + + ++ + +WK +++ ++QHD +H+F L + G
Sbjct: 240 GVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSG 299
Query: 309 LAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTF 368
+ G+C P C + F T F+ VAH LGH LGM HDE+ C C + CIM+
Sbjct: 300 IGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEG 359
Query: 369 RVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428
P KF+NCSY DF + T+ + CL +IF +KRCGNGVVE E+CDCG ++ C
Sbjct: 360 NPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHC 419
Query: 429 EQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDR 488
+D CCL NCTL G+ CAFGLCCKDCKF+PSG++CR+EVNECDLPEWCNGTSH+CP+D
Sbjct: 420 AKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDF 479
Query: 489 YVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT 548
YV+DGIPC + YCY+K C++ ++ CR IFG A +AS+ CYKE+N+ G+R GHCGI
Sbjct: 480 YVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNA 539
Query: 549 TYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVK 608
TY+KC+ISDV CGR+QCENV +IP + DH T+ N + CW DYHL M DIGEVK
Sbjct: 540 TYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVK 599
Query: 609 DGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYG 668
DGT CG ICIH+ CV +++L+ C P CN +GICNNKHHCHC Y W PP C +GYG
Sbjct: 600 DGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYG 659
Query: 669 GSIDSG--PASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
GS+DSG P K+ F L ++ +L LF + +Y R C K K
Sbjct: 660 GSVDSGPPPKRKKKKKFCYLCIL----LLIVLFILLCCLY-RLCKKSKPIK 705
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 782 bits (2019), Expect = 0.0
Identities = 357/711 (50%), Positives = 481/711 (67%), Gaps = 9/711 (1%)
Query: 10 IRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGG 69
+++ LLL LGVFLS SG+ Q Q+ + P+VVIP+++ R PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 70 QKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACF 129
QKH++H++VKKLL S+HLPVFTYTD+ A+LEDQ F+ ++CYYHGYVEG PESLV S CF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 130 GGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEE 189
GGF+G+L+I+ YEI+P+ S TFEHLVYK++S E QF MR G + E+ + +EFEE
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCR-MEFEE 179
Query: 190 AENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
+NS + S WW H +E+VVV+++ +I + N SK+ ED++++VNIVDS+ +
Sbjct: 180 IDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVI 239
Query: 250 GTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISILG 308
G ++L G+EIW N+ + + + ++ + +WK +++ ++QHD +H+F L + G
Sbjct: 240 GVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSG 299
Query: 309 LAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTF 368
+ G+C P C + F T F+ VAH LGH LGM HDE+ C C + CIM+
Sbjct: 300 IGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEG 359
Query: 369 RVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428
P KF+NCSY DF + T+ + CL +IF +KRCGNGVVE E+CDCG ++ C
Sbjct: 360 NPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHC 419
Query: 429 EQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDR 488
+D CCL NCTL G+ CAFGLCCKDCKF+PSG++CR+EVNECDLPEWCNGTSH+CP+D
Sbjct: 420 AKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDF 479
Query: 489 YVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT 548
YV+DGIPC + YCY+K C++ ++ CR IFG A +AS+ CYKE+N+ G+R GHCGI
Sbjct: 480 YVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNA 539
Query: 549 TYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVK 608
TY+KC+ISDV CGR+QCENV +IP + DH T+ N + CW DYHL M DIGEVK
Sbjct: 540 TYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVK 599
Query: 609 DGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYG 668
DGT CG ICIH+ CV +++L+ C P CN +GICNNKHHCHC Y W PP C +GYG
Sbjct: 600 DGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYG 659
Query: 669 GSIDSG--PASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
GS+DSG P K+ F L ++ +L LF + +Y R C K K
Sbjct: 660 GSVDSGPPPKRKKKKKFCYLCIL----LLIVLFILLCCLY-RLCKKSKPIK 705
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 782 bits (2019), Expect = 0.0
Identities = 357/711 (50%), Positives = 481/711 (67%), Gaps = 9/711 (1%)
Query: 10 IRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGG 69
+++ LLL LGVFLS SG+ Q Q+ + P+VVIP+++ R PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 70 QKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACF 129
QKH++H++VKKLL S+HLPVFTYTD+ A+LEDQ F+ ++CYYHGYVEG PESLV S CF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 130 GGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEE 189
GGF+G+L+I+ YEI+P+ S TFEHLVYK++S E QF MR G + E+ + +EFEE
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCR-MEFEE 179
Query: 190 AENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
+NS + S WW H +E+VVV+++ +I + N SK+ ED++++VNIVDS+ +
Sbjct: 180 IDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVI 239
Query: 250 GTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISILG 308
G ++L G+EIW N+ + + + ++ + +WK +++ ++QHD +H+F L + G
Sbjct: 240 GVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSG 299
Query: 309 LAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTF 368
+ G+C P C + F T F+ VAH LGH LGM HDE+ C C + CIM+
Sbjct: 300 IGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEG 359
Query: 369 RVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428
P KF+NCSY DF + T+ + CL +IF +KRCGNGVVE E+CDCG ++ C
Sbjct: 360 NPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHC 419
Query: 429 EQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDR 488
+D CCL NCTL G+ CAFGLCCKDCKF+PSG++CR+EVNECDLPEWCNGTSH+CP+D
Sbjct: 420 AKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDF 479
Query: 489 YVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT 548
YV+DGIPC + YCY+K C++ ++ CR IFG A +AS+ CYKE+N+ G+R GHCGI
Sbjct: 480 YVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNA 539
Query: 549 TYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVK 608
TY+KC+ISDV CGR+QCENV +IP + DH T+ N + CW DYHL M DIGEVK
Sbjct: 540 TYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVK 599
Query: 609 DGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYG 668
DGT CG ICIH+ CV +++L+ C P CN +GICNNKHHCHC Y W PP C +GYG
Sbjct: 600 DGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYG 659
Query: 669 GSIDSG--PASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
GS+DSG P K+ F L ++ +L LF + +Y R C K K
Sbjct: 660 GSVDSGPPPKRKKKKKFCYLCIL----LLIVLFILLCCLY-RLCKKSKPIK 705
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 542 bits (1397), Expect = e-154
Identities = 292/730 (40%), Positives = 411/730 (56%), Gaps = 42/730 (5%)
Query: 11 RVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQ 70
R+ LLL+ + S+ P F S EV IP K+ RG +SY L+ G+
Sbjct: 12 RLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGK 71
Query: 71 KHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFG 130
KHV+H+ K+LL+ RHL VF++T+ LLED +IP DC Y G V+ + +S S C G
Sbjct: 72 KHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMG 131
Query: 131 GFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEA 190
G RGV I Y+IEP++ S +FEH+VY + QF CGL++ E+ Q +E
Sbjct: 132 GLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYENK 189
Query: 191 ENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQLG 250
P S + H +LEL+++ + + + +N+S+V D L+ I+D+ +Q +
Sbjct: 190 ARLRDFPGS----YKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245
Query: 251 TYIILIGIEIWNQGNVFPM--TSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISIL 307
I L +E+W N + + +VL F +K+ L+ +L D AH++++ L
Sbjct: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305
Query: 308 GLAY-------VAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFC-G 359
++ AG +D + TWS AHELGH +GM HDE++C C G
Sbjct: 306 AWSFGKVCSLEYAGSVSTLLDTNI--LAPATWS------AHELGHAVGMSHDEQYCQCRG 357
Query: 360 ERGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQ 419
CIM + R F+NCSY F K + +CL+N P LG ++LKRCGN +VE E+
Sbjct: 358 RLNCIMGSGRTG---FSNCSYISFFKHISSGATCLNNIPGLG--YVLKRCGNKIVEDNEE 412
Query: 420 CDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNG 479
CDCGS ++C++D CC NC L+PGA C+ GLCC DC+F PSG +CRQE NECDL E+C+G
Sbjct: 413 CDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDG 472
Query: 480 TSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNR 539
S CP D Y QDG PC C++K C + C+ IFG DA A CY +N G++
Sbjct: 473 NSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQ 532
Query: 540 FGHCGING-TTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHI--NGVTCWGIDYH 596
FG+C I G + KC ++ CGR+QC NV IP L +H T+ TH+ + CWG YH
Sbjct: 533 FGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYH 592
Query: 597 LR---MNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHC 653
L M I D+G + DGT CG G++C K CV+ SVL CLPE CN +G+CNN+ +CHC
Sbjct: 593 LSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHC 652
Query: 654 GYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSV--LTFLFTVGLLMYLRQCS 711
YGW+PP+C+ GYGGSIDSGP RG I + S+ + L L + ++ RQ
Sbjct: 653 MYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVI 712
Query: 712 G----PKETK 717
G PK+ K
Sbjct: 713 GNHLKPKQEK 722
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 525 bits (1353), Expect = e-149
Identities = 266/710 (37%), Positives = 420/710 (59%), Gaps = 24/710 (3%)
Query: 10 IRVTLLLLWLGVFLSISGYCQAGPSQ--HFTSPEVVIPLKVISRGRSAKAP--GWLSYSL 65
+RV LLL LG+ + G + G Q H +S E++ P ++ R A P +SY +
Sbjct: 12 LRVRWLLL-LGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVI 70
Query: 66 RFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVF 125
+ G++H++H+ K L+ V+TY E L+ D I + C+Y GYVEG S +
Sbjct: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130
Query: 126 SACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQL 185
S CFG RG+L + +Y IEP+++S+ FEH++Y+++ + ++CG++ K++ ++
Sbjct: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMD--DVYKEPLKCGVSNKDIEKETA 187
Query: 186 EFEEAENSALEP--KSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVD 243
+ EE E ++ + ++EL +VV+ + + N + V+E++ L+ N +D
Sbjct: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
Query: 244 SMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQ-ISLSQLQHDAAHMFIKN 301
SMY L I+L+G+EIW GN+ + VL +F QW++ +++ +HD+A + +K
Sbjct: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
Query: 302 SLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDE-EFCFCGE 360
G+A+V +C G++ F T FA+ VAHELGH LGM HD+ C CG
Sbjct: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367
Query: 361 RGCIMNTFRVPAEKFTNCSYADFMKTTLNQG-SCLHNPPRLGEIFMLKRCGNGVVEREEQ 419
+ CIMN+ + F++CS DF K TLN+G +CL N P+ E + CGN +V+ E+
Sbjct: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
Query: 420 CDCGSVQQCEQDACCL-LNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCN 478
CDCG+ ++CE D CC C L+ A CA+G CCKDC+F+P G LCR + +ECD+PE+CN
Sbjct: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487
Query: 479 GTSHQCPEDRYVQDGIPCSDS-AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQG 537
G+S C D ++Q+G PC ++ AYCY C +D C+ IFG AK+A ++C+ E+NS+G
Sbjct: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
Query: 538 NRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHL 597
+RFG+CG +G Y KC + CG++QCENV++IP+ + T G CWG+D+ L
Sbjct: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607
Query: 598 RMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVC-LPETCNMKGICNNKHHCHCGYG 656
++ D G V +GT CG GKIC + +CV SVL++ C + + C+ G+CN+ +CHC G
Sbjct: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667
Query: 657 WSPPYCQHRGYGGSIDSGPASAKRGVFLP-------LIVIPSLSVLTFLF 699
W+PP C+ +GYGGS+DSGP + L +++P + F+F
Sbjct: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIF 717
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 354 bits (909), Expect = 1e-97
Identities = 230/731 (31%), Positives = 364/731 (49%), Gaps = 70/731 (9%)
Query: 20 GVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVK 79
GV L G S S ++ IP+K S P L+ L+ ++ ++++
Sbjct: 30 GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
Query: 80 KLLVSRHLPVFTYTDER---ALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGGFRGVL 136
+ L++ Y + +L + I CYYHG+V G +S V S C G RG++
Sbjct: 87 EGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLI 145
Query: 137 KISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAENSALE 196
+Y +EP++ SAT YK+ FPA + A +
Sbjct: 146 VFENESYVLEPMK-SATNR---YKL------FPAKKLKSVRGSCGSHHNTPNLAAKNVFP 195
Query: 197 PKSAGDWWTH-------AWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
P S H ++ELV+V ++ F ++ KV++ + + N VD Y+ L
Sbjct: 196 PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPL 255
Query: 250 GTYIILIGIEIWNQGNVF-----PMTSIEQVLNDFSQWKQISL-SQLQHDAAHM----FI 299
I+L+G+E+WN + P TS L++F W+++ L + HD A + +
Sbjct: 256 NIRIVLVGVEVWNDMDKCSVSQDPFTS----LHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
Query: 300 KNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD--EEFCF 357
+ + I G+A + +C G+ D A T+AHELGH GM HD + C
Sbjct: 312 QGTTI---GMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
Query: 358 CG----ERGCIMNT---FRVPAEKFTNCSYADFMKTTLNQGS--CLHNPPRLGEIFMLKR 408
C + GCIMN + P F++CS D ++T+L +G CL N P + E F ++
Sbjct: 369 CQMAVEKGGCIMNASTGYPFPMV-FSSCSRKD-LETSLEKGMGVCLFNLPEVRESFGGQK 426
Query: 409 CGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEV 468
CGN VE E+CDCG ++C C CTL+P A CA GLCC+DC+ P+G CR
Sbjct: 427 CGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
Query: 469 NECDLPEWCNGTSHQCPEDRYVQDGIPCSD-SAYCYQKRCNNHDQHCREIFGKDAKSASQ 527
N CDLPE+C G S CP + Y+ DG C D YCY C H+Q C ++G AK A
Sbjct: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
Query: 528 NCYKEINSQGNRFGHCG-INGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHI- 585
C++ +NS G+ +G+CG ++ +++ KC + D CG++QC+ P++ + T+I
Sbjct: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
Query: 586 ----NGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLS-HVCLPETCN 640
+ C G +L ++ D G V GT C GKIC++++C ++SV H C + C+
Sbjct: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ-CH 665
Query: 641 MKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGP--ASAKRGVFLPLIVIPSLSVLTFL 698
+G+CNN+ +CHC W+PP+C G+GGS DSGP + +G+ + ++V + L
Sbjct: 666 GRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILV-----TILCL 720
Query: 699 FTVGLLMYLRQ 709
G ++YL++
Sbjct: 721 LAAGFVVYLKR 731
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 351 bits (901), Expect = 1e-96
Identities = 224/695 (32%), Positives = 347/695 (49%), Gaps = 63/695 (9%)
Query: 20 GVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVK 79
GV L G S S ++ IP+K S P L+ L+ ++ ++++
Sbjct: 30 GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
Query: 80 KLLVSRHLPVFTYTDER---ALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGGFRGVL 136
+ L++ Y + +L + I CYYHG+V G +S V S C G RG++
Sbjct: 87 EGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLI 145
Query: 137 KISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAENSALE 196
+Y +EP++ SAT YK+ FPA + A +
Sbjct: 146 VFENESYVLEPMK-SATNR---YKL------FPAKKLKSVRGSCGSHHNTPNLAAKNVFP 195
Query: 197 PKSAGDWWTH-------AWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
P S H ++ELV+V ++ F ++ KV++ + + N VD Y+ L
Sbjct: 196 PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPL 255
Query: 250 GTYIILIGIEIWNQGNVF-----PMTSIEQVLNDFSQWKQISL-SQLQHDAAHM----FI 299
I+L+G+E+WN + P TS L++F W+++ L + HD A + +
Sbjct: 256 NIRIVLVGVEVWNDMDKCSVSQDPFTS----LHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
Query: 300 KNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD--EEFCF 357
+ + I G+A + +C G+ D A T+AHELGH GM HD + C
Sbjct: 312 QGTTI---GMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
Query: 358 CG----ERGCIMNT---FRVPAEKFTNCSYADFMKTTLNQGS--CLHNPPRLGEIFMLKR 408
C + GCIMN + P F++CS D ++T+L +G CL N P + E F ++
Sbjct: 369 CQMAVEKGGCIMNASTGYPFPMV-FSSCSRKD-LETSLEKGMGVCLFNLPEVRESFGGQK 426
Query: 409 CGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEV 468
CGN VE E+CDCG ++C C CTL+P A CA GLCC+DC+ P+G CR
Sbjct: 427 CGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
Query: 469 NECDLPEWCNGTSHQCPEDRYVQDGIPCSD-SAYCYQKRCNNHDQHCREIFGKDAKSASQ 527
N CDLPE+C G S CP + Y+ DG C D YCY C H+Q C ++G AK A
Sbjct: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
Query: 528 NCYKEINSQGNRFGHCG-INGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHI- 585
C++ +NS G+ +G+CG ++ +++ KC + D CG++QC+ P++ + T+I
Sbjct: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
Query: 586 ----NGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLS-HVCLPETCN 640
+ C G +L ++ D G V GT C GKIC++++C ++SV H C + C+
Sbjct: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ-CH 665
Query: 641 MKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGP 675
+G+CNN+ +CHC W+PP+C G+GGS DSGP
Sbjct: 666 GRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 349 bits (896), Expect = 4e-96
Identities = 215/679 (31%), Positives = 345/679 (50%), Gaps = 41/679 (6%)
Query: 17 LWLGVFLSISGYCQAGPSQHFTS--PEVVIPLKV---ISRGRSAKAPGWLSYSLRFGGQK 71
+W +FL +SG +F S ++ +P K+ I G ++A SY + G+
Sbjct: 1 MWRVLFL-LSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQA----SYKIVIEGKP 55
Query: 72 HVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGG 131
+ V++ K L + V++Y+ + + C+Y GY+EG P+S+V+ S C G
Sbjct: 56 YTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTG- 113
Query: 132 FRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAE 191
RGVL+ ++Y IEP+ S FEH++Y+V + EK++ + L F+
Sbjct: 114 LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYN----EKDIESRDLSFKL-- 167
Query: 192 NSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQLGT 251
++EP+ A ++E+ V+V + + S+ + V + VF ++ + ++++
Sbjct: 168 -QSVEPQQ-----DFAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNI 221
Query: 252 YIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLA 310
IIL +E+W N T ++L+ F +WK L HD A + + + +G
Sbjct: 222 TIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGAT 281
Query: 311 YVAGICRPPIDCGVDNFQGDTWSL--FANTVAHELGHTLGMQHDE-EFCFCGERGCIMNT 367
+ +C GV T SL A +A L ++G+ +D+ C C CIMN
Sbjct: 282 FQGKMCDANYAGGVV-LHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNP 340
Query: 368 FRVP---AEKFTNCSYADFMKTTLNQGS-CLHNPPRLGEIFMLKR-CGNGVVEREEQCDC 422
+ + F+NCS+ DF Q S CLHN PRL F + CGN +E E+CDC
Sbjct: 341 EAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDC 400
Query: 423 GSVQQCEQ--DACC-LLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNG 479
G+ Q C + CC + C + G+ CA G CC++C FM +CR ECDLPE+CNG
Sbjct: 401 GTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNG 460
Query: 480 TSHQCPEDRYVQDGIPCSDSAY-CYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGN 538
+S CPE+ YVQ G PC + + C C + D+ C + FGK+ + CY +NS+ +
Sbjct: 461 SSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTD 520
Query: 539 RFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLR 598
G+CGI+ + Y +C ++ CG++ C+ V L T+ + +I+G C +++
Sbjct: 521 VSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASD 580
Query: 599 MNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWS 658
S +KDGT CG K+C +++CVS S L + C + CN +G+CNNK HCHC +
Sbjct: 581 HADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYL 640
Query: 659 PPYCQHRG---YGGSIDSG 674
PP C + GGSIDSG
Sbjct: 641 PPDCSVQSDLWPGGSIDSG 659
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 339 bits (870), Expect = 5e-93
Identities = 201/619 (32%), Positives = 312/619 (50%), Gaps = 31/619 (5%)
Query: 105 IPDDCYYHGYVEGAPESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNS 163
+ D C+YHG V S V S C G RG++ +S L+Y IEP+ S +HL+Y+ S
Sbjct: 109 LEDHCFYHGTVRETELSSVTLSTC-RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--S 164
Query: 164 NETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAW-FLELVVVVNHDFFI 222
+ P CG + + + + + P+ ++ ++EL +V ++ F
Sbjct: 165 EHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQ 224
Query: 223 YSQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIE-QVLNDFSQ 281
++ + + + + N VD Y+ L I L+G+E+W GN+ ++ L F
Sbjct: 225 KNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLS 284
Query: 282 WKQISLSQLQHDAAHMFIKNSLI-SILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVA 340
W++ L+Q HD A + S + +GLA + +C GV+ + A T+A
Sbjct: 285 WRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMA 344
Query: 341 HELGHTLGMQHDEEFCF---CGERGCIMN--TFRVPAEKFTNCSYADFMKTTLNQGS-CL 394
HE+GH GM HD C + GCIM T + F C+ + + + G CL
Sbjct: 345 HEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCL 404
Query: 395 HNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKD 454
N P ++ +RCGNG +E E+CDCG ++C C NCTLRPGA CA G CC
Sbjct: 405 SNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQ 464
Query: 455 CKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPC-SDSAYCYQKRCNNHDQH 513
CK + G LCR++ +CDLPE+C G S CP + Y DG PC AYCY C + +
Sbjct: 465 CKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQ 524
Query: 514 CREIFGKDAKSASQNCYKEINSQGNRFGHCG--INGTTYLKCHISDVFCGRVQCENVRDI 571
C++++G A+ A C++++N G+ FG+CG +NG + KC++ D CG++QC++
Sbjct: 525 CQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNG-EHRKCNMRDAKCGKIQCQSSEAR 583
Query: 572 PLLQDHFTLQHTHI-NG--VTCWGIDYHL----RMNISDIGEVKDGTVCGPGKICIHKKC 624
PL + + T I NG + C G + ++ D G V GT CG IC +C
Sbjct: 584 PLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQC 643
Query: 625 VSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAK----- 679
+ S + CN G+CNN +CHC GW+PP+C G+GGSIDSGP +
Sbjct: 644 RNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPV 703
Query: 680 -RGVFLPLIVIPSLSVLTF 697
GV + ++V+ L ++ +
Sbjct: 704 VAGVLVAILVLAVLMLMYY 722
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 337 bits (863), Expect = 3e-92
Identities = 201/671 (29%), Positives = 342/671 (50%), Gaps = 28/671 (4%)
Query: 17 LWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGW--LSYSLRFGGQKHVV 74
LWL + + G + P + ++VIP K+ + + + +SY + + + V
Sbjct: 4 LWL-LLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTV 62
Query: 75 HMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGGFRG 134
H++ + L + ++ Y ++ ++ I CYY G +EG P+S+V S C G RG
Sbjct: 63 HLKQRYFLADNFM-IYLY-NQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRG 119
Query: 135 VLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAENSA 194
+L+ ++Y IEP+ + F+H++YK+ + + ++ + Q ++ +
Sbjct: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIF----IDRSLKEQPMDDNIFISEK 175
Query: 195 LEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQLGTYII 254
EP +LE+ +VV+ + Y S+ V V +V + +SM+ Q I+
Sbjct: 176 SEPAVPD---LFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIV 232
Query: 255 LIGIEIWNQGN-VFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLAYVA 313
L +E+W+ N + + +++L F +WKQ L+ HD A++ I LG +
Sbjct: 233 LSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPG 292
Query: 314 GICRPPIDCGVDNFQGD-TWSLFANTVAHELGHTLGMQHDE-EFCFCGERGCIMNTFRVP 371
+C GV + + T FA V L +LG+ +D+ + C C E CIMN V
Sbjct: 293 TMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQ 352
Query: 372 A---EKFTNCSYADFMKTTLNQG-SCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQ 427
+ + F++CS F N G CL N P++ + CGNG +E E CDCG+ Q
Sbjct: 353 SNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQ 412
Query: 428 CEQDACC-LLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVN-ECDLPEWCNGTSHQCP 485
C +CC C L+ GA C GLCCKDC+ + SG CR + + ECD+ E CNG+S +C
Sbjct: 413 CGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECG 472
Query: 486 EDRYVQDGIPCSDSAY-CYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCG 544
D + +G+ C ++ + CY C++ D C +FGK +++A CY+EI SQ +RFG+CG
Sbjct: 473 PDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCG 532
Query: 545 IN-GTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISD 603
+ Y+ C ++ CGR+ C P Q++ + + + C +DY L + D
Sbjct: 533 RDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPD 592
Query: 604 IGEVKDGTVCGPGKICIHKKCVSLSVL---SHVCLPETCNMKGICNNKHHCHCGYGWSPP 660
VK+G+ C G++C++++CV ++ +HVC + C+ G+C++++ CHC G+ PP
Sbjct: 593 PLAVKNGSQCDIGRVCVNRECVESRIIKASAHVC-SQQCSGHGVCDSRNKCHCSPGYKPP 651
Query: 661 YCQHRGYGGSI 671
CQ R G SI
Sbjct: 652 NCQIRSKGFSI 662
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 330 bits (845), Expect = 4e-90
Identities = 236/769 (30%), Positives = 359/769 (46%), Gaps = 86/769 (11%)
Query: 5 GTLVYIRVTLLLLW----LGVFLSISGYCQAGPSQHFTSPEVVI---PLKVISRGRSAKA 57
GT + + + LLLLW GV + G+ P +P V+ P + +S
Sbjct: 10 GTPLLLLLLLLLLWPVPGAGV---LQGHIPGQP----VTPHWVLDGQPWRTVSLEEPVSK 62
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIP---DDCYYHGY 114
P +L GQ+ ++ + L++ P + T + + P D C+Y G
Sbjct: 63 PDMGLVALEAEGQELLLELEKNHRLLA---PGYIETHYGPDGQPVVLAPNHTDHCHYQGR 119
Query: 115 VEGAPESLVVFSACFGGFRGVLKIS-GLTYEIEPI--RHSATFE-HLVYKVNSNET---- 166
V G P+S VV C G G++ +S +Y + P R S F H ++++ T
Sbjct: 120 VRGFPDSWVVLCTC-SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 178
Query: 167 ---QFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIY 223
+ P + G+T Q EA + +LEL +V +H F+
Sbjct: 179 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRK-------------YLELYIVADHTLFLT 225
Query: 224 SQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQW 282
N++ ++ + V N VD + + L + L G+E+W + + +T L F QW
Sbjct: 226 RHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQW 285
Query: 283 KQISLSQLQHDAAHMFIKNSLI-SILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAH 341
++ +Q HD+A + + + +GLA V G+CR GV + A T+AH
Sbjct: 286 RRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAH 345
Query: 342 ELGHTLGMQHDEEFCFCGER-----GCIMN--TFRVPAEKFTNCSY----ADFMKTTLNQ 390
E+GH+LG+ HD + C C E GC+M T F+ CS A F K
Sbjct: 346 EIGHSLGLSHDPDGC-CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRK---GG 401
Query: 391 GSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGL 450
G+CL N P G CGNG VE E+CDCG Q+C C NC+LRPGA CA G
Sbjct: 402 GACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGD 461
Query: 451 CCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNN 509
CC C P+G LCRQ + +CDLPE+C GTS CP D Y+ DG PC+ S YC+ C
Sbjct: 462 CCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPT 521
Query: 510 HDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENV 568
+Q C++++G + A + C++ +NS G+ G+CG + +L C D CG++QC+
Sbjct: 522 LEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG 581
Query: 569 RDIPLLQDHFTLQHT-HING--VTCWGIDY--HLRMNISDIGEVKDGTVCGPGKICIHKK 623
+ L + T H++G VTC G ++++ +G V+ GT CGP +C ++
Sbjct: 582 KPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRR 641
Query: 624 CVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKR--- 680
C + C+ G+CN+ H+CHC GW+PP+C G+GGS+DSGP A+
Sbjct: 642 CRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDT 701
Query: 681 -------GVFLPLIVIPSLSVLTFLFTVGLLMYLR-------QCSGPKE 715
V LPL+ L+ + L CSGPK+
Sbjct: 702 FLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD 750
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 314 bits (805), Expect = 2e-85
Identities = 198/651 (30%), Positives = 310/651 (47%), Gaps = 28/651 (4%)
Query: 42 VVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLED 101
V +P K+ S S + + Y + GQ + +H+ + L L V+TY + +L
Sbjct: 27 VTVPRKIKSND-SEVSERKMIYIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSV 84
Query: 102 QLFIPDDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKV 161
+ C+Y GY P S V S C G RG L+ ++Y IEP+ SA FEH++Y++
Sbjct: 85 SPYFMMHCHYQGYAAEFPNSFVTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQM 143
Query: 162 NSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFF 221
+N+ + + + ++ ++ NS ++ S +LE+ ++V +
Sbjct: 144 KNNDPNVSIL--AVNYSHIWQKDQPYKVPLNSQIKNLSK----LLPQYLEIYIIVEKALY 197
Query: 222 IYSQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIW-NQGNVFPMTSIEQVLNDFS 280
Y S + V + + V+ +V++M+ Q +IL +E+W N+ + + +L F
Sbjct: 198 DYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFL 257
Query: 281 QWKQISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSL--FANT 338
WK+ L HD A++ + +G + +C D G+ + D L F+
Sbjct: 258 AWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYP-DAIGLEGFSVI 316
Query: 339 VAHELGHTLGMQHDE-EFCFCGERGCIMNTFRVPAEK---FTNCSYADFMKTTLN-QGSC 393
+A LG +G+ +D+ CFC CIMN V A F+NCS D+ + C
Sbjct: 317 IAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKC 376
Query: 394 LHNPPRLGEIFMLKR-CGNGVVEREEQCDCGSVQQCEQDACCLLN-CTLRPGAACAFGLC 451
L L + + CGNG++E E+CDCG+ +C+ CC N C L+ C G C
Sbjct: 377 LQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPC 436
Query: 452 CKD-CKFMPSGELCRQEVN-ECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCN 508
C C+ +G CR+ ++ ECD E+CNGTS C D Y +G C +AYCY +C
Sbjct: 437 CTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQ 496
Query: 509 NHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENV 568
D C +IFGK A+ A C+KE+NS R +CG + L C DV CG++ C
Sbjct: 497 TTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQP 556
Query: 569 RDIPLLQDHFTLQHTHINGVTCWGI--DYHLRMNISDIGEVKDGTVCGPGKICIHKKCVS 626
D + +++I C I +R + +D V DGT+CGP C++K C
Sbjct: 557 HKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRK 616
Query: 627 LSVLSHVCLPET-CNMKGICNNKHHCHCGYGWSPPYC--QHRGYGGSIDSG 674
+ ++ + C T C KGICNN +C C G PP C Q GGSID G
Sbjct: 617 VHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 311 bits (796), Expect = 2e-84
Identities = 232/769 (30%), Positives = 351/769 (45%), Gaps = 112/769 (14%)
Query: 5 GTLVYIRVTLLLLW----LGVFLSISGYCQAGPSQHFTSPEVVI---PLKVISRGRSAKA 57
GT + + + LLLLW GV + G+ P +P V+ P + +S
Sbjct: 10 GTPLLLLLLLLLLWPVPGAGV---LQGHIPGQP----VTPHWVLDGQPWRTVSLEEPVSK 62
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIP---DDCYYHGY 114
P +L GQ+ ++ + L++ P + T + + P D C+Y G
Sbjct: 63 PDMGLVALEAEGQELLLELEKNHRLLA---PGYIETHYGPDGQPVVLAPNHTDHCHYQGR 119
Query: 115 VEGAPESLVVFSACFGGFRGVLKIS-GLTYEIEPI--RHSATFE-HLVYKVNSNET---- 166
V G P+S VV C G G++ +S +Y + P R S F H ++++ T
Sbjct: 120 VRGFPDSWVVLCTC-SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 178
Query: 167 ---QFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIY 223
+ P + G+T Q EA + +LEL +V +H F+
Sbjct: 179 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRK-------------YLELYIVADHTLFLT 225
Query: 224 SQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQW 282
N++ ++ + V N VD + + L + L G+E+W + + +T L F QW
Sbjct: 226 RHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQW 285
Query: 283 KQISLSQLQHDAAHMFIKNSLI-SILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAH 341
++ +Q HD+A + + + +GLA V G+CR GV + A T+AH
Sbjct: 286 RRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAH 345
Query: 342 ELGHTLGMQHDEEFCFCGER-----GCIMN--TFRVPAEKFTNCSY----ADFMKTTLNQ 390
E+GH+LG+ HD + C C E GC+M T F+ CS A F K
Sbjct: 346 EIGHSLGLSHDPDGC-CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRK---GG 401
Query: 391 GSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGL 450
G+CL N P G CGNG VE E+CDCG Q+C C NC+LRPGA CA G
Sbjct: 402 GACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGD 461
Query: 451 CCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNN 509
CC C P+G LCRQ + +CDLPE+C GTS CP D Y+ DG PC+ S YC+ C
Sbjct: 462 CCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPT 521
Query: 510 HDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENV 568
+Q C++++G + A + C++ +NS G+ G+CG + +L C D CG++QC+
Sbjct: 522 LEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG 581
Query: 569 RDIPLLQDHFTLQHT-HING--VTCWGIDY--HLRMNISDIGEVKDGTVCGPGKICIHKK 623
+ L + T H++G VTC G ++++ +G V+ GT CGP
Sbjct: 582 KPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGP-------- 633
Query: 624 CVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKR--- 680
+ +CN+ H+CHC GW+PP+C G+GGS+DSGP A+
Sbjct: 634 ------------------RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDT 675
Query: 681 -------GVFLPLIVIPSLSVLTFLFTVGLLMYLR-------QCSGPKE 715
V LPL+ L+ + L CSGPK+
Sbjct: 676 FLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD 724
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 299 bits (766), Expect = 5e-81
Identities = 201/701 (28%), Positives = 326/701 (46%), Gaps = 56/701 (7%)
Query: 41 EVVIPLKVIS-RGRSAKAPGW-------LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTY 92
EVV P+++ R AK P L Y + G+ V++++ K L++ Y
Sbjct: 29 EVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYY 88
Query: 93 TDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIR--H 150
+ I DDCYY G++ S S C G RG Y IEP+ H
Sbjct: 89 NSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTC-RGLRGYFSQGDQRYFIEPLSPIH 147
Query: 151 SATFEHLVYKVNSNETQFPAMRCGLTEKEVA---RQQLEFEEAENSALEPKSAGDWWTHA 207
EH ++K N +E + + CG+ A +Q + + L+ + + H
Sbjct: 148 RDGQEHALFKYNPDEKNYDST-CGMDGVLWAHDLQQNIALPATKLVKLKDRKVQE---HE 203
Query: 208 WFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVF 267
++E +V+++ F N ++++ VF + N V+ +Y++L T++ L+G+EIW +
Sbjct: 204 KYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKI 263
Query: 268 PMT-SIEQVLNDFSQWKQISLSQLQ-HDAAHMFIKNSLI-SILGLAYVAGICRPPIDCGV 324
+T + L +FS+W+ LS+ + HD A + L + +GLA+++ +C P GV
Sbjct: 264 KITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGV 322
Query: 325 DNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMN---TFRVPAEKFTNCS-- 379
D A T+AHE+GH GM HD+ C C C+M+ +F +P + F++CS
Sbjct: 323 VQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTD-FSSCSRL 381
Query: 380 -YADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNC 438
Y F + L+ +CL N P +I CGN +VE E CDCG+ ++C C C
Sbjct: 382 SYDKFFEDKLS--NCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTC 439
Query: 439 TLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPC-S 497
++ CA G CC+ C+F +G +CR +ECDLPE CNG S CP+DR+ +G PC
Sbjct: 440 KIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHH 499
Query: 498 DSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISD 557
+C C + C E++G + A ++CY N G+++G+C T + C +D
Sbjct: 500 GKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKAND 558
Query: 558 VFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCGPGK 617
CG++ C+ D+ + + +TC D +IG V +GT CG K
Sbjct: 559 TMCGKLFCQGG------SDNLPWKGRIVTFLTCKTFD--PEDTSQEIGMVANGTKCGDNK 610
Query: 618 ICIHKKCVSL-SVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPA 676
+CI+ +CV + C +C+++ C C GW PP C
Sbjct: 611 VCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSV--------- 661
Query: 677 SAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
VF IV+ L + +F V ++ Q S K+ K
Sbjct: 662 -----VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKK 697
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 298 bits (763), Expect = 1e-80
Identities = 198/667 (29%), Positives = 320/667 (47%), Gaps = 35/667 (5%)
Query: 61 LSYSLRFGGQKHVVHM-RVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAP 119
L Y ++ + V+H+ R ++ L S + F Y+ + I D C+Y G +
Sbjct: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117
Query: 120 ESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKE 179
+S S C G RG +I+ Y IEP+++S EHLV+K N C TE
Sbjct: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSC--TELN 174
Query: 180 VARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVV 239
R+ + + + K D ++EL +V + + + +K++ ++ +V
Sbjct: 175 FTRKTVPGDNESEEDSKIKGIHD----EKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230
Query: 240 NIVDSMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQISLSQLQHDAAHMF 298
N V+ +Y+ L ++ L+GIEIW + + S IE L FS W++ + + + D H+
Sbjct: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQE-KILKTRKDFDHVV 289
Query: 299 IKNS---LISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEF 355
+ + + G++Y G+C P + ++ AN +AH+LGH LGMQHDE
Sbjct: 290 LLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFP 349
Query: 356 CFCGERGCIMNTF-RVPAEKFTNCS---YADFMKTTLNQGSCLHNPPRLGEIFMLKRCGN 411
C C C+M++ +PA KF+ CS Y ++K + +C+ N P + CGN
Sbjct: 350 CTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDY--KPTCMLNIPFPYNFHDFQFCGN 407
Query: 412 GVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNEC 471
++ E+CDCG Q+C C C L+PG CA G CC+ C+ +G +CR +EC
Sbjct: 408 KKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDEC 467
Query: 472 DLPEWCNGTSHQCPEDRYVQDGIPCSDS-AYCYQKRCNNHDQHCREIFGKDAKSASQNCY 530
D PE C G S CP+D++ +G PC +S YC+ +C + C E+F +A + CY
Sbjct: 468 DFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY 527
Query: 531 KEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFT--LQHTHING- 587
K +N++GN+FG+C +L C DV CG++ C LL + T L+ N
Sbjct: 528 K-MNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNAT 586
Query: 588 VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSL-SVLSHVCLPETCNMKGICN 646
V C I L + +DIG V GT CG G +C + +C+++ V P CN +
Sbjct: 587 VKCKTI--FLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDG 644
Query: 647 NKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMY 706
+ CHC G +P C+ + +I V + ++VI + VL L +
Sbjct: 645 HGLQCHCEEGQAPVACEETLHVTNITI-------LVVVLVLVIVGIGVLILLVRYRKCIK 697
Query: 707 LRQCSGP 713
L+Q P
Sbjct: 698 LKQVQSP 704
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 285 bits (729), Expect = 1e-76
Identities = 207/693 (29%), Positives = 320/693 (46%), Gaps = 45/693 (6%)
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117
P L L G H++ + + LV + Y + + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176
S V C G RG++ ++ +Y +E ++ ++ + P C L+
Sbjct: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
Query: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236
+E Q E + D T +ELV+V +H + +
Sbjct: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
Query: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294
V ++D+ ++ L + L+G+E W Q ++ ++ V L +F W++ L +L HD+
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352
A + S +G+A IC P GV+ + A+++AHELGH+LG+ HD
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399
C C + CIM +T +P F+NCS K L+ GSCL PP
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
Query: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458
M CGN VE EQCDCG + C C L C LRPGA CA G CC++C+
Sbjct: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517
PSG CR +CDLPE+C G S QCP D + DG PC+ A C RC ++ Q C+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576
+G A+ A+ C + N++GN FG CG N + +Y+ C D CG++QC+ R PLL
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632
L + +NG + C + L +++ GT CGPG +CI +C + +L
Sbjct: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692
C+ G+C++ HC+C GW+PP C + +S G+ L L+V+ L
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
Query: 693 SVL--TFLFTVGLLMYLRQCSGPK-ETKAHSSG 722
+L ++ + L L Q GP + +A SG
Sbjct: 709 VMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 285 bits (729), Expect = 1e-76
Identities = 207/693 (29%), Positives = 320/693 (46%), Gaps = 45/693 (6%)
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117
P L L G H++ + + LV + Y + + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176
S V C G RG++ ++ +Y +E ++ ++ + P C L+
Sbjct: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
Query: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236
+E Q E + D T +ELV+V +H + +
Sbjct: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
Query: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294
V ++D+ ++ L + L+G+E W Q ++ ++ V L +F W++ L +L HD+
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352
A + S +G+A IC P GV+ + A+++AHELGH+LG+ HD
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399
C C + CIM +T +P F+NCS K L+ GSCL PP
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
Query: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458
M CGN VE EQCDCG + C C L C LRPGA CA G CC++C+
Sbjct: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517
PSG CR +CDLPE+C G S QCP D + DG PC+ A C RC ++ Q C+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576
+G A+ A+ C + N++GN FG CG N + +Y+ C D CG++QC+ R PLL
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632
L + +NG + C + L +++ GT CGPG +CI +C + +L
Sbjct: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692
C+ G+C++ HC+C GW+PP C + +S G+ L L+V+ L
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
Query: 693 SVL--TFLFTVGLLMYLRQCSGPK-ETKAHSSG 722
+L ++ + L L Q GP + +A SG
Sbjct: 709 VMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 285 bits (729), Expect = 1e-76
Identities = 207/693 (29%), Positives = 320/693 (46%), Gaps = 45/693 (6%)
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117
P L L G H++ + + LV + Y + + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176
S V C G RG++ ++ +Y +E ++ ++ + P C L+
Sbjct: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
Query: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236
+E Q E + D T +ELV+V +H + +
Sbjct: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
Query: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294
V ++D+ ++ L + L+G+E W Q ++ ++ V L +F W++ L +L HD+
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352
A + S +G+A IC P GV+ + A+++AHELGH+LG+ HD
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399
C C + CIM +T +P F+NCS K L+ GSCL PP
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
Query: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458
M CGN VE EQCDCG + C C L C LRPGA CA G CC++C+
Sbjct: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517
PSG CR +CDLPE+C G S QCP D + DG PC+ A C RC ++ Q C+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576
+G A+ A+ C + N++GN FG CG N + +Y+ C D CG++QC+ R PLL
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632
L + +NG + C + L +++ GT CGPG +CI +C + +L
Sbjct: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692
C+ G+C++ HC+C GW+PP C + +S G+ L L+V+ L
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
Query: 693 SVL--TFLFTVGLLMYLRQCSGPK-ETKAHSSG 722
+L ++ + L L Q GP + +A SG
Sbjct: 709 VMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 285 bits (729), Expect = 1e-76
Identities = 207/693 (29%), Positives = 320/693 (46%), Gaps = 45/693 (6%)
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117
P L L G H++ + + LV + Y + + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176
S V C G RG++ ++ +Y +E ++ ++ + P C L+
Sbjct: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
Query: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236
+E Q E + D T +ELV+V +H + +
Sbjct: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
Query: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294
V ++D+ ++ L + L+G+E W Q ++ ++ V L +F W++ L +L HD+
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352
A + S +G+A IC P GV+ + A+++AHELGH+LG+ HD
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399
C C + CIM +T +P F+NCS K L+ GSCL PP
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
Query: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458
M CGN VE EQCDCG + C C L C LRPGA CA G CC++C+
Sbjct: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517
PSG CR +CDLPE+C G S QCP D + DG PC+ A C RC ++ Q C+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576
+G A+ A+ C + N++GN FG CG N + +Y+ C D CG++QC+ R PLL
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632
L + +NG + C + L +++ GT CGPG +CI +C + +L
Sbjct: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692
C+ G+C++ HC+C GW+PP C + +S G+ L L+V+ L
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
Query: 693 SVL--TFLFTVGLLMYLRQCSGPK-ETKAHSSG 722
+L ++ + L L Q GP + +A SG
Sbjct: 709 VMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 285 bits (729), Expect = 1e-76
Identities = 207/693 (29%), Positives = 320/693 (46%), Gaps = 45/693 (6%)
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117
P L L G H++ + + LV + Y + + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176
S V C G RG++ ++ +Y +E ++ ++ + P C L+
Sbjct: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
Query: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236
+E Q E + D T +ELV+V +H + +
Sbjct: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
Query: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294
V ++D+ ++ L + L+G+E W Q ++ ++ V L +F W++ L +L HD+
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352
A + S +G+A IC P GV+ + A+++AHELGH+LG+ HD
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399
C C + CIM +T +P F+NCS K L+ GSCL PP
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
Query: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458
M CGN VE EQCDCG + C C L C LRPGA CA G CC++C+
Sbjct: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517
PSG CR +CDLPE+C G S QCP D + DG PC+ A C RC ++ Q C+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576
+G A+ A+ C + N++GN FG CG N + +Y+ C D CG++QC+ R PLL
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632
L + +NG + C + L +++ GT CGPG +CI +C + +L
Sbjct: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692
C+ G+C++ HC+C GW+PP C + +S G+ L L+V+ L
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
Query: 693 SVL--TFLFTVGLLMYLRQCSGPK-ETKAHSSG 722
+L ++ + L L Q GP + +A SG
Sbjct: 709 VMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 285 bits (728), Expect = 1e-76
Identities = 204/683 (29%), Positives = 315/683 (46%), Gaps = 44/683 (6%)
Query: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117
P L L G H++ + + LV + Y + + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176
S V C G RG++ ++ +Y +E ++ ++ + P C L+
Sbjct: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
Query: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236
+E Q E + D T +ELV+V +H + +
Sbjct: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
Query: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294
V ++D+ ++ L + L+G+E W Q ++ ++ V L +F W++ L +L HD+
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352
A + S +G+A IC P GV+ + A+++AHELGH+LG+ HD
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399
C C + CIM +T +P F+NCS K L+ GSCL PP
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
Query: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458
M CGN VE EQCDCG + C C L C LRPGA CA G CC++C+
Sbjct: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517
PSG CR +CDLPE+C G S QCP D + DG PC+ A C RC ++ Q C+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576
+G A+ A+ C + N++GN FG CG N + +Y+ C D CG++QC+ R PLL
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632
L + +NG + C + L +++ GT CGPG +CI +C + +L
Sbjct: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692
C+ G+C++ HC+C GW+PP C + +S G+ L L+V+ L
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
Query: 693 SVL--TFLFTVGLLMYLRQCSGP 713
+L ++ + L L Q GP
Sbjct: 709 VMLGASYWYRARLHQRLCQLKGP 731
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 277 bits (709), Expect = 2e-74
Identities = 183/593 (30%), Positives = 294/593 (49%), Gaps = 51/593 (8%)
Query: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFE----HLVYKVN 162
+ CYY G++ G P+S V S C G G+ TY IEP + T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 163 SNETQFPAMRCGLTEKEVARQQLEFEEAENSALE-----PKSAGDWWTHAWFLELVVVVN 217
E + + + + + + P++ + ++EL++V +
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEE---ETKYIELMIVND 248
Query: 218 HDFFIYSQSNISKVQEDVFL--VVNIVDSMYQ-QLGTYIILIGIEIWNQGNVFPMTSIEQ 274
H ++ + +S V + + VVN+ D +Y+ QL T I+L+ +E W N F ++
Sbjct: 249 H--LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPL 306
Query: 275 V-LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTW 332
+ L +F ++++ + + + DA H+F + S G AY+ GIC GV+ F G T
Sbjct: 307 ITLREFMKYRRDFIKE-KSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF-GKT- 363
Query: 333 SLFANTVAHELGHTLGMQHDEEFCFCGE-------RGCIM-NTFRVPAEKFTNCS---YA 381
L A T+A L H +G+ D+ GE GCIM +T +KFT C+ Y
Sbjct: 364 DLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYH 423
Query: 382 DFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCE-QDACCLLNCTL 440
DF+ + G+CL N P ++ CGNG +E E+CDCG+ +C + A C CTL
Sbjct: 424 DFLNS--GGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTL 479
Query: 441 RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSD-S 499
+ C+ GLCCK CKF P G +CR+ VN+CD+ E C+G S QC + + DG C
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
Query: 500 AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVF 559
C+ RC D+ C+ I+G+ ++ + CY+++N +G G+CG + T+++C+ DV
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
Query: 560 CGRVQCENVRDIPLLQD-----HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614
CG + C N+ +IP L + TL + C G L ++ D+G V+DGT CG
Sbjct: 600 CGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCG 658
Query: 615 PGKICIHKKCVSLSVLS-HVCLPE----TCNMKGICNNKHHCHCGYGWSPPYC 662
P +C+ +C+ ++ + CL C+ G+C+N+ C C W C
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 277 bits (709), Expect = 2e-74
Identities = 183/593 (30%), Positives = 294/593 (49%), Gaps = 51/593 (8%)
Query: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFE----HLVYKVN 162
+ CYY G++ G P+S V S C G G+ TY IEP + T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 163 SNETQFPAMRCGLTEKEVARQQLEFEEAENSALE-----PKSAGDWWTHAWFLELVVVVN 217
E + + + + + + P++ + ++EL++V +
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEE---ETKYIELMIVND 248
Query: 218 HDFFIYSQSNISKVQEDVFL--VVNIVDSMYQ-QLGTYIILIGIEIWNQGNVFPMTSIEQ 274
H ++ + +S V + + VVN+ D +Y+ QL T I+L+ +E W N F ++
Sbjct: 249 H--LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPL 306
Query: 275 V-LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTW 332
+ L +F ++++ + + + DA H+F + S G AY+ GIC GV+ F G T
Sbjct: 307 ITLREFMKYRRDFIKE-KSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF-GKT- 363
Query: 333 SLFANTVAHELGHTLGMQHDEEFCFCGE-------RGCIM-NTFRVPAEKFTNCS---YA 381
L A T+A L H +G+ D+ GE GCIM +T +KFT C+ Y
Sbjct: 364 DLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYH 423
Query: 382 DFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCE-QDACCLLNCTL 440
DF+ + G+CL N P ++ CGNG +E E+CDCG+ +C + A C CTL
Sbjct: 424 DFLNS--GGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTL 479
Query: 441 RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSD-S 499
+ C+ GLCCK CKF P G +CR+ VN+CD+ E C+G S QC + + DG C
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
Query: 500 AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVF 559
C+ RC D+ C+ I+G+ ++ + CY+++N +G G+CG + T+++C+ DV
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
Query: 560 CGRVQCENVRDIPLLQD-----HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614
CG + C N+ +IP L + TL + C G L ++ D+G V+DGT CG
Sbjct: 600 CGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCG 658
Query: 615 PGKICIHKKCVSLSVLS-HVCLPE----TCNMKGICNNKHHCHCGYGWSPPYC 662
P +C+ +C+ ++ + CL C+ G+C+N+ C C W C
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 277 bits (709), Expect = 2e-74
Identities = 183/593 (30%), Positives = 294/593 (49%), Gaps = 51/593 (8%)
Query: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFE----HLVYKVN 162
+ CYY G++ G P+S V S C G G+ TY IEP + T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 163 SNETQFPAMRCGLTEKEVARQQLEFEEAENSALE-----PKSAGDWWTHAWFLELVVVVN 217
E + + + + + + P++ + ++EL++V +
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEE---ETKYIELMIVND 248
Query: 218 HDFFIYSQSNISKVQEDVFL--VVNIVDSMYQ-QLGTYIILIGIEIWNQGNVFPMTSIEQ 274
H ++ + +S V + + VVN+ D +Y+ QL T I+L+ +E W N F ++
Sbjct: 249 H--LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPL 306
Query: 275 V-LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTW 332
+ L +F ++++ + + + DA H+F + S G AY+ GIC GV+ F G T
Sbjct: 307 ITLREFMKYRRDFIKE-KSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF-GKT- 363
Query: 333 SLFANTVAHELGHTLGMQHDEEFCFCGE-------RGCIM-NTFRVPAEKFTNCS---YA 381
L A T+A L H +G+ D+ GE GCIM +T +KFT C+ Y
Sbjct: 364 DLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYH 423
Query: 382 DFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCE-QDACCLLNCTL 440
DF+ + G+CL N P ++ CGNG +E E+CDCG+ +C + A C CTL
Sbjct: 424 DFLNS--GGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTL 479
Query: 441 RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSD-S 499
+ C+ GLCCK CKF P G +CR+ VN+CD+ E C+G S QC + + DG C
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
Query: 500 AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVF 559
C+ RC D+ C+ I+G+ ++ + CY+++N +G G+CG + T+++C+ DV
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
Query: 560 CGRVQCENVRDIPLLQD-----HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614
CG + C N+ +IP L + TL + C G L ++ D+G V+DGT CG
Sbjct: 600 CGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCG 658
Query: 615 PGKICIHKKCVSLSVLS-HVCLPE----TCNMKGICNNKHHCHCGYGWSPPYC 662
P +C+ +C+ ++ + CL C+ G+C+N+ C C W C
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 277 bits (709), Expect = 2e-74
Identities = 183/593 (30%), Positives = 294/593 (49%), Gaps = 51/593 (8%)
Query: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFE----HLVYKVN 162
+ CYY G++ G P+S V S C G G+ TY IEP + T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 163 SNETQFPAMRCGLTEKEVARQQLEFEEAENSALE-----PKSAGDWWTHAWFLELVVVVN 217
E + + + + + + P++ + ++EL++V +
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEE---ETKYIELMIVND 248
Query: 218 HDFFIYSQSNISKVQEDVFL--VVNIVDSMYQ-QLGTYIILIGIEIWNQGNVFPMTSIEQ 274
H ++ + +S V + + VVN+ D +Y+ QL T I+L+ +E W N F ++
Sbjct: 249 H--LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPL 306
Query: 275 V-LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTW 332
+ L +F ++++ + + + DA H+F + S G AY+ GIC GV+ F G T
Sbjct: 307 ITLREFMKYRRDFIKE-KSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF-GKT- 363
Query: 333 SLFANTVAHELGHTLGMQHDEEFCFCGE-------RGCIM-NTFRVPAEKFTNCS---YA 381
L A T+A L H +G+ D+ GE GCIM +T +KFT C+ Y
Sbjct: 364 DLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYH 423
Query: 382 DFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCE-QDACCLLNCTL 440
DF+ + G+CL N P ++ CGNG +E E+CDCG+ +C + A C CTL
Sbjct: 424 DFLNS--GGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTL 479
Query: 441 RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSD-S 499
+ C+ GLCCK CKF P G +CR+ VN+CD+ E C+G S QC + + DG C
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
Query: 500 AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVF 559
C+ RC D+ C+ I+G+ ++ + CY+++N +G G+CG + T+++C+ DV
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
Query: 560 CGRVQCENVRDIPLLQD-----HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614
CG + C N+ +IP L + TL + C G L ++ D+G V+DGT CG
Sbjct: 600 CGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCG 658
Query: 615 PGKICIHKKCVSLSVLS-HVCLPE----TCNMKGICNNKHHCHCGYGWSPPYC 662
P +C+ +C+ ++ + CL C+ G+C+N+ C C W C
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 277 bits (709), Expect = 2e-74
Identities = 183/593 (30%), Positives = 294/593 (49%), Gaps = 51/593 (8%)
Query: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFE----HLVYKVN 162
+ CYY G++ G P+S V S C G G+ TY IEP + T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 163 SNETQFPAMRCGLTEKEVARQQLEFEEAENSALE-----PKSAGDWWTHAWFLELVVVVN 217
E + + + + + + P++ + ++EL++V +
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEE---ETKYIELMIVND 248
Query: 218 HDFFIYSQSNISKVQEDVFL--VVNIVDSMYQ-QLGTYIILIGIEIWNQGNVFPMTSIEQ 274
H ++ + +S V + + VVN+ D +Y+ QL T I+L+ +E W N F ++
Sbjct: 249 H--LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPL 306
Query: 275 V-LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTW 332
+ L +F ++++ + + + DA H+F + S G AY+ GIC GV+ F G T
Sbjct: 307 ITLREFMKYRRDFIKE-KSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF-GKT- 363
Query: 333 SLFANTVAHELGHTLGMQHDEEFCFCGE-------RGCIM-NTFRVPAEKFTNCS---YA 381
L A T+A L H +G+ D+ GE GCIM +T +KFT C+ Y
Sbjct: 364 DLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYH 423
Query: 382 DFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCE-QDACCLLNCTL 440
DF+ + G+CL N P ++ CGNG +E E+CDCG+ +C + A C CTL
Sbjct: 424 DFLNS--GGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTL 479
Query: 441 RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSD-S 499
+ C+ GLCCK CKF P G +CR+ VN+CD+ E C+G S QC + + DG C
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
Query: 500 AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVF 559
C+ RC D+ C+ I+G+ ++ + CY+++N +G G+CG + T+++C+ DV
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
Query: 560 CGRVQCENVRDIPLLQD-----HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614
CG + C N+ +IP L + TL + C G L ++ D+G V+DGT CG
Sbjct: 600 CGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCG 658
Query: 615 PGKICIHKKCVSLSVLS-HVCLPE----TCNMKGICNNKHHCHCGYGWSPPYC 662
P +C+ +C+ ++ + CL C+ G+C+N+ C C W C
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 274 bits (700), Expect = 2e-73
Identities = 182/593 (30%), Positives = 290/593 (48%), Gaps = 49/593 (8%)
Query: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIR-----HSATFEHLVYKV 161
+ CYYHG + G +S V S C G G+ + Y IEP+ S H++ K
Sbjct: 194 EHCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKT 252
Query: 162 NSNE--TQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHD 219
+ + Q + ++ +L++ + A+ P + +LEL++V +H
Sbjct: 253 LAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRG--IFEEMKYLELMIVNDHK 310
Query: 220 FFIYSQSNISKVQEDVFLVVNIVDSMY-QQLGTYIILIGIEIWNQGNVFPMTSIE-QVLN 277
+ +S+ + VVN+VDS+Y +QL T ++L+ +E W + + +T+ Q+L+
Sbjct: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370
Query: 278 DFSQWKQISLSQLQH-DAAHMFIKNSL-ISILGLAYVAGICRPPIDCGVDNFQGDTWSLF 335
+FS+++Q QH DA H+ + + L+Y G+C GV+ +
Sbjct: 371 EFSKYRQ---RIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEY--GLPMAV 425
Query: 336 ANTVAHELGHTLGMQHDEEF----CFCGER--GCIMNTFRVP-AEKFTNCS---YADFMK 385
A ++ L LG+Q + C C E GCIM V + KF+ CS Y DF++
Sbjct: 426 AQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQ 485
Query: 386 TTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAA 445
G+CL N P ++F CGNG VE E+CDCG +C C C+L GA
Sbjct: 486 R--GGGACLFNRPT--KLFEPTECGNGYVEAGEECDCGFHVECY--GLCCKKCSLSNGAH 539
Query: 446 CAFGLCCKD--CKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSDS-AYC 502
C+ G CC + C F P G CR VNECD+ E+C G S QCP + + QDG C+ + C
Sbjct: 540 CSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRC 599
Query: 503 YQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGR 562
Y C D C+ I+G A + + CY+++N++G G+CG +G +++C DVFCG
Sbjct: 600 YNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGF 659
Query: 563 VQCENVRDIP---LLQDHFTLQHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGK 617
+ C N+ P LQ + G + C G L + +D+G V+DGT CGP
Sbjct: 660 LLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSM 718
Query: 618 ICIHKKCVSLSVLSHVCLP-----ETCNMKGICNNKHHCHCGYGWSPPYCQHR 665
+C+ +KC+ + L+ P + C+ G+C+N+ C C + W+ C R
Sbjct: 719 MCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR 771
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.459
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,536,050
Number of Sequences: 37866
Number of extensions: 1467026
Number of successful extensions: 4577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 3891
Number of HSP's gapped (non-prelim): 470
length of query: 722
length of database: 18,247,518
effective HSP length: 110
effective length of query: 612
effective length of database: 14,082,258
effective search space: 8618341896
effective search space used: 8618341896
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.