Guide to the Human Genome
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Search of human proteins with 114155142

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
         (2363 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|114155142 nuclear pore complex-associated protein TPR [Homo s...  4521   0.0  
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    241   8e-63
gi|21735548 centrosomal protein 2 [Homo sapiens]                      239   2e-62
gi|71061468 centromere protein E [Homo sapiens]                       237   9e-62
gi|148746195 trichohyalin [Homo sapiens]                              221   7e-57
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   216   3e-55
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        207   1e-52
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            206   2e-52
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       206   2e-52
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       206   2e-52
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        206   2e-52
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        206   2e-52
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        206   2e-52
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        206   2e-52
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        206   2e-52
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        206   2e-52
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    202   2e-51
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                202   3e-51
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   199   3e-50
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    187   8e-47
gi|55770834 centromere protein F [Homo sapiens]                       186   2e-46
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]        183   2e-45
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]        182   3e-45
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   180   1e-44
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   180   2e-44
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   177   8e-44
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               177   1e-43
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   175   5e-43
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   175   5e-43
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   174   7e-43

>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 4521 bits (11725), Expect = 0.0
 Identities = 2363/2363 (100%), Positives = 2363/2363 (100%)

Query: 1    MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR 60
            MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR
Sbjct: 1    MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR 60

Query: 61   LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
            LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL
Sbjct: 61   LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120

Query: 121  EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
            EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE
Sbjct: 121  EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180

Query: 181  KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
            KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM
Sbjct: 181  KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240

Query: 241  NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
            NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS
Sbjct: 241  NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300

Query: 301  NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
            NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL
Sbjct: 301  NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360

Query: 361  SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
            SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN
Sbjct: 361  SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420

Query: 421  KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
            KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS
Sbjct: 421  KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480

Query: 481  VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
            VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY
Sbjct: 481  VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540

Query: 541  RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ 600
            RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ
Sbjct: 541  RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ 600

Query: 601  MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660
            MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI
Sbjct: 601  MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660

Query: 661  ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
            ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF
Sbjct: 661  ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720

Query: 721  ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR 780
            ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR
Sbjct: 721  ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR 780

Query: 781  AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840
            AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ
Sbjct: 781  AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840

Query: 841  IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
            IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE
Sbjct: 841  IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900

Query: 901  IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
            IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS
Sbjct: 901  IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960

Query: 961  NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD 1020
            NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD
Sbjct: 961  NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD 1020

Query: 1021 DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN 1080
            DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN
Sbjct: 1021 DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN 1080

Query: 1081 KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD 1140
            KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD
Sbjct: 1081 KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD 1140

Query: 1141 EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL 1200
            EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL
Sbjct: 1141 EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL 1200

Query: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE 1260
            RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE
Sbjct: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE 1260

Query: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM 1320
            ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM
Sbjct: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM 1320

Query: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA 1380
            LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA
Sbjct: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA 1380

Query: 1381 EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR 1440
            EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR
Sbjct: 1381 EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR 1440

Query: 1441 YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
            YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL
Sbjct: 1441 YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500

Query: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560
            QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA
Sbjct: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560

Query: 1561 KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH 1620
            KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH
Sbjct: 1561 KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH 1620

Query: 1621 QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK 1680
            QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK
Sbjct: 1621 QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK 1680

Query: 1681 VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPV 1740
            VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPV
Sbjct: 1681 VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPV 1740

Query: 1741 FGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800
            FGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV
Sbjct: 1741 FGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800

Query: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK 1860
            VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK
Sbjct: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK 1860

Query: 1861 SVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDL 1920
            SVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDL
Sbjct: 1861 SVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDL 1920

Query: 1921 GPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTG 1980
            GPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTG
Sbjct: 1921 GPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTG 1980

Query: 1981 MGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEG 2040
            MGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEG
Sbjct: 1981 MGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEG 2040

Query: 2041 NTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR 2100
            NTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR
Sbjct: 2041 NTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR 2100

Query: 2101 IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAG 2160
            IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAG
Sbjct: 2101 IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAG 2160

Query: 2161 VPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAA 2220
            VPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAA
Sbjct: 2161 VPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAA 2220

Query: 2221 PVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAG 2280
            PVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAG
Sbjct: 2221 PVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAG 2280

Query: 2281 LEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQ 2340
            LEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQ
Sbjct: 2281 LEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQ 2340

Query: 2341 FNRQRGVSHAMGGRGGINRGNIN 2363
            FNRQRGVSHAMGGRGGINRGNIN
Sbjct: 2341 FNRQRGVSHAMGGRGGINRGNIN 2363


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  241 bits (614), Expect = 8e-63
 Identities = 386/1768 (21%), Positives = 764/1768 (43%), Gaps = 269/1768 (15%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKF--KVESEQQYFEI-EKRL 61
            LQ +L +++ +K  + +    E+   DQQ++    K   E+F   +E + QY  + + ++
Sbjct: 174  LQGILSQSQ-DKSLRRIAELREELQMDQQAK----KHLQEEFDASLEEKDQYISVLQTQV 228

Query: 62   SHSQERLVNETRECQSLRLELEKLNNQLKALT-EKNKELEIAQDRNIAIQSQFTRTKEEL 120
            S  ++RL N       L+  L +L  Q +  T E+N E +                  E 
Sbjct: 229  SLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESD-----------------GEP 270

Query: 121  EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
              E    ++T E L Q ++     +KR  E ++     K +  L   E +A    +  R 
Sbjct: 271  VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSH---KEQCTLLTSEKEALQEQLDERL 327

Query: 181  KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC----NLENKKEEVSRL 236
            + LE+ K+L  ++ T L T+L+   + +  L ++KG  I E K      LE K+EE+++L
Sbjct: 328  QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387

Query: 237  EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
              ++  + T  E L++  E         K ++A+ EE           L     +A    
Sbjct: 388  RSRIKQMTTQGEELREQKE---------KSERAAFEE-----------LEKALSTAQKTE 427

Query: 297  EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS-KDQMEKEMLEKIGRLEK--EL 353
            EA+        E++  + K + E   ++Q  L  V+Q   D M+K   E+I +L+K  E 
Sbjct: 428  EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK 487

Query: 354  ENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEK 413
            E A      TK+    L   E         A+ K     +K+++      E Q+ L LE+
Sbjct: 488  ELARKEQELTKK----LQTREREFQEQMKVALEKSQSEYLKISQ----EKEQQESLALEE 539

Query: 414  LENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ------- 466
            LE ++       I+ E E K   L+++ E Y   +  +  L   LE++++E +       
Sbjct: 540  LELQK-----KAILTESENKLRDLQQEAETY---RTRILELESSLEKSLQENKNQSKDLA 591

Query: 467  -RLQEDTDKANKQSSVL-ERDNRRMEI-----------QVKDLSQQIRVLLMELE---EA 510
              L+ + +K NK+ +V+ E+    +E            +++ L QQ +  + +L    E 
Sbjct: 592  VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651

Query: 511  RGNHVIRDEE-VSSADISSSSEVISQHL-VSYRNIEELQQQNQRLLVALRELGETREREE 568
                +++D+E +  A I   +E   + L V    +E L  +   +L A  +L E     +
Sbjct: 652  EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLK 711

Query: 569  QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPL 628
             +T   K  EL+ K++          + + H  Q VDSI+++ +    +  Q T  A+  
Sbjct: 712  DQTDKMK-QELEAKMD----------EQKNHHQQQVDSIIKEHE----VSIQRTEKALKD 756

Query: 629  HASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST-EAIEAKAALKQLQEIFENYKKEKA 687
              + L ++ L    K     Q         +  S  E  +A A L    ++F++Y+    
Sbjct: 757  QINQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL----DVFQSYQSATH 811

Query: 688  ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQ 747
            E  K   EQL +LQ+++ DL ++   ++ Q+     + + +   ++ ++ ++  L    Q
Sbjct: 812  EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL---MQ 868

Query: 748  KLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
            +L     + EQ + ++TQ          V E + E+  KE+E  K    ++  ++E+++ 
Sbjct: 869  QLEKQNSEMEQKVKSLTQ----------VYESKLEDGNKEQEQTK----QILVEKENMIL 914

Query: 808  EQR-GQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT 866
            + R GQ   +        IL +  +  +  +    E+ E +  + +KK+E   ++   + 
Sbjct: 915  QMREGQKKEIE-------ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967

Query: 867  RNLDVQLLDTKRQLDTE---TNLHLNTKE------LLKNAQKEIATLKQHLSNMEVQVAS 917
              L  +LLD + +L  E   T L L+ KE      +L+ AQ   A +   +S +E     
Sbjct: 968  ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027

Query: 918  QSSQRTGKGQPSNKEDVDDLVS-------------------QLRQTEEQVNDLKERLKTS 958
            Q    T      ++ +++D++S                   QL++ E++V +LK+++   
Sbjct: 1028 QIESLT----EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083

Query: 959  TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIE---VRLKESAEFQTQLEKKLMEVE--- 1012
                E+    +T L+E   K+     E+++ ++     +   A+ +T+L+  L ++E   
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143

Query: 1013 ----KEKQELQD---DKRRAIESMEQQLSELKKTLSSVQNEVQ---EALQRASTALSNEQ 1062
                KE   LQ+   + +   E  ++++SEL   L +   E Q    + ++++ +L ++ 
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203

Query: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
               +   E+  I ++   K + E +L A   E +  +  + + + S   H +  T K + 
Sbjct: 1204 LEFKKLSEELAIQLDICCK-KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262

Query: 1123 QLL--ECKAS--------WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
             LL   C  S          E +  L     +   + E+ E Q + +   IE L  +  A
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322

Query: 1173 SVKEGVQGPLNVSLSEEGKSQ--EQILEILRFIR-REKEIAETRFEVAQVESLRYRQRVE 1229
              KEG       S  E   +Q  +++ E +  +   ++E+ E + E++ +        V+
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382

Query: 1230 LLER-ELQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMN--------VVMETNKML 1279
            L     L E + ++++ R++  +   + + Q ++L  K +T++         V + +   
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442

Query: 1280 REEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
             E K++ +    Q Q  V++L++    L+  + E  EK   +   K+ L++  KR+    
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQ---LELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499

Query: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN-------- 1391
              +   +   + +E   L +E +  T RI +L + I +   EI   N  L N        
Sbjct: 1500 GEMEDDKSKMEKKE-SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558

Query: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI--------TQVKKIGRRYKT 1443
            ++ L+Q L +   ++  EK+   K+ + KI+ ++ +V ++         +++ +    K+
Sbjct: 1559 HKELVQKL-QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617

Query: 1444 QYEELKAQQDKVMETSAQSSGD---HQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
            + EELKA +D++   SA    +     EQ ++  + Q L +   + E   K  ES +  L
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677

Query: 1501 QKTLSEKETEARNLQEQTVQLQSELS------RLRQDLQDRTTQEEQLRQQITEK--EEK 1552
               L E+E E   L+E+   ++S  S      R  +++   T QEE   Q   +K  EEK
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737

Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISR 1612
                          ++ ++  LT E E+L QR G   Q+K+E       ++ QY+ R+ +
Sbjct: 1738 --------------ISVLQRNLT-EKEKLLQRVG---QEKEETVSSHFEMRCQYQERLIK 1779

Query: 1613 LER-ELREHQERHL--EQRDEPQEPSNK 1637
            LE  E ++H+++ +    ++E +E + K
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKK 1807



 Score =  219 bits (557), Expect = 3e-56
 Identities = 388/1815 (21%), Positives = 780/1815 (42%), Gaps = 250/1815 (13%)

Query: 14   LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVES----EQQYFEIEKRLSHSQERLV 69
            L  LP+ ++ + E F  ++  E DG     +   V++    +Q+    E  L   +E + 
Sbjct: 245  LKPLPQ-LEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303

Query: 70   NETRECQSLRLELEKLNNQLKALT---EKNKELEIAQDRNIAIQSQFTRTK-EELEAEKR 125
            +   +C  L  E E L  QL       EK K+L +A+   +  Q +  +   E+LE +K 
Sbjct: 304  SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 363

Query: 126  DLI-RTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS-----DVSVKYR 179
             +I  T  ++ + LE   E++ +L  ++K+  T   EL+ + ++ + +     + ++   
Sbjct: 364  MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423

Query: 180  EKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE-------------KGNEILELKCNL 226
            +K  E  ++L    +  + T  KT  +E ++L +E             K +E    K   
Sbjct: 424  QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483

Query: 227  ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK-------LKEAKEQQASME-EKFHNE 278
             ++KE   + +E    L+T     Q+ ++  L K       + + KEQQ S+  E+   +
Sbjct: 484  LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543

Query: 279  LNAHIKLS-NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
              A +  S N  +    ++E     +      L K L+E    +K +  HL   E  K++
Sbjct: 544  KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHL---EAEKNK 600

Query: 338  MEKEMLEKIGRLEKELENANDLLSAT-KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
              KE+   + + + ELE+      A    K  +L ++    M        +  +  +K  
Sbjct: 601  HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660

Query: 397  EL-YNAYVETQDQLLLEKLENKR-----INKYLDEIVK---EVEAKAPILKRQREEYERA 447
            E+ + A++E  ++  LEKL+ K+     ++  L E++K   ++E +  +LK Q ++ ++ 
Sbjct: 661  EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ- 719

Query: 448  QKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMEL 507
                  L  K+++     Q+  +   K ++ S       +R E  +KD   Q+ +LL E 
Sbjct: 720  -----ELEAKMDEQKNHHQQQVDSIIKEHEVSI------QRTEKALKDQINQLELLLKER 768

Query: 508  EEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE-LGETRER 566
            ++    H    E +  ADI  S   + Q        +  Q        A  E L + +++
Sbjct: 769  DKHLKEHQAHVENLE-ADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827

Query: 567  -----EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQT 621
                  E+   + ++ E++ + +   TEL+       H++Q+ D +++Q +     + Q 
Sbjct: 828  LLDLETERILLTKQVAEVEAQKKDVCTELDA------HKIQVQD-LMQQLEKQNSEMEQK 880

Query: 622  TGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA-------IEAKAALKQ 674
                  ++ S L+D +     K    ++ +       +++  E        +  K + K+
Sbjct: 881  VKSLTQVYESKLEDGN-----KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE 935

Query: 675  -----LQEIFEN-YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLD--------- 719
                 L E +E  +K ++ + EK++ +  E  +     L  Q  K+  +L+         
Sbjct: 936  DSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995

Query: 720  ---FASKRYEMLQDNVEGYRREITSLHERNQK-----LTATTQKQ--------EQIINTM 763
               F +K  EM Q N  G    ++ L E NQK     LT   +++        E+ +N  
Sbjct: 996  EKQFNAKMLEMAQANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ 1054

Query: 764  TQDLRGANE------KLAVAEVRA---------ENLKKEKEMLKLSEVR----LSQQRES 804
             ++L+  +E      +  VAE++          E + KE   LK   V+    L++ +E 
Sbjct: 1055 AEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQ 1114

Query: 805  LLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI-------------EKLEHEISHL 851
            L  +    N L  +   ++  LE+ E +  + L                 E+ + ++S L
Sbjct: 1115 LKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSEL 1174

Query: 852  KKKLENEVEQRHTL-------TRNLDVQLLDTKRQLDTETNLHLN-----TKELLKNAQK 899
              KL+   E+  +L        ++L+ + L+ K+ L  E  + L+     T+ LL+    
Sbjct: 1175 TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK-LSEELAIQLDICCKKTEALLEAKTN 1233

Query: 900  EIATLKQHLSNMEVQVASQSSQRTGKGQPS---NKEDVDDLVSQLRQTEEQVNDLKERLK 956
            E+  +    +N  +   S    RT K + +       V +L +QLRQ  E+ N L    +
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293

Query: 957  TSTSNVEQYQAMVTSLE---ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME--- 1010
             +T  +E+ +  + S++   ESL  EK+  ++   N +    E     TQL+K+L E   
Sbjct: 1294 QATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENIN 1353

Query: 1011 -VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQ 1069
             V   K+EL++ K+  I S+ +QL++L   L   QN +  + + A+ +   +Q     C+
Sbjct: 1354 AVTLMKEELKE-KKVEISSLSKQLTDLNVQL---QNSISLSEKEAAISSLRKQYDEEKCE 1409

Query: 1070 EQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                +  + Q+   +   L    + AL+   +  +K +  ++  +    + ++ + E + 
Sbjct: 1410 ----LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465

Query: 1130 SWEERERMLKDEVSKCVCRCEDLEKQNR---LLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
              E + +   ++  +     E+L++QN+    L  ++E   DK     KE        +L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME--DDKSKMEKKES-------NL 1516

Query: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESL--RYRQRVELLEREL-QELQDSLN 1243
              E KSQ       R +  E  I +   E+  +  +   Y Q+ ++  +EL Q+LQ    
Sbjct: 1517 ETELKSQTA-----RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE 1571

Query: 1244 AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELD 1303
               EK     +   +   L  +  +M   +ET K   +E E +   ++  + +++ LE D
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKK---KELEHVNLSVKSKEEELKALE-D 1627

Query: 1304 ILPLQEAN--AELSEKSGMLQA--EKKLL---EEDVKRWKARNQHLVSQQKDPDTEEYRK 1356
             L  + A   AEL  K+    A  +K+LL   EE  +++K   +  +S+      E  R+
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687

Query: 1357 --LLSEKEVHTKRIQQLTEEIGRLKAEIAR-SNASLTNNQNLIQSLKED----LNKVRTE 1409
              +L EK    +  Q  T  + R    +A  +     ++Q  +Q   E+    L +  TE
Sbjct: 1688 VHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE 1747

Query: 1410 KETIQKDLDAKIIDIQEKVKTITQVKKIGRRY-----KTQYEELKAQQDKVMETSAQSSG 1464
            KE + + +       QEK +T++   ++  +Y     K ++ E K  +D+ M    Q   
Sbjct: 1748 KEKLLQRVG------QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801

Query: 1465 DHQEQHVSVQEMQELKETLNQAETKSK-SLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
            + + +  S+   Q +++   +   ++K +LE+  +++QKTL EKE   + L+++  +L S
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861

Query: 1524 ELSRLRQ----DLQDRTTQEEQLR--QQITEKEEKTR--KAIVAAKSKIAHLAGVK--DQ 1573
             L R ++    ++++ T++ E+L+  QQ+  + + T   +     KSK +HL   K    
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSK-SHLVQPKLLSN 1920

Query: 1574 LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
            +  ++ +L+ +    +++K +L   I  L  Q + R+ R E +    QE  + +++  QE
Sbjct: 1921 MEAQHNDLEFKLAGAEREKQKLGKEIVRL--QKDLRMLRKEHQ----QELEILKKEYDQE 1974

Query: 1634 PSNKVPEQQRQITLK 1648
               K+ ++Q  + LK
Sbjct: 1975 REEKIKQEQEDLELK 1989



 Score =  211 bits (536), Expect = 9e-54
 Identities = 352/1693 (20%), Positives = 709/1693 (41%), Gaps = 250/1693 (14%)

Query: 5    LQQVLE--RTELNKLPKSVQNKLEKFL---ADQQSEIDGLKGRHEK-FKVESEQQYFEIE 58
            LQQ  E  RT + +L  S++  L++      D    ++  K +H K   V  E+   E+E
Sbjct: 558  LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617

Query: 59   KRLSHSQERLVNETREC--QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116
              L H Q+ L  E  +   Q  + E+EKL  +     E+ KE  + +D+ I  Q+     
Sbjct: 618  S-LKHQQDALWTEKLQVLKQQYQTEMEKLREKC----EQEKET-LLKDKEIIFQAHIEEM 671

Query: 117  KEELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDE--- 168
             E+   EK D+ +T  E LS EL  + +   +L E+L     +++  K EL+ K+DE   
Sbjct: 672  NEKT-LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730

Query: 169  ---------LQASDVSVKYREKRLEQE---KELLHSQNTWLNTELKTKTDELLALGREKG 216
                     ++  +VS++  EK L+ +    ELL  +      E +   + L A  +   
Sbjct: 731  HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790

Query: 217  NEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH 276
             E+ +    L+  +   S   EQ    +     LQ+ + DL T+     +Q A +E +  
Sbjct: 791  GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850

Query: 277  N---ELNAH-IKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
            +   EL+AH I++ +L +      E +++E+ + V+ L ++ +   E     Q+   ++ 
Sbjct: 851  DVCTELDAHKIQVQDLMQQL----EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL 906

Query: 333  QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
              K+ M  +M E     +KE+E     LSA +    IL+EE           + K+ +  
Sbjct: 907  VEKENMILQMREG---QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963

Query: 393  MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
             ++ E     +  Q+  L ++LEN      L+   KE +  A +L+  +        AV+
Sbjct: 964  KEMQETLKKKLLDQEAKLKKELENTA----LELSQKEKQFNAKMLEMAQANSAGISDAVS 1019

Query: 453  SLSVKLEQAMKEIQRL--QEDTD-------KANKQSSVLERDN----RRMEIQVKDLSQQ 499
             L    ++ ++ +  +  +E  D       K N+Q+  L+  +    +  E +V +L Q+
Sbjct: 1020 RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079

Query: 500  IRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE 559
            I +   E EE         EE    D ++ +E+  Q      ++  L Q   +L   L +
Sbjct: 1080 ILLFGCEKEEMNKEITWLKEEGVKQD-TTLNELQEQLKQKSAHVNSLAQDETKLKAHLEK 1138

Query: 560  LGETREREEQETT----------------SSKITELQLKLESALTELEQLRKSRQHQMQL 603
            L     +  +E T                  K++EL  KL++   E + L+ S +   + 
Sbjct: 1139 LEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198

Query: 604  VDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST 663
            ++     + +    LS+   + + +     + +  A T +  + S +             
Sbjct: 1199 LED----KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS------------- 1241

Query: 664  EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASK 723
               +  A L ++        K K E   I+   + +L+ Q+  L  +   ++     A+ 
Sbjct: 1242 ---KTNAILSRISHCQHRTTKVK-EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297

Query: 724  RYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT----MTQDLRGANEKLAVAEV 779
            + E  ++ ++  + +I SL    + L      Q+Q  +     +TQ  +  +E +    +
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357

Query: 780  RAENLKKEKEML-----KLSEVRLSQQRESLLAEQRGQNLLLTN---------LQTIQGI 825
              E LK++K  +     +L+++ +  Q    L+E+      L           L  +Q +
Sbjct: 1358 MKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDL 1417

Query: 826  LERSETETKQRLSS--QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQL-LDTKRQLDT 882
              + +T +K+++S+  Q++   ++ S  KKK ++   Q     + L +QL L +K   + 
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK 1477

Query: 883  ETNLHLNTKELLKNAQKEIATLKQHL-----------SNMEVQVASQSS----------Q 921
            +  ++L  KE L    K    LK  +           SN+E ++ SQ++          Q
Sbjct: 1478 DEQINL-LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536

Query: 922  RTGKGQPSNK--------EDVD--DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS 971
            +T + +  N+        +D++  +LV +L+  +E   +   R+K +   +   +  V S
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596

Query: 972  LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK----KLMEVE-KEKQELQDDKRRAI 1026
            ++  L  +K+  E V  +++ + +E    + +LE     KL E++ K +Q++   K++ +
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656

Query: 1027 ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
              ME++  + KK   S  +E+   LQ        E++      E+   +VE+    E  +
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQ--------EREREVHILEEKLKSVESSQS-ETLI 1707

Query: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV--SK 1144
            +  +A   A    +E+      V++  EE     +  L E K    +R    K+E   S 
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE-KEKLLQRVGQEKEETVSSH 1766

Query: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
               RC+  E+  +L H + ++  D       + + G L   L E+ K    I  + + + 
Sbjct: 1767 FEMRCQYQERLIKLEHAEAKQHED-------QSMIGHLQEELEEKNKKYSLI--VAQHVE 1817

Query: 1205 RE--------KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTM 1256
            +E        K+  E  F+  Q          ++LE++++EL   L  ++E  +V  + +
Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877

Query: 1257 AQHEELMKKTETMNVVMETNKMLREEKERLEQD-------LQQMQAKVRKLELDILPLQE 1309
                E ++  + M+   +  ++L E  E   +        L  M+A+   LE  +   + 
Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER 1937

Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE----VHT 1365
               +L ++   LQ + ++L       K   Q L   +K+ D E   K+  E+E     H 
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLR------KEHQQELEILKKEYDQEREEKIKQEQEDLELKHN 1991

Query: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQ 1425
              ++QL  E     A+           Q L  ++KE +NK +        +++A++++  
Sbjct: 1992 STLKQLMREFNTQLAQ---------KEQELEMTIKETINKAQ--------EVEAELLESH 2034

Query: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
            ++ +T   +KKI            A++D  ++ +A+            +E+ + +E   +
Sbjct: 2035 QE-ETNQLLKKI------------AEKDDDLKRTAKR----------YEEILDARE--EE 2069

Query: 1486 AETKSKSLESQVENLQKTLSEKETEARNLQEQTV---QLQSELSRLRQDLQDRTTQEEQL 1542
               K + L++Q+E LQK   +K  +  N     V   +LQ++L++    + D   +E++ 
Sbjct: 2070 MTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF 2129

Query: 1543 RQQITEKEEKTRK 1555
            R+QI   E++ +K
Sbjct: 2130 REQIHNLEDRLKK 2142



 Score =  189 bits (480), Expect = 3e-47
 Identities = 332/1558 (21%), Positives = 688/1558 (44%), Gaps = 191/1558 (12%)

Query: 119  ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
            ++++E  DL+  ++ L++E   L + ++R+   L        EL      LQ        
Sbjct: 119  DMDSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQ-------- 168

Query: 179  REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
            REK+ + +  L  SQ+  L    + + +EL    + K +   E   +LE K + +S L+ 
Sbjct: 169  REKK-KLQGILSQSQDKSLRRIAELR-EELQMDQQAKKHLQEEFDASLEEKDQYISVLQT 226

Query: 239  QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
            Q++ LK    +   +V D+L  L + + Q     E F  E N     S+      D +  
Sbjct: 227  QVSLLKQRLRNGPMNV-DVLKPLPQLEPQA----EVFTKEENPE---SDGEPVVEDGTSV 278

Query: 299  KSNE-LTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
            K+ E L + V+    LLK   E  ++ ++    +   K+ +++++ E++    +ELE   
Sbjct: 279  KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL----QELEKIK 334

Query: 358  DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP-GMKLTELYNAYVETQDQLLLEKLEN 416
            DL  A K K        +  +      + ++ +  GM + E      ET     LE  E 
Sbjct: 335  DLHMAEKTK-------LITQLRDAKNLIEQLEQDKGMVIAETKRQMHET-----LEMKEE 382

Query: 417  KRINKYLDEIVKEVEAKAPILKRQREEYERA-----QKAVASLSVKLEQAMKEIQRLQED 471
            +     L   +K++  +   L+ Q+E+ ERA     +KA+ S + K E+A ++++   ++
Sbjct: 383  EIAQ--LRSRIKQMTTQGEELREQKEKSERAAFEELEKAL-STAQKTEEARRKLKAEMDE 439

Query: 472  TDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE 531
              K  +++S  ER + + E     LS+  + ++  ++++    + + +++   +++   +
Sbjct: 440  QIKTIEKTSEEERISLQQE-----LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494

Query: 532  VISQHLVSYRNIEELQQQNQRLLVALRE-----LGETREREEQETTSSKITELQLKLESA 586
             +++ L +     E Q+Q   + VAL +     L  ++E+E+QE+ +  + EL+L+ ++ 
Sbjct: 495  ELTKKLQTRER--EFQEQ---MKVALEKSQSEYLKISQEKEQQESLA--LEELELQKKAI 547

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            LTE E   +  Q          ++ + YR  + +          SSL+     S  +  +
Sbjct: 548  LTESENKLRDLQ----------QEAETYRTRILELE--------SSLEK----SLQENKN 585

Query: 647  TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ----LEKLQE 702
             S+ ++             +EA+   K  +EI    +K K E E ++++Q     EKLQ 
Sbjct: 586  QSKDLAVH-----------LEAEKN-KHNKEITVMVEKHKTELESLKHQQDALWTEKLQV 633

Query: 703  QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN-QKLTATTQKQEQIIN 761
                 +++  K+  + +   ++  +L+D    ++  I  ++E+  +KL     + E + +
Sbjct: 634  LKQQYQTEMEKLREKCE--QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691

Query: 762  TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
             +++ L+  ++           L++E  +LK    ++ Q+ E+ + EQ+  +      Q 
Sbjct: 692  ELSEVLKARHK-----------LEEELSVLKDQTDKMKQELEAKMDEQKNHHQ-----QQ 735

Query: 822  IQGILERSETE---TKQRLSSQIEKLEHEISHLKKKLENE---VEQRHTLTRNLDVQLLD 875
            +  I++  E     T++ L  QI +LE  +    K L+     VE      +  + +L  
Sbjct: 736  VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQ 795

Query: 876  TKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVD 935
               +LD   +    T E  K  ++++A L+Q L ++E +    + Q   + +   K    
Sbjct: 796  ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ-VAEVEAQKK---- 850

Query: 936  DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL----NKEKQVTEEV---RK 988
            D+ ++L   + QV DL ++L+   S +EQ    +T + ES     NKE++ T+++   ++
Sbjct: 851  DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910

Query: 989  NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI-ESMEQQLSELKKTLSSVQNEV 1047
            N+ ++++E        +KK +E+  +K   ++D    + E  E +    +K +  V+ + 
Sbjct: 911  NMILQMREG-------QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963

Query: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM- 1106
            +E  +     L +++   +   E   + +  + K     ML  A   +     + VS++ 
Sbjct: 964  KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA-GISDAVSRLE 1022

Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
             + ++ +E  T+    +L +  + WE++     +E+ +      +++ Q +    ++ +L
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI----HEIQLQEK--EQEVAEL 1076

Query: 1167 SDKVVASVKEGVQGPLNVS-LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYR 1225
              K++    E  +    ++ L EEG  Q+  L  L+   ++K        +AQ E+ + +
Sbjct: 1077 KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN--SLAQDET-KLK 1133

Query: 1226 QRVELLERELQE-LQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
              +E LE +L + L+++   + + V++         ++ + T  +    E  + L+   E
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193

Query: 1285 RLEQDLQQMQAKVRKL------ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
            +  + L+    + +KL      +LDI   ++  A L  K+  L          +    + 
Sbjct: 1194 KSNKSLEDKSLEFKKLSEELAIQLDIC-CKKTEALLEAKTNELINISSSKTNAILSRISH 1252

Query: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
             QH  ++ K+    +    +SE E    +++QLTEE   L     ++   L   +N I+S
Sbjct: 1253 CQHRTTKVKEALLIK-TCTVSELEA---QLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308

Query: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK-IGRRYKT---QYEELKAQQDK 1454
            +K D+  + TEKE +QK+   +     EK   ITQ+KK +           EELK ++ +
Sbjct: 1309 MKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVE 1368

Query: 1455 VMETSAQSS--GDHQEQHVSVQEMQELKETLNQAETKSK-SLESQVENLQKTLSEKETEA 1511
            +   S Q +      +  +S+ E +    +L +   + K  L  QV++L   +     E 
Sbjct: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428

Query: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK 1571
             +  EQ     ++ S  ++  Q R TQ      Q T KE + +   +  KSK A+     
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQ-----HQNTVKELQIQ---LELKSKEAY--EKD 1478

Query: 1572 DQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
            +Q+    EEL Q+N   D  K E++      KS+ E + S LE EL+    R +E  D
Sbjct: 1479 EQINLLKEELDQQNKRFDCLKGEMEDD----KSKMEKKESNLETELKSQTARIMELED 1532



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 75/371 (20%), Positives = 164/371 (44%), Gaps = 44/371 (11%)

Query: 1291 QQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD 1350
            +Q+  ++R++E  +   +   +EL     MLQ EKK L           Q ++SQ +D  
Sbjct: 137  EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKL-----------QGILSQSQDKS 185

Query: 1351 TEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410
                 +L  E ++  +  + L EE           +ASL      I  L+  ++ ++   
Sbjct: 186  LRRIAELREELQMDQQAKKHLQEEF----------DASLEEKDQYISVLQTQVSLLKQRL 235

Query: 1411 ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ-SSGDHQEQ 1469
                 ++D         +K + Q++     + T+ E  ++  + V+E      + +  +Q
Sbjct: 236  RNGPMNVDV--------LKPLPQLEPQAEVF-TKEENPESDGEPVVEDGTSVKTLETLQQ 286

Query: 1470 HVSVQE--MQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
             V  QE  ++  KET+   + +   L S+ E LQ+ L E+  E   +++  +   +E ++
Sbjct: 287  RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM---AEKTK 343

Query: 1528 LRQDLQDRTTQEEQLRQQ----ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQ 1583
            L   L+D     EQL Q     I E + +  + +   + +IA L     Q+T + EEL++
Sbjct: 344  LITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 403

Query: 1584 RNGALDQQK-DELDVRITALKSQYEGR---ISRLERELREHQERHLEQRDEPQEPSNKVP 1639
            +    ++   +EL+  ++  +   E R    + ++ +++  ++   E+R   Q+  ++V 
Sbjct: 404  QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK 463

Query: 1640 EQQRQITLKTT 1650
            ++   +  K++
Sbjct: 464  QEVVDVMKKSS 474


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  239 bits (611), Expect = 2e-62
 Identities = 361/1726 (20%), Positives = 742/1726 (42%), Gaps = 244/1726 (14%)

Query: 20   SVQNKLEKFLADQQSEIDGLKGRHEKF---KVESEQQYFEIEKRLSHSQERLVNETRECQ 76
            S +N L+  +AD ++    L   +E     KV   QQ  ++E+       R+    +   
Sbjct: 582  SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641

Query: 77   SLRLELEKLNNQLKALTEKNKELEI----AQDRNIAIQSQFTRTKEELEAEKRDLIRTN- 131
            +L+++L +   + +AL EKN  LE     A++    +Q+     +EE E  ++ L  +  
Sbjct: 642  ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701

Query: 132  --ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189
              E  + +LE L ++ KR  E L  +   K  L  +   L+    +V+   + L ++ + 
Sbjct: 702  QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761

Query: 190  LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH 249
            L S    L + L     +   +   KG   LE++     + +EV + E +   L+   E 
Sbjct: 762  LSSAKELLESSLFEAQQQNSVIEVTKGQ--LEVQIQTVTQAKEVIQGEVRCLKLELDTER 819

Query: 250  LQKHVE-DLLTKL--------KEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
             Q   E D   +         K A EQQ +  EK  N+L    +     +S      AK+
Sbjct: 820  SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE---RSWHQQELAKA 876

Query: 301  NE-LTRAVEELHKLLKEAGEANKAIQ----DHLLEVEQSKDQMEKE-------MLEKIGR 348
             E L R   EL   LKE     +AIQ    +   + E +  QM+ E       +LE + +
Sbjct: 877  LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936

Query: 349  LEKELENANDLLSATKRKGAI--LSEEELAAMSPTAAAVAK--IVKPGMKLTELYNAYVE 404
             +KEL +A+  L   ++   +  L E+E   +  T    A+  + +   +  +   A  E
Sbjct: 937  TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996

Query: 405  TQDQLLLEKLE-NKRINKYLDEIVKE------VEAKAPILKRQREEYERAQKAV----AS 453
                LL +K++  K++     ++V +      VE +     R+ +EY R QK +    AS
Sbjct: 997  ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS 1056

Query: 454  LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
            L++ L +  + +  LQE      ++ S L +D +  + + K+LS Q+ +L  E++E   +
Sbjct: 1057 LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116

Query: 514  HVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS 573
             + ++ ++                     +EEL+  +         + E + R       
Sbjct: 1117 FLAQEAQL---------------------LEELEASH---------ITEQQLRASLWAQE 1146

Query: 574  SKITELQLKLESALTELEQLRKSRQ--HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHAS 631
            +K  +LQL+L S  ++LE L   +Q  +Q Q    +       +  L         L   
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206

Query: 632  SLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEK 691
                 S+       + ++++    P+    S EA+ A A  K  Q++++       +   
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV-ASALHKLHQDLWKTQ-----QTRD 1260

Query: 692  IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
            +  +Q++KL+E++TD  ++ +++ T+L              +  +R+++   E   K   
Sbjct: 1261 VLRDQVQKLEERLTDTEAEKSQVHTEL--------------QDLQRQLSQNQEEKSKWEG 1306

Query: 752  TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA---E 808
                 E  +  + + +     +L  AE++    + E+E+L+ ++  L+ Q E L A   E
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE 1366

Query: 809  QRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRN 868
             R Q        +  GILE      +  L     KL++E      ++E+E E+   L   
Sbjct: 1367 ARAQ-------ASAAGILEEDLRTARSAL-----KLKNE------EVESERERAQALQEQ 1408

Query: 869  LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQP 928
             ++++   K     + NL L T+ L +  ++E+ TL+  +  +E Q   Q          
Sbjct: 1409 GELKVAQGKA---LQENLALLTQTLAER-EEEVETLRGQIQELEKQREMQ---------- 1454

Query: 929  SNKEDVDDLVSQLRQTEEQVNDLKER---LKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
              K  ++ L   L++  ++V+  +E+   L+   S +E     V   E+ L  +++   E
Sbjct: 1455 --KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE 1512

Query: 986  VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI--ESMEQQLSELKKTLSSV 1043
            + K+ E +         +LEKK   +E ++ ++QD K++ +  E +  +L E    +   
Sbjct: 1513 LEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ 1572

Query: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV--------EA 1095
            Q  ++E   +  T          D +E+++  ++AQ+    +L  H+  +        + 
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQ-ELQAQSSQIHDLESHSTVLARELQERDQE 1631

Query: 1096 LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
            +++ +EQ+ ++   ++HL +  ++ + +L+  K    ER ++L+D+ ++          Q
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQK----ERIQVLEDQRTR----------Q 1677

Query: 1156 NRLLHDQIEKLSDKVVASVKE-GVQGPLNVSLSEEGK----SQEQILEILRFIRREKEIA 1210
             ++L + +E++   +    +E   Q  L    +EEGK    +Q   LE ++ I R+KE  
Sbjct: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE-- 1735

Query: 1211 ETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMN 1270
                           + VE  +  + ELQ+  +   +++Q   + + +   L+ + E   
Sbjct: 1736 ---------------KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780

Query: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
            VV++  + L+E +E+ E   Q +Q+++ + +  +    +    L ++    Q +++ ++E
Sbjct: 1781 VVLQ--QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838

Query: 1331 --DVKRWKARNQHLVSQQKDPDTEEY----RKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
              D  +      H+  +++  + +++    R+L  E  V  +R+Q L E +G L+AE   
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898

Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKD-LDAKIIDIQEKVKTITQVKKIGRRYKT 1443
               +L   Q   Q   E   +   E   +Q   L A+ + ++E+ + +  ++   +  + 
Sbjct: 1899 QEKALLALQ---QQCAEQAQEHEVETRALQDSWLQAQAV-LKERDQELEALRAESQSSRH 1954

Query: 1444 QYEELKAQQDKVMET--SAQSSGDHQEQHVSVQ---------EMQELKETLNQAETKSKS 1492
            Q E  +A+ + + E    A ++   +EQH+  Q             L+ +L+  +  S+ 
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014

Query: 1493 LES------------------QVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD 1534
            LE                    V+ LQ+ L++++ E R+ QE+   L+  L+   Q +Q+
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA---QRVQE 2071

Query: 1535 RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNG--ALDQQK 1592
               QE+Q   Q  E+EE+  + +  +  ++      K+Q   E  E +QRN   AL    
Sbjct: 2072 NMIQEKQNLGQ--EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129

Query: 1593 -----DELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
                 +E  +++ +L+ + +  + RL+  LR+ + R +E R++ Q+
Sbjct: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQD 2175



 Score =  228 bits (580), Expect = 7e-59
 Identities = 366/1739 (21%), Positives = 728/1739 (41%), Gaps = 255/1739 (14%)

Query: 24   KLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELE 83
            +LEK   ++  E+  LK + +  K E + +  E+   L+ SQ++  +  +  ++LR  +E
Sbjct: 255  ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314

Query: 84   KLNNQLKALTEKNKELEI-AQDRNIAIQSQFTRTKEELEAEKRDLI----------RTNE 132
             L      L E    L   AQ+  +++Q Q  +   ++  E+ D I            + 
Sbjct: 315  ILETNHTELMEHEASLSRNAQEEKLSLQ-QVIKDITQVMVEEGDNIAQGSGHENSLELDS 373

Query: 133  RLSQELEYLTED----------------VKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
             +  + +Y   D                V+ L ++L         LQ + D+ +    ++
Sbjct: 374  SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433

Query: 177  KYREKRLEQEKELLHSQNTWLNTELKT--KTDELLALGREKGNEILEL---------KCN 225
            + R ++L  E++ L  Q   L  E+ +  K  ELL   RE+  + LE+         + N
Sbjct: 434  RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN 493

Query: 226  LE---------NKKEEVS-----------RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAK 265
            +E          +KEE             RL+E + GL+       + + +L+T L+EA 
Sbjct: 494  VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS---ESLSELIT-LREAL 549

Query: 266  EQQASMEEKFHNE-LNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI 324
            E      E    E       L+   +S A+ S ++ N L   V +L     +    N+A+
Sbjct: 550  ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEAL 608

Query: 325  QDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN----DLLSATKRKGAILSEEELAAMSP 380
                + + Q   Q+E+E      R+E   +  N    DL  A KR+ A+  +      + 
Sbjct: 609  ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN-----TH 663

Query: 381  TAAAVAKIVKPGMKLT----ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPI 436
              A + K  + G +L     ++     E Q +L   + + +     L+++ +E + +  +
Sbjct: 664  LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723

Query: 437  LKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD--------------KANKQSSVL 482
            L R  +E E   +  A+L V+L+   ++ Q L E                 +A +Q+SV+
Sbjct: 724  LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783

Query: 483  ERDNRRMEIQVKDLSQ-------QIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQ 535
            E    ++E+Q++ ++Q       ++R L +EL+  R +   ++ + ++  ++ + +    
Sbjct: 784  EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTER-SQAEQERDAAARQLAQAEQEGKT 842

Query: 536  HLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRK 595
             L   +   E            +E+ + RE+ E+E +  +  EL   LES   E  +L  
Sbjct: 843  ALEQQKAAHE------------KEVNQLREKWEKERSWHQ-QELAKALESLEREKMELEM 889

Query: 596  SRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPA 655
              + Q   +++I  QR+  R               S+L  + L +  +R S  +T+    
Sbjct: 890  RLKEQQTEMEAIQAQREEERTQAE-----------SALCQMQLETEKERVSLLETL---- 934

Query: 656  PVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKIS 715
               +    E  +A   L++L++  +  K ++ E   I   QL++ Q ++ +   Q+    
Sbjct: 935  ---LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDL 991

Query: 716  TQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLA 775
              L   S    +LQD ++  ++    + +   +L A    Q  +   + + LR   E   
Sbjct: 992  AALQEESS--SLLQDKMDLQKQ----VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045

Query: 776  VAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
            + +     L++EK  L LS   L ++ + LL  Q   ++    L  ++  ++ ++ E K+
Sbjct: 1046 IQK----ELEREKASLTLS---LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098

Query: 836  RLSSQIEKLEHEISHLKK-------KLENEVEQRHTLTRNLDVQLLDTK--------RQL 880
             LS+Q+E L  E+   +        +L  E+E  H   + L   L   +        R  
Sbjct: 1099 -LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLR 1157

Query: 881  DTETNLHLNTKELLKN----AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
             TE+ L     E        AQ ++A+L   L      V     + +G G      D   
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGG------DSAP 1211

Query: 937  LVSQLRQTEEQVNDLKERLKTSTS-NVEQYQAMVTSLEESLNKEKQVTEEVR---KNIEV 992
             V  L   +     L +R    T+ + E   + +  L + L K +Q  + +R   + +E 
Sbjct: 1212 SVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEE 1271

Query: 993  RLKESAEFQTQLEKKLMEVEKEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQE 1049
            RL ++   ++Q+  +L +++++  + Q++K +      S+E +L EL +T++S+Q+ ++ 
Sbjct: 1272 RLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRR 1331

Query: 1050 A-LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS 1108
            A LQR       E Q  R+  + AK  + AQ             VE LQAA  +    AS
Sbjct: 1332 AELQRM------EAQGERELLQAAKENLTAQ-------------VEHLQAAVVEARAQAS 1372

Query: 1109 VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168
                LEE  + A S L           ++  +EV     R + L++Q  L   Q + L +
Sbjct: 1373 AAGILEEDLRTARSAL-----------KLKNEEVESERERAQALQEQGELKVAQGKALQE 1421

Query: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRV 1228
             +           L  +L+E  +  E +   ++ + +++E+ +   E+  ++  +  Q V
Sbjct: 1422 NLAL---------LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472

Query: 1229 ELLERELQELQDSLN-------AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLRE 1281
            +L + ++QEL+   +       A +E+ Q       Q  EL K  ET   V+E   +   
Sbjct: 1473 DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--- 1529

Query: 1282 EKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQH 1341
            E E+ +Q ++  + +V+ L+  ++ L+    EL E    ++ ++KL++E           
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE----------- 1578

Query: 1342 LVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKE 1401
             +  Q++        L  + E  ++ +Q  + +I  L++        L      ++S +E
Sbjct: 1579 -LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637

Query: 1402 DLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ 1461
             + +++ +KE + +DL+ +  ++  + + I QV +  R  +T+  E   +Q K+   S +
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRTRQTKILEEDLEQIKL---SLR 1693

Query: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQL 1521
              G  +E     Q MQE  E   + +  SK+    +E+++  L +KE E    QE   +L
Sbjct: 1694 ERG--RELTTQRQLMQERAE---EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHEL 1748

Query: 1522 QSELSRLRQDLQ-------DRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q    +L Q LQ       + +    Q  Q+I   +++ ++A    + K   L    D+ 
Sbjct: 1749 QELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
             +   +  Q   AL Q++ +   +   +K + +     LE+     +ERH E +D  ++
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ 1867



 Score =  188 bits (478), Expect = 5e-47
 Identities = 324/1589 (20%), Positives = 653/1589 (41%), Gaps = 218/1589 (13%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESE----QQYFEIEKR 60
            L + LE  E  K+      +LE  L +QQ+E++ ++ + E+ + ++E    Q   E EK 
Sbjct: 873  LAKALESLEREKM------ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926

Query: 61   LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
                 E L+   +E      +LE+L   +K   +K KE    Q+    +Q+Q    + EL
Sbjct: 927  RVSLLETLLQTQKELADASQQLERLRQDMKV--QKLKE----QETTGILQTQLQEAQREL 980

Query: 121  EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
            +   R        L +E   L +D              K +LQ ++++L++  V+    +
Sbjct: 981  KEAARQHRDDLAALQEESSSLLQD--------------KMDLQKQVEDLKSQLVAQDDSQ 1026

Query: 181  KRLEQE-KELLHSQNTW--LNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237
            + +EQE +E L     +  +  EL+ +   L     EK   +L L+     +++E+S L 
Sbjct: 1027 RLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR 1086

Query: 238  EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
            + M   +   + L   +E L  ++KE +    + E +   EL A        +++    E
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146

Query: 298  AKSNELT---RAVE-ELHKLLKEAGEANKA------------IQDHLLEVEQSKDQMEK- 340
            AK+ +L    R+ E +L  L  E    N+A            +Q  L  V +S+ ++   
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             +    +  LE +   A  L     ++G +L+     A+   A+A+ K+ +   K T+  
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLF----KRGPLLTALSAEAV---ASALHKLHQDLWK-TQQT 1258

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLE 459
               +  Q Q L E+L +    K   ++  E++     L + +EE  + +    SL  +L 
Sbjct: 1259 RDVLRDQVQKLEERLTDTEAEK--SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM 1316

Query: 460  QAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE 519
            +  + +  LQ    +A  Q    + +   ++   ++L+ Q+  L   + EAR        
Sbjct: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA------- 1369

Query: 520  EVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITEL 579
            + S+A I       ++  +  +N EE++ + +R   AL+E GE +  +        + E 
Sbjct: 1370 QASAAGILEEDLRTARSALKLKN-EEVESERERAQ-ALQEQGELKVAQ-----GKALQEN 1422

Query: 580  QLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639
               L   L E E+  ++ + Q+Q ++   +QR+M +  L              L  + L 
Sbjct: 1423 LALLTQTLAEREEEVETLRGQIQELE---KQREMQKAALE-------------LLSLDLK 1466

Query: 640  STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699
               +     Q                 E    L++ + + E+      E E+    Q E+
Sbjct: 1467 KRNQEVDLQQ-----------------EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509

Query: 700  LQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759
            ++E   D  +Q   +  QL    K+ +M    +E  R ++  L           +KQ   
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQM----IESQRGQVQDL-----------KKQLVT 1554

Query: 760  INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
            +  +  +L   + K+   +   + L+ ++E  +++   L+   E    E + Q+  + +L
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614

Query: 820  QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQR--HTLTRNLDVQLLDTK 877
            ++   +L R   E  Q + SQ E++E E+   K+ L  ++E+R    + +   +Q+L+ +
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIE-ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673

Query: 878  RQLDT---ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKG-QPSNKED 933
            R   T   E +L    K  L+   +E+ T +Q +         Q     GKG   + +  
Sbjct: 1674 RTRQTKILEEDLE-QIKLSLRERGRELTTQRQLM---------QERAEEGKGPSKAQRGS 1723

Query: 934  VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
            ++ +   LR  E++V   +E       ++ + Q +   LE+ L           + +  +
Sbjct: 1724 LEHMKLILRDKEKEVECQQE-------HIHELQELKDQLEQQL-----------QGLHRK 1765

Query: 994  LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
            + E++   +Q E++++ ++++ QE ++      +S++ QL E ++ L+    E++     
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE----- 1820

Query: 1054 ASTALSNEQQARRDCQEQAKIAVEA-QNKYERELMLHAADVEALQAAKEQVSKMASVRQH 1112
               AL  EQQ  +  +E+ K   +A Q   E+  M        LQ  KEQ  ++      
Sbjct: 1821 ---ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877

Query: 1113 LEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHD----------- 1161
                 Q  E  L + +A   E+E+ L     +C  + ++ E + R L D           
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE 1937

Query: 1162 ------------QIEKLSDKVVASVKEGVQGPL-NVSLSEEGKSQEQI--LEILRFIRRE 1206
                        Q  +  ++   +  E +Q  L     + +GK Q  +   E+ R +   
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997

Query: 1207 KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT 1266
                +   +  Q  S   RQ  E L  +  E+QD     +E VQ   + +AQ +E ++  
Sbjct: 1998 TATLQASLDACQAHS---RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054

Query: 1267 ETMNVVMETN-------KMLREE----KERLEQDLQQMQAKVRKLELDILPLQEANAELS 1315
            +    ++E +        M++E+    +ER E++++ +   VR+L+L +   ++   EL 
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114

Query: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE-EYRKLLSEKEVHTKRIQQLTEE 1374
            E       E   L    K      Q L     +P  + E  +L +       R  +  E+
Sbjct: 2115 ETQQRNNLE--ALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREK 2172

Query: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK---VKTI 1431
               L   +A++ AS+++ Q +   L+  + +  +E++ +Q +L+     ++++       
Sbjct: 2173 AQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGA 2232

Query: 1432 TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK 1491
            T   ++G R      E   Q  +V    A+ S D  E+    Q ++ L++ + + E    
Sbjct: 2233 TSTAELGSR-----GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS 2287

Query: 1492 SLESQVENLQKTLSEKETEARNLQEQTVQ 1520
             L+     L+ TL + E E R L+ + ++
Sbjct: 2288 RLQRHNVQLRSTLEQVERERRKLKREAMR 2316



 Score =  165 bits (418), Expect = 4e-40
 Identities = 330/1587 (20%), Positives = 630/1587 (39%), Gaps = 240/1587 (15%)

Query: 151  KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS----QNTWLNTELKTKTD 206
            KLK S   +      + +LQA    ++YR    E EK L  +       W N E +   D
Sbjct: 41   KLKNSQEAQQRQATLVRKLQAK--VLQYRSWCQELEKRLEATGGPIPQRWENVE-EPNLD 97

Query: 207  ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
            ELL    E+     + +C  E+  E  ++L   M      N+ L++ VE L      A++
Sbjct: 98   ELLVRLEEE-----QQRC--ESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARD 150

Query: 267  QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
            +    E ++  E          +K        +   L R V    +              
Sbjct: 151  ELMRKESQWQME-------QEFFKGYLKGEHGRLLSLWREVVTFRR-------------- 189

Query: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386
            H LE++ + D+   E+  +  RL   L     L    +      S E   +        A
Sbjct: 190  HFLEMKSATDRDLMELKAEHVRLSGSL-----LTCCLRLTVGAQSREPNGSGRMDGREPA 244

Query: 387  KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446
            +++    K  EL     E   +L+  K +       L + V E+ A     ++Q E+YE+
Sbjct: 245  QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304

Query: 447  AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLME 506
              KA+           + ++ L+ +  +  +  + L R+ +  ++ ++ + + I  +++E
Sbjct: 305  MIKALR----------ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVE 354

Query: 507  LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER 566
                 G+++ +     ++ +   S + SQ         + Q  ++ L +    L  TR R
Sbjct: 355  ----EGDNIAQGSGHENS-LELDSSIFSQF--------DYQDADKALTLVRSVL--TRRR 399

Query: 567  EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAI 626
            +  +    ++   Q        E   L + +  Q +     +RQR      L + TG   
Sbjct: 400  QAVQDLRQQLAGCQ--------EAVNLLQQQHDQWEEEGKALRQR------LQKLTGERD 445

Query: 627  PLHASSLD---DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ---EIFE 680
             L   ++D   +V   S  +             + V+E  EA   +    +LQ   +  +
Sbjct: 446  TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ-EAWRLRRVNVELQLQGDSAQ 504

Query: 681  NYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGY----- 735
              K+E+ E   +   + E+LQE +  L ++ ++  ++L   + R  +   ++EG      
Sbjct: 505  GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL--ITLREALESSHLEGELLRQE 562

Query: 736  RREITSLHERNQKLTATTQKQEQIINTMTQDLRGA-------NEKLAVAEV--------- 779
            + E+T+   R ++  A     E  + T   DLR A       NE LA+ +V         
Sbjct: 563  QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622

Query: 780  RAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSS 839
              EN      M    + R + Q +   AE+R + L   N   ++  L+++E E    L +
Sbjct: 623  EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH-LEAQLQKAE-EAGAELQA 680

Query: 840  QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQK 899
             +  ++ E   ++KKL     Q+   T  L+    + KRQ           +E+L  A +
Sbjct: 681  DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ-----------EEVLARAVQ 729

Query: 900  EIATLKQHLSNMEVQVASQSSQRTG-----KGQPSNKEDVDDLVSQLRQTEEQVN----D 950
            E   L +  + +EV++ +    R       +G  S KE ++  + + +Q    +      
Sbjct: 730  EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789

Query: 951  LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA-EFQTQLEKKLM 1009
            L+ +++T T   E  Q  V  L+  L+ E+   E+ R     +L ++  E +T LE++  
Sbjct: 790  LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA 849

Query: 1010 EVEKEKQEL-----------QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
              EKE  +L           Q +  +A+ES+E++  EL+  L   Q E+ EA+Q A    
Sbjct: 850  AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM-EAIQ-AQREE 907

Query: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQ 1118
               Q     CQ Q +   E  +  E  L       +A Q  +     M   +   +ETT 
Sbjct: 908  ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG 967

Query: 1119 KAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGV 1178
              ++QL E +   +E  R  +D+++        L +    L  Q+E L  ++VA      
Sbjct: 968  ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA------ 1021

Query: 1179 QGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQEL 1238
                      +  SQ  +         E+E+ E          LR  Q    +++EL   
Sbjct: 1022 ----------QDDSQRLV---------EQEVQE---------KLRETQEYNRIQKEL--- 1050

Query: 1239 QDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVR 1298
                  EREK  +T         LM+K + + V+ E + + ++E   L QD+Q+ Q + +
Sbjct: 1051 ------EREKASLTLS-------LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS----QQKDPDTEEY 1354
            +L   +  L++   E+ EK     A++  L E+++      Q L +    Q+      + 
Sbjct: 1098 ELSAQMELLRQ---EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154

Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLT-----------------NNQNLIQ 1397
            R   +E ++     +Q      + +A++A   ++L                  ++   + 
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVW 1214

Query: 1398 SLKEDLNKVRT--EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKV 1455
             L+ D N  R+  ++  +   L A+ +      K    + K  +      ++++  ++++
Sbjct: 1215 GLEPDQNGARSLFKRGPLLTALSAEAV-ASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273

Query: 1456 METSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ 1515
             +T A+ S  H E     +++ + +E  ++ E K  SLES++  L +T++  ++  R  +
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333

Query: 1516 EQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK----------EEKTRKAIVAAKSKIA 1565
             Q ++ Q E   L+   ++ T Q E L+  + E           EE  R A  A K K  
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393

Query: 1566 HLAGVKD--QLTKENEELKQRNGALDQQKDELDVRITALKSQ----YEGRISRLERELRE 1619
             +   ++  Q  +E  ELK   G   Q+   L  +  A + +      G+I  LE++ RE
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ-RE 1452

Query: 1620 HQERHLEQRD-EPQEPSNKVPEQQRQI 1645
             Q+  LE    + ++ + +V  QQ QI
Sbjct: 1453 MQKAALELLSLDLKKRNQEVDLQQEQI 1479



 Score =  148 bits (373), Expect = 7e-35
 Identities = 304/1407 (21%), Positives = 585/1407 (41%), Gaps = 185/1407 (13%)

Query: 430  VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ----RLQEDTDKANKQSSVLERD 485
            +E ++P L   + +    Q  +    + L+Q M E Q    R  +++ +A ++ + L R 
Sbjct: 1    METRSPGLNNMKPQ--SLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRK 58

Query: 486  NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545
             +   +Q +   Q++      LE   G    R E V   ++    E++ +     +  E 
Sbjct: 59   LQAKVLQYRSWCQELE---KRLEATGGPIPQRWENVEEPNLD---ELLVRLEEEQQRCES 112

Query: 546  LQQQNQRLLVALRELGET----REREEQETTSSKITELQLKLESALTELEQ------LRK 595
            L + N +L + + +        RE  E+ T        +L  + +  ++EQ      L+ 
Sbjct: 113  LAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172

Query: 596  SRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD-DVSLASTPKRPSTSQTVSTP 654
                 + L   +V  R  +  + S T    + L A  +    SL +   R +       P
Sbjct: 173  EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP 232

Query: 655  APVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNE-QLEK--LQEQVTDLRSQN 711
                 ++  E  +    L + QE+ +   +   E  +++++  LEK  LQ++VT+L +  
Sbjct: 233  NGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALL 292

Query: 712  TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQ----EQIINTMTQDL 767
            T+   Q +   K  + L++ VE      T L E    L+   Q++    +Q+I  +TQ +
Sbjct: 293  TQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVM 352

Query: 768  RGANEKLAVAEVRAENLKKEKEMLK----------LSEVR---------LSQQRESLLAE 808
                + +A       +L+ +  +            L+ VR         +   R+ L   
Sbjct: 353  VEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGC 412

Query: 809  QRGQNLLLTN----LQTIQGILERSETETKQR--LSSQIEKLEHEISHLKKKLENEVEQR 862
            Q   NLL        +  + + +R +  T +R  L+ Q   L+ E+  L K+ E   + R
Sbjct: 413  QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472

Query: 863  HTLTRNLDVQLLDTKRQLDTETNLHL----------NTKELLKNAQKEIATLKQHLSNME 912
              L + L+V   +  R       L L            +E L  A +E   L++ L  +E
Sbjct: 473  EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532

Query: 913  ------------VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
                        ++ A +SS   G+     + +V   +++  Q+  +++  +  LKT  +
Sbjct: 533  AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592

Query: 961  NVEQYQAMVTSLEES-------LNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEK 1013
            ++      +++L E+       LN++    EE  +++  R++ + + +  L+  L E EK
Sbjct: 593  DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK 652

Query: 1014 EKQELQDDK---RRAIESMEQQLSELKKTLSSVQNEVQEALQRAS-------TALSNEQQ 1063
             ++ L +        ++  E+  +EL+  L  +Q E +E  ++ S        A +  +Q
Sbjct: 653  RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ 712

Query: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK-------EQVSKMASVRQHLEET 1116
              ++ + Q ++   A  + E  +   AA    LQA +       EQ+  ++S ++ LE +
Sbjct: 713  LHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772

Query: 1117 TQKAESQLLECKASWEERERMLK-----DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVV 1171
              +A+ Q    + +  + E  ++      EV +   RC  LE        Q E+  D   
Sbjct: 773  LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE--RSQAEQERDAAA 830

Query: 1172 ASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQ-VESL-RYRQRVE 1229
              + +  Q     +L ++  + E+ +  LR  + EKE +  + E+A+ +ESL R +  +E
Sbjct: 831  RQLAQAEQEG-KTALEQQKAAHEKEVNQLR-EKWEKERSWHQQELAKALESLEREKMELE 888

Query: 1230 LLERELQELQDSLNAEREKVQVTAKT---MAQHEELMKKTETMNVVMETNKMLREEKERL 1286
            +  +E Q   +++ A+RE+ +  A++     Q E   ++   +  +++T K L +  ++L
Sbjct: 889  MRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL 948

Query: 1287 EQDLQQMQAKVRKLE----LDIL--PLQEANAELSEKS-------GMLQAEKKLLEEDVK 1333
            E+  Q M  KV+KL+      IL   LQEA  EL E +         LQ E   L +D  
Sbjct: 949  ERLRQDM--KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006

Query: 1334 RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQ 1393
              + + + L SQ    D  +    L E+EV  K  +  T+E  R++ E+ R  ASLT   
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQ---RLVEQEVQEKLRE--TQEYNRIQKELEREKASLT--- 1058

Query: 1394 NLIQSLKEDLNKVRTEKETI-QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQ 1452
             L    KE    V  E ++I Q++L A   D+QE      + K++  + +   +E+K ++
Sbjct: 1059 -LSLMEKEQRLLVLQEADSIRQQELSALRQDMQE---AQGEQKELSAQMELLRQEVKEKE 1114

Query: 1453 DKVMETSAQSSGDHQEQHVSVQEM------QELKETLNQAETKSKSLESQVENLQKTLSE 1506
               +   AQ   + +  H++ Q++      QE K    Q + + +S ESQ+E L      
Sbjct: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA--QLQLRLRSTESQLEAL-----A 1167

Query: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLR--------------QQITEKEEK 1552
             E +  N  +   QL S  S L+Q L        +L                Q   +   
Sbjct: 1168 AEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLF 1227

Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT---ALKSQYEGR 1609
             R  ++ A S  A +A    +L ++  + +Q    L  Q  +L+ R+T   A KSQ    
Sbjct: 1228 KRGPLLTALSAEA-VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE 1286

Query: 1610 ISRLERELREHQERHLE----------QRDEPQEPSNKVPEQQRQITLKTTPASGERG-I 1658
            +  L+R+L ++QE   +          +  E  E    +  + R+  L+   A GER  +
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL 1346

Query: 1659 ASTSDPPTANIKPTPVVSTPSKVTAAA 1685
             +  +  TA ++        ++  A+A
Sbjct: 1347 QAAKENLTAQVEHLQAAVVEARAQASA 1373



 Score =  138 bits (347), Expect = 7e-32
 Identities = 256/1260 (20%), Positives = 514/1260 (40%), Gaps = 166/1260 (13%)

Query: 5    LQQVLERTELNKLPKSVQ-NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSH 63
            L++ L  TE  K     +   L++ L+  Q E    +G+        E +  E+ + ++ 
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL----ESELMELHETMAS 1324

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAE 123
             Q RL     +    + E E L    + LT + + L+ A     A  S     +E+L   
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384

Query: 124  KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE-LQASDVSVKYREKR 182
            +  L   NE +  E     E  + L E        +GEL++   + LQ +   +      
Sbjct: 1385 RSALKLKNEEVESE----RERAQALQE--------QGELKVAQGKALQENLALLTQTLAE 1432

Query: 183  LEQEKELLHSQNTWL--NTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
             E+E E L  Q   L    E++    ELL+L  +K N+ ++L      ++E++  LE+  
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL------QQEQIQELEKCR 1486

Query: 241  NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
            + L    EHL   V++   KL   +EQ   +E+                     D E + 
Sbjct: 1487 SVL----EHLPMAVQEREQKLTVQREQIRELEK---------------------DRETQR 1521

Query: 301  NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
            N L   + EL K            +D ++E ++ + Q  K+ L  +  L  ELE  +  +
Sbjct: 1522 NVLEHQLLELEK------------KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569

Query: 361  SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
               ++   ++ E E    +   A           LT L     E   +L  +  +   + 
Sbjct: 1570 ECQQK---LIKELEGQRETQRVA-----------LTHLTLDLEERSQELQAQSSQIHDLE 1615

Query: 421  KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI----QRLQEDTDKAN 476
             +   + +E++ +   +K QRE+ E  Q+    L+  LE+  +E+    +R+Q   D+  
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675

Query: 477  KQSSVLERDNRRMEIQV----KDLSQQIRVLLMELEEARG------------NHVIRDEE 520
            +Q+ +LE D  ++++ +    ++L+ Q +++    EE +G              ++RD+E
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735

Query: 521  VSSA-------DISSSSEVISQHLVS-YRNIEE----LQQQNQRLLVALRELGETREREE 568
                       ++    + + Q L   +R + E    L Q+ Q ++V  ++L E RE+ E
Sbjct: 1736 KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE 1795

Query: 569  --QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAI 626
              +++  S++ E Q  L     ELE L++ +Q      + +  + D  +  L Q      
Sbjct: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855

Query: 627  PLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA---IEAKAALKQLQEIFENYK 683
              H    D    A   +     +     A   V+    A    + KA L   Q+  E  +
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915

Query: 684  KEKAENEKIQNEQLE------KLQEQVTDLRSQNTKISTQLDFASKRYEMLQD------- 730
            + + E   +Q+  L+      +  +++  LR+++     Q + A  R E LQ+       
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975

Query: 731  NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV--AEVRAENLKKEK 788
             ++G  + +    E ++ L A+T   +  ++      R   E L +   E++ ++L+ ++
Sbjct: 1976 ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE 2035

Query: 789  EMLKL--------SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840
            ++ +L         E+R  Q+RE LL +   Q +    +Q  Q + +  E E  + L   
Sbjct: 2036 DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQS 2095

Query: 841  IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
            + +L+  ++  ++++   +E R T  RN +++ L    +        L    L    Q+E
Sbjct: 2096 VRELQLTLAQKEQEI---LELRETQQRN-NLEALPHSHKTSPMEEQSLKLDSLEPRLQRE 2151

Query: 901  IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
            +  L+  L   E +            +   +E   DL   L QT+  V+ L+E      +
Sbjct: 2152 LERLQAALRQTEAR------------EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQA 2199

Query: 961  NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK--KLMEVEKEKQEL 1018
            +V +  +    L++ L   ++  E+ R +       +AE  ++ E+  +L EV   + E 
Sbjct: 2200 SVLERDSEQQRLQDELELTRRALEKERLH-SPGATSTAELGSRGEQGVQLGEVSGVEAEP 2258

Query: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL-SNEQQARRDCQEQAKIAVE 1077
              D     +S  Q+L  L++ ++ ++ + +  LQR +  L S  +Q  R+ ++  + A+ 
Sbjct: 2259 SPDGMEK-QSWRQRLEHLQQAVARLEID-RSRLQRHNVQLRSTLEQVERERRKLKREAMR 2316

Query: 1078 AQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
            A      E+    A     Q  + Q +  A     L++     E  LL+ + + E +++ 
Sbjct: 2317 AAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQK-----EVVLLQAQLTLERKQK- 2370

Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
             +D +++      +L   +  L   +  ++    A+V E     L+ SL++   S   +L
Sbjct: 2371 -QDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL 2429


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  237 bits (605), Expect = 9e-62
 Identities = 345/1721 (20%), Positives = 759/1721 (44%), Gaps = 254/1721 (14%)

Query: 9    LERTELNKLPKSV-QNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ-E 66
            L   E N   K + Q  +E  L   +++ D L   +E+ + E E+   +++++    + E
Sbjct: 479  LSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFE 538

Query: 67   RLVNETRECQSLRL--ELEKLNNQLKALTEKNKELEIAQDRNIAI----QSQFTRTKEEL 120
             L  +T++ Q ++L  E+  L N +K     N++LE      + +    + Q  + +E +
Sbjct: 539  ALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI 598

Query: 121  EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
            +++K + I+ +  LS  LE + ED K++ + L ++ T   + + +   L++ ++ +K + 
Sbjct: 599  DSQKLENIKMD--LSYSLESI-EDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKM 655

Query: 181  KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
            K L    + + +      ++L+ K    + L +E           L++   E+++L   +
Sbjct: 656  KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE-----------LQSAFNEITKLTSLI 704

Query: 241  NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
            +G    +      +E  +T L++   ++    E    E+   I LS L KS   + E   
Sbjct: 705  DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV---ILLSEL-KSLPSEVERLR 760

Query: 301  NELTRAVEELH-------KLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
             E+    EELH       KL  E       +Q  L E+ ++KD +           ++E 
Sbjct: 761  KEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQ-SNYKSTDQEF 819

Query: 354  ENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEK 413
            +N   L    ++K  ++ EE           +  + K   K      A ++T+     ++
Sbjct: 820  QNFKTLHMDFEQKYKMVLEEN----ERMNQEIVNLSKEAQKFDSSLGA-LKTELSYKTQE 874

Query: 414  LENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD 473
            L+ K   + + E + E+E     L+ +    +  ++    ++ KL+Q ++E++ L ++ D
Sbjct: 875  LQEK--TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932

Query: 474  --KANKQSSVLERDNRRMEIQVK-----DLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
              K  ++S  +ERD  + +I        D  +Q+R  L  L++         +E  +   
Sbjct: 933  DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ--------HQETINTLK 984

Query: 527  SSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS----SKITELQLK 582
            S  SE +S++L    N  E + + Q+ +V + +  +   +  Q  T+    ++I E Q K
Sbjct: 985  SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044

Query: 583  LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP 642
            + S + E  +L+       Q+++S++ +++  +  L +   + I     + +++ L    
Sbjct: 1045 IFSLIQEKNELQ-------QMLESVIAEKEQLKTDLKENIEMTI----ENQEELRLLGDE 1093

Query: 643  KRPSTSQTVSTPAPVPVIESTEAIEAKAALKQ----LQEIFENYKKEKAENEKIQNEQLE 698
             +            +   E   AI+ +  L +    L E+ E  K EK++  + + +QL 
Sbjct: 1094 LKKQQE--------IVAQEKNHAIKKEGELSRTCDRLAEVEEKLK-EKSQQLQEKQQQLL 1144

Query: 699  KLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQ 758
             +QE++++++ +  +I   L    K  E+  +++E  R E+      N +   +  K+ +
Sbjct: 1145 NVQEEMSEMQKKINEIEN-LKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK 1203

Query: 759  IINTMTQDLRGANEKLA--VAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLL 816
            ++  + +      + L   + E+ A  L+  KE LK++ + L + +E             
Sbjct: 1204 VLKELQKSFETERDHLRGYIREIEATGLQT-KEELKIAHIHLKEHQE------------- 1249

Query: 817  TNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT 876
                TI  +      +T Q +++Q    + E SH K  L+ E+   H      + +LL  
Sbjct: 1250 ----TIDELRRSVSEKTAQIINTQ----DLEKSHTK--LQEEIPVLHE-----EQELLPN 1294

Query: 877  KRQLDTETNLHLNTKELL--KNAQKEIATLKQ-HLSNMEVQVASQSSQRTGKGQPSNKED 933
             +++ +ET   +N  ELL  ++  K+  TL +  +  + +    Q SQ   K     +++
Sbjct: 1295 VKEV-SETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDN 1353

Query: 934  VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN---KEKQVTEEVRKNI 990
            +  +   L    +Q   LKE ++ + + +++ Q+     E+SLN   K+ + T+ V +  
Sbjct: 1354 LKTIKEALEVKHDQ---LKEHIRETLAKIQESQS---KQEQSLNMKEKDNETTKIVSEME 1407

Query: 991  EVRLKESAEFQTQLE-----KKLME-------VEKEKQELQDDKRRAIESMEQQLSELKK 1038
            + + K+SA  + ++E     K+L E       V KEK +LQ   +  ++S   QL E  K
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR-LQEVLQSESDQLKENIK 1466

Query: 1039 TLSSVQNEVQEALQRASTALSNEQQARRDC-----QEQAKIAV----------EAQNK-- 1081
             + +   E +E L+ A   L  +++   +      +++ +I+           + QNK  
Sbjct: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526

Query: 1082 --YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139
              YE+E   +   +  +Q    ++ +    R+  +   Q  ES++LE     +E +    
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ---- 1582

Query: 1140 DEVSKCVCRCEDLEKQNRLLH---DQIEKLSDKVVASVKEGVQGPLN-VSLSEEGKSQEQ 1195
            +E+   +   E++++    L    DQ+++ + ++VA +KE  +     + ++   ++QE+
Sbjct: 1583 EEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEK 1642

Query: 1196 ILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKT 1255
            + EI   ++ + E  +   E  + E++R  Q   +L   L+E++ S+  ER+ ++   +T
Sbjct: 1643 MCEI-EHLKEQFETQKLNLENIETENIRLTQ---ILHENLEEMR-SVTKERDDLRSVEET 1697

Query: 1256 MAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILP----LQEAN 1311
            +    + +K+     +  +  K  +EE + +   L++ Q  + KL   +      +    
Sbjct: 1698 LKVERDQLKENLRETITRDLEK--QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ 1755

Query: 1312 AELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQL 1371
             +L   +  L+A+   ++E+++     + HL  QQ+  D  + R ++SEK          
Sbjct: 1756 KDLEHSNDALKAQDLKIQEELR---IAHMHLKEQQETID--KLRGIVSEK---------- 1800

Query: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI 1431
            T+++  ++ ++  SNA L   Q  IQ LK + +++ T K+ +         + Q+KV  +
Sbjct: 1801 TDKLSNMQKDLENSNAKL---QEKIQELKANEHQLITLKKDVN--------ETQKKVSEM 1849

Query: 1432 TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK 1491
             Q+KK          ++K Q   + +   ++    Q+ H +++EM+ + +  +      +
Sbjct: 1850 EQLKK----------QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE 1899

Query: 1492 SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
            +L+ + + L+++L  +ET+AR+L+     +Q EL   R   ++     ++LR++I+EK  
Sbjct: 1900 TLKLERDQLKESL--QETKARDLE-----IQQELKTARMLSKEHKETVDKLREKISEK-- 1950

Query: 1552 KTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRIS 1611
                                        ++      LD+ KDEL  +I  L+ + E ++ 
Sbjct: 1951 --------------------------TIQISDIQKDLDKSKDELQKKIQELQKK-ELQLL 1983

Query: 1612 RLERELREHQER--HLEQRDEPQEPSNKVPEQQRQITLKTT 1650
            R++ ++    ++   +EQ  +  E  N   +  R    + T
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024



 Score =  206 bits (525), Expect = 2e-52
 Identities = 369/1812 (20%), Positives = 774/1812 (42%), Gaps = 265/1812 (14%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE 66
            Q +ER E   + + +Q  LE+     Q E D LK   E  ++E +Q   +I     H   
Sbjct: 904  QTVER-EKTLITEKLQQTLEEVKTLTQ-EKDDLKQLQESLQIERDQLKSDI-----HDTV 956

Query: 67   RLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRD 126
             +  +T+E   LR  LE L    + +     ++     RN+ ++     TK+E + +   
Sbjct: 957  NMNIDTQE--QLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG 1014

Query: 127  LIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE 186
            + +  +  ++  + LT DVK  NE +++       +Q K +ELQ    SV   +++L+ +
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKD-NEIIEQQRKIFSLIQEK-NELQQMLESVIAEKEQLKTD 1072

Query: 187  KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE-EVS----RLEEQMN 241
             +           EL+   DEL     +K  EI+  + N   KKE E+S    RL E   
Sbjct: 1073 LKENIEMTIENQEELRLLGDEL-----KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127

Query: 242  GLKTSNEHLQKHVEDLLTKLKEAKEQQASME--EKFHNEL-NAHIKLSNLYKSAADDSEA 298
             LK  ++ LQ+  + LL   +E  E Q  +   E   NEL N  + L ++     + ++ 
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187

Query: 299  --KSNELTRAVEELHKLLKEAGEANKAIQDHL----LEVE----QSKDQME------KEM 342
              ++ E  +++ +  K+LKE  ++ +  +DHL     E+E    Q+K++++      KE 
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247

Query: 343  LEKIGRLEK-------ELENANDL-LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMK 394
             E I  L +       ++ N  DL  S TK +  I    E   + P    V++  +  M 
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE-TQETMN 1306

Query: 395  LTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASL 454
              EL      T+D   L ++E +R+   L+E  +E + +   L ++R+  +  ++A+   
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEMERLR--LNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364

Query: 455  SVKLEQAMKE-IQRLQEDTDKANKQSSVLERDNR-------------------RMEIQVK 494
              +L++ ++E + ++QE   K  +  ++ E+DN                    R+EI++ 
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424

Query: 495  DLSQQIR---------------------VLLMELEEARGN-------HVIRDEEVSSAD- 525
             LS++++                     VL  E ++ + N       H+  +EE+  A  
Sbjct: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484

Query: 526  -ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE-----LGETREREEQETTSSKITEL 579
             +    E I++  V+    E      Q+ L A+ +     + E  E+EEQ     +I+E+
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ-FNIKQISEV 1543

Query: 580  QLKLESALTELEQLRKSRQHQMQLVDS--------IVRQRDMYRILLSQTTGVAIPLHAS 631
            Q K+ + L + ++ RK++   +Q ++S        +   ++  +I++ +   +     A 
Sbjct: 1544 QEKV-NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602

Query: 632  SLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEK 691
             ++   L    K        S       ++ T   E +  + +++ + E ++ +K   E 
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662

Query: 692  IQNEQL-------EKLQE------QVTDLRSQNTKISTQLDFASK--RYEMLQDNVEGYR 736
            I+ E +       E L+E      +  DLRS    +  + D   +  R  + +D  +   
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722

Query: 737  REITSLH-----ERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEML 791
             +I  +H     E   KL     ++   I+ M +DL  +N+ L     +A++LK ++E L
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL-----KAQDLKIQEE-L 1776

Query: 792  KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHL 851
            +++ + L +Q+E++   +   +     L  +Q  LE S  + ++++  +++  EH++  L
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI-QELKANEHQLITL 1835

Query: 852  KKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM 911
            KK + NE +++ +    L  Q+ D    L      +LN  + L    +E+ ++ +   N+
Sbjct: 1836 KKDV-NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894

Query: 912  EVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS 971
                         + + + K + D L   L++T+ +  ++++ LKT+    ++++  V  
Sbjct: 1895 R------------RVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDK 1942

Query: 972  LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE--LQDDKRRAIESM 1029
            L E ++++     +++K+++    E  +   +L+KK +++ + K++  +   K   +E +
Sbjct: 1943 LREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQL 2002

Query: 1030 EQQLSELKKTLSSVQ-------NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY 1082
            ++Q      ++ SV+        ++ E+L+          + RR  +E  K+  +     
Sbjct: 2003 KKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRR-IKESLKMERDQFIAT 2061

Query: 1083 ERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV 1142
             RE++  A D +  Q  K +   ++  +QHL E+ ++  S++ E    + E      D+ 
Sbjct: 2062 LREMI--ARDRQNHQ-VKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE-----MDDH 2113

Query: 1143 SKCVCRCE-DLEKQNRLLHD---------QIEKLSDKVVASVKEGVQGPLNVSLSEEGKS 1192
             +C+ R   DLEK+     +          +  L  K +  +    Q   ++      K 
Sbjct: 2114 YECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ-RCSMEFHRIMKK 2172

Query: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVT 1252
             + +L  +  I+ E+  +  +FE+  ++ +  ++ + +  + LQ+  D  + E   +++ 
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN 2232

Query: 1253 AKTMAQHEELMK----------KTETMNVVMETNKMLR--EEKERLEQDLQQMQAKVRK- 1299
                   EE++K          KTE   V+    +M +  EE      D+++++  ++K 
Sbjct: 2233 QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292

Query: 1300 ----------LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQ---- 1345
                          I+ +   + E  E+S  +  E    E+D+K  K +N+ L       
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKE---WEQDLKSLKEKNEKLFKNYQTL 2349

Query: 1346 --------QKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQ 1397
                    Q +P T++ +       V ++  Q  TE+I  L+  +  +  S  + ++ I 
Sbjct: 2350 KTSLASGAQVNPTTQDNK----NPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405

Query: 1398 SLKEDLNKVRTEKETIQKDLDAKI-IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVM 1456
             ++++L         +  D+ AK+   + E  K + + K          E ++  QDKV 
Sbjct: 2406 KMQKELE--------VTNDIIAKLQAKVHESNKCLEKTK----------ETIQVLQDKV- 2446

Query: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
               A  +  ++E+ +   +M+ +K  L + +  +K  E ++   + T+          Q+
Sbjct: 2447 ---ALGAKPYKEE-IEDLKMKLVKIDLEKMK-NAKEFEKEISATKATV--------EYQK 2493

Query: 1517 QTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAI-VAAKSKIAHLAGVKDQLT 1575
            + ++L  E  R  Q  QD +   E    Q + K         +   +K   L     +L 
Sbjct: 2494 EVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLE 2553

Query: 1576 KENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPS 1635
            KE  +LKQ+N  L +QK+EL      L ++ +   +  ER L+    + +   + P+ P 
Sbjct: 2554 KEISKLKQQNEQLIKQKNELLSNNQHLSNEVK---TWKERTLKREAHKQVTCENSPKSPK 2610

Query: 1636 -NKVPEQQRQIT 1646
                  +++QIT
Sbjct: 2611 VTGTASKKKQIT 2622



 Score =  202 bits (513), Expect = 4e-51
 Identities = 365/1764 (20%), Positives = 744/1764 (42%), Gaps = 286/1764 (16%)

Query: 24   KLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSLRL 80
            K +  LA  QS         + FK   ++ EQ+Y  + +      + +VN ++E Q    
Sbjct: 800  KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859

Query: 81   ELEKLNNQL----KALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
             L  L  +L    + L EK +E++   +    ++ Q       L+  +R+     E+L Q
Sbjct: 860  SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919

Query: 137  ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTW 196
             L    E+VK L ++  +    +  LQ++ D+L++                  +H     
Sbjct: 920  TL----EEVKTLTQEKDDLKQLQESLQIERDQLKSD-----------------IHD---- 954

Query: 197  LNTELKTKTDELLALGREKGNEILELKCNLENK-KEEVSR-LEEQMNGLKTSNEHLQKHV 254
                +   T E L    E   +  E    L++K  EEVSR L  + N  +T +E  QK V
Sbjct: 955  -TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013

Query: 255  EDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLL 314
                       +++  +E K    L A               + K NE+     ++  L+
Sbjct: 1014 ---------GIDKKQDLEAKNTQTLTA---------------DVKDNEIIEQQRKIFSLI 1049

Query: 315  KEAGEANKAIQDHLLEVEQSKDQMEK------EMLEKIGRLEKELENANDLLSATKRKGA 368
            +E  E  + ++  + E EQ K  +++      E  E++  L  EL+   +++ A ++  A
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV-AQEKNHA 1108

Query: 369  ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVK 428
            I  E EL+      A V +      KL E      E Q QLL  + E   + K ++EI  
Sbjct: 1109 IKKEGELSRTCDRLAEVEE------KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN 1162

Query: 429  -EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD--KANKQSSVLERD 485
             + E K   L  +  E ER +     L+ KL +  +E++ + ++    K  ++S   ERD
Sbjct: 1163 LKNELKNKELTLEHMETERLE-----LAQKLNENYEEVKSITKERKVLKELQKSFETERD 1217

Query: 486  NRR---MEIQVKDL--SQQIRVLLMELEEARG--NHVIRDEEVSSADISSSSEVISQHLV 538
            + R    EI+   L   +++++  + L+E +   + + R     +A I ++ ++   H  
Sbjct: 1218 HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTK 1277

Query: 539  SYRNIEELQQQNQRLLVALRELGETRER-------EEQETTSSKITELQLKLESALTELE 591
                I  L ++ Q LL  ++E+ ET+E         EQ TT    T  ++++E       
Sbjct: 1278 LQEEIPVLHEE-QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERL----- 1331

Query: 592  QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTV 651
            +L +  Q   + + S+ ++RD                   +L  +  A   K     +  
Sbjct: 1332 RLNEKFQESQEEIKSLTKERD-------------------NLKTIKEALEVKHDQLKEH- 1371

Query: 652  STPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQN 711
                    I  T A   ++  KQ Q +  N K++  E  KI +E      EQ     S  
Sbjct: 1372 --------IRETLAKIQESQSKQEQSL--NMKEKDNETTKIVSE-----MEQFKPKDSAL 1416

Query: 712  TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGAN 771
             +I  ++   SKR +   D ++   +E   L    + L + + + ++ I  +        
Sbjct: 1417 LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETE 1476

Query: 772  EKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT-IQGILERSE 830
            E+L VA      LK+++E +    V LS++   +   Q+    +   LQ  IQ I E+ E
Sbjct: 1477 EELKVAHC---CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE 1533

Query: 831  TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD-TKRQLDTETNLHLN 889
                Q    QI +++ +++ LK+  E+  + + +  ++++ ++L+ T R  +++  + + 
Sbjct: 1534 ----QFNIKQISEVQEKVNELKQFKEHR-KAKDSALQSIESKMLELTNRLQESQEEIQIM 1588

Query: 890  TKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL-VSQLRQTEE-- 946
             KE     ++E+  +++ L     Q+   + +   K + S +++   L ++ + +T+E  
Sbjct: 1589 IKE-----KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643

Query: 947  -QVNDLKERLKTSTSNVEQYQA----MVTSLEESLNKEKQVTEE--VRKNIEVRLKESAE 999
             ++  LKE+ +T   N+E  +     +   L E+L + + VT+E    +++E  LK   +
Sbjct: 1644 CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD 1703

Query: 1000 FQTQLEKKLMEV---EKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEV---QEALQR 1053
               QL++ L E    + EKQE        ++  ++ + +L+  +S   NE+   Q+ L+ 
Sbjct: 1704 ---QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760

Query: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA-AKEQVSKMASVRQH 1112
            ++ AL  +       QE+ +IA          L      ++ L+    E+  K++++++ 
Sbjct: 1761 SNDALKAQD---LKIQEELRIA-------HMHLKEQQETIDKLRGIVSEKTDKLSNMQKD 1810

Query: 1113 LEETTQKAESQLLECKASWEERERMLKD--EVSKCVCRCEDLEKQ--------------- 1155
            LE +  K + ++ E KA+  +   + KD  E  K V   E L+KQ               
Sbjct: 1811 LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870

Query: 1156 ---NRLLHDQIEKLSDKV-----VASVKEGV---QGPLNVSLSEEGKSQ---EQILEILR 1201
                + LH+ +E++   +     +  V+E +   +  L  SL E        +Q L+  R
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930

Query: 1202 FIRRE---------KEIAETRFEVAQVESLRYRQRVELLER--ELQELQDSLNAEREKVQ 1250
             + +E         ++I+E   +++ ++    + + EL ++  ELQ+ +  L   +E V 
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990

Query: 1251 VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEA 1310
            ++ K + + E+L K+ E  N+ M++   +R +  +L + L +   ++R +  +   L+  
Sbjct: 1991 MSHKKINEMEQLKKQFEAQNLSMQS---VRMDNFQLTKKLHESLEEIRIVAKERDELRRI 2047

Query: 1311 NAELS-EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
               L  E+   +   ++++  D      R  H V  +K        +LLS+ + H    +
Sbjct: 2048 KESLKMERDQFIATLREMIARD------RQNHQVKPEK--------RLLSDGQQHL--TE 2091

Query: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNK-VRTEKE---TIQKDLDAKIIDIQ 1425
             L E+  R+K E+ +  + + ++   +  L  DL K +  +KE    ++ +L    +  +
Sbjct: 2092 SLREKCSRIK-ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTK 2150

Query: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
               K  T  ++    +    ++LK     V +         +EQH S+ + +   + +++
Sbjct: 2151 HIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIK-------EEQHESINKFE--MDFIDE 2201

Query: 1486 AETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ 1545
             E K K L  ++++LQ+       E R+L            +L Q++       E++ + 
Sbjct: 2202 VE-KQKELLIKIQHLQQDCDVPSRELRDL------------KLNQNMD---LHIEEILKD 2245

Query: 1546 ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL---DVRITAL 1602
             +E E        + K++   +   + ++T+  EE       +++ K+ +   + RI  +
Sbjct: 2246 FSESE------FPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQV 2299

Query: 1603 KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI-----TLKTTPASGERG 1657
             + +  RI  +  E  E +ER      E ++    + E+  ++     TLKT+ ASG + 
Sbjct: 2300 NNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQV 2359

Query: 1658 IASTSDPPTANIKPTPVVSTPSKV 1681
              +T D    ++       T  K+
Sbjct: 2360 NPTTQDNKNPHVTSRATQLTTEKI 2383



 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 152/777 (19%), Positives = 302/777 (38%), Gaps = 164/777 (21%)

Query: 1006 KKLMEVEKEKQELQDDKRRAIESMEQ--QLSELKKTLSSVQNEVQEALQR-----ASTAL 1058
            K++M+++K+ +E+  + R      +Q  QL E K  L  VQNE  E L R     +S  L
Sbjct: 350  KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTL 409

Query: 1059 SNEQQARRDCQEQ---AKIAVEAQNKYERELML--------HAADVEALQAAKEQVSKMA 1107
              E +A+R  +      KI     + Y  +  +        H   +  L+   E V   +
Sbjct: 410  QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES 469

Query: 1108 SVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLL-HDQIEKL 1166
             V  +  +T  + E         W    ++L  E  +        +  N +L ++Q+   
Sbjct: 470  DVFSNTLDTLSEIE---------WNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520

Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
             +++   +KE              K+     E L    ++ +  +   E++ +++L    
Sbjct: 521  KEEMELKLKE--------------KNDLDEFEALERKTKKDQEMQLIHEISNLKNL---- 562

Query: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR--EEKE 1284
             V+  E   Q+L++ L+++ E ++     + + +E +   +  N+ M+ +  L   E+ +
Sbjct: 563  -VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK 621

Query: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
            +++Q L   +      + +   L+  N EL EK   L    K +E D++ ++++ +    
Sbjct: 622  QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681

Query: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
             Q D +               K +Q    EI +L         SL + +     + +DL 
Sbjct: 682  MQVDLE---------------KELQSAFNEITKL--------TSLIDGK-----VPKDL- 712

Query: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
                       +L+ KI D+Q+++    +  +  R       ELK+   +V     +   
Sbjct: 713  -------LCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQD 765

Query: 1465 DHQEQHVSVQEMQEL---------------------KETLNQAETKSKSLESQVENL--- 1500
              +E H+   E  +L                     K+ L   ++  KS + + +N    
Sbjct: 766  KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTL 825

Query: 1501 --------QKTLSEKE----------TEARNLQEQTVQLQSELSRLRQDLQDRT------ 1536
                    +  L E E           EA+        L++ELS   Q+LQ++T      
Sbjct: 826  HMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQER 885

Query: 1537 -TQEEQLRQQITEKEEKTRKAIVAAKSKIAH-----LAGVKDQLTKENEELKQRNGALDQ 1590
              + EQL++Q+ E  + T + +   K+ I       L  VK  LT+E ++LKQ   +L  
Sbjct: 886  LNEMEQLKEQL-ENRDSTLQTVEREKTLITEKLQQTLEEVK-TLTQEKDDLKQLQESLQI 943

Query: 1591 QKDEL--DVRIT-------------ALKS--QYEGRISRLERELREHQERHLEQRDEPQE 1633
            ++D+L  D+  T             AL+S  Q++  I+ L+ ++ E   R+L   +   E
Sbjct: 944  ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGE 1003

Query: 1634 PSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNK 1690
              ++  ++   I  K          A  +   TA++K   ++    K+ +     N+
Sbjct: 1004 TKDEFQQKMVGIDKKQDLE------AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 139/720 (19%), Positives = 285/720 (39%), Gaps = 120/720 (16%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRH----EKFKVESEQQYF--EIEKRLSH 63
            ER EL ++ +S++ + ++F+A  +  I   +  H    EK  +   QQ+    + ++ S 
Sbjct: 2040 ERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSR 2099

Query: 64   SQERL-----VNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
             +E L     +++  EC      L +L+  L+   E  KEL +    N+++    T+  E
Sbjct: 2100 IKELLKRYSEMDDHYEC------LNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIE 2153

Query: 119  ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS-DVSVK 177
            +L    +       R+ ++L+Y+   V ++ E+  ES   K E+   +DE++   ++ +K
Sbjct: 2154 KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES-INKFEMDF-IDEVEKQKELLIK 2211

Query: 178  YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEIL--ELKCNLENKKEEVSR 235
             +  + + +      ++  LN  +    +E+L    E     +  E +  L N+KE    
Sbjct: 2212 IQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQF 2271

Query: 236  LEEQMN----------GLKTSNEHL-------QKHVEDLLTKLKEAKEQQASMEEKFHNE 278
            LEE +N          G++  N+ +          +  ++ +  E +E+ A++ +++  +
Sbjct: 2272 LEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQD 2331

Query: 279  LNA----HIKLSNLYKSAADD--SEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
            L +    + KL   Y++      S A+ N  T+  +  H   +      + I++    + 
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH 2391

Query: 333  QSKDQ-MEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
            ++K+  M KE   KI +++KELE  ND+++  + K    S + L     T   +   V  
Sbjct: 2392 EAKESAMHKE--SKIIKMQKELEVTNDIIAKLQAK-VHESNKCLEKTKETIQVLQDKVAL 2448

Query: 392  GMKLTELYNAYVETQDQLL----LEKLEN-KRINKYLDEIVKEVEAKAPILKRQREEYER 446
            G K    Y   +E     L    LEK++N K   K +      VE +  +++  RE   R
Sbjct: 2449 GAKP---YKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505

Query: 447  AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLME 506
            +Q+A            ++   + E TD       +              + Q  + L+++
Sbjct: 2506 SQQA------------QDTSVISEHTDPQPSNKPLTCGGG-------SGIVQNTKALILK 2546

Query: 507  LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL------ 560
                                       S+H+   + I +L+QQN++L+    EL      
Sbjct: 2547 ---------------------------SEHIRLEKEISKLKQQNEQLIKQKNELLSNNQH 2579

Query: 561  ---------GETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR 611
                       T +RE  +  + + +    K+    ++ +Q+  S+  +  L D + ++ 
Sbjct: 2580 LSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKES 2639

Query: 612  DMYRILLSQTTGVAIPLHASSLDDVSLASTP--KRPSTSQTVSTPAPVPVIESTEAIEAK 669
                   S++  +  P      D+ SL   P  +        S P P       +  E K
Sbjct: 2640 PKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECK 2699


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  221 bits (563), Expect = 7e-57
 Identities = 344/1721 (19%), Positives = 709/1721 (41%), Gaps = 174/1721 (10%)

Query: 6    QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
            ++ L R EL +L +  + + ++   ++Q  +         F+ E E+++ + E  L   +
Sbjct: 207  EEQLRRRELLELRRKGREEKQQQRRERQDRV---------FQEEEEKEWRKRETVLRKEE 257

Query: 66   ERLVNETRECQ-SLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEK 124
            E+L  E  + Q  L+ E E+L    +    + ++ E  Q + +  + Q  R +EE   E+
Sbjct: 258  EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317

Query: 125  RDLIR-TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRL 183
            ++  R   ER  Q+ E   + ++R  E+ +E    + + + + ++    +   + RE++L
Sbjct: 318  QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377

Query: 184  EQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243
             +E++L   Q      +L+ +      L RE+     +L+   + ++E+  R E+Q+   
Sbjct: 378  RREQQLRREQQLRREQQLRREQQ----LRREQ-----QLRREQQLRREQQLRREQQLRRE 428

Query: 244  KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
            +    H QKH ++   +  + ++++     K   E   H +     +   D  E +    
Sbjct: 429  QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488

Query: 304  TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
             +  EE  +  +E  E     +      ++ K Q E+E L++  R E++L    +     
Sbjct: 489  LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE----- 543

Query: 364  KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK---RIN 420
            +R+  +L  EE   +           +   +  +L     E + Q L  + E +   R+ 
Sbjct: 544  ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603

Query: 421  KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
            +   E +++ E +   LKR+  E ER Q+ + S     EQ  +  Q+L+ +  +  +Q  
Sbjct: 604  REEVERLEQEERREQRLKREEPEEERRQQLLKS----EEQEERRQQQLRREQQERREQRL 659

Query: 481  VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
              E +  R+E ++K           E EE R     R++E++  +   + E I   +  +
Sbjct: 660  KREEEEERLEQRLK----------REHEEER-----REQELAEEEQEQARERIKSRIPKW 704

Query: 541  R---NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSR 597
            +     E   +Q++      ++ G+ R +E++E    + +ELQ + E      +Q  + R
Sbjct: 705  QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764

Query: 598  QH---QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP----KRPSTSQT 650
            +    Q Q  +   R R                L A           P    K     Q 
Sbjct: 765  RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824

Query: 651  VSTPAPVPVIESTEAIEAKAALKQLQE----IFENYKKEKAENEKIQNEQLEKLQEQVTD 706
                  +  +E  E ++ +   +QLQE    + E+ ++ +++ ++   +   +L+E+   
Sbjct: 825  REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884

Query: 707  LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD 766
             R          +   K  ++LQ+  E  +RE     ER ++     ++QEQ      ++
Sbjct: 885  RRHTLYAKPALQEQLRKEQQLLQEEEEELQRE-----EREKR-----RRQEQERQYREEE 934

Query: 767  LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGIL 826
                 E+  + E R +  ++E+E     + +L Q+ E LL E+  +              
Sbjct: 935  QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR------------- 981

Query: 827  ERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNL 886
             R E E K R   ++++ E ++   +++     E      +  ++Q  + +   +     
Sbjct: 982  RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041

Query: 887  HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
             L  +E     ++E+   ++ L   E +   +      + Q   +E++     QL + E 
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQEL---ERQYRKEEELQQEEEQLLREEP 1098

Query: 947  QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
            +    +ER +      E  Q     L E   K +      R+ +E + +E  E Q Q E+
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRR------RQELERQYREEEEVQ-QEEE 1151

Query: 1007 KLMEVEKEKQELQDDKR--RAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
            +L+  E EK+  Q+ +R  R  E ++Q+  +L +     + + +E   R    L  +++ 
Sbjct: 1152 QLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211

Query: 1065 RRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR----------QHLE 1114
            +R   E  +  ++ Q + E+E  +    V       EQ  ++   +          QHL 
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271

Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
               Q+ + +  + +  W++R+R   +E  + + R E  E + R    Q EK   +     
Sbjct: 1272 GEQQERDRE--QERRRWQQRDRHFPEE--EQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327

Query: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFE--------VAQVESLRYRQ 1226
            K   Q        EE   QE+  + LR   R+++  E            + + + LR ++
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387

Query: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKER- 1285
            R     +E Q+L+     ++ +     K   + ++L ++        E  ++ R+E+ER 
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447

Query: 1286 -LEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
             LE++ Q  Q + RK   +   LQE   +   +    + ++K LEE+ +  +        
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ---ERDRKFLEEEQQLRRQERDRKFR 1504

Query: 1345 QQKDPDTEEYRKLL-SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED- 1402
            +Q+    E  RK L  E+++H    QQ   +  + + ++ R        Q+  +  +E+ 
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHR---QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561

Query: 1403 -LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGR-----RYKTQYEELKAQQDKVM 1456
             L + R E++  +++ D K    ++KV+   Q +K        R +   ++L+ ++D+  
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621

Query: 1457 ETSAQSSGDHQEQHVSVQE-------------MQELKETLNQAETKSKSLESQV------ 1497
                Q   + +EQ +  QE              QE ++ L     +    E Q+      
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681

Query: 1498 -----ENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552
                 +   +   E+E + R  + +   LQ E    RQ+L+ +  +EEQLRQ+ TE+E+ 
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE-TEQEQL 1740

Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQ-KDELDVR----ITALKSQYE 1607
             R+       KI      ++QL  E EE + R    D++ ++E  +R       L+SQ  
Sbjct: 1741 RRQ---ERYRKILE----EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793

Query: 1608 GRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLK 1648
             R  R E +LR+ +E   EQ+  PQ+   K   ++ Q+ L+
Sbjct: 1794 DRKFREEEQLRQERE---EQQLRPQQRDGKYRWEEEQLQLE 1831



 Score =  208 bits (529), Expect = 6e-53
 Identities = 365/1805 (20%), Positives = 747/1805 (41%), Gaps = 199/1805 (11%)

Query: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGL-----KGRHEK-----------FKVESEQQY 54
            R E  +L     ++ E+F  ++Q     L     KGR EK           F+ E E+++
Sbjct: 187  RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246

Query: 55   FEIEKRLSHSQERLVNETRECQ-SLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQF 113
             + E  L   +E+L  E  + Q  L+ E E+L    +    + ++ E  Q + +  + Q 
Sbjct: 247  RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306

Query: 114  TRTKEELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS 172
             R +EE   E+++  R   ER  Q+ E   + ++R  E+ +E    + + + + ++    
Sbjct: 307  RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366

Query: 173  DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE 232
            +   + RE++L +E++L   Q      +L+ +      L RE+     +L+   + ++E+
Sbjct: 367  EQEEERREQQLRREQQLRREQQLRREQQLRREQQ----LRREQ-----QLRREQQLRREQ 417

Query: 233  VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
              R E+Q+   +    H QKH ++   +  + ++++     K   E   H +     +  
Sbjct: 418  QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477

Query: 293  ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
             D  E +     +  EE  +  +E  E     +      ++ K Q E+E L++  R E++
Sbjct: 478  RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537

Query: 353  LENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLE 412
            L    +     +R+  +L  EE   +           +   +  +L     E + Q L  
Sbjct: 538  LRREQE-----ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592

Query: 413  KLENK---RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469
            + E +   R+ +   E +++ E +   LKR+  E ER Q+ + S     EQ  +  Q+L+
Sbjct: 593  EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE----EQEERRQQQLR 648

Query: 470  EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
             +  +  +Q    E +  R+E ++K           E EE R     R++E++  +   +
Sbjct: 649  REQQERREQRLKREEEEERLEQRLK----------REHEEER-----REQELAEEEQEQA 693

Query: 530  SEVISQHLVSYRNIEELQQQNQRLLVALR---ELGETREREEQETTSSKITELQLKLESA 586
             E I   +  ++   E +   ++  V  R   + G+ R +E++E    + +ELQ + E  
Sbjct: 694  RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753

Query: 587  LTELEQLRKSRQH---QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP- 642
                +Q  + R+    Q Q  +   R R                L A           P 
Sbjct: 754  AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813

Query: 643  ---KRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699
               K     Q       +  +E  E ++ +   +QLQE  +  ++++      +  + +K
Sbjct: 814  EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873

Query: 700  LQEQVTDLRSQN-----TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
             + Q+ + R +       K + Q +   K  ++LQ+  E  +RE      R Q+     +
Sbjct: 874  WRWQLEEERKRRRHTLYAKPALQ-EQLRKEQQLLQEEEEELQREERE-KRRRQEQERQYR 931

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
            ++EQ+     Q LR   EK    E R    +K+K++ +  E  L ++ E    ++R +  
Sbjct: 932  EEEQLQQEEEQLLREEREKRRRQE-RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 815  LLTN-LQTIQGILERSETETKQRLS--SQIEKLEHEISHLKKKLENEVEQRHTLTRNL-- 869
                 LQ  +  L R E E ++R     Q  K +      ++ L  E E+R    R    
Sbjct: 991  REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050

Query: 870  --DVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ 927
              + +L   + QL  E       +EL +  +KE   L+Q    +  +   +  ++  + Q
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKE-EELQQEEEQLLREEPEKRRRQERERQ 1109

Query: 928  PSNKEDVDDLVSQLRQTEEQVNDLKE--RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
               +E++     QL + E +    +E  R       V+Q +  +   E    + +++  +
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ 1169

Query: 986  VRKNIEVRLKESAEFQTQLEKKLMEVEK---EKQELQDDKRRAIESMEQQLSELK----- 1037
             R+  E++ +E    + + EK+  E E+   E++ELQ  KR+     E Q S+LK     
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229

Query: 1038 -KTLSSVQNEV------QEALQRASTALSNEQQARRDCQ----EQAKIAVEAQNKYEREL 1086
             K  +   N+V       E  ++   +   ++Q+++D Q    EQ +   E + +  ++ 
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289

Query: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
              H  + E L+  +++ +K    +   E+   + E    E K   +E +R  ++E     
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER---EEKRRRQETDRKFREEEQLL- 1345

Query: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE 1206
               ++ E+Q     ++  K  ++ +   ++G +      L EE + + Q  E  +F++ E
Sbjct: 1346 ---QEREEQPLRRQERDRKFREEELRHQEQGRK-----FLEEEQRLRRQERE-RKFLKEE 1396

Query: 1207 KEIA--ETRFEVAQVESLRYRQRVELLERE------LQELQDSLNAEREKVQVTAKTMAQ 1258
            +++   E   ++ Q    ++R+  + L R+       +E Q     ERE+  +  +   +
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456

Query: 1259 HEELMKKTETMNVVMETNK--MLREEKER--LEQDLQ-QMQAKVRKLELDILPLQEANAE 1313
             E   K  E   ++ E  +  + R+E++R  LE++ Q + Q + RK     L  QE   +
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516

Query: 1314 LSEKSGML---QAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQ 1370
              E+   L   Q ++K L+E+ +  +        Q +D    E  +L  E+E      Q+
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576

Query: 1371 LTEEIGRLKAEIARSNAS---LTNNQNLI-----QSLKEDLNKVRTEKETIQKDLDAKII 1422
               +    + ++ R       + + Q L      Q L+++ ++   E E + ++ + + +
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636

Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE----MQE 1478
              QE+ +   + +   RR + + ++L+  +D+      Q   + +EQ +  QE     +E
Sbjct: 1637 HRQERDRKFLEEEPQLRRQERE-QQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695

Query: 1479 LKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQ---------------- 1522
             ++ L + E + K L+ + +  ++ L  K  E   L+++T Q Q                
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755

Query: 1523 ---SELSRLRQDLQDRT-TQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
                E  +LR+  +DR   +EEQLRQ+  E++ +++++    + +        +QL +E 
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE--------EQLRQER 1807

Query: 1579 EELK----QRNGALDQQKDELDVR--------------------ITALKSQYEGRISRLE 1614
            EE +    QR+G    ++++L +                      T  KS+ E +    E
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867

Query: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQI-TLKTTPASGERGIASTSDPPTANIKPTP 1673
             E +  QER  + R+E      K  ++ RQ+  +K+    G   +    +P T      P
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL---EPGTHQFASVP 1924

Query: 1674 VVSTP 1678
            V S+P
Sbjct: 1925 VRSSP 1929



 Score =  185 bits (469), Expect = 5e-46
 Identities = 361/1714 (21%), Positives = 718/1714 (41%), Gaps = 222/1714 (12%)

Query: 31   DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETR---------------EC 75
            D+Q E +  + R +K + E E++  E E++ S  QERL    R               E 
Sbjct: 126  DRQLEEEPGQRRRQK-RQEQERELAEGEEQ-SEKQERLEQRDRQRRDEELWRQRQEWQER 183

Query: 76   QSLRLELEKLNNQLKALTEKNKELEIAQDRNIA-IQSQFTRTKEELEAEKRDLIRTNERL 134
            +  R E E+L +     TE+  + E  + R +  ++ +    K++   E++D +   E  
Sbjct: 184  EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE-- 241

Query: 135  SQELEYLTED--VKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS 192
             +E E+   +  +++  EKL+E    +   Q +L E +     ++ +E R E+++E    
Sbjct: 242  -EEKEWRKRETVLRKEEEKLQEEEPQR---QRELQEEEEQLRKLERQELRRERQEEEQQQ 297

Query: 193  QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQK 252
            Q      +L+ K +E     +E+  E  E +   E ++E+  R E++    +   + L++
Sbjct: 298  QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE----ERREQQLRR 353

Query: 253  HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHK 312
              E+   + +  +EQ+   EE+   +L    +L    +   +    +  +L R  +   +
Sbjct: 354  EQEEERREQQLRREQE---EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410

Query: 313  LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
                  +  +  Q    E E+ + + + E   +  RL++E E   D L           E
Sbjct: 411  QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR---------E 461

Query: 373  EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL----DEIVK 428
            EE                     TE +    E + Q L    E +R  ++L    +E  +
Sbjct: 462  EE---------------------TERHEQ--ERRKQQLKRDQEEERRERWLKLEEEERRE 498

Query: 429  EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRR 488
            + E +   L+R++EE    +        +L+Q ++  Q+L+ + ++  +Q  +L+R+   
Sbjct: 499  QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ--LLKREEE- 555

Query: 489  MEIQVKDLSQQIRV--LLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEEL 546
                 K L Q+ R   L  E EE R   + R+EE     +    E   +  +    +E L
Sbjct: 556  -----KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610

Query: 547  QQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDS 606
            +Q+ +R     RE  E   R++   +  +    Q +L     E  + R  R+ + + ++ 
Sbjct: 611  EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670

Query: 607  IVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI 666
             +++                  H     +  LA   +  +  +  S    +P  +     
Sbjct: 671  RLKRE-----------------HEEERREQELAEEEQEQARERIKSR---IPKWQWQLES 710

Query: 667  EAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE 726
            EA A   ++       +  K E ++ + EQ EK + + ++L+ Q  + + +     +  E
Sbjct: 711  EADARQSKVYS-----RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR---QQQEEE 762

Query: 727  MLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKK 786
              +D    ++ E  S   R Q+L+A    +EQ    +  + R   E+  + E   +  ++
Sbjct: 763  QRRDFTWQWQAEEKSERGR-QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821

Query: 787  EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEH 846
             +   +  E++  ++ E L   +R Q      LQ  +  L+  +   + +   + +K   
Sbjct: 822  RQRREREKELQFLEEEEQLQRRERAQ-----QLQEEEDGLQEDQERRRSQEQRRDQKWRW 876

Query: 847  EISHLKKKLENEVEQRHTLTRNLDVQ-LLDTKRQLDTETNLHLNTKELLKNAQKEIATL- 904
            ++   +K+      +RHTL     +Q  L  ++QL  E    L  +E  K  ++E     
Sbjct: 877  QLEEERKR------RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930

Query: 905  --KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV---NDLKERLKTST 959
              ++ L   E Q+  +  ++  + +   +   D    +L+Q EEQ+      K R +   
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKD---KKLQQKEEQLLGEEPEKRRRQERE 987

Query: 960  SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019
                + + +    E+ L +E++  +  R+  E + ++  E Q Q E++L+  E+EK+ LQ
Sbjct: 988  KKYREEEELQQEEEQLLREERE--KRRRQEWERQYRKKDELQ-QEEEQLLREEREKRRLQ 1044

Query: 1020 DDKRRAIE------SMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNE-------Q 1062
            + +R+  E        EQ L E ++T    + E Q    E LQ+    L  E       Q
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104

Query: 1063 QARRDCQEQAK--------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASV---RQ 1111
            +  R C+E+ +        +  E + +  +EL     + E +Q  +EQ+ +       RQ
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164

Query: 1112 HL------EETTQKAESQLL--ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQI 1163
             L      EE  Q+ E QLL  E +   +ERER  ++E        E+L++Q R    + 
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE--------EELQRQKRKQRYRD 1216

Query: 1164 E-KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI----LRFIRREKEIAETRFEVAQ 1218
            E + SD       E      +  +  +G+  EQ  ++    LR  + ++++     E  +
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276

Query: 1219 VESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE--LMKKTETMNVVMETN 1276
             +  + R+R +  +R   E ++ L  E +K        +Q E+  L ++ E      ET+
Sbjct: 1277 RDREQERRRWQQRDRHFPE-EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335

Query: 1277 KMLREEKERLEQDLQQ---MQAKVRKLELDILPLQEANAELSEKSGMLQAEKK----LLE 1329
            +  REE++ L++  +Q    Q + RK   + L  QE   +  E+   L+ +++    L E
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395

Query: 1330 EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASL 1389
            E   R + R Q L  Q +D    E  + LS +E    R ++  EE  +++ +  R    L
Sbjct: 1396 EQQLRCQEREQQL-RQDRDRKFREEEQQLSRQE----RDRKFREEEQQVRRQ-ERERKFL 1449

Query: 1390 TNNQNLIQSL------KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT 1443
               Q L Q        +E L + R E++  +++ D K ++ ++      Q+++  R  K 
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ------QLRRQERDRKF 1503

Query: 1444 QYEELKAQQ-DKVMETSAQSSGDHQEQHVSVQEMQELK-----ETLNQAETKSKSLESQV 1497
            + +EL++Q+ ++      Q     Q Q   +QE Q+L+     +   Q   +    E Q+
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563

Query: 1498 --ENLQKTLSEKETEAR-NLQEQTVQLQSELSRLRQDLQDRTTQE--EQLRQQITEKEEK 1552
              E  ++ LS +E + +  L+EQ V+ Q +  +  +D Q    QE  +QLRQ+   K  +
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623

Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS-QYEGRIS 1611
              + +   + +  H    +D+   E E   +R     Q + + D +    +    EG   
Sbjct: 1624 DEQLLQEREEQQLH-RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682

Query: 1612 RLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645
            +L R+ R+ + R  EQ+   QE   K  ++++Q+
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716



 Score =  143 bits (360), Expect = 2e-33
 Identities = 205/1038 (19%), Positives = 452/1038 (43%), Gaps = 99/1038 (9%)

Query: 661  ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
            E  E  E +A  +QLQ    +  +E  + E+++  +L +L+ +  + + Q  +      F
Sbjct: 179  EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238

Query: 721  ASKRYEMLQDNVEGYRREITSLHERN-QKLTATTQKQEQIINTMTQDLRGANEKLAVAEV 779
              +  +  +      R+E   L E   Q+     +++EQ+     Q+LR   ++    E 
Sbjct: 239  QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE---EEQ 295

Query: 780  RAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSS 839
            + + L++E+++ +  E    +Q+E    +Q  +       Q  +   ++   E ++R   
Sbjct: 296  QQQRLRREQQLRRKQEEERREQQEERREQQERRE------QQEERREQQLRREQEERREQ 349

Query: 840  QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQK 899
            Q+ + E E    +++L  E E+     +    Q L  ++QL  E  L    +E     ++
Sbjct: 350  QLRR-EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR---REQQLRREQ 405

Query: 900  EIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVND-LKERLKTS 958
            ++   +Q     +++   Q  +   + +   K + +    +L++ +E+  D LK   +T 
Sbjct: 406  QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465

Query: 959  TSNVEQYQAMVTSLEESLNKEKQVT---EEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK 1015
                E+ +  +   +E   +E+ +    EE R+  E R ++    Q +  ++ ++ ++E+
Sbjct: 466  RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525

Query: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC-----QE 1070
            + LQ  + R+ + + ++  E ++ L   + E +   +R    L  EQ+ RRD      +E
Sbjct: 526  ERLQQ-RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584

Query: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKAS 1130
            + +  ++ + +   E  L   +VE L+  + +  ++       EE  ++   QLL+ +  
Sbjct: 585  RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR-----EEPEEERRQQLLKSEEQ 639

Query: 1131 WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEG 1190
             E R++ L+ E  +         ++ RL  ++ E+  ++ +    E  +    ++  E+ 
Sbjct: 640  EERRQQQLRREQQE--------RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691

Query: 1191 KSQEQI----------LEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
            +++E+I          LE     R+ K  +  R +  Q       ++    E ELQ  ++
Sbjct: 692  QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751

Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
                 +++ +   +      +  +K+E     +     LRE++ER      Q++A+ R+ 
Sbjct: 752  ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER------QLRAEERQQ 805

Query: 1301 -ELDILPLQEANAELSEKSGMLQAEKKLLEEDVK-RWKARNQHLVSQQKDPDTEEYRKLL 1358
             E   LP +E   +   +    + E + LEE+ + + + R Q L  ++     ++ R+  
Sbjct: 806  REQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRS 865

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNA---SLTNNQNLIQSLKEDLNKVRTEKETIQK 1415
             E+    K   QL EE  R +  +    A    L   Q L+Q  +E+L +   EK   Q+
Sbjct: 866  QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925

Query: 1416 DL-----DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVM-----ETSAQSSGD 1465
                   + ++   +E++    + K+  +  + QY + K  Q K       E   +   +
Sbjct: 926  QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985

Query: 1466 HQEQHVSVQEMQELKETLNQAETKSKSLES---------QVENLQKTLSEKETEARNLQE 1516
             ++++   +E+Q+ +E L + E + +  +          +++  ++ L  +E E R LQE
Sbjct: 986  REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045

Query: 1517 QTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK 1576
            +  Q + E     ++LQ    +EEQL  +  E+E + R+ +     K   L   ++QL +
Sbjct: 1046 RERQYREE-----EELQQ---EEEQLLGE--ERETRRRQELERQYRKEEELQQEEEQLLR 1095

Query: 1577 ENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQ--ERHLEQRDEPQEP 1634
            E  E ++R     Q ++E +++      Q E ++ R ERE R  Q  ER   + +E Q+ 
Sbjct: 1096 EEPEKRRRQERERQCREEEELQ------QEEEQLLREEREKRRRQELERQYREEEEVQQE 1149

Query: 1635 SNKV----PEQQRQITLK 1648
              ++    PE++R+  L+
Sbjct: 1150 EEQLLREEPEKRRRQELE 1167



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 91/473 (19%), Positives = 205/473 (43%), Gaps = 49/473 (10%)

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L EE +++    E L   RR++E           +  R+  R   LE E  + +     E
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEE-----------DQRRFEPRDRQLEEEPGQRRRQKRQE 143

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRK------ 1299
            +E+     +  ++ +E +++ +      E  +  +E +ER E+  ++ Q +  K      
Sbjct: 144  QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE 203

Query: 1300 -------LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
                      ++L L+    E  ++    + ++   EE+ K W+ R   L  +++    E
Sbjct: 204  FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263

Query: 1353 E--YRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410
            E   ++ L E+E   +++++  +E+ R + E  +    L   Q L +  +E+  + + E+
Sbjct: 264  EPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321

Query: 1411 ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
                          +++ +   Q ++  ++ + + EE + QQ        +   + +EQ 
Sbjct: 322  R-------------EQQERREQQEERREQQLRREQEERREQQ-----LRREQEEERREQQ 363

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
            +  ++ +E +E   + E + +  E Q+   Q+   E++        +  QL+ E  +LR+
Sbjct: 364  LRREQEEERREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRR 421

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q R  QEE+  +Q  E+E + ++     + +   L   ++    E E  KQ+    DQ
Sbjct: 422  EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL-KRDQ 480

Query: 1591 QKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQR 1643
            +++  +  +   + +   +  R E++LR  QE   EQR + QE   ++ ++ R
Sbjct: 481  EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 122/609 (20%), Positives = 238/609 (39%), Gaps = 77/609 (12%)

Query: 24   KLEKFLADQQSEIDGLKGRHEKFKVESEQ-------QYFEIEKRLSHSQERLVNETRECQ 76
            K E+ L  Q+ E    + R  KF+ E +Q       + F  E++    QER      E Q
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453

Query: 77   SLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL-IRTNERLS 135
             LR E  +   + + L ++ +E ++ +        +F   +++L  ++RD   R  E  S
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQER---DRKFLEEEQQLRRQERDRKFREQELRS 1510

Query: 136  QELEY-LTEDVKRLNEKLKESNTTKGELQLKLDEL---QASDVSVKYREK-RLEQEKELL 190
            QE E    E+ ++L+ + ++    + E QL+  E    +  D   K+RE+ +L QE+E  
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE-- 1568

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
              Q +    + K + +E     +E+  + +E         E+  R +E    L+   +  
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFME--------DEQQLRRQEGQQQLRQERDRK 1620

Query: 251  QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEEL 310
             +  E LL   +E +EQQ   +E+    L    +L        +  +   ++  R   E 
Sbjct: 1621 FREDEQLL---QEREEQQLHRQERDRKFLEEEPQLRR-----QEREQQLRHDRDRKFREE 1672

Query: 311  HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAIL 370
             +LL+E  E     Q+   +  + + Q+ ++  E+    E++     +L    + +  + 
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732

Query: 371  SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
             E E                               Q+QL  ++    R  K L+E     
Sbjct: 1733 QETE-------------------------------QEQLRRQE----RYRKILEEEQLRP 1757

Query: 431  EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME 490
            E +   L+RQ    ER +K      ++ E+  ++++  + D     ++    ER+ +++ 
Sbjct: 1758 EREEQQLRRQ----ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR 1813

Query: 491  IQVKDLSQQIRVLLMELEEARGN-HVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
             Q +D   +     ++LEE        RD +  + +  ++ E   +        EE +++
Sbjct: 1814 PQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR 1873

Query: 550  NQRLLVALRELGETREREEQETTS-SKITELQLKLESALTE--LEQLRKSRQHQMQLVDS 606
             +R      E    +++EEQ      +I   + K    L E    Q          L + 
Sbjct: 1874 QERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEY 1933

Query: 607  IVRQRDMYR 615
            I  QR  YR
Sbjct: 1934 IQEQRSQYR 1942



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 38/194 (19%), Positives = 89/194 (45%), Gaps = 12/194 (6%)

Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
            Q++G  +E+       + L +   Q E + +  E +   L++   ++  + R  QE+ + 
Sbjct: 91   QATGLDEEKRARCDGKESLLQDRRQEEDQRR-FEPRDRQLEEEPGQRRRQKRQEQERELA 149

Query: 1521 LQSELSRLRQDLQ--DRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
               E S  ++ L+  DR  ++E+L +Q  E +E+  +   A + ++    G + +   + 
Sbjct: 150  EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR--AEEEQLQSCKGHETEEFPDE 207

Query: 1579 EELKQRN-------GALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEP 1631
            E+L++R        G  ++Q+   + +    + + E    + E  LR+ +E+  E+  + 
Sbjct: 208  EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267

Query: 1632 QEPSNKVPEQQRQI 1645
            Q    +  EQ R++
Sbjct: 268  QRELQEEEEQLRKL 281


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  216 bits (549), Expect = 3e-55
 Identities = 324/1692 (19%), Positives = 721/1692 (42%), Gaps = 235/1692 (13%)

Query: 9    LERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERL 68
            L R  + +L KS+ + +E  ++ Q  E D + GR    + E ++   E+++ L  +Q   
Sbjct: 1508 LARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL- 1565

Query: 69   VNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLI 128
               +  C+SL+L LE L    + L    KE+E  +   IA  +++    +EL+ E   L+
Sbjct: 1566 ---SSSCESLKLALEGLTEDKEKLV---KEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619

Query: 129  RTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKE 188
            ++ E +S E E +   V+ + ++ +E             +L++++ + K  EK+L++ ++
Sbjct: 1620 QSYENVSNEAERIQHVVEAVRQEKQEL----------YGKLRSTEANKKETEKQLQEAEQ 1669

Query: 189  LLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNE 248
                       E++   +++    + K  +ILEL+       EE  RL  +++    + +
Sbjct: 1670 -----------EMEEMKEKMRKFAKSKQQKILELE-------EENDRLRAEVH---PAGD 1708

Query: 249  HLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVE 308
              ++ +E LL+         ASM+E+       +  LS  ++S   + ++ S E+     
Sbjct: 1709 TAKECMETLLSS-------NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD--- 1758

Query: 309  ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGA 368
                 LK   E N + Q +L E  +  D       E    +  E E  + L  +T+    
Sbjct: 1759 -----LKHQIEGNVSKQANL-EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR---- 1808

Query: 369  ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL-------EKLENKRINK 421
                   +   P+A +    V       +  N Y++  DQL         EK +NK  ++
Sbjct: 1809 ----PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQ 1864

Query: 422  YLDE----IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANK 477
             L+     ++ ++  K   LK  +EE  +       L+ ++++ +  + +L+E  ++   
Sbjct: 1865 TLENEKNTLLSQISTKDGELKMLQEEVTKMNL----LNQQIQEELSRVTKLKETAEE--- 1917

Query: 478  QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
                 E+D         DL +++   L EL  + GN+    ++V+ A I +  E++   +
Sbjct: 1918 -----EKD---------DLEERLMNQLAELNGSIGNYC---QDVTDAQIKN--ELLESEM 1958

Query: 538  VSYRN-IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKS 596
             + +  + EL+++ Q+L+    ++     +E  E       E   K  S   EL++L K 
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK--SHAKELQELLKE 2016

Query: 597  RQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAP 656
            +Q +++ +     Q+D  R    Q    A+     +L+ V   S      T + ++    
Sbjct: 2017 KQQEVKQL-----QKDCIRY---QEKISALERTVKALEFVQTESQKDLEITKENLAQ--- 2065

Query: 657  VPVIESTEAIEAKAALKQLQEIFENYKKEKA----ENEKIQNEQLEKLQEQVTDLRSQNT 712
               +E  +  +A+A L   + + ++ + E A    +N K++ E     +   + ++ ++ 
Sbjct: 2066 --AVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2121

Query: 713  KISTQLDFASKRY----EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
             +  +L+ A +++    + +Q+ ++  RRE   L E   ++  T  K+++ +  + ++L 
Sbjct: 2122 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181

Query: 769  GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT--NLQTIQGIL 826
                +LA       +L+ +++ + + E +  +++ S   + + + + L   N   ++  L
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRV-IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240

Query: 827  ERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNL 886
             +     ++ L   I +LEH+    + K + EV+ +  +   L  +  +   QL+     
Sbjct: 2241 RQMSIHMEE-LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE----- 2294

Query: 887  HLNTKELLKNAQKEIATLKQHLSNMEVQVASQS-SQRTGKGQPSNKEDVDDLVSQLRQTE 945
               T+ L  ++Q E+A L+  L +++ Q+   S S    K Q  N E +      +RQ E
Sbjct: 2295 --ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI------IRQQE 2346

Query: 946  EQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAEFQTQL 1004
              + + K   +   ++++  + + + L E +N KE+++   +    E      AE + Q 
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406

Query: 1005 EKKLMEVE----KEKQE---LQDDKRRAIESMEQQLSELKKTLS-SVQNEVQ-EALQRAS 1055
            +K++ E+E    +E++E   L+++ ++A++   Q +  LK     ++Q + Q ++  ++ 
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466

Query: 1056 TALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
            ++L N++          +I  + Q   ER L +     + +Q A  + +K          
Sbjct: 2467 SSLQNDRD---------RIVGDYQQLEERHLSIILEKDQLIQEAAAENNK---------- 2507

Query: 1116 TTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK 1175
                                  LK+E+       +DL  +N  L  ++ +  +       
Sbjct: 2508 ----------------------LKEEIRGLRSHMDDLNSENAKLDAELIQYRED------ 2539

Query: 1176 EGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLEREL 1235
                  LN  ++ +   Q+Q+LE+     +E E    + E    ES    + +      L
Sbjct: 2540 ------LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593

Query: 1236 QELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQA 1295
            QE +  L+ E E ++V+   + +    +++  T+ +     K+  EE  RL       Q 
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653

Query: 1296 KVRKLELDILPLQ-EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEY 1354
            ++ +LE +++ +Q EA  ++ E    L+ E K L  D          ++  + +   E  
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA--------GIMRNETETAEERV 2705

Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
             +L  +     +++  +T+E   L A+I     S+++ QN      E+L++++ + +   
Sbjct: 2706 AELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASL 2765

Query: 1415 KDL-------------DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ 1461
            K+L             DA + +    + + T+   +    K   ++L ++ ++++  S+Q
Sbjct: 2766 KELAQLKEQGLLNRERDALLSETAFSMNS-TEENSLSHLEKLN-QQLLSKDEQLLHLSSQ 2823

Query: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKET---EARNLQEQT 1518
                + +     + M  L+   +    + +      E  Q++ ++  T   E ++L++  
Sbjct: 2824 LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883

Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
              LQ++  RL ++L++   Q  Q+ Q+ITE     +  +   + K      ++++L +EN
Sbjct: 2884 SSLQNDRDRLLKELKNLQQQYLQINQEITEL-HPLKAQLQEYQDKTKAFQIMQEELRQEN 2942

Query: 1579 EELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKV 1638
               +     L  +K   ++    +K QY   IS  +++L   Q    E R    +     
Sbjct: 2943 LSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK 3002

Query: 1639 PEQQRQITLKTT 1650
             + QRQ + +T+
Sbjct: 3003 VQYQRQASPETS 3014



 Score =  206 bits (524), Expect = 2e-52
 Identities = 345/1785 (19%), Positives = 762/1785 (42%), Gaps = 215/1785 (12%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
            L Q L + EL         K+++ L +++ +++ L+   E    E +QQ  EI   ++  
Sbjct: 864  LSQALSQKELEI------TKMDQLLLEKKRDVETLQQTIE----EKDQQVTEISFSMT-- 911

Query: 65   QERLVNETRECQSLRLELEKLNNQLKALT--EKNKELEIAQDRNIA-------------- 108
             E++V    E  SL +E++ L  QL  L+  E+ K+ ++ +D  ++              
Sbjct: 912  -EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG 970

Query: 109  ------IQSQFTRTKEELEAEKRDL---IRTNERLSQELEYLTEDVKRLNEKLKE----S 155
                  +Q +F   K+E E  KR L   +   + L Q +  L E++  L ++ K+    S
Sbjct: 971  QISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS 1030

Query: 156  NTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREK 215
             T +GE++   +  + S+  V  + + +E   +   S+       ++   +E LA   + 
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090

Query: 216  GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275
               + ++   L++K  ++  L+ +++         Q  ++ L+T   +A +  +    K 
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEIS-------ENQAIIQKLITSNTDASDGDSVALVKE 1143

Query: 276  HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI-------QDHL 328
               ++     S+ +     + E K   L +  E+L K L+EA  + KAI       + HL
Sbjct: 1144 TVVISPPCTGSSEHWKP--ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL 1201

Query: 329  LE-VEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK------GAILSEEELAAMSPT 381
             E ++Q KD   + + E+     KE EN  D L   + +      G + S ++  + S T
Sbjct: 1202 REELKQQKDDYNR-LQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1260

Query: 382  AAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
                  + +P  K TE ++     +  L  +   +      L       + KA + + + 
Sbjct: 1261 PG----LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316

Query: 442  EEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI- 500
            E+ E   K V+S + +L +  +E+ +LQE  +K   +   L+  +   E+  + L Q++ 
Sbjct: 1317 EKVELELK-VSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375

Query: 501  ------------RVLLMELEEARGNHVIRDEEVS--SADISSS--------SEVISQ--- 535
                        R L  +L+E +     ++E+VS  S  +S          +E+I Q   
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435

Query: 536  ----HLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE 591
                H       +E  ++ ++L V L E+ +  E   +E+ + +  ++Q KL++AL   +
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ--QIQRKLQAALISRK 1493

Query: 592  QL---RKSRQHQMQL--------------VDSIVRQRDMYR--------ILLSQTTGVAI 626
            +     KS Q ++ L              V+S V  ++  +        +L  +   +  
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLIT 1553

Query: 627  PLHASSLDDVSLAS------------TPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQ 674
             +  S L++ SL+S            T  +    + + +     + ESTE  E    L++
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613

Query: 675  LQEIF-ENYKKEKAENEKIQN------EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
              EI  ++Y+    E E+IQ+      ++ ++L  ++    +   +   QL  A +  E 
Sbjct: 1614 EYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673

Query: 728  LQDNVEGY----RREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAEN 783
            +++ +  +    +++I  L E N +L A             + L  +N           +
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA----------S 1723

Query: 784  LKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ-TIQG-ILERSETETKQRLSSQI 841
            +K+E E +K+    LS++ +SL++E+   +  + +L+  I+G + +++  E  ++  +Q 
Sbjct: 1724 MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT 1783

Query: 842  EKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEI 901
               E     +  + E E +     TR    + + + +  +   +   ++ + + N  ++I
Sbjct: 1784 NVTEEGTQSIPGETE-EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI 1842

Query: 902  ATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE---RLKTS 958
              LK+ ++ +E     +  Q+  +   + + + + L+SQ+   + ++  L+E   ++   
Sbjct: 1843 DQLKERIAGLE-----EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897

Query: 959  TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES----AEFQTQLEKKLMEVEKE 1014
               +++  + VT L+E+  +EK   EE   N    L  S     +  T  + K   +E E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957

Query: 1015 KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
             + L+       E  +Q + E  K  S ++ E  E +Q A     N+  A+ + QE  K 
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK-ELQELLKE 2016

Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
              +   + +++ + +   + AL+   + +  + +  Q   E T++  +Q +E       R
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE------HR 2070

Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE 1194
            ++   +  S  V   +   +  R+L D ++    K + S KE V+  +        K ++
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKL--KKELQSNKESVKSQM--------KQKD 2120

Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
            + LE       EK + E +    ++++LR R++V L E  + E+Q +LN + ++VQ   +
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALR-REKVHL-EETIGEIQVTLNKKDKEVQQLQE 2178

Query: 1255 TM-AQHEELMKKTETMNVVMETNKMLREEKERLEQD----LQQMQAKVRKLELDILPLQE 1309
             + +   +L   T++M+ + +    + +E ++ E+     +Q  + ++R  E +   L++
Sbjct: 2179 NLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238

Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS-QQKDPDT--EEYRKLLSEKEVHTK 1366
               ++S     L+     LE D + W+++ Q  V  QQK  DT   E ++LLS+ E    
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298

Query: 1367 RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQE 1426
                   E+ +L++E+      LT+  N ++  KE    +       + D+       ++
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ 2358

Query: 1427 KVKTITQVKKIGRRYKTQYEELKAQQDKVM-------ETSAQSSGDHQEQHVSVQEMQEL 1479
                +   +++  R    +EE+  ++ K++       E    +  + ++QH   +E++EL
Sbjct: 2359 LETDLQASRELTSRL---HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD--KEIKEL 2413

Query: 1480 KETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE 1539
            +  L+Q E ++  LE + +      ++     + ++++ +Q +++L    + +       
Sbjct: 2414 ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR 2473

Query: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI 1599
            +++     + EE+    I+     I   A   ++L +E   L+     L+ +  +LD  +
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533

Query: 1600 TALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
               +      I+  + + ++  E  L+Q  E +    K+ E+ ++
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578



 Score =  203 bits (516), Expect = 2e-51
 Identities = 388/1896 (20%), Positives = 755/1896 (39%), Gaps = 351/1896 (18%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRH----EKFKVESEQQYFEIEKRLSHSQERLVNETRE 74
            K +  K+E  +A+++     L+       E+F+ ++ Q   E+E R S  +++   E  E
Sbjct: 318  KILLEKMELEVAERKLSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQKHKAEMEE 376

Query: 75   CQSLRLELEKLNNQLKALTE--KNKELEIAQDRN-IAIQSQFT--RTKEELEAEKRDLIR 129
              S  L L+K   +L++  +  K++  ++ QD+N  A+QS  T  + +++L+ + +++ +
Sbjct: 377  KTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ 436

Query: 130  TNERL-----------------SQELEYLTED-VKRLNEKLKESNTTKGELQLKLDELQA 171
               RL                 ++  + +TE+ +  L +++ E    KG L L   EL+ 
Sbjct: 437  FLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELE- 495

Query: 172  SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
                       L+ E E L SQ T L  + +T          E   E+ E+       K 
Sbjct: 496  ----------ELKAENEKLSSQITLLEAQNRT---------GEADREVSEISIVDIANKR 536

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKS 291
              S  E   + L+ +     K +  LL ++KEA+E+ A ++ +   +     +       
Sbjct: 537  SSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK-----RAEEADHE 591

Query: 292  AADDSEAKSNELTR-AVEELHKLLKEAGE-----ANKAIQDHLLEVEQSKDQMEKEMLEK 345
              D  E K  E    A  ++   L++ G+      N+      +E EQ+  + +    E+
Sbjct: 592  VLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEE 651

Query: 346  IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVET 405
            I      L +A   L +TK+ G    ++ L+A+               +L  L +  +E 
Sbjct: 652  I-----SLNDAGVELKSTKQDG----DKSLSAVPDIGQCHQD------ELERLKSQILEL 696

Query: 406  QDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465
              +L   K + +   K LDE  KE+     +++  ++  +    A  +LS + +Q + ++
Sbjct: 697  --ELNFHKAQ-EIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753

Query: 466  QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
            + L   T+        L    +++E+ + +  +Q R   ++ E    +  +  E++ S  
Sbjct: 754  KELSMVTE--------LRAQVKQLEMNLAEAERQRR---LDYESQTAHDNLLTEQIHSLS 802

Query: 526  ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET---------TSSKI 576
            I + S+ +   ++    ++++Q Q       +R L    + +E E           SSK+
Sbjct: 803  IEAKSKDVKIEVLQ-NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861

Query: 577  TELQLKL---ESALTELEQLRKSRQHQMQLVDSIVRQRD--MYRILLSQT---------- 621
             EL   L   E  +T+++QL   ++  ++ +   + ++D  +  I  S T          
Sbjct: 862  EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921

Query: 622  --TGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIF 679
               GV I      L+ +S A   K+    +     + +       +   + + ++LQ  F
Sbjct: 922  FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981

Query: 680  ENYKKEKAE----------NEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQ 729
            +  KKE  +          N K   +++ +L+E++ +L+ ++ K     +      E  +
Sbjct: 982  DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK 1041

Query: 730  DNVEGYRREITS-LHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788
            +N E   + +TS   E    L  T  ++E  +  + +DL    EKLA  E     +K+  
Sbjct: 1042 ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL---EEKLAAEEQFQALVKQMN 1098

Query: 789  EML--KLSEVRLSQQRESLLAEQRG--QNLLLTNLQTIQGILERSETET----------- 833
            + L  K +++ L Q     ++E +   Q L+ +N     G       ET           
Sbjct: 1099 QTLQDKTNQIDLLQAE---ISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSS 1155

Query: 834  ---KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNT 890
               K  L  +I  LE E   L+KKL+  +  R  + +    +    + +L  + + +   
Sbjct: 1156 EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRL 1215

Query: 891  KELLKNAQKEIATLKQHLSNMEVQVA-----------SQSSQRTGKG------------- 926
            +E      KE   +   L  +++QV             Q S  +  G             
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275

Query: 927  ------------QPSNKED---------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQY 965
                         PS+ ED         V  + +QL++ E +  +L+ ++ ++TS + + 
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335

Query: 966  QAMVTSLEESLNKE-------KQVTEEVRKNIE--VRLKESAEFQTQLEKKLMEVEKEKQ 1016
               V  L+E +NK+       K V+ E   + E   +  ES++ Q    + L E++ +  
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395

Query: 1017 ELQ---DDKRRAIESMEQQLSELKKTLSSVQNEV--QEALQRASTALSNEQQARRD---- 1067
            ELQ     K   +  +  QLSE +  L+ +Q E+  QE L +A       Q    D    
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK 1455

Query: 1068 ------C---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS-------------- 1104
                  C   Q+  +I  E++ K + +  L AA +   +A KE  S              
Sbjct: 1456 QLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIER 1515

Query: 1105 ---KMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHD 1161
                +A V   +    ++ ++ L       EER++++  E+ + +   + L      L  
Sbjct: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI-TEMDRSLLENQSLSSSCESLKL 1574

Query: 1162 QIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVES 1221
             +E L++     VKE ++   +  ++E  + QE+  E    +++E EI    +E    E+
Sbjct: 1575 ALEGLTEDKEKLVKE-IESLKSSKIAESTEWQEKHKE----LQKEYEILLQSYENVSNEA 1629

Query: 1222 LRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKK-TETMNVVMETNKM-- 1278
             R +  VE + +E QEL   L +     + T K + + E+ M++  E M    ++ +   
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI 1689

Query: 1279 --LREEKERLEQDLQQMQAKVRKLELDILPLQEANAE-----------LSEKSGMLQAEK 1325
              L EE +RL  ++       ++    +L    +  E           LS+K   L +EK
Sbjct: 1690 LELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEK 1749

Query: 1326 KLLEEDVKRWKARNQHLVSQQKDPD-TEEYRKLLSEKEVHTKRIQQLTEE---------- 1374
              L E+V+  K + +  VS+Q + + TE++    +  E  T+ I   TEE          
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809

Query: 1375 --------------------------------IGRLKAEIARSNASLTNNQNLIQSLKED 1402
                                            I +LK  IA        N+   Q+L+ +
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869

Query: 1403 LNKVRTEKETIQKDLDAKII------------DIQEKVKTITQVKKIGRRYKTQYEELKA 1450
             N + ++  T  KD + K++             IQE++  +T++K+     K   EE   
Sbjct: 1870 KNTLLSQIST--KDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLM 1927

Query: 1451 QQDKVME----------TSAQSSGDHQEQHVS-----VQEMQELKETLNQAETKSKS--- 1492
             Q   +           T AQ   +  E  +      V E++E K+ L + +TK +S   
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987

Query: 1493 ---------------LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537
                            +S  + LQ+ L EK+ E + LQ+  ++ Q ++S L + ++    
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047

Query: 1538 QEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDV 1597
             + + ++ +   +E   +A+   K   A LA  K  L     E  +      + K EL  
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS 2107

Query: 1598 RITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
               ++KSQ + +   LER L + +E+HL+++   QE
Sbjct: 2108 NKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQE 2143



 Score =  195 bits (496), Expect = 4e-49
 Identities = 339/1650 (20%), Positives = 705/1650 (42%), Gaps = 219/1650 (13%)

Query: 56   EIEKRLSHSQERLVNETREC-----QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQ 110
            ++++RL+++ E+LV E ++        L+ + E L  + KA   K K+L++     +   
Sbjct: 49   DVQERLAYA-EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSL 107

Query: 111  SQFTRTKEELEAEKRDLIRTN----ERLSQELEYLTED---VKRLNEKLKESNTTKGELQ 163
            +++    EE++A+   ++ T     E+LS+  +  TE+   ++++  KL+E       LQ
Sbjct: 108  NKYI---EEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ 164

Query: 164  LKLDELQASDVSVKYRE--------KRLEQEKELLHSQNTWLN-TELKTKTDELLALGRE 214
             +L + QA   +    E        ++L++++E + +    L+ T+ +    +++   RE
Sbjct: 165  AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVV---RE 221

Query: 215  KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQ---QASM 271
            K       +  +   ++E+ +L  Q +        +Q+ +  L  KL+E +E    +A +
Sbjct: 222  KD---ARFETQVRLHEDELLQLVTQAD----VETEMQQKLRVLQRKLEEHEESLVGRAQV 274

Query: 272  EEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
             +    EL A  + + +        EA+ N L   VE       E  E+   ++   LEV
Sbjct: 275  VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET------EREESKILLEKMELEV 328

Query: 332  EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
             + K      + E++  L ++ E A    +  + + + L ++  A M    + +  + K 
Sbjct: 329  AERKLSFHN-LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387

Query: 392  GMKLTELYNAYVETQDQLLLEKLEN--------KRINKYLDEIVKEVEAKAPILKRQREE 443
            G +L    +A  +   +LL +K E         +++   L +  KE+      L  Q+ E
Sbjct: 388  GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447

Query: 444  YERAQKAVASLSVKLEQAMKE--IQRLQEDT-DKANKQSSVLERDNRRMEIQVKDLSQQI 500
               +Q +   +  +  QA+ E  I  LQ+   +  N++ ++L       E++ ++     
Sbjct: 448  -TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSS 506

Query: 501  RVLLMELEEARGNHVIRDEEVSSADI----SSSSEVISQHLVSYRNIEELQQQNQRLLVA 556
            ++ L+E +   G       E+S  DI    SSS+E   Q ++         Q+++ L V 
Sbjct: 507  QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLE----NTFSQKHKELSVL 562

Query: 557  LRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
            L E+ E +E         +I  L+L+L+    E        Q +M+ ++         ++
Sbjct: 563  LLEMKEAQE---------EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613

Query: 617  LLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
             L + TG   PL  +  ++ SL +  K  ++++  S  +     E     +A   LK  +
Sbjct: 614  FL-EDTGQDFPLMPN--EESSLPAVEKEQASTEHQSRTS-----EEISLNDAGVELKSTK 665

Query: 677  EIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYR 736
            +  +       +  +   ++LE+L+ Q+ +L         +L+F  K  E+ + N++   
Sbjct: 666  QDGDKSLSAVPDIGQCHQDELERLKSQILEL---------ELNF-HKAQEIYEKNLDEKA 715

Query: 737  REITSLHE-----------RNQKLTATTQKQEQIIN-----TMTQDLRGANEKLAVAEVR 780
            +EI++L++            +   TA +++++Q+++     +M  +LR   ++L +    
Sbjct: 716  KEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAE 775

Query: 781  AENLKK-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT----IQGILERSETETKQ 835
            AE  ++ + E     +  L++Q  SL  E + +++ +  LQ     +Q  L+ SE  T  
Sbjct: 776  AERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ--LQFSEQSTLI 833

Query: 836  R-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
            R L SQ++  E E+      LE     RH  ++  ++    ++++L+          +LL
Sbjct: 834  RSLQSQLQNKESEV------LEGAERVRHISSKVEELSQALSQKELEIT-----KMDQLL 882

Query: 895  KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954
               ++++ TL+Q +   + QV   S   T K    N+E    L  +++  +EQ+N L   
Sbjct: 883  LEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS-LGVEIKTLKEQLNLLSRA 941

Query: 955  LKTSTSNVEQYQAMVTSLEESLNKEKQV----TEEVRKNIEVRLKESAEFQTQLEKKLME 1010
             +     VE+   + + L+++ ++         EE++   ++  KE+ + + +L+  L+ 
Sbjct: 942  EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001

Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
                ++EL     R  E +     E KK +   + E  E  +       +E+     CQE
Sbjct: 1002 ----RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057

Query: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKAS 1130
                  +  ++ E EL     D+E   AA+EQ   +    + + +T Q   +Q+   +A 
Sbjct: 1058 IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALV---KQMNQTLQDKTNQIDLLQAE 1114

Query: 1131 WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ-GPLNVSLSEE 1189
              E + +++                 +L+    +      VA VKE V   P     SE 
Sbjct: 1115 ISENQAIIQ-----------------KLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157

Query: 1190 GKS--QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247
             K   +E+IL +      EKE                    E L+++LQE   S  A  +
Sbjct: 1158 WKPELEEKILAL------EKE-------------------KEQLQKKLQEALTSRKAILK 1192

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
            K Q   K     EEL ++ +  N + E      +E E +   L+Q+Q +VR+     LP 
Sbjct: 1193 KAQ--EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTK- 1366
             +     S   G+ +   K  E+         Q ++     PD   + +  S  +  T  
Sbjct: 1251 TDQQESCSSTPGLEEPLFKATEQH------HTQPVLESNLCPDWPSHSEDASALQGGTSV 1304

Query: 1367 -----RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE---TIQKDLD 1418
                 +++++  E   L+ +++ + + LT     +  L+E +NK   E E   T+  + +
Sbjct: 1305 AQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364

Query: 1419 AKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQE 1478
                 +Q+K+++ +Q++  G       E L+  Q K+ E     S   ++      ++ E
Sbjct: 1365 VHAESLQQKLES-SQLQIAG------LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417

Query: 1479 LKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQ 1538
             +  L + +T+    E  ++ L   L   E +A+   E+  QLQ EL  ++Q   +   +
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQL---EMQAKEHDERIKQLQVELCEMKQK-PEEIGE 1473

Query: 1539 EEQLRQQITEK-------EEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQ 1591
            E + +QQI  K        ++  K   + + +++   G  ++LTK   +++ +  A +++
Sbjct: 1474 ESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533

Query: 1592 KDELDVRITALKSQYEGRISRLERELREHQ 1621
            KD +  R+  L+ + +  I+ ++R L E+Q
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQ 1563



 Score =  152 bits (384), Expect = 4e-36
 Identities = 275/1346 (20%), Positives = 538/1346 (39%), Gaps = 196/1346 (14%)

Query: 6    QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESE--QQYFE------- 56
            Q V +    N+L +S    L+K +++ + E   L    EK KVESE  ++Y E       
Sbjct: 1942 QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV--KEKTKVESEIRKEYLEKIQGAQK 1999

Query: 57   ----------IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKAL----TEKNKELEIA 102
                      +++ L   Q+ +    ++C   + ++  L   +KAL    TE  K+LEI 
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059

Query: 103  QDRNIA----------------------IQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
            ++ N+A                       QS+  R   +    K++L    E +  +++ 
Sbjct: 2060 KE-NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118

Query: 141  LTEDVKRLNEKLKESNTT-KGELQLKLDELQAS-----------DVSVKYREKRLEQEKE 188
              ED++R  E+ +E +   K  +Q KLD L+              V++  ++K ++Q +E
Sbjct: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2178

Query: 189  LLHSQNTWLNTELKTKTDELLALGREKGNEILELKC-------NLENKKEEVSRLEEQMN 241
             L S  T    +L   T  + +L  ++   I E K         +++K+EE+   E+  +
Sbjct: 2179 NLDSTVT----QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234

Query: 242  GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
             LK     +  H+E+L   +   +  +   E K   E+        L +   D  + ++ 
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQ-------LQQKVCDTLQGENK 2287

Query: 302  ELTRAVEELHKL-------LKEAGEANKAIQDHLLEVEQS--KDQMEKEMLEKIGRLEKE 352
            EL   +EE   L       L +     K+++D L ++  S  K + +K  LE I R ++E
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR-QQE 2346

Query: 353  LENANDLLSATKRKGAILSEEELAA-----MSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
             +  N   S  + +  + +  EL +     ++     +  ++    +  ++  A +  Q 
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406

Query: 408  QLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR--EEYERAQKAVASLSVKLEQAMKEI 465
               +++LEN    +  + IV E E K  + K  +  E  +  +K       +L+  +K +
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466

Query: 466  QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
              LQ D D+       LE  +  + ++   L Q+      +L+E      IR       D
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE-----IRGLRSHMDD 2521

Query: 526  ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLES 585
            ++S +  +   L+ YR  E+L Q         ++L E + ++ +E   +K  +L+ KL+ 
Sbjct: 2522 LNSENAKLDAELIQYR--EDLNQVITIKDSQQKQLLEVQLQQNKEL-ENKYAKLEEKLKE 2578

Query: 586  ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRP 645
            +    E LR+S     +    + ++ +  ++ +SQ T     L       +  A    + 
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638

Query: 646  STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
                 +S      +  S++        K++ E+ E     + E  K   E  +KL++++ 
Sbjct: 2639 EEVHRLSA-----LFSSSQ--------KRIAELEEELVCVQKEAAKKVGEIEDKLKKELK 2685

Query: 706  DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
             L      +  + + A +R   L  ++    +++  + + N+ LTA  Q   + ++++  
Sbjct: 2686 HLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN 2745

Query: 766  DLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGI 825
                ANE+L   + + +   KE   LK  +  L+++R++LL+E                 
Sbjct: 2746 SRDHANEELDELKRKYDASLKELAQLK-EQGLLNRERDALLSETAF-------------- 2790

Query: 826  LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
               S   T++   S +EKL  ++  L K                D QLL    QL+   N
Sbjct: 2791 ---SMNSTEENSLSHLEKLNQQL--LSK----------------DEQLLHLSSQLEDSYN 2829

Query: 886  LHLNTKELLKNAQKEIATLKQHLSN-MEVQVASQSSQRTGKGQPSNKE-DVDDLVSQLRQ 943
               +  + + + Q E    + HL N +E    S+  ++    QPS    +V  L   +  
Sbjct: 2830 QVQSFSKAMASLQNE----RDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS 2885

Query: 944  TEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ 1003
             +   + L + LK       Q    +T L   L  + Q  ++  K  ++  +E  +    
Sbjct: 2886 LQNDRDRLLKELKNLQQQYLQINQEITELHP-LKAQLQEYQDKTKAFQIMQEELRQENLS 2944

Query: 1004 LEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
             + +L ++  EK   +  +RR  E     +S+  + LS +QN ++E    +S     + Q
Sbjct: 2945 WQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004

Query: 1064 ARRDCQEQAKIAVEAQNK--YERELMLHAAD--VEALQAAKEQVSKMASVRQHLEETTQK 1119
             +R    +   + +      YE EL+    +  ++ +   + ++ ++ S    L E    
Sbjct: 3005 YQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNT 3064

Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
               QL +   S  E ++   D ++ C      LEKQ                  V+E   
Sbjct: 3065 LSIQLCDTSQSLRENQQHYGDLLNHCAV----LEKQ------------------VQELQA 3102

Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETR-----FEVAQVESLRYRQRVELLERE 1234
            GPLN+ ++  G  QE+       + R+ +  E R     F  AQ +    RQ V  L + 
Sbjct: 3103 GPLNIDVA-PGAPQEK-----NGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156

Query: 1235 LQELQDSLNAEREKVQVTAKTMAQHE 1260
            L+E +D   A    + V  + + + E
Sbjct: 3157 LEEERDQRVAAENALSVAEEQIRRLE 3182



 Score =  130 bits (328), Expect = 1e-29
 Identities = 206/993 (20%), Positives = 425/993 (42%), Gaps = 152/993 (15%)

Query: 754  QKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ- 812
            Q+ +   N  TQ+     E+LA AE     LK   ++++  +V+L Q+ E+L  E++   
Sbjct: 36   QESDMEFNNTTQE--DVQERLAYAEQLVVELK---DIIRQKDVQLQQKDEALQEERKAAD 90

Query: 813  -----------------NLLLTNLQTIQGILERSETETKQRLSSQIEKL---EHEISHLK 852
                             N  +  ++   G +  +E +++++LS   +     E EI  +K
Sbjct: 91   NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIK 150

Query: 853  KKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNME 912
             KL+ + E   TL   L     +   Q  TE    +  K+ L+  ++ I+TL+  LS  +
Sbjct: 151  HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ 210

Query: 913  VQVASQS--SQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT 970
             + A+Q    ++  + +   +   D+L+  + Q + +  +++++L+     +E++     
Sbjct: 211  AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVET-EMQQKLRVLQRKLEEH----- 264

Query: 971  SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ-LEKKLMEVEKEKQELQ-------DDK 1022
              EESL    QV + +++ +      +AE + Q L ++L ++E E   L+       ++ 
Sbjct: 265  --EESLVGRAQVVDLLQQELT-----AAEQRNQILSQQLQQMEAEHNTLRNTVETEREES 317

Query: 1023 RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA--LSNEQQARRDCQEQAKIAVEAQN 1080
            +  +E ME +++E K +  ++Q E+   L++   A     E ++R    EQ K   E + 
Sbjct: 318  KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ-KHKAEMEE 376

Query: 1081 KYERELMLHAADVE---ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
            K    L L     E   A  A K+Q SK+   +   E+  Q A++         E++ + 
Sbjct: 377  KTSHILSLQKTGQELQSACDALKDQNSKLLQDKN--EQAVQSAQTI-----QQLEDQLQQ 429

Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV-KEGVQGPLNVSLSEEGK----- 1191
               E+S+ +         NRL   Q E  S      V  EG Q     +++   K     
Sbjct: 430  KSKEISQFL---------NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL 480

Query: 1192 SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ--DSLNAEREKV 1249
              E+   +L  I  E+  AE     +Q+  L  + R    +RE+ E+   D  N      
Sbjct: 481  ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540

Query: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE 1309
            + + + + ++    K  E   +++E    ++E +E +     Q+Q K R  E D   L +
Sbjct: 541  EESGQDVLENTFSQKHKELSVLLLE----MKEAQEEIAFLKLQLQGK-RAEEADHEVLDQ 595

Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
               +  E  G+   + K+  ED      ++  L+     P+ E     + +++  T+   
Sbjct: 596  KEMKQMEGEGIAPIKMKVFLEDT----GQDFPLM-----PNEESSLPAVEKEQASTEHQS 646

Query: 1370 QLTEEIG------RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTE-----------KET 1412
            + +EEI        LK+     + SL+   ++ Q  +++L +++++           +E 
Sbjct: 647  RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706

Query: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVM---------------- 1456
             +K+LD K  +I    + I + KK      + +  L  ++D+++                
Sbjct: 707  YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQV 766

Query: 1457 --------ETSAQSSGDHQEQ----HVSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
                    E   Q   D++ Q    ++  +++  L       + K + L+++++++Q   
Sbjct: 767  KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF 826

Query: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE---EKTRKAIVAAK 1561
            SE+ T  R+LQ Q    +SE+    + ++  +++ E+L Q +++KE    K  + ++  K
Sbjct: 827  SEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKK 886

Query: 1562 SKIAHLAGV---KD-QLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLEREL 1617
              +  L      KD Q+T+ +  + ++   L+++K  L V I  LK Q    +SR E   
Sbjct: 887  RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAK 945

Query: 1618 REHQERH------LEQRDEPQEPSNKVPEQQRQ 1644
            +E  E        L+Q  +   P+ ++ +++ Q
Sbjct: 946  KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978



 Score = 75.1 bits (183), Expect = 8e-13
 Identities = 94/458 (20%), Positives = 214/458 (46%), Gaps = 48/458 (10%)

Query: 1231 LERELQELQDSL--NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQ 1288
            L+ EL +  D    N  +E VQ   + +A  E+L+   E  +++ + +  L+++ E L++
Sbjct: 30   LDPELHQESDMEFNNTTQEDVQ---ERLAYAEQLV--VELKDIIRQKDVQLQQKDEALQE 84

Query: 1289 DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKD 1348
            + +    K++KL+L       A A+L+  +  ++ E K     V   + +++  +S+   
Sbjct: 85   ERKAADNKIKKLKL------HAKAKLTSLNKYIE-EMKAQGGTVLPTEPQSEEQLSKHDK 137

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA-----SLTNNQNLIQSLKEDL 1403
              TEE  ++  EK  H  ++Q+  E I  L+A++ ++ A     S T  +  +  +K+ L
Sbjct: 138  SSTEEEMEI--EKIKH--KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM-MKQQL 192

Query: 1404 NKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSS 1463
                 EKE     L A++   Q +      V++   R++TQ   ++  +D++++   Q+ 
Sbjct: 193  Q----EKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQ---VRLHEDELLQLVTQAD 245

Query: 1464 GDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
             + + Q    Q+++ L+  L + E         V+ LQ+ L+  E   + L +Q  Q+++
Sbjct: 246  VETEMQ----QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEA 301

Query: 1524 ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQ 1583
            E + LR  ++    + + L +++  +  + + +    + ++ HL    +Q  +   EL+ 
Sbjct: 302  EHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361

Query: 1584 RNGALDQQ-KDELDVRIT----------ALKSQYEGRISRLERELREHQERHLEQRDEPQ 1632
            R  AL+Q+ K E++ + +           L+S  +    +  + L++  E+ ++     Q
Sbjct: 362  RYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQ 421

Query: 1633 EPSNKVPEQQRQIT--LKTTPASGERGIASTSDPPTAN 1668
            +  +++ ++ ++I+  L   P       + TS P   N
Sbjct: 422  QLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN 459


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  207 bits (527), Expect = 1e-52
 Identities = 351/1642 (21%), Positives = 663/1642 (40%), Gaps = 189/1642 (11%)

Query: 145  VKRLNEKLKESNTTKGELQLKLDE----LQASDVSVKYREKRLEQ-----EKELLHSQNT 195
            ++RL ++L +  + + EL+L+L E    L   D  +   ++R+++     EK+       
Sbjct: 216  MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP 275

Query: 196  WLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE 255
                EL+ K + L     E   +  +LK        ++++L E+   L         H++
Sbjct: 276  KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335

Query: 256  DLLTKLKEAKEQQASMEEKF-------HNELNAHI---------------KLSNLYKSAA 293
             L   L E  E+ +   +++         EL+A +               KLS L +  +
Sbjct: 336  QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395

Query: 294  ---DDSEAKSNELTRAVEELHKLLKEAGEA---NKAIQDHLLEVEQSKDQMEKEMLEKIG 347
               D+   +  E+   V +L  L +EA      N  +Q  +  +E  + Q E ++L + G
Sbjct: 396  QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455

Query: 348  RLEKELENAN----DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYV 403
              E+E +  +    DL S+         E E A+ +  A   A++     +LT L NA +
Sbjct: 456  HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL-NATI 514

Query: 404  ETQDQLLLE-KLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
            + QDQ L   K + K     L + +++ E  +  L+ Q E+   + K       + EQ +
Sbjct: 515  QQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK-------QKEQQL 567

Query: 463  KEIQRLQEDTDK----------ANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELE-- 508
            KE+   QE T +            +++S+ ERD   +++E   K+ + ++ +L  +L+  
Sbjct: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627

Query: 509  -EAR--GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRE 565
             EAR      +   +   A++S   E + Q  V     E+ + Q Q   + L+   E ++
Sbjct: 628  NEARDSAQTSVTQAQREKAELSRKVEEL-QACVETARQEQHEAQAQVAELELQLRSEQQK 686

Query: 566  REEQETTSSKITELQLKLESALTELEQLRKS-RQHQMQLVDSIVRQRDMYRILLSQTTGV 624
              E+E  + +  +LQ +L++    L+  + S  + + +  D++  Q+     L ++T  +
Sbjct: 687  ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL 746

Query: 625  AIPLH---ASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFEN 681
             +  H      L++             Q          +   E  EA AA    +   E 
Sbjct: 747  -VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQ 805

Query: 682  YKKEKAE-NEKIQNEQLEK------LQEQVTDLRSQNTKISTQLDFASKRYEMLQDN--- 731
              KE A   E+ ++ Q E+       QEQ+  L+ +  K   +L  A ++   ++ +   
Sbjct: 806  LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865

Query: 732  -VEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE---VRAENLKKE 787
             +   + E+  LH    +     Q++E     +  DL    EK+A       R E L ++
Sbjct: 866  QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK 925

Query: 788  ---------KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLS 838
                     +E++K    R   ++   L EQ+G+    T     Q  L+  E E +Q + 
Sbjct: 926  AGEQQETASRELVK-EPARAGDRQPEWLEEQQGRQFCST-----QAALQAMEREAEQ-MG 978

Query: 839  SQIEKLEHEISHLKKKLENEVEQRH----TLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
            +++E+L   +   + + + E  Q+      LT+       D   +      L +  +  L
Sbjct: 979  NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038

Query: 895  KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954
               + E ATL++ L++   +   +  Q   K +      + +L  +LRQT   V  LKE+
Sbjct: 1039 NEQRVEFATLQEALAHALTEKEGK-DQELAKLRGLEAAQIKEL-EELRQT---VKQLKEQ 1093

Query: 955  LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE 1014
            L       +++ +   +  E+  +    TE     +E    E ++ + Q +K        
Sbjct: 1094 L---AKKEKEHASGSGAQSEAAGR----TEPTGPKLEALRAEVSKLEQQCQK-------- 1138

Query: 1015 KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
            +QE  D   R++E+     +E    L ++Q +++E  Q    + S    A+R+     + 
Sbjct: 1139 QQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL-AAFRT 1197

Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
             V+  +K E E     A        +++  +  S+   LEE       Q+LE +   +E 
Sbjct: 1198 KVQDHSKAEDEWKAQVA------RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251

Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE 1194
            +R++  E  K     + LE++ RLL  Q E  S+   A+ +         SL EE + Q 
Sbjct: 1252 KRLVMAESEK----SQKLEERLRLL--QAETASNSARAAERSSALREEVQSLREEAEKQR 1305

Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
               E L   R+E      R E    E   ++++    E+ L  LQ     E    Q    
Sbjct: 1306 VASENL---RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ----LEHTSTQALVS 1358

Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL---DILPLQEAN 1311
             +   + L ++ +      E  K  REE E+ +Q    ++A++ + +    +++PL++  
Sbjct: 1359 ELLPAKHLCQQLQAEQAAAE--KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKV 1416

Query: 1312 AELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQL 1371
            AE    +  L+AEK    E +   K  +  L  + +       R  L  + +  +  Q  
Sbjct: 1417 AEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGE---RANLGRQFLEVELDQAR 1473

Query: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN-----------KVRTEKETIQKD---L 1417
             + +  L A  A +   L   Q   QS   +L            KV  E++  Q++   L
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKL 1533

Query: 1418 DAKI--IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE 1475
             A++  +++ ++ +T  QV+++ ++     +  K QQ K+    AQ     QE      +
Sbjct: 1534 TAQVEQLEVFQREQT-KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592

Query: 1476 MQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQ---TVQLQSELSRLRQDL 1532
            + EL+  L+Q E  ++  + Q+E  +     K+ + + LQEQ     QLQ E   LR + 
Sbjct: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEA 1652

Query: 1533 QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK------ENEELKQRNG 1586
            +    + +Q   +  E E+  R      +S  A +A    QL          + LK R  
Sbjct: 1653 ERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE- 1711

Query: 1587 ALDQQKDELDVRITALK-SQYEGRISRLERELREHQERHLEQRDEPQEP-SNKVP---EQ 1641
               Q K +LD+ I +L  S  EG    +  +L   Q        EP  P S ++P   E 
Sbjct: 1712 --PQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVES 1769

Query: 1642 QRQITLKTTPASGERGIASTSD 1663
               +     PA  +  + S+ D
Sbjct: 1770 LESLYFTPIPARSQAPLESSLD 1791



 Score =  195 bits (496), Expect = 4e-49
 Identities = 316/1567 (20%), Positives = 643/1567 (41%), Gaps = 182/1567 (11%)

Query: 29   LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE---RLVNETRECQSLRLELEKL 85
            +A  Q  ID L   +EK +  S  +  E+E+    ++    RL    ++CQ L+ E  ++
Sbjct: 251  IAMMQQRIDRLALLNEK-QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQM 309

Query: 86   NNQLKALTEKNKELEIAQDRNIA-----IQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
            + ++  L+E+N +L   + R  A     +Q       EE     ++ +    +L +EL  
Sbjct: 310  DRKINQLSEENGDLSF-KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA 368

Query: 141  LTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK-------YREKRLEQEKELLHSQ 193
              +D K L EK +       +L+  L +LQ +    K        + + L+QE   L + 
Sbjct: 369  ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428

Query: 194  NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKH 253
            NT L   ++        L  E+G +  +L     + +EE  +L   +  L++S       
Sbjct: 429  NTQLQARVE-------MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS------- 474

Query: 254  VEDLLTKLKEAKEQQASMEEKFHNELNAHI-----KLSNLYKSAADDSEAKSNELTRAVE 308
                ++ L +AKE+     +     L A +     +L+ L  +     +  +    +A E
Sbjct: 475  ----ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE 530

Query: 309  ---ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLE-KELENANDLLSATK 364
               +L + L++  +A++ ++  + ++  S  Q E+++ E   + E    ++A  L +A +
Sbjct: 531  KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590

Query: 365  RKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLD 424
             + A L E + A     A    K  K  +   +L  A  E +D       + +R    L 
Sbjct: 591  EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN-EARDSAQTSVTQAQREKAELS 649

Query: 425  EIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLER 484
              V+E++A    ++  R+E   AQ  VA L         E+Q   E      K+    E+
Sbjct: 650  RKVEELQA---CVETARQEQHEAQAQVAEL---------ELQLRSEQQKATEKERVAQEK 697

Query: 485  DNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSS-EVISQHLVSYRNI 543
            D  + ++Q    S ++    +E E+ R    + +++   +++ + +  ++ QH    + +
Sbjct: 698  DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKEL 757

Query: 544  EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQL 603
            EE +   + L   L++LGE  +  E E    ++ E      +A +E EQL K      + 
Sbjct: 758  EEERAGRKGLEARLQQLGEAHQ-AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816

Query: 604  VDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST 663
             +   ++   Y  +                + +         +  +       V  IES 
Sbjct: 817  YEDSQQEEAQYGAMFQ--------------EQLMTLKEECEKARQELQEAKEKVAGIESH 862

Query: 664  EAIEAKAALKQLQEIFENYKK------EKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ 717
              ++      +L E+  N  +      EK    +   + L  LQE++     +  ++ T 
Sbjct: 863  SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922

Query: 718  LDFASKRY-----EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
            +  A ++      E++++      R+   L E+  +   +TQ   Q +    + +    E
Sbjct: 923  VRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELE 982

Query: 773  KLAVAEVRAENLKKEKEMLKLSEVRLSQQRE-SLLAEQRGQNLLLTNLQTIQGILERSET 831
            +L  A + ++  ++E+        R  Q+RE + L ++RG+       Q    + + +  
Sbjct: 983  RLRAALMESQGQQQEE--------RGQQEREVARLTQERGR------AQADLALEKAARA 1028

Query: 832  ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTK 891
            E + RL + + +   E + L++ L + + ++    + L         Q+     L    K
Sbjct: 1029 ELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVK 1088

Query: 892  ELLKN-AQKEIATLKQHLSNMEVQ-VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
            +L +  A+KE    K+H S    Q  A+  ++ TG    + + +V  L  Q ++ +EQ +
Sbjct: 1089 QLKEQLAKKE----KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144

Query: 950  DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
             L+  L+   ++  +  + + +L+  L ++ Q     +  +    +E A F+T+++    
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK 1204

Query: 1010 EVEKEKQELQDDKRRA------IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
              ++ K ++   ++ A      I S+E+++S L + +   + E +E L+R   A S + Q
Sbjct: 1205 AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE-LKRLVMAESEKSQ 1263

Query: 1064 ARRDCQE--QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE 1121
               +     QA+ A  +    ER   L        + A++Q     ++RQ L    ++AE
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323

Query: 1122 SQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGP 1181
                E KA W+E+                  +K+  L   Q+E  S + + S     +  
Sbjct: 1324 ELGQELKA-WQEK----------------FFQKEQALSTLQLEHTSTQALVSELLPAK-- 1364

Query: 1182 LNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELL--ERELQEL- 1238
                L ++ ++++   E     +R +E      E+ Q +      R ELL  +REL EL 
Sbjct: 1365 ---HLCQQLQAEQAAAE-----KRHRE------ELEQSKQAAGGLRAELLRAQRELGELI 1410

Query: 1239 ---QDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQA 1295
               Q     ER   Q+ A+  +  E+L    +   ++ E N+ L E      Q L+    
Sbjct: 1411 PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD 1470

Query: 1296 KVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-VSQQKDPDTEEY 1354
            + R+  +  L    A+AE        +A+    E +V   K     + V +++    EE 
Sbjct: 1471 QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530

Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
            +KL ++ E      ++ T+++  L  ++A S+ +    Q  +++++    + + E + +Q
Sbjct: 1531 QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590

Query: 1415 KDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
              L+       E    ++Q ++    YK Q E+ K   D   + +              Q
Sbjct: 1591 AQLN-------ELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQN--------------Q 1629

Query: 1475 EMQELKETLNQAETKSKSLESQVENL-----QKTLSEKETE--ARNLQEQTVQLQSELSR 1527
            E+QE   +L Q + ++K L ++ E L     Q  L  KE E   R+L  Q   L+++++ 
Sbjct: 1630 ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH 1689

Query: 1528 LRQDLQD 1534
              Q L+D
Sbjct: 1690 ADQQLRD 1696



 Score =  176 bits (447), Expect = 2e-43
 Identities = 331/1601 (20%), Positives = 662/1601 (41%), Gaps = 226/1601 (14%)

Query: 52   QQYFEIEKRLSHSQERLVNETRECQS-LRLELEKLNNQLKALTEKNKELEIAQDRNIAIQ 110
            QQ  +    L+    +   E  E Q+ L  EL       K L EKN   EI Q +   ++
Sbjct: 335  QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKN---EILQGKLSQLE 391

Query: 111  SQFTRTKEELEAEKRDL---IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL- 166
               ++ ++    EK ++   +   E L QE   L  +  +L  +++   T +G+ + KL 
Sbjct: 392  EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLL 451

Query: 167  -----------------DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELL 209
                              +LQ+S  ++   ++ LEQ  +   +    L  ++ + T EL 
Sbjct: 452  AERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQ---AHGARLTAQVASLTSELT 508

Query: 210  ALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
             L      +  EL    +  KE+ ++L + +   + +++ L+  VE L + LK+ ++Q  
Sbjct: 509  TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568

Query: 270  SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLL 329
             + EK       H   +    +AA++ EA   E   A+++L  L KE     + +Q  L 
Sbjct: 569  EVAEKQEATRQDH---AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ 625

Query: 330  EVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE--EELAAMSPTAAAVAK 387
               +++D                  +A   ++  +R+ A LS   EEL A   TA     
Sbjct: 626  VANEARD------------------SAQTSVTQAQREKAELSRKVEELQACVETARQEQH 667

Query: 388  IVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERA 447
              +  +   EL    + ++ Q   EK   +R+ +  D++ ++++A    LK  +   E  
Sbjct: 668  EAQAQVAELEL---QLRSEQQKATEK---ERVAQEKDQLQEQLQALKESLKVTKGSLEEE 721

Query: 448  QKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQ-IRVLLME 506
            ++  A    + ++ + E+        KA  +S V +    R E++ +   ++ +   L +
Sbjct: 722  KRRAADALEEQQRCISEL--------KAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773

Query: 507  LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER 566
            L EA             A+       +++ + +    E   +Q  + + A RE  E  ++
Sbjct: 774  LGEAH-----------QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822

Query: 567  EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAI 626
            EE +  +       +  E  +T  E+  K+RQ   +  + +        + +S+      
Sbjct: 823  EEAQYGA-------MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELA 875

Query: 627  PLHAS---SLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYK 683
             LHA+   +L  V      +    +  +ST        S E    +  +++  E  E   
Sbjct: 876  ELHANLARALQQVQ-EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934

Query: 684  KEKA-ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSL 742
            +E   E  +  + Q E L+EQ      Q       L    +  E + + +E  R    +L
Sbjct: 935  RELVKEPARAGDRQPEWLEEQ---QGRQFCSTQAALQAMEREAEQMGNELERLR---AAL 988

Query: 743  HERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE-VRAENLKKEKEMLKLSEVRLSQQ 801
             E   +      +QE+ +  +TQ+   A   LA+ +  RAE   + +  L    V  +  
Sbjct: 989  MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048

Query: 802  RESL---LAEQRGQNLLLTNL---------------QTIQGILERSETETKQRLSS---- 839
            +E+L   L E+ G++  L  L               QT++ + E+   + K+  S     
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108

Query: 840  ------------QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQ----------LLDTK 877
                        ++E L  E+S L+++ + + EQ  +L R+L+ +          L   +
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ 1168

Query: 878  RQLDTETNLHLNTKELLKNAQKEIATLKQHLSN-------MEVQVA--SQSSQRTGKGQP 928
             QL+ +     +++  L +AQ+E+A  +  + +        + QVA   Q ++R      
Sbjct: 1169 GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228

Query: 929  SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE-ESLNKEKQVTEE-- 985
            S +E+V  L  Q+ + E +  +LK  +   +   ++ +  +  L+ E+ +   +  E   
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288

Query: 986  -VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQ 1044
             +R+ ++  L+E AE Q    + L +    + E  ++  + +++ +++  + ++ LS++Q
Sbjct: 1289 ALREEVQ-SLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ 1347

Query: 1045 NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAAD---VEALQAAKE 1101
             E        S  L  +   ++   EQA  A E +++ E E    AA     E L+A +E
Sbjct: 1348 LEHTSTQALVSELLPAKHLCQQLQAEQA--AAEKRHREELEQSKQAAGGLRAELLRAQRE 1405

Query: 1102 QVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD------EVSKCVCRCEDLEKQ 1155
             + ++  +RQ + E  + A+ QL   KAS+ E+  MLK       E ++ +    +L +Q
Sbjct: 1406 -LGELIPLRQKVAEQERTAQ-QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQ 1463

Query: 1156 NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFE 1215
               L  ++++  +K V  +   V+      L+E  +  +          RE E+   ++E
Sbjct: 1464 --FLEVELDQAREKYVQEL-AAVRADAETRLAEVQREAQS-------TARELEVMTAKYE 1513

Query: 1216 VAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA-QHEELMKK----TETMN 1270
             A+V+ L  RQR        QE +  L A+ E+++V  +    Q EEL KK     +   
Sbjct: 1514 GAKVKVLEERQR-------FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASK 1566

Query: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
            V  +  K ++ +    +Q+ Q++QA++ +L+      Q +  E + +   LQ EK     
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQ-----AQLSQKEQAAEHYKLQMEKAKTHY 1621

Query: 1331 DVKRWKARNQHLVSQQKDPD--TEEYRKLLSEKE----------VHTKRIQQ----LTEE 1374
            D K  K +NQ L  Q +  +   +E ++L +E E          + TK  +Q    LT +
Sbjct: 1622 DAK--KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ 1679

Query: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQ-EKVKTITQ 1433
            +  L+A++A ++  L +       +  D  K R  +   Q DL    +D+  E+   ++ 
Sbjct: 1680 VRSLEAQVAHADQQLRDLGKF--QVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSI 1737

Query: 1434 VKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493
              K+ R           Q D        +S   Q     V+ ++ L  T   A +++  L
Sbjct: 1738 TSKLPR----------TQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQA-PL 1786

Query: 1494 ESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD 1534
            ES +++L     +   + R+ + +T Q+ +     + D+++
Sbjct: 1787 ESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEE 1827



 Score =  145 bits (365), Expect = 6e-34
 Identities = 241/1288 (18%), Positives = 538/1288 (41%), Gaps = 165/1288 (12%)

Query: 2    AAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKV---ESEQQYFEIE 58
            A + QQ  E   L +  K  Q +L + L  Q+    GL+ + E+      + EQQ  E+ 
Sbjct: 512  ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571

Query: 59   K-----RLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN--------KELEIAQDR 105
            +     R  H+Q+ L     E ++   E +    QL+AL ++         ++L++A + 
Sbjct: 572  EKQEATRQDHAQQ-LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630

Query: 106  NIAIQSQFTRTK----------EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKES 155
              + Q+  T+ +          EEL+A      +       ++  L   ++   +K  E 
Sbjct: 631  RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690

Query: 156  NTTKGELQLKLDELQASDVSVKYREKRLEQEK----ELLHSQNTWLNTELKTKTDELLAL 211
                 E     ++LQA   S+K  +  LE+EK    + L  Q   + +ELK +T  L+  
Sbjct: 691  ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAETRSLVEQ 749

Query: 212  GREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLL-------TKLKEA 264
             + +  E+ E +     +K   +RL++     +   E L++ + + +       ++ ++ 
Sbjct: 750  HKRERKELEEERA---GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQL 806

Query: 265  KEQQASMEEKFHNELNAHIKLSNLYK----SAADDSEAKSNELTRAVE-----ELHKLLK 315
             ++ A+  E++ +      +   +++    +  ++ E    EL  A E     E H  L+
Sbjct: 807  VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ 866

Query: 316  EAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEEL 375
             + + N+  + H       +   EKE+  +  +L  +L    + ++AT ++ A L     
Sbjct: 867  ISRQQNELAELHANLARALQQVQEKEV--RAQKLADDLSTLQEKMAATSKEVARLETLVR 924

Query: 376  AAMSPTAAAVAKIVKPGMKLTELYNAYVETQD--QLLLEKLENKRINKYLDEIVKEVE-A 432
             A      A  ++VK   +  +    ++E Q   Q    +   + + +  +++  E+E  
Sbjct: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984

Query: 433  KAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQ 492
            +A +++ Q ++ E           +  Q  +E+ RL ++  +A    ++ +     +E++
Sbjct: 985  RAALMESQGQQQE-----------ERGQQEREVARLTQERGRAQADLALEKAARAELEMR 1033

Query: 493  VKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQR 552
            +++   + RV    L+EA   H + ++E    ++   +++        + +EEL+Q  ++
Sbjct: 1034 LQNALNEQRVEFATLQEALA-HALTEKEGKDQEL---AKLRGLEAAQIKELEELRQTVKQ 1089

Query: 553  L--LVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQ 610
            L   +A +E         Q   + +      KLE+   E+ +L +  Q Q +  DS+ R 
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149

Query: 611  RDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKA 670
             +  R                       AS  +R S  +T+         ++ E   +++
Sbjct: 1150 LEAER-----------------------ASRAERDSALETLQGQLEE---KAQELGHSQS 1183

Query: 671  ALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKIST---QLDFASKRYEM 727
            AL   Q     ++ +  ++ K ++E   ++     +   +N+ IS+   ++   +++   
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243

Query: 728  LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
             +   +  +R + +  E++QKL    +  +    T +   R A    A+ E   ++L++E
Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQ--AETASNSARAAERSSALRE-EVQSLREE 1300

Query: 788  KEMLKLSEVRLSQQRESLL--AEQRGQNLLLTNLQTIQ-----GILERSETETKQRLSSQ 840
             E  +++   L Q+  S    AE+ GQ L     +  Q       L+   T T+  +S  
Sbjct: 1301 AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360

Query: 841  I------EKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
            +      ++L+ E +  +K+   E+EQ       L  +LL  +R+L     L     E  
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420

Query: 895  KNAQK---EIATLKQHLSNMEVQVASQSSQRTGKGQPSN--------------KEDVDDL 937
            + AQ+   E A+  + LS ++      + +  G G+ +N              ++ V +L
Sbjct: 1421 RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480

Query: 938  VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +     E ++ +++   +++   +E   A     +  + +E+Q  +E R+ +  ++++ 
Sbjct: 1481 AAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540

Query: 998  AEFQTQLEKKLMEVEK------EKQELQDDKRRAIES-----------MEQQLSELKKTL 1040
              FQ +  K++ E+ K      +  ++Q  K +A+++           ++ QL+EL+  L
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600

Query: 1041 SSVQNEVQE---ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQ 1097
            S  +   +     +++A T    ++Q  ++ QEQ + ++E   K  +EL    A+ E L 
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR-SLEQLQKENKEL---RAEAERLG 1656

Query: 1098 AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNR 1157
               +Q        +  E+T +   +Q+   +A     ++ L+D + K     + L+ +  
Sbjct: 1657 HELQQAGLKT---KEAEQTCRHLTAQVRSLEAQVAHADQQLRD-LGKFQVATDALKSREP 1712

Query: 1158 LLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
                Q++   D +  S +EG   PL+++
Sbjct: 1713 QAKPQLDLSIDSLDLSCEEGT--PLSIT 1738


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  206 bits (525), Expect = 2e-52
 Identities = 288/1409 (20%), Positives = 601/1409 (42%), Gaps = 173/1409 (12%)

Query: 296  SEAKSNELTRAVEELHKLLKEAG---EANKAIQ-DHLLEVEQSKDQMEKEMLEK---IGR 348
            S   ++EL +  E +H    ++G   E+N A++ D +  + Q    ++  + E+      
Sbjct: 49   SLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEE 108

Query: 349  LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
            L+KELE    L     +   ++++   A +      + +       + ++ + + +   Q
Sbjct: 109  LKKELEKYQGLQQQEAKPDGLVTDSS-AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167

Query: 409  LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL 468
            L  E  + K  +KY +E               R   E A++ V  L+ +L +    IQ L
Sbjct: 168  LATEIADIK--SKYDEE---------------RSLREAAEQKVTRLTEELNKEATVIQDL 210

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLL--MELEEARGNHVIRDEEVSSADI 526
            + +         +L+R        +K    Q++ L+  M LE  R +  ++DE       
Sbjct: 211  KTE---------LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261

Query: 527  SSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSK-ITELQLKLES 585
             +SSE     L S     EL +  Q + V ++EL + +    + T  ++ +TE  LK E 
Sbjct: 262  YASSEATISQLRS-----ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316

Query: 586  ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRP 645
              T+LE+         + + + + Q+D    L  Q     +    +SL  + +  + K  
Sbjct: 317  DYTKLEEKHNEESVSKKNIQATLHQKD----LDCQQLQSRLSASETSLHRIHVELSEKGE 372

Query: 646  STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
            +T +     + V     T+    KA  KQLQ+  E  ++   + +   N+   KL E   
Sbjct: 373  ATQKLKEELSEV----ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428

Query: 706  DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER-NQKLTATTQKQEQIINTMT 764
             L   + ++  Q   +S++    +  V   + +++ L E+  +K+T +T+ Q Q+  T  
Sbjct: 429  QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488

Query: 765  QDL------RGANEKLAVAEVRAENLKKE----KEMLKLSEVRLSQQRESLLAEQRGQNL 814
            Q        +    KL  A+   E + ++     + ++  E  L + +E++   ++ +  
Sbjct: 489  QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548

Query: 815  LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
            L   +Q  +G     ET    +L  +   L+ +++ L +KL+N+ E       NL  Q+ 
Sbjct: 549  LYAKIQAGEG-----ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603

Query: 875  DTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDV 934
            + K  L    +  L+ +  +     ++   K+ +S +++Q+ +++       + +     
Sbjct: 604  EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS-AEAAKTAQR 662

Query: 935  DDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRL 994
             DL + L   +  + D ++ L   T+ ++Q  A +   +E  ++           +E  L
Sbjct: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-----------LESHL 711

Query: 995  KESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054
            KE  E    LE+K  E+E + ++L+ D      S EQ L +L++     Q ++   L+  
Sbjct: 712  KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-----QRQLNTDLELR 766

Query: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
            +T LS + +  ++     ++ ++ ++             EAL++ K++++K    +Q L+
Sbjct: 767  ATELSKQLEMEKEIVSSTRLDLQKKS-------------EALESIKQKLTKQEEEKQILK 813

Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
               Q  E+   E K   EE    L + +   V   + ++ +   L  ++  + DK+ + V
Sbjct: 814  ---QDFETLSQETKIQHEE----LNNRIQTTVTELQKVKMEKEALMTELSTVKDKL-SKV 865

Query: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234
             + ++   +    E  K +  IL++      EK   E + ++        + ++E   +E
Sbjct: 866  SDSLKNSKSEFEKENQKGKAAILDL------EKTCKELKHQL--------QVQMENTLKE 911

Query: 1235 LQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293
             +EL+ SL  E+E   Q+  +  +  E+L++   T+    +  + L+     L+Q  +Q 
Sbjct: 912  QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971

Query: 1294 QAKVRKL--ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT 1351
            + ++  L  EL I  LQ+   E   +  + QA ++L  E  K    +N +  SQ      
Sbjct: 972  KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ------ 1025

Query: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE 1411
            E +++L S+       +    +++  ++ +++ +   L +N+N I +  + + +++T K 
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085

Query: 1412 TIQKDLDAKIIDIQEKVKTITQVKK---------IGRRYK-TQYEELKAQQDKVMETSAQ 1461
            T+++D   K   +QE+ K +  ++K         +  + K  + EE+K +Q+K +    +
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145

Query: 1462 SSGDHQEQHVS-VQEMQELKETLNQAET----KSKSLESQVENLQKTLS--------EKE 1508
                H+ + +  +  +++ K+ L Q +     K+ SL++ VE  ++           E+E
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205

Query: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLA 1568
               +   E+  +L SE+      ++     E +L  QIT   E              +L 
Sbjct: 1206 ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE--------------NLG 1251

Query: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQR 1628
             VK    KE +  ++R   L++Q D+L   I  L    E  +   + E R   ER L+  
Sbjct: 1252 TVK----KEWQSSQRRVSELEKQTDDLRGEIAVL----EATVQNNQDERRALLERCLKGE 1303

Query: 1629 DEPQEPSNKVPEQQRQITLKTTPASGERG 1657
             E ++   KV E QR++   TT A  E G
Sbjct: 1304 GEIEKLQTKVLELQRKLD-NTTAAVQELG 1331



 Score =  201 bits (512), Expect = 5e-51
 Identities = 286/1324 (21%), Positives = 577/1324 (43%), Gaps = 160/1324 (12%)

Query: 199  TELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN----EHLQKHV 254
            T L+ +  +L A  +E+     ELK  LE K + + + E + +GL T +    + L++ +
Sbjct: 86   TLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144

Query: 255  EDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLL 314
            E+  T+    K+ +   E+K          + + Y       EA   ++TR  EEL+K  
Sbjct: 145  EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK-- 202

Query: 315  KEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS----ATKRKGAIL 370
                EA   IQD   E+      +++  +E +  L+KEL     L+       +R+   L
Sbjct: 203  ----EAT-VIQDLKTEL------LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251

Query: 371  SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
             +E     S  A++ A I       ++L +   +   ++ +   E +++   ++E+ ++ 
Sbjct: 252  KDECKKLQSQYASSEATI-------SQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304

Query: 431  EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME 490
            +     L ++ ++Y + ++     SV  +     + +   D  +   + S  E    R+ 
Sbjct: 305  QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364

Query: 491  IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
            +++ +  +  + L  EL E    +  +  +     +    E   QH +  ++  E+ Q +
Sbjct: 365  VELSEKGEATQKLKEELSEVETKY--QHLKAEFKQLQQQREEKEQHGLQLQS--EINQLH 420

Query: 551  QRLLVALRELGET--REREEQETTSSK-------ITELQLKLESALTEL-EQLRKSRQHQ 600
             +LL   R+LGE   R +E+++ +S K       + +LQLKL     +L E++  S + Q
Sbjct: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480

Query: 601  MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660
             QL     +Q+   +  L Q+T   +    + L+ V      K                I
Sbjct: 481  HQL--DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK-------------I 525

Query: 661  ESTEAI--EAKAALKQLQEIFENY--KKEKAENEKIQNEQLEK----LQEQVTDLRSQNT 712
            ++ EA+  ++K  +  L++  E+   K +  E E     QL++    LQEQVT L     
Sbjct: 526  QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL---TE 582

Query: 713  KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
            K+  Q +   +  E L D V+  +  + +  +R   L       E  +N +   L  + E
Sbjct: 583  KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL-------ETSVNELNSQLNESKE 635

Query: 773  KLAVAEVRAENLKKEKEMLKLSEVRLSQQR-----------ESLLAEQRGQNLLLTNLQT 821
            K++  +++   +K + E+L  +E   + QR            +L  +Q+  N + T L  
Sbjct: 636  KVSQLDIQ---IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692

Query: 822  IQGILERSETETKQ--------------------RLSSQIEKLEH---EISHLKKKLENE 858
            +   L+  +    Q                     L  QI+KLE    E+   K++   +
Sbjct: 693  VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752

Query: 859  VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVA 916
            ++Q+  L  +L+++  +  +QL+ E  +  +T+  L+   + + ++KQ L+    E Q+ 
Sbjct: 753  LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812

Query: 917  SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT-SLEES 975
             Q  +   +      E++++ +       ++V   KE L T  S V+   + V+ SL+ S
Sbjct: 813  KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872

Query: 976  ---LNKEKQVTEEVRKNIEVRLKE-SAEFQTQLEKKLMEVEKEKQELQDDKRRA------ 1025
                 KE Q  +    ++E   KE   + Q Q+E  L E ++ K+ L+ +K  +      
Sbjct: 873  KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932

Query: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD---CQEQAKIAV----EA 1078
            + SM++QL + + TL   + E Q+     +    + +Q ++     Q + KIAV    E 
Sbjct: 933  LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992

Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERML 1138
            +NK +++L   A   + L A KE++S + +  +  +ET ++ +S     ++      + L
Sbjct: 993  ENKLQQQLTQAA---QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL 1049

Query: 1139 KDEVSKCVCRCEDLEKQNRLLHDQIEKLSD-KVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
            K    K     EDL      + +Q + + + K   +  E         L E  K+ + I 
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109

Query: 1198 EILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER-EKVQVTAKTM 1256
            +      +EKE+   + ++A++E ++ RQ     E+E+ +L + L + + E ++      
Sbjct: 1110 KEKSL--KEKELVNEKSKLAEIEEIKCRQ-----EKEITKLNEELKSHKLESIKEITNLK 1162

Query: 1257 AQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSE 1316
               + L+++   +    ++ K   E+++R +Q L+    +V+K E      +E   E  E
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD---QVKKEE------EELKKEFIE 1213

Query: 1317 KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376
            K   L +E K  E  +K+ +  N+  ++ Q     E    +  E +   +R+ +L ++  
Sbjct: 1214 KEAKLHSEIKEKEVGMKKHE-ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272

Query: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKV-KTITQVK 1435
             L+ EIA   A++ NNQ+  ++L E   K   E E +Q     K++++Q K+  T   V+
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ----TKVLELQRKLDNTTAAVQ 1328

Query: 1436 KIGR 1439
            ++GR
Sbjct: 1329 ELGR 1332



 Score =  186 bits (472), Expect = 2e-46
 Identities = 267/1363 (19%), Positives = 590/1363 (43%), Gaps = 142/1363 (10%)

Query: 255  EDLLTKLKEAKEQQASM-EEKFHNELNAHIKLSNLYKSAADDSEAKSNEL-TRAVEELHK 312
            +D+    +E ++ QAS+ EEK+++E    +K            EAK + L T +  EL  
Sbjct: 83   DDVTLLRQEVQDLQASLKEEKWYSE---ELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139

Query: 313  LLKEAGEANKAIQDHLLEVEQSKDQMEK---EMLEKIGRLEKELENANDLLSATKRKGAI 369
            L ++  EA    Q     ++Q KD  E+   ++  +I  ++ + +    L  A ++K   
Sbjct: 140  LEQQLEEA----QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195

Query: 370  LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429
            L+EE    ++  A  +  +       TEL       +D  +L+K E  ++   +D +  E
Sbjct: 196  LTEE----LNKEATVIQDLK------TELLQR-PGIEDVAVLKK-ELVQVQTLMDNMTLE 243

Query: 430  VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
             E ++  LK   +E ++ Q   AS    + Q   E+        K  ++ +V  ++ +++
Sbjct: 244  RERESEKLK---DECKKLQSQYASSEATISQLRSELA-------KGPQEVAVYVQELQKL 293

Query: 490  EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
            +  V +L+Q+ + L   L +   ++   +E+ +   +S  +   + H     + ++LQ +
Sbjct: 294  KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL-DCQQLQSR 352

Query: 550  NQ-------RLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
                     R+ V L E GE  ++ ++E     ++E++ K +    E +QL++ R+ + Q
Sbjct: 353  LSASETSLHRIHVELSEKGEATQKLKEE-----LSEVETKYQHLKAEFKQLQQQREEKEQ 407

Query: 603  LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
                +  + +     L +T       H    +   L+S        Q       +  +E 
Sbjct: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467

Query: 663  TEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFAS 722
             +  E      +LQ   +  K++  E + +Q     KL+E   DL     ++  Q+    
Sbjct: 468  -QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE----QVLRQIGDKD 522

Query: 723  KRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR-A 781
            ++ + L+  ++  +  I+ L +  + L A  Q  E     + Q L+  N  L     +  
Sbjct: 523  QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLT 581

Query: 782  ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841
            E LK + E  K ++  L  Q +   A  R     + +L+T    L     E+K+++S   
Sbjct: 582  EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641

Query: 842  EKLEHEISHLKKKLENEVEQRHTLTRNLDVQ---LLDTKRQLDTETNLHLNTKELLKNAQ 898
             +++ +   L      +  QR  L  +LD     L D +++L+  T         L++ Q
Sbjct: 642  IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701

Query: 899  KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958
            +  + L+ HL   + +  S             ++  ++L  Q+++ E    ++K   + +
Sbjct: 702  EHCSQLESHLKEYKEKYLSL------------EQKTEELEGQIKKLEADSLEVKASKEQA 749

Query: 959  TSNVEQYQAMVTSLE---ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK 1015
              +++Q + + T LE     L+K+ ++ +E+  +  + L++ +E    +++KL + E+EK
Sbjct: 750  LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809

Query: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIA 1075
            Q L+ D     +  + Q  EL   + +   E+Q+                          
Sbjct: 810  QILKQDFETLSQETKIQHEELNNRIQTTVTELQKV------------------------- 844

Query: 1076 VEAQNKYERELMLHAADVEALQAAKEQVSKMA----SVRQHLEETTQKAESQLLECKASW 1131
                 K E+E ++       L   K+++SK++    + +   E+  QK ++ +L+ + + 
Sbjct: 845  -----KMEKEALM-----TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894

Query: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGK 1191
            +E +  L+ ++   +   ++L+K      +   +L  ++ +  ++ +Q     +L +  K
Sbjct: 895  KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA--QNTLKQNEK 952

Query: 1192 SQEQILEILRFIRREKEIAETRFEVAQVE-SLRYRQRVEL---LERELQELQDSLNAERE 1247
             ++Q+   +  +++  E  + + E  Q E  +   Q+ EL   L+++L +    L AE+E
Sbjct: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
            K+ V      + +E  K+ ++     E+      E     QDL+ ++ K+   + D++  
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRES------ELLATRQDLKSVEEKLSLAQEDLISN 1066

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEV--HT 1365
            +      ++    L+  K  LE+D  +   + Q L  + K     +  K L EKE+    
Sbjct: 1067 RNQIGNQNKLIQELKTAKATLEQDSAK---KEQQLQERCKALQDIQKEKSLKEKELVNEK 1123

Query: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK--DLDAKIID 1423
             ++ ++ E   R + EI + N  L +++  ++S+KE  N    ++  IQ+  +L  K   
Sbjct: 1124 SKLAEIEEIKCRQEKEITKLNEELKSHK--LESIKEITNLKDAKQLLIQQKLELQGKADS 1181

Query: 1424 IQEKVKTITQVKKIGR-RYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
            ++  V+   + ++I + + K + EELK +    +E  A+   + +E+ V +++ +E +  
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKE---FIEKEAKLHSEIKEKEVGMKKHEENEAK 1238

Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
            L    T   +L   +  ++K     +     L++QT  L+ E++ L   +Q+   +   L
Sbjct: 1239 LTMQIT---ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295

Query: 1543 RQQITEKE---EKTRKAIVAAKSKIAHLAGVKDQLTKENEELK 1582
             ++  + E   EK +  ++  + K+ +      +L +EN+ L+
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338



 Score =  163 bits (413), Expect = 2e-39
 Identities = 223/1060 (21%), Positives = 482/1060 (45%), Gaps = 122/1060 (11%)

Query: 664  EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-------------LEKLQEQVTDLRSQ 710
            E  + +A+LK+ +   E  KKE  + + +Q ++             L+ L++Q+ + +++
Sbjct: 91   EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE 150

Query: 711  NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770
            N  I    D   ++   L   +     +I S ++  + L    +  EQ +  +T++L   
Sbjct: 151  NFNIKQMKDLFEQKAAQLATEIA----DIKSKYDEERSLR---EAAEQKVTRLTEELN-- 201

Query: 771  NEKLAVAEVRAENLKK----EKEMLKLSEVRLSQQRESLLAE-QRGQNLLLTNLQTIQGI 825
             E   + +++ E L++    +  +LK   V++    +++  E +R    L    + +Q  
Sbjct: 202  KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261

Query: 826  LERSETETKQRLSSQIEKLEHEISHLKKKLE------NEVEQRH-TLTRNL-----DVQL 873
               SE    Q L S++ K   E++   ++L+      NE+ Q++ TLT NL     D   
Sbjct: 262  YASSEATISQ-LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320

Query: 874  LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
            L+ K   + E+    N +  L     +   L+  LS  E  +     + + KG+ + K  
Sbjct: 321  LEEKH--NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK-- 376

Query: 934  VDDLVSQLRQTEEQVNDLK---ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNI 990
               L  +L + E +   LK   ++L+      EQ+   + S    L+ +   TE      
Sbjct: 377  ---LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433

Query: 991  EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLS---ELKKTLSSV--QN 1045
              RLKE  +  ++   KLM+ E++  +LQ    R  E ++++++   EL+  L     Q+
Sbjct: 434  HGRLKEQRQLSSE---KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490

Query: 1046 EVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL-QAAKEQVS 1104
            + Q+ALQ+++TA   E  A+ D ++  +   +   K +        ++EAL Q +KE +S
Sbjct: 491  QEQQALQQSTTAKLRE--AQNDLEQVLRQIGDKDQKIQ--------NLEALLQKSKENIS 540

Query: 1105 KMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRL----LH 1160
             +   R+ L    Q  E +        +E+   L+++V++   + ++  + ++     LH
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH 599

Query: 1161 DQIEKLSDKVVASVKE--GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQ 1218
            DQ+++    + A+      ++  +N   S+  +S+E++ ++   I+ + E+  +      
Sbjct: 600  DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659

Query: 1219 VESLRYRQRVELLERELQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMNVVMETNK 1277
             +    +  ++  +  LQ+ Q  LN    ++ QVTAK       L  K E  + +    K
Sbjct: 660  AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK-------LQDKQEHCSQLESHLK 712

Query: 1278 MLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSE---KSGMLQAEKKLLEEDVKR 1334
              +E+   LEQ  ++++ +++KLE D L ++ +  +  +   +   L  + +L   ++ +
Sbjct: 713  EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772

Query: 1335 WKARNQHLVS------QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNAS 1388
                 + +VS      Q+K    E  ++ L+++E   +  Q L ++   L  E    +  
Sbjct: 773  QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE---EEKQILKQDFETLSQETKIQHEE 829

Query: 1389 LTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQ-VKKIGRRYKTQYEE 1447
            L N    IQ+   +L KV+ EKE +  +L      +++K+  ++  +K     ++ + ++
Sbjct: 830  LNNR---IQTTVTELQKVKMEKEALMTELST----VKDKLSKVSDSLKNSKSEFEKENQK 882

Query: 1448 LKAQQDKVMETSAQSSGDHQEQ-HVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506
             KA    + +T  +     Q Q   +++E +ELK++L + +  S  L+ ++ ++Q+ L +
Sbjct: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942

Query: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAH 1566
             +   +  +++  QLQ  ++ L+Q  + +  Q E L+ ++        K  V  K+++ +
Sbjct: 943  AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL--------KIAVLQKTELEN 994

Query: 1567 LAGVKDQLTKENEEL---KQRNGALDQQKDELDVRITALKSQYEGRISRL---ERELREH 1620
               ++ QLT+  +EL   K++   L    ++       L+S + GR S L    ++L+  
Sbjct: 995  --KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052

Query: 1621 QERHLEQRDEPQEPSNKVPEQQRQI-TLKTTPASGERGIA 1659
            +E+    +++     N++  Q + I  LKT  A+ E+  A
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092



 Score =  159 bits (403), Expect = 2e-38
 Identities = 245/1229 (19%), Positives = 517/1229 (42%), Gaps = 191/1229 (15%)

Query: 14   LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETR 73
            L K    VQ  ++    +++ E + LK   +K     + QY   E  +S  +  L    +
Sbjct: 226  LKKELVQVQTLMDNMTLERERESEKLKDECKKL----QSQYASSEATISQLRSELAKGPQ 281

Query: 74   ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNER 133
            E      EL+KL + +  LT+KN+ L    +  +  +  +T+ +E+   E      + + 
Sbjct: 282  EVAVYVQELQKLKSSVNELTQKNQTLT---ENLLKKEQDYTKLEEKHNEESV----SKKN 334

Query: 134  LSQELEYLTEDVKRLNEKLKESNTT----------KGELQLKLDELQASDVSVKYRE--- 180
            +   L     D ++L  +L  S T+          KGE   KL E + S+V  KY+    
Sbjct: 335  IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE-ELSEVETKYQHLKA 393

Query: 181  --KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN-------LENKKE 231
              K+L+Q++E        L +E+     +LL   R+ G     LK         L +K++
Sbjct: 394  EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453

Query: 232  EV-------SRLEEQMNGLKTSNEHLQKHV--------------EDLLTKLKEAK----- 265
            +V       SRLEEQ+    T++  LQ  +              +    KL+EA+     
Sbjct: 454  QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513

Query: 266  ----------------------EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
                                  ++  S+ EK   +L A I+      +  +  + K++ L
Sbjct: 514  VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573

Query: 304  TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
               V +L + LK   E++K  Q++L +  Q +    +   +++  LE  +   N  L+ +
Sbjct: 574  QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633

Query: 364  KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL 423
            K K   +S+ ++   + T   ++       +  +L N     Q+ L  ++ E  +I   L
Sbjct: 634  KEK---VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690

Query: 424  DEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDT--DKANKQSSV 481
            D++  +++ K     +     +  ++   SL  K E+   +I++L+ D+   KA+K+ ++
Sbjct: 691  DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750

Query: 482  LERDNRR-----MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH 536
             +   +R     +E++  +LS+Q     +E+E+     ++    +     S + E I Q 
Sbjct: 751  QDLQQQRQLNTDLELRATELSKQ-----LEMEK----EIVSSTRLDLQKKSEALESIKQK 801

Query: 537  LVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKS 596
            L      +++ +Q+   L    ++         +TT +++ +++++ E+ +TEL  ++  
Sbjct: 802  LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK-- 859

Query: 597  RQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAP 656
                    D + +  D  +   S+         A+ LD   L  T K             
Sbjct: 860  --------DKLSKVSDSLKNSKSEFEKENQKGKAAILD---LEKTCKE------------ 896

Query: 657  VPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKIST 716
               ++    ++ +  LK+ +E+ ++ +KEK  + +++ E L  +QEQ+  +++QNT    
Sbjct: 897  ---LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE-LNSMQEQL--IQAQNT---- 946

Query: 717  QLDFASKRYEMLQDNV-------EGYRREITSLHERNQ----KLTATTQKQEQIINTMTQ 765
             L    K  + LQ N+       E  +++I +L    +    + T    K +Q +    Q
Sbjct: 947  -LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQ 1005

Query: 766  DLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQG- 824
            +L    EK++V +    N +K +E  K  +     +   LLA ++    +   L   Q  
Sbjct: 1006 ELAAEKEKISVLQ---NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062

Query: 825  -ILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE 883
             I  R++   + +L  +++  +  +     K E ++++R    +++  +    +++L  E
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122

Query: 884  TNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQ 943
             +     +E+    +KEI  L + L + +++   +          +N +D   L+ Q   
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI---------TNLKDAKQLLIQ--- 1170

Query: 944  TEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ 1003
               Q  +L+ +  +  + VEQ +     L++ + KE+   EE++K     +++ A+  ++
Sbjct: 1171 ---QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE---EELKKEF---IEKEAKLHSE 1221

Query: 1004 LEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
            +++K  EV  +K E  + K      +  Q++ L + L +V+ E Q + +R S     E+Q
Sbjct: 1222 IKEK--EVGMKKHEENEAK------LTMQITALNENLGTVKKEWQSSQRRVSEL---EKQ 1270

Query: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKA--- 1120
                  E A +    QN  +    L    ++     ++  +K+  +++ L+ TT      
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330

Query: 1121 --ESQLLECKASWEERERMLKD-EVSKCV 1146
              E+Q L+ K +     +  +D EV  C+
Sbjct: 1331 GRENQSLQIKHTQALNRKWAEDNEVQNCM 1359



 Score = 94.7 bits (234), Expect = 9e-19
 Identities = 113/532 (21%), Positives = 230/532 (43%), Gaps = 42/532 (7%)

Query: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
            R +L K  +++++  +K L  Q+ E   LK   E    E++ Q+ E+  R+  +   L  
Sbjct: 785  RLDLQKKSEALESIKQK-LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843

Query: 71   ETRECQSLRLELEKLNNQLKALTE--KNKELEIAQDRNIA-----------------IQS 111
               E ++L  EL  + ++L  +++  KN + E  ++                     +Q 
Sbjct: 844  VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903

Query: 112  QFTRTKEELEAEKRDLIRTNE---RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE 168
            Q   T +E +  K+ L +  E   +L  EL  + E + +    LK++   + +LQ  ++E
Sbjct: 904  QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963

Query: 169  LQASDVSVKYREKRLEQEKELLHSQNTWLNTELK---TKTDELLALGREKGNEILELKCN 225
            L+ S    K + + L+ E ++   Q T L  +L+   T+  + LA  +EK   I  L+ N
Sbjct: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK---ISVLQNN 1020

Query: 226  LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKL 285
             E  +E   +L+    G ++     ++ ++ +  KL  A+E   S   +  N+     +L
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080

Query: 286  SNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI---QDHLLEVEQSKDQMEKEM 342
                 +   DS  K  +L    + L  + KE     K +   +  L E+E+ K + EKE+
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140

Query: 343  LEKIGRLEK-ELENANDLLSATKRKGAILSEE-ELAAMSPTAAAVAKIVKPGMKLTELYN 400
             +    L+  +LE+  ++ +    K  ++ ++ EL   + +  A  +  K   ++  L +
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI--LKD 1198

Query: 401  AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ 460
               + +++L  E +E +       ++  E++ K   +K+  E   +    + +L+  L  
Sbjct: 1199 QVKKEEEELKKEFIEKEA------KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252

Query: 461  AMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
              KE Q  Q    +  KQ+  L  +   +E  V++   + R LL    +  G
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG 1304



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 177/948 (18%), Positives = 369/948 (38%), Gaps = 143/948 (15%)

Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKS-- 1192
            E  +  +  K +   ++L K    +HD          A    G  G  N++L  +  +  
Sbjct: 39   EGFICPQCMKSLGSADELFKHYEAVHD----------AGNDSGHGGESNLALKRDDVTLL 88

Query: 1193 QEQILEILRFIRREKEIAET-RFEVAQVESLRYRQRVE--LLERELQELQDSLNAEREKV 1249
            ++++ ++   ++ EK  +E  + E+ + + L+ ++     L+     ELQ SL  + E+ 
Sbjct: 89   RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ-SLEQQLEEA 147

Query: 1250 QVTAKTMAQHEELM--KKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
            Q     + Q ++L   K  +    + +      EE+   E   Q++     +L  +   +
Sbjct: 148  QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDV---KRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH 1364
            Q+   EL ++ G+         EDV   K+   + Q L+         E  KL  E +  
Sbjct: 208  QDLKTELLQRPGI---------EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258

Query: 1365 TKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI 1424
              +       I +L++E+A+    +      +Q LK  +N++  + +T+ ++L  K  D 
Sbjct: 259  QSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318

Query: 1425 Q--EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGD--HQEQHVSVQEMQELK 1480
               E+      V K   +     ++L  QQ +   +++++S    H E     +  Q+LK
Sbjct: 319  TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378

Query: 1481 ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ------------------------- 1515
            E L++ ETK + L+++ + LQ+   EKE     LQ                         
Sbjct: 379  EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK 438

Query: 1516 --------------EQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAK 1561
                          +Q   LQ +LSRL + L+++ T   +L+ Q+ + +++ ++     +
Sbjct: 439  EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ 498

Query: 1562 SKIAHL-------------AGVKDQLTKENEELKQRN----GALDQQKDELDVRI----- 1599
            S  A L              G KDQ  +  E L Q++      L++++++L  +I     
Sbjct: 499  STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558

Query: 1600 -TALKSQYEGR-------ISRLERELREHQERHLEQR----DEPQEPSNKVPEQQRQITL 1647
             TA+ +Q + +       +++L  +L+   E H + +    D+ QE    +   Q ++  
Sbjct: 559  ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618

Query: 1648 KTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPA--- 1704
              T  +      + S    + +       T   ++A A    K+  RA ++  +  A   
Sbjct: 619  LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA---KTAQRADLQNHLDTAQNA 675

Query: 1705 -----TVTNPTTTPTATVMPTTQVESQEAMQSEGPV-EHVPVFGSTSGSVRSTSPNVQPS 1758
                    N  TT    V    Q + +   Q E  + E+   + S           ++  
Sbjct: 676  LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735

Query: 1759 ISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNI---VEVVQSSPVERPSTSTAV 1815
             +  +     + QA   +Q  +Q +  +E    ELS  +    E+V S+ ++    S A+
Sbjct: 736  EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795

Query: 1816 FGTVSATPSSSLPKRTREEEED-------STIEASDQVSDDTVEMPLPKKLKSVTPVGTE 1868
                     S   K T++EEE         T+    ++  + +   +   +  +  V  E
Sbjct: 796  --------ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847

Query: 1869 EE-VMAEESTDGEVETQVYNQ-DSQDSIGEGVTQGDYTPMEDSEET----SQSLQIDLGP 1922
            +E +M E ST  +  ++V +   +  S  E   Q     + D E+T       LQ+ +  
Sbjct: 848  KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907

Query: 1923 LQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEE 1970
               +Q+    S + + +    + ++ +  +E   +     +  E++E+
Sbjct: 908  TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 84/354 (23%), Positives = 163/354 (46%), Gaps = 37/354 (10%)

Query: 8    VLERTEL-NKLPKSVQNKLEKFLADQQSEIDGLKGRHEK----FK-------------VE 49
            VL++TEL NKL + +    ++ LA ++ +I  L+  +EK    FK             + 
Sbjct: 986  VLQKTELENKLQQQLTQAAQE-LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044

Query: 50   SEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN-KELEIAQDRNIA 108
            + Q    +E++LS +QE L++   +  +    +++L      L + + K+ +  Q+R  A
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104

Query: 109  ---IQSQFTRTKEELEAEKRDLIRTNE---RLSQELEYLTEDVKRLN-EKLKESNTTKGE 161
               IQ + +  ++EL  EK  L    E   R  +E+  L E++K    E +KE    K  
Sbjct: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDA 1164

Query: 162  LQLKLD---ELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA-LGREKGN 217
             QL +    ELQ    S+K   ++ ++ +++L  Q      ELK +  E  A L  E   
Sbjct: 1165 KQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE 1224

Query: 218  EILELKCNLENKKE---EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
            + + +K + EN+ +   +++ L E +  +K   +  Q+ V +L  +  + + + A +E  
Sbjct: 1225 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1284

Query: 275  FHN---ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
              N   E  A ++     +   +  + K  EL R ++     ++E G  N+++Q
Sbjct: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 970

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 971  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1030

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 1031 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1086

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1087 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1144

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1261

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1262 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1554 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1605

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1726 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2138

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2194

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2195 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2250

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2251 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2368

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2369 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2418

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2419 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2476

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2477 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2589

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSE 2613



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1679

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1680 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1732

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1844

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1959

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 1960 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 2015 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2062

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2063 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2111 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2270

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2566 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1060 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1118 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1177 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1224

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1277

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1278 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1384

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1439

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1500 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1615

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1616 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1667

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1728 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1843

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1844 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2142 AEQEAARRAQAEQA 2155



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 862  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 922  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 977

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 978  EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1031

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1090

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1091 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1150

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1266

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1321

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1322 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1371

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1372 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1543

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2120

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2416

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2477 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2521 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2215 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2394 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2622



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
            +Q +++N    D+   N KL +  +    L       ++S++++S Q E + A+++   L
Sbjct: 113  RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 164

Query: 815  LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
            LL + + ++G    R +  T    S +  +L + I H  K L  ++ +  R T   NLD 
Sbjct: 165  LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 221

Query: 872  QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
                 +R L     L     ++ +  +K I T    L +   +V   Q   R  + Q   
Sbjct: 222  AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 281

Query: 931  KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
            +E  + ++  L+         +ER   +S   +E   +     +E     K+  +   K 
Sbjct: 282  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 341

Query: 990  IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
            I   L+   ++ + +       ++VEKE  +L      AI   E+QL          + E
Sbjct: 342  IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 389

Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
              E LQR  T L  E      C+EQ   A            L  +DV  L A K  V + 
Sbjct: 390  RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 434

Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
            A     +E    KA+S +           R+L ++V       +    Q   ++ ++ +L
Sbjct: 435  AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 477

Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
             +++VA     ++   N                   +R +  +A    +VAQV     ++
Sbjct: 478  HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 513

Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
            R EL +  L+ LQD L   E  + +V  A+       +  +  +   + ++ +  R + E
Sbjct: 514  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
            R   D  Q+    R    D    L LQ A    S K          S +  A K+L+   
Sbjct: 574  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
               EE+V   W  RN ++ +++     E Y  L+ E E+  K+I++L     RL  E   
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 688

Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
            +  ++ + Q  +Q+    + ++    E   K+  A      +  +   Q++K+    + +
Sbjct: 689  ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 748

Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
            Y   ++     +E   Q + D +EQ
Sbjct: 749  YSCDRSATVTRLEDLLQDAQDEKEQ 773



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4448 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4508 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4544


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 919  RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 974

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 975  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1034

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 1035 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1090

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1091 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1148

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1149 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1265

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1266 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1318 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1377

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1437

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1438 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1497

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1557

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1558 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1609

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1610 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1730 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2142

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2198

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2199 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2254

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2255 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2372

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2373 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2422

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2423 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2480

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2481 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2593

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2594 ENQRLREQLQLLEEQHRAALAHSE 2617



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1683

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1684 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1736

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1848

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1963

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 1964 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 2019 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2066

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2067 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2115 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2274

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2331

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2332 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2391

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2392 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2449

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2570 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1064 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1122 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1181 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1228

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1281

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1282 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1329

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1330 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1388

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1443

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1444 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1503

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1504 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1619

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1620 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1671

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1732 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1847

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1848 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2085

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2146 AEQEAARRAQAEQA 2159



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 866  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 925

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 926  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 981

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 982  EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1035

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1036 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1094

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1095 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1154

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1155 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1214

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1270

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1271 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1325

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1326 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1375

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1376 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1435

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1547

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1602

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1783 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2124

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2304

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2305 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2364

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2420

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2481 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2525 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2219 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2277

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2337

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2338 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2398 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2626



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 174/829 (20%), Positives = 320/829 (38%), Gaps = 119/829 (14%)

Query: 673  KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
            +QL  + E  + +K    K  N+ L K Q  ++DL      +    +  S    +  D++
Sbjct: 36   QQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLYED---LRDGHNLISLLEVLSGDSL 92

Query: 733  --EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEM 790
              E  R     L      L     +Q +++N    D+   N KL +  +    L      
Sbjct: 93   PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILH----- 147

Query: 791  LKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEIS 849
             ++S++++S Q E + A+++   LLL + + ++G    R +  T    S +  +L + I 
Sbjct: 148  FQISDIQVSGQSEDMTAKEK---LLLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAII 201

Query: 850  HLKKKLENEVEQ--RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907
            H  K L  ++ +  R T   NLD      +R L     L     ++ +  +K I T    
Sbjct: 202  HRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSS 261

Query: 908  LSNMEVQVAS-QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQY 965
            L +   +V   Q   R  + Q   +E  + ++  L+         +ER   +S   +E  
Sbjct: 262  LYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 321

Query: 966  QAMVTSLEESLNKEKQVTEEVRKNIEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDK 1022
             +     +E     K+  +   K I   L+   ++ + +       ++VEKE  +L    
Sbjct: 322  WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV-- 379

Query: 1023 RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY 1082
              AI   E+QL          + E  E LQR  T L  E      C+EQ   A       
Sbjct: 380  --AILEREKQLRS--------EFERLECLQRIVTKLQMEAGL---CEEQLNQADA----- 421

Query: 1083 ERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV 1142
                 L  +DV  L A K  V + A     +E    KA+S +           R+L ++V
Sbjct: 422  -----LLQSDVRLLAAGK--VPQRAG---EVERDLDKADSMI-----------RLLFNDV 460

Query: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRF 1202
                   +    Q   ++ ++ +L +++VA     ++   N                   
Sbjct: 461  QTLK---DGRHPQGEQMYRRVYRLHERLVA-----IRTEYN------------------- 493

Query: 1203 IRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN-AEREKVQVT-AKTMAQHE 1260
            +R +  +A    +VAQV     ++R EL +  L+ LQD L   E  + +V  A+      
Sbjct: 494  LRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLP 553

Query: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK 1317
             +  +  +   + ++ +  R + ER   D  Q+    R    D    L LQ A    S K
Sbjct: 554  SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 613

Query: 1318 ----------SGMLQAEKKLL------EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSE 1360
                      S +  A K+L+      EE+V   W  RN ++ +++     E Y  L+ E
Sbjct: 614  ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRE 668

Query: 1361 KEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK 1420
             E+  K+I++L     RL  E   +  ++ + Q  +Q+    + ++    E   K+  A 
Sbjct: 669  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 728

Query: 1421 IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ 1469
                 +  +   Q++K+    + +Y   ++     +E   Q + D +EQ
Sbjct: 729  FQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 777



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4452 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4511

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4512 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4548


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 970

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 971  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1030

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 1031 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1086

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1087 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1144

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1261

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1262 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1554 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1605

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1726 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2138

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2194

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2195 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2250

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2251 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2368

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2369 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2418

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2419 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2476

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2477 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2589

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSE 2613



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1679

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1680 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1732

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1844

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1959

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 1960 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 2015 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2062

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2063 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2111 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2270

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2566 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1060 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1118 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1177 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1224

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1277

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1278 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1384

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1439

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1500 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1615

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1616 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1667

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1728 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1843

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1844 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2142 AEQEAARRAQAEQA 2155



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 862  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 922  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 977

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 978  EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1031

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1090

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1091 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1150

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1266

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1321

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1322 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1371

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1372 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1543

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2120

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2416

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2477 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2521 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2215 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2394 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2622



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
            +Q +++N    D+   N KL +  +    L       ++S++++S Q E + A+++   L
Sbjct: 113  RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 164

Query: 815  LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
            LL + + ++G    R +  T    S +  +L + I H  K L  ++ +  R T   NLD 
Sbjct: 165  LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 221

Query: 872  QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
                 +R L     L     ++ +  +K I T    L +   +V   Q   R  + Q   
Sbjct: 222  AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 281

Query: 931  KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
            +E  + ++  L+         +ER   +S   +E   +     +E     K+  +   K 
Sbjct: 282  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 341

Query: 990  IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
            I   L+   ++ + +       ++VEKE  +L      AI   E+QL          + E
Sbjct: 342  IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 389

Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
              E LQR  T L  E      C+EQ   A            L  +DV  L A K  V + 
Sbjct: 390  RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 434

Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
            A     +E    KA+S +           R+L ++V       +    Q   ++ ++ +L
Sbjct: 435  AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 477

Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
             +++VA     ++   N                   +R +  +A    +VAQV     ++
Sbjct: 478  HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 513

Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
            R EL +  L+ LQD L   E  + +V  A+       +  +  +   + ++ +  R + E
Sbjct: 514  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
            R   D  Q+    R    D    L LQ A    S K          S +  A K+L+   
Sbjct: 574  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
               EE+V   W  RN ++ +++     E Y  L+ E E+  K+I++L     RL  E   
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 688

Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
            +  ++ + Q  +Q+    + ++    E   K+  A      +  +   Q++K+    + +
Sbjct: 689  ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 748

Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
            Y   ++     +E   Q + D +EQ
Sbjct: 749  YSCDRSATVTRLEDLLQDAQDEKEQ 773



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4448 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4508 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4544


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 883  RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 938

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 939  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 998

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 999  AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1054

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1055 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1112

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1113 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1229

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1230 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1341

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1401

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1402 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1461

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1521

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1522 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1573

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1574 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1634 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1694 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2106

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2162

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2163 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2218

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2219 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2336

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2337 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2386

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2387 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2444

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2445 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2557

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2558 ENQRLREQLQLLEEQHRAALAHSE 2581



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1647

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1648 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1700

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1812

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1927

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 1928 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 1983 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2030

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2031 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2079 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2238

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2295

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2296 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2355

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2356 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2413

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2534 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1028 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1086 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1144

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1145 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1192

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1245

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1246 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1293

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1294 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1352

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1407

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1408 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1467

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1468 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1583

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1584 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1635

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1696 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1811

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1812 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2049

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2110 AEQEAARRAQAEQA 2123



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 830  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 889

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 890  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 945

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 946  EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 999

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1000 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1058

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1059 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1118

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1119 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1178

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1234

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1235 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1289

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1290 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1339

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1340 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1399

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1511

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1566

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1747 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2088

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2268

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2269 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2328

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2384

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2445 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2489 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2183 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2241

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2301

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2302 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2362 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2590



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
            +Q +++N    D+   N KL +  +    L       ++S++++S Q E + A+++   L
Sbjct: 81   RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 132

Query: 815  LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
            LL + + ++G    R +  T    S +  +L + I H  K L  ++ +  R T   NLD 
Sbjct: 133  LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 189

Query: 872  QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
                 +R L     L     ++ +  +K I T    L +   +V   Q   R  + Q   
Sbjct: 190  AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 249

Query: 931  KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
            +E  + ++  L+         +ER   +S   +E   +     +E     K+  +   K 
Sbjct: 250  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 309

Query: 990  IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
            I   L+   ++ + +       ++VEKE  +L      AI   E+QL          + E
Sbjct: 310  IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 357

Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
              E LQR  T L  E      C+EQ   A            L  +DV  L A K  V + 
Sbjct: 358  RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 402

Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
            A     +E    KA+S +           R+L ++V       +    Q   ++ ++ +L
Sbjct: 403  AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 445

Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
             +++VA     ++   N                   +R +  +A    +VAQV     ++
Sbjct: 446  HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 481

Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
            R EL +  L+ LQD L   E  + +V  A+       +  +  +   + ++ +  R + E
Sbjct: 482  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 541

Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
            R   D  Q+    R    D    L LQ A    S K          S +  A K+L+   
Sbjct: 542  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 601

Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
               EE+V   W  RN ++ +++     E Y  L+ E E+  K+I++L     RL  E   
Sbjct: 602  EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 656

Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
            +  ++ + Q  +Q+    + ++    E   K+  A      +  +   Q++K+    + +
Sbjct: 657  ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 716

Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
            Y   ++     +E   Q + D +EQ
Sbjct: 717  YSCDRSATVTRLEDLLQDAQDEKEQ 741



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4416 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4475

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4476 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4512


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 1107

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 1108 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1167

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 1168 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1223

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1224 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1281

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1398

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1399 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1451 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1510

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1570

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1571 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1630

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1690

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1691 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1742

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1743 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1863 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2275

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2331

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2332 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2387

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2388 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2505

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2506 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2555

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2556 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2613

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2614 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2726

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2727 ENQRLREQLQLLEEQHRAALAHSE 2750



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1816

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1817 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1869

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1981

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 2096

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 2097 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 2152 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2199

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2200 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2248 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2407

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2464

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2465 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2524

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2525 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2582

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2703 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1197 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1255 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1313

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1314 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1361

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1414

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1415 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1462

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1463 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1521

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1576

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1637 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1752

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1753 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1804

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1865 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1980

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1981 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2279 AEQEAARRAQAEQA 2292



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 999  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1058

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 1059 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 1114

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 1115 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1168

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1169 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1227

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1228 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1287

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1347

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1403

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1404 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1458

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1459 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1508

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1509 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1568

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1680

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1735

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1916 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2257

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2437

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2438 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2497

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2553

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2614 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2658 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2352 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2410

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2470

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2471 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2531 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2759



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 182/872 (20%), Positives = 333/872 (38%), Gaps = 141/872 (16%)

Query: 633  LDDVSLASTPKRPSTSQTVST---PAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAEN 689
            L++VS   TP  P+T+Q       P P P  +  + ++ K   K +              
Sbjct: 145  LEEVS-PETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWV-------------- 189

Query: 690  EKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV--EGYRREITSLHERNQ 747
                N+ L K Q  ++DL      +    +  S    +  D++  E  R     L     
Sbjct: 190  ----NKHLIKAQRHISDLYED---LRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQI 242

Query: 748  KLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
             L     +Q +++N    D+   N KL +  +    L       ++S++++S Q E + A
Sbjct: 243  ALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTA 297

Query: 808  EQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHT 864
            +++   LLL + + ++G    R +  T    S +  +L + I H  K L  ++ +  R T
Sbjct: 298  KEK---LLLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351

Query: 865  LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRT 923
               NLD      +R L     L     ++ +  +K I T    L +   +V   Q   R 
Sbjct: 352  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA 411

Query: 924  GKGQPSNKEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQV 982
             + Q   +E  + ++  L+         +ER   +S   +E   +     +E     K+ 
Sbjct: 412  NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEA 471

Query: 983  TEEVRKNIEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKT 1039
             +   K I   L+   ++ + +       ++VEKE  +L      AI   E+QL      
Sbjct: 472  DKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS---- 523

Query: 1040 LSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAA 1099
                + E  E LQR  T L  E      C+EQ   A            L  +DV  L A 
Sbjct: 524  ----EFERLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAG 566

Query: 1100 KEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLL 1159
            K  V + A     +E    KA+S +           R+L ++V       +    Q   +
Sbjct: 567  K--VPQRAG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQM 607

Query: 1160 HDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQV 1219
            + ++ +L +++VA     ++   N                   +R +  +A    +VAQV
Sbjct: 608  YRRVYRLHERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQV 643

Query: 1220 ESLRYRQRVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNK 1277
                 ++R EL +  L+ LQD L   E  + +V  A+       +  +  +   + ++ +
Sbjct: 644  TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 703

Query: 1278 MLREEKERLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAE 1324
              R + ER   D  Q+    R    D    L LQ A    S K          S +  A 
Sbjct: 704  EFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAAT 763

Query: 1325 KKLL------EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR 1377
            K+L+      EE+V   W  RN ++ +++     E Y  L+ E E+  K+I++L     R
Sbjct: 764  KELMWLNEKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDR 818

Query: 1378 LKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKI 1437
            L  E   +  ++ + Q  +Q+    + ++    E   K+  A      +  +   Q++K+
Sbjct: 819  LLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKL 878

Query: 1438 GRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ 1469
                + +Y   ++     +E   Q + D +EQ
Sbjct: 879  QEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 910



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4585 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4645 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4681


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 893  RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 948

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 949  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1008

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 1009 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1064

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1065 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1122

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1239

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1240 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1292 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1351

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1411

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1412 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1471

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1531

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1532 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1583

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1584 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1704 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2116

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2172

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2173 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2228

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2229 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2346

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2347 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2396

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2397 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2454

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2455 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2567

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2568 ENQRLREQLQLLEEQHRAALAHSE 2591



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1657

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1658 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1710

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1822

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 1883 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1937

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 1938 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 1993 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2040

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2041 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2089 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2248

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2305

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2306 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2365

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2366 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2423

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2544 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1038 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1096 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1155 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1202

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1255

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1256 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1303

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1304 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1362

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1417

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1478 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1535

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1593

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1594 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1645

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1706 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1821

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1822 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2059

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2120 AEQEAARRAQAEQA 2133



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 840  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 899

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 900  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 955

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 956  EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1009

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1010 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1068

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1069 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1128

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1188

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1244

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1245 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1299

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1300 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1349

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1350 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1409

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1521

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1576

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1756

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2098

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2278

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2279 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2338

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2394

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2455 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2499 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2193 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2251

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2311

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2312 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2372 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2600



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
            +Q +++N    D+   N KL +  +    L       ++S++++S Q E + A+++   L
Sbjct: 91   RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 142

Query: 815  LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
            LL + + ++G    R +  T    S +  +L + I H  K L  ++ +  R T   NLD 
Sbjct: 143  LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 199

Query: 872  QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
                 +R L     L     ++ +  +K I T    L +   +V   Q   R  + Q   
Sbjct: 200  AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 259

Query: 931  KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
            +E  + ++  L+         +ER   +S   +E   +     +E     K+  +   K 
Sbjct: 260  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 319

Query: 990  IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
            I   L+   ++ + +       ++VEKE  +L      AI   E+QL          + E
Sbjct: 320  IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 367

Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
              E LQR  T L  E      C+EQ   A            L  +DV  L A K  V + 
Sbjct: 368  RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 412

Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
            A     +E    KA+S +           R+L ++V       +    Q   ++ ++ +L
Sbjct: 413  AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 455

Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
             +++VA     ++   N                   +R +  +A    +VAQV     ++
Sbjct: 456  HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 491

Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
            R EL +  L+ LQD L   E  + +V  A+       +  +  +   + ++ +  R + E
Sbjct: 492  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 551

Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
            R   D  Q+    R    D    L LQ A    S K          S +  A K+L+   
Sbjct: 552  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 611

Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
               EE+V   W  RN ++ +++     E Y  L+ E E+  K+I++L     RL  E   
Sbjct: 612  EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 666

Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
            +  ++ + Q  +Q+    + ++    E   K+  A      +  +   Q++K+    + +
Sbjct: 667  ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 726

Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
            Y   ++     +E   Q + D +EQ
Sbjct: 727  YSCDRSATVTRLEDLLQDAQDEKEQ 751



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4426 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4486 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4522


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 901  RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 956

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 957  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1016

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 1017 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1072

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1073 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1130

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1247

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1248 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1300 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1359

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1419

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1420 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1479

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1539

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1540 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1591

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1592 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1651

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1652 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1712 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2124

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2180

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2181 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2236

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2237 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2354

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2355 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2404

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2405 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2462

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2463 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2575

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2576 ENQRLREQLQLLEEQHRAALAHSE 2599



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1665

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1666 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1718

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1830

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1945

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 1946 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 2001 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2048

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2049 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2097 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2142

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2256

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2313

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2314 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2373

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2374 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2431

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2552 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1046 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1104 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1163 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1210

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1263

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1264 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1311

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1312 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1370

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1425

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1426 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1485

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1486 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1543

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1601

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1602 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1653

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1714 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1829

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1830 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2067

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2128 AEQEAARRAQAEQA 2141



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 848  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 907

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 908  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 963

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 964  EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1017

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1018 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1076

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1077 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1136

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1137 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1196

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1197 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1252

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1253 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1307

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1308 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1357

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1358 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1417

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1529

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1584

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1764

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1765 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2106

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2226

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2227 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2286

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2287 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2346

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2402

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2463 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2507 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2201 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2259

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2319

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2320 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2380 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2608



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 175/835 (20%), Positives = 323/835 (38%), Gaps = 124/835 (14%)

Query: 672  LKQLQEIFENYKKEKAENEKIQ-----NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE 726
            ++  +E+ E YK E+   +K       N+ L K Q  ++DL      +    +  S    
Sbjct: 12   IQAYEEVREKYKDERDRVQKKTFTKWVNKHLIKAQRHISDLYED---LRDGHNLISLLEV 68

Query: 727  MLQDNV--EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            +  D++  E  R     L      L     +Q +++N    D+   N KL +  +    L
Sbjct: 69   LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 128

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEK 843
                   ++S++++S Q E + A+++   LLL + + ++G    R +  T    S +  +
Sbjct: 129  H-----FQISDIQVSGQSEDMTAKEK---LLLWSQRMVEGYQGLRCDNFTS---SWRDGR 177

Query: 844  LEHEISHLKKKLENEVEQ--RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEI 901
            L + I H  K L  ++ +  R T   NLD      +R L     L     ++ +  +K I
Sbjct: 178  LFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSI 237

Query: 902  ATLKQHLSNMEVQVAS-QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER-LKTST 959
             T    L +   +V   Q   R  + Q   +E  + ++  L+         +ER   +S 
Sbjct: 238  ITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSF 297

Query: 960  SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK---ESAEFQTQLEKKLMEVEKEKQ 1016
              +E   +     +E     K+  +   K I   L+   ++ + +       ++VEKE  
Sbjct: 298  EEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWG 357

Query: 1017 ELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV 1076
            +L      AI   E+QL          + E  E LQR  T L  E      C+EQ   A 
Sbjct: 358  KLHV----AILEREKQLRS--------EFERLECLQRIVTKLQMEAGL---CEEQLNQAD 402

Query: 1077 EAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
                       L  +DV  L A K  V + A     +E    KA+S +           R
Sbjct: 403  A----------LLQSDVRLLAAGK--VPQRAG---EVERDLDKADSMI-----------R 436

Query: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI 1196
            +L ++V       +    Q   ++ ++ +L +++VA     ++   N             
Sbjct: 437  LLFNDVQTLK---DGRHPQGEQMYRRVYRLHERLVA-----IRTEYN------------- 475

Query: 1197 LEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN-AEREKVQVT-AK 1254
                  +R +  +A    +VAQV     ++R EL +  L+ LQD L   E  + +V  A+
Sbjct: 476  ------LRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAE 529

Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI---LPLQEAN 1311
                   +  +  +   + ++ +  R + ER   D  Q+    R    D    L LQ A 
Sbjct: 530  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 589

Query: 1312 AELSEK----------SGMLQAEKKLL------EEDVK-RWKARNQHLVSQQKDPDTEEY 1354
               S K          S +  A K+L+      EE+V   W  RN ++ +++     E Y
Sbjct: 590  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKK-----ESY 644

Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
              L+ E E+  K+I++L     RL  E   +  ++ + Q  +Q+    + ++    E   
Sbjct: 645  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 704

Query: 1415 KDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ 1469
            K+  A      +  +   Q++K+    + +Y   ++     +E   Q + D +EQ
Sbjct: 705  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 759



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4434 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4493

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4494 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4530


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  206 bits (524), Expect = 2e-52
 Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
            + L+  E  +   S++   + FL D Q       G   + ++ +E++Y       ++L  
Sbjct: 942  RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 997

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
            S E+   E   CQ    EL+ +  QL+A  T     L +  D+  A + +Q    +++ +
Sbjct: 998  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1057

Query: 122  AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
            AE   L +   RLS E     E V  L E    + T + EL+L L +L Q   +S  Y E
Sbjct: 1058 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1113

Query: 181  KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
            K           +  +E+L +    L  E +     L  L   K + + +L+   E ++ 
Sbjct: 1114 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1171

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
                L +++ G +   E LQ+   +   +++  +E+ A + E++            EL  
Sbjct: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231

Query: 282  HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
              +    Y+ +AD   A   +  R  E++  +     +A   +++ L + +   +++E+ 
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1288

Query: 341  -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
             E +E+  R  K+  NA         K   L      A     A+ AK  K       + 
Sbjct: 1289 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340

Query: 400  NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
              YV+ +           +  K++ E ++ +E +  + ++QR EE ER  +  A+L  + 
Sbjct: 1341 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1400

Query: 459  EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
            + A    Q   +   +A +    ++ +  R E    D  QQ R +  EL++ R +     
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1460

Query: 519  E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
            + +   A+ +  S +  +  +    ++    + QR         L A  E  E ++R+ Q
Sbjct: 1461 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1520

Query: 570  ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
            E            S +  + +++L S +    +  + +Q  +Q ++ +  Q +     L 
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1580

Query: 620  QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
            Q       +  +    V+L  T +R + ++  S  A     E T  +E        A+ Q
Sbjct: 1581 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1632

Query: 675  LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
            L+E  E   +++AE E+ + E   +LE+ Q +  +   LR Q  +++ Q   A    E  
Sbjct: 1633 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692

Query: 729  QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            ++  E   R      E   R ++L     +KQ Q+     Q    A ++L       E  
Sbjct: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
            ++++++L+    RL  QRE+  A Q+ Q L      +   ++ +     R+E E+     
Sbjct: 1753 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810

Query: 834  --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
              KQRL ++     +L  E + L+   E    QR     +   Q  + +R          
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870

Query: 879  ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
               +L TE  + L  KE     L+   ++ A  ++ L     Q  +   +R  + + ++ 
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930

Query: 932  ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
             +       V+D + Q RQ EE++  LK   + + +   + +  +    ++ E++L  ++
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990

Query: 981  QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
            Q   E              R+  E R+++S  AE +   ++K  L EVE+ K ++++ +R
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050

Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
               RA +   +QL            +E K    +VQ    E+Q+ LQ+  + L   +   
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110

Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
               +  A+ A EA+ + ERE       VE  +  K+   + A  R   +   +K     L
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2165

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              +A  E   R   ++ +    +  D E +    H +  + + +  A V++ +   L + 
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2221

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
            L E    +  + E L+  R + E  E   + +QVE   +  RV++   EL +L+  + AE
Sbjct: 2222 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2277

Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
               + +  K   Q   L ++ E M  V E    L    +E  RL    E+DL Q +A   
Sbjct: 2278 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K+  + +   +    L  ++ +LQ +K+L +E  +R +  ++  ++QQ   +T+ +++ L
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2395

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
               E   +R  +++ E  RLK  +A  + +           +ED  + R + E I + L 
Sbjct: 2396 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2445

Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
               +  QEKV T+ Q  +I R        R +    EL+ +++K ++  A+      E+ 
Sbjct: 2446 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2503

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
             +VQ+ Q L+ET    +   +S  S+ ++L +     E E   L++      ++  +LR+
Sbjct: 2504 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            + Q +  Q EQ RQ++    E+ R+    A+  +      +++L +  ++ +Q+   L +
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2616

Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
            +   L  ++  L+ Q+   ++  E
Sbjct: 2617 ENQRLREQLQLLEEQHRAALAHSE 2640



 Score =  132 bits (333), Expect = 3e-30
 Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)

Query: 19   KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
            + VQ  LE      ++E+   +    +   + E+   E      +L    ER   +  E 
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647

Query: 76   QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
            +  R E E+     QLKA   L  + +  E+AQ +++A Q++  + KEE E E R   + 
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1706

Query: 131  NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             E+  ++ E   ++++      K+    +G  Q +L   Q   + ++   ++ EQ+++LL
Sbjct: 1707 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1759

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
              +   L  E    T +   L  E      E++  L +K   EE SR   + +  +   E
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819

Query: 249  -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
                  L +    L    +EAK Q Q + E+       A   L+        +  A   E
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1871

Query: 303  LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
             TR   E    LKE    N+ +    +D   +   +E+   Q + ++ E++ +L K    
Sbjct: 1872 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            ELE    L+  T R+   + EE LA  +    A A     G    EL    + +  +  L
Sbjct: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1986

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
               E   +     E  ++ +  A   +R+RE  ER QK++A+      Q   A++E++RL
Sbjct: 1987 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +   ++A +     E+++ R       L+Q+     ++ EE      ++ +E        
Sbjct: 2042 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2089

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
                        + +++  QQ Q +L  LR   E   R  +E   +++   +   +S   
Sbjct: 2090 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137

Query: 587  LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
            + E E+L++S + Q Q                +Q    A  L   +  + +  +  ++ +
Sbjct: 2138 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2183

Query: 647  TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
              Q  +  A +   +  + + +  KA ++Q         +E    + + +E+L++L+ + 
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243

Query: 705  TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
            T+   Q +++  +L     + E L         E  +L  R++  T    ++E       
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2297

Query: 765  QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
            + ++   E+ A   V A+   + ++   L+E  L+QQR   E +L E+       T L+ 
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2354

Query: 822  IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
               +L++ +    E  +RL    E++  +++   +  +  +E        +  +    K 
Sbjct: 2355 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2414

Query: 879  QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            ++   +      +E  +  +K+   + + L   E+  A+Q      +     ++  D   
Sbjct: 2415 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2472

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
             +LR+   ++   KE+L+     ++ + + M T  +E L +E Q  ++   + +  L + 
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532

Query: 998  AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
              F  Q + KL ++ +++    Q+L+++++R  + MEQ+   L  ++      Q+E +E 
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
            ++R    L   +Q RR   +Q ++  E   +   +L L      A  A  E+V+
Sbjct: 2593 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643



 Score =  114 bits (284), Expect = 1e-24
 Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)

Query: 781  AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
            A  L+ E E+   KL +VR        L + +  +L++   Q  + +L   E + K  Q 
Sbjct: 1087 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144

Query: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
            + + + +LE   + LKK L  + E +      L  +L   +   +     H      ++ 
Sbjct: 1145 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1203

Query: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
             ++ +A L +        V +Q+  R        + +++ L  QLR   E  + L   L+
Sbjct: 1204 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1251

Query: 957  TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
             +    EQ QAM  +    + E L +E+ + EE+ ++ E +++E   F  Q         
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1304

Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
                        AI+  E QL   K  L  V +  ++  +Q  S ++  E    R    +
Sbjct: 1305 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1352

Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
                     K+  E +    + E L  Q   E+  ++A V   LE+  Q AE+   + KA
Sbjct: 1353 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1411

Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
              E   + L+  + + V R E    D ++Q R + +++++L     A ++   +      
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1466

Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
                 +S+ +I E +R +R + E  E               R E A+ +  + ++  E L
Sbjct: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
             R++Q+  +S    + +V++ ++  A+ E   +K   +  + E      E + RL Q   
Sbjct: 1527 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1584

Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
               +Q+Q  +   +      LQ   A  +EK+  L  E+ L EE V   + R +     Q
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1642

Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
            +  + E  R+   E E   +R Q    E  RL+ +     A     Q  +   + +  K 
Sbjct: 1643 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1694

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              E+E  ++    +    Q ++      K+      T  + L A+Q+ +   +    G+ 
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754

Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
            Q Q +  +E+  L+     A  K + LE+++       E L  + +  E E+R+  E++ 
Sbjct: 1755 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813

Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
            Q L++E  R R+  ++    R   EE  RQ+   +E+  R+   A +     LA +    
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1870

Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
              E   LK       ++K+  + R+  L      +  RLE +  +H+    E+  + ++ 
Sbjct: 1871 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928

Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
            S+   E+Q+ +   TL+      E  +A  +    A      +     ++ + A    +S
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988

Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
              +A +   R     A            V  +   E + A Q +  +E V    +     
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048

Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
            R      +   ++ +   Q+      Q +  A     QQ   +++   Q+  S + ++  
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2108

Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
             +   R +   A    V A   ++  +R  EE E     A +Q           +KL+  
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168

Query: 1863 TPVGTEEEVMAEES 1876
                      AE++
Sbjct: 2169 AEQEAARRAQAEQA 2182



 Score =  110 bits (276), Expect = 1e-23
 Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)

Query: 743  HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
            ++  Q+     + Q Q + T+   L       LA   +R +  L +   +     ++  +
Sbjct: 889  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 948

Query: 801  QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
            QR++L + +      L + Q   G         ++   S      H    L + LE   +
Sbjct: 949  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 1004

Query: 861  QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +     R +  +L D + QL+  ET  +H     L K   +E A   Q ++  E Q A  
Sbjct: 1005 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1058

Query: 919  SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
              +  GKG      + + +++ L +       L+  L+ +   +EQ +++     E L  
Sbjct: 1059 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1117

Query: 978  -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
                 +  Q  EEV +  E +LKE+      L +        K +  + E Q+     L+
Sbjct: 1118 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1177

Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
            D+ R A E    ++Q+  E    +   +  V + L+R    L+     +R+ ++  +   
Sbjct: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1237

Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
                    +    Q+   R+  + A  +   QA +EQ+ +  ++ + +E   +K E    
Sbjct: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1293

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
            EC+   ++    +KD   + V     LE   +     +++  S+ V+    +     L  
Sbjct: 1294 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1348

Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
              SE      Q +         K I+ET   + + E L  +QR E  ER L E++ +L  
Sbjct: 1349 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1398

Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
            +R+  +  A+  AQ             EE++++ E      +  + ++EE ++L Q  + 
Sbjct: 1399 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1458

Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
            ++QAK R+ E           E+      L+A ++     E +++  +AR +   +Q++ 
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
               E  R     ++   ++ Q   E   R+KAE   +       Q  +Q+L+E    +R 
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1570

Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
            + E  ++ L    ++   +V+   +  +     ++   EL++++    E +AQ     QE
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1625

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
            +HV+V +++E  E   Q + +++    + E   +    K  EA  L+ Q  ++  + S  
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685

Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
                           R R   +++  ++ +L +Q  EK+    E T +  +AA+ ++  L
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745

Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
                +Q       L +E   L++   A  Q++ EL+  +  ++++ E  +   +R E E 
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1805

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            R   E+  ++ +       ++ E+  ++      A  +R +A
Sbjct: 1806 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)

Query: 22   QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
            + +L++ L  +QS +D L+G  E  +    E+E+   + E+  + S+ R V E    +  
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2147

Query: 79   RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
              E  +   Q +A  EK  KE E    R    +    R K+  +AE     +  E+  ++
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207

Query: 138  LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
               + +++  L  +L+E++  K  L  +L  L+A       +  ++E+E           
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2267

Query: 187  ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
               K  + ++N  L    K  T   L    EK  ++ E    L    +E +RL +     
Sbjct: 2268 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2327

Query: 239  --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
                                +   LK   E LQ+  E   +   +L+E KEQ A      
Sbjct: 2328 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2387

Query: 270  ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
                  ++E +   +L    +   L    A+ S A++    RA E+  +  K+A E  + 
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2443

Query: 323  ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
                  A Q+ +     LE+++ +   + E L E I  LE+E E       LL     + 
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
              + +E+L  +  T A              L  +++  +D LL  +   ++    L+++ 
Sbjct: 2504 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547

Query: 428  KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
            ++  AKA  L   REE +R Q+ +     +L  +M+E +R Q + ++    KQ  +  LE
Sbjct: 2548 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604

Query: 484  RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
            +  R+ E  + + +Q++R  L  LEE     +   EEV+++ ++++
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
            E TE  +    V+ +L      Q  E+  LK R E           ++ Q++ + E    
Sbjct: 2242 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2300

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
            K+++    RL    +E   LR   E+   Q +AL EK    K   + +   +  +++  +
Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2360

Query: 116  TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
             ++EL  E+ R L    E+++Q+L   T+  +R  E  +    E +     L+L++ E+ 
Sbjct: 2361 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420

Query: 170  ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
                +A + + ++R K+ E+  E LH   T L T+ K    + L + R++ +   E L+ 
Sbjct: 2421 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477

Query: 225  NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
             +   + E  +L+++   L+  +E +Q                      + LL + +  +
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537

Query: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
            +++A +E+ F +E+    +L    +      E +   L  ++EE  +   EA E  +  Q
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 326  DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
            + L ++EQ + Q E+ + E+  RL ++L+     L   + + A+   EE+ A    A
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2649



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
            +Q +++N    D+   N KL +  +    L       ++S++++S Q E + A+++   L
Sbjct: 140  RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 191

Query: 815  LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
            LL + + ++G    R +  T    S +  +L + I H  K L  ++ +  R T   NLD 
Sbjct: 192  LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 248

Query: 872  QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
                 +R L     L     ++ +  +K I T    L +   +V   Q   R  + Q   
Sbjct: 249  AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 308

Query: 931  KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
            +E  + ++  L+         +ER   +S   +E   +     +E     K+  +   K 
Sbjct: 309  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 368

Query: 990  IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
            I   L+   ++ + +       ++VEKE  +L      AI   E+QL          + E
Sbjct: 369  IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 416

Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
              E LQR  T L  E      C+EQ   A            L  +DV  L A K  V + 
Sbjct: 417  RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 461

Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
            A     +E    KA+S +           R+L ++V       +    Q   ++ ++ +L
Sbjct: 462  AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 504

Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
             +++VA     ++   N                   +R +  +A    +VAQV     ++
Sbjct: 505  HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 540

Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
            R EL +  L+ LQD L   E  + +V  A+       +  +  +   + ++ +  R + E
Sbjct: 541  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600

Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
            R   D  Q+    R    D    L LQ A    S K          S +  A K+L+   
Sbjct: 601  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660

Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
               EE+V   W  RN ++ +++     E Y  L+ E E+  K+I++L     RL  E   
Sbjct: 661  EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 715

Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
            +  ++ + Q  +Q+    + ++    E   K+  A      +  +   Q++K+    + +
Sbjct: 716  ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 775

Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
            Y   ++     +E   Q + D +EQ
Sbjct: 776  YSCDRSATVTRLEDLLQDAQDEKEQ 800



 Score = 32.0 bits (71), Expect = 7.4
 Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)

Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
            D  D  M +EG        +A    GY +  +  G G+  G+ T    G   G+ R + D
Sbjct: 4475 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534

Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
            +  SG   T ++ S  S    R     S++    P +
Sbjct: 4535 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4571


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  202 bits (515), Expect = 2e-51
 Identities = 344/1655 (20%), Positives = 718/1655 (43%), Gaps = 261/1655 (15%)

Query: 47   KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTE--KNKELEIAQD 104
            KVES ++  ++E ++    ++L +   +   LR E E+LN + + + E  +N +LE ++ 
Sbjct: 301  KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL 360

Query: 105  RNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQL 164
            +  A++   T T++E    +   +    RL Q L     ++ RL+   ++++  +  L+L
Sbjct: 361  QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL 420

Query: 165  KLDELQASDVSVKYREKR-LEQEKELLHSQNTWLNTE---LKTKTDELLALGREKGNEIL 220
            K+       + V  +EK  L QEKE L      LN E   +K+     ++L     +E+ 
Sbjct: 421  KM------RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL----DSELH 470

Query: 221  ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
            +L+ NLE K       E+++N   +  E L   +E+L  + +EA +    ++++   + N
Sbjct: 471  DLRLNLEAK-------EQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQN 523

Query: 281  AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
                + +  K   +D + + ++L     ++ K L    E  K IQ    EV  +   + K
Sbjct: 524  EGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE--KLIQS---EVALNDLHLTK 578

Query: 341  EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
            +      +LE ++EN  D L+ ++     + +E L             +K  ++  E   
Sbjct: 579  Q------KLEDKVENLVDQLNKSQESNVSIQKENLE------------LKEHIRQNEEEL 620

Query: 401  AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAV--ASLSVKL 458
            + +  +   L++ L     + + D ++KE EA+   LK+   E E+  + +   +  VK+
Sbjct: 621  SRIRNE---LMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM 677

Query: 459  EQ-----AMKEIQRLQEDTDKANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELEEAR 511
            E      A ++++   E+    N Q S LE++     ++++  ++  ++      L E  
Sbjct: 678  ENEKLVLACEDVRHQLEECLAGNNQLS-LEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736

Query: 512  GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
              +    EE+S+A   ++S +  +H     ++ +L Q+    +  L++  E  + + +ET
Sbjct: 737  NKYEKTIEELSNARNLNTSALQLEH----EHLIKLNQKKDMEIAELKKNIEQMDTDHKET 792

Query: 572  ---------TSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
                        ++T+L  K E  + +L++     Q ++      +R+ ++ R  + +  
Sbjct: 793  KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKD 852

Query: 623  GVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI-EAKAALKQLQEIFEN 681
                 L +   ++  L    +R    Q  S  APV   ++ +++ E  + + QL  I E+
Sbjct: 853  R---SLGSMKEENNHLQEELERLREEQ--SRTAPVADPKTLDSVTELASEVSQLNTIKEH 907

Query: 682  YKKEKAENEKIQNEQ-------LEKLQEQ---VTDLRSQNTKIS---TQLDFASKRYEM- 727
             ++E   ++KI  +Q       L+ LQEQ   + + R Q+ +++   TQL F  K  E+ 
Sbjct: 908  LEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL-FLEKDEEIK 966

Query: 728  -LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLK- 785
             LQ  +E  +   T LHE  Q +        Q     + ++   +EK  +++   E L  
Sbjct: 967  SLQKTIEQIK---TQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023

Query: 786  --KEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843
              KE+E+    E++L  ++   L +Q  Q L    +  +  I+++ + E  Q L ++I  
Sbjct: 1024 GIKEREL----EIKLLNEKNISLTKQIDQ-LSKDEVGKLTQIIQQKDLEI-QALHARISS 1077

Query: 844  LEH--EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNT---KELLKNAQ 898
              H  ++ +L+++L     Q + + R     +L+ K    T  N HL T   K +   A 
Sbjct: 1078 TSHTQDVVYLQQQL-----QAYAMEREKVFAVLNEK----TRENSHLKTEYHKMMDIVAA 1128

Query: 899  KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER---- 954
            KE A +K    N ++    +SS     GQ   +E + +L   +R+ + +++ L ++    
Sbjct: 1129 KEAALIKLQDENKKLSTRFESS-----GQDMFRETIQNLSRIIREKDIEIDALSQKCQTL 1183

Query: 955  ---LKTSTS-------NVEQYQAMV---TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
               L+TS++       N  Q++ ++     L++ + K ++  ++V   ++    ESA+ Q
Sbjct: 1184 LAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1243

Query: 1002 T---QLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELK---KTLSSVQNEVQEALQRAS 1055
                QL+ +++       +LQ D    I+S EQ  ++LK   + L+ VQ+ + +      
Sbjct: 1244 EELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKD 1303

Query: 1056 TALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
              L              K+ + +       L L     E L+A+K +V         L E
Sbjct: 1304 LLL-------------GKLDIISPQLSSASL-LTPQSAECLRASKSEV---------LSE 1340

Query: 1116 TTQKAESQLLECKASWEERERMLK------DEVSKCVCRCEDLEKQNRLLHDQIEKLSDK 1169
            +++  + +L E + S +E++  ++        +S  +    +LE++    H+Q    +D 
Sbjct: 1341 SSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKE---HEQ----TDS 1393

Query: 1170 VVASVKEGVQGPLNVSLSE-----EGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224
             +  +KE  Q  L   L E     + KS + +     F  +  E    R  V  +     
Sbjct: 1394 EIKQLKE-KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNL----- 1447

Query: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
            ++R+ +LE ++ +L+     E EK+  T +      + +++T      M+ + MLR    
Sbjct: 1448 KERILILEMDIGKLK----GENEKIVETYRGKETEYQALQETN-----MKFSMMLR---- 1494

Query: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
              E++ +    K + L  + L  ++   +  E + +L A K + E+ V   + R+Q +++
Sbjct: 1495 --EKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA 1552

Query: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
                         L +K++    +Q    E+ RL+ +  RSN  L   +N +   ++   
Sbjct: 1553 -------------LKQKQMENTALQ---NEVQRLRDKEFRSNQELERLRNHLLESEDSYT 1596

Query: 1405 KVRTEKETIQKDLDAKIIDIQEK-VKTITQVKKIGRRYKTQYEELKAQQDKVM----ETS 1459
            +     E  +  L  K+  ++EK V +   ++    +   Q E L+ Q + V     ET+
Sbjct: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656

Query: 1460 AQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES-QVENLQKTLSEKETEARNLQEQT 1518
             Q S   ++       +  L+  L   + + K++ S ++E  ++ ++E +  A NL+ + 
Sbjct: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKV 1716

Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
            + LQ  L      L   +    +L +Q+  KEE+                          
Sbjct: 1717 ISLQECLDEANAALDSAS----RLTEQLDVKEEQI------------------------- 1747

Query: 1579 EELKQRNGALDQQKDELDVRITALKSQYEGRISRL 1613
            EELK++N    +  D++  ++ +L +  EG++ ++
Sbjct: 1748 EELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782



 Score =  172 bits (436), Expect = 4e-42
 Identities = 344/1695 (20%), Positives = 689/1695 (40%), Gaps = 300/1695 (17%)

Query: 118  EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
            EE+EAE  D        ++E+E +   ++  NE+LK+  T   E   +  E+Q    S  
Sbjct: 43   EEVEAELPD------SRTKEIEAIHAILRSENERLKKLCTDLEEKH-EASEIQIKQQSTS 95

Query: 178  YREKRLEQEKELLH--SQNTWLNTEL-----------------KTKTDELLALGREKG-- 216
            YR +  ++E E+ H  ++   L  +L                  T      A G      
Sbjct: 96   YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155

Query: 217  ---------NEILELKCNLENKKEEVSRLEEQMN------------GLKTSNEHLQKHVE 255
                      +I+  +  +     EVSRLE ++             G   S++     ++
Sbjct: 156  AFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQ 215

Query: 256  DLLTKLKEAKEQQASMEEKFHNEL-NAH----IKLSNLYKSAADDSEAKSNELTRAVEEL 310
            +++ +LK+ + Q+    +   + L NAH     ++S  ++    D E +       +EEL
Sbjct: 216  NIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEER-------IEEL 268

Query: 311  HKLLKEAGEANKAIQDHLLEVEQSKD-----QMEK-EMLEKIGRLEKELENANDLLSATK 364
              LL++ G     I+  L ++ + +      Q+EK E  +K+ +LE ++++ N  LS+ +
Sbjct: 269  ENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAE 326

Query: 365  RKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI--NKY 422
                IL  E+                            +  + + ++E+ EN ++  +K 
Sbjct: 327  NDRDILRREQ--------------------------EQLNVEKRQIMEECENLKLECSKL 360

Query: 423  LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
                VK+ +          +E   AQ A      +L+QA+ + +         N+ +S+ 
Sbjct: 361  QPSAVKQSDTMT------EKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLA 414

Query: 483  ERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEE------VSSADISSSSEVISQH 536
            E DN +++++++ L ++  +L  E EE + + +  + E       ++ DIS  SE+    
Sbjct: 415  E-DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473

Query: 537  LVSYRNIEELQQ---QNQRLLVALRELGETREREEQETTS------SKITELQLKLESAL 587
            L      +EL Q   + + L+  + EL    +R+ QE T        ++++ Q + +S +
Sbjct: 474  LNLEAKEQELNQSISEKETLIAEIEEL----DRQNQEATKHMILIKDQLSKQQNEGDSII 529

Query: 588  TELEQ-LRKSRQHQMQLVDS---IVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK 643
            ++L+Q L   ++   QL D    I ++ D+ +  L Q+      LH              
Sbjct: 530  SKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHL------------- 576

Query: 644  RPSTSQTVSTPAPVPVIESTEAIEAKAAL-KQLQEIFENYKKEKAENEKIQNEQLEKLQE 702
               T Q +       V +  ++ E+  ++ K+  E+ E+ ++ + E  +I+NE ++ L +
Sbjct: 577  ---TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633

Query: 703  QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762
                  + N K     D   K  E    N++    E+  L+E  +K+    + + + +  
Sbjct: 634  D----SNSNFK-----DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL 684

Query: 763  MTQDLR--------GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
              +D+R        G N+         E LK EK  +   E  L   ++ LL E      
Sbjct: 685  ACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI---EAELCWAKKRLLEEANKYEK 741

Query: 815  LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
             +  L   + +   +     + L    +K + EI+ LKK +E +++  H  T+++    L
Sbjct: 742  TIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIE-QMDTDHKETKDVLSSSL 800

Query: 875  DTKRQLDTETNLHL----NTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSN 930
            + ++QL    N         KE     Q+E+    Q L   E+    Q+ +   +   S 
Sbjct: 801  EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI--LRQTIEEKDRSLGSM 858

Query: 931  KEDVDDLVSQLRQTEEQ------VNDLK--ERLKTSTSNVEQYQAMVTSLEESLNKEKQV 982
            KE+ + L  +L +  E+      V D K  + +    S V Q   +   LEE +   +++
Sbjct: 859  KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918

Query: 983  TEE-------VRKNIEVRLKESAEFQTQLEKKLM---EVEKEKQELQDDKRRAIESMEQQ 1032
             E+       + ++++ + KE  EF+ Q E+      ++  EK E     ++ IE ++ Q
Sbjct: 919  IEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQ 978

Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL-MLHAA 1091
            L E ++ + +  +++ +  +  S  + N  +     + + +  V+   + E E+ +L+  
Sbjct: 979  LHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEK 1038

Query: 1092 DVEAL----QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWE-----ERERMLKDEV 1142
            ++       Q +K++V K+  + Q  +   Q   +++     + +     ++ +    E 
Sbjct: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER 1098

Query: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPL---NVSLSEEGKSQEQ---- 1195
             K      +  ++N  L  +  K+ D V A  KE     L   N  LS   +S  Q    
Sbjct: 1099 EKVFAVLNEKTRENSHLKTEYHKMMDIVAA--KEAALIKLQDENKKLSTRFESSGQDMFR 1156

Query: 1196 -ILEILRFIRREKEI--------AETRFEVAQVES-------LRYRQRVELLER--ELQE 1237
              ++ L  I REK+I         +T   V Q  S       +   Q  ELL+   +L++
Sbjct: 1157 ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ 1216

Query: 1238 LQDSLNAEREKVQVTAKTMAQHE------ELMKKTETMNVVMETNKMLREEKERLEQDLQ 1291
                +   +++V  T + M QHE      EL +    + V  + N  L+ +   L Q  +
Sbjct: 1217 QVKKMEEWKQQVMTTVQNM-QHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYE 1275

Query: 1292 QMQAKVRKLELDILPLQEANAELSEK-----------SGMLQAEKKLLEEDVKRWKARNQ 1340
            Q + K++    ++  +Q +  +L              S  L +   L  +  +  +A   
Sbjct: 1276 QNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKS 1335

Query: 1341 HLVSQQKD---PDTEEYRKLLSEKEVHTKRIQQLTEEIG---RLKAEIARSNASLTNNQN 1394
             ++S+  +    + EE RK L EK+   + +Q+    +       +E+ R     T+++ 
Sbjct: 1336 EVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSE- 1394

Query: 1395 LIQSLKED---LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE---- 1447
             I+ LKE    L K+  EK+ + K    +++   E         ++ R+  T  +E    
Sbjct: 1395 -IKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILI 1453

Query: 1448 -------LKAQQDKVMETSAQSSGDHQ--------------EQHVSVQEMQE-------- 1478
                   LK + +K++ET      ++Q              E+      M+E        
Sbjct: 1454 LEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQL 1513

Query: 1479 LKET-------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQD 1531
            LKE        LNQ     KS++ +    Q+   +     +  Q +   LQ+E+ RLR D
Sbjct: 1514 LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLR-D 1572

Query: 1532 LQDRTTQE-EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
             + R+ QE E+LR  + E E+   +  +AA+ + A L   + ++T   E+L   + A++ 
Sbjct: 1573 KEFRSNQELERLRNHLLESEDSYTREALAAEDREAKL---RKKVTVLEEKLVSSSNAMEN 1629

Query: 1591 QKDELDVRITALKSQ 1605
               +  V++ +L+ Q
Sbjct: 1630 ASHQASVQVESLQEQ 1644



 Score =  138 bits (347), Expect = 7e-32
 Identities = 193/1002 (19%), Positives = 416/1002 (41%), Gaps = 115/1002 (11%)

Query: 725  YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            + +L+   E  ++  T L E+++      ++Q        Q      +++ ++ ++A  +
Sbjct: 61   HAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ-----KEVEISHLKARQI 115

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ--IE 842
              + ++LKL     S    + +      +     +          + +    +SSQ  I 
Sbjct: 116  ALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN 175

Query: 843  KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
            +L +E+S    +LE+EV     + +    Q  D   Q +    L    KEL +N  +EI 
Sbjct: 176  RLSNEVS----RLESEVGHWRHIAQTSKAQGTDNSDQSEI-CKLQNIIKELKQNRSQEID 230

Query: 903  TLKQHLS---NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQ-----TEEQVNDLKER 954
              +  +S   N   Q  ++ S+R  +     +E +++L + L+Q      E  ++ + E 
Sbjct: 231  DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290

Query: 955  LKT----------STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQL 1004
             KT          ST  +EQ +  +  + + L+  +   + +R+  E    E  +   + 
Sbjct: 291  QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEEC 350

Query: 1005 EKKLMEVEK------EKQELQDDKRRAI--ESMEQQLSELKKTLSSVQNEVQEALQRAST 1056
            E   +E  K      ++ +   +K R +   +  +++  L++ LS  +NE+         
Sbjct: 351  ENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMR------- 403

Query: 1057 ALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEET 1116
             LS+  Q     ++  K+ +  +   E+E  L + + E LQ +  +++    V +     
Sbjct: 404  -LSSLNQDNSLAEDNLKLKMRIE-VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATR 461

Query: 1117 TQKAESQLLECKASWEERERMLKDEVSK---CVCRCEDLEKQNRLLHDQIEKLSDKVVAS 1173
                +S+L + + + E +E+ L   +S+    +   E+L++QN+     +  + D++   
Sbjct: 462  DISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQ 521

Query: 1174 VKEG--VQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELL 1231
              EG  +   L   L++E K   Q+ +    I +E ++ + +   ++V         + L
Sbjct: 522  QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581

Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
            E +++ L D LN  +E     +    Q E L  K        E +++  E  + L QD  
Sbjct: 582  EDKVENLVDQLNKSQE-----SNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSN 636

Query: 1290 -------LQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL 1342
                   L++ +A+VR L+ ++  L++ N  L           K +  DVK     N+ L
Sbjct: 637  SNFKDTLLKEREAEVRNLKQNLSELEQLNENL-----------KKVAFDVKM---ENEKL 682

Query: 1343 VSQQKDPDTEEYRKLLSEKEVHTKR---IQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
            V   +D   +    L    ++  ++   ++ L  E G ++AE+  +   L    N  +  
Sbjct: 683  VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKT 742

Query: 1400 KEDLNKVRT-EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMET 1458
             E+L+  R      +Q + +  I   Q+K   I ++KK   +  T ++E K      +E 
Sbjct: 743  IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE 802

Query: 1459 SAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQT 1518
              Q +    ++ + +++++E    L +   K      + E L++T+ EK+    +++E+ 
Sbjct: 803  QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862

Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKE- 1577
              LQ EL RLR++ Q RT             + KT  ++    S+++ L  +K+ L +E 
Sbjct: 863  NHLQEELERLREE-QSRTA---------PVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912

Query: 1578 ----------NEELKQRNGALDQQKDELD----------VRITALKSQYEGRISRLEREL 1617
                      N+   Q   +L +QK E+D             T L  + +  I  L++ +
Sbjct: 913  KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTI 972

Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
             + + +  E+R + Q  ++ + ++ +  +L     S +  ++
Sbjct: 973  EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLS 1014



 Score =  100 bits (250), Expect = 1e-20
 Identities = 189/952 (19%), Positives = 406/952 (42%), Gaps = 120/952 (12%)

Query: 3    AVLQQVLERTELNKLPKSVQNKL---EKFLADQ-QSEIDGLKGRHEKFKVESEQQYFEIE 58
            +V +   E ++LN + + ++ ++   +K + DQ QS++  L+   E+ K   E +Y   +
Sbjct: 890  SVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQ 949

Query: 59   KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
               +H+Q   + +  E +SL+  +E++  QL    E+ ++++   + +I  +++      
Sbjct: 950  MNATHTQ-LFLEKDEEIKSLQKTIEQIKTQLH---EERQDIQ-TDNSDIFQETKVQSLNI 1004

Query: 119  ELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE-------LQ 170
            E  +EK DL +   ERL + ++    ++K LNEK    + TK   QL  DE       +Q
Sbjct: 1005 ENGSEKHDLSKAETERLVKGIKERELEIKLLNEK--NISLTKQIDQLSKDEVGKLTQIIQ 1062

Query: 171  ASDVSVKYREKRLEQEKELLHSQNT-WLNTELKT---KTDELLALGREKGNEILELKCNL 226
              D+ ++    R+       H+Q+  +L  +L+    + +++ A+  EK  E   LK   
Sbjct: 1063 QKDLEIQALHARISSTS---HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEY 1119

Query: 227  ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL-----------LTKLKEAKEQQASMEEKF 275
                + V+  E  +  L+  N+ L    E             L+++   K+ +     + 
Sbjct: 1120 HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQK 1179

Query: 276  HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSK 335
               L A ++ S+    A   +  +  EL +  ++L + +K+  E  + +   +  ++   
Sbjct: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHES 1239

Query: 336  DQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
             Q+++E+ +   ++  + +N + L       G I S E+            K+   G +L
Sbjct: 1240 AQLQEELHQLQAQVLVDSDNNSKL--QVDYTGLIQSYEQNET---------KLKNFGQEL 1288

Query: 396  TELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
             ++ ++  +   T+D LLL KL+          I+    + A +L  Q  E  RA K+  
Sbjct: 1289 AQVQHSIGQLCNTKD-LLLGKLD----------IISPQLSSASLLTPQSAECLRASKSEV 1337

Query: 453  SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
             LS   E   +E++ L++   + +     L+ +N R+   +   S        ELE  R 
Sbjct: 1338 -LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS--------ELE--RK 1386

Query: 513  NHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETT 572
             H   D E+         + + Q L+  +++  ++ ++ +LL +      T +  E E  
Sbjct: 1387 EHEQTDSEIKQL---KEKQDVLQKLLKEKDLL-IKAKSDQLLSSNENF--TNKVNENELL 1440

Query: 573  SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
               +T L+ ++     ++ +L+   +   ++V++   +   Y+ L       ++ L    
Sbjct: 1441 RQAVTNLKERILILEMDIGKLKGENE---KIVETYRGKETEYQALQETNMKFSMMLREKE 1497

Query: 633  LDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKI 692
             +  S+    K  +  Q +         E  + + A  ++++   +F+  + +     K 
Sbjct: 1498 FECHSMKE--KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQ 1555

Query: 693  QNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTAT 752
            +  +   LQ +V  LR +  + + +L+   +    L ++ + Y RE  +  +R  KL   
Sbjct: 1556 KQMENTALQNEVQRLRDKEFRSNQELE---RLRNHLLESEDSYTREALAAEDREAKLRKK 1612

Query: 753  TQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ 812
                E+ + + +  +  A+ +   A V+ E+L+++  ++       + Q  S+  EQ  Q
Sbjct: 1613 VTVLEEKLVSSSNAMENASHQ---ASVQVESLQEQLNVVSKQRDETALQL-SVSQEQVKQ 1668

Query: 813  NLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLEN--------------- 857
              L  +L  +Q +LE  + E K   S+++EK +  I+  KK  EN               
Sbjct: 1669 YAL--SLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEA 1726

Query: 858  --EVEQRHTLTRNLDV---QLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
               ++    LT  LDV   Q+ + KRQ +         +E+L + QK++ +L
Sbjct: 1727 NAALDSASRLTEQLDVKEEQIEELKRQNELR-------QEMLDDVQKKLMSL 1771


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score =  202 bits (514), Expect = 3e-51
 Identities = 377/1878 (20%), Positives = 782/1878 (41%), Gaps = 276/1878 (14%)

Query: 9    LERTELNKLPKSVQNKLEKFLADQQS--------------EIDGLKGRHEKFKVESEQQY 54
            L + E+N+L    Q  +       QS              E++       KF+ + + + 
Sbjct: 32   LSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKV 91

Query: 55   FEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFT 114
             ++E  L  +Q+      R+ + LR E+ +L  QL+    + +++E   ++   +  Q  
Sbjct: 92   MKLENELEMAQQSAGG--RDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLA 149

Query: 115  RTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
               EE E E   L R N+RL ++ E L +D+    +++     T     L     + SD 
Sbjct: 150  LRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKET-----LLSRRGEDSDY 204

Query: 175  SVKYREKRLEQEKELLHSQN-TWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEV 233
              +  +K  E  + L   Q  T  N +++ +  E+     E   E+ ++       K  V
Sbjct: 205  RSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIV 264

Query: 234  SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAA 293
             + +  ++ LK  N+H Q  V++L   LK   E+    ++     +NA ++   L  S+ 
Sbjct: 265  HQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEE----DDPIMVAVNAKVEEWKLILSSK 320

Query: 294  DDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
            DD   +  ++   + E  KL     +A+K+    L +  Q +D   K + E++ +  KE+
Sbjct: 321  DDEIIEYQQMLHNLRE--KLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEM 378

Query: 354  ENANDLLSATK-----RKGA-ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
            E    ++   K      KGA  LS++    +  T   + +  K   +  EL  A    +D
Sbjct: 379  EKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKD 438

Query: 408  QLLLEKLENKRINKY------LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA 461
            + L+E L  KR+  Y      L++ V E++     +K +  E E   K +  L +K+   
Sbjct: 439  KELVEAL--KRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDF 496

Query: 462  MKEIQRLQEDTDKANK---------------------QSSVLERDNRRMEIQVKDLSQQI 500
            + E + L+E      K                     ++ +L ++   +E +  DL ++I
Sbjct: 497  LDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKI 556

Query: 501  RVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH---LVSYRNIEELQQQNQRLLVAL 557
            R +  E  +      +  E+++  +  S  + IS+    L+S +N+ E Q +N+ L    
Sbjct: 557  RQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFL---S 613

Query: 558  RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
            REL E  +  + E + + I + Q KL+  + E +QL +  +  +Q +  + +  D    +
Sbjct: 614  RELIE--KERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPD----V 667

Query: 618  LSQTTGVAIP-----------LHASSLDDVSL-------ASTPKRPSTSQTVSTPAPVPV 659
                T + IP            +A  + D SL         T +     Q +       +
Sbjct: 668  KGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAI 727

Query: 660  IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK--LQEQVTDLRSQN---TKI 714
              S +  +A   +  L++     ++ +  N   +   L         + + SQN     +
Sbjct: 728  NYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHL 787

Query: 715  STQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKL 774
              +L+   K+ + L+D++E Y R+   +  +   L      +++   T ++ ++    KL
Sbjct: 788  LQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKL 847

Query: 775  AVAEVRAENLKKEKEMLKLSEVRL-SQQRESLLAEQRGQNLLLTNLQTIQGILERSET-- 831
               +V+ + +K ++    L+ +++ S + + +LAE   +   +T LQ  +  L R  T  
Sbjct: 848  E-DQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRK---ITVLQVNEKSLIRQYTTL 903

Query: 832  -ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD-TKRQLDTETNLHLN 889
             E +++L  + EK ++E+  ++ ++    E+   L R  ++ +      Q   + ++ L+
Sbjct: 904  VELERQLRKENEKQKNELLSMEAEV---CEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS 960

Query: 890  TKELLKNAQKEIATLKQHL---SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
              EL      E+    + +    NM VQ  S + +       S KE V+ +  +L  T+E
Sbjct: 961  ELELANKQYNELTAKYRDILQKDNMLVQRTS-NLEHLECENISLKEQVESINKELEITKE 1019

Query: 947  QVNDLKERLKTST-----------------SNVEQYQAMVTSLEESLNKEKQVTEEVRK- 988
            +++ +++  +  T                 S++      +T LE     E+Q  E  +K 
Sbjct: 1020 KLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKM 1079

Query: 989  --NIEVRLKESAEFQTQLEKKLMEVEK-----------EKQELQDDKRRAIESME-QQLS 1034
              ++   LK+  E   +LE K  E+ K            + EL D   +A+   + Q++ 
Sbjct: 1080 YEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL 1139

Query: 1035 ELKKTLSSVQNEVQEA-----LQRASTALSNEQQARRD--------------CQEQAKIA 1075
            EL+K    ++ EV +      + R    + N QQ  RD               Q   K  
Sbjct: 1140 ELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSL 1199

Query: 1076 VEAQNKYERELML-HAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
            +   +++   L L  A  +  L++   ++ KM +    LE+   + E  L   +     R
Sbjct: 1200 IAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNR 1259

Query: 1135 ERMLK-------------------DEVSKCVCRC----------------EDLEKQNRLL 1159
             + L+                   ++ SK + +                 E    +N+ L
Sbjct: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTL 1319

Query: 1160 HDQIE-KLSDKVVASVKE--GVQGPLNVSLS-EEGKSQEQILEILRFIRREKE------- 1208
              +++ K  +++++++K+  G Q  +N  +  EE + QE  L++ R + ++KE       
Sbjct: 1320 EMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE--LKLNRELVKDKEEIKYLNN 1377

Query: 1209 -IAETRFEVAQVE-------------SLRYRQRVELLEREL----QELQDSLNAEREKVQ 1250
             I+E    ++ +E              + + QR   LER+L    ++  + LNA ++  +
Sbjct: 1378 IISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEE 1437

Query: 1251 VTAK-------TMAQHEELMKK-TETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL 1302
             T            Q E  ++K  E + +++ET    R   + LE+ L++ ++ +R  E 
Sbjct: 1438 ATGSIPDPSLPLPNQLEIALRKIKENIRIILET----RATCKSLEEKLKEKESALRLAEQ 1493

Query: 1303 DILPLQEANAELSEK-SGMLQAEKKLLEEDVKRWKARNQHLVS-------------QQKD 1348
            +IL   +   EL  +     + EK + E   K  + ++ H +               QK+
Sbjct: 1494 NILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKE 1553

Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEE---IGRLKAEIARSNASLTNNQNLIQSLKEDLNK 1405
               ++Y++LL +     + I +  EE   I   + E+   ++     Q     +K+    
Sbjct: 1554 EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTP 1613

Query: 1406 VRTEKETIQ-KDLDAKIIDIQEKVKT-ITQVKKIGRRYKTQYE--ELKAQQDKVMETSAQ 1461
            V T K  I+  +++  + +  + + + + ++KK+ +  + Q E  ELK ++ + ++   Q
Sbjct: 1614 VPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQ 1673

Query: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA-RNLQEQTVQ 1520
             + + + + V   E+++LK  L+Q++ +S+ L+S+++  ++  S   T   RNL E   +
Sbjct: 1674 ENHEDEVKKVKA-EVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVE---R 1729

Query: 1521 LQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEE 1580
            L+S+L+   +  +  +    +LR ++T   E+  + I A   K AHL  V+  + +   E
Sbjct: 1730 LKSQLALKEKQQKALSRALLELRAEMTAAAEE--RIISATSQKEAHL-NVQQIVDRHTRE 1786

Query: 1581 LKQRNGALDQQKDELDVRITALKSQYEG---RISRLERELREHQERHLEQRDEPQEPSNK 1637
            LK +   L++   +L   +   K++       ++ L  EL++ Q+ + +   E +E   +
Sbjct: 1787 LKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQE 1846

Query: 1638 VPEQQRQITLKTTPASGE 1655
              E +RQI   T+   G+
Sbjct: 1847 NDELKRQIKRLTSGLQGK 1864



 Score =  173 bits (439), Expect = 2e-42
 Identities = 371/1820 (20%), Positives = 741/1820 (40%), Gaps = 286/1820 (15%)

Query: 29   LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQ 88
            L +  S+ D +  R  K  + S +   E + +       L+ + R+ +  R  + K  N+
Sbjct: 579  LTENISQGDRISER--KLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636

Query: 89   LKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELE--------- 139
            LK L E+NK+LE      +    +  +  +    E   +I + ERL   +E         
Sbjct: 637  LKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696

Query: 140  ----------YLTEDVKRLNEKLKESNTTK-------GELQLKLDELQASDVSVKYRE-- 180
                       LT   + L ++L+ES            +  LK+D L+     ++  E  
Sbjct: 697  ASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGS 756

Query: 181  ----KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR- 235
                K ++    +  S  + +N++     + L+ L +E  N+  +LK NLE+  E+ +R 
Sbjct: 757  NVVFKGIDLPDGIAPSSASIINSQ----NEYLIHLLQELENKEKKLK-NLEDSLEDYNRK 811

Query: 236  ----------LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNA-HIK 284
                      L ++    K + +   K +++   KL++  +Q A   ++++N LNA  + 
Sbjct: 812  FAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMD 871

Query: 285  LSNLYKSAADDS------EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQM 338
               + K  A++S      +     L R    L +L ++  + N+  ++ LL        M
Sbjct: 872  SDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLS-------M 924

Query: 339  EKEMLEKIGRLEKELENANDLLSATKR---KGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
            E E+ EKIG L++  E A   ++A ++       LSE ELA             K   +L
Sbjct: 925  EAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELAN------------KQYNEL 972

Query: 396  TELYNAYVETQDQLL-----LEKLE--NKRINKYLDEIVKEVEAKAPILKRQREEYE--- 445
            T  Y   ++  + L+     LE LE  N  + + ++ I KE+E     L    + +E   
Sbjct: 973  TAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET 1032

Query: 446  ---------RAQKAVAS---LSVKLEQAMKEIQRLQED--TDKANKQSSVLERDNRRMEI 491
                     +A+K++ +   +S+  +  M E++ L E    +   K    L    ++ME 
Sbjct: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092

Query: 492  QVKDLSQQIRVLL-MELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
            +  +L  +   L  + L+  +   ++RDE   S   + S     + L   +N  EL+ + 
Sbjct: 1093 RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEV 1152

Query: 551  QRLLVALRELGETRERE------EQETTSSKITELQLKL---ESALTELEQLRKSRQHQM 601
             +L    RE+ +   R+      +Q++   ++  L+++L   ++   E   + K  QH +
Sbjct: 1153 SKL----REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNV 1208

Query: 602  QL-------------VDSIVRQRDMYRILLSQTTGVAIP-LHASSLDDVSLASTPKRPST 647
             L             + S +++ + Y + L Q        L+ + L+  + A   ++   
Sbjct: 1209 SLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQ 1268

Query: 648  SQTVSTPAPVPVIESTEAIEAKAALKQLQ-EIFENYKKEKAENEKIQNEQLEK------L 700
            S        +P+ +  +  +    L+  + +I +  K  + E+  ++N+ LE       L
Sbjct: 1269 SLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGL 1328

Query: 701  QE-------------------QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITS 741
            +E                   ++ +LR Q  K++ +L    +  + L + +  Y R I+S
Sbjct: 1329 EELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISS 1388

Query: 742  L----------HERNQ----KLTATTQKQEQIINTMTQDLRGANEKLAVA---------- 777
            L          HE  Q    +     ++Q  I +    ++  A +K   A          
Sbjct: 1389 LEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLP 1448

Query: 778  -----EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETE 832
                 E+    +K+   ++  +        E L  ++    L   N+ +   ++     E
Sbjct: 1449 LPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVIN----E 1504

Query: 833  TKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKE 892
             + RL +  E+ E  I+ L +K E E +  HTL +     + + + +L+ +  +    + 
Sbjct: 1505 LRLRLPATAER-EKLIAELGRK-EMEPKSHHTL-KIAHQTIANMQARLNQKEEVLKKYQR 1561

Query: 893  LLKNAQKEIATL-KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDL 951
            LL+ A++E   + K+H  ++ + +  +   +        K+   DL+ Q   T    N  
Sbjct: 1562 LLEKAREEQREIVKKHEEDLHI-LHHRLELQADSSLNKFKQTAWDLMKQ-SPTPVPTNKH 1619

Query: 952  KERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQL-EKKLME 1010
              RL      V +    ++SL   L K  Q  E  R+  E+++KE    + QL E    E
Sbjct: 1620 FIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDE 1679

Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
            V+K K E++D K    +S ++      + L S     +EA  RA T        R   + 
Sbjct: 1680 VKKVKAEVEDLKYLLDQSQKE-----SQCLKSELQAQKEANSRAPTTTMRNLVER--LKS 1732

Query: 1071 QAKIAVEAQNKYERELM-----LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ-- 1123
            Q  +  + Q    R L+     + AA  E + +A  Q     +V+Q ++  T++ ++Q  
Sbjct: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVE 1792

Query: 1124 --------LLECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLH--DQIEKLSDKVVA 1172
                    L E   + + RE  L D ++      +  +K  N++L   ++I++ +D++  
Sbjct: 1793 DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKR 1852

Query: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
             +K    G     L++    Q  I E+ R +++ +   E + E   ++ ++ +   E L 
Sbjct: 1853 QIKRLTSGLQGKPLTD--NKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELI 1910

Query: 1233 R--ELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDL 1290
            R  E ++ Q  +   R K++       +  E+   T+ +N + +      +EK  L++ L
Sbjct: 1911 RWEEGKKWQAKIEGIRNKLK------EKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKL 1964

Query: 1291 --------QQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDV-------KRW 1335
                    Q +  +  + E ++  L++ N +L      ++A + L  + V        R+
Sbjct: 1965 KTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRY 2024

Query: 1336 KARNQHLVSQQKDPDTEEYRKLLS-EKEVHTKRIQQLTEEIGRLKAE-------IARSNA 1387
                 H + +Q   DT     +   E + H +R Q+L +E  +L +E       + ++N 
Sbjct: 2025 LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANK 2084

Query: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDL------DAKIIDIQEKVKTITQVKKIGRRY 1441
             L   +N ++ LKE    ++ EK  +Q+ L            I E  KTI  +KK+  + 
Sbjct: 2085 DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKV 2144

Query: 1442 KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA-----ETKSKSLE-- 1494
            + + E+LK      + TS + +   QE      E+++LK  L        E+K+K  E  
Sbjct: 2145 QRENEQLKKASG--ILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI 2202

Query: 1495 -SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD---RTTQEEQLRQQITEKE 1550
             ++ E L+K L ++   A  L+     L+    ++   L++   R    E    Q+   +
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGAD 2262

Query: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENE----------ELKQRNGALDQQKDELDVRIT 1600
             K+ K+IV  +     L  ++  + K+N+          E  +R   +++  ++L+ +I 
Sbjct: 2263 SKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIK 2322

Query: 1601 ALKSQYEGRISR--LERELR 1618
             LK   EG  +   L+REL+
Sbjct: 2323 ILKHVPEGAETEQGLKRELQ 2342



 Score =  171 bits (432), Expect = 1e-41
 Identities = 327/1604 (20%), Positives = 662/1604 (41%), Gaps = 223/1604 (13%)

Query: 49   ESEQQYFEIEKRLSHSQERLVN-ETRECQ--SLRLELEKLNNQLKALTEKNKELEIAQDR 105
            E   +Y +I ++ +   +R  N E  EC+  SL+ ++E +N +L+   EK   +E A ++
Sbjct: 971  ELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQ 1030

Query: 106  NIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLK 165
               + ++ +  K +      D++  +++++        ++K LNE+ +  +  K    L+
Sbjct: 1031 ETKLGNESSMDKAKKSITNSDIVSISKKITML------EMKELNERQRAEHCQKMYEHLR 1084

Query: 166  LDELQASDVSVKYREKRLEQEKELLHSQNT--WLNTELKTKTDELLALGREKGNEILELK 223
                Q  + + +   K  E  K  L +Q     L  EL     +  A+       ILEL+
Sbjct: 1085 TSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSK--AVSDADRQRILELE 1142

Query: 224  CNLENKKEEVSRLEE-------QMNGLKTSNEHLQKHVEDLLTKLKE--AKEQQASMEEK 274
             N    K EVS+L E       Q+  L    +   K VE L  +L +  A+  + S+  K
Sbjct: 1143 KNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAK 1202

Query: 275  FHNELNAHIKLSNL--------YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
             H   N  ++LS            S     EA +  L + ++E  + L  A    +    
Sbjct: 1203 LHQH-NVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261

Query: 327  HLLEVEQS-------------KDQMEKEMLEKIG---RLEKELENAND---------LLS 361
            HL +  QS             +++  K M++      ++ +E++N+           L  
Sbjct: 1262 HLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEM 1321

Query: 362  ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINK 421
              K KG     EEL +         K++   MK+ EL    ++   +L+ +K E K +N 
Sbjct: 1322 ELKLKGL----EELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNN 1377

Query: 422  YLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQ--- 478
             + E  + + +    + +Q + +E  Q A     V LE+ +    R Q +   A ++   
Sbjct: 1378 IISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEE 1437

Query: 479  --SSVLERD---NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVI 533
               S+ +       ++EI ++ + + IR++L      +       E+ S+  ++  + + 
Sbjct: 1438 ATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILS 1497

Query: 534  SQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQ 592
               +++   +       +  L+A  ELG  +E E +   + KI    +  +++ L + E+
Sbjct: 1498 RDKVINELRLRLPATAEREKLIA--ELGR-KEMEPKSHHTLKIAHQTIANMQARLNQKEE 1554

Query: 593  LRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVS 652
            + K  Q  ++       + +   I+      + I  H   L   S  +  K+ +      
Sbjct: 1555 VLKKYQRLLEKA-----REEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQ 1609

Query: 653  TPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNT 712
            +P PVP  +            +L E+    ++  AE +   +  L KL++   DL  Q  
Sbjct: 1610 SPTPVPTNKH---------FIRLAEM----EQTVAEQDDSLSSLLVKLKKVSQDLERQRE 1656

Query: 713  KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
                ++         LQ+N E   +++ +  E  + L   +QK+ Q + +  Q  + AN 
Sbjct: 1657 ITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS 1716

Query: 773  KLAVAEVR--AENLK-----KEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ----- 820
            +     +R   E LK     KEK+   LS   L  + E   A +  + ++    Q     
Sbjct: 1717 RAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAE--ERIISATSQKEAHL 1774

Query: 821  TIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
             +Q I++R   E K    +Q+E L   +  LK+ L+    + ++LT NL+          
Sbjct: 1775 NVQQIVDRHTRELK----TQVEDLNENLLKLKEALKTSKNRENSLTDNLN---------- 1820

Query: 881  DTETNLHLNTKELLKNA-QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED-VDDLV 938
              + N  L  K+   N   +E   + Q    ++ Q+   +S   GK    NK+  +++L 
Sbjct: 1821 --DLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQ 1878

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
             ++++ E Q+    E +       +  +  +   EE    + ++ E +R  ++ +  E  
Sbjct: 1879 RKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKI-EGIRNKLKEKEGEVF 1937

Query: 999  EFQTQLE--KKLM-EVEKEKQELQDDKR------------RAIESMEQQLSELKKTLSSV 1043
                QL   K L  + +KEK  LQ   +            RA+ES E++L ELKK    +
Sbjct: 1938 TLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALES-EKELEELKKRNLDL 1996

Query: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA--AKE 1101
            +N++     RA  AL  +              +  QN+Y +E  LHA + +  +   +K 
Sbjct: 1997 ENDI--LYMRAHQALPRDSVVED---------LHLQNRYLQE-KLHALEKQFSKDTYSKP 2044

Query: 1102 QVSKMASV-----RQHLEETTQKAESQLLECKASWEERER---MLKDEVSKCVCRCEDLE 1153
             +S + S       Q L++   K  S+ +E K   E+  +    LK++V      CE L+
Sbjct: 2045 SISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLK 2104

Query: 1154 KQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETR 1213
            K+      ++++    V  S + G   P      E  K+   + +++  ++RE E     
Sbjct: 2105 KEKA----EVQRKLGHVRGSGRSGKTIP------ELEKTIGLMKKVVEKVQRENE----- 2149

Query: 1214 FEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQV-TAKTMAQHEELMKKTETMNVV 1272
             ++ +   +   +++  +E+E     + L AE EK++      ++ H E   KT+    +
Sbjct: 2150 -QLKKASGILTSEKMANIEQE----NEKLKAELEKLKAHLGHQLSMHYE--SKTKGTEKI 2202

Query: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDV 1332
            +  N+ LR+E ++     ++++     LE+           L+EK  +       LEE  
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEI-----------LNEKMTVQ------LEETG 2245

Query: 1333 KRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNN 1392
            KR +        Q +  D++ ++ ++  +   TK        +  L+ +IA+ N S+T+ 
Sbjct: 2246 KRLQFAESR-GPQLEGADSKSWKSIVVTRMYETK--------LKELETDIAKKNQSITDL 2296

Query: 1393 QNLIQSLKEDLNKVRTEKETIQKDLDAKIID-IQEKVKTITQVKK---IGRRYKTQYEEL 1448
            + L++   E   KV    E +++ +  KI+  + E  +T   +K+   + R    Q ++ 
Sbjct: 2297 KQLVKEATEREQKVNKYNEDLEQQI--KILKHVPEGAETEQGLKRELQVLRLANHQLDKE 2354

Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKE 1508
            KA+    +E +   SG       ++ +  +LKE +   ET+ K  + + ++L++ + + +
Sbjct: 2355 KAELIHQIEANKDQSGAES----TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK 2410

Query: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552
             E  N      +   E+  L+ + ++   +   L +++ +  E+
Sbjct: 2411 KELENFDPSFFE---EIEDLKYNYKEEVKKNILLEEKVKKLSEQ 2451



 Score =  121 bits (304), Expect = 7e-27
 Identities = 259/1299 (19%), Positives = 530/1299 (40%), Gaps = 205/1299 (15%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE 66
            Q L R     LP + Q K  K +   Q++         K K+  E +  + E R      
Sbjct: 1268 QSLRRQFSGALPLAQQEKFSKTMIQLQND---------KLKIMQEMKNSQQEHR------ 1312

Query: 67   RLVNETRECQSLRLELEKLNNQLKALTEKNK------ELEIAQDRNIAIQSQFTRTKEEL 120
             + N+T E +     LE+L + LK      K      ++E  + + + +  +  + KEE+
Sbjct: 1313 NMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEI 1372

Query: 121  EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
            +     +      +S   E + +  K   E+    +  + +L+ +LD        +    
Sbjct: 1373 KYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAA 1432

Query: 181  KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
            ++ E+    +   +  L  +L+    ++    +E    ILE +   ++ +E   +L+E+ 
Sbjct: 1433 QKFEEATGSIPDPSLPLPNQLEIALRKI----KENIRIILETRATCKSLEE---KLKEKE 1485

Query: 241  NGLKTSNEHL---QKHVEDLLTKLKEAKEQQA--------SMEEKFHNELN-AHIKLSNL 288
            + L+ + +++    K + +L  +L    E++          ME K H+ L  AH  ++N+
Sbjct: 1486 SALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANM 1545

Query: 289  YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR 348
                    +A+ N+    +++  +LL++A E  + I          K + +  +L    R
Sbjct: 1546 --------QARLNQKEEVLKKYQRLLEKAREEQREIV--------KKHEEDLHILHH--R 1587

Query: 349  LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
            LE + +++ +    T          +L   SPT     K     ++L E+     E  D 
Sbjct: 1588 LELQADSSLNKFKQTAW--------DLMKQSPTPVPTNKHF---IRLAEMEQTVAEQDDS 1636

Query: 409  LLLEKLENKRINKYLD---EI----VKEVE-AKAPILKRQREEYERAQKAVASLSVKLEQ 460
            L    ++ K++++ L+   EI    VKE E  K  + +   +E ++ +  V  L   L+Q
Sbjct: 1637 LSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQ 1696

Query: 461  AMKEIQRLQEDTD---KANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELEEARGNHV 515
            + KE Q L+ +     +AN ++      N   R++ Q+    +Q + L   L E R    
Sbjct: 1697 SQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMT 1756

Query: 516  IRDEE-VSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS 574
               EE + SA     + +  Q +V  R+  EL+ Q + L   L +L     +E  +T+ +
Sbjct: 1757 AAAEERIISATSQKEAHLNVQQIVD-RHTRELKTQVEDLNENLLKL-----KEALKTSKN 1810

Query: 575  KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD 634
            +   L   L     EL++ +K+    ++  + I ++ D  +  + + T     L    L 
Sbjct: 1811 RENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTS---GLQGKPLT 1867

Query: 635  DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQN 694
            D             Q++       V +    +E K     L+ +    K++ A+ E I+ 
Sbjct: 1868 D-----------NKQSLIEELQRKVKKLENQLEGKVEEVDLKPM----KEKNAKEELIRW 1912

Query: 695  EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
            E+ +K Q ++  +R++  +   ++   +K+   L+D      +E  +L    +KL  T  
Sbjct: 1913 EEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQ---RKLKTTGM 1969

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
              +Q++      +R    +  + E++  NL  E ++L +     +  R+S++ +   QN 
Sbjct: 1970 TVDQVLG-----IRALESEKELEELKKRNLDLENDILYM-RAHQALPRDSVVEDLHLQNR 2023

Query: 815  LLT---------------NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE--- 856
             L                +  +I GI      + +Q L  +  KL  E   LK +LE   
Sbjct: 2024 YLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQAN 2083

Query: 857  -------NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLS 909
                   N+V     +   L  +  + +R+L        + K +    +K I  +K+ + 
Sbjct: 2084 KDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTI-PELEKTIGLMKKVVE 2142

Query: 910  NME---VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV-NDLKERLKTSTSNVEQY 965
             ++    Q+   S   T +   + +++ + L ++L + +  + + L    ++ T   E+ 
Sbjct: 2143 KVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI 2202

Query: 966  QAMVTSLEESLNKEKQVTEEVR---KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK 1022
             A    L + L KE    E++R    N+E+  ++      +  K+L   E    +L+   
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGAD 2262

Query: 1023 RRAIESM------EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR---DCQEQAK 1073
             ++ +S+      E +L EL+  ++     + +  Q    A   EQ+  +   D ++Q K
Sbjct: 2263 SKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIK 2322

Query: 1074 I------AVEAQNKYERELML-----HAADVEA------LQAAKEQVSKMASV--RQHLE 1114
            I        E +   +REL +     H  D E       ++A K+Q    +++     L+
Sbjct: 2323 ILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLK 2382

Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLE------------------KQN 1156
            E  +  E+QL   K S  E++  LK+E+ K     E+ +                  K+N
Sbjct: 2383 EKIKDLETQL---KMSDLEKQH-LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKN 2438

Query: 1157 RLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ 1195
             LL ++++KLS+++      GV+    V+ SEE + +E+
Sbjct: 2439 ILLEEKVKKLSEQL------GVELTSPVAASEEFEDEEE 2471



 Score =  115 bits (289), Expect = 4e-25
 Identities = 231/1062 (21%), Positives = 445/1062 (41%), Gaps = 149/1062 (14%)

Query: 47   KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL--KALTEKNKE-LEIAQ 103
            K++ ++    + ++   S+++++NE R       E EKL  +L  K +  K+   L+IA 
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539

Query: 104  DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK---ESNTTKG 160
                 +Q++  + +E L+  +R L +  E   + ++   ED+  L+ +L+   +S+  K 
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKF 1599

Query: 161  ELQLKLDELQASDVSVKYREK--RLEQEKELLHSQNTWLNT---ELKTKTDELLALGREK 215
            + Q   D ++ S   V   +   RL + ++ +  Q+  L++   +LK  + +L     E+
Sbjct: 1600 K-QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL-----ER 1653

Query: 216  GNEILELKCN---------LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
              EI ELK            EN ++EV +++ ++  LK   +  QK  + L ++L+  KE
Sbjct: 1654 QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKE 1713

Query: 267  QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGE-----AN 321
              +         L   +K     K      E +   L+RA+ EL   +  A E     A 
Sbjct: 1714 ANSRAPTTTMRNLVERLKSQLALK------EKQQKALSRALLELRAEMTAAAEERIISAT 1767

Query: 322  KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL------------------ENANDLLSAT 363
               + HL  V+Q  D+  +E+  ++  L + L                  +N NDL +  
Sbjct: 1768 SQKEAHL-NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNEL 1826

Query: 364  KRK----GAILSE-EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK- 417
            ++K      IL E EE+   +       K +  G++   L +       Q L+E+L+ K 
Sbjct: 1827 QKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTD-----NKQSLIEELQRKV 1881

Query: 418  -RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
             ++   L+  V+EV+ K    K  +EE  R ++       K+E    +++  + +     
Sbjct: 1882 KKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEG-KKWQAKIEGIRNKLKEKEGEVFTLT 1940

Query: 477  KQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE----EVSSADISSSSEV 532
            KQ + L+    + + +   L ++++   M +++  G   +  E    E+   ++   +++
Sbjct: 1941 KQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDI 2000

Query: 533  I----SQHLVSYRNIEELQQQNQRLLVALRELGETRERE----------EQETTSSKITE 578
            +     Q L     +E+L  QN+ L   L  L +   ++          E +    +  E
Sbjct: 2001 LYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQE 2060

Query: 579  LQ---LKLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD 634
            LQ   LKL S   EL+ QL ++ +   +L + +   ++M   L  +   V   L      
Sbjct: 2061 LQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG----- 2115

Query: 635  DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKA--ENEKI 692
               +  + +   T         +P +E T  +  K  ++++Q   E  KK      +EK+
Sbjct: 2116 --HVRGSGRSGKT---------IPELEKTIGL-MKKVVEKVQRENEQLKKASGILTSEKM 2163

Query: 693  QN--EQLEKLQEQVTDLRSQ-NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKL 749
             N  ++ EKL+ ++  L++    ++S   +  +K  E +    E  R+E+    +  +KL
Sbjct: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKL 2223

Query: 750  TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLK--KEKEMLKLSEVRLSQQR-ESLL 806
                   E +   MT  L    ++L  AE R   L+    K    +   R+ + + + L 
Sbjct: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELE 2283

Query: 807  AEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT 866
             +   +N  +T+L+     L +  TE +Q+++   E LE +I  LK   E   E    L 
Sbjct: 2284 TDIAKKNQSITDLKQ----LVKEATEREQKVNKYNEDLEQQIKILKHVPEG-AETEQGLK 2338

Query: 867  RNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKG 926
            R L V  L    QLD                 KE A L   +  +E       ++ T   
Sbjct: 2339 RELQVLRL-ANHQLD-----------------KEKAEL---IHQIEANKDQSGAESTIPD 2377

Query: 927  QPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEV 986
                KE + DL +QL+ ++ +   LKE +K     +E +    +  EE  + +    EEV
Sbjct: 2378 ADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDP--SFFEEIEDLKYNYKEEV 2435

Query: 987  RKNI--EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI 1026
            +KNI  E ++K+ +E   QL  +L       +E +D++   +
Sbjct: 2436 KKNILLEEKVKKLSE---QLGVELTSPVAASEEFEDEEESPV 2474



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 104/493 (21%), Positives = 211/493 (42%), Gaps = 56/493 (11%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDG------LKGRHEKFKVESEQQYFEIE 58
            L+   E  EL K    ++N +    A Q    D       L+ R+ + K+ + ++ F  +
Sbjct: 1980 LESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKD 2039

Query: 59   KRLSHSQERLVNET-----RECQSLRLELEKLNNQLK-ALTEKNKELEIAQD--RNIAIQ 110
                 S   + ++      +E Q   L+L   N +LK  L + NK+L   ++  R++   
Sbjct: 2040 TYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEM 2099

Query: 111  SQFTRTKEELEAEKRDLIRTNERLSQ---ELEYLTEDVKRLNEKLKESNTTKGELQLKLD 167
             +F + ++     K   +R + R  +   ELE     +K++ EK++  N      QLK  
Sbjct: 2100 CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE-----QLK-- 2152

Query: 168  ELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL----------KTKTDELLALGREKGN 217
              +AS +    +   +EQE E L ++   L   L          KTK  E +    E+  
Sbjct: 2153 --KASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENER-- 2208

Query: 218  EILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHN 277
                L+  L+ + +   +L    N L+  NE +   +E+   +L+ A+ +   +E     
Sbjct: 2209 ----LRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK 2264

Query: 278  ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
               + I ++ +Y++   + E    +  +++ +L +L+KEA E  + +  +  ++EQ    
Sbjct: 2265 SWKS-IVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKI 2323

Query: 338  MEK--EMLEKIGRLEKELEN---ANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
            ++   E  E    L++EL+    AN  L   K K  ++ + E  A    + A + I    
Sbjct: 2324 LKHVPEGAETEQGLKRELQVLRLANHQLD--KEKAELIHQIE--ANKDQSGAESTIPDAD 2379

Query: 393  MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
                +L     + + QL +  LE + + + + ++ KE+E   P    + E+ +   K   
Sbjct: 2380 ----QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV 2435

Query: 453  SLSVKLEQAMKEI 465
              ++ LE+ +K++
Sbjct: 2436 KKNILLEEKVKKL 2448



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 50/239 (20%), Positives = 114/239 (47%), Gaps = 20/239 (8%)

Query: 1394 NLIQSL-KEDLNKVRTEKETIQKDL-----DAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
            NL+ SL K ++N++++EK+     L         +  QE    + +V+K G        +
Sbjct: 27   NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQ 86

Query: 1448 LKAQQDKV---METSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
            LK +  K+   +E + QS+G         ++ + L+  + Q E + +  + ++E+++K L
Sbjct: 87   LKTKVMKLENELEMAQQSAGG--------RDTRFLRNEICQLEKQLEQKDRELEDMEKEL 138

Query: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKI 1564
             +++     L  +  + ++E S+LR++ +    + EQL Q I + +++         S+ 
Sbjct: 139  EKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRR 198

Query: 1565 AHLAGVKDQLTKENEELKQ---RNGALDQQKDELDVRITALKSQYEGRISRLERELREH 1620
               +  + QL+K+N EL Q       L +  ++++V+   ++   E  +  +E+   E+
Sbjct: 199  GEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEY 257


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  199 bits (506), Expect = 3e-50
 Identities = 315/1522 (20%), Positives = 641/1522 (42%), Gaps = 179/1522 (11%)

Query: 155  SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA--LG 212
            S  T G  + KL+ L   D+ +K+ +K++     +L  +     TEL+ + +EL +  + 
Sbjct: 11   SPATPGTGKSKLETLPKEDL-IKFAKKQM-----MLIQKAKSRCTELEKEIEELRSKPVT 64

Query: 213  REKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
               G+ I  L   L+    E +  E+Q   LK  N  +++ VED +TK+ +A        
Sbjct: 65   EGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDA-------- 116

Query: 273  EKFHNELN-AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
               H EL  +HI      ++  ++  A  ++ +     L K L+EA      + + L   
Sbjct: 117  ---HKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173

Query: 332  EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
              S+D ++K + E+I ++    E    +L   K+  A   E++      T   +  I++ 
Sbjct: 174  NNSEDNVKK-LQEEIEKIRPGFEE--QILYLQKQLDATTDEKK-----ETVTQLQNIIEA 225

Query: 392  GMKLTELYNAYVET-QDQLL----LEKLENKRINKYLDEIVKEVEAKAPILKRQREEY-E 445
                ++ Y   + + Q++LL    + + E K +   ++   KE EA+   L   +E   +
Sbjct: 226  N---SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVK 282

Query: 446  RAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLM 505
            + + +  ++  K E  ++ +++   + ++ N+  S+L ++N  +E  V +  + +   L 
Sbjct: 283  QCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK 342

Query: 506  ELEEARGNHVIRDEEVSSADISSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGET 563
            ELE      +++DE     ++    E+ +QH+    +   E+L+ +   LL+A  E G  
Sbjct: 343  ELESQHS--ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 400

Query: 564  REREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
             E+ + E       +    +E    E++ L++  QHQ ++                    
Sbjct: 401  IEKLKSELAGLN-KQFCYTVEQHNREVQSLKE--QHQKEI-------------------- 437

Query: 624  VAIPLHASSLDDVSLASTPKRPSTS----QTVSTPAPVPVIESTEAIEAKAALKQLQEIF 679
                   S L++  L+ + K   T     Q +         E  EAI    +L+++ EI 
Sbjct: 438  -------SELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL 490

Query: 680  ENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREI 739
            +    E A   KI  E     Q+Q +D+     K+ T         E + + ++G   ++
Sbjct: 491  QTELGESAG--KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV-NRLQGENEKL 547

Query: 740  TSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKE----MLKLSE 795
             S  E   +L  T +  ++        L   +  L   E +  +L +EK+     LK S 
Sbjct: 548  LSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH 607

Query: 796  VRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKK 854
              +    +    E+R   +L    +  Q I   SE E K   L+  +E+   E     +K
Sbjct: 608  EEMDNFHKKCEREER--LILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQK 665

Query: 855  LENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN-----AQKEIATLKQHLS 909
            LE  + Q   L+ + +V   + K   +    L    K+L ++     +QKE   LK+H++
Sbjct: 666  LEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 725

Query: 910  NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV 969
             +E ++     ++    +    E V  L  + +        L   LK   S V       
Sbjct: 726  QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQ--------LYGFLKEMGSEVS------ 771

Query: 970  TSLEESLNKEK-QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK------ 1022
               E+S  K+   V + V +++    +E      Q ++K++E+EKE + LQ++       
Sbjct: 772  ---EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE 828

Query: 1023 -RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNK 1081
             +  +   EQ+   L+K L  +Q+E +EALQ     + N  +  R   +   I VE  ++
Sbjct: 829  LKSLLRDYEQEKVLLRKELEEIQSE-KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQ 887

Query: 1082 YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDE 1141
               +  +H    +      E +  +   ++      +   ++L+  K S  +   +  D 
Sbjct: 888  TCSKSEIHNEKEKCFIKEHENLKPLLEQKE-----LRDRRAELILLKDSLAKSPSVKNDP 942

Query: 1142 VS---KCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILE 1198
            +S   +   + E+LEK+ +   ++I K+    V + KE         L    K  + + E
Sbjct: 943  LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE---------LDSSRKETQTVKE 993

Query: 1199 ILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQ 1258
             L  +R EK+    +   +  + ++  +  + L  E ++  + L+ E+E+       +  
Sbjct: 994  ELESLRSEKD----QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI-- 1047

Query: 1259 HEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKS 1318
             E+L ++     +  ET   +  + E L   ++ +Q+  + LE+ IL +Q A A + ++ 
Sbjct: 1048 -EDLTRQLRNSTLQCET---INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE- 1102

Query: 1319 GMLQAEKKLLEEDVKRWKARNQHL--VSQQKDPDTEEYRKLLSEKEVHTKRIQQLT---E 1373
              L+AEK   E+ +K        L  +  Q   + ++ +K + E E+  K  QQ T    
Sbjct: 1103 --LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM 1160

Query: 1374 EIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQ 1433
            EI   +  +   N  LTN  N I+ L++++   + ++ET+Q+++ +    +Q+  +  T+
Sbjct: 1161 EIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTK 1220

Query: 1434 VKKIGRRYKTQYEELK-AQQDK-VMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK 1491
            +K++  + K +  + K A+ D  +++ S +   +  +Q V V ++Q L E  ++     +
Sbjct: 1221 IKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQ-LAEITSEKHKIHE 1279

Query: 1492 SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
             L++  E  Q+TLS  +     LQE+    ++E + +  + +    +   + +Q  +K +
Sbjct: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ--QKNK 1337

Query: 1552 KTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRIS 1611
               +A                    E E  KQ    L+   D+L +++   ++  +  +S
Sbjct: 1338 SMSQA--------------------ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVS 1377

Query: 1612 RLERELREHQ---ERHLEQRDE 1630
             L+    EH    ERH +   E
Sbjct: 1378 ELQTLQSEHDTLLERHNKMLQE 1399



 Score =  181 bits (460), Expect = 6e-45
 Identities = 329/1625 (20%), Positives = 661/1625 (40%), Gaps = 264/1625 (16%)

Query: 3    AVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS 62
            A LQ+ LE     +L  S Q K +    + +  +  L+   EK +   E+Q   ++K+L 
Sbjct: 150  ANLQKQLEEAMNTQLELSEQLKFQN---NSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206

Query: 63   HSQERLVNETRECQSL-RLELEKLNNQLKALTEKNKELE-IAQDRNIAIQSQFTRTKEEL 120
             + +       + Q++     +     + +L E+  +L+ I Q+    +  Q   + +E 
Sbjct: 207  ATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEH 266

Query: 121  EAEKRDLIRTNERLSQELEYLTEDVKR--------------------------------- 147
            EAE   L    E L ++ E   +++++                                 
Sbjct: 267  EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFV 326

Query: 148  ---LNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTK 204
               +NEK+K    T  EL+ +   L+     +   + +LE + + +  +      +L+ K
Sbjct: 327  EQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFK 386

Query: 205  TDELLALGREKGNEILELKCNLENKKEEVSRLEEQM-NGLKTSNEHLQKHVEDLLTKLKE 263
             +ELL    E+G       C +E  K E++ L +Q    ++  N  +Q   E    ++ E
Sbjct: 387  INELLLAKEEQG-------CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISE 439

Query: 264  AKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLK----EAGE 319
              E   S  EK   +L    ++  L K   ++ + +  E     E L ++++    E GE
Sbjct: 440  LNETFLSDSEK--EKLTLMFEIQGL-KEQCENLQQEKQEAILNYESLREIMEILQTELGE 496

Query: 320  ANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMS 379
            +   I     E E  K Q   ++ E   +L       + LL    R       E+L +  
Sbjct: 497  SAGKISQ---EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG--ENEKLLSQQ 551

Query: 380  PTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK--RINKYLDEIVKEVEAKAPIL 437
                 +   +K   +   +Y   +  +D +L E LE K   + +  D+ + +++     +
Sbjct: 552  ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKE-LEGKINSLTEEKDDFINKLKNSHEEM 610

Query: 438  KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
                ++ ER ++ +  L  K+EQ ++    L++   K N+ +  LE       ++ KD +
Sbjct: 611  DNFHKKCEREERLILELGKKVEQTIQYNSELEQ---KVNELTGGLEE-----TLKEKDQN 662

Query: 498  -QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVA 556
             Q++  L+++++      +  D+EV SA++ S           Y    +L  + ++L   
Sbjct: 663  DQKLEKLMVQMKV-----LSEDKEVLSAEVKS----------LYEENNKLSSEKKQL--- 704

Query: 557  LRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
             R+L     ++E       IT+L+ KL+  + E + L K  +++   V  +  +  +Y  
Sbjct: 705  SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ--VQKLFVKTQLYGF 762

Query: 617  LLSQTTGVAIPLHASSLDDVSLA---STPKRPSTSQTVSTPAPVPVIESTEAI-----EA 668
            L    + V+       + +V  A   S  K       ++      V+E  + I     E+
Sbjct: 763  LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822

Query: 669  KAALKQLQEIFENYKKEKA----ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724
                ++L+ +  +Y++EK     E E+IQ+E+ E LQ  + ++++ N K  T+L+     
Sbjct: 823  VVQCEELKSLLRDYEQEKVLLRKELEEIQSEK-EALQSDLLEMKNANEK--TRLE----- 874

Query: 725  YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
                                 NQ L    ++  Q  +    ++    EK  + E   ENL
Sbjct: 875  ---------------------NQNLLIQVEEVSQTCS--KSEIHNEKEKCFIKE--HENL 909

Query: 785  KK--EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIE 842
            K   E++ L+     L   ++SL      +N  L++++ ++  +E  E E K++   +I 
Sbjct: 910  KPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK-EEKIN 968

Query: 843  KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
            K++      KK+L++  ++  T+   L+  L   K QL        + ++L++ A+    
Sbjct: 969  KIKLVAVKAKKELDSSRKETQTVKEELE-SLRSEKDQLSA------SMRDLIQGAES--- 1018

Query: 903  TLKQHLSNMEVQVASQSSQRTGKGQPSN--KEDVDDLVSQLRQTE---EQVN----DLKE 953
                   N+ ++   QS Q   + + +N  +  ++DL  QLR +    E +N    DL  
Sbjct: 1019 -----YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073

Query: 954  RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEK 1013
            R++T  SN +  +  +  ++ +     +  E  +   E ++KE A    +LE+  ++++K
Sbjct: 1074 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQK 1133

Query: 1014 EKQELQD--DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQ 1071
            EK++LQ    +   ++   QQ + +   ++  +  ++E  Q+    L+N+     D +++
Sbjct: 1134 EKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQK----LTNKNNKIEDLEQE 1189

Query: 1072 AKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASW 1131
             KI  + Q              E LQ   E+++ + S  Q  EE   K +  L++ K   
Sbjct: 1190 IKIQKQKQ--------------ETLQ---EEITSLQSSVQQYEEKNTKIKQLLVKTK--- 1229

Query: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGK 1191
                                     + L D  +  +D ++  ++  ++G L  S  +   
Sbjct: 1230 -------------------------KELADSKQAETDHLI--LQASLKGELEASQQQVEV 1262

Query: 1192 SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQEL---QDSLNAERE- 1247
             + Q+ EI     +  E  +T  E  Q     Y+QRV  L+ E +     Q ++ +E E 
Sbjct: 1263 YKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFES 1322

Query: 1248 -KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI-L 1305
             KV+V      Q  + M + ET           ++E+E LE  + Q++ K++  + ++ +
Sbjct: 1323 YKVRVHNVLKQQKNKSMSQAETEGA--------KQEREHLEMLIDQLKIKLQDSQNNLQI 1374

Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
             + E     SE   +L+   K+L+E V +     + L S Q +         +  K  HT
Sbjct: 1375 NVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN--------MMMKSEHT 1426

Query: 1366 KRIQQLTEEIGRLKAEIARSNASL-TNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI 1424
            + + QLT +   L+         L   ++  +++L++ L+K+  +   ++ +   +    
Sbjct: 1427 QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTR---- 1482

Query: 1425 QEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLN 1484
               V +   +K +  R  T    L        E     + D +    +    Q L++ LN
Sbjct: 1483 -SPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541

Query: 1485 QAETKSK--------SLESQVENLQKTLSE--------KETEARN--LQEQTVQLQSELS 1526
              ETK +        + E  V+ L  T           +ETEA N  L EQ   L+SE+ 
Sbjct: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIR 1601

Query: 1527 RLRQD 1531
            RL ++
Sbjct: 1602 RLERN 1606



 Score =  117 bits (294), Expect = 1e-25
 Identities = 183/866 (21%), Positives = 361/866 (41%), Gaps = 125/866 (14%)

Query: 835  QRLSSQIEKLEHEISHLKKK--LENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKE 892
            Q+  S+  +LE EI  L+ K   E   +    LT  LD  LL+              T++
Sbjct: 42   QKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAE-----------TEQ 90

Query: 893  LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
               + +KE   +KQ + +   ++             ++KE     ++ +++ E   N+L 
Sbjct: 91   QCLSLKKENIKMKQEVEDSVTKMGD-----------AHKELEQSHINYVKEIENLKNELM 139

Query: 953  E-RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEV 1011
              R K S              E+  N +KQ+ E +  N ++ L E  +FQ   E  + ++
Sbjct: 140  AVRSKYS--------------EDKANLQKQLEEAM--NTQLELSEQLKFQNNSEDNVKKL 183

Query: 1012 EKEKQELQDDKRRAIESMEQQLS----ELKKTLSSVQNEVQEALQRASTALSNEQ----Q 1063
            ++E ++++      I  +++QL     E K+T++ +QN ++   Q     +++ Q    Q
Sbjct: 184  QEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQ 243

Query: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQ------------ 1111
             +   QE+ K   E   + E     H A++  L   KE + K     +            
Sbjct: 244  LKAIHQEEVK---ELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE 300

Query: 1112 HLEETTQKAESQLLECKASWEER---ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168
            +L + T  A      C    +E    E+++ ++V       ++LE Q+ +L D++  +++
Sbjct: 301  NLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN 360

Query: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKE---IAETRFEVA-------- 1217
             +   ++   Q   +    E    + +I E+L  + +E++   I + + E+A        
Sbjct: 361  -LKLKLEMDAQHIKDEFFHEREDLEFKINELL--LAKEEQGCVIEKLKSELAGLNKQFCY 417

Query: 1218 -------QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMN 1270
                   +V+SL+ + + E+ E     L DS   E+EK+ +  +     E+     +   
Sbjct: 418  TVEQHNREVQSLKEQHQKEISELNETFLSDS---EKEKLTLMFEIQGLKEQCENLQQEKQ 474

Query: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA--ELSEKSGMLQAEKKLL 1328
              +   + LRE  E L+ +L +   K+ + E + +  Q+A+   EL +K      EK  L
Sbjct: 475  EAILNYESLREIMEILQTELGESAGKISQ-EFESMKQQQASDVHELQQKLRTAFTEKDAL 533

Query: 1329 EEDVKRWKARNQHLVSQQK-DPDTEEYRKLLSEKE-VHTKRIQQLTEEIGRLKAEIARSN 1386
             E V R +  N+ L+SQQ+  P+ E   K L EK  V+   + Q    +  L+ +I   N
Sbjct: 534  LETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI---N 590

Query: 1387 ASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYE 1446
            +      + I  LK        E +   K  + +   I E  K + Q  +     + +  
Sbjct: 591  SLTEEKDDFINKLKNS----HEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646

Query: 1447 ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506
            EL    ++ ++   Q+    ++  V ++ + E KE L+ AE KS   E+   + +K    
Sbjct: 647  ELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS-AEVKSLYEENNKLSSEKKQLS 705

Query: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA------ 1560
            ++ E    Q++ V L+  +++L + LQ    +++ L + +  + E+ +K  V        
Sbjct: 706  RDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL--ENEQVQKLFVKTQLYGFL 763

Query: 1561 -------------KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYE 1607
                         K  +  L  V + L K NEE        D++  EL+  I  L+ +  
Sbjct: 764  KEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESV 823

Query: 1608 GRISRLERELREHQERHLEQRDEPQE 1633
             +   L+  LR++++  +  R E +E
Sbjct: 824  VQCEELKSLLRDYEQEKVLLRKELEE 849



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 98/439 (22%), Positives = 189/439 (43%), Gaps = 85/439 (19%)

Query: 1261 ELMKKTETMNVVMETNKMLREEKER---LEQDLQQMQAKVRKLELDILPLQEANAE---- 1313
            E + K + +    +   ++++ K R   LE++++++++K         P+ E   +    
Sbjct: 23   ETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK---------PVTEGTGDIIKA 73

Query: 1314 LSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE--EYRKLLSEKEV-HTKRIQQ 1370
            L+E+   L  EK   E+     K  N  +  + +D  T+  +  K L +  + + K I+ 
Sbjct: 74   LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIEN 133

Query: 1371 LTEEIGRLKAEIARSNASL---------------------TNNQNLIQSLKEDLNKVRTE 1409
            L  E+  ++++ +   A+L                      N+++ ++ L+E++ K+R  
Sbjct: 134  LKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG 193

Query: 1410 KET----IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYE-----------ELKA-QQD 1453
             E     +QK LDA      EK +T+TQ++ I       Y+           +LKA  Q+
Sbjct: 194  FEEQILYLQKQLDATT---DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE 250

Query: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETL-NQAETKSKSL----ESQVENLQKTLSEKE 1508
            +V E   Q     +E    + ++ ELKE L  Q E   K++    E ++ENL+K  S   
Sbjct: 251  EVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNAN 310

Query: 1509 TEARN----LQEQTVQLQ---SELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAK 1561
             + +     LQE T   Q    ++  L   L++  +Q   L+ ++T       K  + A+
Sbjct: 311  QDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQ 370

Query: 1562 SKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEG-------RISRLE 1614
                    +KD+   E E+L+ +   L   K+E    I  LKS+  G        + +  
Sbjct: 371  H-------IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN 423

Query: 1615 RELREHQERHLEQRDEPQE 1633
            RE++  +E+H ++  E  E
Sbjct: 424  REVQSLKEQHQKEISELNE 442


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  187 bits (476), Expect = 8e-47
 Identities = 243/1181 (20%), Positives = 525/1181 (44%), Gaps = 136/1181 (11%)

Query: 528  SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQ----ETTSSKITELQLKL 583
            ++ +V+ ++  +Y  +   Q    RL   ++ L +   +EE+    E    K+ E QL  
Sbjct: 807  TAMKVLQRNCAAYLKLRNWQWW--RLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAA 864

Query: 584  ESALTELEQLRKSRQ-HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP 642
            E+ LTE+E L+      ++QL + +  + ++                 +  +++    T 
Sbjct: 865  ENRLTEMETLQSQLMAEKLQLQEQLQAETEL----------------CAEAEELRARLTA 908

Query: 643  KRPSTSQTVSTPAPVPVIESTEAI-----EAKAALKQLQEIFENYKKEKAENEKIQNEQ- 696
            K+    + +       V E  E       E K   + +QE+ E  ++E++  +K+Q E+ 
Sbjct: 909  KKQELEE-ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967

Query: 697  -----LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
                 L+KL+E+   L  QN K++       K  ++L+D +  +   +T   E+++ L  
Sbjct: 968  TTEAKLKKLEEEQIILEDQNCKLA-------KEKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020

Query: 752  TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
               K E +I  +        E+L   E + + L+K +  L+     LS Q   L A+   
Sbjct: 1021 LKNKHEAMITDL-------EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073

Query: 812  QNLLLTNLQT-IQGILERSETETKQRLSS--QIEKLEHEISHLKKKLENEVEQRHTLT-- 866
              + L   +  +Q  L R E E  Q+  +  +I +LE +IS L++ LE+E   R+     
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133

Query: 867  -RNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
             R+L  +L   K +L+   +     +EL    ++E+  LK+ L        +Q  +   K
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193

Query: 926  GQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSN----VEQYQAMVTSLEESLNKEKQ 981
                + + V++L  QL QT+    +L++  +T  +       + + ++    +S +K K+
Sbjct: 1194 ----HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249

Query: 982  VTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLS 1041
            V  ++++ ++V+  E    +T+L  K+ +++ E     D+    +   + + S+L K  S
Sbjct: 1250 VEAQLQE-LQVKFNEGERVRTELADKVTKLQVEL----DNVTGLLSQSDSKSSKLTKDFS 1304

Query: 1042 SVQNEVQ---EALQRA-------STALSNEQQARRDCQEQAKIAVEAQNKYERELM-LHA 1090
            ++++++Q   E LQ         ST L   +  +   +EQ +   EA++  E+++  LHA
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364

Query: 1091 ADVEALQAAKEQVSKMAS---VRQHLEETTQKAESQLLECKASWEERERM---LKDEVSK 1144
               +  +  ++ V  + +   V++ L++  +    +  E  A++++ E+    L+ E+  
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424

Query: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
             +    D ++Q+    ++ +K  D+++A  K             E +++E+  + L   R
Sbjct: 1425 LLVDL-DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483

Query: 1205 REKEIAETRFEVAQVESLRYRQRVELLE---------RELQELQDSLNAEREKVQVTAKT 1255
              +E  E +   A++E L  + R E+ +         + + EL+ S  A  ++V+     
Sbjct: 1484 ALEEAMEQK---AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540

Query: 1256 MAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQ--QMQAKVRKLELDILPLQEANAE 1313
            + + E+ ++ TE   + +E N  L+  K + E+DLQ    Q++ +K +L +  ++E  AE
Sbjct: 1541 LEELEDELQATEDAKLRLEVN--LQAMKAQFERDLQGRDEQSEEKKKQL-VRQVREMEAE 1597

Query: 1314 LSEKS---GMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT--EEYRKLLSEKEVHTKRI 1368
            L ++     M  A +K LE D+K  +A   H+ S  K+ D   ++ RKL ++ +   + +
Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEA---HIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654

Query: 1369 QQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK- 1427
                     + A+   +   L + +  +  L+E+L      K   Q++ D    +I    
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS 1714

Query: 1428 ---VKTITQVKKIGRRYKTQYEELKAQQ-------DKVMETSAQSSGDHQEQHVSVQEMQ 1477
                  + + +++  R     EEL+ +Q       D++ + + Q    + + ++     Q
Sbjct: 1715 GKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ 1774

Query: 1478 ELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537
            + +    Q E ++K L+ +++ ++ T+  K       +     L++++++L + L + T 
Sbjct: 1775 KNENARQQLERQNKELKVKLQEMEGTVKSK------YKASITALEAKIAQLEEQLDNETK 1828

Query: 1538 QEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDV 1597
            + +   +Q+   E+K +  ++    +  +    KDQ  K +  LKQ    L++ ++E   
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ- 1887

Query: 1598 RITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKV 1638
            R  A +        +L+REL +  E       E     NK+
Sbjct: 1888 RANASR-------RKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  164 bits (416), Expect = 7e-40
 Identities = 238/1193 (19%), Positives = 510/1193 (42%), Gaps = 133/1193 (11%)

Query: 401  AYVETQDQLLLEKLENKRINKYLD-------EIVKEVEAKAPILKRQREEYERAQKAVAS 453
            A+ + Q QL   K+  +    YL         +  +V+   P+L+  R+E E   K    
Sbjct: 798  AFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVK---PLLQVSRQEEEMMAKEEEL 854

Query: 454  LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
            + V+ +Q   E  RL   T+    QS ++       ++Q+++  Q    L  E EE R  
Sbjct: 855  VKVREKQLAAE-NRL---TEMETLQSQLMAE-----KLQLQEQLQAETELCAEAEELRAR 905

Query: 514  HVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS 573
               + +E+        + V  +        + LQ + +++   ++EL E  E EE     
Sbjct: 906  LTAKKQELEEICHDLEARVEEEE----ERCQHLQAEKKKMQQNIQELEEQLEEEES---- 957

Query: 574  SKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSL 633
                  +L+LE   TE + L+K  + Q+ L D   +     ++L  +       L     
Sbjct: 958  ---ARQKLQLEKVTTEAK-LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013

Query: 634  DDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQ 693
               SLA    +     T          +  E +  +   KQ QE+ +  +K + ++  + 
Sbjct: 1014 KSKSLAKLKNKHEAMIT----------DLEERLRREE--KQRQELEKTRRKLEGDSTDL- 1060

Query: 694  NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE-------MLQDNVEGYRREITSLHERN 746
            ++Q+ +LQ Q+ +L+ Q  K   +L  A  R E       M    +     +I+ L E  
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 747  QKLTATTQKQEQIINTMTQDLRGANEKL--AVAEVRAENLKKEKEMLKLSEVRLSQQRES 804
            +   A+  K E+    + ++L     +L   +    A+   + K   +++ ++ + + E+
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180

Query: 805  LLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHT 864
               E + Q +   + Q ++ + E+ E +TK R+ + +EK +  + + + +L NEV+    
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLE-QTK-RVKANLEKAKQTLENERGELANEVKVLLQ 1238

Query: 865  LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTG 924
               + + +    + QL  E  +  N  E ++    +  T  Q   +    + SQS  ++ 
Sbjct: 1239 GKGDSEHKRKKVEAQLQ-ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297

Query: 925  KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE 984
            K      +D   L SQL+ T+E + +   +  + ++ ++Q +    S  E L +E++   
Sbjct: 1298 K----LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353

Query: 985  EVRKNIEVRLKESAEFQTQLEKK---LMEVEKEKQELQDDKRRAIESMEQQLS---ELKK 1038
             + K I     + A+ + ++E     L   E+ K++LQ D     +  E++++   +L+K
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413

Query: 1039 TLSSVQNEVQEAL-----QRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
            T + +Q E+ + L     QR S     ++Q + D     +  + A+   ER+        
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD-------- 1465

Query: 1094 EALQAAKEQVSKMASVRQHLEETT-QKAESQLLECKASWEERERML-KDEVSKCVCRCED 1151
             A   A+E+ +K  S+ + LEE   QKAE + L  +   E  + M  KD+V K V   E 
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525

Query: 1152 ----LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSE----------EGKSQEQIL 1197
                LE+Q   +  Q+E+L D++ A+    ++  +N+   +          + +S+E+  
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585

Query: 1198 EILRFIRR-EKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER-EKVQVTAKT 1255
            +++R +R  E E+ + R + +   + R +  ++L  ++L+   DS N  R E ++   K 
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAARKKLEMDL--KDLEAHIDSANKNRDEAIKQLRKL 1643

Query: 1256 MAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELS 1315
             AQ ++ M++ +            R  +E +    ++ + K++ +E +++ LQE  A   
Sbjct: 1644 QAQMKDCMRELDDT----------RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693

Query: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT------EEYRKLLSEKEVHTKRIQ 1369
                  Q E+  L +++     +    + +++  +       EE  +     E+   R++
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753

Query: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKD-----------LD 1418
            +   +I ++  ++    +    N+N  Q L+    +++ + + ++             L+
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813

Query: 1419 AKIIDIQEKVKTITQVKKIG----RRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
            AKI  ++E++   T+ ++      RR + + +++  Q D     + Q      +      
Sbjct: 1814 AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST--- 1870

Query: 1475 EMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
             +++LK  L +AE +++   +    LQ+ L +    A  +  +   L+++L R
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923



 Score =  163 bits (413), Expect = 2e-39
 Identities = 256/1252 (20%), Positives = 525/1252 (41%), Gaps = 193/1252 (15%)

Query: 112  QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
            Q +R +EE+ A++ +L++  E+       LTE     ++ + E      +LQL+ ++LQA
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE------KLQLQ-EQLQA 891

Query: 172  SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
                    E  L  E E L ++ T    EL+    +L A   E+      L+   +  ++
Sbjct: 892  --------ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQ 943

Query: 232  EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKS 291
             +  LEEQ+   +++ + LQ        KLK+ +E+Q  +E++       + KL+   K 
Sbjct: 944  NIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ-------NCKLAKEKKL 996

Query: 292  AADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-LE 350
              D     +  LT   E+   L K   +    I D  LE    +++ +++ LEK  R LE
Sbjct: 997  LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD--LEERLRREEKQRQELEKTRRKLE 1054

Query: 351  KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLL 410
             +  + +D ++  + + A L  +         AA+A++ +               Q  + 
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA------------AQKNMA 1102

Query: 411  LEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQE 470
            L+K+  + +   + E+ +++E+       +R    +A+K    L  +LE    E+    E
Sbjct: 1103 LKKI--RELESQISELQEDLES-------ERASRNKAEKQKRDLGEELEALKTEL----E 1149

Query: 471  DTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSS 530
            DT         L+    + E++ K   Q++ +L   LEE    H  + +E+         
Sbjct: 1150 DT---------LDSTAAQQELRSK-REQEVNILKKTLEEEAKTHEAQIQEMR-------- 1191

Query: 531  EVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQ---------L 581
                +H  +   + E  +Q +R+   L +  +T E E  E  +     LQ          
Sbjct: 1192 ---QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248

Query: 582  KLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAS 640
            K+E+ L EL+ +  +  + + +L D + +     ++ L   TG+      S  D  S   
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTK----LQVELDNVTGL-----LSQSDSKSSKL 1299

Query: 641  TPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQN---EQL 697
            T    +    +     +   E+ + +     LKQ+++   +++++  E E+ ++   +Q+
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359

Query: 698  EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
              L  QV D++ +       L+ A +    LQ ++EG       L +R+++  A   K E
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG-------LSQRHEEKVAAYDKLE 1412

Query: 758  QIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT 817
            +    + Q+L      L      A NL+K+++             + LLAE++       
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF-----------DQLLAEEK------- 1454

Query: 818  NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
                    +     E + R  ++  + E +   L + LE  +EQ+  L R          
Sbjct: 1455 -------TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER--------LN 1499

Query: 878  RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
            +Q  TE    +++K+   +  K +  L++    +E QV    +Q            +++L
Sbjct: 1500 KQFRTEMEDLMSSKD---DVGKSVHELEKSKRALEQQVEEMKTQ------------LEEL 1544

Query: 938  VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKE- 996
              +L+ TE    D K RL+ +       QAM    E  L    + +EE +K +  +++E 
Sbjct: 1545 EDELQATE----DAKLRLEVN------LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594

Query: 997  SAEFQTQLEKKLMEVEKEKQELQD--DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054
             AE + + +++ M V   K+   D  D    I+S  +   E  K L  +Q ++++ ++  
Sbjct: 1595 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE- 1653

Query: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
               L + + +R +   QAK   +     E E++    ++ A + AK Q       +Q  +
Sbjct: 1654 ---LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ------AQQERD 1704

Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
            E   +  +   +   + EE+ R L+  +++     E+ +    L++D+++K + ++    
Sbjct: 1705 ELADEIANSSGKGALALEEKRR-LEARIAQLEEELEEEQGNTELINDRLKKANLQI---- 1759

Query: 1175 KEGVQGPLNVSLSEEGKSQ--EQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
             + +   LN+  S   K++   Q LE     R+ KE+     E+      +Y+  +  LE
Sbjct: 1760 -DQINTDLNLERSHAQKNENARQQLE-----RQNKELKVKLQEMEGTVKSKYKASITALE 1813

Query: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ 1292
             ++ +L++ L+ E ++ Q   K + + E+ +K     +V+++ +    +E+   EQ   Q
Sbjct: 1814 AKIAQLEEQLDNETKERQAACKQVRRTEKKLK-----DVLLQVD----DERRNAEQYKDQ 1864

Query: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
                  +L+     L+EA  E    +   +  ++ LE+  +   A N+ + S
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916



 Score =  158 bits (400), Expect = 5e-38
 Identities = 237/1116 (21%), Positives = 478/1116 (42%), Gaps = 175/1116 (15%)

Query: 34   SEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALT 93
            +E + L+ R    K E E+   ++E R+   +ER       CQ L+ E +K+   ++ L 
Sbjct: 897  AEAEELRARLTAKKQELEEICHDLEARVEEEEER-------CQHLQAEKKKMQQNIQELE 949

Query: 94   EKNKELEIAQDRNIAIQSQFTRTK-EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKL 152
            E+ +E E A+ + + ++   T  K ++LE E+  L   N +L++E + L + +      L
Sbjct: 950  EQLEEEESARQK-LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008

Query: 153  KESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALG 212
             E       L    ++ +A    ++ R +R E++++ L      L  +    +D++  L 
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068

Query: 213  REKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
                 +I ELK  L  K+EE+     Q    +   E  QK++   L K++E + Q + ++
Sbjct: 1069 A----QIAELKMQLAKKEEEL-----QAALARVEEEAAQKNM--ALKKIRELESQISELQ 1117

Query: 273  EKFHNELNAHIKLSNLYKSAADDSEAKSNEL--------------TRAVEELHKLLKEAG 318
            E   +E  +  K     +   ++ EA   EL              ++  +E++ L K   
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177

Query: 319  EANKAIQDHLLEVEQSKDQMEKEM---LEKIGRLEKELENANDLLSATKRKGAILSEEEL 375
            E  K  +  + E+ Q   Q  +E+   LE+  R++  LE A   L     +G + +E   
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE--NERGELANE--- 1232

Query: 376  AAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKL-ENKRINKYL-DEIVK---EV 430
                       K++  G   +E     VE Q Q L  K  E +R+   L D++ K   E+
Sbjct: 1233 ----------VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282

Query: 431  EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME 490
            +    +L +   +  +  K  ++L  +L+      + LQE+  +    S+ L+       
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ---ELLQEENRQKLSLSTKLK------- 1332

Query: 491  IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
             QV+D     R  L E EEA+ N + +      A ++   + +   +      EE++++ 
Sbjct: 1333 -QVEDEKNSFREQLEEEEEAKHN-LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390

Query: 551  QRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQ 610
            Q+ L  L     ++  EE+     K+ + + +L+    EL+ L     HQ Q   ++ ++
Sbjct: 1391 QKDLEGL-----SQRHEEKVAAYDKLEKTKTRLQQ---ELDDLLVDLDHQRQSACNLEKK 1442

Query: 611  RDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKA 670
            +  +  LL++   ++    A   ++   A    R   ++ +S    +      EA+E KA
Sbjct: 1443 QKKFDQLLAEEKTIS----AKYAEERDRAEAEAREKETKALSLARAL-----EEAMEQKA 1493

Query: 671  ALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730
             L++L + F    ++   ++    + + +L++    L  Q  ++ TQL       E L+D
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL-------EELED 1546

Query: 731  NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEM 790
             ++        L    Q + A  ++          DL+G +E         ++ +K+K++
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFER----------DLQGRDE---------QSEEKKKQL 1587

Query: 791  LKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISH 850
                 VR  ++ E+ L ++R Q  +                  +++L   ++ LE  I  
Sbjct: 1588 -----VRQVREMEAELEDERKQRSM--------------AVAARKKLEMDLKDLEAHIDS 1628

Query: 851  LKKKLENEVEQRHTLTRNLDVQLLDTKRQLD----TETNLHLNTKE---LLKNAQKEIAT 903
              K  +  ++Q     R L  Q+ D  R+LD    +   +    KE    LK+ + E+  
Sbjct: 1629 ANKNRDEAIKQ----LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684

Query: 904  LKQHLSNME----------VQVASQSSQRTGKGQPS--NKEDVDDLVSQLRQ--TEEQVN 949
            L++ L+  E           ++A + +  +GKG  +   K  ++  ++QL +   EEQ N
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744

Query: 950  D--LKERLKTSTSNVEQYQA---MVTSLEESLNKEKQVTEEVRKNIEVRLKE-----SAE 999
               + +RLK +   ++Q      +  S  +     +Q  E   K ++V+L+E      ++
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804

Query: 1000 FQ---TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQ---- 1052
            ++   T LE K+ ++E++      +++ A + + +   +LK  L  V +E + A Q    
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864

Query: 1053 --RASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
              +AST L   ++   + +E+A+ A  ++ K +REL
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900



 Score =  150 bits (379), Expect = 1e-35
 Identities = 224/1064 (21%), Positives = 453/1064 (42%), Gaps = 140/1064 (13%)

Query: 662  STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLE--------KLQEQV---TDLRSQ 710
            S +  E  A  ++L ++ E  K+  AEN   + E L+        +LQEQ+   T+L ++
Sbjct: 841  SRQEEEMMAKEEELVKVRE--KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 711  NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR-- 768
              ++  +L    +  E +  ++E     +    ER Q L A  +K +Q I  + + L   
Sbjct: 899  AEELRARLTAKKQELEEICHDLEA---RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955

Query: 769  -GANEKLAVAEVRAE-NLKK-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGI 825
              A +KL + +V  E  LKK E+E + L +      +E  L E R      TNL      
Sbjct: 956  ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT-TNLT----- 1009

Query: 826  LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
                E E  + L+    K E  I+ L+++L  E +QR  L +       D+    D    
Sbjct: 1010 ---EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066

Query: 886  LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQ----RTGKGQPSN-KEDVDDLVSQ 940
            L     EL     K+   L+  L+ +E + A ++      R  + Q S  +ED++   + 
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126

Query: 941  LRQTEEQVNDLKERLKTSTSNVEQ-------YQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
              + E+Q  DL E L+   + +E         Q + +  E+ +N  K+  EE  K  E +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186

Query: 994  LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSV---------- 1043
            ++E  +  +Q  ++L E  ++ + ++ +  +A +++E +  EL   +  +          
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246

Query: 1044 QNEVQEALQRASTALSNEQQARRDCQEQ-AKIAVEAQNKYERELMLHAADVEALQAAKEQ 1102
            + +V+  LQ      +  ++ R +  ++  K+ VE  N      +L  +D ++ +  K+ 
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG---LLSQSDSKSSKLTKD- 1302

Query: 1103 VSKMASVRQHLEETTQKAESQLLECKASWEE--------RERMLKDEVSKCVCRCEDLEK 1154
             S + S  Q  +E  Q+   Q L      ++        RE++ ++E +K      +LEK
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK-----HNLEK 1357

Query: 1155 QNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214
            Q   LH Q+  +  K+  SV     G L  +   + K Q+  LE L     EK  A  + 
Sbjct: 1358 QIATLHAQVADMKKKMEDSV-----GCLETAEEVKRKLQKD-LEGLSQRHEEKVAAYDKL 1411

Query: 1215 EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVME 1274
            E  +            L++EL +L   L+ +R+      K   + ++L+ + +T++    
Sbjct: 1412 EKTKTR----------LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA--- 1458

Query: 1275 TNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLL---EED 1331
                  EE++R E + ++ + K   L   +    E  AEL   +   + E + L   ++D
Sbjct: 1459 ---KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515

Query: 1332 VKRWKARNQHLVSQQK---DPDTEEYRKLLSEKEVHTKRIQ----QLTEEIGRLKAEI-- 1382
            V     ++ H + + K   +   EE +  L E E   +  +    +L   +  +KA+   
Sbjct: 1516 V----GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571

Query: 1383 ---ARSNASLTNNQNLIQSLK------EDLNKVRTEKETIQKDLDAKIIDIQEKV----- 1428
                R   S    + L++ ++      ED  K R+     +K L+  + D++  +     
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1631

Query: 1429 ---KTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
               + I Q++K+  + K    EL   +    E  AQ+  + ++      EM +L+E L  
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691

Query: 1486 AETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ 1545
            AE   +  + + + L   ++    +     E+  +L++ +++L ++L++     E +  +
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751

Query: 1546 ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT----A 1601
            + +   +  +       + +H         ++NE  +Q+   L++Q  EL V++      
Sbjct: 1752 LKKANLQIDQINTDLNLERSH--------AQKNENARQQ---LERQNKELKVKLQEMEGT 1800

Query: 1602 LKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645
            +KS+Y+  I+ LE ++ + +E+   +  E Q    +V   ++++
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844



 Score =  110 bits (276), Expect = 1e-23
 Identities = 185/932 (19%), Positives = 391/932 (41%), Gaps = 113/932 (12%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
            +R EL K     + KLE    D   +I  L+ +  + K++  ++  E++  L+  +E   
Sbjct: 1042 QRQELEK----TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE--- 1094

Query: 70   NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
                E     + L+K+      ++E  ++LE  +      + Q     EELEA K +L  
Sbjct: 1095 ----EAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150

Query: 130  T--NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
            T  +    QEL    E    + +K  E      E Q++ +  Q    +V+   ++LEQ K
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ-EMRQKHSQAVEELAEQLEQTK 1209

Query: 188  EL---LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
             +   L      L  E     +E+  L + KG+         E+K+++V    +++    
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDS--------EHKRKKVEAQLQELQVKF 1261

Query: 245  TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
               E ++  + D +TKL+   +    +  +  ++ +   K  +  +S   D++    E  
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321

Query: 305  RAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLEKELENANDLLS 361
            R    L   LK+  +   + ++ L E E++K  +EK++     ++  ++K++E++   L 
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381

Query: 362  ATKRKGAILSEEELAAMS----PTAAAVAKIVKPGMKLTE-----LYNAYVETQDQLLLE 412
              +     L +++L  +S       AA  K+ K   +L +     L +   + Q    LE
Sbjct: 1382 TAEEVKRKL-QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440

Query: 413  KLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV--KLEQAMK------- 463
            K + K+ ++ L E  K + AK    +R R E E  +K   +LS+   LE+AM+       
Sbjct: 1441 K-KQKKFDQLLAE-EKTISAKY-AEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497

Query: 464  -------EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMEL---EEARGN 513
                   E++ L    D   K    LE+  R +E QV+++  Q+  L  EL   E+A+  
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557

Query: 514  HVIR--------DEEVSSADISS---SSEVISQHLVSYRNIEELQQQNQRLLVALRELG- 561
              +         + ++   D  S     +++ Q       +E+ ++Q    + A ++L  
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617

Query: 562  ETREREEQETTSSK--------ITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDM 613
            + ++ E    +++K        + +LQ +++  + EL+  R SR+      + + + ++ 
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE------EILAQAKEN 1671

Query: 614  YRILLS-QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL 672
             + L S +   + +    ++ +     +  +R   +  ++  +    +   E    +A +
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731

Query: 673  KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
             QL+E  E    E+  N ++ N++L+K   Q+  +   NT ++ +   A K     Q   
Sbjct: 1732 AQLEEELE----EEQGNTELINDRLKKANLQIDQI---NTDLNLERSHAQKNENARQ--- 1781

Query: 733  EGYRREITSLHERNQKLTATTQKQEQIINTMTQ-DLRGANEKLAVAEVRAENLKKEKEML 791
                     L  +N++L    Q+ E  + +  +  +     K+A  E + +N  KE++  
Sbjct: 1782 --------QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833

Query: 792  KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHL 851
                 R  ++ + +L +   +     N +  +   +++ T  KQ L  Q+E+ E E    
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDDER---RNAEQYKDQADKASTRLKQ-LKRQLEEAEEEAQRA 1889

Query: 852  ---KKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
               ++KL+ E+E        ++ ++   K +L
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 130/634 (20%), Positives = 265/634 (41%), Gaps = 77/634 (12%)

Query: 6    QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
            Q++L+     KL  S+  KL++   ++ S  + L+   E+ K   E+Q   +  +++  +
Sbjct: 1314 QELLQEENRQKL--SLSTKLKQVEDEKNSFREQLE-EEEEAKHNLEKQIATLHAQVADMK 1370

Query: 66   ERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKR 125
            +++ +     ++      KL   L+ L+++++E   A D+         +TK  L+ E  
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK-------LEKTKTRLQQELD 1423

Query: 126  DLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQ 185
            DL+   +   Q    L +  K+ ++ L E  T                +S KY E+R   
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT----------------ISAKYAEERDRA 1467

Query: 186  EKELLHSQNTWLN-----TELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
            E E    +   L+      E   +  EL  L ++   E+ +L  + ++  + V  LE+  
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK-- 1525

Query: 241  NGLKTSNEHLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAA---DDS 296
                 S   L++ VE++ T+L+E +++ QA+ + K   E+N     +   +      + S
Sbjct: 1526 -----SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580

Query: 297  EAKSNELTRAVEELHKLLKE-------AGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
            E K  +L R V E+   L++       A  A K ++  L ++E   D   K   E I +L
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640

Query: 350  EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409
             K      D +       A  S EE+         +A+  +   KL  +    ++ Q++L
Sbjct: 1641 RKLQAQMKDCMRELDDTRA--SREEI---------LAQAKENEKKLKSMEAEMIQLQEEL 1689

Query: 410  LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469
               +   ++  +  DE+  E+   +       EE  R +  +A L  +LE+     + + 
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749

Query: 470  EDTDKANKQSSVLERD----------NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE 519
            +   KAN Q   +  D          N     Q++  +++++V L E+E    +      
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASI 1809

Query: 520  EVSSADISSSSEVISQHLVSYR-NIEELQQQNQRLLVALRELGETREREEQ-----ETTS 573
                A I+   E +       +   +++++  ++L   L ++ + R   EQ     +  S
Sbjct: 1810 TALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869

Query: 574  SKITELQLKLESALTELEQLRKSRQH-QMQLVDS 606
            +++ +L+ +LE A  E ++   SR+  Q +L D+
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903



 Score = 88.2 bits (217), Expect = 9e-17
 Identities = 99/402 (24%), Positives = 182/402 (45%), Gaps = 51/402 (12%)

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELD--IL 1305
            KV+   +   Q EE+M K E +  V E  K L  E    E +  Q Q    KL+L   + 
Sbjct: 833  KVKPLLQVSRQEEEMMAKEEELVKVRE--KQLAAENRLTEMETLQSQLMAEKLQLQEQLQ 890

Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
               E  AE  E    L A+K+ LEE     +AR +         + E  + L +EK+   
Sbjct: 891  AETELCAEAEELRARLTAKKQELEEICHDLEARVEE--------EEERCQHLQAEKKKMQ 942

Query: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQ 1425
            + IQ+L E++   + E AR               K  L KV TE +   K L+ + I ++
Sbjct: 943  QNIQELEEQLE--EEESARQ--------------KLQLEKVTTEAKL--KKLEEEQIILE 984

Query: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETL-N 1484
            ++   + + KK+              +D++ E +   + + +E+  S+ +++   E +  
Sbjct: 985  DQNCKLAKEKKL-------------LEDRIAEFTTNLT-EEEEKSKSLAKLKNKHEAMIT 1030

Query: 1485 QAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQ 1544
              E + +  E Q + L+KT  + E ++ +L +Q  +LQ++++ L+  L     +EE+L+ 
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQA 1087

Query: 1545 QITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS 1604
             +   EE+  +  +A K KI  L     +L ++ E  +      ++QK +L   + ALK+
Sbjct: 1088 ALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146

Query: 1605 QYEGRI--SRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
            + E  +  +  ++ELR  +E+ +    +  E   K  E Q Q
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188



 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 94/464 (20%), Positives = 195/464 (42%), Gaps = 70/464 (15%)

Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
            ++  +L+  R+E+E+     E+ +V   +      L E E   LQ  L AE+ ++Q    
Sbjct: 833  KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET--LQSQLMAEKLQLQ---- 886

Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL 1314
                 E+L  +TE      E    L  +K+ LE+    ++A+V + E             
Sbjct: 887  -----EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEE------------- 928

Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374
             E+   LQAEKK ++++++         + +Q + +    +KL  EK     ++++L EE
Sbjct: 929  -ERCQHLQAEKKKMQQNIQE--------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979

Query: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQV 1434
                +  +   N  L   + L++    +     TE+E   K L AK+ +  E +  IT +
Sbjct: 980  ----QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL-AKLKNKHEAM--ITDL 1032

Query: 1435 KKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQ-ELKETLNQAETKSKSL 1493
            ++  RR + Q +EL+  + K+        GD  +    + E+Q ++ E   Q   K + L
Sbjct: 1033 EERLRREEKQRQELEKTRRKL-------EGDSTDLSDQIAELQAQIAELKMQLAKKEEEL 1085

Query: 1494 ESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKT 1553
            ++ +  +++  ++K    + ++E    L+S++S L++DL+       +  +Q  +  E+ 
Sbjct: 1086 QAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNKAEKQKRDLGEEL 1141

Query: 1554 RKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRL 1613
                              + L  E E+      A  + + + +  +  LK   E      
Sbjct: 1142 ------------------EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTH 1183

Query: 1614 ERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
            E +++E +++H +  +E  E   +    +  +         ERG
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG 1227



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 80/383 (20%), Positives = 163/383 (42%), Gaps = 39/383 (10%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
            L+  L+ TE  KL   V   L+   A  + ++ G   + E+ K +  +Q  E+E  L   
Sbjct: 1544 LEDELQATEDAKLRLEVN--LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601

Query: 65   QERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQ-FTRTKEELEAE 123
            +++        + L ++L+ L   + +   KN++  I Q R +  Q +   R  ++  A 
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDS-ANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660

Query: 124  KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL------QASDVSVK 177
            + +++   +   ++L+ +  ++ +L E+L  +   K + Q + DEL       +   ++ 
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720

Query: 178  YREKR--------LEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGNEILELK 223
              EKR        LE+E E        +N  LK    ++      L L R    +    +
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780

Query: 224  CNLENKKEEVSRLEEQMNGL-----KTSNEHLQKHVEDLLTKL-KEAKEQQASMEEKFHN 277
              LE + +E+    ++M G      K S   L+  +  L  +L  E KE+QA+ ++    
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840

Query: 278  E---------LNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL 328
            E         ++   + +  YK  AD +  +  +L R +EE  +  + A  + + +Q  L
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900

Query: 329  LEVEQSKDQMEKEMLEKIGRLEK 351
             +  ++ D M +E+     +L +
Sbjct: 1901 EDATETADAMNREVSSLKNKLRR 1923


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  186 bits (473), Expect = 2e-46
 Identities = 388/1957 (19%), Positives = 785/1957 (40%), Gaps = 295/1957 (15%)

Query: 19   KSVQNKLEKFLADQQSEIDGL----KGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRE 74
            K  QNK++K + D   E + L    K +HE   +ESE     +++R S   +       +
Sbjct: 1136 KEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD 1195

Query: 75   CQSLRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTN- 131
             +   + L+  N QL  L    +NKEL++ +      + +    + EL+  + DL  +N 
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQES-----EKEKECLQHELQTIRGDLETSNL 1250

Query: 132  -ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
             +  SQE+  L +      EK           Q     LQ S  +   +   LE+  E+L
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310

Query: 191  HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE----EQMNGLKTS 246
             ++   L TEL     E +   R+   E+ +L   ++   ++   L     E + G +  
Sbjct: 1311 QAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFG 1370

Query: 247  NEHLQKH------------VEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAAD 294
             +  ++H             E L    KE +   A ++EKF +  + H  L + +   + 
Sbjct: 1371 EQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS- 1429

Query: 295  DSEAKSNELTRAVEELH--------KLLKEAGEANKAIQ----DHLLEVEQSKDQMEKEM 342
               +K +EL   V+ L          L    G+  K +Q    + L+    S    +   
Sbjct: 1430 ---SKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSS 1486

Query: 343  LEKIGR---LEKELENANDLLSATKRKGAILS-------------EEELAAMSPTAAAVA 386
            L  +G        LE   D+   +  +GA+ +             +EE      T +A A
Sbjct: 1487 LSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPA 1546

Query: 387  KIVKPGMKLTELYNAYVETQDQLLLEKLENKRI--NKYLDEIVKEVEAKAPILKRQREEY 444
            K V+    L E+Y   +E     L EK+E++ I  NK + E+ + + ++   L   R++Y
Sbjct: 1547 KGVEELESLCEVYRQSLEK----LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY 1602

Query: 445  ----ERAQKAVASLSVKLEQAMK-------------EIQRLQE-------------DTDK 474
                E+ Q+ + S+++++E  +              E+ RLQ              DT+ 
Sbjct: 1603 LSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTED 1662

Query: 475  A------------NKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
            A               S   ER  +    Q+ D   Q + L +++E+      ++     
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQ-QDLNLDIEKITETGAVKPTGEC 1721

Query: 523  SADIS--------------SSSEVISQHLVSYRN--------------------IEELQQ 548
            S + S               SSE IS+   S  N                    ++E   
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781

Query: 549  QNQRLLVALRELGETRER--EEQETTSSKI----TELQLKLESALTELE----QLRKSRQ 598
            +N RLL  + +     E    E +   SK+     +L  K+E+ + ELE    +L+K   
Sbjct: 1782 ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI-ELEKIVGELKKENS 1840

Query: 599  HQMQLVD--SIVRQRDMYRILLSQTTGVAIPLHA--SSLDDVSLASTPKRPSTSQTVSTP 654
               + ++  S   Q  + R+  S+     + +HA  SS +D+         S  +     
Sbjct: 1841 DLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF--- 1897

Query: 655  APVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKI----QNEQLEK----LQEQVTD 706
              + V      I ++ A  + + ++     E  + EK+     NE  +K    L+E+++ 
Sbjct: 1898 --LDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV 1955

Query: 707  LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN-------QKLTATTQKQEQI 759
            + S+  ++  +LD  SK+   L    E  + +   L           Q   A  +++ ++
Sbjct: 1956 VTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL 2015

Query: 760  INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
            + T++ D+    +     + + ++L+K+ + L L++  L  Q   L  E+    LL+   
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE---LLVKES 2072

Query: 820  QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
            +++Q  L  S+ E K  +S  +E    E      +L +  E+ H L R   ++ L  + +
Sbjct: 2073 ESLQARLSESDYE-KLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRG--IEKLRVRIE 2129

Query: 880  LDTETNLHLNTKELLKNAQKEIATLKQHLSNME--VQVASQSSQRTGKGQPSNKEDVDDL 937
             D +  LH+  K  LK  ++E  +LK  + N+E  +Q++ ++ +       ++K +V+ L
Sbjct: 2130 ADEKKQLHIAEK--LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187

Query: 938  VSQLRQTEEQVN-------DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNI 990
             +Q+ +    +         L+   +  T  +++ Q  ++ L++ L+  K + EE ++  
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQA 2246

Query: 991  EVRLKESAEFQTQ-LEKKLMEVEKEKQELQDDK--------------------RRAIESM 1029
            E+++KE ++   + L+ +L E+ +    L  D+                    R +IE +
Sbjct: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306

Query: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQ----EQAKIAVEAQN-KYER 1084
              +L   +K    V  +++E+   A       +   R+ +     Q   A+EA+N K E 
Sbjct: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366

Query: 1085 ELMLHAAD--VEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV 1142
            E +    +   ++L+  +  V  + S +++L    QK + ++ E +      E +L+++ 
Sbjct: 2367 ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426

Query: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI-LR 1201
             + V   E       +L  Q+++L+++V A   +           E  K++EQ L   + 
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKELNERVAALHND----------QEACKAKEQNLSSQVE 2476

Query: 1202 FIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE 1261
             +  EK       + A+   +  +  V  L +E+++ +  L  + E++      +   E+
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ 2536

Query: 1262 LMKKTETMN----VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEK 1317
            L+ K   +     +  E N  LR     LEQ +Q +Q+K   L+  +  LQ +   L  +
Sbjct: 2537 LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENE 2596

Query: 1318 SGMLQAEKKLLEEDVKRWKARNQHLVSQ-----QKDPDTEEYRKLLSEKEVHTKRIQQLT 1372
              + + +K    E V +  A+   L  +     QK  + +E  +L  EK      +Q L 
Sbjct: 2597 LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE--ELSGEKNRLAGELQLLL 2654

Query: 1373 EEIGRLK---AEIARSNASLTNNQNLIQS--------LKEDLNKVRTEKETIQKDLDAKI 1421
            EEI   K    E+   N+ L  + + +          ++E++ + +      +K   A +
Sbjct: 2655 EEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALL 2714

Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKE 1481
            +D  ++ +   +++    +  ++ E L +Q+ ++    +     +     + Q ++ELK+
Sbjct: 2715 LDTNKQYEV--EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772

Query: 1482 T-------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR------L 1528
            T       +NQ + +++  + +++ L K+  + E E   LQ++  QLQ+   +      +
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVM 2832

Query: 1529 RQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGAL 1588
               + + TT+ ++L++ + EK ++  + +     K   L    ++L K  E L+ +   L
Sbjct: 2833 DTKVDELTTEIKELKETLEEKTKEADEYL----DKYCSLLISHEKLEKAKEMLETQVAHL 2888

Query: 1589 DQQKDELDVRITAL-----------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNK 1637
              Q+ + D R + L            S  E R+S  + +    ++R     +  + P+  
Sbjct: 2889 CSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPA 2948

Query: 1638 VPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASI 1697
             PE   + + K   +    GI    D      +P  +     K  A    G K++P   I
Sbjct: 2949 TPESFSKKSKKAVMS----GIHPAEDTEGTEFEPEGLPEVVKKGFADIPTG-KTSP--YI 3001

Query: 1698 RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGP 1734
                T AT T+P        +    +  +   +S  P
Sbjct: 3002 LRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKP 3038



 Score =  179 bits (455), Expect = 2e-44
 Identities = 396/1835 (21%), Positives = 742/1835 (40%), Gaps = 265/1835 (14%)

Query: 26   EKFLADQQSEIDGLK---GRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLEL 82
            + F+A+    I  L+     H+    E+       EK L    +++  E  E Q L+   
Sbjct: 875  QSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSN 934

Query: 83   EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142
              L + LK L   ++ L + +    +I S   R  EEL  E   L   N  L+QE   L 
Sbjct: 935  HLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLI 994

Query: 143  EDVKRLNEKLKESNTTKGEL-----QLKLDELQA--------SDVSVKYREKRLEQEK-E 188
            +  +     + E   +  EL     Q KL  LQ          D+S KY+  + +  K E
Sbjct: 995  QKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054

Query: 189  LLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE----EVSRLEEQMNGLK 244
             L ++ T L    K + ++L     ++  E L      E + +    E+  +++ +    
Sbjct: 1055 CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM 1114

Query: 245  TSNEHLQK-HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
            T N++  K     L  ++   KE+Q  M+++ ++ L  + +L  + K+  +    +S  +
Sbjct: 1115 TDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI 1174

Query: 304  TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
              +V+E      E  + N   Q  L   E S D    ++++    LE  L N    L  +
Sbjct: 1175 RNSVKERE---SERNQCNFKPQMDLEVKEISLDSYNAQLVQ----LEAMLRNKELKLQES 1227

Query: 364  KRKGAILSEEELAAMSPTAAAVAKIVK----PGMKLTEL--YNAYVETQDQLLLEKLENK 417
            +++   L  E          +  + ++     G+K  E+     Y+    +L   + +N 
Sbjct: 1228 EKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNA 1287

Query: 418  RINKYLDEIVKEVEAKAPILK-RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
             +   L   + ++     I +  Q E+YE     V  L+    + +   +++ E+  K  
Sbjct: 1288 HLQCSLQTTMNKLNELEKICEILQAEKYE----LVTELNDSRSECITATRKMAEEVGKLL 1343

Query: 477  KQSSVLERDNRRMEIQ-VKDL---------SQQIRVLLMELEEARG--NHVIRDEEVSS- 523
             +  +L  D+  +  + V+D+         ++Q  V L  L+E+    +  + D+EV   
Sbjct: 1344 NEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMH 1403

Query: 524  --------ADISSSSEVI-SQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS 574
                      + S  +++  QH      + ELQ     L      L  T  R  Q     
Sbjct: 1404 FAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL-STNLRNFQ---GD 1459

Query: 575  KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV--------AI 626
             + E+QL LE  L  +  L  S       + S+      YR LL QT  +        A+
Sbjct: 1460 LVKEMQLGLEEGL--VPSLSSSCVPDSSSLSSL-GDSSFYRALLEQTGDMSLLSNLEGAV 1516

Query: 627  PLHASSLDDVSLASTPKRPST-SQTVSTPAP-VPVIES------------TEAIEAKAAL 672
              +  S+D+V  +S  +   T  +T S PA  V  +ES             E +E++  +
Sbjct: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM 1576

Query: 673  --KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730
              K++QE+ +    E+ E + ++ + L + ++    L S   ++ ++L    K+ E L  
Sbjct: 1577 KNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSL 1636

Query: 731  NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD-LRGANEKLAVAEVRAENLKKEKE 789
             +E  R ++  L   ++ L          +   T+D ++G NE     ++  E+  +  E
Sbjct: 1637 ELEVARLQLQGLDLSSRSL----------LGIDTEDAIQGRNES---CDISKEHTSETTE 1683

Query: 790  MLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE-- 847
                 +V     +++    Q+  NL +  +     +    E   +Q   +  E    +  
Sbjct: 1684 RTPKHDVHQICDKDA----QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739

Query: 848  ------ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL--------NTKEL 893
                  IS L     N +     L    D+  L  + +  +  NL L           E 
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVES 1799

Query: 894  LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
            L N  KE+ + K HL  +++    ++     K     K++  DL  +L        +L +
Sbjct: 1800 LLNEMKELDS-KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858

Query: 954  RLKTS---TSNVEQY--QAMVTSLEESLNKEKQVTEEVRKNIEVRL------KESAEFQT 1002
            R++TS    S++E +  ++    + +++ K     +E   ++E  L      K S E + 
Sbjct: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918

Query: 1003 -QLEKKLMEVEKEKQELQDD---KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
              LE  L  V+ EK  L+ D   K++ I  +E++LS +    + ++ E+ + + + +TAL
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTAL 1977

Query: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV----EALQAAKEQVSKMASVRQHLE 1114
                Q     +E+ +     Q++    + +  A+V    E LQ     VS++   + HL+
Sbjct: 1978 ---DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034

Query: 1115 ETTQKAE--SQLLE-CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVV 1171
            E  Q  E  SQ L   K   E +   L  E    V   E L  Q RL     EKL+    
Sbjct: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL--QARLSESDYEKLNVSKA 2092

Query: 1172 ASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR--REKEIAETRFEVAQVESLRYRQR-- 1227
                   +G   + LS    +QE++ ++ R I   R +  A+ + ++   E L+ R+R  
Sbjct: 2093 LEAALVEKGEFALRLS---STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREN 2149

Query: 1228 ------VELLERELQELQDS-----LNAEREKVQV-TAKTMAQHEELMKKTETMNVVMET 1275
                  VE LERELQ  +++     L+AE  K +V T KT  Q EE+ +  +   + + T
Sbjct: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT--QIEEMARSLKVFELDLVT 2207

Query: 1276 NKMLREEKERLEQDLQQMQAKVRKLELDILPL-------QEANAELSEKS----GMLQAE 1324
               LR EKE L + +Q+ Q ++ +L+  +          ++A  ++ E+S     MLQ +
Sbjct: 2208 ---LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ 2264

Query: 1325 KKLLEEDVKRWKARNQHL--VSQQKDPDTEEYRKL------------------------L 1358
             K L E V       + +    Q  DP  EE  +L                        L
Sbjct: 2265 LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSN-----ASLTNNQNLIQSLK-------EDLNKV 1406
             E E H   ++   E + R + EIAR+N         N++  +++LK       + L  +
Sbjct: 2325 KESEHHADLLKGRVENLER-ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL 2383

Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
              +  TI+ + +    ++Q++ + I++++ I   ++   +E + ++ ++ E S+ +    
Sbjct: 2384 ELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML 2443

Query: 1467 QEQHVSVQE-MQELKETLNQAETKSKSLESQVENLQ---KTLSEKETEARN----LQEQT 1518
            Q Q   + E +  L       + K ++L SQVE L+     L +   EA+N    LQ   
Sbjct: 2444 QTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 2503

Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
              L  E+   +Q L+ +  +  +L+ QI ++E+          SK++ + G + QL KE 
Sbjct: 2504 NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV--------SKLSQVEG-EHQLWKEQ 2554

Query: 1579 E--------ELKQRNGALDQQKDELDVRITALKSQYEGRISRLE----------RELREH 1620
                     EL+Q+   L  +   L   +  L+S Y+   + LE           ++ + 
Sbjct: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM 2614

Query: 1621 QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
              +  E + E  E + K  E Q +++ +    +GE
Sbjct: 2615 TAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649



 Score =  172 bits (437), Expect = 3e-42
 Identities = 321/1469 (21%), Positives = 621/1469 (42%), Gaps = 220/1469 (14%)

Query: 5    LQQVLERTELNKLPKSVQ-NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSH 63
            L+++ E+ E   + K+ +  +LE+ L+ ++ E+D L+   +++  E+EQ   ++      
Sbjct: 1563 LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLR---KQYLSENEQWQQKLTSVTLE 1619

Query: 64   SQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL------EIAQDRNIAIQSQFTRTK 117
             + +L  E ++ + L LELE    QL+ L   ++ L      +  Q RN +       T 
Sbjct: 1620 MESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTS 1679

Query: 118  EELE-AEKRDLIRTNER-----LSQELEYLTED--VKRLNEKLKESNTTKGELQLKLDEL 169
            E  E   K D+ +  ++     L+ ++E +TE   VK   E   E +          D+ 
Sbjct: 1680 ETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739

Query: 170  QASDVSVK---YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
            Q S   +    +         + L +Q    N +L+ K         E  NE L L   +
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK---------ETSNENLRLLHVI 1790

Query: 227  ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLK----------EAKEQQASMEEKF- 275
            E++  +V  L  +M  L  S  HLQ+    L+TK++          E K++ + + EK  
Sbjct: 1791 EDRDRKVESLLNEMKELD-SKLHLQE--VQLMTKIEACIELEKIVGELKKENSDLSEKLE 1847

Query: 276  -----HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKA----IQD 326
                 H EL   ++ S    S   D E  +++ +R  E++   + +  ++ K     +++
Sbjct: 1848 YFSCDHQELLQRVETSEGLNS---DLEMHADKSSR--EDIGDNVAKVNDSWKERFLDVEN 1902

Query: 327  HLLEVEQSKDQMEKEML-----------EKIGRLEKELENANDLLSATKRKGAILSEE-- 373
             L  +   K  +E E L           EK+  LEK+ EN   ++   + + ++++ E  
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLC-LEKDNENKQKVIVCLEEELSVVTSERN 1961

Query: 374  ----ELAAMSPTAAAVAKIV-KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVK 428
                EL  MS    A+ ++  K   K  EL +   E    + + + E K   + L  +  
Sbjct: 1962 QLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSS 2021

Query: 429  EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRR 488
            +V          +E+ +  +K   +LS+   +   +I +L ++ +   K+S  L+     
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081

Query: 489  MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQ- 547
             + +  ++S+ +   L+E    +G   +R        +SS+ E + Q     R IE+L+ 
Sbjct: 2082 SDYEKLNVSKALEAALVE----KGEFALR--------LSSTQEEVHQ---LRRGIEKLRV 2126

Query: 548  --QQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605
              + +++  + + E  + RERE  ++   K+  L+           +L+ S ++Q  ++ 
Sbjct: 2127 RIEADEKKQLHIAEKLKEREREN-DSLKDKVENLE----------RELQMSEENQELVIL 2175

Query: 606  SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665
                 +     L +Q   +A  L    LD V+L S  K   T Q                
Sbjct: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSE-KENLTKQIQ-------------- 2220

Query: 666  IEAKAALKQLQEIFENYKK--EKAENEKIQNEQ-----LEKLQEQVTDLRSQNTKISTQL 718
             E +  L +L ++  ++K   E+ E  +IQ ++     +E LQ Q+ +L      +    
Sbjct: 2221 -EKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 2279

Query: 719  DFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
            +      + L   +E   +   S+ +   +L A  +KQ  ++    Q L+ +     + +
Sbjct: 2280 EIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVL----QQLKESEHHADLLK 2335

Query: 779  VRAENLKKEKEMLKLSEVRLSQQRESLLAEQ-RGQNLLLTNLQTIQGILERSETETKQRL 837
             R ENL++E E+      R +Q+  +L AE  +G+      ++T++  +E   T++ + L
Sbjct: 2336 GRVENLERELEI-----ARTNQEHAALEAENSKGE------VETLKAKIE-GMTQSLRGL 2383

Query: 838  SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNA 897
               +  +  E    K+ L NE+++       L++        +++     L  KE  K  
Sbjct: 2384 ELDVVTIRSE----KENLTNELQKEQERISELEI--------INSSFENILQEKEQEKVQ 2431

Query: 898  QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
             KE ++    +   +++  ++        Q + K    +L SQ+   E +   L + L  
Sbjct: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491

Query: 958  STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQ- 1016
            + +N    Q+ V  L + +   KQ  E+  + I  RLK   + Q QL  KL +VE E Q 
Sbjct: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS-RLKNQIQDQEQLVSKLSQVEGEHQL 2550

Query: 1017 --ELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
              E   + R     +EQ++  L+   +S+Q+ + E LQ +   L NE +  +        
Sbjct: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTL-EVLQSSYKNLENELELTK-------- 2601

Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHL--EETTQKAESQLL--ECKAS 1130
             ++  +  E+   + A + E  +   E   K A +++ L  E+     E QLL  E K+S
Sbjct: 2602 -MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 2660

Query: 1131 WEERERMLKDEVSKCVCRCEDLEKQNRLLH-DQIEKLSDKVVASVKEGVQGPLNVSLSE- 1188
                    KD++ +      +L+K    +H DQ+EK   KV   + E       + L E 
Sbjct: 2661 --------KDQLKELTLENSELKKSLDCMHKDQVEK-EGKVREEIAE-----YQLRLHEA 2706

Query: 1189 EGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVE--LLERELQELQDSLNAER 1246
            E K Q  +L+  +  + E EI   R ++   E     Q++E  LL+   +EL +SL A  
Sbjct: 2707 EKKHQALLLDTNK--QYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATT 2764

Query: 1247 EKVQVTAKTMAQH----EELMKKTET----MNVVMETNKMLREEKERLEQDLQQMQAKVR 1298
            + ++   KT   +     +L K+ E     M +++++ K L EEKE L+++L Q+QA   
Sbjct: 2765 QILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824

Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
            K        Q+    +  K   L  E K L+E ++          +++ D   ++Y  LL
Sbjct: 2825 K--------QKTGTVMDTKVDELTTEIKELKETLEE--------KTKEADEYLDKYCSLL 2868

Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
               E   K  + L  ++  L ++ ++ ++
Sbjct: 2869 ISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897



 Score =  160 bits (405), Expect = 1e-38
 Identities = 327/1585 (20%), Positives = 651/1585 (41%), Gaps = 257/1585 (16%)

Query: 35   EIDGLKGRHEKFKVESEQQYFEI---EKRLSHSQERLVNETRECQSLRLELEKLNNQLKA 91
            +I  L+G+ +K K E +Q+ F++   E  L   ++++ NE  E  +L+ E ++L      
Sbjct: 19   KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL------ 72

Query: 92   LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEK 151
                   +EI +           +TK+++  E +  ++ ++   QE + L    K++ + 
Sbjct: 73   -------MEICES--------LEKTKQKISHELQ--VKESQVNFQEGQ-LNSGKKQIEKL 114

Query: 152  LKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLAL 211
             +E    K EL+      Q++DVS+                     NT  K  T  L   
Sbjct: 115  EQELKRCKSELERSQQAAQSADVSLNP------------------CNTPQKIFTTPLTPS 156

Query: 212  GREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQAS- 270
                G++  +LK     + EE  RLE ++  L+ + +  Q   +  +     A+ Q +S 
Sbjct: 157  QYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ-AKKASQTLPQATMNHRDIARHQASSS 215

Query: 271  ----MEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT--RAVEELHKLLKEAGEANKAI 324
                 +EK  + L+++ + + + +  +    +   E+T  R+  ++ K    +   + + 
Sbjct: 216  VFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSS 275

Query: 325  QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAA 384
              HLL+  ++++Q   E+  KI  LE  L+         + KG +   +EL         
Sbjct: 276  SPHLLDQLKAQNQ---ELRNKINELELRLQG-----HEKEMKGQVNKFQELQ-------- 319

Query: 385  VAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEY 444
              ++ K  ++L E      + +D+L+       R     D+   +  A    LK+  E+ 
Sbjct: 320  -LQLEKAKVELIEKEKVLNKCRDELV-------RTTAQYDQASTKYTALEQKLKKLTEDL 371

Query: 445  ERAQKAVASLSVKLEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVL 503
               ++   S    LEQ +KE ++  QE+  +  +    L+++  +M+ +          L
Sbjct: 372  SCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR----------L 421

Query: 504  LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGET 563
              EL++A+  H +   E                      +++L    Q+L   L E  + 
Sbjct: 422  TQELQQAKNMHNVLQAE----------------------LDKLTSVKQQLENNLEEFKQK 459

Query: 564  REREEQETTSSKITELQLK--LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQT 621
              R EQ   +S+I E +L+  +E    E   L+   + + + V  +  +    +  L+Q+
Sbjct: 460  LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQS 519

Query: 622  TGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFEN 681
                           + A   K  +TSQ                   +  L+ LQE    
Sbjct: 520  Q--------------NFAEEMKAKNTSQ-------------------ETMLRDLQE---- 542

Query: 682  YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITS 741
             K  + EN    +  LEKL+  V DL  Q       L       E L D +    +E  +
Sbjct: 543  -KINQQEN----SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597

Query: 742  LHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV-AEVRAENLKKE----KEMLKLSEV 796
            L     +L     ++ +   T+    +  NEKL    E   ENL+ +    +  LK  ++
Sbjct: 598  LLSA-LELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656

Query: 797  RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE 856
            +  +  E +   +  +  L   ++ +  +L+    E + +  + +E L+ +     +K +
Sbjct: 657  KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME-LQQKAEFSDQKHQ 715

Query: 857  NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVA 916
             E+E     T  L  Q+ D + +L   +N  ++     ++   E  +L+  L + +  + 
Sbjct: 716  KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775

Query: 917  S----QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSL 972
            +    Q S      QP+      +++ +      + ++ +     S  N    Q  V SL
Sbjct: 776  TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835

Query: 973  EESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQ 1032
            E SL  +KQ+  +++K  E    E  + + ++E+ LM+ E+  Q    +  + I  +++ 
Sbjct: 836  EFSLESQKQMNSDLQKQCE----ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED 891

Query: 1033 LSE----LKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELML 1088
             S     + +TLS+++N+ +E LQ  +  +  EQ   ++ ++   +  ++     +EL L
Sbjct: 892  TSAHQNVVAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLEDSL----KELQL 946

Query: 1089 HAADVEALQAAKEQVSKMASV-RQHLEETTQKAESQLLECKASWEERERML--------- 1138
             +   E L   K+++S + S+ ++ +EE TQ+    L E  AS  + +  L         
Sbjct: 947  LS---ETLSLEKKEMSSIISLNKREIEELTQE-NGTLKEINASLNQEKMNLIQKSESFAN 1002

Query: 1139 -KDEVSKCVCRCEDLEKQNRLL--------HDQIEKLSDKVVASVKEG--VQGPLN--VS 1185
              DE  K +    D  KQ +L+         +  E LS K  A+ ++   ++  LN   S
Sbjct: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062

Query: 1186 LSEEGKSQ-EQILEILRFIRREKE------IAETRFE--VAQVESLRYRQRVELLERE-- 1234
            L E  K++ EQ+ E   F +  +E       AE R +  + ++E+++   R E+ + +  
Sbjct: 1063 LCENRKNELEQLKE--AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120

Query: 1235 -------LQELQDSLNAEREKVQVTAKTMAQ-HEELMK----KTETMNVVME--TNKMLR 1280
                   L++   +L  E+ K+Q     + Q +E+LMK    K E  N+  E   N +  
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180

Query: 1281 EEKERLEQDLQ-QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
             E ER + + + QM  +V+++ LD       NA+L +   ML+ ++  L+E  K  +   
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLD-----SYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235

Query: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
              L + + D +T   + + S++    K  +   EE  +  +     + S  +N +L  SL
Sbjct: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE--KYISGPHELSTSQNDNAHLQCSL 1293

Query: 1400 KEDLNKVRTEKETIQKDLDAKIIDI-----QEKVKTITQVKKIGRRYKTQYEELKAQQDK 1454
            +  +NK+  E E I + L A+  ++       + + IT  +K+         E+K   D 
Sbjct: 1294 QTTMNKL-NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352

Query: 1455 --------VMETSAQSSGDH-QEQH-VSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
                    V +      G+   EQH VS+  + E   +        K ++     LQ+  
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE-SNSYEHLTLSDKEVQMHFAELQEKF 1411

Query: 1505 SEKETEARNLQEQTVQLQSELSRLR 1529
               ++E + L +Q  Q+ S++S L+
Sbjct: 1412 LSLQSEHKILHDQHCQMSSKMSELQ 1436



 Score =  155 bits (392), Expect = 4e-37
 Identities = 379/1823 (20%), Positives = 730/1823 (40%), Gaps = 349/1823 (19%)

Query: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
            R ++N+L   +Q   EK +  Q ++   L+ + EK KVE      E EK L+  ++ LV 
Sbjct: 291  RNKINELELRLQGH-EKEMKGQVNKFQELQLQLEKAKVE----LIEKEKVLNKCRDELVR 345

Query: 71   ETRECQSLRLELEKLNNQLKALTE----KNKELEIAQ--------DRNIAIQSQFTRTKE 118
             T +      +   L  +LK LTE    + +  E A+        ++    Q + +R + 
Sbjct: 346  TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405

Query: 119  ELEAEKRDLIRTNERLSQELEY---------------------LTEDVKRLNEKLKESNT 157
              +   ++ I+   RL+QEL+                      L  +++   +KL  +  
Sbjct: 406  SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465

Query: 158  TKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELK--------------- 202
                 Q+K +EL+ S   +K     L+   E    +   L  ELK               
Sbjct: 466  AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE 525

Query: 203  -----TKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL 257
                 T  + +L   +EK N+  E    LE  K  V+ LE+Q +  +   +  + H+E L
Sbjct: 526  MKAKNTSQETMLRDLQEKINQ-QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584

Query: 258  LTKL-KEAKEQQA-----SMEEKFHNELNAHIKLSNLYKSAAD----DSEAKSNELTRAV 307
              KL K  KE +A      +++K + EL     L + +KS  +      E++   L   +
Sbjct: 585  NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644

Query: 308  EELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367
              L   LK      + I+ H         +M++E       L  E+ N +++L +   K 
Sbjct: 645  NHLETCLK-----TQQIKSHEYNERVRTLEMDRE------NLSVEIRNLHNVLDS---KS 690

Query: 368  AILSEEELAAMSPTAAA-------VAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
              +  ++LA M     A         +I    +K ++L     + + +L L   E    +
Sbjct: 691  VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750

Query: 421  KYLDEIVKEVEAKAPILKRQ------REEYERA----------QKAVASLSVKLEQAMKE 464
            +   ++  E E+   +LK +       E+++R+            + A++  +      E
Sbjct: 751  RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810

Query: 465  IQRLQEDTDKANKQSSVLERDNRRMEIQV---KDLSQQIRVLLMELEEARG---NHVIRD 518
                + + D++ K S++L+     +E  +   K ++  ++    EL + +G    ++++ 
Sbjct: 811  RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870

Query: 519  EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITE 578
            E++  + ++ +S+ IS+       ++E    +Q ++       E +E+E Q         
Sbjct: 871  EQMHQSFVAETSQRISK-------LQEDTSAHQNVVAETLSALENKEKELQ--------L 915

Query: 579  LQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL 638
            L  K+E+   E+++L+KS      L DS+   +     LLS+T      L     +  S+
Sbjct: 916  LNDKVETEQAEIQELKKSNH---LLEDSLKELQ-----LLSET------LSLEKKEMSSI 961

Query: 639  ASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLE 698
             S  KR     T        +  S    + K  L Q  E F NY  E+           E
Sbjct: 962  ISLNKREIEELTQENGTLKEINASLN--QEKMNLIQKSESFANYIDER-----------E 1008

Query: 699  KLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQ 758
            K   +++D   Q   I  Q      R E   +  E   ++  +  E+N KL       E 
Sbjct: 1009 KSISELSDQYKQEKLILLQ------RCEETGNAYEDLSQKYKAAQEKNSKL-------EC 1055

Query: 759  IINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQ--RESLLAEQRGQNLLL 816
            ++N  T                 EN K E E LK +  +  Q+   +   AE+R QNL+L
Sbjct: 1056 LLNECTS--------------LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML 1101

Query: 817  TNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK---KLENEVEQRHTLTRNLDVQL 873
              L+T+Q  L    T+ +    S+   L+ EI  LK+   K++ EV         L +++
Sbjct: 1102 -ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL-MKV 1159

Query: 874  LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTG----KGQPS 929
            + TK +     +  +      + +++     K  + ++EV+  S  S        +    
Sbjct: 1160 MKTKHECQNLESEPIRNSVKERESERNQCNFKPQM-DLEVKEISLDSYNAQLVQLEAMLR 1218

Query: 930  NKEDVDDLVSQLRQTEEQVNDLKERLKT-----STSNVEQYQAM-VTSLEE--------- 974
            NKE       +L+++E++   L+  L+T      TSN++  Q+  ++ L++         
Sbjct: 1219 NKE------LKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKY 1272

Query: 975  -SLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK--KLMEVEKEK--QELQDDKRRAIESM 1029
             S   E   ++    +++  L+ +     +LEK  ++++ EK +   EL D +   I + 
Sbjct: 1273 ISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITAT 1332

Query: 1030 EQQLSELKKTLSSVQ--NEVQEAL--QRASTALSNEQQARRDCQEQAKIA-VEAQNKYE- 1083
             +   E+ K L+ V+  N+    L  +        E   + + Q    +A ++  N YE 
Sbjct: 1333 RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392

Query: 1084 -----RELMLHAADVE----ALQAAK--------EQVSKMASVRQHLEETTQKAESQLLE 1126
                 +E+ +H A+++    +LQ+          +  SKM+ ++ +++  + KAE+ +L 
Sbjct: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD--SLKAENLVLS 1450

Query: 1127 C-----------KASWEERERMLKDEVSKCVCRCEDLEK--QNRLLHDQIEKLSDKVVAS 1173
                        +      E ++    S CV     L     +      +E+  D  + S
Sbjct: 1451 TNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS 1510

Query: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESL--RYRQRVELL 1231
              EG       S+ E   S    L+     R+E   A  +  V ++ESL   YRQ +E L
Sbjct: 1511 NLEGAVSANQCSVDEVFCSS---LQEENLTRKETPSAPAK-GVEELESLCEVYRQSLEKL 1566

Query: 1232 E-----------RELQELQDSLNAEREKVQVTAKT-MAQHEELMKKTETMNVVMETNKML 1279
            E           +E+QEL+  L++ER+++    K  ++++E+  +K  ++ + ME +K+ 
Sbjct: 1567 EEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEME-SKLA 1625

Query: 1280 REEK--ERLEQDLQQMQAKVRKLELDILPLQEANAE--LSEKSGMLQAEKKLLEEDVKRW 1335
             E+K  E+L  +L+  + +++ L+L    L   + E  +  ++      K+   E  +R 
Sbjct: 1626 AEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTER- 1684

Query: 1336 KARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLK---------------- 1379
                +H V Q  D D ++   L  EK   T  ++   E  G                   
Sbjct: 1685 --TPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS 1742

Query: 1380 ----AEIARSNASL----------------------TNNQNL-IQSLKEDLNKVRTEKET 1412
                +E++ S  +                       T+N+NL +  + ED ++       
Sbjct: 1743 SECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN 1802

Query: 1413 IQKDLDAKI----IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
              K+LD+K+    + +  K++   +++KI         ELK +   + E     S DHQE
Sbjct: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKI-------VGELKKENSDLSEKLEYFSCDHQE 1855

Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKT-------LSEKETEARNLQEQTVQL 1521
                V+  + L   L     KS S E   +N+ K          + E E   ++ +   +
Sbjct: 1856 LLQRVETSEGLNSDLEMHADKS-SREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI 1914

Query: 1522 QSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEEL 1581
            + E   L  DL+    Q E+L   + +  E  +K IV  + +++ +   ++QL  E + +
Sbjct: 1915 EHEALYLEADLE--VVQTEKL--CLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970

Query: 1582 KQRNGALDQQKDELDVRITALKS 1604
             ++  ALDQ  +++  +   L+S
Sbjct: 1971 SKKTTALDQLSEKMKEKTQELES 1993



 Score =  150 bits (380), Expect = 1e-35
 Identities = 284/1397 (20%), Positives = 565/1397 (40%), Gaps = 196/1397 (14%)

Query: 331  VEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV----- 385
            +E+ K+ +    L+KI  LE +L    D L   K++     +   AA+      V     
Sbjct: 5    LEEWKEGLPTRALQKIQELEGQL----DKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60

Query: 386  --AKIVKPGMKLTELYNAYVETQDQLLLE-KLENKRIN---KYLDEIVKEVEAKAPILKR 439
                + +   +L E+  +  +T+ ++  E +++  ++N     L+   K++E     LKR
Sbjct: 61   EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120

Query: 440  QREEYERAQKAVASLSVKLE-----QAMKEIQRLQEDTDKANKQSSVLERDN------RR 488
             + E ER+Q+A  S  V L      Q +             +K   + E+ N      +R
Sbjct: 121  CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180

Query: 489  MEIQVKDLSQQIRVLLMELEEARGNH-VIRDEEVSSADISSSSEVISQHLVS-------- 539
            +E +VK L  Q +     L +A  NH  I   + SS+  S   E    HL S        
Sbjct: 181  LEAEVKAL--QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIR 238

Query: 540  -------YRNIEELQQQNQRLLVALRELGET------------REREEQETTSSKITELQ 580
                   +   +E+      L +  R+   +            + + + +   +KI EL+
Sbjct: 239  RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298

Query: 581  LKLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639
            L+L+    E++ Q+ K ++ Q+QL  + V   +  ++L             +   D  + 
Sbjct: 299  LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-------------NKCRDELVR 345

Query: 640  STPK--RPSTSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNE 695
            +T +  + ST  T        + E  S +   A++A   L++  +  +KE  E    Q  
Sbjct: 346  TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405

Query: 696  QLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK 755
              + L ++   +++   +++ +L  A   + +LQ  ++              KLT+  Q+
Sbjct: 406  SFQTLDQECIQMKA---RLTQELQQAKNMHNVLQAELD--------------KLTSVKQQ 448

Query: 756  QEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLL 815
             E  +    Q L  A +    ++++   L++  E +K     L    E    E       
Sbjct: 449  LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508

Query: 816  LTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD 875
            L N++      +    E K + +SQ    E  +  L++K+ N+ E   TL + L + + D
Sbjct: 509  LKNIKQCLNQSQNFAEEMKAKNTSQ----ETMLRDLQEKI-NQQENSLTLEK-LKLAVAD 562

Query: 876  TKRQLDTETNL---------HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRT--G 924
             ++Q D   +L          LN K  L   +KE   L   L   + +      ++T   
Sbjct: 563  LEKQRDCSQDLLKKREHHIEQLNDK--LSKTEKESKALLSALELKKKEYEELKEEKTLFS 620

Query: 925  KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE 984
              +  N++ +  + S+    + ++N L+  LKT      +Y   V +LE      + ++ 
Sbjct: 621  CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD---RENLSV 677

Query: 985  EVRKNIEVRLKESAEFQTQLEKKLMEVE-KEKQELQDDK-RRAIESM-------EQQLSE 1035
            E+R    V   +S E +TQ   KL  +E ++K E  D K ++ IE+M         Q+ +
Sbjct: 678  EIRNLHNVLDSKSVEVETQ---KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734

Query: 1036 LKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELM-------L 1088
            L+  L  + NE+ +   R    L  E ++ RD  +    ++     ++R L+       +
Sbjct: 735  LEHKLQLLSNEIMDK-DRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793

Query: 1089 HAADVEALQAAKEQVSKMASVRQHLEETTQKA---ESQLLECKASWEERERMLKDEVSKC 1145
            H +    +       S+ +  R   +++ + +   ++++   + S E +++M  D     
Sbjct: 794  HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK-- 851

Query: 1146 VCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ-----ILEIL 1200
              +CE+L +    + + + K      + V E  Q    +S  +E  S  Q      L  L
Sbjct: 852  --QCEELVQIKGEIEENLMKAEQMHQSFVAETSQ---RISKLQEDTSAHQNVVAETLSAL 906

Query: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ-DSLNAEREKVQVTAKTMAQH 1259
                +E ++   + E  Q E    ++   LLE  L+ELQ  S     EK ++++      
Sbjct: 907  ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966

Query: 1260 EELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE---------- 1309
             E+ + T+    + E N  L +EK  L Q  +     + + E  I  L +          
Sbjct: 967  REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026

Query: 1310 --------ANAELSEKSGMLQAEKK----LLEEDVKRWKARNQHLVSQQKDPDTEEYRKL 1357
                    A  +LS+K    Q +      LL E     + R   L  Q K+   +E+++ 
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL-EQLKEAFAKEHQEF 1085

Query: 1358 LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS----LKEDLNKVRTEKETI 1413
            L++     +R Q L  E+  ++  +    + +T+NQN  +S    LK+++  ++ E+  +
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQAL---RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM 1142

Query: 1414 QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
            QK+++  + + ++ +K +          KT++E    + + +  +  +   +  + +   
Sbjct: 1143 QKEVNDLLQENEQLMKVM----------KTKHECQNLESEPIRNSVKERESERNQCNFKP 1192

Query: 1474 QEMQELKE-TLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDL 1532
            Q   E+KE +L+    +   LE+ + N +  L E E E   LQ +   ++ +L     +L
Sbjct: 1193 QMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE--TSNL 1250

Query: 1533 QDRTTQE-EQLRQQITEKEEKTRKA---IVAAKSKIAHLAGVKDQLTKENEELKQRNGAL 1588
            QD  +QE   L+    + EEK       +  +++  AHL         +  EL++    L
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310

Query: 1589 DQQKDELDVRITALKSQ 1605
              +K EL   +   +S+
Sbjct: 1311 QAEKYELVTELNDSRSE 1327



 Score =  149 bits (375), Expect = 4e-35
 Identities = 333/1682 (19%), Positives = 661/1682 (39%), Gaps = 279/1682 (16%)

Query: 36   IDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK 95
            +D LK ++++ +     +  E+E RL   ++ +  +  + Q L+L+LEK   +L    EK
Sbjct: 280  LDQLKAQNQELR----NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL---IEK 332

Query: 96   NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKES 155
             K L   +D  +   +Q+ +   +  A           L Q+L+ LTED+    +  + +
Sbjct: 333  EKVLNKCRDELVRTTAQYDQASTKYTA-----------LEQKLKKLTEDLSCQRQNAESA 381

Query: 156  NTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREK 215
              +               +  K +EK  E ++EL   Q ++     +T   E + +    
Sbjct: 382  RCS---------------LEQKIKEKEKEFQEELSRQQRSF-----QTLDQECIQMKARL 421

Query: 216  GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQ-QASM--E 272
              E+ + K N+ N       L+ +++ L +  + L+ ++E+   KL  A++  QAS   E
Sbjct: 422  TQELQQAK-NMHNV------LQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474

Query: 273  EKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
             +    +    K +NL KS    SE K+ E+     EL K +K+    ++   + +    
Sbjct: 475  NELRRSMEEMKKENNLLKS---HSEQKAREVCHLEAEL-KNIKQCLNQSQNFAEEMKAKN 530

Query: 333  QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
             S++ M +++ EKI + E  L       +  K K A+   E+    S             
Sbjct: 531  TSQETMLRDLQEKINQQENSL-------TLEKLKLAVADLEKQRDCS------------- 570

Query: 393  MKLTELYNAYVETQDQLLLEKLEN--KRINKYLDEIVKEVEAKAPILKRQREEYERAQKA 450
                           Q LL+K E+  +++N  L +  KE +A    L+ +++EYE  ++ 
Sbjct: 571  ---------------QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615

Query: 451  VASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE-- 508
                S    +  K + +++ + +    + + LE   +  +I+  + ++++R L M+ E  
Sbjct: 616  KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675

Query: 509  --EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER 566
              E R  H + D        S S EV +Q L       ELQQ+         E  + + +
Sbjct: 676  SVEIRNLHNVLD--------SKSVEVETQKLA----YMELQQK--------AEFSDQKHQ 715

Query: 567  EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRD-MYRILLSQTTGVA 625
            +E E    K ++L  ++E             +H++QL+ + +  +D  Y+ L ++   + 
Sbjct: 716  KEIENMCLKTSQLTGQVEDL-----------EHKLQLLSNEIMDKDRCYQDLHAEYESLR 764

Query: 626  IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685
              L +    D SL  T +    S       P         I  + ++   +        +
Sbjct: 765  DLLKSK---DASLV-TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820

Query: 686  KAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER 745
              +N  I   +++ L+  +   +  N+ +  Q +      E++Q   E     +    + 
Sbjct: 821  SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE------ELVQIKGE-IEENLMKAEQM 873

Query: 746  NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESL 805
            +Q   A T    Q I+ + +D   +  +  VAE  +    KEKE+  L++ ++  ++  +
Sbjct: 874  HQSFVAET---SQRISKLQEDT--SAHQNVVAETLSALENKEKELQLLND-KVETEQAEI 927

Query: 806  LAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTL 865
               ++  +LL  +L+ +Q + E    E K+  S         I  L K+   E+ Q +  
Sbjct: 928  QELKKSNHLLEDSLKELQLLSETLSLEKKEMSS---------IISLNKREIEELTQENGT 978

Query: 866  TRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
             + ++  L   K  L  ++    N    +   +K I+ L       E  +  Q  + TG 
Sbjct: 979  LKEINASLNQEKMNLIQKSESFAN---YIDEREKSISELSDQY-KQEKLILLQRCEETGN 1034

Query: 926  GQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
                     +DL  + +  +E+ + L+  L   TS  E  +  +  L+E+  KE Q   E
Sbjct: 1035 A-------YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ---E 1084

Query: 986  VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQN 1045
                +    + +     +LE     +  E  + Q++ +     ++Q++  LK+  + +Q 
Sbjct: 1085 FLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK 1144

Query: 1046 EVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSK 1105
            EV + LQ  +  L    + + +CQ      +    K ERE   +  + +     + +   
Sbjct: 1145 EVNDLLQE-NEQLMKVMKTKHECQNLESEPIRNSVK-ERESERNQCNFKPQMDLEVKEIS 1202

Query: 1106 MASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQN--RLLHDQI 1163
            + S    L +      ++ L+ + S +E+E  L+ E+        DLE  N   +   +I
Sbjct: 1203 LDSYNAQLVQLEAMLRNKELKLQESEKEKE-CLQHELQTI---RGDLETSNLQDMQSQEI 1258

Query: 1164 EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLR 1223
              L D  + + ++ + GP  +S S+   +  Q             +  T  ++ ++E + 
Sbjct: 1259 SGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC-----------SLQTTMNKLNELEKI- 1306

Query: 1224 YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK 1283
                 E+L+ E  EL   LN  R +     + MA  EE+ K    + ++ + + +L  E 
Sbjct: 1307 ----CEILQAEKYELVTELNDSRSECITATRKMA--EEVGKLLNEVKILNDDSGLLHGE- 1359

Query: 1284 ERLEQDLQQMQAKVRKLE---LDILPLQEAN----------------AELSEKSGMLQAE 1324
              L +D+   +   +  E   + + PL E+N                AEL EK   LQ+E
Sbjct: 1360 --LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE 1417

Query: 1325 KKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
             K+L +         QH     K  + + Y                    +  LKAE   
Sbjct: 1418 HKILHD---------QHCQMSSKMSELQTY--------------------VDSLKAENLV 1448

Query: 1385 SNASLTNNQ-NLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT 1443
             + +L N Q +L++ ++  L      +E +   L +  +     + ++         Y+ 
Sbjct: 1449 LSTNLRNFQGDLVKEMQLGL------EEGLVPSLSSSCVPDSSSLSSLGD----SSFYRA 1498

Query: 1444 QYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKS------KSLESQV 1497
              E+            A S+       V    +QE  E L + ET S      + LES  
Sbjct: 1499 LLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQE--ENLTRKETPSAPAKGVEELESLC 1556

Query: 1498 ENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAI 1557
            E  +++L + E     ++ Q +    E+  L Q L     + + LR+Q   + E+ ++ +
Sbjct: 1557 EVYRQSLEKLE---EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKL 1613

Query: 1558 VAA----KSKIAHLAGVKDQLTKENEELKQRNGALD---------QQKDELDVRITALKS 1604
             +     +SK+A      +QL+ E E  + +   LD           +D +  R  +   
Sbjct: 1614 TSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDI 1673

Query: 1605 QYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTT-PASGERGIASTSD 1663
              E      ER   +H    +  +D  Q+ +  + +      +K T   SGE+   +  +
Sbjct: 1674 SKEHTSETTER-TPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYE 1732

Query: 1664 PP 1665
            PP
Sbjct: 1733 PP 1734



 Score =  139 bits (351), Expect = 3e-32
 Identities = 207/1038 (19%), Positives = 439/1038 (42%), Gaps = 137/1038 (13%)

Query: 695  EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
            +++++L+ Q+  L+ +  +   QLD      +  +  VE  + E T+L   NQ+L    +
Sbjct: 18   QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
              E+    ++ +L+    ++   E +  + KK+ E L+    R   + E      +  ++
Sbjct: 78   SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137

Query: 815  LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
             L    T Q I     T ++    S+ E        LK+K   EVE+R  L    +V+ L
Sbjct: 138  SLNPCNTPQKIFTTPLTPSQYYSGSKYE-------DLKEKYNKEVEERKRL--EAEVKAL 188

Query: 875  DTKRQLDTETNLHLNTKELLKN-AQKEIATLKQHLSNMEVQVASQSSQRT------GKGQ 927
              K+   T     +N +++ ++ A   + + +Q  +   +   S +SQRT          
Sbjct: 189  QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHL---SSNSQRTPIRRDFSASY 245

Query: 928  PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR 987
             S +++V    S L+  +   N       +S   ++Q +A    L   +N+ +   +   
Sbjct: 246  FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305

Query: 988  KNIEVRLKESAEFQTQLEKKLME-VEKEK------QEL------QDDKRRAIESMEQQLS 1034
            K ++ ++ +  E Q QLEK  +E +EKEK       EL       D       ++EQ+L 
Sbjct: 306  KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK 365

Query: 1035 ELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
            +L + LS  +   + A  R S     +++ +   +E ++     Q   +  + + A   +
Sbjct: 366  KLTEDLSCQRQNAESA--RCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423

Query: 1095 ALQAAKE-------QVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
             LQ AK        ++ K+ SV+Q LE   ++ + +L   + ++ +  ++ ++E+ + + 
Sbjct: 424  ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF-QASQIKENELRRSM- 481

Query: 1148 RCEDLEKQNRLLHDQIEKLSDKV------VASVKEGVQGPLNVS--LSEEGKSQEQILEI 1199
              E+++K+N LL    E+ + +V      + ++K+ +    N +  +  +  SQE +L  
Sbjct: 482  --EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539

Query: 1200 L--RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA 1257
            L  +  ++E  +   + ++A  +  + R   + L ++ +   + LN +  K +  +K + 
Sbjct: 540  LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599

Query: 1258 QHEELMKKT-ETMNVVMETNKMLREEKERL----EQDLQQMQAKVRKLELDILPLQEANA 1312
               EL KK  E +          + E E+L    E + + +Q+K+  LE  +   Q  + 
Sbjct: 600  SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659

Query: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE----EYRKLLSEKEV----H 1364
            E +E+   L+ +++ L  ++     RN H V   K  + E     Y +L  + E     H
Sbjct: 660  EYNERVRTLEMDRENLSVEI-----RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714

Query: 1365 TKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ---KDLDAKI 1421
             K I+ +  +  +L  ++      L    N I         +  E E+++   K  DA +
Sbjct: 715  QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774

Query: 1422 IDIQEKVKTITQVKK-----------IGRR--YKTQYEELKAQQDK-------------- 1454
            +  ++  +++    +           IG +    ++  E + + D+              
Sbjct: 775  VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834

Query: 1455 ---VMETSAQSSGDHQEQ-HVSVQEMQELKETLNQAETKSKSL----ESQVENLQK---- 1502
                +E+  Q + D Q+Q    VQ   E++E L +AE   +S       ++  LQ+    
Sbjct: 835  LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA 894

Query: 1503 ----------TLSEKETEARNLQEQTVQLQSELSRLRQD--LQDRTTQEEQLRQQITEKE 1550
                       L  KE E + L ++    Q+E+  L++   L + + +E QL  +    E
Sbjct: 895  HQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLE 954

Query: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI 1610
            +K   +I++   +        ++LT+EN  LK+ N +L+Q+K    + +      +   I
Sbjct: 955  KKEMSSIISLNKREI------EELTQENGTLKEINASLNQEK----MNLIQKSESFANYI 1004

Query: 1611 SRLERELREHQERHLEQR 1628
               E+ + E  +++ +++
Sbjct: 1005 DEREKSISELSDQYKQEK 1022


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score =  183 bits (464), Expect = 2e-45
 Identities = 370/1842 (20%), Positives = 769/1842 (41%), Gaps = 315/1842 (17%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGR---HEKFKVESEQQYFEIEKRL 61
            LQ+ ++  E+ +  K V+N  ++ + ++++ I+ L  +    EK  +E + +    +K L
Sbjct: 301  LQEKIKVYEMEQ-DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359

Query: 62   SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRN----------- 106
               QE++V + +E ++++LEL     + +  +E+ K+L    E  Q RN           
Sbjct: 360  GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419

Query: 107  IAIQSQFTRTKEELEAE------------KRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154
              ++ +  R  E+L AE            K++LIR  + ++Q  E  T     +   L+ 
Sbjct: 420  QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGEMENALRS 477

Query: 155  -SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
             SN T  E Q+KL  +  +++++K ++   ++EK         L  EL    +E  AL R
Sbjct: 478  YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK---------LKEELGLILEEKCALQR 528

Query: 214  EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273
            +  + + EL  + E  +     + EQ + L  +++ L   VEDL  ++  A E +  +E 
Sbjct: 529  QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VEDLKAEIVSASESRKELEL 587

Query: 274  KFHNEL-NAHIKLSNL--YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD---- 326
            K   E+ N  IKL  L   K+A  D  A+S E          L     E +K  +D    
Sbjct: 588  KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647

Query: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386
            H + +E+ KD +     ++I  L+ E+    + +   K        + +  +S       
Sbjct: 648  HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS------- 700

Query: 387  KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446
                   KL +L  + V +         +++ +   ++E+ KE+E    IL+++ +E   
Sbjct: 701  -------KLKDLQQSLVNS---------KSEEMTLQINELQKEIE----ILRQEEKEKGT 740

Query: 447  AQKAVASLSVK---LEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVK---DLSQQ 499
             ++ V  L +K   LE+ MKE +  LQE   +   ++S+L+ + + +E  +K    +SQ+
Sbjct: 741  LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800

Query: 500  IRVLLMELEEARGNHVIRDEEV-----SSADISSSSEVISQHLVSYR------------N 542
             R++ ++  +++    + ++E+      + D+      +++ +   R            N
Sbjct: 801  ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860

Query: 543  IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
             +ELQ++   LL    +L +++ ++E E  S      +LK   AL E   L++     ++
Sbjct: 861  YQELQEEYACLLKVKDDLEDSKNKQELEYKS------KLK---ALNEELHLQRINPTTVK 911

Query: 603  LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
            +  S+    D   +  +   G  +    + L +    +  ++   SQ +S        + 
Sbjct: 912  MKSSVF-DEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS--------DL 962

Query: 663  TEAIEAK-AALKQLQEIFENYKKEKAENEKIQNEQLEKL--QEQVTDLRSQNTKISTQLD 719
            +E ++ K   +  L E  ++ K+EK E   ++  +LE +    +  +++S +T++S+ LD
Sbjct: 963  SEQLKQKHGEISFLNEEVKSLKQEK-EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021

Query: 720  FASKRYEMLQDNVEGYRREITSLHERNQKL------------TATTQKQEQIINTMTQDL 767
                   M     EG   ++        K+                 KQEQ+I      +
Sbjct: 1022 GV---VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078

Query: 768  RGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT--IQGI 825
               +   A      + L+KE  +LK        ++  L  +   Q + L+ + +  +  +
Sbjct: 1079 TKESSLRATQPSENDKLQKELNVLK-------SEQNDLRLQMEAQRICLSLVYSTHVDQV 1131

Query: 826  LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
             E  E E  + L S    L+ E+   +++   E+++ H     L++Q + T+   D    
Sbjct: 1132 REYMENEKDKALCS----LKEELIFAQEEKIKELQKIH----QLELQTMKTQETGDEGKP 1183

Query: 886  LHLNTKELLKNAQKEIATLKQHLSN---------MEVQVASQSSQRTGKGQPSNKEDVDD 936
            LHL   +L K   +E +   Q L +         ++ +V ++  + +G     N++    
Sbjct: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED---- 1239

Query: 937  LVSQLRQTEEQVNDLKERLKTSTSNV-EQYQAMV---TSL----------------EESL 976
               +L+    +V D +E + T  + V E+Y  ++   T L                EE+L
Sbjct: 1240 --PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL 1297

Query: 977  NKEK--------QVT--EEVRKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRA 1025
             KE+        Q+T  E++  N + +L    + + T+LE+++ E+E     LQ   +  
Sbjct: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKET 1357

Query: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR------------------- 1066
             ++ E ++  L+K L +V            + +  E  A+R                   
Sbjct: 1358 EQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFS 1417

Query: 1067 ---DCQEQAKIAVEAQNKYERELMLHAADV-EALQAAKEQVSKMASVRQHLEET-TQKAE 1121
                 +E+  I    + +Y+ +L    A V  ++  A  Q ++++ +    E T + K  
Sbjct: 1418 GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQA 1477

Query: 1122 SQLLECKASWEERERMLKDEVSKCVCRCEDL--EKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
              + + +  +    ++ +D++        D+  +++ + L  ++ +   +++ S  +   
Sbjct: 1478 HAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHD 1537

Query: 1180 GPLN----VSLSEEGKSQEQILEILRFIRREKEIA------ETRFEVAQVESLR------ 1223
             P +    +++SEE  S+++   + + I  E  ++      +      Q+E +R      
Sbjct: 1538 IPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQ 1597

Query: 1224 ---YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
               ++Q  ELL +      +    ++E++Q   K + +        +  N+V E  ++L 
Sbjct: 1598 YQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLL 1657

Query: 1281 EEKERLEQ-DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL--LEEDVKRWKA 1337
            EE E L+Q  L   +    +L       Q  N    E       EK+L    EDV     
Sbjct: 1658 EELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEIL 1717

Query: 1338 RNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL------KAEIARSNASLTN 1391
             N+    Q+ +       K+L E    T  ++   E IGR       ++  ++S+ASL  
Sbjct: 1718 SNERYALQKAN---NRLLKILLEVVKTTAAVE---ETIGRHVLGILDRSSKSQSSASLIW 1771

Query: 1392 NQNLIQSLKEDLNK--VRTEKETIQ----KDLDAKIIDIQEKV--------KTITQVKKI 1437
                  S+K  +++   R   E+I      D+    I++  KV        + + +    
Sbjct: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831

Query: 1438 GRRYKTQYEE--------LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETK 1489
            G     + EE        L+A  +K++E  +++S   Q +H  V + + ++E+  Q +  
Sbjct: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEA 1889

Query: 1490 SKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK 1549
            ++SL+ Q E L++ L E E+ AR       QL  ELS+    +     ++    +QI EK
Sbjct: 1890 TESLKCQ-EELRERLHE-ESRARE------QLAVELSKAEGVIDGYADEKTLFERQIQEK 1941

Query: 1550 E---EKTRKAIVAAKSKIAHLAGVKDQ-------LTKENEELKQRNGALDQQ-------- 1591
                ++  + ++ A +++  L   + Q       L+++ E +K   G ++QQ        
Sbjct: 1942 TDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL 2001

Query: 1592 -KDELDVRITA--LKSQYEGRISRLERELREHQERHLEQRDE 1630
             K++L+V+  A  ++   + ++  LE ++ E   R +E   E
Sbjct: 2002 MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQE 2043



 Score =  150 bits (380), Expect = 1e-35
 Identities = 332/1711 (19%), Positives = 678/1711 (39%), Gaps = 248/1711 (14%)

Query: 49   ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA 108
            E E+Q F+ EK L    E +  E    +  R  L+K NN+L  +  +  +   A +  I 
Sbjct: 1694 EVEEQTFK-EKELDRKPEDVPPEILSNE--RYALQKANNRLLKILLEVVKTTAAVEETIG 1750

Query: 109  IQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE 168
                    +         LI  +E  +     + E+  R+ ++   S +          +
Sbjct: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGS--------D 1802

Query: 169  LQASDVSV--KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
            +  +D+++  K  E+  E  + L+ S   +  TE+  + +EL+       N    L+  +
Sbjct: 1803 MPRNDINMWSKVTEEGTELSQRLVRSG--FAGTEIDPENEELML------NISSRLQAAV 1854

Query: 227  ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLS 286
            E   E +S    Q+   K +   L +       +  E+ + Q  + E+ H E  A  +L+
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914

Query: 287  NLYKSA-------ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQME 339
                 A       AD+      ++    + + +L +E   A+  +Q+  LE EQ + Q E
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE--LEAEQQQIQEE 1972

Query: 340  KEMLEK--------IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
            +E+L +         G +E++L    + L   K +    +E+    +     A+   V+ 
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032

Query: 392  GM---------KLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQRE 442
             +         K TEL +  +  Q+Q L ++LE  R  K+LDE   + E +  + +++ +
Sbjct: 2033 QVSRFIELEQEKNTELMD--LRQQNQALEKQLEKMR--KFLDEQAIDREHERDVFQQEIQ 2088

Query: 443  EYERAQKAVASLSVKLEQAMKEIQRL----QEDTDKANK--------QSSVLERDNR--R 488
            + E+  K V       E   +E+++L    +E TDK ++        Q  + ER+    +
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK 2148

Query: 489  MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ 548
            +E +V++L Q    LL+E  +  G    + E      + +  + I +      N+EE  +
Sbjct: 2149 LEFRVRELEQ---ALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205

Query: 549  QNQRLLVALRELGETREREEQETTSSKITELQLKLE-------SALTELEQLRKSRQHQM 601
            Q                REE E  + ++ +L ++LE       + L ELEQ  K  +  M
Sbjct: 2206 QF---------------REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2250

Query: 602  QLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTS---QTVSTPAPVP 658
            + +   +++ D    + +Q   V     A  + +  +         +   Q +       
Sbjct: 2251 EKLGLAIKESDA---MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2307

Query: 659  VIESTEAI--EAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNT---- 712
            VIE    +  + +  ++ L    E  K+ + E  +  NE +EKLQ+++ ++  + +    
Sbjct: 2308 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2367

Query: 713  -------KISTQLDFASKRYEMLQDNVEGYRREITS----LHERNQKLTATTQKQEQIIN 761
                    +  QLD        L+  VE    E+T     L E N K+   TQ+    + 
Sbjct: 2368 SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQE----LF 2423

Query: 762  TMTQDLRGANEKLAVAE----VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT 817
            ++ ++     +  ++ E    V  ++L K+K  L   EV L+   E  L     Q    +
Sbjct: 2424 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL---EVVLT---EDALKSLENQTYFKS 2477

Query: 818  NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
              +  +G +   ET   Q L S +   + E++   K++++  EQ    T  L  ++++ +
Sbjct: 2478 FEENGKGSIINLETRLLQ-LESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536

Query: 878  RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
            + ++ +    L   ++   A +E A   Q     + Q  S   +RT              
Sbjct: 2537 KIVEEKVAAAL-VSQIQLEAVQEYAKFCQ-----DNQTISSEPERTN------------- 2577

Query: 938  VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
            +  L Q  E  ++L   +   T  + + ++ V  +  SL  EK+  E   KN+  + K+ 
Sbjct: 2578 IQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2635

Query: 998  AEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA 1057
             E Q     KL+E  ++KQ  ++ KR       Q +  LK T     +  +        A
Sbjct: 2636 LELQ-----KLLEGNEKKQREKEKKRSP-----QDVEVLKTTTELFHSNEESGFFNELEA 2685

Query: 1058 LSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETT 1117
            L  E  A +   E A    +A+ K + EL++   ++ +LQ        ++ VR HL E  
Sbjct: 2686 LRAESVATK--AELASYKEKAE-KLQEELLVKETNMTSLQ------KDLSQVRDHLAEAK 2736

Query: 1118 QKAESQLLECKASWEERERMLKDEVSKCVCRCEDLE-KQNRLLHDQIE---KLSDKVVAS 1173
            +K    +LE +   E +E       SK  C  E L  K ++ +  Q +   K+S      
Sbjct: 2737 EKLS--ILEKEDETEVQE-------SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTP 2787

Query: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF---------EVAQVESLRY 1224
                    + ++L  E  S+E    I +F  + +++ E             +++ E+L+ 
Sbjct: 2788 QILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKR 2847

Query: 1225 RQ--RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKK----------------- 1265
                 V+LL+ E   L+  +   R K   +   +A  +    +                 
Sbjct: 2848 EHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYL 2907

Query: 1266 TETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLE---LDILPLQEANAELSEKSGMLQ 1322
            T +    + +     E +   +   ++++  +R +    + +L L E+     E   + Q
Sbjct: 2908 THSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQ 2967

Query: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
              +  LEE     +    + +S  KD  T+   +L  E EV+       +    R +  +
Sbjct: 2968 VSEPWLEE-----RKAYINTISSLKDLITK--MQLQREAEVYDSSQSHESFSDWRGELLL 3020

Query: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKET-----IQKDLDAKIIDIQEKVKTITQVKKI 1437
            A     L     L+ + + +L  + T         +++ +  + ++ Q  ++ + +  + 
Sbjct: 3021 ALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR- 3079

Query: 1438 GRRYKTQYEELKAQQD-KVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQ 1496
             R   ++ + L AQ + + +    +   +   Q +    +Q+ +  + + + +  S++ +
Sbjct: 3080 -RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR 3138

Query: 1497 VENLQKTLSEKETEARNLQEQTVQLQ--------------SELSRLRQDLQDRTTQEEQL 1542
               LQ+ LS ++     L+ +  Q +               EL   R +++D+T +   L
Sbjct: 3139 ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3198

Query: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEEL-------KQRNGALDQQKDEL 1595
               +  +++K+R+   A + + A L   +++  +E E+L       KQRN  L+   ++ 
Sbjct: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258

Query: 1596 DVRITALKSQYEGRISRLERELREHQERHLE 1626
               +   + + E +    + +L E Q R+LE
Sbjct: 3259 KQLLNESQQKIESQRMLYDAQLSEEQGRNLE 3289



 Score =  143 bits (361), Expect = 2e-33
 Identities = 315/1691 (18%), Positives = 680/1691 (40%), Gaps = 231/1691 (13%)

Query: 10   ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
            E TE   +   + N LE    + +S++  L+   EK K+E + Q  E+E  +S  Q++L 
Sbjct: 1300 EETEFLSIHSQMTN-LEDIDVNHKSKLSSLQDL-EKTKLEEQVQ--ELESLISSLQQQL- 1354

Query: 70   NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
             ET   Q+   E+  L  +L+A++E      +  D  +  +S   RT       K+++  
Sbjct: 1355 KETE--QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDG 1412

Query: 130  TNE-----RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLE 184
            T E      + +E   +    K+  E+L+E    K  + + +   Q +++S     K   
Sbjct: 1413 TIEFSGEFGVKEETNIVKLLEKQYQEQLEEE-VAKVIVSMSIAFAQQTELSRISGGKENT 1471

Query: 185  QEKELLHS---QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMN 241
               +  H+   Q      E+K   D++      +  E +++K      KEE   L +++ 
Sbjct: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQI----GFQTFETVDVKF-----KEEFKPLSKELG 1522

Query: 242  G------LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADD 295
                   L  S+ H     +D +  + E   +  S ++ F    + H ++S     A+  
Sbjct: 1523 EHGKEILLSNSDPHDIPESKDCVLTISE---EMFSKDKTFIVRQSIHDEISVSSMDASRQ 1579

Query: 296  SEAKSNELTRAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELE 354
                  +L    +EL +  +E  +A + + Q H+ ++E+ ++  E ++ E+I RL ++L 
Sbjct: 1580 LMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLA 1638

Query: 355  NANDLLS---ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
              + + +    ++R+  +L E E       A       +     T+  N   E Q ++  
Sbjct: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEE 1697

Query: 412  EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLS---VKLEQAMKE---- 464
            +  + K +++  +++  E      IL  +R   ++A   +  +    VK   A++E    
Sbjct: 1698 QTFKEKELDRKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751

Query: 465  -IQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
             +  + + + K+   +S++ R      ++     +  RV    +    G+ + R++    
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811

Query: 524  ADISSSSEVISQHLVSY---------RNIEELQQQNQRLLVALRELGETREREEQETTSS 574
            + ++     +SQ LV            N E +   + RL  A+ +L E       +   +
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871

Query: 575  KITELQLKLESALTELEQLR--KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
            K+T+ +L  ES   + E     K ++   + +    R R+   + LS+  GV        
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGY 1927

Query: 633  LDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKA----- 687
             D+ +L     +  T   +       +  S    E +A  +Q+QE  E   ++K      
Sbjct: 1928 ADEKTLFERQIQEKTD-IIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE 1986

Query: 688  ----------ENEKIQNEQLE---------------------KLQEQVT----------- 705
                      E EK+  E+LE                      ++EQV+           
Sbjct: 1987 AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT 2046

Query: 706  ---DLRSQNTKISTQLD----FASKRYEMLQDNVEGYRREITSLHE------RNQKLTA- 751
               DLR QN  +  QL+    F  ++    +   + +++EI  L +      R Q ++  
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH 2106

Query: 752  TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
             T++ EQ+ N + +     +E L   E    ++++  E ++  E R+ +  ++LL E R 
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRK 2166

Query: 812  Q-NLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD 870
                +    +    +  ++E +   R   +I  LE ++   +++LEN+ E+   L   L+
Sbjct: 2167 HFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE 2226

Query: 871  VQLLDTK---RQLDTETNLHLNTKELLKNAQKE---IATLKQH---------LSNMEVQV 915
            +Q  ++    ++L+ E  L  +  E L  A KE   ++T  QH         +   EV++
Sbjct: 2227 IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 2286

Query: 916  ASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE----QYQAMVTS 971
              Q +++  K Q   K   D+ V  + +  E + DL+ +++   S+ E      +  +  
Sbjct: 2287 -DQLNEQVTKLQQQLKITTDNKV--IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343

Query: 972  LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQ 1031
            L E + K +Q    + +   +     +E    L+ +L  V  EK  L+     A E M  
Sbjct: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403

Query: 1032 QLSELKKTLSSVQNEVQE--ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLH 1089
              + LK+T   +    QE  +L+R   ++   Q      +    +A++  +K + EL + 
Sbjct: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP---ENSVNVAIDHLSKDKPELEVV 2460

Query: 1090 AADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRC 1149
              + +AL++ + Q +   S  ++ + +    E++LL+ +++   ++     E+++C  + 
Sbjct: 2461 LTE-DALKSLENQ-TYFKSFEENGKGSIINLETRLLQLESTVSAKDL----ELTQCYKQI 2514

Query: 1150 EDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEI 1209
            +D+++Q +   + ++K    +   V+E V   L   +  E      + E  +F +  + I
Sbjct: 2515 KDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-----VQEYAKFCQDNQTI 2569

Query: 1210 AET--RFEVAQVESLRYRQ----------RVELLERELQELQDSLNAEREKVQVTAKTMA 1257
            +    R  +  +  LR  +          R+  LE ++ E+  SL  E+E+V++  K + 
Sbjct: 2570 SSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL 2629

Query: 1258 QHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEK 1317
            + E   KK   +  ++E N+  + EKE                                 
Sbjct: 2630 EKE---KKLLELQKLLEGNEKKQREKE--------------------------------- 2653

Query: 1318 SGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR 1377
                   KK   +DV+  K   +   S ++     E   L +E       +    E+  +
Sbjct: 2654 -------KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2706

Query: 1378 LKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKI 1437
            L+ E+     ++T+ Q  +  +++ L + + +   ++K+ + ++ + ++         K+
Sbjct: 2707 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKL 2766

Query: 1438 GRRYKTQYE-ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLE-- 1494
             +   +Q +  LK             +   Q    S    +E+ E ++Q   K + ++  
Sbjct: 2767 SKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2826

Query: 1495 --SQVENLQ-KTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
              +++ +++ + +SE ET  R        L+ E   L+  +Q   ++E     ++   + 
Sbjct: 2827 HAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDA 2886

Query: 1552 KTRKAIVAAKS 1562
               + I ++ S
Sbjct: 2887 YQTREICSSDS 2897



 Score =  138 bits (347), Expect = 7e-32
 Identities = 318/1616 (19%), Positives = 661/1616 (40%), Gaps = 211/1616 (13%)

Query: 8    VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
            V  +++L+ L    + KLE+ + + +S I  L+ + ++ +   E +   ++KRL    E 
Sbjct: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378

Query: 68   LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
             V  +    S+ +        +   +   K +    D  I    +F   KEE    K   
Sbjct: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNI----DGTIEFSGEF-GVKEETNIVKLLE 1433

Query: 128  IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
             +  E+L +E+  +   +     +  E +   G  +      QA   +V  +E+    E 
Sbjct: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--AVCQQEQHYFNEM 1491

Query: 188  ELLHSQ---NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
            +L   Q    T+   ++K K +E   L +E G          E+ KE +         L 
Sbjct: 1492 KLSQDQIGFQTFETVDVKFK-EEFKPLSKELG----------EHGKEIL---------LS 1531

Query: 245  TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
             S+ H     +D +  +    E+  S ++ F    + H ++S     A+        +L 
Sbjct: 1532 NSDPHDIPESKDCVLTI---SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLE 1588

Query: 305  RAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS-- 361
               +EL +  +E  +A + + Q H+ ++E+ ++  E ++ E+I RL ++L   + + +  
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLAQRSSIDNEN 1647

Query: 362  -ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
              ++R+  +L E E       A       +     T+  N   E Q ++  +  + K ++
Sbjct: 1648 LVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEEQTFKEKELD 1706

Query: 421  KYLDEIVKEVEAKAPILKRQREEYERAQKAVASL---SVKLEQAMKE-----IQRLQEDT 472
            +  +++  E      IL  +R   ++A   +  +    VK   A++E     +  + + +
Sbjct: 1707 RKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760

Query: 473  DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532
             K+   +S++ R      ++     +  RV    +    G+ + R++    + ++     
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820

Query: 533  ISQHLV---------SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583
            +SQ LV            N E +   + RL  A+ +L E       +   +K+T+ +L  
Sbjct: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880

Query: 584  ES--ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
            ES     E  +  K ++   + +    R R+   + LS+  GV         D+ +L   
Sbjct: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGYADEKTLFER 1936

Query: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEK--------------- 686
              +  T   +       +  S    E +A  +Q+QE  E   ++K               
Sbjct: 1937 QIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995

Query: 687  AENEKIQNEQLE----------KLQEQV-------------------------TDLRSQN 711
             E EK+  E+LE           LQ+QV                          DLR QN
Sbjct: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQN 2055

Query: 712  TKISTQLD----FASKRYEMLQDNVEGYRREITSLHE------RNQKLTA-TTQKQEQII 760
              +  QL+    F  ++    +   + +++EI  L +      R Q ++   T++ EQ+ 
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLA 2115

Query: 761  NTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ-NLLLTNL 819
            N + +     +E L   E    ++++  E ++  E R+ +  ++LL E R     +    
Sbjct: 2116 NHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKP 2175

Query: 820  QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK-- 877
            +    +  ++E +   R   +I  LE ++   +++LEN+ E+   L   L++Q  ++   
Sbjct: 2176 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 2235

Query: 878  -RQLDTETNLHLNTKELLKNAQKE---IATLKQH---------LSNMEVQVASQSSQRTG 924
             ++L+ E  L  +  E L  A KE   ++T  QH         +   EV++  Q +++  
Sbjct: 2236 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI-DQLNEQVT 2294

Query: 925  KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE----QYQAMVTSLEESLNKEK 980
            K Q   K   D+ V  + +  E + DL+ +++   S+ E      +  +  L E + K +
Sbjct: 2295 KLQQQLKITTDNKV--IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2352

Query: 981  QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
            Q    + +   +     +E    L+ +L  V  EK  L+     A E M    + LK+T 
Sbjct: 2353 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2412

Query: 1041 SSVQNEVQE--ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA 1098
              +    QE  +L+R   ++   Q      +    +A++  +K + EL +   + +AL++
Sbjct: 2413 FKMNQLTQELFSLKRERESVEKIQSIP---ENSVNVAIDHLSKDKPELEVVLTE-DALKS 2468

Query: 1099 AKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRL 1158
             + Q +   S  ++ + +    E++LL+ +++   ++     E+++C  + +D+++Q + 
Sbjct: 2469 LENQ-TYFKSFEENGKGSIINLETRLLQLESTVSAKDL----ELTQCYKQIKDMQEQGQF 2523

Query: 1159 LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE--TRFEV 1216
              + ++K    +   V+E V   L   +       E + E  +F +  + I+    R  +
Sbjct: 2524 ETEMLQKKIVNLQKIVEEKVAAALVSQI-----QLEAVQEYAKFCQDNQTISSEPERTNI 2578

Query: 1217 AQVESLRYRQ----------RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT 1266
              +  LR  +          R+  LE ++ E+  SL  E+E+V++  K + + E   KK 
Sbjct: 2579 QNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE---KKL 2635

Query: 1267 ETMNVVMETN--KMLREEKERLEQDLQQMQAKVRKL----------ELDILPLQEANAEL 1314
              +  ++E N  K   +EK+R  QD++ ++                EL+ L  +    + 
Sbjct: 2636 LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKA 2695

Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARN-QHLVSQQKDPDTEEYRKL-LSEKEVHTKRIQQLT 1372
               S   +AEK   E  VK     + Q  +SQ +D   E   KL + EKE  T+ +Q+  
Sbjct: 2696 ELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE-VQESK 2754

Query: 1373 EE--IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII--DIQEKV 1428
            +      L  ++++S AS T+    I S      ++  +   IQ +L ++    ++ E +
Sbjct: 2755 KACMFEPLPIKLSKSIASQTDGTLKISS-SNQTPQILVKNAGIQINLQSECSSEEVTEII 2813

Query: 1429 KTITQ-VKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETL 1483
               T+ ++K+   +  +  +++++     ET        +E +V+VQ ++E   TL
Sbjct: 2814 SQFTEKIEKMQELHAAEILDMESRHISETETL------KREHYVAVQLLKEECGTL 2863



 Score =  136 bits (343), Expect = 2e-31
 Identities = 370/1864 (19%), Positives = 738/1864 (39%), Gaps = 314/1864 (16%)

Query: 12   TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
            T+++ L   V     +      S+++   G   K  VE +  +  +       QE+L+ +
Sbjct: 1014 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD 1073

Query: 72   -----TRECQSLRL----ELEKLNNQLKALTEKNKELEIAQDR-----NIAIQSQFTRTK 117
                 T+E  SLR     E +KL  +L  L  +  +L +  +      ++   +   + +
Sbjct: 1074 HLPSVTKE-SSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVR 1132

Query: 118  EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
            E +E EK   + +   L +EL +  E+  +  +K+ +      + Q   DE +   + + 
Sbjct: 1133 EYMENEKDKALCS---LKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIG 1189

Query: 178  YREKRLEQE-----KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN--LENKK 230
              +K + +E     + L      +    LK    E+ A  +E   + +    +  L++ +
Sbjct: 1190 KLQKAVSEECSYFLQTLCSVLGEYYTPALKC---EVNAEDKENSGDYISENEDPELQDYR 1246

Query: 231  EEVSRLEEQMNGL--KTSNEH-----LQKHVEDLL------TKLKEAKEQQASMEEKF-- 275
             EV   +E M+ L  K + E+     LQ  +  +        KL+  +E     E +F  
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306

Query: 276  -HNEL--------NAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
             H+++        N   KLS+L        + +  +L   V+EL  L+        ++Q 
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSL-------QDLEKTKLEEQVQELESLI-------SSLQQ 1352

Query: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENAND--LLSATKRKGAILSEEELAAMSPTAAA 384
             L E EQ+ +        +I  L+K L+  ++  +  +      +++E +        + 
Sbjct: 1353 QLKETEQNYE-------AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSC 1405

Query: 385  VAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEY 444
            V K +   ++ +  +    ET     + KL  K+  + L+E V +V     I   Q+ E 
Sbjct: 1406 VKKNIDGTIEFSGEFGVKEETN----IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTEL 1461

Query: 445  ER--------AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDL 496
             R        A    A    + EQ      +L +D        +V  +     +   K+L
Sbjct: 1462 SRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521

Query: 497  SQQIRVLLM------ELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
             +  + +L+      ++ E++   +   EE+ S D    + ++ Q +    ++  +    
Sbjct: 1522 GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKD---KTFIVRQSIHDEISVSSMDASR 1578

Query: 551  QRLL--VALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
            Q +L    L ++ +   R+ QE    + TEL  +       + Q+ + R+ Q QL + I 
Sbjct: 1579 QLMLNEEQLEDMRQELVRQYQE--HQQATELLRQ-----AHMRQMERQREDQEQLQEEIK 1631

Query: 609  R------QRDMY--RILLSQTTGVAIPLHASSLDDVSLASTPK-----RPSTSQTVSTPA 655
            R      QR       L+S+   V +     +L  +SLA   K     R S++QT +   
Sbjct: 1632 RLNRQLAQRSSIDNENLVSERERVLLE-ELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690

Query: 656  PVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL-------- 707
                +E     E +   K      E    E+   +K  N  L+ L E V           
Sbjct: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750

Query: 708  --------RSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759
                    RS  ++ S  L + S+    ++  V      +T     +   +   +    +
Sbjct: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810

Query: 760  INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLS-EVRLSQQRESLLAEQRGQNLLLTN 818
             + +T++    +++L  +      +  E E L L+   RL    E LL      +  L +
Sbjct: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870

Query: 819  LQTIQGILERSETETKQRLSSQIEKLE------HEISHLKKKLENEVEQRHTLTRNLDVQ 872
             +  Q  L R     KQ  +  ++  E      HE S  +++L  E+ +   +      +
Sbjct: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930

Query: 873  LLDTKRQLDTETNLHLNTKELL---KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929
                +RQ+  +T++    ++ L    N  +E+   +Q +      ++ Q      +  P 
Sbjct: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990

Query: 930  NKEDVDDLVSQLR-------QTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQV 982
             ++ + +    ++       Q E+  +DL++++K    +VE+  +    LE+  N E   
Sbjct: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050

Query: 983  TEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL------ 1036
              +  + +E +L++  +F   L+++ ++ E E+   Q +    I+ +EQQL  +      
Sbjct: 2051 LRQQNQALEKQLEKMRKF---LDEQAIDREHERDVFQQE----IQKLEQQLKVVPRFQPI 2103

Query: 1037 ----KKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQ---NKYERELML- 1088
                 + +  + N ++E   + S  L +++Q +RD QE+ +   + +    + E+ L++ 
Sbjct: 2104 SEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE 2163

Query: 1089 ---HAADVEA---------LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
               H   VEA         LQA ++ + +      +LEE  ++   +L       ++   
Sbjct: 2164 DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2223

Query: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI 1196
             L+ +  +   R ++LE++N+L  D +EKL               L +  S+   +Q+Q 
Sbjct: 2224 QLEIQKKESTTRLQELEQENKLFKDDMEKLG--------------LAIKESDAMSTQDQH 2269

Query: 1197 LEILRF--IRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
            +   +F  I +EKE+     E+ Q+      ++V  L+++L+   D+   E EK ++   
Sbjct: 2270 VLFGKFAQIIQEKEV-----EIDQL-----NEQVTKLQQQLKITTDNKVIE-EKNELIRD 2318

Query: 1255 TMAQHEELMKKTETMNVVMETN-KMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAE 1313
               Q E LM   E +    E   + L E  E+L+Q+L  +    +K  ++   L E    
Sbjct: 2319 LETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG---QKTSMNAHSLSEEADS 2375

Query: 1314 LSEKSGMLQAEKKLLEEDVK------------------RWKARNQHLVSQQKDPDTEEYR 1355
            L  +  ++ AEK  LE+ V+                  +     Q L S +++ ++ E  
Sbjct: 2376 LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2435

Query: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKE---------DLNKV 1406
            + + E  V+   I  L+++   L+  +         NQ   +S +E         +   +
Sbjct: 2436 QSIPENSVNV-AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL 2494

Query: 1407 RTEKETIQKDLD-----AKIIDIQEKVKTITQV--KKIGRRYKTQYEELKAQ-----QDK 1454
            + E     KDL+      +I D+QE+ +  T++  KKI    K   E++ A      Q +
Sbjct: 2495 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2554

Query: 1455 VMETSAQSSGDHQ-----EQHVSVQEMQELKE----------TLNQAETKSKSLE----- 1494
             ++  A+   D+Q      +  ++Q + +L+E          TL  +E +S+ +E     
Sbjct: 2555 AVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL 2614

Query: 1495 ----SQVENLQKTLSEKETEARNLQE-----QTVQLQSELSRLRQDLQDRTTQEEQLRQQ 1545
                 QVE  +K + EKE +   LQ+     +  Q + E  R  QD++   T  E     
Sbjct: 2615 ILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN 2674

Query: 1546 ----ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITA 1601
                   + E  R   VA K   A LA  K++  K  EEL  +           +  +T+
Sbjct: 2675 EESGFFNELEALRAESVATK---AELASYKEKAEKLQEELLVK-----------ETNMTS 2720

Query: 1602 LKSQYEGRISRLERELREHQER--HLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
            L+      +S++   L E +E+   LE+ DE      +V E ++    +  P    + IA
Sbjct: 2721 LQKD----LSQVRDHLAEAKEKLSILEKEDE-----TEVQESKKACMFEPLPIKLSKSIA 2771

Query: 1660 STSD 1663
            S +D
Sbjct: 2772 SQTD 2775



 Score =  136 bits (342), Expect = 3e-31
 Identities = 285/1390 (20%), Positives = 558/1390 (40%), Gaps = 279/1390 (20%)

Query: 242  GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
            G + S  HL+    +L  K  E +E    +EE         ++    +++A    +    
Sbjct: 149  GAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIIT 208

Query: 302  ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS-KDQMEKEMLEKIGRLEKELEN--AND 358
            +LT  +++  +      E ++ +++ L   EQS K Q++ + L+    L     +  A D
Sbjct: 209  QLTANLQQARR------EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAAD 262

Query: 359  LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKR 418
            LL A   K  IL+ ++                            +E QD LL E  + K+
Sbjct: 263  LLQA---KQQILTHQQ---------------------------QLEEQDHLL-EDYQKKK 291

Query: 419  IN-----KYLDEIVK--EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
             +      +L E +K  E+E    +    +EE +  +  +  L+ K+ +  K+   L++ 
Sbjct: 292  EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 351

Query: 472  TDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE 531
               A+K    L+        Q+   +Q+I+ + +EL  ++                 SSE
Sbjct: 352  LTTADKLLGELQE-------QIVQKNQEIKNMKLELTNSKQKE------------RQSSE 392

Query: 532  VISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE 591
             I Q + +   +EELQ++N +      ++ +  E+E Q        EL       + +++
Sbjct: 393  EIKQLMGT---VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMK 449

Query: 592  QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL--ASTPKRPSTSQ 649
            Q    RQH  Q+ +   R +      L   + + +      L +V++   +   + + SQ
Sbjct: 450  Q-ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 508

Query: 650  TVSTPAPVPVIESTEAIEAKAAL-KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLR 708
                   + +I     +E K AL +QL+++ E     +   E+IQ  + + + EQ + L 
Sbjct: 509  KEKLKEELGLI-----LEEKCALQRQLEDLVEELSFSR---EQIQRAR-QTIAEQESKLN 559

Query: 709  SQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
              +  +ST               VE  + EI S  E  ++L    + + ++ N   +   
Sbjct: 560  EAHKSLST---------------VEDLKAEIVSASESRKELEL--KHEAEVTNYKIKLEM 602

Query: 769  GANEKLAVAEVRAENLKKEKEMLKLS-----EVRLSQQRESLLAEQRGQNLLLTNLQTIQ 823
               EK AV +  AE+ + E E L+       E  LS+ +E L  E R   + +  L+   
Sbjct: 603  LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR---INIEKLKDNL 659

Query: 824  GILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT 882
            GI  + + +  Q  +S +IE ++ E  +L  K +N++    +  ++L   L+++K +   
Sbjct: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITK-QNQLILEISKLKDLQQSLVNSKSE--- 715

Query: 883  ETNLHLNTK----ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            E  L +N      E+L+  +KE  TL+Q +  ++++      Q         KE  +DL 
Sbjct: 716  EMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM--------KEKENDLQ 767

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-----KEKQVTEEVRKNIEVR 993
             +  Q E + + LK+  KT    ++ +  +  S EE L      K K       K IE+ 
Sbjct: 768  EKFAQLEAENSILKDEKKTLEDMLKIHTPV--SQEERLIFLDSIKSKSKDSVWEKEIEIL 825

Query: 994  LKESAEFQTQLEKKLMEVEKEK--------------QELQDD-------KRRAIESMEQQ 1032
            ++E+ + + Q  +   E+EK++              QELQ++       K    +S  +Q
Sbjct: 826  IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885

Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV-----EAQNKYERELM 1087
              E K  L ++  E+   LQR +      + +  D +++  +A      E   K   ELM
Sbjct: 886  ELEYKSKLKALNEELH--LQRINPTTVKMKSSVFD-EDKTFVAETLEMGEVVEKDTTELM 942

Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
                  E L+  K +  +++     L E  ++   ++    +   E  + LK E  +   
Sbjct: 943  ------EKLEVTKREKLELSQRLSDLSEQLKQKHGEI----SFLNEEVKSLKQEKEQVSL 992

Query: 1148 RCEDLE---KQNRLLH-----DQIEKLSDKVVASVKEGVQGPL----------------- 1182
            RC +LE     NR  +      Q+  L D VV     G +G +                 
Sbjct: 993  RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052

Query: 1183 -----NVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
                 N+++ EE K ++ IL+ L  + +E  +  T+      E+ + ++ + +L+ E  +
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ----PSENDKLQKELNVLKSEQND 1108

Query: 1238 LQDSLNAEREKVQVTAKT-MAQHEELMKKTETMNVVMETNKMLREEKERL----EQDLQQ 1292
            L+  + A+R  + +   T + Q  E M+         E +K L   KE L    E+ +++
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMEN--------EKDKALCSLKEELIFAQEEKIKE 1160

Query: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
            +Q K+ +LEL  +  QE   E      ++   +K + E+   +                 
Sbjct: 1161 LQ-KIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF----------------- 1202

Query: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
                           +Q L   +G       +   +  + +N    + E+       ++ 
Sbjct: 1203 ---------------LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN-------EDP 1240

Query: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
              +D   ++ D QE + T+        +   +Y +L   Q ++ +   Q +         
Sbjct: 1241 ELQDYRYEVQDFQENMHTLLN------KVTEEYNKLLVLQTRLSKIWGQQTDG------- 1287

Query: 1473 VQEMQELKETLNQAETKSKSLESQVENLQ--------KTLSEKETEARNLQEQTVQLQSE 1524
              +++  +E L + ET+  S+ SQ+ NL+        K  S ++ E   L+EQ  +L+S 
Sbjct: 1288 -MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESL 1346

Query: 1525 LSRLRQDLQD 1534
            +S L+Q L++
Sbjct: 1347 ISSLQQQLKE 1356



 Score =  136 bits (342), Expect = 3e-31
 Identities = 355/1705 (20%), Positives = 686/1705 (40%), Gaps = 346/1705 (20%)

Query: 7    QVLERTELNKLPKSVQNKLEKFLADQ-----------QSEIDGLKGRHE---KFKVESEQ 52
            ++++  + N+  +    K+ KFL +Q           Q EI  L+ + +   +F+  SE 
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH 2106

Query: 53   QYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE----------IA 102
            Q  E+E+  +H +E+    T +C  L L  E+L   ++   E+ ++LE          + 
Sbjct: 2107 QTREVEQLANHLKEK----TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162

Query: 103  QDRN----------IAIQSQFTRTKEELEAEKRDLIRTNERLSQ---ELEYLTEDVKRLN 149
            +DR           ++++ Q    ++ ++ +++++    E+L Q   ELE   E+V++L+
Sbjct: 2163 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222

Query: 150  EKL----KESNTTKGELQ----LKLDELQASDVSVKYREK--------------RLEQEK 187
             +L    KES T   EL+    L  D+++   +++K  +               ++ QEK
Sbjct: 2223 MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK 2282

Query: 188  EL----LHSQNTWLNTELKTKTDELLALGREKGNEIL------------ELKCNLENKKE 231
            E+    L+ Q T L  +LK  TD  +    E+ NE++            + +C   N++E
Sbjct: 2283 EVEIDQLNEQVTKLQQQLKITTDNKVI---EEKNELIRDLETQIECLMSDQECVKRNREE 2339

Query: 232  EVSRLEEQMN---------GLKTS-NEH-LQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
            E+ +L E +          G KTS N H L +  + L  +L     ++ ++E++      
Sbjct: 2340 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2399

Query: 281  AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV---EQSKDQ 337
                + N+ K    ++  K N+LT+ +  L K  +E+ E  ++I ++ + V     SKD+
Sbjct: 2400 EMTFMKNVLK----ETNFKMNQLTQELFSL-KRERESVEKIQSIPENSVNVAIDHLSKDK 2454

Query: 338  MEKEMLEKIGRLEKELENANDLLSATKR-KGAILS-EEELAAMSPTAAAVAKIVKPGMKL 395
             E E++     L K LEN     S  +  KG+I++ E  L  +  T +A        ++L
Sbjct: 2455 PELEVVLTEDAL-KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSA------KDLEL 2507

Query: 396  TELYNAYVETQDQ--LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEY-ERAQKAVA 452
            T+ Y    + Q+Q     E L+ K +N  L +IV+E  A A + + Q E   E A+    
Sbjct: 2508 TQCYKQIKDMQEQGQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQD 2565

Query: 453  SLSVKLEQAMKEIQRLQE-DTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
            + ++  E     IQ L +   D+     S L      +E QV ++   + +   ++E A 
Sbjct: 2566 NQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE 2625

Query: 512  GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
             N + +++++             Q L+     ++ +++ +R    +  L  T E      
Sbjct: 2626 KNVLEKEKKLLEL----------QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE 2675

Query: 572  TSSKITELQ-LKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL--LSQTTGVAIPL 628
             S    EL+ L+ ES  T+ E      + +    + +V++ +M  +   LSQ        
Sbjct: 2676 ESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL--- 2732

Query: 629  HASSLDDVSLAS----TPKRPSTSQTVSTPAPVPVIES----TEAIEAKAALKQLQEIFE 680
             A + + +S+      T  + S    +  P P+ + +S    T+     ++  Q  +I  
Sbjct: 2733 -AEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL- 2790

Query: 681  NYKKEKAENEKIQ-NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREI 739
                   +N  IQ N Q E   E+VT++ SQ T             E ++   E +  EI
Sbjct: 2791 ------VKNAGIQINLQSECSSEEVTEIISQFT-------------EKIEKMQELHAAEI 2831

Query: 740  TSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLS 799
              +  R+   T T +++  +   + ++  G  +    A ++    K+   + +L+     
Sbjct: 2832 LDMESRHISETETLKREHYVAVQLLKEECGTLK----AVIQCLRSKEGSSIPELAHSDAY 2887

Query: 800  QQRESLLAEQR---GQNLLLTNLQ----------------------TIQGILERSETETK 834
            Q RE   ++     GQ + LT+ Q                       I+G+L     E  
Sbjct: 2888 QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGM 2947

Query: 835  QRLS-SQIEKLEHEISHLKKKLENEVEQRHTLTRNLD-VQLLDTKRQLDTETNLHLNTKE 892
            Q LS ++    + E   +++  E  +E+R      +  ++ L TK QL  E  ++ +++ 
Sbjct: 2948 QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQS 3007

Query: 893  -------------------------LLKNAQKEIATLKQH-----LSNMEVQVASQSSQR 922
                                     LL   + E+  L        L+ +E ++  Q  + 
Sbjct: 3008 HESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEY 3067

Query: 923  TGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS-----------NVEQYQAMV-- 969
                +   K D   L+S+++    Q+N  K  LK               N++Q Q+ +  
Sbjct: 3068 QAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLE 3127

Query: 970  ------------TSLEESLNKEKQVTEEVRKNI-------EVRLKESAEFQTQLEKKLME 1010
                        T L+E L+ EK V  E++  +       E  LK   +   +LE   +E
Sbjct: 3128 MQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLE 3187

Query: 1011 VEKEKQELQDDKRRAIESMEQQL-SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQ 1069
            V+        DK   +  +   L SE KK+      E+Q AL++    L   ++  ++  
Sbjct: 3188 VK--------DKTDEVHLLNDTLASEQKKS-----RELQWALEKEKAKLGRSEERDKEEL 3234

Query: 1070 EQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
            E  K ++E+Q   +R L L+    +  Q   E   K+ S R   +    + + + LE + 
Sbjct: 3235 EDLKFSLESQK--QRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292

Query: 1130 SWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEE 1189
              E  E++   E+S  + R        R LH Q++  SD           G     L  E
Sbjct: 3293 LLES-EKVRIREMSSTLDR-------ERELHAQLQS-SDGT---------GQSRPPLPSE 3334

Query: 1190 GKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKV 1249
                    ++L+ ++++ E   +R      E+ +Y+         L  LQ     E+++ 
Sbjct: 3335 --------DLLKELQKQLEEKHSRIVELLNETEKYK---------LDSLQTRQQMEKDR- 3376

Query: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE 1309
            QV  KT+   +E    TE    + E    L+ + E L++ L++ + +V KL+L+   LQ 
Sbjct: 3377 QVHRKTLQTEQE--ANTEGQKKMHE----LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430

Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
                      M + +K+ LE + KR   R   L     +P T       +   V  ++I+
Sbjct: 3431 I---------MQEFQKQELEREEKRESRR--ILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3479

Query: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL----------DA 1419
              T+E     A++   N   T   + ++ +++ L  V ++ + + +            D 
Sbjct: 3480 GETKESN--YAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDE 3537

Query: 1420 KIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQEL 1479
              I +QE +  I            Q ++L  QQ +     + S+         +++  EL
Sbjct: 3538 DFIWVQENIDEII----------LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAEL 3587

Query: 1480 KETLNQAETKSKSLESQVENLQKTL 1504
               ++Q   +   L + V  L++ +
Sbjct: 3588 TGHISQLTEEKNDLRNMVMKLEEQI 3612



 Score =  135 bits (340), Expect = 5e-31
 Identities = 212/1010 (20%), Positives = 425/1010 (42%), Gaps = 145/1010 (14%)

Query: 745  RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE----VRLSQ 800
            R ++        EQ        L     +LA  +   E L +E E ++++     ++  Q
Sbjct: 135  REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ 194

Query: 801  QRESLLAEQRGQNLLLT-NLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858
            + E+ + ++ G    LT NLQ  Q   E+ ET  +   L+ Q +KL+ +   L+   E  
Sbjct: 195  EFEAAIKQRDGIITQLTANLQ--QARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251

Query: 859  VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
                H+ T      LL  K+Q+ T          LL++ QK+       +S ++ ++   
Sbjct: 252  RNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308

Query: 919  SSQRTGKGQPSNKED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT- 970
              ++  K + SNKE+       +++L +++ + E++  +LK++L T+   + + Q  +  
Sbjct: 309  EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQ 368

Query: 971  ----------SLEESLNKEKQVTEEVR------KNIEVRLKESAEFQTQLEKKL-----M 1009
                       L  S  KE+Q +EE++      + ++ R  + ++F+T + +++      
Sbjct: 369  KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR 428

Query: 1010 EVEKEKQELQDDKRRAIESMEQQL-----SELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
            ++E+ + EL +   + I  M+Q+L     +++++  +  + E++ AL+  S    NE Q 
Sbjct: 429  KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488

Query: 1065 R--RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
            +       +  I ++  N  + +L       E L    E+   +    + L E    +  
Sbjct: 489  KLMNVAINELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSRE 542

Query: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK------E 1176
            Q+   + +  E+E  L +E  K +   EDL+ +     +  ++L  K  A V       E
Sbjct: 543  QIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601

Query: 1177 GVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIA--------ETRFEVAQVE---SL 1222
             ++   N  L    +SQE  LE LR       E+E++        E R  + +++    +
Sbjct: 602  MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661

Query: 1223 RYRQRVELLERELQELQDSLNAEREK---------VQVTAKTMAQHEELMKKTETMNVVM 1273
             Y+Q+++ L+ E+ +  +++  E++          ++++     Q   +  K+E M + +
Sbjct: 662  HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721

Query: 1274 -----ETNKMLREEKER--LEQDLQQMQAKVRKLELDIL----PLQEANAELSEKSGMLQ 1322
                 E   + +EEKE+  LEQ++Q++Q K   LE  +      LQE  A+L  ++ +L+
Sbjct: 722  NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781

Query: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
             EKK LE+ +K         VSQ++     +  K  S+  V  K I+ L EE   LK   
Sbjct: 782  DEKKTLEDMLKIHTP-----VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK--- 833

Query: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
                      Q  IQ L E++ K R      +K+ +    ++QE+   + +VK      K
Sbjct: 834  ----------QQCIQ-LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882

Query: 1443 TQYE-----ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497
             + E     +LKA  +++       +    +  V  ++   + ETL   E   K     +
Sbjct: 883  NKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942

Query: 1498 ENLQKTLSEK---ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
            E L+ T  EK        +L EQ  Q   E+S L ++++    ++EQ+  +  E E    
Sbjct: 943  EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---- 998

Query: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614
              I+   ++  ++     Q++                   LD  +T      EG +S++ 
Sbjct: 999  --IIINHNRAENVQSCDTQVS-----------------SLLDGVVTMTSRGAEGSVSKVN 1039

Query: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDP 1664
            +   E  +  +E +   +  +     +Q Q+ L   P+  +      + P
Sbjct: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 221/1156 (19%), Positives = 459/1156 (39%), Gaps = 180/1156 (15%)

Query: 44   EKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN---KELE 100
            EK  +E E++  E++K L  ++++   + ++     +E+ K   +L    E++    ELE
Sbjct: 2625 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELE 2684

Query: 101  IAQDRNIAIQSQFTRTKEELEAEKRDLI--RTN-----ERLSQELEYLTEDVKRLNEKLK 153
              +  ++A +++    KE+ E  + +L+   TN     + LSQ  ++L E  ++L+   K
Sbjct: 2685 ALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEK 2744

Query: 154  ESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
            E  T          E+Q S  +  +    ++  K +    +  L      +T ++L   +
Sbjct: 2745 EDET----------EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV--K 2792

Query: 214  EKGNEI-LELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
              G +I L+ +C+ E   E +S+  E++  ++      + H  ++L    + + +  S  
Sbjct: 2793 NAGIQINLQSECSSEEVTEIISQFTEKIEKMQ------ELHAAEIL----DMESRHISET 2842

Query: 273  EKFHNELNAHIKLSNLYKSAADDSEA-----KSNELTRAVEELHKLLKEAGEANKAI--- 324
            E    E   H     L K      +A     +S E +   E  H    +  E   +    
Sbjct: 2843 ETLKRE---HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGS 2899

Query: 325  ---QDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND--------LLSATKRKGA-ILSE 372
               Q   L   Q  D      +   GR E E E+A D        LL A   +G  +LS 
Sbjct: 2900 DWGQGIYLTHSQGFD------IASEGRGE-ESESATDSFPKKIKGLLRAVHNEGMQVLSL 2952

Query: 373  EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL--LLEKLENKRINKYLDEIVKEV 430
             E         ++ ++ +P +   E   AY+ T   L  L+ K++ +R            
Sbjct: 2953 TESPYSDGEDHSIQQVSEPWL---EERKAYINTISSLKDLITKMQLQR------------ 2997

Query: 431  EAKAPILKRQREEYE--RAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRR 488
            EA+     +  E +   R +  +A   V LE+    +   + +        +V   +   
Sbjct: 2998 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLE 3057

Query: 489  MEIQVKDLSQQIRVLLME-------LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541
              IQ + +  Q  +  ++       L E +  H   +    +      SE  SQ L+ Y 
Sbjct: 3058 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEY- 3116

Query: 542  NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE---QLRKSRQ 598
            NI++ Q Q   + V L  + +     +++ +S K+   +LK E A T+LE    L+   +
Sbjct: 3117 NIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK 3176

Query: 599  HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVP 658
            H  +L        + +R+ +   T           D+V L                    
Sbjct: 3177 HLKEL--------EAFRLEVKDKT-----------DEVHL-------------------- 3197

Query: 659  VIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
             +  T A E K + ++LQ   E  K +   +E+   E+LE L+  +   + +N +++  L
Sbjct: 3198 -LNDTLASEQKKS-RELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLL 3255

Query: 719  DFASKRYEMLQDNVEG----YRREITSLHERNQKLTATTQKQEQIINTMTQDL---RGAN 771
            +   +     Q  +E     Y  +++    RN +L    + ++  I  M+  L   R  +
Sbjct: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315

Query: 772  EKLAVAEVRAENLK--KEKEMLKLSEVRLSQQRESLLAE--QRGQNLLLTNLQTIQGI-- 825
             +L  ++   ++      +++LK  + +L +++ S + E     +   L +LQT Q +  
Sbjct: 3316 AQLQSSDGTGQSRPPLPSEDLLKELQKQL-EEKHSRIVELLNETEKYKLDSLQTRQQMEK 3374

Query: 826  ---LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQ------LLDT 876
               + R   +T+Q  +++ +K  HE+    + L+ ++E++      LD++      ++  
Sbjct: 3375 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQE 3434

Query: 877  KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
             ++ + E      ++ +L     E  T           V  Q  +  G+ + SN   + +
Sbjct: 3435 FQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIE 3492

Query: 937  LVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE---VRKNIEVR 993
            +         ++  ++++L+   S +   Q +     E L  E    E+   V++NI+  
Sbjct: 3493 MNGGGTGCNHELEMIRQKLQCVASKL---QVLPQKASERLQFETADDEDFIWVQENID-- 3547

Query: 994  LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
                 E   QL+ KL   + E+  L           E+ L +  +    +    +E    
Sbjct: 3548 -----EIILQLQ-KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDL 3601

Query: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHL 1113
             +  +  E+Q R   Q  A      ++   R  +   A++EA+ A++++V     +   L
Sbjct: 3602 RNMVMKLEEQIRWYRQTGA-----GRDNSSRFSLNGGANIEAIIASEKEVWNREKLT--L 3654

Query: 1114 EETTQKAESQLLECKA 1129
            +++ ++AE+++ + KA
Sbjct: 3655 QKSLKRAEAEVYKLKA 3670



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 121/629 (19%), Positives = 248/629 (39%), Gaps = 74/629 (11%)

Query: 11   RTELNKLPKS----VQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE 66
            RTEL  L  +    + N LE+ + +Q  E        +K   +      EI+   +    
Sbjct: 3038 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSEIQALHAQMNG 3095

Query: 67   RLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRD 126
            R +   RE +S +   E L   ++    +  E+++      +++ + T  +E+L +EK  
Sbjct: 3096 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS---SMKDRATELQEQLSSEKMV 3152

Query: 127  LIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE 186
            +      L+Q    L   +K  ++ LKE    + E++ K DE                  
Sbjct: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE------------------ 3194

Query: 187  KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTS 246
               +H  N  L +E K   +   AL +EK     +L  + E  KEE+  L+  +   K  
Sbjct: 3195 ---VHLLNDTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFSLESQKQR 3247

Query: 247  NEHLQKHVEDLLTKLKEAKE----QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
            N  L   +E     L E+++    Q+   + +   E   +++L  L +S        S+ 
Sbjct: 3248 NLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSST 3307

Query: 303  LTRAVEELHKLLKEA---GEANKAI--QDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
            L R   ELH  L+ +   G++   +  +D L E+++  ++    ++E +   EK   ++ 
Sbjct: 3308 LDRE-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSL 3366

Query: 358  DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK 417
                  ++   +  +              K+ +   K+ +L     E + Q+    LE +
Sbjct: 3367 QTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQ 3426

Query: 418  RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA-SLSVKLEQAMKEIQRLQEDTDKAN 476
            R+   + E  K+   +    + +R  Y+   +    SL+    +     Q+++ +T ++N
Sbjct: 3427 RLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESN 3486

Query: 477  KQSSVLERD------NRRMEI---QVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADIS 527
              + ++E +      N  +E+   +++ ++ +++VL  +  E        DE+       
Sbjct: 3487 -YAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDED------- 3538

Query: 528  SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESAL 587
                     +    NI+E+  Q Q+L     + GE        T+   +TE  L+  + L
Sbjct: 3539 --------FIWVQENIDEIILQLQKL---TGQQGEEPSLVSPSTSCGSLTERLLRQNAEL 3587

Query: 588  T-ELEQLRKSRQHQMQLVDSIVRQRDMYR 615
            T  + QL + +     +V  +  Q   YR
Sbjct: 3588 TGHISQLTEEKNDLRNMVMKLEEQIRWYR 3616


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score =  182 bits (462), Expect = 3e-45
 Identities = 381/1857 (20%), Positives = 779/1857 (41%), Gaps = 315/1857 (16%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGR---HEKFKVESEQQYFEIEKRL 61
            LQ+ ++  E+ +  K V+N  ++ + ++++ I+ L  +    EK  +E + +    +K L
Sbjct: 301  LQEKIKVYEMEQ-DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359

Query: 62   SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRNIA--------- 108
               QE++V + +E ++++LEL     + +  +E+ K+L    E  Q RN           
Sbjct: 360  GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419

Query: 109  --IQSQFTRTKEELEAE------------KRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154
              ++ +  R  E+L AE            K++LIR  + ++Q  E  T     +   L+ 
Sbjct: 420  QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGEMENALRS 477

Query: 155  -SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
             SN T  E Q+KL  +  +++++K ++   ++EK         L  EL    +E  AL R
Sbjct: 478  YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK---------LKEELGLILEEKCALQR 528

Query: 214  EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273
            +  + + EL  + E  +     + EQ + L  +++ L   VEDL  ++  A E +  +E 
Sbjct: 529  QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VEDLKAEIVSASESRKELEL 587

Query: 274  KFHNEL-NAHIKLSNLYK--SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD---- 326
            K   E+ N  IKL  L K  +A  D  A+S E          L     E +K  +D    
Sbjct: 588  KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647

Query: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386
            H + +E+ KD +     ++I  L+ E+    + +   K        + +  +S       
Sbjct: 648  HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS------- 700

Query: 387  KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446
                   KL +L  + V ++ +          +   ++E+ KE+E    IL+++ +E   
Sbjct: 701  -------KLKDLQQSLVNSKSE---------EMTLQINELQKEIE----ILRQEEKEKGT 740

Query: 447  AQKAVASLSVK---LEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVK---DLSQQ 499
             ++ V  L +K   LE+ MKE +  LQE   +   ++S+L+ + + +E  +K    +SQ+
Sbjct: 741  LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800

Query: 500  IRVLLMELEEARGNHVIRDEEVS-----SADISSSSEVISQHLVSYRNI----------- 543
             R++ ++  +++    + ++E+      + D+      +++ +   RN            
Sbjct: 801  ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860

Query: 544  -EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
             +ELQ++   LL    +L +++ ++E E  S        KL+ AL E   L++     ++
Sbjct: 861  YQELQEEYACLLKVKDDLEDSKNKQELEYKS--------KLK-ALNEELHLQRINPTTVK 911

Query: 603  LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
            +  S+  + D   +  +   G  +    + L +    +  ++   SQ +S        + 
Sbjct: 912  MKSSVFDE-DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS--------DL 962

Query: 663  TEAIEAK-AALKQLQEIFENYKKEKAENEKIQNEQLEKL--QEQVTDLRSQNTKISTQLD 719
            +E ++ K   +  L E  ++ K+EK E   ++  +LE +    +  +++S +T++S+ LD
Sbjct: 963  SEQLKQKHGEISFLNEEVKSLKQEK-EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021

Query: 720  FASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ------------KQEQIINTMTQDL 767
                   M     EG   ++        K+    +            KQEQ+I      +
Sbjct: 1022 GV---VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078

Query: 768  RGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT--IQGI 825
               +   A      + L+KE  +LK  +  L  Q E+       Q + L+ + +  +  +
Sbjct: 1079 TKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-------QRICLSLVYSTHVDQV 1131

Query: 826  LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
             E  E E  + L S    L+ E+   +++   E+++ H     L++Q + T+   D    
Sbjct: 1132 REYMENEKDKALCS----LKEELIFAQEEKIKELQKIH----QLELQTMKTQETGDEGKP 1183

Query: 886  LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
            LHL   +L K   +E +   Q L ++  +  + + +     +  +KE+  D +S+    E
Sbjct: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE--DKENSGDYISENEDPE 1241

Query: 946  EQ-----VNDLKERLKTSTSNV-EQYQAMV---TSL----------------EESLNKEK 980
             Q     V D +E + T  + V E+Y  ++   T L                EE+L KE+
Sbjct: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301

Query: 981  --------QVT--EEVRKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRAIESM 1029
                    Q+T  E++  N + +L    + + T+LE+++ E+E     LQ   +   ++ 
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361

Query: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC--------------------- 1068
            E ++  L+K L +V            + +  E  A+R                       
Sbjct: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421

Query: 1069 -QEQAKIAVEAQNKYERELMLHAADV-EALQAAKEQVSKMASVRQHLEETTQKAESQLL- 1125
             +E+  I    + +Y+ +L    A V  ++  A  Q ++++ +    E T    ++  + 
Sbjct: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC 1481

Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLE--KQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183
            + +  +    ++ +D++        D++  ++ + L  ++ +   +++ S  +    P +
Sbjct: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES 1541

Query: 1184 ----VSLSEEGKSQEQILEILRFIRREKEIA------ETRFEVAQVESLR---------Y 1224
                +++SEE  S+++   + + I  E  ++      +      Q+E +R         +
Sbjct: 1542 KDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEH 1601

Query: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
            +Q  ELL +      +    ++E++Q   K + +        +  N+V E  ++L EE E
Sbjct: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELE 1661

Query: 1285 RLEQ-DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL--LEEDVKRWKARNQH 1341
             L+Q  L   +    +L       Q  N    E       EK+L    EDV      N+ 
Sbjct: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721

Query: 1342 LVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL------KAEIARSNASLTNNQNL 1395
               Q+ +       K+L E    T  ++   E IGR       ++  ++S+ASL      
Sbjct: 1722 YALQKAN---NRLLKILLEVVKTTAAVE---ETIGRHVLGILDRSSKSQSSASLIWRSEA 1775

Query: 1396 IQSLKEDLNK--VRTEKETIQK----DLDAKIIDIQEKV--------KTITQVKKIGRRY 1441
              S+K  +++   R   E+I      D+    I++  KV        + + +    G   
Sbjct: 1776 EASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI 1835

Query: 1442 KTQYEEL--------KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493
              + EEL        +A  +K++E  +++S   Q +H  V + + ++E+  Q +  ++SL
Sbjct: 1836 DPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATESL 1893

Query: 1494 ESQVENLQKTLSEKE--------------------TEARNLQEQTVQLQSEL-SRLRQDL 1532
            + Q E L++ L E+                      + + L E+ +Q ++++  RL Q+L
Sbjct: 1894 KCQ-EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952

Query: 1533 ---QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589
                +R  + E  +QQI E+ E   +   A K   A    V+ QL +E E+L +    + 
Sbjct: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMK---AEAGPVEQQLLQETEKLMKEKLEVQ 2009

Query: 1590 QQ----KDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQ 1642
             Q    +D+L  ++ AL+   E ++SR    +   QE++ E  D  Q+  N+  E+Q
Sbjct: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDLRQQ--NQALEKQ 2061



 Score =  177 bits (450), Expect = 8e-44
 Identities = 358/1779 (20%), Positives = 756/1779 (42%), Gaps = 272/1779 (15%)

Query: 6    QQVLERTEL-NKLPKSV---QNKLEKFLADQQS---EIDGLKGRHEKFKVESEQQYFEIE 58
            +Q+ E+T++ ++L + +    N+L++  A+QQ    E + L  + E  K E+      +E
Sbjct: 1936 RQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP----VE 1991

Query: 59   KRLSHSQERLVNETRE--CQSLRLELEKLNNQLKALT---------------EKNKELEI 101
            ++L    E+L+ E  E  CQ+ ++  + L  Q+KAL                EKN EL  
Sbjct: 1992 QQLLQETEKLMKEKLEVQCQAEKVR-DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050

Query: 102  AQDRNIAIQSQFTRTKEELEAE------KRDLIRTN-ERLSQEL----------EYLTED 144
             + +N A++ Q  + ++ L+ +      +RD+ +   ++L Q+L          E+ T +
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110

Query: 145  VKRLNEKLKESNTTKGELQLKLDELQASDVS--------VKYREKRLEQEKELLHSQNTW 196
            V++L   LKE      EL L  ++LQ  D+         +++R + LEQ   LL S +T+
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQR-DIQERNEEIEKLEFRVRELEQ--ALLVSADTF 2167

Query: 197  LNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVED 256
                   K ++    G  +    L L+  L+ +++ + R E+++  L+   E L++  E+
Sbjct: 2168 ------QKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLE---EQLEQFREE 2218

Query: 257  LLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----AKSNELTRAVEELHK 312
            L  K +E ++    +E +         +L    K   DD E    A       + ++ H 
Sbjct: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278

Query: 313  LLKEAGEANKAIQDHLLEVEQSKDQMEK-EMLEKIGRLEKELENANDLLSATKRKGAILS 371
            L    G+  + IQ+  +E++Q  +Q+ K +   KI    K +E  N+L+   + +   L 
Sbjct: 2279 LF---GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLM 2335

Query: 372  EEELAAMSPTAAAVAKIVKPGMKL-TELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
             ++          + ++ +   KL  EL N   +T         E   +   LD ++ E 
Sbjct: 2336 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK 2395

Query: 431  EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--------- 481
             A    ++   EE    +  +   + K+ Q  +E+  L+ + +   K  S+         
Sbjct: 2396 LALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2455

Query: 482  --LERDNRRMEI-----QVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVIS 534
              L +D   +E+      +K L  Q      E E  +G+ +  +  +   + + S++ + 
Sbjct: 2456 DHLSKDKPELEVVLTEDALKSLENQTYFKSFE-ENGKGSIINLETRLLQLESTVSAKDL- 2513

Query: 535  QHLVSYRNIEELQQQNQ-RLLVALRELGETREREEQETTSSKITELQLKLESALTELEQL 593
            +    Y+ I+++Q+Q Q    +  +++   ++  E++  ++ ++++QL+      +  Q 
Sbjct: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ- 2572

Query: 594  RKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVST 653
                    Q + S   + ++  +   +   +   + A +L    L S      TS  +  
Sbjct: 2573 ------DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS-LILE 2625

Query: 654  PAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTK 713
               V + E    +E +  L +LQ++ E  +K++ E EK ++ Q  ++ +  T+L   N +
Sbjct: 2626 KEQVEIAEK-NVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684

Query: 714  ISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEK 773
                 +  + R E +       + E+ S  E+ +KL      +E  + ++ +DL    + 
Sbjct: 2685 SGFFNELEALRAESV-----ATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH 2739

Query: 774  LAVAEVRAENLKKEKE----------MLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQ 823
            LA A+ +   L+KE E          M +   ++LS   +S+ ++  G   + ++ QT Q
Sbjct: 2740 LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS---KSIASQTDGTLKISSSNQTPQ 2796

Query: 824  GILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE 883
             +++ +  +   +     E++   IS   +K+E ++++ H      ++  ++++   +TE
Sbjct: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIE-KMQELHA----AEILDMESRHISETE 2851

Query: 884  T--NLHLNTKELLKNAQKEIATLKQHLSNMEVQ----------------VASQSSQRTGK 925
            T    H    +LLK     +  + Q L + E                   +S S    G+
Sbjct: 2852 TLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911

Query: 926  GQPSNKEDVDDLVSQLR--QTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKE---- 979
            G         D+ S+ R  ++E   +   +++K     V      V SL ES   +    
Sbjct: 2912 GIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2971

Query: 980  --KQVTE---EVRK---NIEVRLKE-SAEFQTQLEKKLMEVEKEKQELQDDKRRAIESME 1030
              +QV+E   E RK   N    LK+   + Q Q E ++ +  +  +   D +   + +++
Sbjct: 2972 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3031

Query: 1031 QQ-LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA---KIAVEAQNKYEREL 1086
            Q  L E    L++ + E+       +  L N  + R   QEQ    + A+E   K +R  
Sbjct: 3032 QVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQR--IQEQGVEYQAAMECLQKADRRS 3089

Query: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
            +L  ++++AL A  +   +  ++++  E+ ++K   +LLE                    
Sbjct: 3090 LL--SEIQALHA--QMNGRKITLKR--EQESEKPSQELLEYNIQ---------------- 3127

Query: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE 1206
                  +KQ+++L  Q+E      ++S+K+         L E+  S++ ++  L+     
Sbjct: 3128 ------QKQSQMLEMQVE------LSSMKDRA-----TELQEQLSSEKMVVAELK----- 3165

Query: 1207 KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT 1266
             E+A+T+ E+      +++       +EL+  +  +  + ++V +   T+A  +   KK+
Sbjct: 3166 SELAQTKLELETTLKAQHKHL-----KELEAFRLEVKDKTDEVHLLNDTLASEQ---KKS 3217

Query: 1267 ETMNVVMETNK-MLREEKERLEQDLQQMQ-----AKVRKLELDILPLQEANAELSEKSGM 1320
              +   +E  K  L   +ER +++L+ ++      K R L+L++L L++    L+E    
Sbjct: 3218 RELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL-LEQQKQLLNESQQK 3276

Query: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA 1380
            +++++ L +  +   + RN             E + LL  ++V   RI++++  + R + 
Sbjct: 3277 IESQRMLYDAQLSEEQGRNL------------ELQVLLESEKV---RIREMSSTLDRERE 3321

Query: 1381 EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR 1440
              A+  +S    Q+      EDL K       +QK L       +EK   I ++     +
Sbjct: 3322 LHAQLQSSDGTGQSRPPLPSEDLLK------ELQKQL-------EEKHSRIVELLNETEK 3368

Query: 1441 YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
            YK    + + Q +K             ++ V  + +Q  +E   + + K   L+S+VE+L
Sbjct: 3369 YKLDSLQTRQQMEK-------------DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL 3415

Query: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560
            Q+ L EK  +   L  +  +LQ  +   ++   +R  + E  R       E T  ++ + 
Sbjct: 3416 QRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3475

Query: 1561 KSKIAHLAGVKDQLTKENE--ELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELR 1618
            +++   L    +  TKE+   +L + NG       EL++    ++ + +   S+L+   +
Sbjct: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM----IRQKLQCVASKLQVLPQ 3531

Query: 1619 EHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
            +  ER L+      E    V E   +I L+    +G++G
Sbjct: 3532 KASER-LQFETADDEDFIWVQENIDEIILQLQKLTGQQG 3569



 Score =  158 bits (400), Expect = 5e-38
 Identities = 346/1824 (18%), Positives = 740/1824 (40%), Gaps = 286/1824 (15%)

Query: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
            + +L  L K     L++    Q++E++ L+           Q  F  E+ LS  +E L  
Sbjct: 597  KIKLEMLEKEKNAVLDRMAESQEAELERLR----------TQLLFSHEEELSKLKEDLEI 646

Query: 71   ETRECQSLRLELEKLNNQL------------KALTEKNKELEIAQDRNIAIQSQFTRTKE 118
            E R      + +EKL + L              +++K + ++  +D  I  Q+Q      
Sbjct: 647  EHR------INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700

Query: 119  ELEAEKRDLIRT-NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
            +L+  ++ L+ + +E ++ ++  L ++++ L ++ KE  T + E+Q    + +  +  +K
Sbjct: 701  KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK 760

Query: 178  YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237
             +E  L+++   L ++N+ L  E KT  D L         E L    ++++K ++ S  E
Sbjct: 761  EKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD-SVWE 819

Query: 238  EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF---HNELNAHIKLSNLYKSAAD 294
            +++  L   NE L++    L  ++++ +   +  E+ F   + EL          K   +
Sbjct: 820  KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE 879

Query: 295  DSEAKS-----NELTRAVEELH---------KLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
            DS+ K      ++L    EELH         K+     + +K      LE+ +  ++   
Sbjct: 880  DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939

Query: 341  EMLEKIGRLEKEL----ENANDLLSATKRKGAILS--EEELAAMSPTAAAVA------KI 388
            E++EK+   ++E     +  +DL    K+K   +S   EE+ ++      V+      +I
Sbjct: 940  ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEI 999

Query: 389  VKPGMKLTELYNAYVETQDQLLLEKLEN----------KRINKYLDEIVK-EVEAKAPIL 437
            +    +   + +   +TQ   LL+ +             ++NK   E  K  VE K    
Sbjct: 1000 IINHNRAENVQSC--DTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057

Query: 438  KRQREEYERAQKAVASL--SVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKD 495
                 E  + ++ +     SV  E +++  Q    + DK  K+ +VL+ +   + +Q++ 
Sbjct: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQ--PSENDKLQKELNVLKSEQNDLRLQME- 1114

Query: 496  LSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVI---SQHLVSYRNIEELQQQNQR 552
             +Q+I + L+            + E   A  S   E+I    + +   + I +L+ Q  +
Sbjct: 1115 -AQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMK 1173

Query: 553  ------------LLVALRELGETRE-------------------------REEQETTSSK 575
                        LL+   +   + E                          E++E +   
Sbjct: 1174 TQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDY 1233

Query: 576  ITELQ-LKLESALTELEQLRKSRQHQMQLVDS-----IVRQRDMYRILLSQTTGVAIPLH 629
            I+E +  +L+    E++  +++    +  V       +V Q  + +I   QT G+ +   
Sbjct: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG 1293

Query: 630  ASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAEN 689
              +L        PK                 E TE +   + +  L++I  N+K + +  
Sbjct: 1294 EENL--------PK-----------------EETEFLSIHSQMTNLEDIDVNHKSKLSS- 1327

Query: 690  EKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKL 749
              +Q+ +  KL+EQV +L S  + +  QL          ++  + Y  EI  L +R Q +
Sbjct: 1328 --LQDLEKTKLEEQVQELESLISSLQQQL----------KETEQNYEAEIHCLQKRLQAV 1375

Query: 750  TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL------------KKEKEMLKLSEVR 797
            + +T      ++++      A   +       +N+            K+E  ++KL E +
Sbjct: 1376 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ 1435

Query: 798  LSQQRESLLAEQRGQNLLL----TNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
              +Q E  +A+      +     T L  I G   +  T + ++  +  ++ +H  + +K 
Sbjct: 1436 YQEQLEEEVAKVIVSMSIAFAQQTELSRISG--GKENTASSKQAHAVCQQEQHYFNEMKL 1493

Query: 854  KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
              +    Q       +DV+  +  + L  E   H     L  +   +I   K  +  +  
Sbjct: 1494 SQDQIGFQTF---ETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550

Query: 914  QVASQSSQRTGKGQPSNKEDVD--DLVSQLRQTEEQVNDLKERLKTSTSNVEQY-----Q 966
            ++ S+      +    ++  V   D   QL   EEQ+ D+++ L       +Q      Q
Sbjct: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610

Query: 967  AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK---QELQDDKR 1023
            A +  +E     ++Q+ EE++     RL      ++ ++ + +  E+E+   +EL+  K+
Sbjct: 1611 AHMRQMERQREDQEQLQEEIK-----RLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665

Query: 1024 RAIESMEQQLSELKKTLSSVQN------EVQEALQRASTALSNEQQARRDCQEQAKIAVE 1077
             ++   E+   EL+ + +  QN      EV+E   +        +    +     + A++
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQ 1725

Query: 1078 AQNKYERELMLHAADVEALQAAKEQVSK-------MASVRQHLEETTQKAESQLLECKAS 1130
              N    +++L    V+   A +E + +        +S  Q       ++E++       
Sbjct: 1726 KANNRLLKILLEV--VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCV 1783

Query: 1131 WEERERMLKDEV---SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ-GPLNVSL 1186
             EE  R+  + +   S       D+   +++  +  E LS ++V S   G +  P N  L
Sbjct: 1784 HEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDPENEEL 1842

Query: 1187 SEEGKSQ-----EQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDS 1241
                 S+     E++LE +     + E A+        ES R +Q      +  +EL++ 
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902

Query: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE---RLEQDLQQMQAKVR 1298
            L+ E    +  A  +++ E ++        + E  + ++E+ +   RLEQ+L     +++
Sbjct: 1903 LHEESRAREQLAVELSKAEGVIDGYADEKTLFE--RQIQEKTDIIDRLEQELLCASNRLQ 1960

Query: 1299 KLELDILPLQEANAELSEKSGMLQAE-----KKLLEEDVKRWKARNQHLVSQQKDPDT-- 1351
            +LE +   +QE    LS +   ++AE     ++LL+E  K  K + +     +K  D   
Sbjct: 1961 ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ 2020

Query: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE 1411
            ++ + L  + E    R  +L +E      ++ + N +L   +  ++ +++ L++   ++E
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL---EKQLEKMRKFLDEQAIDRE 2077

Query: 1412 TIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEEL----KAQQDKVME---TSAQSSG 1464
              +     +I  +++++K + + + I      + E+L    K + DK  E   +  Q   
Sbjct: 2078 HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137

Query: 1465 DHQEQHVSVQEMQELKETLNQA--------------------ETKSK-SLESQVENLQKT 1503
            D QE++  +++++     L QA                    E K + SLE Q++  +  
Sbjct: 2138 DIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDA 2197

Query: 1504 LSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAK 1561
            +  KE E  NL+EQ       L + R++L+++  + +QL  Q  I +KE  TR   +  +
Sbjct: 2198 IDRKEKEITNLEEQ-------LEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2250

Query: 1562 SKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQ 1621
            +K+      KD + K    +K+ +    Q +  L  +   +  + E  I +L  ++ + Q
Sbjct: 2251 NKL-----FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2305

Query: 1622 ERHLEQRDEPQEPSNKVPEQQRQI 1645
            ++     D      NKV E++ ++
Sbjct: 2306 QQLKITTD------NKVIEEKNEL 2323



 Score =  150 bits (379), Expect = 1e-35
 Identities = 340/1665 (20%), Positives = 678/1665 (40%), Gaps = 213/1665 (12%)

Query: 8    VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
            V  +++L+ L    + KLE+ + + +S I  L+ + ++ +   E +   ++KRL    E 
Sbjct: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378

Query: 68   LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
             V  +    S+ +        +   +   K +    D  I    +F   KEE    K   
Sbjct: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNI----DGTIEFSGEF-GVKEETNIVKLLE 1433

Query: 128  IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
             +  E+L +E+  +   +     +  E +   G  +      QA   +V  +E+    E 
Sbjct: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--AVCQQEQHYFNEM 1491

Query: 188  ELLHSQ---NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
            +L   Q    T+   ++K K +E   L +E G          E+ KE +         L 
Sbjct: 1492 KLSQDQIGFQTFETVDVKFK-EEFKPLSKELG----------EHGKEIL---------LS 1531

Query: 245  TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
             S+ H     +D +  +    E+  S ++ F    + H ++S     A+        +L 
Sbjct: 1532 NSDPHDIPESKDCVLTI---SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLE 1588

Query: 305  RAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS-- 361
               +EL +  +E  +A + + Q H+ ++E+ ++  E ++ E+I RL ++L   + + +  
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLAQRSSIDNEN 1647

Query: 362  -ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
              ++R+  +L E E       A       +     T+  N   E Q ++  +  + K ++
Sbjct: 1648 LVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEEQTFKEKELD 1706

Query: 421  KYLDEIVKEVEAKAPILKRQREEYERAQKAVASL---SVKLEQAMKE-----IQRLQEDT 472
            +  +++  E      IL  +R   ++A   +  +    VK   A++E     +  + + +
Sbjct: 1707 RKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760

Query: 473  DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532
             K+   +S++ R      ++     +  RV    +    G+ + R++    + ++     
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820

Query: 533  ISQHLV---------SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583
            +SQ LV            N E +   + RL  A+ +L E       +   +K+T+ +L  
Sbjct: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880

Query: 584  ES--ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
            ES     E  +  K ++   + +    R R+   + LS+  GV         D+ +L   
Sbjct: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGYADEKTLFER 1936

Query: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE----KAENEKIQNEQL 697
              +  T   +       +  S    E +A  +Q+QE  E   ++    KAE   ++ + L
Sbjct: 1937 QIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995

Query: 698  ---EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
               EKL ++  +++ Q  K+   L    K  E+  D  E   R I    E+N +L    Q
Sbjct: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI--DVEEQVSRFIELEQEKNTELMDLRQ 2053

Query: 755  KQEQIINTMTQDLRGANEKLAV-----AEVRAENLKKEKEMLKL---------SEVRLSQ 800
             Q Q +    + +R   ++ A+      +V  + ++K ++ LK+          + R  +
Sbjct: 2054 -QNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVE 2112

Query: 801  QRESLLAEQ--RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENE 858
            Q  + L E+  +   LLL+  Q  + I ER+E         +IEKLE  +  L++ L   
Sbjct: 2113 QLANHLKEKTDKCSELLLSKEQLQRDIQERNE---------EIEKLEFRVRELEQALLVS 2163

Query: 859  VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVA 916
             +    +        ++ K +L  E  L    ++ +   +KEI  L++ L     E++  
Sbjct: 2164 ADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-RDAIDRKEKEITNLEEQLEQFREELENK 2222

Query: 917  SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
            ++  Q+        K++    + +L Q  +   D  E+L  +   +++  AM T  +  L
Sbjct: 2223 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMSTQDQHVL 2279

Query: 977  -NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL-MEVEKEKQELQDDKRRAIESM----- 1029
              K  Q+ +E    I+   ++  + Q QL+     +V +EK EL  D    IE +     
Sbjct: 2280 FGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE 2339

Query: 1030 ------EQQLSELKKTLSSVQNEVQEALQRAST---ALSNEQQARR---DCQEQAKIAVE 1077
                  E+++ +L + +  +Q E+    Q+ S    +LS E  + +   D     K+A+E
Sbjct: 2340 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399

Query: 1078 AQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
             Q +   E M    +V      KE   KM  + Q L    ++ ES + + ++  E    +
Sbjct: 2400 QQVETANEEMTFMKNV-----LKETNFKMNQLTQELFSLKRERES-VEKIQSIPENSVNV 2453

Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV-VASVKEGVQGP-LNVS---LSEEGKS 1192
              D +SK     +  E +  L  D ++ L ++    S +E  +G  +N+    L  E   
Sbjct: 2454 AIDHLSK-----DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV 2508

Query: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSL---NAEREKV 1249
              + LE+ +  ++ K++ E      Q E+   ++++  L++ ++E   +      + E V
Sbjct: 2509 SAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2564

Query: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI----- 1304
            Q  AK    ++ +  + E  N+  +    LRE++  L  D+  +  ++ +LE  +     
Sbjct: 2565 QEYAKFCQDNQTISSEPERTNI--QNLNQLREDE--LGSDISALTLRISELESQVVEMHT 2620

Query: 1305 -LPLQEANAELSEKSGMLQAEKKLLE-EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE 1362
             L L++   E++EK+ +L+ EKKLLE + +     + Q    +++ P   E  K  +E  
Sbjct: 2621 SLILEKEQVEIAEKN-VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL- 2678

Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
             H+        E+  L+AE   + A L + +   + L+E+L    T   ++QKDL     
Sbjct: 2679 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDL----- 2733

Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
                     +QV+                 D + E   + S   +E    VQE ++    
Sbjct: 2734 ---------SQVR-----------------DHLAEAKEKLSILEKEDETEVQESKKACMF 2767

Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEE-- 1540
                   SKS+ SQ +   K  S           QT Q+  + + ++ +LQ   + EE  
Sbjct: 2768 EPLPIKLSKSIASQTDGTLKISS---------SNQTPQILVKNAGIQINLQSECSSEEVT 2818

Query: 1541 QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN 1585
            ++  Q TEK EK ++         A +  ++ +   E E LK+ +
Sbjct: 2819 EIISQFTEKIEKMQEL------HAAEILDMESRHISETETLKREH 2857



 Score =  140 bits (353), Expect = 1e-32
 Identities = 346/1772 (19%), Positives = 707/1772 (39%), Gaps = 295/1772 (16%)

Query: 45   KFKVESEQQYFEI-----EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL 99
            KFK E +    E+     E  LS+S    + E+++C  L +  E  +     +  ++   
Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSIHD 1567

Query: 100  EIAQDRNIAIQSQFTRTKEELEAEKRDLI------------------RTNERLSQELEYL 141
            EI+   ++    Q    +E+LE  +++L+                  R  ER  ++ E L
Sbjct: 1568 EISVS-SMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL 1626

Query: 142  TEDVKRLNEKLKESNTTKGE------LQLKLDELQA-SDVSVKYREKR-LEQEKELLHSQ 193
             E++KRLN +L + ++   E       ++ L+EL+A   +S+  REK   E       +Q
Sbjct: 1627 QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQ 1686

Query: 194  NTWLNT-ELKTKTDELLALGREKGNEILELKCNLENKKEEVSR--LEEQMNGLKTS---N 247
            N   N  E++ +T +   L R+  +   E+  N     ++ +   L+  +  +KT+    
Sbjct: 1687 NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE 1746

Query: 248  EHLQKHVEDLLTKLKEAK---------EQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
            E + +HV  +L +  +++         E +AS++   H E   H ++++    +   S+ 
Sbjct: 1747 ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE---HTRVTDESIPSYSGSDM 1803

Query: 299  KSNEL------TRAVEELHKLLKEAGEANKAI----QDHLLEVEQSKDQMEKEMLEKIGR 348
              N++      T    EL + L  +G A   I    ++ +L +        +++LE I  
Sbjct: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863

Query: 349  LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
               +LE+A    +   R+     +E             + +K   +L E  +     ++Q
Sbjct: 1864 TSSQLEHAKVTQTELMRESFRQKQE-----------ATESLKCQEELRERLHEESRAREQ 1912

Query: 409  LLLE--KLENKRINKYLDE---IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMK 463
            L +E  K E   I+ Y DE     ++++ K  I+ R  +E   A   +  L  + +Q  +
Sbjct: 1913 LAVELSKAEGV-IDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971

Query: 464  EIQRLQEDTDKANKQSSVLERD---------NRRMEIQVK------DLSQQIRVLLMELE 508
            E + L    +    ++  +E+            ++E+Q +      DL +Q++ L +++E
Sbjct: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031

Query: 509  EARGNHVIRDEEVSS--ADISSSSEVISQHLVSYRNI----------------EELQQQN 550
            E     +  ++E ++   D+   ++ + + L   R                  +E+Q+  
Sbjct: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091

Query: 551  QRLLVALR--ELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSI- 607
            Q+L V  R   + E + R E E  ++ + E   K    L   EQL++  Q + + ++ + 
Sbjct: 2092 QQLKVVPRFQPISEHQTR-EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLE 2150

Query: 608  VRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIE 667
             R R++ + LL     V+        D     +   +P  S  V   A    I+  E   
Sbjct: 2151 FRVRELEQALL-----VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE--- 2202

Query: 668  AKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
                +  L+E  E + +E+ EN   +NE++++L  Q   L  Q  + +T+L    +  ++
Sbjct: 2203 --KEITNLEEQLEQF-REELEN---KNEEVQQLHMQ---LEIQKKESTTRLQELEQENKL 2253

Query: 728  LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
             +D++E     I       +    +TQ Q  +     Q ++   EK    +   E + K 
Sbjct: 2254 FKDDMEKLGLAI------KESDAMSTQDQHVLFGKFAQIIQ---EKEVEIDQLNEQVTKL 2304

Query: 788  KEMLKL-SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEH 846
            ++ LK+ ++ ++ +++  L+ +   Q   +  L + Q  ++R+  E  ++L+  IEKL+ 
Sbjct: 2305 QQQLKITTDNKVIEEKNELIRDLETQ---IECLMSDQECVKRNREEEIEQLNEVIEKLQQ 2361

Query: 847  EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQ 906
            E++++ +K        H+L+   D      K QLD      L  ++ ++ A +E+  +K 
Sbjct: 2362 ELANIGQKTSMNA---HSLSEEAD----SLKHQLDVVIAEKLALEQQVETANEEMTFMK- 2413

Query: 907  HLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQ 966
                                            + L++T  ++N L + L +     E  +
Sbjct: 2414 --------------------------------NVLKETNFKMNQLTQELFSLKRERESVE 2441

Query: 967  AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI 1026
             + +  E S+N       + +  +EV L E A        K +E +   +  +++ + +I
Sbjct: 2442 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDA-------LKSLENQTYFKSFEENGKGSI 2494

Query: 1027 ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
             ++E +L +L+ T+S+   E+ +  ++       ++Q + + +   K  V  Q   E ++
Sbjct: 2495 INLETRLLQLESTVSAKDLELTQCYKQIK---DMQEQGQFETEMLQKKIVNLQKIVEEKV 2551

Query: 1087 MLHAADVEALQ-AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKC 1145
               AA V  +Q  A ++ +K     Q +    ++   Q L      + RE  L  ++S  
Sbjct: 2552 A--AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLN-----QLREDELGSDISAL 2604

Query: 1146 VCRCEDLEKQNRLLHDQIEKLSDKVVASVK---EGVQGPLNVSLSEEGKSQEQILEILRF 1202
              R  +LE Q   +H  +    ++V  + K   E  +  L +    EG  ++Q  +  + 
Sbjct: 2605 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2664

Query: 1203 IRREKEIAETRFEVAQV-ESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE 1261
              ++ E+ +T  E+    E   +   +E L  E    +  L + +EK +       Q E 
Sbjct: 2665 SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE-----KLQEEL 2719

Query: 1262 LMKKTETMNVVMETNKM---LREEKERL----EQDLQQMQAKVRKLELDILPLQEANAEL 1314
            L+K+T   ++  + +++   L E KE+L    ++D  ++Q   +    + LP++ + +  
Sbjct: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIA 2779

Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE-------------- 1360
            S+  G L+         +    A  Q  ++ Q +  +EE  +++S+              
Sbjct: 2780 SQTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAA 2837

Query: 1361 ----------------KEVHTKRIQQLTEEIGRLKA--------------EIARSNASLT 1390
                            K  H   +Q L EE G LKA              E+A S+A  T
Sbjct: 2838 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2897

Query: 1391 NNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKA 1450
              +        D  +      +   D+ ++    + +  T +  KKI    +  + E   
Sbjct: 2898 -REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE-GM 2955

Query: 1451 QQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETE 1510
            Q   + E+      DH  Q VS   ++E K  +N       SL+  +  +Q     +  +
Sbjct: 2956 QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI----SSLKDLITKMQLQREAEVYD 3011

Query: 1511 ARNLQEQTVQLQSELSRLRQD--LQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLA 1568
            +    E     + EL    Q   L++R+      R ++T         ++    +     
Sbjct: 3012 SSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3071

Query: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERE------------ 1616
            GV+ Q   E  +   R   L +        I AL +Q  GR   L+RE            
Sbjct: 3072 GVEYQAAMECLQKADRRSLLSE--------IQALHAQMNGRKITLKREQESEKPSQELLE 3123

Query: 1617 --LREHQERHLEQRDEPQEPSNKVPEQQRQIT 1646
              +++ Q + LE + E     ++  E Q Q++
Sbjct: 3124 YNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155



 Score =  136 bits (342), Expect = 3e-31
 Identities = 285/1390 (20%), Positives = 558/1390 (40%), Gaps = 279/1390 (20%)

Query: 242  GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
            G + S  HL+    +L  K  E +E    +EE         ++    +++A    +    
Sbjct: 149  GAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIIT 208

Query: 302  ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS-KDQMEKEMLEKIGRLEKELEN--AND 358
            +LT  +++  +      E ++ +++ L   EQS K Q++ + L+    L     +  A D
Sbjct: 209  QLTANLQQARR------EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAAD 262

Query: 359  LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKR 418
            LL A   K  IL+ ++                            +E QD LL E  + K+
Sbjct: 263  LLQA---KQQILTHQQ---------------------------QLEEQDHLL-EDYQKKK 291

Query: 419  IN-----KYLDEIVK--EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
             +      +L E +K  E+E    +    +EE +  +  +  L+ K+ +  K+   L++ 
Sbjct: 292  EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 351

Query: 472  TDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE 531
               A+K    L+        Q+   +Q+I+ + +EL  ++                 SSE
Sbjct: 352  LTTADKLLGELQE-------QIVQKNQEIKNMKLELTNSKQKE------------RQSSE 392

Query: 532  VISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE 591
             I Q + +   +EELQ++N +      ++ +  E+E Q        EL       + +++
Sbjct: 393  EIKQLMGT---VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMK 449

Query: 592  QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL--ASTPKRPSTSQ 649
            Q    RQH  Q+ +   R +      L   + + +      L +V++   +   + + SQ
Sbjct: 450  Q-ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 508

Query: 650  TVSTPAPVPVIESTEAIEAKAAL-KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLR 708
                   + +I     +E K AL +QL+++ E     +   E+IQ  + + + EQ + L 
Sbjct: 509  KEKLKEELGLI-----LEEKCALQRQLEDLVEELSFSR---EQIQRAR-QTIAEQESKLN 559

Query: 709  SQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
              +  +ST               VE  + EI S  E  ++L    + + ++ N   +   
Sbjct: 560  EAHKSLST---------------VEDLKAEIVSASESRKELEL--KHEAEVTNYKIKLEM 602

Query: 769  GANEKLAVAEVRAENLKKEKEMLKLS-----EVRLSQQRESLLAEQRGQNLLLTNLQTIQ 823
               EK AV +  AE+ + E E L+       E  LS+ +E L  E R   + +  L+   
Sbjct: 603  LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR---INIEKLKDNL 659

Query: 824  GILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT 882
            GI  + + +  Q  +S +IE ++ E  +L  K +N++    +  ++L   L+++K +   
Sbjct: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITK-QNQLILEISKLKDLQQSLVNSKSE--- 715

Query: 883  ETNLHLNTK----ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
            E  L +N      E+L+  +KE  TL+Q +  ++++      Q         KE  +DL 
Sbjct: 716  EMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM--------KEKENDLQ 767

Query: 939  SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-----KEKQVTEEVRKNIEVR 993
             +  Q E + + LK+  KT    ++ +  +  S EE L      K K       K IE+ 
Sbjct: 768  EKFAQLEAENSILKDEKKTLEDMLKIHTPV--SQEERLIFLDSIKSKSKDSVWEKEIEIL 825

Query: 994  LKESAEFQTQLEKKLMEVEKEK--------------QELQDD-------KRRAIESMEQQ 1032
            ++E+ + + Q  +   E+EK++              QELQ++       K    +S  +Q
Sbjct: 826  IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885

Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV-----EAQNKYERELM 1087
              E K  L ++  E+   LQR +      + +  D +++  +A      E   K   ELM
Sbjct: 886  ELEYKSKLKALNEELH--LQRINPTTVKMKSSVFD-EDKTFVAETLEMGEVVEKDTTELM 942

Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
                  E L+  K +  +++     L E  ++   ++    +   E  + LK E  +   
Sbjct: 943  ------EKLEVTKREKLELSQRLSDLSEQLKQKHGEI----SFLNEEVKSLKQEKEQVSL 992

Query: 1148 RCEDLE---KQNRLLH-----DQIEKLSDKVVASVKEGVQGPL----------------- 1182
            RC +LE     NR  +      Q+  L D VV     G +G +                 
Sbjct: 993  RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052

Query: 1183 -----NVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
                 N+++ EE K ++ IL+ L  + +E  +  T+      E+ + ++ + +L+ E  +
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ----PSENDKLQKELNVLKSEQND 1108

Query: 1238 LQDSLNAEREKVQVTAKT-MAQHEELMKKTETMNVVMETNKMLREEKERL----EQDLQQ 1292
            L+  + A+R  + +   T + Q  E M+         E +K L   KE L    E+ +++
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMEN--------EKDKALCSLKEELIFAQEEKIKE 1160

Query: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
            +Q K+ +LEL  +  QE   E      ++   +K + E+   +                 
Sbjct: 1161 LQ-KIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF----------------- 1202

Query: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
                           +Q L   +G       +   +  + +N    + E+       ++ 
Sbjct: 1203 ---------------LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN-------EDP 1240

Query: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
              +D   ++ D QE + T+        +   +Y +L   Q ++ +   Q +         
Sbjct: 1241 ELQDYRYEVQDFQENMHTLLN------KVTEEYNKLLVLQTRLSKIWGQQTDG------- 1287

Query: 1473 VQEMQELKETLNQAETKSKSLESQVENLQ--------KTLSEKETEARNLQEQTVQLQSE 1524
              +++  +E L + ET+  S+ SQ+ NL+        K  S ++ E   L+EQ  +L+S 
Sbjct: 1288 -MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESL 1346

Query: 1525 LSRLRQDLQD 1534
            +S L+Q L++
Sbjct: 1347 ISSLQQQLKE 1356



 Score =  135 bits (340), Expect = 5e-31
 Identities = 212/1010 (20%), Positives = 425/1010 (42%), Gaps = 145/1010 (14%)

Query: 745  RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE----VRLSQ 800
            R ++        EQ        L     +LA  +   E L +E E ++++     ++  Q
Sbjct: 135  REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ 194

Query: 801  QRESLLAEQRGQNLLLT-NLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858
            + E+ + ++ G    LT NLQ  Q   E+ ET  +   L+ Q +KL+ +   L+   E  
Sbjct: 195  EFEAAIKQRDGIITQLTANLQ--QARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251

Query: 859  VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
                H+ T      LL  K+Q+ T          LL++ QK+       +S ++ ++   
Sbjct: 252  RNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308

Query: 919  SSQRTGKGQPSNKED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT- 970
              ++  K + SNKE+       +++L +++ + E++  +LK++L T+   + + Q  +  
Sbjct: 309  EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQ 368

Query: 971  ----------SLEESLNKEKQVTEEVR------KNIEVRLKESAEFQTQLEKKL-----M 1009
                       L  S  KE+Q +EE++      + ++ R  + ++F+T + +++      
Sbjct: 369  KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR 428

Query: 1010 EVEKEKQELQDDKRRAIESMEQQL-----SELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
            ++E+ + EL +   + I  M+Q+L     +++++  +  + E++ AL+  S    NE Q 
Sbjct: 429  KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488

Query: 1065 R--RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
            +       +  I ++  N  + +L       E L    E+   +    + L E    +  
Sbjct: 489  KLMNVAINELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSRE 542

Query: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK------E 1176
            Q+   + +  E+E  L +E  K +   EDL+ +     +  ++L  K  A V       E
Sbjct: 543  QIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601

Query: 1177 GVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIA--------ETRFEVAQVE---SL 1222
             ++   N  L    +SQE  LE LR       E+E++        E R  + +++    +
Sbjct: 602  MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661

Query: 1223 RYRQRVELLERELQELQDSLNAEREK---------VQVTAKTMAQHEELMKKTETMNVVM 1273
             Y+Q+++ L+ E+ +  +++  E++          ++++     Q   +  K+E M + +
Sbjct: 662  HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721

Query: 1274 -----ETNKMLREEKER--LEQDLQQMQAKVRKLELDIL----PLQEANAELSEKSGMLQ 1322
                 E   + +EEKE+  LEQ++Q++Q K   LE  +      LQE  A+L  ++ +L+
Sbjct: 722  NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781

Query: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
             EKK LE+ +K         VSQ++     +  K  S+  V  K I+ L EE   LK   
Sbjct: 782  DEKKTLEDMLKIHTP-----VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK--- 833

Query: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
                      Q  IQ L E++ K R      +K+ +    ++QE+   + +VK      K
Sbjct: 834  ----------QQCIQ-LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882

Query: 1443 TQYE-----ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497
             + E     +LKA  +++       +    +  V  ++   + ETL   E   K     +
Sbjct: 883  NKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942

Query: 1498 ENLQKTLSEK---ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
            E L+ T  EK        +L EQ  Q   E+S L ++++    ++EQ+  +  E E    
Sbjct: 943  EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---- 998

Query: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614
              I+   ++  ++     Q++                   LD  +T      EG +S++ 
Sbjct: 999  --IIINHNRAENVQSCDTQVS-----------------SLLDGVVTMTSRGAEGSVSKVN 1039

Query: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDP 1664
            +   E  +  +E +   +  +     +Q Q+ L   P+  +      + P
Sbjct: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089



 Score =  129 bits (324), Expect = 3e-29
 Identities = 314/1499 (20%), Positives = 619/1499 (41%), Gaps = 195/1499 (13%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
            LQQ L+ T  NK+   ++ K E  + D +++I+ L    E  K   E++  ++ + +   
Sbjct: 2304 LQQQLKITTDNKV---IEEKNE-LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359

Query: 65   QERLVN----ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
            Q+ L N     +    SL  E + L +QL          ++     +A++ Q     EE+
Sbjct: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQL----------DVVIAEKLALEQQVETANEEM 2409

Query: 121  EAEKRDLIRTN---ERLSQELEYLT---EDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
               K  L  TN    +L+QEL  L    E V+++ + + E++       L  D+ +   V
Sbjct: 2410 TFMKNVLKETNFKMNQLTQELFSLKRERESVEKI-QSIPENSVNVAIDHLSKDKPELEVV 2468

Query: 175  SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL-KCNLENKK-EE 232
              +   K LE +      +     + +  +T  LL L      + LEL +C  + K  +E
Sbjct: 2469 LTEDALKSLENQTYFKSFEENGKGSIINLET-RLLQLESTVSAKDLELTQCYKQIKDMQE 2527

Query: 233  VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE--KFHNELNA------HIK 284
              + E +M   K  N  LQK VE+ +     ++ Q  +++E  KF  +            
Sbjct: 2528 QGQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTN 2585

Query: 285  LSNLYKSAADDSEA-------KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
            + NL +   D+  +       + +EL   V E+H  L    E  +  + ++LE E+   +
Sbjct: 2586 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645

Query: 338  MEK--EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
            ++K  E  EK  R +++  +  D+           S EE    +   A  A+ V    +L
Sbjct: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705

Query: 396  TELYNAYVETQDQLLLEKLENKRINKYLDEI---VKEVEAKAPILKRQRE-EYERAQKAV 451
                    + Q++LL+++     + K L ++   + E + K  IL+++ E E + ++KA 
Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2765

Query: 452  A--SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
                L +KL ++      +   TD   K SS     N+  +I VK+   QI  L  E   
Sbjct: 2766 MFEPLPIKLSKS------IASQTDGTLKISS----SNQTPQILVKNAGIQIN-LQSECSS 2814

Query: 510  ARGNHVIRD--EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRERE 567
                 +I    E++       ++E++    +  R+I E +   +   VA++ L     +E
Sbjct: 2815 EEVTEIISQFTEKIEKMQELHAAEILD---MESRHISETETLKREHYVAVQLL-----KE 2866

Query: 568  EQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYR-ILLSQTTGVAI 626
            E  T  + I  L+ K  S++ EL     S  +Q + + S     D  + I L+ + G  I
Sbjct: 2867 ECGTLKAVIQCLRSKEGSSIPELAH---SDAYQTREICSSDSGSDWGQGIYLTHSQGFDI 2923

Query: 627  PLHASSLDDVSLA-STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685
                   +  S   S PK+            + V+  TE+  +      +Q++ E + +E
Sbjct: 2924 ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEE 2983

Query: 686  KAE--------NEKIQNEQLEKLQEQVTDLRSQNT--------KISTQLDFASKRYEMLQ 729
            +           + I   QL++  E     +S  +         ++ Q  F  +R  +L 
Sbjct: 2984 RKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLA 3043

Query: 730  DNVEGYRREITSLHERNQK-----LTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
                 +R E+T+L   +       L    Q+Q        + L+ A+ +  ++E++A + 
Sbjct: 3044 ----AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA 3099

Query: 785  KKEKEMLKLSEVRLSQQRESLLAE---QRGQNLLLTNLQTIQGILERSETETKQRLSSQ- 840
            +     + L   + S++    L E   Q+ Q+ +L     +  + +R+ TE +++LSS+ 
Sbjct: 3100 QMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA-TELQEQLSSEK 3158

Query: 841  --IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQ 898
              + +L+ E++  K +LE  ++ +H   + L+   L+ K + D    +HL   + L + Q
Sbjct: 3159 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD---EVHL-LNDTLASEQ 3214

Query: 899  KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958
            K+   L+  L   + ++        G+ +  +KE+++DL   L   +++   L   L+  
Sbjct: 3215 KKSRELQWALEKEKAKL--------GRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3266

Query: 959  TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR-LKESAEFQTQLEKKLMEVEKEKQ- 1016
               + + Q  + S  + +  + Q++EE  +N+E++ L ES + + +     ++ E+E   
Sbjct: 3267 KQLLNESQQKIES--QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHA 3324

Query: 1017 ELQDD-----------KRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNE 1061
            +LQ                 ++ +++QL E    +  + NE +    ++LQ       + 
Sbjct: 3325 QLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR 3384

Query: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEA-LQAAKEQVSKMASVRQHLEETTQKA 1120
            Q  R+  Q + +   E Q K   EL     D++  L+  ++QV K+    Q L+   Q+ 
Sbjct: 3385 QVHRKTLQTEQEANTEGQKKMH-ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3443

Query: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180
            + Q LE +   E R  + ++              +N +L  +IE          KE    
Sbjct: 3444 QKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE-------GETKESNYA 3496

Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
             L + ++  G      LE+   IR++ +   ++ +V        ++  E L+ E  + +D
Sbjct: 3497 KL-IEMNGGGTGCNHELEM---IRQKLQCVASKLQVLP------QKASERLQFETADDED 3546

Query: 1241 SL----NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296
             +    N +   +Q+   T  Q EE    + + +    T ++LR+  E            
Sbjct: 3547 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAE------------ 3594

Query: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR-----NQHLVSQQKDPDT 1351
                      L    ++L+E+   L+     LEE ++ ++       N    S     + 
Sbjct: 3595 ----------LTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANI 3644

Query: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410
            E    + SEKEV  +    L + + R +AE+ +  A L  N +L+Q+L  D   V  ++
Sbjct: 3645 EAI--IASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEHVTLKR 3700


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  180 bits (457), Expect = 1e-44
 Identities = 265/1267 (20%), Positives = 529/1267 (41%), Gaps = 150/1267 (11%)

Query: 454  LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
            LSV+L  A  +I+RL+++ ++  +Q    +++  +MEI++K L Q+   LL +   AR  
Sbjct: 249  LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR-- 306

Query: 514  HVIRDEEVSSADISSSSEVISQHLVSYRN-----------IEELQQQNQRLLVALRELGE 562
             + RDE  +  + +   + +   +  Y+            +EEL++ NQ LL     L +
Sbjct: 307  -MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365

Query: 563  TREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
              + E     S K+ EL+ +      +L  +   R    + ++ ++ +     +   Q+ 
Sbjct: 366  --QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423

Query: 623  GVAIPLHASSLDDVS----LASTPKRP-------------------STSQTVSTPAPVPV 659
              ++ L    L+ +S    L+  P++                    + S T +       
Sbjct: 424  DESLHL-GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482

Query: 660  IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-LEKLQEQVTDLRSQNTK----I 714
            ++S E   +K    + +    + K E  ENE +Q +Q L+  Q    DL  +  +    I
Sbjct: 483  VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542

Query: 715  STQLDFASKRYEMLQDNVEGYRREITSLHERNQ-KLTATTQKQEQIINTMTQDLRGANEK 773
             T  + + ++ ++L+   E   + ++SL +R+Q    A  +  E+    + + ++  + K
Sbjct: 543  ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602

Query: 774  LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
            L+  E     +KKE E  K    R  +    L   ++   LL   +  ++   E+ E   
Sbjct: 603  LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-- 660

Query: 834  KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---QLDTETNLHLNT 890
               L  +  +LE E   LKK L++         +NL  QL   ++   QLD E NL L  
Sbjct: 661  ---LEQENSELERENRKLKKTLDS--------FKNLTFQLESLEKENSQLDEE-NLELRR 708

Query: 891  K-ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
              E LK A  ++A L+  L N E++   +  ++  +   ++ +  + L    +  + +  
Sbjct: 709  NVESLKCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766

Query: 950  DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
             L++ L+ S   ++Q       LE  L   +   + ++KN+E  LK S++   QLEK+  
Sbjct: 767  RLQKTLENSNKKIQQ-------LESELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENK 818

Query: 1010 EVEKEKQELQDDKRRAIESMEQ--QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD 1067
             +E+E  +L+ DK++  +  ++  Q +E+K T     N     L++ +  LS E    ++
Sbjct: 819  SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878

Query: 1068 CQEQAKIAVEAQNKYERELMLHAA-DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLE 1126
               + K  +E +NK   EL+  A  D++ L   +E +       Q +    +K   +L +
Sbjct: 879  SCVRLK-ELEKENK---ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934

Query: 1127 CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
               +   +ER+L DE S         + + +LL  ++E    K +  +KE     L   L
Sbjct: 935  IGLN---KERLLHDEQST--------DDRYKLLESKLESTLKKSL-EIKEEKIAALEARL 982

Query: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
             E     +Q+ + L+ +++              E+L+ RQ  E + +    +    N   
Sbjct: 983  EESTNYNQQLRQELKTVKKN------------YEALKQRQDEERMVQSSPPISGEDNKWE 1030

Query: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKM-LREEKERLEQDLQQMQAKVRKLELDIL 1305
             + Q T + + + ++ + + E  N  ++  K  L+ + ++LE     +QA++  L+   +
Sbjct: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090

Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
             LQE N  L  ++  LQ E   L         +N  L+ QQ   + E    ++ E+E   
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKEREDLK 1149

Query: 1366 KRIQQLT---EEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
                 L    E++  L    A    SL +    ++S  ++L       E   +DL+ +  
Sbjct: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-------EVEHRDLEDRYN 1202

Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
             + ++   +  ++K+          LK +Q+K++  +        E      E   L  T
Sbjct: 1203 QLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1252

Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
             +Q   +++ L++  +NL+  L+  + E   L+ +  +L+ +  +L         Q E L
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1312

Query: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL 1602
             Q     EE+ R           HL      L  +N  L ++N    + KD   V     
Sbjct: 1313 SQLKGNLEEENR-----------HLLDQIQTLMLQNRTLLEQN---MESKDLFHVE---- 1354

Query: 1603 KSQYEGRISRLERELREHQERHLEQ-----RDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
            + QY  +++ L R+  + +E+ ++Q        P+   N +  + R++       + ER 
Sbjct: 1355 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1414

Query: 1658 IASTSDP 1664
             + T  P
Sbjct: 1415 KSLTLTP 1421



 Score =  152 bits (383), Expect = 5e-36
 Identities = 346/1679 (20%), Positives = 684/1679 (40%), Gaps = 291/1679 (17%)

Query: 28   FLADQQSEIDGLKGRHEKFKVESEQ----QYFEIEKRLSHSQERLVNETRECQSLRLELE 83
            FL    S      G     + ES Q    +  + + ++   ++ L  +T +    + ELE
Sbjct: 223  FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282

Query: 84   KLNNQLKALTEKNKEL-------EIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
            ++  +LK L ++N  L        + +D   A++ +  R  ++LE+E   + R  ERL  
Sbjct: 283  QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESE---VSRYKERL-H 337

Query: 137  ELEYL---TEDVKRLNEKLKESNTTKGELQL--------KLDELQASDVSVKYREKRLEQ 185
            ++E+     E++K  N+ L E+ T   E QL        KL EL+  ++ +K +   +E 
Sbjct: 338  DIEFYKARVEELKEDNQVLLETKTML-EDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396

Query: 186  EKEL-------LHSQNTWLNTELKTKTDELLALGRE-----KGNEILELKCNLENKKEEV 233
            E+++       L  +N  L    K   DE L LG E     + +E+ E     ++   EV
Sbjct: 397  ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE--APQKSLGHEV 454

Query: 234  SRL-EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
            + L   ++  L+  N+ L K VE+L T + ++ E  AS   K   E   + +LS   +  
Sbjct: 455  NELTSSRLLKLEMENQSLTKTVEELRTTV-DSVEGNASKILKMEKE---NQRLSKKVEIL 510

Query: 293  ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
             ++   +   L         L+KE  +  K I       E  ++  E++    I  LE+E
Sbjct: 511  ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI-------ETLRENSERQ----IKILEQE 559

Query: 353  LENANDLLSATKRKGAILSEEEL-----------AAMSPTAAAVAKI------------- 388
             E+ N  +S+ +++  I +E  +            ++  T++ ++KI             
Sbjct: 560  NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619

Query: 389  -VKPGMKLTELYNA--YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445
              + G +  EL N   ++E +++LL +K+ N +I     E ++ +E +   L+R+  + +
Sbjct: 620  YKEKGERAEELENELHHLEKENELLQKKITNLKIT---CEKIEALEQENSELERENRKLK 676

Query: 446  RAQKAVASLSVKLEQAMKEIQRLQEDTDK----------ANKQSSVLERDNRRMEIQVKD 495
            +   +  +L+ +LE   KE  +L E+  +          A+ + + L+ +N+ +E + + 
Sbjct: 677  KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736

Query: 496  LSQQIRVLLMELEEARGNHV------IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
            L + + +L    ++     V      I ++ +     +S+ ++  Q L S   +++L+ +
Sbjct: 737  LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI--QQLES--ELQDLEME 792

Query: 550  NQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQLRKSRQHQMQLVDSIV 608
            NQ L   L EL  + +R EQ    +K  E +  +LE    +LE+  K  + Q ++ D+ +
Sbjct: 793  NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852

Query: 609  RQRDMYRILL---SQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665
             + ++    L   ++T    I ++  S   V L    K                 E+ E 
Sbjct: 853  EENNVKIGNLEKENKTLSKEIGIYKESC--VRLKELEK-----------------ENKEL 893

Query: 666  IE-AKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724
            ++ A   +K L  + E+   EK + +++ N+ LEKL  ++  +     ++         R
Sbjct: 894  VKRATIDIKTLVTLREDLVSEKLKTQQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDR 952

Query: 725  YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
            Y++L+  +E   ++  SL  + +K+ A   + E+  N   Q LR   ++L   +   E L
Sbjct: 953  YKLLESKLESTLKK--SLEIKEEKIAALEARLEESTN-YNQQLR---QELKTVKKNYEAL 1006

Query: 785  KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844
            K+ ++     E R+ Q    +  E         + +T + +L     + K RL  ++E+ 
Sbjct: 1007 KQRQD-----EERMVQSSPPISGEDNKWE--RESQETTRELL-----KVKDRL-IEVERN 1053

Query: 845  EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT--ETNLHLNTKELLKNAQKEIA 902
               +   K+ L+ +++Q  T   NL  Q+L  +RQ  +  E N  L T+      Q E +
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN--AKLQVENS 1111

Query: 903  TLKQH---LSNMEVQVASQSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
            TL      L N   Q+  Q S    + +     +ED+  L   L +  E++  L ER   
Sbjct: 1112 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER--- 1168

Query: 958  STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE--KKLMEVEKEK 1015
                  +Y++++ S   +L    +  E   +++E R  +  + + QLE  +K+++VE+EK
Sbjct: 1169 ---QASEYESLI-SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224

Query: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIA 1075
              L++     + +  ++L      L    N     L + +  L  + +  +     +K+ 
Sbjct: 1225 MLLENKNHETVAAEYKKLCGENDRL----NHTYSQLLKETEVLQTDHKNLKSLLNNSKL- 1279

Query: 1076 VEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ---LLECKASWE 1132
               Q + E E                  SK+    Q L+ T+ K  +Q   L + K + E
Sbjct: 1280 --EQTRLEAEF-----------------SKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1320

Query: 1133 ERERMLKDEVSKCVCRCEDLEKQN------------------RLLHDQIEKLSDKVVASV 1174
            E  R L D++   + +   L +QN                    L  Q EKL +K++   
Sbjct: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY 1380

Query: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234
            K     P         +     L++ + I+ +K+I   R +   +   R       L+  
Sbjct: 1381 KFYDPSP------PRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLP 1434

Query: 1235 LQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQ 1294
             Q+ QDS +       V + ++   + L  K  +M V ++    LR       +D  +M+
Sbjct: 1435 HQDSQDSSS-------VGSNSLEDGQTLGTKKSSM-VALKRLPFLRNR----PKDKDKMK 1482

Query: 1295 AKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ-------------- 1340
            A  R+  + +  L ++     + +G    E   + +D+   K R +              
Sbjct: 1483 ACYRR-SMSMNDLVQSMVLAGQWTG--STENLEVPDDISTGKRRKELGAMAFSTTAINFS 1539

Query: 1341 ------HLVSQQ--KDPDTEEYRKLLSE---------KEVHTKRIQQLTEEIGRLKAEIA 1383
                     S+Q   + DT  +  +  +           VH  R   L  + GR     +
Sbjct: 1540 TVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASL--DSGRTSTSNS 1597

Query: 1384 RSNASL-------TNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK- 1435
             +NASL        NNQ+  QS       +  + E       + I  ++ + ++   ++ 
Sbjct: 1598 NNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQH 1657

Query: 1436 KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES 1495
            KI    ++++ ++K             +G    + V++Q+  E    L   + KS S E+
Sbjct: 1658 KISETLESRHHKIK-------------TGSPGSEVVTLQQFLEESNKLTSVQIKSSSQEN 1704

Query: 1496 QVENLQKTLSEKETEARNLQEQTVQLQSELS-RLRQDLQDRTTQEEQLRQQITEKEEKT 1553
             ++ + K+LS         +  +  L   +S +   D  DR T + +  +    K E T
Sbjct: 1705 LLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDT 1763



 Score =  145 bits (365), Expect = 6e-34
 Identities = 236/1129 (20%), Positives = 473/1129 (41%), Gaps = 158/1129 (13%)

Query: 16   KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC 75
            K+ + ++  +   +A +QS  + L   H  +++E   +  E+ +    S    VNE    
Sbjct: 404  KIEELMEENMTLEMAQKQSMDESL---HLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460

Query: 76   QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS 135
            + L+LE+E      ++LT+  +EL    D      S+  + ++E           N+RLS
Sbjct: 461  RLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASKILKMEKE-----------NQRLS 504

Query: 136  QELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR----LEQEKELLH 191
            +++E L  ++ +  + L+       +L  +  +L+ +  +++   +R    LEQE E L+
Sbjct: 505  KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564

Query: 192  SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ 251
               + L    +    E      EK N+IL    +++    ++S++E +   +K   EH  
Sbjct: 565  QTVSSLRQRSQISA-EARVKDIEKENKILHE--SIKETSSKLSKIEFEKRQIKKELEHY- 620

Query: 252  KHVEDLLTKLKEAKEQQASMEEKFH-----NELNAHIKLSNLYKSAADDSEAKSNELTRA 306
                      KE  E+   +E + H     NEL    K++NL K   +  EA   E +  
Sbjct: 621  ----------KEKGERAEELENELHHLEKENEL-LQKKITNL-KITCEKIEALEQENSEL 668

Query: 307  VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
              E  KL K+  ++ K +   L  +E+   Q+++E LE    L + +E+     ++ K  
Sbjct: 669  ERENRKL-KKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLK--CASMKMA 721

Query: 367  GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
               L  +EL +         +++K   K TE      +  D      +EN+R+ K L+  
Sbjct: 722  QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD------IENQRLQKTLENS 775

Query: 427  VKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
             K+++     L+    E +  QK +  L +    + K +++L+++     +++S LE+D 
Sbjct: 776  NKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQLEKDK 831

Query: 487  RRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR----N 542
            +++E + K L QQ  +    LEE           V   ++   ++ +S+ +  Y+     
Sbjct: 832  KQLEKENKRLRQQAEIKDTTLEE---------NNVKIGNLEKENKTLSKEIGIYKESCVR 882

Query: 543  IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK--LESALTELEQLRKSRQ-- 598
            ++EL+++N+ L+       +T     ++  S K+   Q+   LE    ELE++  +++  
Sbjct: 883  LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942

Query: 599  -HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPV 657
             H  Q  D      D Y++L S+             + ++        ST+        +
Sbjct: 943  LHDEQSTD------DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996

Query: 658  PVIEST-EAIEAKAALKQLQEIF-----ENYKKEKAENEKIQ-----NEQLEKLQEQVTD 706
              ++   EA++ +   +++ +       E+ K E+   E  +      ++L +++     
Sbjct: 997  KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056

Query: 707  LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN---QKLTATTQKQEQIINTM 763
            L+++   + TQL     +   LQ  +   +R+  SL E+N   Q   A  Q +   +N+ 
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116

Query: 764  TQDLRGANEKLAVAEVRAEN------------------LKKEKEMLKLSEVRLSQQRESL 805
            +  L   N +L + +   EN                  L K+ E L+L   R + + ESL
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176

Query: 806  LAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHT 864
            +++         NL+     LE R     KQ+   Q+E LE  +   ++K+  E +   T
Sbjct: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK--GQLEDLEKMLKVEQEKMLLENKNHET 1234

Query: 865  LTRNL------DVQLLDTKRQLDTETNL----HLNTKELLKNAQKEIATLKQHLSNMEVQ 914
            +          + +L  T  QL  ET +    H N K LL N++ E   L+   S ++ Q
Sbjct: 1235 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294

Query: 915  VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSN-VEQYQAMV---- 969
                             + +D   ++L    E ++ LK  L+    + ++Q Q ++    
Sbjct: 1295 Y----------------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNR 1338

Query: 970  TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESM 1029
            T LE+++  +     E R+ I+ +L E    + +LE+K+M+  K         RR    +
Sbjct: 1339 TLLEQNMESKDLFHVEQRQYID-KLNELRRQKEKLEEKIMDQYKFYD--PSPPRRRGNWI 1395

Query: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNE----QQARRDCQEQAKI 1074
              ++ +L K+   +  E Q++L    T   +     Q   +D Q+ + +
Sbjct: 1396 TLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSV 1444



 Score =  127 bits (318), Expect = 2e-28
 Identities = 189/899 (21%), Positives = 395/899 (43%), Gaps = 120/899 (13%)

Query: 819  LQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEV-----EQRHTLTRNLDVQL 873
            ++ IQG+    + +TK  +++ I+++ H   ++      EV     E    L +N+ + L
Sbjct: 142  IERIQGL----DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197

Query: 874  LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
               KR +D E + H  T   L   +  +  L    S+ +    S   +RT   Q  + E 
Sbjct: 198  ---KRLID-ERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE- 252

Query: 934  VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEE---SLNKEKQVTEEVRKNI 990
            + D  +++R+  +++ +  E+L      +EQ +  +  L++   +L  + +     R  +
Sbjct: 253  LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312

Query: 991  EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA 1050
            +  L+E A    +++K   EV + K+ L D     IE  + ++ ELK        E  + 
Sbjct: 313  DA-LREKA---VRVDKLESEVSRYKERLHD-----IEFYKARVEELK--------EDNQV 355

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR 1110
            L    T L ++ +  R   ++    +E +N  + +  LH  ++E     ++++ ++    
Sbjct: 356  LLETKTMLEDQLEGTRARSDKLH-ELEKEN-LQLKAKLHDMEMER-DMDRKKIEELMEEN 412

Query: 1111 QHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
              LE   +++  + L     WE  +     E+S+          Q  L H+  E  S ++
Sbjct: 413  MTLEMAQKQSMDESLHL--GWELEQISRTSELSEA--------PQKSLGHEVNELTSSRL 462

Query: 1171 VASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVEL 1230
            +              L  E +S  + +E LR      E   ++    + E+ R  ++VE+
Sbjct: 463  L-------------KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509

Query: 1231 LEREL-QELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETN-KMLREEKERLEQ 1288
            LE E+ QE Q   N +     ++   M +  +L K  ET+    E   K+L +E E L Q
Sbjct: 510  LENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565

Query: 1289 DLQQM--------QAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
             +  +        +A+V+ +E +   L E+  E S K   ++ EK+ ++++++ +K + +
Sbjct: 566  TVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625

Query: 1341 HLVSQQKD-----PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNL 1395
                 + +      + E  +K ++  ++  ++I+ L +E   L+ E  +   +L + +NL
Sbjct: 626  RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685

Query: 1396 ---IQSLKEDLNKVRTEKETIQKDLDA------KIIDIQEKVKTITQVK----------- 1435
               ++SL+++ +++  E   +++++++      K+  +Q + K +   K           
Sbjct: 686  TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745

Query: 1436 ---KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
               K   R +  Y+ L  +  ++ +T   S+   Q+    +Q+++   +TL +   + K 
Sbjct: 746  ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKI 805

Query: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ--DLQDRTTQEEQLRQQITEKE 1550
               ++E L+K     E E   L++   QL+ E  RLRQ  +++D T +E  ++    EKE
Sbjct: 806  SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865

Query: 1551 EKT-RKAIVAAKSKIAHLAGVKDQLTKENEELKQR-----NGALDQQKDELDVRITALKS 1604
             KT  K I   K     L     +L KEN+EL +R        +  ++D +  ++     
Sbjct: 866  NKTLSKEIGIYKESCVRL----KELEKENKELVKRATIDIKTLVTLREDLVSEKLKT--Q 919

Query: 1605 QYEGRISRLERELRE---HQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIAS 1660
            Q    + +L  EL +   ++ER L   ++  +   K+ E + + TLK +    E  IA+
Sbjct: 920  QMNNDLEKLTHELEKIGLNKERLLHD-EQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  180 bits (456), Expect = 2e-44
 Identities = 265/1267 (20%), Positives = 529/1267 (41%), Gaps = 149/1267 (11%)

Query: 454  LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
            LSV+L  A  +I+RL+++ ++  +Q    +++  +MEI++K L Q+   LL +   AR  
Sbjct: 249  LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR-- 306

Query: 514  HVIRDEEVSSADISSSSEVISQHLVSYRN-----------IEELQQQNQRLLVALRELGE 562
             + RDE  +  + +   + +   +  Y+            +EEL++ NQ LL     L +
Sbjct: 307  -MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365

Query: 563  TREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
              + E     S K+ EL+ +      +L  +   R    + ++ ++ +     +   Q+ 
Sbjct: 366  --QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423

Query: 623  GVAIPLHASSLDDVS----LASTPKRP-------------------STSQTVSTPAPVPV 659
              ++ L    L+ +S    L+  P++                    + S T +       
Sbjct: 424  DESLHL-GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482

Query: 660  IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-LEKLQEQVTDLRSQNTK----I 714
            ++S E   +K    + +    + K E  ENE +Q +Q L+  Q    DL  +  +    I
Sbjct: 483  VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542

Query: 715  STQLDFASKRYEMLQDNVEGYRREITSLHERNQ-KLTATTQKQEQIINTMTQDLRGANEK 773
             T  + + ++ ++L+   E   + ++SL +R+Q    A  +  E+    + + ++  + K
Sbjct: 543  ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602

Query: 774  LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
            L+  E     +KKE E  K    R  +    L   ++   LL   +  ++   E+ E   
Sbjct: 603  LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-- 660

Query: 834  KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---QLDTETNLHLNT 890
               L  +  +LE E   LKK L++         +NL  QL   ++   QLD E NL L  
Sbjct: 661  ---LEQENSELERENRKLKKTLDS--------FKNLTFQLESLEKENSQLDEE-NLELRR 708

Query: 891  K-ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
              E LK A  ++A L+  L N E++   +  ++  +   ++ +  + L    +  + +  
Sbjct: 709  NVESLKCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766

Query: 950  DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
             L++ L+ S   ++Q       LE  L   +   + ++KN+E  LK S++   QLEK+  
Sbjct: 767  RLQKTLENSNKKIQQ-------LESELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENK 818

Query: 1010 EVEKEKQELQDDKRRAIESMEQ--QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD 1067
             +E+E  +L+ DK++  +  ++  Q +E+K T     N     L++ +  LS E    ++
Sbjct: 819  SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878

Query: 1068 CQEQAKIAVEAQNKYERELMLHAA-DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLE 1126
               + K  +E +NK   EL+  A  D++ L   +E +       Q +    +K   +L +
Sbjct: 879  SCVRLK-ELEKENK---ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934

Query: 1127 CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
               +   +ER+L DE S         + + +LL  ++E    K +  +KE     L   L
Sbjct: 935  IGLN---KERLLHDEQSTD-------DSRYKLLESKLESTLKKSL-EIKEEKIAALEARL 983

Query: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
             E     +Q+ + L+ +++              E+L+ RQ  E + +    +    N   
Sbjct: 984  EESTNYNQQLRQELKTVKKN------------YEALKQRQDEERMVQSSPPISGEDNKWE 1031

Query: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKM-LREEKERLEQDLQQMQAKVRKLELDIL 1305
             + Q T + + + ++ + + E  N  ++  K  L+ + ++LE     +QA++  L+   +
Sbjct: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091

Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
             LQE N  L  ++  LQ E   L         +N  L+ QQ   + E    ++ E+E   
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKEREDLK 1150

Query: 1366 KRIQQLT---EEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
                 L    E++  L    A    SL +    ++S  ++L       E   +DL+ +  
Sbjct: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-------EVEHRDLEDRYN 1203

Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
             + ++   +  ++K+          LK +Q+K++  +        E      E   L  T
Sbjct: 1204 QLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1253

Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
             +Q   +++ L++  +NL+  L+  + E   L+ +  +L+ +  +L         Q E L
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1313

Query: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL 1602
             Q     EE+ R           HL      L  +N  L ++N    + KD   V     
Sbjct: 1314 SQLKGNLEEENR-----------HLLDQIQTLMLQNRTLLEQN---MESKDLFHVE---- 1355

Query: 1603 KSQYEGRISRLERELREHQERHLEQ-----RDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
            + QY  +++ L R+  + +E+ ++Q        P+   N +  + R++       + ER 
Sbjct: 1356 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1415

Query: 1658 IASTSDP 1664
             + T  P
Sbjct: 1416 KSLTLTP 1422



 Score =  160 bits (405), Expect = 1e-38
 Identities = 338/1658 (20%), Positives = 669/1658 (40%), Gaps = 276/1658 (16%)

Query: 28   FLADQQSEIDGLKGRHEKFKVESEQ----QYFEIEKRLSHSQERLVNETRECQSLRLELE 83
            FL    S      G     + ES Q    +  + + ++   ++ L  +T +    + ELE
Sbjct: 223  FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282

Query: 84   KLNNQLKALTEKNKEL-------EIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
            ++  +LK L ++N  L        + +D   A++ +  R  ++LE+E   + R  ERL  
Sbjct: 283  QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESE---VSRYKERL-H 337

Query: 137  ELEYL---TEDVKRLNEKLKESNTTKGELQL--------KLDELQASDVSVKYREKRLEQ 185
            ++E+     E++K  N+ L E+ T   E QL        KL EL+  ++ +K +   +E 
Sbjct: 338  DIEFYKARVEELKEDNQVLLETKTML-EDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396

Query: 186  EKEL-------LHSQNTWLNTELKTKTDELLALGRE-----KGNEILELKCNLENKKEEV 233
            E+++       L  +N  L    K   DE L LG E     + +E+ E     ++   EV
Sbjct: 397  ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE--APQKSLGHEV 454

Query: 234  SRL-EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
            + L   ++  L+  N+ L K VE+L T + ++ E  AS   K   E   + +LS   +  
Sbjct: 455  NELTSSRLLKLEMENQSLTKTVEELRTTV-DSVEGNASKILKMEKE---NQRLSKKVEIL 510

Query: 293  ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
             ++   +   L         L+KE  +  K I       E  ++  E++    I  LE+E
Sbjct: 511  ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI-------ETLRENSERQ----IKILEQE 559

Query: 353  LENANDLLSATKRKGAILSEEEL-----------AAMSPTAAAVAKI------------- 388
             E+ N  +S+ +++  I +E  +            ++  T++ ++KI             
Sbjct: 560  NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619

Query: 389  -VKPGMKLTELYNA--YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445
              + G +  EL N   ++E +++LL +K+ N +I     E ++ +E +   L+R+  + +
Sbjct: 620  YKEKGERAEELENELHHLEKENELLQKKITNLKIT---CEKIEALEQENSELERENRKLK 676

Query: 446  RAQKAVASLSVKLEQAMKEIQRLQEDTDK----------ANKQSSVLERDNRRMEIQVKD 495
            +   +  +L+ +LE   KE  +L E+  +          A+ + + L+ +N+ +E + + 
Sbjct: 677  KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736

Query: 496  LSQQIRVLLMELEEARGNHV------IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
            L + + +L    ++     V      I ++ +     +S+ ++  Q L S   +++L+ +
Sbjct: 737  LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI--QQLES--ELQDLEME 792

Query: 550  NQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQLRKSRQHQMQLVDSIV 608
            NQ L   L EL  + +R EQ    +K  E +  +LE    +LE+  K  + Q ++ D+ +
Sbjct: 793  NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852

Query: 609  RQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA 668
             +                       ++V + +  K   T              S E    
Sbjct: 853  EE-----------------------NNVKIGNLEKENKTL-------------SKEIGIY 876

Query: 669  KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728
            K +  +L+E+ E   KE  +   I  + L  L+E +   + +  +++  L+  +   E +
Sbjct: 877  KESCVRLKEL-EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935

Query: 729  QDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788
              N E    +  S  +   KL      + ++ +T+ + L    EK+A  E R E      
Sbjct: 936  GLNKERLLHDEQSTDDSRYKLL-----ESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990

Query: 789  EMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQG---ILERSETETKQRLSS------ 839
            + L+  E++  ++    L +++ +  ++ +   I G     ER   ET + L        
Sbjct: 991  QQLR-QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049

Query: 840  QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT--ETNLHLNTKELLKNA 897
            ++E+    +   K+ L+ +++Q  T   NL  Q+L  +RQ  +  E N  L T+      
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN--AKL 1107

Query: 898  QKEIATLKQH---LSNMEVQVASQSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLK 952
            Q E +TL      L N   Q+  Q S    + +     +ED+  L   L +  E++  L 
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1167

Query: 953  ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE--KKLME 1010
            ER         +Y++++ S   +L    +  E   +++E R  +  + + QLE  +K+++
Sbjct: 1168 ER------QASEYESLI-SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220

Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
            VE+EK  L++     + +  ++L      L    N     L + +  L  + +  +    
Sbjct: 1221 VEQEKMLLENKNHETVAAEYKKLCGENDRL----NHTYSQLLKETEVLQTDHKNLKSLLN 1276

Query: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ---LLEC 1127
             +K+    Q + E E                  SK+    Q L+ T+ K  +Q   L + 
Sbjct: 1277 NSKL---EQTRLEAEF-----------------SKLKEQYQQLDITSTKLNNQCELLSQL 1316

Query: 1128 KASWEERERMLKDEVSKCVCRCEDLEKQN------------------RLLHDQIEKLSDK 1169
            K + EE  R L D++   + +   L +QN                    L  Q EKL +K
Sbjct: 1317 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376

Query: 1170 VVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVE 1229
            ++   K     P         +     L++ + I+ +K+I   R +   +   R      
Sbjct: 1377 IMDQYKFYDPSP------PRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEG 1430

Query: 1230 LLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLRE---EKERL 1286
             L+   Q+ QDS +     ++   +T+       KK+ TMN ++++  +  +     E L
Sbjct: 1431 FLQLPHQDSQDSSSVGSNSLE-DGQTLG-----TKKSSTMNDLVQSMVLAGQWTGSTENL 1484

Query: 1287 EQDLQQMQAKVRKLELDILPLQEA--NAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
            E        K RK EL  +       N      S   ++++ +  +D   ++  +   VS
Sbjct: 1485 EVPDDISTGKRRK-ELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVS 1543

Query: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASL-------TNNQNLIQ 1397
                          +   VH  R   L  + GR     + +NASL        NNQ+  Q
Sbjct: 1544 DDSS----------TGSRVHASRPASL--DSGRTSTSNSNNNASLHEVKAGAVNNQSRPQ 1591

Query: 1398 SLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK-KIGRRYKTQYEELKAQQDKVM 1456
            S       +  + E       + I  ++ + ++   ++ KI    ++++ ++K       
Sbjct: 1592 SHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIK------- 1644

Query: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
                  +G    + V++Q+  E    L   + KS S E+ ++ + K+LS         + 
Sbjct: 1645 ------TGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKP 1698

Query: 1517 QTVQLQSELS-RLRQDLQDRTTQEEQLRQQITEKEEKT 1553
             +  L   +S +   D  DR T + +  +    K E T
Sbjct: 1699 VSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDT 1736



 Score =  146 bits (369), Expect = 2e-34
 Identities = 240/1148 (20%), Positives = 480/1148 (41%), Gaps = 195/1148 (16%)

Query: 16   KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC 75
            K+ + ++  +   +A +QS  + L   H  +++E   +  E+ +    S    VNE    
Sbjct: 404  KIEELMEENMTLEMAQKQSMDESL---HLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460

Query: 76   QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS 135
            + L+LE+E      ++LT+  +EL    D      S+  + ++E           N+RLS
Sbjct: 461  RLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASKILKMEKE-----------NQRLS 504

Query: 136  QELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR----LEQEKELLH 191
            +++E L  ++ +  + L+       +L  +  +L+ +  +++   +R    LEQE E L+
Sbjct: 505  KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564

Query: 192  SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ 251
               + L    +    E      EK N+IL    +++    ++S++E +   +K   EH  
Sbjct: 565  QTVSSLRQRSQISA-EARVKDIEKENKILHE--SIKETSSKLSKIEFEKRQIKKELEHY- 620

Query: 252  KHVEDLLTKLKEAKEQQASMEEKFH-----NELNAHIKLSNLYKSAADDSEAKSNELTRA 306
                      KE  E+   +E + H     NEL    K++NL K   +  EA   E +  
Sbjct: 621  ----------KEKGERAEELENELHHLEKENEL-LQKKITNL-KITCEKIEALEQENSEL 668

Query: 307  VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
              E  KL K+  ++ K +   L  +E+   Q+++E LE    L + +E+     ++ K  
Sbjct: 669  ERENRKL-KKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLK--CASMKMA 721

Query: 367  GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
               L  +EL +         +++K   K TE      +  D      +EN+R+ K L+  
Sbjct: 722  QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD------IENQRLQKTLENS 775

Query: 427  VKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
             K+++     L+    E +  QK +  L +    + K +++L+++     +++S LE+D 
Sbjct: 776  NKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQLEKDK 831

Query: 487  RRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR----N 542
            +++E + K L QQ  +    LEE           V   ++   ++ +S+ +  Y+     
Sbjct: 832  KQLEKENKRLRQQAEIKDTTLEE---------NNVKIGNLEKENKTLSKEIGIYKESCVR 882

Query: 543  IEELQQQNQRL----------LVALRE-------------------------LGETRER- 566
            ++EL+++N+ L          LV LRE                         +G  +ER 
Sbjct: 883  LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942

Query: 567  --EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV 624
              +EQ T  S+   L+ KLES L +  ++   ++ ++  +++ + +   Y   L Q    
Sbjct: 943  LHDEQSTDDSRYKLLESKLESTLKKSLEI---KEEKIAALEARLEESTNYNQQLRQELKT 999

Query: 625  AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKK 684
                        +  +  +R    + V +  P+   ++    E++   ++L ++ +   +
Sbjct: 1000 V---------KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050

Query: 685  EKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHE 744
             +  N  +Q E+ + L+ Q+  L +QN  +  Q+    ++   LQ+       + T+L  
Sbjct: 1051 VERNNATLQAEK-QALKTQLKQLETQNNNLQAQILALQRQTVSLQE-------QNTTLQT 1102

Query: 745  RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAEN------------------LKK 786
            +N KL    Q +   +N+ +  L   N +L + +   EN                  L K
Sbjct: 1103 QNAKL----QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1158

Query: 787  EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLE 845
            + E L+L   R + + ESL+++         NL+     LE R     KQ+   Q+E LE
Sbjct: 1159 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK--GQLEDLE 1216

Query: 846  HEISHLKKKLENEVEQRHTLTRNL------DVQLLDTKRQLDTETNL----HLNTKELLK 895
              +   ++K+  E +   T+          + +L  T  QL  ET +    H N K LL 
Sbjct: 1217 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1276

Query: 896  NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERL 955
            N++ E   L+   S ++ Q                 + +D   ++L    E ++ LK  L
Sbjct: 1277 NSKLEQTRLEAEFSKLKEQY----------------QQLDITSTKLNNQCELLSQLKGNL 1320

Query: 956  KTSTSN-VEQYQAMV----TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
            +    + ++Q Q ++    T LE+++  +     E R+ I+ +L E    + +LE+K+M+
Sbjct: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID-KLNELRRQKEKLEEKIMD 1379

Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE----QQARR 1066
              K         RR    +  ++ +L K+   +  E Q++L    T   +     Q   +
Sbjct: 1380 QYKFYD--PSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437

Query: 1067 DCQEQAKI 1074
            D Q+ + +
Sbjct: 1438 DSQDSSSV 1445



 Score =  130 bits (327), Expect = 2e-29
 Identities = 189/899 (21%), Positives = 393/899 (43%), Gaps = 119/899 (13%)

Query: 819  LQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEV-----EQRHTLTRNLDVQL 873
            ++ IQG+    + +TK  +++ I+++ H   ++      EV     E    L +N+ + L
Sbjct: 142  IERIQGL----DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197

Query: 874  LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
               KR +D E + H  T   L   +  +  L    S+ +    S   +RT   Q  + E 
Sbjct: 198  ---KRLID-ERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE- 252

Query: 934  VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEE---SLNKEKQVTEEVRKNI 990
            + D  +++R+  +++ +  E+L      +EQ +  +  L++   +L  + +     R  +
Sbjct: 253  LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312

Query: 991  EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA 1050
            +  L+E A    +++K   EV + K+ L D     IE  + ++ ELK        E  + 
Sbjct: 313  DA-LREKA---VRVDKLESEVSRYKERLHD-----IEFYKARVEELK--------EDNQV 355

Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR 1110
            L    T L ++ +  R   ++    +E +N  + +  LH  ++E     ++++ ++    
Sbjct: 356  LLETKTMLEDQLEGTRARSDKLH-ELEKEN-LQLKAKLHDMEMER-DMDRKKIEELMEEN 412

Query: 1111 QHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
              LE   +++  + L     WE  +     E+S+          Q  L H+  E  S ++
Sbjct: 413  MTLEMAQKQSMDESLHL--GWELEQISRTSELSEA--------PQKSLGHEVNELTSSRL 462

Query: 1171 VASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVEL 1230
            +              L  E +S  + +E LR      E   ++    + E+ R  ++VE+
Sbjct: 463  L-------------KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509

Query: 1231 LEREL-QELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETN-KMLREEKERLEQ 1288
            LE E+ QE Q   N +     ++   M +  +L K  ET+    E   K+L +E E L Q
Sbjct: 510  LENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565

Query: 1289 DLQQM--------QAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
             +  +        +A+V+ +E +   L E+  E S K   ++ EK+ ++++++ +K + +
Sbjct: 566  TVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625

Query: 1341 HLVSQQKD-----PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNL 1395
                 + +      + E  +K ++  ++  ++I+ L +E   L+ E  +   +L + +NL
Sbjct: 626  RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685

Query: 1396 ---IQSLKEDLNKVRTEKETIQKDLDA------KIIDIQEKVKTITQVK----------- 1435
               ++SL+++ +++  E   +++++++      K+  +Q + K +   K           
Sbjct: 686  TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745

Query: 1436 ---KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
               K   R +  Y+ L  +  ++ +T   S+   Q+    +Q+++   +TL +   + K 
Sbjct: 746  ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKI 805

Query: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ--DLQDRTTQEEQLRQQITEKE 1550
               ++E L+K     E E   L++   QL+ E  RLRQ  +++D T +E  ++    EKE
Sbjct: 806  SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865

Query: 1551 EKT-RKAIVAAKSKIAHLAGVKDQLTKENEELKQR-----NGALDQQKDELDVRITALKS 1604
             KT  K I   K     L     +L KEN+EL +R        +  ++D +  ++     
Sbjct: 866  NKTLSKEIGIYKESCVRL----KELEKENKELVKRATIDIKTLVTLREDLVSEKLKT--Q 919

Query: 1605 QYEGRISRLERELRE---HQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIAS 1660
            Q    + +L  EL +   ++ER L       +   K+ E + + TLK +    E  IA+
Sbjct: 920  QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAA 978


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  177 bits (450), Expect = 8e-44
 Identities = 239/1195 (20%), Positives = 507/1195 (42%), Gaps = 161/1195 (13%)

Query: 389  VKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE-------IVKEVEAKAPILKRQR 441
            VKP +++T          ++LL  K +  ++   L+E       +++E    A  L+ + 
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900

Query: 442  EEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIR 501
            E +  A++  A L+ K ++  + +  L+   ++  +++ +L+ + ++M+  ++DL +Q+ 
Sbjct: 901  ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL- 959

Query: 502  VLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELG 561
                + EE     +  ++  + A I    E I            L+ QN + +   ++L 
Sbjct: 960  ----DEEEGARQKLQLEKVTAEAKIKKMEEEILL----------LEDQNSKFIKE-KKLM 1004

Query: 562  ETRERE------EQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYR 615
            E R  E      E+E  +  + +++ K E  +++LE+  K  +   Q ++   R+ D   
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD--- 1061

Query: 616  ILLSQTTGVA--IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI----EAK 669
                +TT +   I    + +D++ L    K+    Q          +    A+    E +
Sbjct: 1062 ---GETTDLQDQIAELQAQIDELKL-QLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117

Query: 670  AALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQ 729
            A + +LQE FE+ K  + + EK + +  E+L+   T+L       + Q +  +KR + + 
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177

Query: 730  DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKE 789
            +  +    E T  HE      A  Q   Q   T  ++L   +E+L  A+    NL+K K+
Sbjct: 1178 ELKKALEEE-TKNHE------AQIQDMRQRHATALEEL---SEQLEQAKRFKANLEKNKQ 1227

Query: 790  MLKLS------EVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843
             L+        EV++ QQ ++    +R +  L   +Q +   +   +   +  L+ +  K
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKK--LDAQVQELHAKVSEGD-RLRVELAEKASK 1284

Query: 844  LEHEISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
            L++E+ ++   LE   ++     ++   L+ QL DT+  L  ET   LN    ++  ++E
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE 1344

Query: 901  IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
              +L++                    Q   +E   +L  Q+   + Q+ D K+++     
Sbjct: 1345 KNSLQEQ-------------------QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLG 1385

Query: 961  NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ- 1019
             +E       SLEE+  K  +  E + +    RL+E A    +LEK    +++E  +L  
Sbjct: 1386 TIE-------SLEEAKKKLLKDAEALSQ----RLEEKALAYDKLEKTKNRLQQELDDLTV 1434

Query: 1020 --DDKRRAIESMEQQLSELKKTLS---SVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
              D +R+   ++E++  +  + L+   S+     E   RA      ++          + 
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494

Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
            A+EA+ ++ER+     AD+E L ++K+ V K       LE++ +  E Q+ E +   EE 
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV---HELEKSKRALEQQVEEMRTQLEE- 1550

Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE 1194
               L+DE+         LE   + +  Q E+                 ++   +E   ++
Sbjct: 1551 ---LEDELQATEDAKLRLEVNMQAMKAQFER-----------------DLQTRDEQNEEK 1590

Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
            + L I +    E E+ + R + A   + + +  ++L + E Q ++ +  A  E ++   K
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEVIKQLRK 1649

Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL 1314
              AQ ++  ++ E            R  ++ +    ++ + K++ LE +IL LQE  A  
Sbjct: 1650 LQAQMKDYQRELEEA----------RASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699

Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT------EEYRKLLSEKEVHTKRI 1368
                   + E+  L +++    +    L+ +++  +       EE  +  S  E+   R 
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759

Query: 1369 QQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ-----------KDL 1417
            ++ T ++  L AE+A   ++   + N  Q L+    +++ + + ++             L
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819

Query: 1418 DAKIIDIQEKV----KTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
            +AKI  ++E++    K      K+ RR + + +E+  Q    +E   + +  ++EQ    
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ----VEDERRHADQYKEQMEKA 1875

Query: 1474 Q-EMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
               M++LK  L +AE ++    +    LQ+ L +       L  +   L++ L R
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930



 Score =  174 bits (440), Expect = 1e-42
 Identities = 237/1220 (19%), Positives = 501/1220 (41%), Gaps = 192/1220 (15%)

Query: 89   LKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRL 148
            L  +T + +EL+   +  + ++ + T+ + ELE    ++ R +++L +E   L E ++  
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEKQTKVEGELE----EMERKHQQLLEEKNILAEQLQAE 899

Query: 149  NEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL 208
             E   E+   +  L  K  EL+     ++ R +  E+  ++L ++   +   ++   ++L
Sbjct: 900  TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959

Query: 209  LALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQ 268
                 E+     +L+      + ++ ++EE++  L+  N    K  + +  ++ E   Q 
Sbjct: 960  ----DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015

Query: 269  ASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL 328
            A  EEK  N      K+ N  +    D E +  +  +  +EL K  ++       +QD +
Sbjct: 1016 AEEEEKAKN----LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071

Query: 329  LEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKI 388
             E++   D+++ ++ +K   L+  L   +D    T  K   L                K+
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDD---ETLHKNNAL----------------KV 1112

Query: 389  VKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQ 448
            V+      EL     E Q+    EK    +  K   ++ +E+EA    LK + E+     
Sbjct: 1113 VR------ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA----LKTELEDTLDTT 1162

Query: 449  KAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE 508
             A   L  K EQ + E+++              LE + +  E Q++D+ Q+    L EL 
Sbjct: 1163 AAQQELRTKREQEVAELKK-------------ALEEETKNHEAQIQDMRQRHATALEELS 1209

Query: 509  EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE 568
            E      +   +   A++              +N + L+  N+ L   ++ L + +   E
Sbjct: 1210 EQ-----LEQAKRFKANLE-------------KNKQGLETDNKELACEVKVLQQVKAESE 1251

Query: 569  --QETTSSKITELQLKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
              ++   +++ EL  K+   +    EL +     Q+++  V +++ +        ++  G
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE--------AEKKG 1303

Query: 624  VAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYK 683
            +     A+SL+        +   T + +         E+ + +   + ++QL+E   + +
Sbjct: 1304 IKFAKDAASLES-------QLQDTQELLQE-------ETRQKLNLSSRIRQLEEEKNSLQ 1349

Query: 684  KEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLH 743
            +++ E E    E  + L++QV  L+SQ      ++D      E L++  +   ++  +L 
Sbjct: 1350 EQQEEEE----EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 744  ERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEML-------KLSEV 796
            +R ++      K E+  N + Q+L      L      A NL+K+++         K    
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 797  RLSQQRESLLAEQRGQNLLLTNL-QTIQGILE------------RSETETKQRLSSQIEK 843
            R +++R+   AE R +     +L + ++  LE            R++ E        + K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525

Query: 844  LEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT 903
              HE+   K+ LE +VE+  T    L+ +L  T+   D +  L +N + +    ++++ T
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATE---DAKLRLEVNMQAMKAQFERDLQT 1582

Query: 904  LKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE 963
              +                       N+E    L+ Q+R+ E ++ D +++   + ++ +
Sbjct: 1583 RDE----------------------QNEEKKRLLIKQVRELEAELEDERKQRALAVASKK 1620

Query: 964  QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKR 1023
            + +  +  LE  +    +  +EV K +               +KL    K+ Q   ++ R
Sbjct: 1621 KMEIDLKDLEAQIEAANKARDEVIKQL---------------RKLQAQMKDYQRELEEAR 1665

Query: 1024 RAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNK-- 1081
             + + +  Q  E +K L S++ E+   LQ      S+E+  R   QE+ ++A E  N   
Sbjct: 1666 ASRDEIFAQSKESEKKLKSLEAEI---LQLQEELASSERARRHAEQERDELADEITNSAS 1722

Query: 1082 -----YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
                  + +  L A   +  +  +E+ S M  +     +TT + ++   E  A   ER  
Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA---ERSA 1779

Query: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD------KVVASVKEGVQGPLNVSLSEEG 1190
              K + ++     + LE+QN+ L  ++++L        K   S  E   G L   L +E 
Sbjct: 1780 AQKSDNAR-----QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834

Query: 1191 KSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQRVELLERELQELQDSL-NAERE 1247
            K +    +++R  R EK++ E   +V   +  + +Y++++E     +++L+  L  AE E
Sbjct: 1835 KERAAANKLVR--RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892

Query: 1248 KVQVTAKTMAQHEELMKKTE 1267
              +  A       EL   TE
Sbjct: 1893 ATRANASRRKLQRELDDATE 1912



 Score =  173 bits (438), Expect = 2e-42
 Identities = 233/1170 (19%), Positives = 488/1170 (41%), Gaps = 146/1170 (12%)

Query: 528  SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGE-TREREEQETTSS---KITELQLKL 583
            S+ +V+ ++  +Y  +   Q    R+   ++ L + TR+ EE +       K+ E Q K+
Sbjct: 814  SALKVLQRNCAAYLKLRHWQWW--RVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKV 871

Query: 584  ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK 643
            E  L E+E     R+HQ  L +         + +L++       L A + +  +  +  K
Sbjct: 872  EGELEEME-----RKHQQLLEE---------KNILAEQLQAETELFAEAEEMRARLAAKK 917

Query: 644  RPSTSQTVSTPAPVPVIESTEAI---EAKAALKQLQEIFENYKKEKAENEKIQNEQ---- 696
            +          + V   E    I   E K     +Q++ E   +E+   +K+Q E+    
Sbjct: 918  QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977

Query: 697  --LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
              ++K++E++  L  QN+K         K  ++++D +     ++    E+ + L     
Sbjct: 978  AKIKKMEEEILLLEDQNSKFI-------KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030

Query: 755  KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
            KQE +I+ +        E+L   E   + L+K K  L      L  Q   L A+     L
Sbjct: 1031 KQEVMISDL-------EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083

Query: 815  LLTNLQT-IQGILERSETET--KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RN 868
             L   +  +QG L R + ET  K      + +L+ +I+ L++  E+E   R+      R+
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143

Query: 869  LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQP 928
            L  +L   K +L+   +     +EL    ++E+A LK+ L                    
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE------------------ 1185

Query: 929  SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRK 988
                       + +  E Q+ D+++R  T+   + +        + +L K KQ  E   K
Sbjct: 1186 -----------ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234

Query: 989  NIEVRLKESAEFQTQLEKKLMEVEKEKQELQ----DDKRRAIESMEQQLSELKKTLSSVQ 1044
             +   +K   + + + E K  +++ + QEL     +  R  +E + ++ S+L+  L +V 
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE-LAEKASKLQNELDNVS 1293

Query: 1045 NEVQEALQR----ASTALSNEQQAR-------RDCQEQAKIAVEAQNKYERELMLHAADV 1093
              ++EA ++    A  A S E Q +        + +++  ++   +   E +  L     
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353

Query: 1094 EALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD------EVSKCVC 1147
            E  +A K    ++ +++  L +T +K +  L   ++  E ++++LKD       + +   
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413

Query: 1148 RCEDLEKQNRLLHDQIEKLS-----DKVVASVKEGVQGPLNVSLSEEGKSQEQILEI--- 1199
              + LEK    L  +++ L+      + VAS  E  Q   +  L+EE     +  E    
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473

Query: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQ------------------ELQDS 1241
                 REKE        A  E+L  ++  E   ++L+                  EL+ S
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS 1533

Query: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM-QAKVRKL 1300
              A  ++V+     + + E+ ++ TE   + +E N  ++  K + E+DLQ   +    K 
Sbjct: 1534 KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVN--MQAMKAQFERDLQTRDEQNEEKK 1591

Query: 1301 ELDILPLQEANAELSEKS---GMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKL 1357
             L I  ++E  AEL ++     +  A KK +E D+K  +A+ +   ++ +D   ++ RKL
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE-AANKARDEVIKQLRKL 1650

Query: 1358 LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL 1417
             ++ + + + +++       + A+   S   L + +  I  L+E+L      +   +++ 
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710

Query: 1418 DAKIIDIQE----KVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
            D    +I      K   + + +++  R     EEL+ +Q  +   + +      +     
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770

Query: 1474 QEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ-LQSELSRLRQDL 1532
             E+   +    +++   + LE Q + L+  L E E   ++  + T+  L++++ +L + L
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQL 1830

Query: 1533 QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQK 1592
            +    +     + +   E+K ++  +  + +  H    K+Q+ K N  +KQ    L++ +
Sbjct: 1831 EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890

Query: 1593 DELDVRITALKSQYEGRISRLERELREHQE 1622
            +E      A ++    R  +L+REL +  E
Sbjct: 1891 EE------ATRANASRR--KLQRELDDATE 1912



 Score =  169 bits (427), Expect = 4e-41
 Identities = 234/1126 (20%), Positives = 488/1126 (43%), Gaps = 132/1126 (11%)

Query: 6    QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
            QQ+LE  E N L + +Q + E F     +E + ++ R    K E E+   ++E R+   +
Sbjct: 883  QQLLE--EKNILAEQLQAETELF-----AEAEEMRARLAAKKQELEEILHDLESRVEEEE 935

Query: 66   ERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDR----NIAIQSQFTRTKEE-- 119
            ER        Q L+ E +K+   ++ L E+  E E A+ +     +  +++  + +EE  
Sbjct: 936  ERN-------QILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEIL 988

Query: 120  -LEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
             LE +    I+  + +   +   +  +    EK K     + + ++ + +L+      + 
Sbjct: 989  LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048

Query: 179  REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
              + LE+ K  L  + T L                   ++I EL+  ++  K ++++ EE
Sbjct: 1049 TRQELEKAKRKLDGETTDLQ------------------DQIAELQAQIDELKLQLAKKEE 1090

Query: 239  QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
            ++ G     +    H  + L  ++E + Q A ++E F +E  +  K     +  +++ EA
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150

Query: 299  KSNEL------TRAVEELH-KLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK 351
               EL      T A +EL  K  +E  E  KA+++     E     M +     +  L +
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE 1210

Query: 352  ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
            +LE A    +  ++     +++ L   +   A   K+++     +E     ++ Q Q L 
Sbjct: 1211 QLEQAKRFKANLEK-----NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265

Query: 412  EKL-ENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQR-LQ 469
             K+ E  R+   L E   +++ +   +    EE E+     A  +  LE  +++ Q  LQ
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325

Query: 470  EDT-DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            E+T  K N  S +     R++E +   L +Q      E EEAR N + +      + ++ 
Sbjct: 1326 EETRQKLNLSSRI-----RQLEEEKNSLQEQQE----EEEEARKN-LEKQVLALQSQLAD 1375

Query: 529  SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALT 588
            + + +   L     IE L++  ++LL     L  ++  EE+     K+ + + +L+    
Sbjct: 1376 TKKKVDDDL---GTIESLEEAKKKLLKDAEAL--SQRLEEKALAYDKLEKTKNRLQQ--- 1427

Query: 589  ELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTS 648
            EL+ L     HQ Q+  ++ +++  +  LL++   ++    A   ++   A    R   +
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS----ARYAEERDRAEAEAREKET 1483

Query: 649  QTVSTPAPVPVIESTEAIEAKAAL----KQLQEIFENYKKEKAENEKIQNEQLEK----L 700
            + +S    +      EA+EAK       KQL+   E+    K +  K  +E LEK    L
Sbjct: 1484 KALSLARAL-----EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRAL 1537

Query: 701  QEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEG----YRREITSLHERNQKLTATTQKQ 756
            ++QV ++R+Q  ++  +L         L+ N++     + R++ +  E+N++      KQ
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597

Query: 757  EQIINTMTQDLRGANEKLAVA-----EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
             + +    +D R     LAVA     E+  ++L+ + E    +   + +Q   L A+ + 
Sbjct: 1598 VRELEAELEDER-KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656

Query: 812  QNLLLTNLQTIQGILERSETETKQRLSS---QIEKLEHEISHLKKKLENEVEQRHTLTRN 868
                L   +  +  +     E++++L S   +I +L+ E++  ++   +  ++R  L   
Sbjct: 1657 YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADE 1716

Query: 869  L------DVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQR 922
            +         LLD KR+L+         +E L+  Q  +  L        +QV + +++ 
Sbjct: 1717 ITNSASGKSALLDEKRRLEARI---AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAEL 1773

Query: 923  TGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNK-EK 980
              +   + K D     +  +Q E Q  +LK +L+     V+ +++A +++LE  + + E+
Sbjct: 1774 AAERSAAQKSD-----NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828

Query: 981  QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
            Q+ +E ++          +   + EKKL E+  +     +D+RR  +  ++Q+ +    +
Sbjct: 1829 QLEQEAKERAAAN-----KLVRRTEKKLKEIFMQ----VEDERRHADQYKEQMEKANARM 1879

Query: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
              ++ +++EA + A+ A      +RR  Q +   A EA     RE+
Sbjct: 1880 KQLKRQLEEAEEEATRA----NASRRKLQRELDDATEANEGLSREV 1921



 Score =  155 bits (392), Expect = 4e-37
 Identities = 234/1194 (19%), Positives = 496/1194 (41%), Gaps = 167/1194 (13%)

Query: 196  WLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE 255
            W    + TK   LL + R++          L+ K EE+ +++E+   ++   E +++  +
Sbjct: 832  WQWWRVFTKVKPLLQVTRQEEE--------LQAKDEELLKVKEKQTKVEGELEEMERKHQ 883

Query: 256  DLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLK 315
             LL +     EQ  +  E F        +L+           AK  EL   + +L   ++
Sbjct: 884  QLLEEKNILAEQLQAETELFAEAEEMRARLA-----------AKKQELEEILHDLESRVE 932

Query: 316  EAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK-ELENANDLLSATKRKGAILSEEE 374
            E  E N+ +Q+   +++     +E+++ E+ G  +K +LE                    
Sbjct: 933  EEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT----------------- 975

Query: 375  LAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKA 434
                     A AKI K               ++++LL + +N   +K++ E  K +E + 
Sbjct: 976  ---------AEAKIKK--------------MEEEILLLEDQN---SKFIKE-KKLMEDRI 1008

Query: 435  PILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVK 494
                 Q  E E   K +A +  K E  + +   L+E   K  K    LE+  R+++ +  
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGETT 1065

Query: 495  DLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLL 554
            DL  QI  L  +++E +     ++EE+  A      E + ++  + + + ELQ Q   L 
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNN-ALKVVRELQAQIAELQ 1124

Query: 555  V------ALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
                   A R   E ++R+  E   +  TEL+  L++   + E   K  Q   +L  ++ 
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184

Query: 609  RQRDMYRILLSQTTGVAIPLHASSLDDVS---------LASTPKRPSTSQTVSTP--APV 657
             +   +   +          HA++L+++S          A+  K     +T +      V
Sbjct: 1185 EETKNHEAQIQDMR----QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240

Query: 658  PVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ 717
             V++  +A E++   K+L    +    + +E ++++ E    L E+ + L+++   +ST 
Sbjct: 1241 KVLQQVKA-ESEHKRKKLDAQVQELHAKVSEGDRLRVE----LAEKASKLQNELDNVSTL 1295

Query: 718  LDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777
            L+ A K+      +      ++    E  Q+ T         I  + ++     E+    
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355

Query: 778  EVRAENLKKE----KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSET-- 831
            E   +NL+K+    +  L  ++ ++     ++ + +  +  LL + + +   LE      
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415

Query: 832  ----ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLH 887
                +TK RL  +++ L  ++ H ++   N  +++    + L  +   + R  +      
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 888  LNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ 947
               +E      KE   L    +  E   A +  +R  K     + D++DL+S      + 
Sbjct: 1476 AEARE------KETKALSLARALEEALEAKEEFERQNK---QLRADMEDLMSSKDDVGKN 1526

Query: 948  VNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKE-SAEFQTQLEK 1006
            V++L++  +     VE+   M T LEE L  E Q TE+ +  +EV ++   A+F+  L+ 
Sbjct: 1527 VHELEKSKRALEQQVEE---MRTQLEE-LEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582

Query: 1007 KLMEVEKEKQ-----------ELQDD-KRRAI-----ESMEQQLSELKKTLSSVQNEVQE 1049
            +  + E++K+           EL+D+ K+RA+     + ME  L +L+  + +      E
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642

Query: 1050 ALQRASTALSNEQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMA 1107
             +++     +  +  +R+ +E   ++  + AQ+K E E  L + + E LQ  +E+++   
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK-ESEKKLKSLEAEILQL-QEELASSE 1700

Query: 1108 SVRQHLEETTQKAESQLLEC---KASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIE 1164
              R+H E+   +   ++      K++  + +R L+  +++     E+ +    LL+D+  
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760

Query: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE-KEIAETRFEVAQVESLR 1223
            K + +V           LN  L+ E  + ++     + + R+ KE+     E+      +
Sbjct: 1761 KTTLQV---------DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811

Query: 1224 YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT---------------ET 1268
            ++  +  LE ++ +L++ L  E ++     K + + E+ +K+                E 
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ 1871

Query: 1269 MNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQ 1322
            M       K L+ + E  E++  +  A  RKL+ ++    EAN  LS +   L+
Sbjct: 1872 MEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925



 Score =  128 bits (322), Expect = 6e-29
 Identities = 188/828 (22%), Positives = 345/828 (41%), Gaps = 149/828 (17%)

Query: 934  VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEV- 992
            V  L+   RQ EE     +E LK      E+   +   LEE   K +Q+ EE  KNI   
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVK----EKQTKVEGELEEMERKHQQLLEE--KNILAE 894

Query: 993  RLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQ 1052
            +L+   E   + E+    +  +KQEL++     +ES  ++  E  + L + + ++Q  +Q
Sbjct: 895  QLQAETELFAEAEEMRARLAAKKQELEEILHD-LESRVEEEEERNQILQNEKKKMQAHIQ 953

Query: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERE--LMLHAADVEALQAAKEQVSKMASVR 1110
                 L  E+ AR+  Q + K+  EA+ K   E  L+L   + + ++  K    ++A   
Sbjct: 954  DLEEQLDEEEGARQKLQLE-KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012

Query: 1111 QHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
              L E  +KA++ L + +   E     L++ + K     ++LEK  R L  +   L D++
Sbjct: 1013 SQLAEEEEKAKN-LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071

Query: 1171 -------------VASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVA 1217
                         +A  +E +QG L     +E   +   L+++R +  + +IAE + +  
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARG-DDETLHKNNALKVVREL--QAQIAELQEDFE 1128

Query: 1218 QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNK 1277
              ++ R +      E++ ++L + L A + +++ T  T A  +EL  K E    V E  K
Sbjct: 1129 SEKASRNKA-----EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE--QEVAELKK 1181

Query: 1278 MLREEKERLEQDLQQMQAK----VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVK 1333
             L EE +  E  +Q M+ +    + +L   +   +   A L +    L+ + K L  +VK
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241

Query: 1334 RWKARNQHLVSQQKDPDTEEYRKLLSEK--EVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
                     V QQ   ++E  RK L  +  E+H K       E  RL+ E+A   + L N
Sbjct: 1242 ---------VLQQVKAESEHKRKKLDAQVQELHAK-----VSEGDRLRVELAEKASKLQN 1287

Query: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
              + + +L E+  K   +       L++++ D QE ++  T+ K        Q EE K  
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347

Query: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
              +  E   ++  + ++Q +++Q   +L +T  + +    ++ES  E  +K L + E  +
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQS--QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 1512 RNLQEQTV---QLQSELSRLRQDLQDRTTQEEQLRQQIT--------------------- 1547
            + L+E+ +   +L+   +RL+Q+L D T   +  RQ  +                     
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 1548 -----------EKEEKTRKAIVAAKS--------------------KIAHLAGVKDQLTK 1576
                       E  EK  KA+  A++                     +  L   KD + K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525

Query: 1577 ENEELKQRNGALDQQKDE---------------------LDVRITALKSQYEGRISRLER 1615
               EL++   AL+QQ +E                     L+V + A+K+Q+         
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF--------- 1576

Query: 1616 ELREHQERHLEQRDEPQEPSNK-VPEQQRQITLKTTPASGERGIASTS 1662
                  ER L+ RDE  E   + + +Q R++  +      +R +A  S
Sbjct: 1577 ------ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 126/557 (22%), Positives = 239/557 (42%), Gaps = 69/557 (12%)

Query: 2    AAVLQQVLERTEL--NKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFE--- 56
            A  L Q LE   L  +KL K+ +N+L++ L D   ++D    R     +E +Q+ F+   
Sbjct: 1401 AEALSQRLEEKALAYDKLEKT-KNRLQQELDDLTVDLD--HQRQVASNLEKKQKKFDQLL 1457

Query: 57   -----IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQS 111
                 I  R +  ++R   E RE ++  L L +    L+   E  +E E    +  A   
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADME 1514

Query: 112  QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
                +K+++     +L ++   L Q++E +   ++ L ++L+ +   K  L++ +  ++A
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 172  S-DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDE-LLALGREKGNEILELKCNLENK 229
              +  ++ R+++ E++K LL  Q   L  EL+ +  +  LA+  +K  EI          
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI---------- 1624

Query: 230  KEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLK----EAKEQQASMEEKFHNELNAHIKL 285
              ++  LE Q+     + + + K +  L  ++K    E +E +AS +E F     +  KL
Sbjct: 1625 --DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682

Query: 286  SNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQM--EKEML 343
             +L        EA+  +L   +    +  + A +    + D +      K  +  EK  L
Sbjct: 1683 KSL--------EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRL 1734

Query: 344  E-KIGRLEKELENAN---DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
            E +I +LE+ELE      +LL+   RK  +  +   A ++   +A  K      +L    
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL---- 1790

Query: 400  NAYVETQDQLLLEKLENKR--INKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVK 457
                E Q++ L  KL+     +       +  +EAK   L+ Q E+  + + A   L  +
Sbjct: 1791 ----ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846

Query: 458  LEQAMKEI-----------QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLME 506
             E+ +KEI            + +E  +KAN +   L+R     E +    +   R L  E
Sbjct: 1847 TEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE 1906

Query: 507  LEEARGNHVIRDEEVSS 523
            L++A   +     EVS+
Sbjct: 1907 LDDATEANEGLSREVST 1923



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 88/400 (22%), Positives = 185/400 (46%), Gaps = 47/400 (11%)

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
            KV+   +   Q EEL  K E +  V       +E++ ++E +L++M+ K ++L      L
Sbjct: 840  KVKPLLQVTRQEEELQAKDEELLKV-------KEKQTKVEGELEEMERKHQQL------L 886

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
            +E N  L+E+   LQAE +L  E                     EE R  L+ K+   + 
Sbjct: 887  EEKNI-LAEQ---LQAETELFAE--------------------AEEMRARLAAKK---QE 919

Query: 1368 IQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK 1427
            ++++  ++     E    N  L N +  +Q+  +DL +   E+E  ++ L  + +  + K
Sbjct: 920  LEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979

Query: 1428 VKTITQVKKIGRRYKTQY-EELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486
            +K + +   +     +++ +E K  +D++ E S+Q + + ++     +   + +  ++  
Sbjct: 980  IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039

Query: 1487 ETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546
            E + K  E   + L+K   + + E  +LQ+Q  +LQ+++  L+  L     +EE+L+  +
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL---AKKEEELQGAL 1096

Query: 1547 TEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQY 1606
               +++T     A K  +  L     +L ++ E  K      ++QK +L   + ALK++ 
Sbjct: 1097 ARGDDETLHKNNALK-VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155

Query: 1607 EGRI--SRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
            E  +  +  ++ELR  +E+ + +  +  E   K  E Q Q
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 84/399 (21%), Positives = 170/399 (42%), Gaps = 43/399 (10%)

Query: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
            L+  L+ TE  KL   V  +  K  A  + ++     ++E+ K    +Q  E+E  L   
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMK--AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608

Query: 65   QERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQ-FTRTKEELEAE 123
            +++        + + ++L+ L  Q++A  +   E+ I Q R +  Q + + R  EE  A 
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV-IKQLRKLQAQMKDYQRELEEARAS 1667

Query: 124  KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL------QASDVSVK 177
            + ++   ++   ++L+ L  ++ +L E+L  S   +   + + DEL       AS  S  
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727

Query: 178  YREKR--------LEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGNEILELK 223
              EKR        LE+E E   S    LN   +  T ++      LA  R    +    +
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787

Query: 224  CNLENKKEEV-SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME---------- 272
              LE + +E+ ++L+E    +K+  +     +E  + +L+E  EQ+A             
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847

Query: 273  EKFHNELNAHI----KLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL 328
            EK   E+   +    + ++ YK   + + A+  +L R +EE  +    A  + + +Q  L
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907

Query: 329  LEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367
             +  ++ + + +E    +  L+  L     +  ++ R G
Sbjct: 1908 DDATEANEGLSRE----VSTLKNRLRRGGPISFSSSRSG 1942



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 40/168 (23%), Positives = 81/168 (48%), Gaps = 13/168 (7%)

Query: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHE---KFKVESEQQYFEIEKRLSHSQER 67
            + +L +L  +V++K +  ++  +++I  L+ + E   K +  + +     EK+L     +
Sbjct: 1798 KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ 1857

Query: 68   LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
            + +E R     + ++EK N ++K L  + +E E    R  A       ++ +L+ E  D 
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA-------SRRKLQRELDDA 1910

Query: 128  IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD--ELQASD 173
               NE LS+E+  L   ++R    +  S++  G  QL L+   L+ SD
Sbjct: 1911 TEANEGLSREVSTLKNRLRR-GGPISFSSSRSGRRQLHLEGASLELSD 1957


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  177 bits (448), Expect = 1e-43
 Identities = 348/1653 (21%), Positives = 667/1653 (40%), Gaps = 241/1653 (14%)

Query: 243  LKTSNEHLQKH---VEDLLTKLKEAKEQQASMEEKFHNELNAHIKLS--NLYKSAADDSE 297
            L+  N+ LQ+    VEDLL + +  +++ A         L   ++L    L         
Sbjct: 79   LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138

Query: 298  AKSNELTRAVEELHKLLK------EAGEANKA-----IQDHLLEVEQSKDQMEKEMLEKI 346
             +S EL R ++E     +      + G+  +A     +Q  +L+ ++   ++E+++LE+ 
Sbjct: 139  RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198

Query: 347  GRLE----KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAY 402
            G LE    ++ E++ DL SA  R    L EE+       +A++A++    M   +L  A 
Sbjct: 199  GELEQQRLRDTEHSQDLESALIR----LEEEQ-----QRSASLAQV--NAMLREQLDQA- 246

Query: 403  VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
              + +Q L E +  +++        KE+E +    +R+ E +        S  + L + +
Sbjct: 247  -GSANQALSEDI--RKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQV 303

Query: 463  KEIQRLQEDTDKANKQSSV-----LERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIR 517
               +RL  +     ++  +     L R +R ++     LS  +R     L E+R    + 
Sbjct: 304  VGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR-----LAESRAEAALE 358

Query: 518  DEEVSSADISSSSEVISQHLVSYRNIEELQQQNQR----LLVALRELGETREREEQETTS 573
             + +  A +    E +   ++  +++ + Q Q+      L   + ELG   +R E++   
Sbjct: 359  KQALLQAQLE---EQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLE 415

Query: 574  SKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQ---RDMYRILLS------QTTGV 624
                ++   L   L  LE LR   Q  ++  D    Q   RD+ + +LS      Q +G 
Sbjct: 416  KD--QVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGS 473

Query: 625  AIPLHASS-----LDDVSLASTPKRPSTSQTVST---PAPVPVIESTEAIEAKAALKQLQ 676
                 AS+     L      S P+R S  +  S    P+P     ST A+   A  K+  
Sbjct: 474  ERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQL 533

Query: 677  EIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYR 736
            ++ +   + +A  +      L  L++Q++D  S+   +  QL     + +      E  +
Sbjct: 534  QVQDMRGRYEASQDL-----LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQ 588

Query: 737  REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
            RE+  L   N+ L+              ++       L VA+ +AE L++E+E L+ ++ 
Sbjct: 589  REVQRLRSANELLS--------------REKSNLAHSLQVAQQQAEELRQEREKLQAAQE 634

Query: 797  RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE 856
             L +QR+ L  EQ              G   R E E   R   Q+E+LE + S L K+L 
Sbjct: 635  ELRRQRDRLEEEQED--------AVQDGARVRRELERSHR---QLEQLEGKRSVLAKEL- 682

Query: 857  NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVA 916
              VE R  L+R                                  ATL++ +   E    
Sbjct: 683  --VEVREALSR----------------------------------ATLQRDMLQAEKAEV 706

Query: 917  SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
            +++  +   G    + +++  +++LR  E  + D   +L     ++ Q +  +  L   L
Sbjct: 707  AEALTKAEAG----RVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762

Query: 977  NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKR---RAIESMEQQL 1033
             +EK   +  ++  E     + E Q +LE+  +E E  +Q L+   R   +A E++EQQL
Sbjct: 763  EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822

Query: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
              L+   S +Q ++ +  ++ S      +QARR+ Q Q +    A  + E     HA   
Sbjct: 823  PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882

Query: 1094 EALQAAKEQVSKMASVRQHLEETTQKAESQLLECK---ASWEERERMLKDEVSKCVCRCE 1150
              L AA+ +   ++     L    +  E  L E +   A  E R   L+ E    +   E
Sbjct: 883  VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942

Query: 1151 DLEKQNRLLHDQI-----------EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
             L  +   L  QI           E ++ K+V + +E        SL E+  + E   E 
Sbjct: 943  TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREA-----QASLREQRAAHE---ED 994

Query: 1200 LRFIRREKEIA--ETRFEVAQVESLRYRQRVELLER------ELQELQDSLNAEREKVQV 1251
            L+ ++REKE A  E   E AQ++S   R++ ELL R      EL E   +L  ER++  +
Sbjct: 995  LQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL 1054

Query: 1252 TAKTMAQHEELMKKTE--------------TMNVVMETNKMLREEKERLEQDLQQMQAKV 1297
             A++  Q    +K++E                 + +E  +  R+ + R EQD   + A  
Sbjct: 1055 LAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT 1114

Query: 1298 RKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK--DPDTEEYR 1355
             +L       +EA A  +++   LQ + + L +         + L +Q +  +   +  R
Sbjct: 1115 SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLR 1174

Query: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK 1415
            + L E +   +  Q+  E   +   E+ RS       +  ++   E+L     + E+ + 
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI 1234

Query: 1416 DLDAKIIDIQEKVKTITQVK-KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
             L     D ++K+  + + +  +G+    +  EL+    +V  +  ++           +
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGK----EAGELRTGLQEVERSRLEAR----------R 1280

Query: 1475 EMQELKETLNQAETKSKSLESQVENLQKTL-----SEKET--EARNLQEQTVQLQSELSR 1527
            E+QEL+  +   ++++  L  ++  LQ  L     +EKE+  E   L+++ ++ ++ L  
Sbjct: 1281 ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV 1340

Query: 1528 LRQDLQ--DRTTQEEQLRQQITEKE--EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQ 1583
            +RQ+LQ   R  QE++   +  E+       +A    K ++ H  G++ +L     E  +
Sbjct: 1341 MRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAE 1400

Query: 1584 ----------RNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
                      R   L+ +   ++V+  A ++Q  G  S L R L   +      R  P  
Sbjct: 1401 LGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460

Query: 1634 PSNKVPEQ------QRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMA 1687
            P+   P +          TL+ +P S        + P + ++ P  V     +      +
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRS 1520

Query: 1688 GNKS-----TPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQS-EGPVEHVPV- 1740
              +      T  +++   +        + T  A  +     ES+EA +S +G +  V   
Sbjct: 1521 AQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAE 1580

Query: 1741 FGSTSGSVRSTSPNVQPSISQPILTVQQQTQAT 1773
                  SVR +    + ++ Q + T+++  QAT
Sbjct: 1581 LALQEESVRRSERERRATLDQ-VATLERSLQAT 1612



 Score =  174 bits (442), Expect = 7e-43
 Identities = 336/1556 (21%), Positives = 629/1556 (40%), Gaps = 189/1556 (12%)

Query: 25   LEKFLADQQSEIDGLKGRHEKF--KVESEQQYFEIEKRLSHSQERLVNE--TRECQSLRL 80
            L K L+D +SE   L+ + ++   K +   Q  E  +R    + R  NE  +RE  +L  
Sbjct: 552  LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR-EVQRLRSANELLSREKSNLAH 610

Query: 81   ELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
             L+    Q + L ++ ++L+ AQ+       +  R ++ LE E+ D ++   R+ +ELE 
Sbjct: 611  SLQVAQQQAEELRQEREKLQAAQE-------ELRRQRDRLEEEQEDAVQDGARVRRELER 663

Query: 141  LTEDVKRLNEK-------LKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQ 193
                +++L  K       L E         L+ D LQA    V     + E  +  L   
Sbjct: 664  SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS 723

Query: 194  NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKH 253
             T L  E  +  D L        +++  L  +L   K +++RL  Q+   K++ +  Q+ 
Sbjct: 724  MTKLRAEEASLQDSL--------SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQ 775

Query: 254  VEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL 313
             E   T    A+E+Q  +EE    +  A   L    + A    EA   +L     E  +L
Sbjct: 776  AEQEAT---VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQL 832

Query: 314  LKEAGEANKAIQDHLLEVEQSKDQMEK--EMLEKIGR----LEKELENANDLLSATKRKG 367
             ++  + ++ +     E+EQ++ + ++  E LE+  R    L KE       L A +R+G
Sbjct: 833  QEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892

Query: 368  AILSEEELAAMSPTAAAVAKIVKPGMKLTEL--YNAYVETQDQLLLEKLENKRINKYLDE 425
              LSEE         A    + +   +L +L      +E + Q LL  L  + +   L  
Sbjct: 893  RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL--LAKETLTGELAG 950

Query: 426  IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485
            + +++ A            E+A      ++ KL QA +E Q    +   A+++   L+R 
Sbjct: 951  LRQQIIA----------TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEED--LQRL 998

Query: 486  NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545
             R  E   ++L  +   L  +L+        R++E   A + +  E +S+ + + +    
Sbjct: 999  QREKEAAWRELEAERAQLQSQLQ--------REQEELLARLEAEKEELSEEIAALQ---- 1046

Query: 546  LQQQNQRLLVALRELGETREREEQETT--SSKITELQLKLESALTELE-QLRKSRQHQMQ 602
             Q++++ LL+A  E  +    +E E T  S K+   +  L +   E+E Q R ++  Q Q
Sbjct: 1047 -QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105

Query: 603  LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
               ++       R L +Q    A    A+   +V       R    Q  S          
Sbjct: 1106 DRSTVNALTSELRDLRAQREEAA----AAHAQEVRRLQEQARDLGKQRDSC--------L 1153

Query: 663  TEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFAS 722
             EA E +  L+ L++  +  ++E  E ++   E  E  + Q    R +  ++   L   +
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ----RQEAGELRRSLGEGA 1209

Query: 723  KRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAE 782
            K  E L+ + E  R  +         L    + +EQ +  + +      ++        +
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269

Query: 783  NLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET-------KQ 835
             +++ +   +     L +Q + L +E       L  LQ    + ER+E E+       +Q
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQ 1329

Query: 836  RL---SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT----KRQLDTETNLHL 888
            RL    + +E +  E+   ++KL+ +  +  T  R L   L +     K+QLD    L L
Sbjct: 1330 RLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLEL 1389

Query: 889  NTKEL----------LKNAQKEIATLKQHLSNMEVQVASQSSQ--------RTGKG---- 926
              +            L  A+     L+  L+ +EVQ  +  +Q        R G G    
Sbjct: 1390 KLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRA 1449

Query: 927  -----QPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS-LEESLNKE- 979
                 +P       D  ++   + E +N     L+ S  +        TS     L+ E 
Sbjct: 1450 PSPAPRPVPGSPARDAPAE--GSGEGLNS-PSTLECSPGSQPPSPGPATSPASPDLDPEA 1506

Query: 980  -KQVTEEVRKNIEVRLKESAEFQTQ---LEKKLMEVEKEKQELQDDKR---RAIESMEQQ 1032
             +    E  + +    +E  E +TQ   L ++L E+E E+       R   +A+   E+ 
Sbjct: 1507 VRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566

Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAAD 1092
               +   LS VQ E+  ALQ  S   S  ++ RR   +Q      +    E EL    A 
Sbjct: 1567 RRSVDGRLSGVQAEL--ALQEESVRRS--ERERRATLDQVATLERSLQATESEL---RAS 1619

Query: 1093 VEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDL 1152
             E +   K   +K+   ++ L+E    +ES+ ++     E + R L+ E+ +      D 
Sbjct: 1620 QEKISKMKANETKLEGDKRRLKEVLDASESRTVKL----ELQRRSLEGELQRSRLGLSDR 1675

Query: 1153 EKQNRLLHDQIEKLSDKVVAS-VKEG----VQGPLNVSLSEEGKSQEQILEILRFIRREK 1207
            E Q + L D+++ L  +V  S VK G        LN +L++  +S+  + + +R +    
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735

Query: 1208 EIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE 1267
              +       + ++L  ++ +   E + Q LQ+ L+A R   Q  ++   Q   L ++ +
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAAR---QALSEARKQSSSLGEQVQ 1792

Query: 1268 TMNVVMETNKMLREEKE----RLEQDLQQMQA-------KVRKLELDILPLQEANAELSE 1316
            T+   +   ++ R E E    +L + L+Q Q         V+KL+ +   LQE    L  
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852

Query: 1317 KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376
                L+AEK+ +E    R +   +  V+ ++  D  E  KL S ++       +L+ E G
Sbjct: 1853 ALAQLEAEKREVERSALRLE---KDRVALRRTLDKVEREKLRSHEDT-----VRLSAEKG 1904

Query: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK 1436
            RL   +  +   L   Q  IQ L+  +  +       Q ++DA+    Q++++   +V++
Sbjct: 1905 RLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ----QQQLELQQEVER 1960

Query: 1437 IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
            +           +AQ ++ +E  A+     Q      +++  LK  L Q   +S +
Sbjct: 1961 L--------RSAQAQTERTLE--ARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006



 Score =  160 bits (406), Expect = 1e-38
 Identities = 283/1543 (18%), Positives = 615/1543 (39%), Gaps = 219/1543 (14%)

Query: 250  LQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE---LTRA 306
            L+K + D  ++ +  +EQ   + +K    + AH       +     +E  S E   L  +
Sbjct: 552  LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHS 611

Query: 307  VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKI---GRLEKELENANDLLSAT 363
            ++   +  +E  +  + +Q    E+ + +D++E+E  + +    R+ +ELE ++  L   
Sbjct: 612  LQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL 671

Query: 364  KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL 423
            + K ++L++E +      + A  +                  +D L  EK E        
Sbjct: 672  EGKRSVLAKELVEVREALSRATLQ------------------RDMLQAEKAE-------- 705

Query: 424  DEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDT--DKANKQSSV 481
               V E   KA   +  R E E +   + +    L+ ++ ++  L E    DK +    V
Sbjct: 706  ---VAEALTKA---EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759

Query: 482  LERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541
             + +  +  +Q +    +    +   E+ R   +  ++EV+   +  S  V  Q      
Sbjct: 760  AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ---- 815

Query: 542  NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601
              E L+QQ   L            R E+     ++ +L  +L     ELEQ R+  Q Q+
Sbjct: 816  --EALEQQLPTL------------RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861

Query: 602  QLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIE 661
            + ++   R+++    L  +  G+A+ L A+  +  +L+    R    +     +   V  
Sbjct: 862  EALERAAREKEA---LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR 918

Query: 662  STEAIEAKAALKQL--------------------QEIFENYKKEKAENEKIQNEQLEKLQ 701
                +EA+    +                     Q+I    +K   + E +  + ++  +
Sbjct: 919  QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER 978

Query: 702  EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQK--LTATTQKQEQI 759
            E    LR Q       L    +  E     +E  R ++ S  +R Q+  L     ++E++
Sbjct: 979  EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL 1038

Query: 760  INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
               +    +  +E L +AE       ++++ L L E   +   E L+  +        +L
Sbjct: 1039 SEEIAALQQERDEGLLLAE------SEKQQALSLKESEKTALSEKLMGTRH-------SL 1085

Query: 820  QTIQGILERSETETKQRLS---SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT 876
             TI   +ER + + + R     S +  L  E+  L+ + E          R L  Q  D 
Sbjct: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDL 1145

Query: 877  KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
             +Q D+     L   E L+   + +   +  L   E+  A +  + + +G+   +++  +
Sbjct: 1146 GKQRDS----CLREAEELRTQLRLLEDARDGLRR-ELLEAQRKLRESQEGREVQRQEAGE 1200

Query: 937  LVSQLRQTEEQVNDLK---ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
            L   L +  ++   L+   E L+++    E  +  +    E   ++  + EE R  +   
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVG-- 1258

Query: 994  LKESAEFQT---QLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEV--- 1047
             KE+ E +T   ++E+  +E  +E QEL    RR ++ ++ + + L + L+ +Q  +   
Sbjct: 1259 -KEAGELRTGLQEVERSRLEARRELQEL----RRQMKMLDSENTRLGRELAELQGRLALG 1313

Query: 1048 --------QEALQRASTALSNE---QQARRDCQEQAKIAVEAQNKYE-RELMLHAADVEA 1095
                    +E L      L  E   +  R++ Q   +   E + ++  RE  L  +  EA
Sbjct: 1314 ERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373

Query: 1096 LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
                K+Q+     +   LE    +A    L   A+ E R + L+ E+++   +    E Q
Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAA-EGRAQGLEAELARVEVQRRAAEAQ 1432

Query: 1156 NRLLHDQIEK-------------------LSDKVVASVKEGVQGPLNVSLSEEGK----- 1191
               L   + +                     D       EG+  P  +  S   +     
Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492

Query: 1192 -----------------SQEQILEILRFIRREKEIAETRF-----EVAQVESLR--YRQR 1227
                             +  + L+ LR  +RE++   T+      ++A++E+ R     R
Sbjct: 1493 PATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSR 1552

Query: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE-----TMNVVMETNKMLREE 1282
               L++ + E +++  +   ++      +A  EE ++++E     T++ V    + L+  
Sbjct: 1553 ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQAT 1612

Query: 1283 KERL---EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA-- 1337
            +  L   ++ + +M+A   KLE D   L+E       ++  L+ +++ LE +++R +   
Sbjct: 1613 ESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGL 1672

Query: 1338 RNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNN-QNLI 1396
             ++   +Q      +  ++ +++ EV    +Q   E +    A++  S  +L +  + L 
Sbjct: 1673 SDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLT 1732

Query: 1397 QSLKED---LNKVRTEKETIQKDLDAKIID---IQEKVKTITQVKKIGRRYKTQY-EELK 1449
            ++L +    LN  R +   +QK L A   D   +QE++    Q     R+  +   E+++
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792

Query: 1450 AQQDKVMETSAQ---SSGDHQEQHVSVQEMQELK----ETLNQAETKSKSLESQVENLQK 1502
              + +V +   Q   + G  Q+    +++ QE +     T+ + + + + L+ ++ +LQ+
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852

Query: 1503 TLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQ-----QITEKEEKTRKAI 1557
             L++ E E R ++   ++L+ +   LR+ L     + E+LR      +++ ++ +  + +
Sbjct: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDK--VEREKLRSHEDTVRLSAEKGRLDRTL 1910

Query: 1558 VAAKSKIAHLAGVKDQLTKENEELKQRNGALD------QQKDELDVRITALKSQYEGRIS 1611
              A+ ++A       QL  +   L+Q +          QQ+ EL   +  L+S       
Sbjct: 1911 TGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTER 1970

Query: 1612 RLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASG 1654
             LE   R H++R     ++      ++ ++ R+ +   +P SG
Sbjct: 1971 TLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSG 2013



 Score = 36.2 bits (82), Expect = 0.39
 Identities = 37/155 (23%), Positives = 65/155 (41%), Gaps = 20/155 (12%)

Query: 1513 NLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAI---------VAAKSK 1563
            +LQE+   LQ ELSR+   L     + ++L  +     E+  +A+            +  
Sbjct: 78   SLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGL 137

Query: 1564 IAHLAGVKDQLTKENEELKQRNGAL---DQQKDELDVRITALKSQYEGRISRLERELREH 1620
            +     ++ QL +E    +++  A     Q++ +L  R+     QY+ R S LE++L E 
Sbjct: 138  VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197

Query: 1621 QERHLEQRDEPQEPSNKV--------PEQQRQITL 1647
                 +QR    E S  +         EQQR  +L
Sbjct: 198  SGELEQQRLRDTEHSQDLESALIRLEEEQQRSASL 232


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  175 bits (443), Expect = 5e-43
 Identities = 256/1207 (21%), Positives = 504/1207 (41%), Gaps = 185/1207 (15%)

Query: 389  VKPGMKLTELYNAYVETQDQLLL-----EKLEN--KRINKYLDEIVKEVEAKAPILKRQR 441
            VKP +++T         +D+L       +K EN  K + +   ++ +E       L+ + 
Sbjct: 841  VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900

Query: 442  EEYERAQKAVASLSVK---LEQAMKEIQ-RLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
            E Y  A++    L+ K   LE+ + E++ RL+E+ D+  +    L+ + ++M  Q+ DL 
Sbjct: 901  ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ----LQAERKKMAQQMLDLE 956

Query: 498  QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
            +Q+     E EEA    +  ++  + A I    + I   LV      +L ++ + L   +
Sbjct: 957  EQL-----EEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNKLSKERKLLEERI 1008

Query: 558  RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
             +L  T    E+E  +  +T+L+ K ES ++ELE   K  +   Q ++ + R+ +     
Sbjct: 1009 SDL--TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1061

Query: 618  LSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677
                 G A   H    D  +  +  K     +     A +  ++  E  +   ALK+++E
Sbjct: 1062 -----GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRE 1115

Query: 678  IF-------ENYKKEKAENEKIQNEQL---EKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
            +        E+   E+A   K + ++    E+L+   T+L       +TQ +  +KR + 
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175

Query: 728  LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
            +    +    E  S   + Q++    QK  Q +  +T+ L       A  +   + L+KE
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232

Query: 788  KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
               L      L Q ++ +  +++     +  LQ+     ER+  E    L+ ++ KL++E
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNE 1288

Query: 848  ISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
            +  +   L     +   L ++   L  QL DT+  L  ET   LN    L+  ++E  +L
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348

Query: 905  KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
            +  L                          D+ +   +  E  ++ L  +L  S   ++ 
Sbjct: 1349 QDQL--------------------------DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382

Query: 965  YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ---DD 1021
            + + V +LEE    +K+  +E+ +N+  + +E A    +LEK    +++E  +L    D+
Sbjct: 1383 FASTVEALEEG---KKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438

Query: 1022 KRRAIESMEQQLSELKKTLSSVQN---EVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
            +R+ + ++E++  +  + L+  +N   +  +   RA      ++          + A+EA
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498

Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERE--- 1135
            + + ER   +  A++E L ++K+ V K       LE++ +  E+Q+ E K   EE E   
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELEDEL 1555

Query: 1136 --------------RMLKDEVSKCV-CRCEDLEKQNRLLHDQI---------EKLSDKVV 1171
                          + LK +  + +  R E  E++ R L  Q+         E+    + 
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615

Query: 1172 ASVKEGVQGPL-NVSLSEEG--KSQEQILEILRFIR-------REKEIAETRFEVAQVES 1221
            A+ K+ ++G L ++ L  +   K +E+ ++ LR ++       RE E A    +     +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 1222 LRYRQRVELLERELQELQDSLNA-EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
                ++ + LE +L +LQ+ L A ER + Q   +     EEL       N + +  + L 
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 1281 EEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
                +LE++L++ Q  +           EA ++   K+   QAE+   E   +R  A+  
Sbjct: 1736 ARIAQLEEELEEEQGNM-----------EAMSDRVRKATQ-QAEQLSNELATERSTAQKN 1783

Query: 1341 HLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK 1400
                QQ +   +E R  L E E   K   +    I  L+A+IA+              L+
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQ--------------LE 1827

Query: 1401 EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA 1460
            E + +   EK+   K L  K   ++E +  +   +K+  +YK Q E+  A+         
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR--------- 1878

Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
                           +++LK  L +AE +S+ + +    LQ+ L E       +  +   
Sbjct: 1879 ---------------VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923

Query: 1521 LQSELSR 1527
            L+S+L R
Sbjct: 1924 LKSKLRR 1930



 Score =  174 bits (442), Expect = 7e-43
 Identities = 202/968 (20%), Positives = 418/968 (43%), Gaps = 135/968 (13%)

Query: 778  EVRAENLKKEKEMLKLSEVRLSQ--QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
            + + + L+K KE  + +E  L +  Q+ S L E++  NLL   LQ    +   +E E + 
Sbjct: 855  QAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--NLLQEQLQAETELYAEAE-EMRV 911

Query: 836  RLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RNLDVQLLDTKRQLDTETNLHLNTKE 892
            RL+++ ++LE  +  ++ +LE E ++   L    + +  Q+LD + QL+ E       + 
Sbjct: 912  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971

Query: 893  LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
                A+ +I  L+      E+ V    + +  K +   +E + DL + L + EE+  +L 
Sbjct: 972  EKVTAEAKIKKLED-----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL- 1025

Query: 953  ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK--------ESAEFQTQL 1004
                  T    ++++M++ LE  L KE++  +E+ K ++ +L+        + A+ Q Q+
Sbjct: 1026 ------TKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1078

Query: 1005 EKKLMEVEKEKQELQ----------------------------------DDKRRAIESME 1030
             +  M++ K+++ELQ                                  D +R A    E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138

Query: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--KIAVEAQNKYERELM- 1087
            +Q  +L + L +++ E+++ L   STA   E +A+R+ +     K   E    +E ++  
Sbjct: 1139 KQKRDLGEELEALKTELEDTLD--STATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196

Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ----------LLECKASWEERERM 1137
            +     +A++   EQ+ +    + +L++  Q  E +          L + K   E +++ 
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256

Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
            L+ +V +   +C D E+    L+D++ KL ++V     E V G LN +  +  K  + + 
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVA 1311

Query: 1198 EILRFIRREKEI--AETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ----- 1250
             +   ++  +E+   ETR      + L    ++  LE E   LQD L+ E E  Q     
Sbjct: 1312 SLSSQLQDTQELLQEETR------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 1251 ---VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
               +  +     ++L     T+  + E  K  ++E E L Q  ++  A   KLE     L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-----VSQQKDPDTEEYRKLLSEKE 1362
            Q+   EL +    L  +++L+    K+ +  +Q L     +S +   + +       EKE
Sbjct: 1426 QQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED-------LNKVRTEKETIQK 1415
                 + +  EE    K E+ R+N  L      + S K+D       L K +   ET  +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ-----H 1470
            ++  ++ +++++++     K    R +   + LK Q ++ ++   + + + + Q     H
Sbjct: 1543 EMKTQLEELEDELQATEDAK---LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
                E+++ ++    A    K LE  +++L+              +Q  +LQ+++   ++
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            +L+D     +++     E E+K       AKS  A L  +++ L       KQ +   ++
Sbjct: 1660 ELEDARASRDEIFATAKENEKK-------AKSLEADLMQLQEDLAAAERARKQADLEKEE 1712

Query: 1591 QKDELDVRITAL------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
              +EL   ++        K + E RI++LE EL E Q       D  ++ + +  +   +
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772

Query: 1645 ITLKTTPA 1652
            +  + + A
Sbjct: 1773 LATERSTA 1780



 Score =  174 bits (440), Expect = 1e-42
 Identities = 230/1081 (21%), Positives = 473/1081 (43%), Gaps = 150/1081 (13%)

Query: 673  KQLQEIFENYKKEKAENEKIQNEQLEKLQEQV---TDLRSQNTKISTQLDFASKRYEMLQ 729
            K+ Q+  EN  KE  +      E+   LQEQ+   T+L ++  ++  +L  A+K+ E L+
Sbjct: 865  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL--AAKKQE-LE 921

Query: 730  DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR---GANEKLAVAEVRAE-NLK 785
            + +      +    +R Q+L A  +K  Q +  + + L     A +KL + +V AE  +K
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981

Query: 786  K-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLT---------NLQTIQGILERSETETKQ 835
            K E E+L + +      +E  L E+R  +L            NL  ++   E   +E + 
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041

Query: 836  RLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL-----DTETNLHLNT 890
            RL  + EK   E+  LK+KLE +    H    +L  Q+ + K QL     + +  L    
Sbjct: 1042 RLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100

Query: 891  KELLK--NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
             E+ +  NA K+I  L+ H+S+++  + S+ + R  K +   ++  ++L +   + E+ +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARN-KAEKQKRDLGEELEALKTELEDTL 1159

Query: 949  NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL 1008
            +    + +      ++   +  +L+E     +   +E+R+     ++E  E   Q ++  
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219

Query: 1009 MEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC 1068
              ++K KQ L+ +       + + L + K+ +   + +++  +Q   +  S+ ++AR + 
Sbjct: 1220 ANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278

Query: 1069 QEQAKIAVEAQNKYEREL-MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
             ++     + QN+ E    ML+ A+ +A++ AK+ V+ ++S  Q  +E  Q+   Q L  
Sbjct: 1279 NDKVH---KLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNV 1334

Query: 1128 KASW---EERERMLKDEVSKCVCRCEDLEKQ----NRLLHDQIEKLSDKVVASVKEGVQG 1180
                   EE    L+D++ + +   ++LE+     N  L D  +KL D   AS  E +  
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD--FASTVEAL-- 1390

Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
                   EEGK + Q         +E E    ++E       +  +    L++EL +L  
Sbjct: 1391 -------EEGKKRFQ---------KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434

Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
             L+ +R+ V    K   + ++L+ + + ++          +E++R E + ++ + K   L
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALSL 1488

Query: 1301 ELDILPLQEANAELSEKSGMLQAEKKLL---EEDVKRWKARNQHLVSQQK---DPDTEEY 1354
               +    EA  EL   + ML+AE + L   ++DV     +N H + + K   +   EE 
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV----GKNVHELEKSKRALETQMEEM 1544

Query: 1355 RKLLSEKEVHTKRIQ----QLTEEIGRLKAEIARS-NASLTNNQNLIQSLKEDLNKVRTE 1409
            +  L E E   +  +    +L   +  LK +  R   A    N+   + L+  L++  TE
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604

Query: 1410 --------------KETIQKDL-------DAKIIDIQEKVKTITQVKKIGRRYKTQYEEL 1448
                          K+ ++ DL       D+ I   +E +K + +++   + ++ + E+ 
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664

Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQE------------------LKETL------- 1483
            +A +D++  T+ ++    +     + ++QE                  L E L       
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724

Query: 1484 NQAETKSKSLESQVENLQKTLSEKE-------TEARNLQEQTVQLQSELSRLRQDLQDRT 1536
            N  + + + LE+++  L++ L E++          R   +Q  QL +EL+  R   Q   
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784

Query: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKI--------AHLAGVKDQLTKENEELKQRNGAL 1588
            +  +QL +Q  E   K  +   A KSK         A +A +++Q+ +E  E +    +L
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844

Query: 1589 DQQKDELDVRITALKSQYEGRISRLERELREHQERHLE----QRDEPQEPSNKVPEQQRQ 1644
             Q+  +L  +   L+ + E +++   +E  E     ++    Q +E +E S ++   +R+
Sbjct: 1845 KQKDKKL--KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902

Query: 1645 I 1645
            +
Sbjct: 1903 L 1903



 Score =  172 bits (435), Expect = 5e-42
 Identities = 261/1190 (21%), Positives = 521/1190 (43%), Gaps = 180/1190 (15%)

Query: 112  QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD-ELQ 170
            Q TR +EE++A++ +L +T ER  +    L E  ++ ++  +E N  + +LQ + +   +
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 171  ASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK 230
            A ++ V+   K+ E E E+LH     L  E + +  +L A  ++   ++L+L+  LE  +
Sbjct: 906  AEEMRVRLAAKKQELE-EILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLE--E 961

Query: 231  EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK 290
            EE +R + Q+   K + E   K +ED +  + + +  + S E K   E     ++S+L  
Sbjct: 962  EEAARQKLQLE--KVTAEAKIKKLEDEILVMDD-QNNKLSKERKLLEE-----RISDLTT 1013

Query: 291  SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-L 349
            + A++ E K+  LT+   +   ++ E            LEV   K++  ++ LEK+ R L
Sbjct: 1014 NLAEEEE-KAKNLTKLKNKHESMISE------------LEVRLKKEEKSRQELEKLKRKL 1060

Query: 350  EKELENANDLLSATKRKGAIL------SEEEL-AAMSPTAAAVAKIVKPGMKLTELYNAY 402
            E +  + ++ ++  + + A L       EEEL AA++     +A+      K+ EL    
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120

Query: 403  VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
             + Q+ L  E+    +  K   ++ +E+EA    LK + E+   +      L  K EQ +
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEA----LKTELEDTLDSTATQQELRAKREQEV 1176

Query: 463  KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
              +++              L+ + R  E QV+++ Q+    + EL E      +   + +
Sbjct: 1177 TVLKK-------------ALDEETRSHEAQVQEMRQKHAQAVEELTEQ-----LEQFKRA 1218

Query: 523  SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QETTSSKITELQ 580
             A++              +N + L+++N  L   LR LG+ ++  E  ++   +++ ELQ
Sbjct: 1219 KANLD-------------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265

Query: 581  LKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVS 637
             K    E A  EL       Q++++ V            +L++  G AI L   + D  S
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL---AKDVAS 1312

Query: 638  LASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697
            L+S  +   T + +         E+ + +     L+QL+E   + + +  E    + E  
Sbjct: 1313 LSS--QLQDTQELLQE-------ETRQKLNVSTKLRQLEEERNSLQDQLDE----EMEAK 1359

Query: 698  EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
            + L+  ++ L  Q +    +L   +   E L++  + +++EI +L ++ ++  A   K E
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419

Query: 758  QIINTMTQDLRGANEKLAVAEVRAENLKKEK---EMLKLSEVRLS----QQRESLLAEQR 810
            +  N + Q+L      L        NL+K++   + L   E  +S     +R+   AE R
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479

Query: 811  GQNLLLTNL-QTIQGILERSE--TETKQRLSSQIEKL----------EHEISHLKKKLEN 857
             +     +L + ++  LE  E    T + L +++E L           HE+   K+ LE 
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 858  EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----------LKQ 906
            ++E+  T    L+ +L  T+   D +  L +N + L    ++++             L++
Sbjct: 1540 QMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596

Query: 907  HLSNMEVQVASQSSQRTGKGQPSNKEDVD----------------DLVSQLRQTEEQVND 950
             L   E ++  +  QR        K + D                + + QLR+ + Q+ D
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656

Query: 951  LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
             +  L+ + ++ ++  A  T+ E     +    + ++   ++   E A  Q  LEK+ + 
Sbjct: 1657 FQRELEDARASRDEIFA--TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714

Query: 1011 VE-----KEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
             E       +  LQD+KRR    I  +E++L E +  + ++ + V++A Q+A   LSNE 
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNEL 1773

Query: 1063 QARRDC---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK 1119
               R      E A+  +E QNK E    LH  +       K  ++ + +    LEE  ++
Sbjct: 1774 ATERSTAQKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832

Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
               +      S +++++ LK+     + + ED     R + +Q ++ ++K  A VK+   
Sbjct: 1833 EAREKQAATKSLKQKDKKLKE----ILLQVED----ERKMAEQYKEQAEKGNARVKQ--- 1881

Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQR 1227
              L   L E  +  ++I    R ++RE + A    E    +V +L+ + R
Sbjct: 1882 --LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score =  155 bits (391), Expect = 6e-37
 Identities = 242/1167 (20%), Positives = 486/1167 (41%), Gaps = 183/1167 (15%)

Query: 49   ESEQQYFEIE-KRLSHSQERLVNETRECQSLRLELEK----LNNQLKALTEKNKELEIAQ 103
            E E Q  E E ++    Q++  NE +E +    +L +    L  QL+A TE   E E  +
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910

Query: 104  DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
             R  A + +      E+EA   +     ++L  E + + + +  L E+L+E    + +LQ
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970

Query: 164  LKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGN 217
            L+        V+ + + K+LE E  ++  QN  L+ E K   + +      LA   EK  
Sbjct: 971  LE-------KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023

Query: 218  EILELKCNLEN---------KKEEVSR--LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
             + +LK   E+         KKEE SR  LE+    L+       + + DL  ++ E K 
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083

Query: 267  QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
            Q A  EE+    L           +  DD  A+ N   + + EL   + +  E      D
Sbjct: 1084 QLAKKEEELQAAL-----------ARLDDEIAQKNNALKKIRELEGHISDLQED----LD 1128

Query: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM-----SPT 381
                     ++ ++++ E++  L+ ELE+  D  +AT+++     E+E+  +       T
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEET 1187

Query: 382  AAAVAKIVKPGMKLTELYNAYVETQDQLLLEK---------LENKRIN-----KYLDEIV 427
             +  A++ +   K  +      E  +Q    K         LE +  +     + L +  
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247

Query: 428  KEVEAKAPILKRQREEYER----AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLE 483
            +EVE K   L+ Q +E +      ++A A L+ K+ +   E++ +    ++A  ++  L 
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 484  RDNRRMEIQVKDLSQ----------QIRVLLMELEEARGNHVIR-DEE----------VS 522
            +D   +  Q++D  +           +   L +LEE R +   + DEE          +S
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367

Query: 523  SADIS-SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL 581
            + +I  S S+   Q   S   +E L++  +R    +  L  T++ EE+     K+ + + 
Sbjct: 1368 TLNIQLSDSKKKLQDFAS--TVEALEEGKKRFQKEIENL--TQQYEEKAAAYDKLEKTKN 1423

Query: 582  KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
            +L+    EL+ L     +Q QLV ++ +++  +  LL++   ++    +   D+   A  
Sbjct: 1424 RLQQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS----SKYADERDRAEA 1476

Query: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
              R   ++ +S    +      EA+EAK      +E+    K  KAE E + + + + + 
Sbjct: 1477 EAREKETKALSLARAL-----EEALEAK------EELERTNKMLKAEMEDLVSSK-DDVG 1524

Query: 702  EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIIN 761
            + V +L      + TQ++    + E L+D ++                   T+  +  + 
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQ------------------ATEDAKLRLE 1566

Query: 762  TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
               Q L+G  E+    +++A + + E++  +L   R   + E+ L ++R Q  L      
Sbjct: 1567 VNMQALKGQFER----DLQARDEQNEEKRRQLQ--RQLHEYETELEDERKQRAL------ 1614

Query: 822  IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
                        K++L   ++ LE +     K  E  ++Q     R L  Q+ D +R+L+
Sbjct: 1615 --------AAAAKKKLEGDLKDLELQADSAIKGREEAIKQ----LRKLQAQMKDFQRELE 1662

Query: 882  TETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
                         K  +K+  +L+  L  M++Q    +++R  K     KE++ + ++  
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASS 1720

Query: 942  RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
                  + D K RL          +A +  LEE L +E+   E +   +    +++ +  
Sbjct: 1721 LSGRNALQDEKRRL----------EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN- 1060
             +L  +    +K +         A + +E+Q  EL+  L  ++  V+   +    AL   
Sbjct: 1771 NELATERSTAQKNES--------ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822

Query: 1061 ----EQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEAL-QAAKEQVSKMASVRQHL 1113
                E+Q  ++ +E+  A  +++ ++K  +E++L   D   + +  KEQ  K  +  + L
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882

Query: 1114 EETTQKAESQLLECKASWEERERMLKD 1140
            +   ++AE +     A+  + +R L +
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQRELDE 1909



 Score =  150 bits (379), Expect = 1e-35
 Identities = 237/1147 (20%), Positives = 481/1147 (41%), Gaps = 176/1147 (15%)

Query: 6    QQVLERTELNKLPKSVQNKLE----------KFLADQQSEIDGLKGRHEKFKVESEQQYF 55
            QQ+L+  E  +  ++ + KL+          K L D+   +D    +  K +   E++  
Sbjct: 950  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009

Query: 56   EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
            ++   L+  +E+  N T+        + +L  +LK   +  +ELE  + +     S F  
Sbjct: 1010 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069

Query: 116  TKEELEAE----KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
               +L+A+    K  L +  E L   L  L +++ + N  LK+      EL+  + +LQ 
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQE 1125

Query: 172  SDVSVKYREKRLEQEKELLHSQNTWLNTELK-----TKTDELLALGREKGNEILELKCNL 226
               S +    + E++K  L  +   L TEL+     T T + L   RE+  E+  LK  L
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKAL 1183

Query: 227  ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME------EKFHNELN 280
            +   EE    E Q+  ++   +H Q  VE+L  +L++ K  +A+++      EK + +L 
Sbjct: 1184 D---EETRSHEAQVQEMR--QKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237

Query: 281  AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
              +++      A  + E K  +L   V+EL     + GE  +A                 
Sbjct: 1238 GELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSD-GERARA----------------- 1276

Query: 341  EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
            E+ +K+ +L+ E+E+   +L+  + K AI   +++A++S       ++++          
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQE--------- 1326

Query: 401  AYVETQDQL----LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
               ET+ +L     L +LE +R N   D++ +E+EAK           +  ++ +++L++
Sbjct: 1327 ---ETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAK-----------QNLERHISTLNI 1371

Query: 457  KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI--RVLLMELEEARGNH 514
            +L  + K++Q      +        LE   +R + ++++L+QQ   +    +  E   N 
Sbjct: 1372 QLSDSKKKLQDFASTVE-------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 515  VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL----GETREREEQE 570
            + ++ +    D+ +  +++S       N+E+ Q++  +LL   + +     + R+R E E
Sbjct: 1425 LQQELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477

Query: 571  TTSSKITELQL--KLESALTELEQLRKSRQHQMQLVDSIVRQRD-----MYRILLS---- 619
                +   L L   LE AL   E+L ++ +     ++ +V  +D     ++ +  S    
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537

Query: 620  QTTGVAIPLHASSLDDVSLASTPKR---PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
            +T    +      L+D   A+   +       Q +       +    E  E K   +QLQ
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQ 1595

Query: 677  EIFENYKKEKAENEK---IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVE 733
                 Y+ E  +  K   +     +KL+  + DL  Q        + A K+   LQ  ++
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 734  GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
             ++RE+        ++ AT ++ E+   ++  DL    E LA AE   +    EKE L  
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-- 1713

Query: 794  SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
                     E L +   G+N L                + K+RL ++I +LE E+    +
Sbjct: 1714 --------AEELASSLSGRNAL---------------QDEKRRLEARIAQLEEEL----E 1746

Query: 854  KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
            + +  +E      R    Q      +L TE +           AQK   + +Q L     
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERS----------TAQKN-ESARQQLERQNK 1795

Query: 914  QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE 973
            ++ S+  +  G  +   K  +  L +++ Q EEQV       + +T +++Q    +  + 
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855

Query: 974  ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQL 1033
              +  E+++ E+ ++  E   K +A  + QL+++L E E+E Q +  ++R+    ++++L
Sbjct: 1856 LQVEDERKMAEQYKEQAE---KGNARVK-QLKRQLEEAEEESQRINANRRK----LQREL 1907

Query: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
             E  ++  ++  EV     ++     NE       +   +  +E  +  E E     AD 
Sbjct: 1908 DEATESNEAMGREVNAL--KSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADF 1965

Query: 1094 EALQAAK 1100
               +A++
Sbjct: 1966 NGTKASE 1972



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 154/799 (19%), Positives = 325/799 (40%), Gaps = 104/799 (13%)

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
            KV+   +   Q EE+  K + +    E  +    E + LEQ   Q+  +   L+  +   
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
             E  AE  E    L A+K+ LEE +   +AR +    + +    +  RK ++++ +  + 
Sbjct: 900  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE--EEDRGQQLQAERKKMAQQMLDLE- 956

Query: 1368 IQQLTEEIG---RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK---DLDAKI 1421
             +QL EE     +L+ E   + A +   ++ I  + +  NK+  E++ +++   DL   +
Sbjct: 957  -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015

Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQ-------QDKVMETSAQSSGDHQEQHVSVQ 1474
             + +EK K +T++K    ++++   EL+ +       + ++ +   +  GD  + H  + 
Sbjct: 1016 AEEEEKAKNLTKLK---NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1072

Query: 1475 EMQ----ELKETL---------------------NQAETKSKSLESQVENLQKTLSEKET 1509
            ++Q    ELK  L                     N A  K + LE  + +LQ+ L  +  
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132

Query: 1510 EARNLQEQTVQLQSELSRLRQDLQ---DRTTQEEQLR----QQIT----EKEEKTRKAIV 1558
                 ++Q   L  EL  L+ +L+   D T  +++LR    Q++T      +E+TR    
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192

Query: 1559 AAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL----------KSQYEG 1608
              +      A   ++LT++ E+ K+    LD+ K  L+     L          K + E 
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG----IASTSDP 1664
            +  +LE +++E Q +  +      E ++KV + Q ++   T   +   G    +A     
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 1665 PTANIKPTPVV---STPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTT 1721
             ++ ++ T  +    T  K+  +         R S++  +              + +   
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 1722 QVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQ 1781
              +S++ +Q          F ST  ++       Q  I    LT Q + +A A+    ++
Sbjct: 1373 LSDSKKKLQD---------FASTVEALEEGKKRFQKEIEN--LTQQYEEKAAAY-DKLEK 1420

Query: 1782 SHPQIEPANQELSSNIVEV-VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTI 1840
            +  +++   QEL   +V++  Q   V         F  + A    ++  +  +E + +  
Sbjct: 1421 TKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEA 1476

Query: 1841 EASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ 1900
            EA ++   +T  + L + L+       EE     +    E+E  V    S+D +G+ V +
Sbjct: 1477 EAREK---ETKALSLARALEEALE-AKEELERTNKMLKAEMEDLV---SSKDDVGKNVHE 1529

Query: 1901 GD------YTPMEDSEETSQSLQIDLGPLQSDQ-QTTTSSQDGQGKGDDVIVIDSDDEEE 1953
             +       T ME+ +   + L+ +L   +  + +   + Q  +G+ +  +    +  EE
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589

Query: 1954 DDDENDGEHEDYEEDEEDD 1972
               +   +  +YE + ED+
Sbjct: 1590 KRRQLQRQLHEYETELEDE 1608


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  175 bits (443), Expect = 5e-43
 Identities = 256/1207 (21%), Positives = 504/1207 (41%), Gaps = 185/1207 (15%)

Query: 389  VKPGMKLTELYNAYVETQDQLLL-----EKLEN--KRINKYLDEIVKEVEAKAPILKRQR 441
            VKP +++T         +D+L       +K EN  K + +   ++ +E       L+ + 
Sbjct: 848  VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907

Query: 442  EEYERAQKAVASLSVK---LEQAMKEIQ-RLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
            E Y  A++    L+ K   LE+ + E++ RL+E+ D+  +    L+ + ++M  Q+ DL 
Sbjct: 908  ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ----LQAERKKMAQQMLDLE 963

Query: 498  QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
            +Q+     E EEA    +  ++  + A I    + I   LV      +L ++ + L   +
Sbjct: 964  EQL-----EEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNKLSKERKLLEERI 1015

Query: 558  RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
             +L  T    E+E  +  +T+L+ K ES ++ELE   K  +   Q ++ + R+ +     
Sbjct: 1016 SDL--TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1068

Query: 618  LSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677
                 G A   H    D  +  +  K     +     A +  ++  E  +   ALK+++E
Sbjct: 1069 -----GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRE 1122

Query: 678  IF-------ENYKKEKAENEKIQNEQL---EKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
            +        E+   E+A   K + ++    E+L+   T+L       +TQ +  +KR + 
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182

Query: 728  LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
            +    +    E  S   + Q++    QK  Q +  +T+ L       A  +   + L+KE
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239

Query: 788  KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
               L      L Q ++ +  +++     +  LQ+     ER+  E    L+ ++ KL++E
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNE 1295

Query: 848  ISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
            +  +   L     +   L ++   L  QL DT+  L  ET   LN    L+  ++E  +L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355

Query: 905  KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
            +  L                          D+ +   +  E  ++ L  +L  S   ++ 
Sbjct: 1356 QDQL--------------------------DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389

Query: 965  YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ---DD 1021
            + + V +LEE    +K+  +E+ +N+  + +E A    +LEK    +++E  +L    D+
Sbjct: 1390 FASTVEALEEG---KKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445

Query: 1022 KRRAIESMEQQLSELKKTLSSVQN---EVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
            +R+ + ++E++  +  + L+  +N   +  +   RA      ++          + A+EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505

Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERE--- 1135
            + + ER   +  A++E L ++K+ V K       LE++ +  E+Q+ E K   EE E   
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELEDEL 1562

Query: 1136 --------------RMLKDEVSKCV-CRCEDLEKQNRLLHDQI---------EKLSDKVV 1171
                          + LK +  + +  R E  E++ R L  Q+         E+    + 
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622

Query: 1172 ASVKEGVQGPL-NVSLSEEG--KSQEQILEILRFIR-------REKEIAETRFEVAQVES 1221
            A+ K+ ++G L ++ L  +   K +E+ ++ LR ++       RE E A    +     +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 1222 LRYRQRVELLERELQELQDSLNA-EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
                ++ + LE +L +LQ+ L A ER + Q   +     EEL       N + +  + L 
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 1281 EEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
                +LE++L++ Q  +           EA ++   K+   QAE+   E   +R  A+  
Sbjct: 1743 ARIAQLEEELEEEQGNM-----------EAMSDRVRKATQ-QAEQLSNELATERSTAQKN 1790

Query: 1341 HLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK 1400
                QQ +   +E R  L E E   K   +    I  L+A+IA+              L+
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQ--------------LE 1834

Query: 1401 EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA 1460
            E + +   EK+   K L  K   ++E +  +   +K+  +YK Q E+  A+         
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR--------- 1885

Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
                           +++LK  L +AE +S+ + +    LQ+ L E       +  +   
Sbjct: 1886 ---------------VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930

Query: 1521 LQSELSR 1527
            L+S+L R
Sbjct: 1931 LKSKLRR 1937



 Score =  174 bits (442), Expect = 7e-43
 Identities = 202/968 (20%), Positives = 418/968 (43%), Gaps = 135/968 (13%)

Query: 778  EVRAENLKKEKEMLKLSEVRLSQ--QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
            + + + L+K KE  + +E  L +  Q+ S L E++  NLL   LQ    +   +E E + 
Sbjct: 862  QAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--NLLQEQLQAETELYAEAE-EMRV 918

Query: 836  RLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RNLDVQLLDTKRQLDTETNLHLNTKE 892
            RL+++ ++LE  +  ++ +LE E ++   L    + +  Q+LD + QL+ E       + 
Sbjct: 919  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978

Query: 893  LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
                A+ +I  L+      E+ V    + +  K +   +E + DL + L + EE+  +L 
Sbjct: 979  EKVTAEAKIKKLED-----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL- 1032

Query: 953  ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK--------ESAEFQTQL 1004
                  T    ++++M++ LE  L KE++  +E+ K ++ +L+        + A+ Q Q+
Sbjct: 1033 ------TKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1085

Query: 1005 EKKLMEVEKEKQELQ----------------------------------DDKRRAIESME 1030
             +  M++ K+++ELQ                                  D +R A    E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--KIAVEAQNKYERELM- 1087
            +Q  +L + L +++ E+++ L   STA   E +A+R+ +     K   E    +E ++  
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD--STATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ----------LLECKASWEERERM 1137
            +     +A++   EQ+ +    + +L++  Q  E +          L + K   E +++ 
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
            L+ +V +   +C D E+    L+D++ KL ++V     E V G LN +  +  K  + + 
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVA 1318

Query: 1198 EILRFIRREKEI--AETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ----- 1250
             +   ++  +E+   ETR      + L    ++  LE E   LQD L+ E E  Q     
Sbjct: 1319 SLSSQLQDTQELLQEETR------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 1251 ---VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
               +  +     ++L     T+  + E  K  ++E E L Q  ++  A   KLE     L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-----VSQQKDPDTEEYRKLLSEKE 1362
            Q+   EL +    L  +++L+    K+ +  +Q L     +S +   + +       EKE
Sbjct: 1433 QQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED-------LNKVRTEKETIQK 1415
                 + +  EE    K E+ R+N  L      + S K+D       L K +   ET  +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ-----H 1470
            ++  ++ +++++++     K    R +   + LK Q ++ ++   + + + + Q     H
Sbjct: 1550 EMKTQLEELEDELQATEDAK---LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
                E+++ ++    A    K LE  +++L+              +Q  +LQ+++   ++
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            +L+D     +++     E E+K       AKS  A L  +++ L       KQ +   ++
Sbjct: 1667 ELEDARASRDEIFATAKENEKK-------AKSLEADLMQLQEDLAAAERARKQADLEKEE 1719

Query: 1591 QKDELDVRITAL------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
              +EL   ++        K + E RI++LE EL E Q       D  ++ + +  +   +
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779

Query: 1645 ITLKTTPA 1652
            +  + + A
Sbjct: 1780 LATERSTA 1787



 Score =  174 bits (440), Expect = 1e-42
 Identities = 230/1081 (21%), Positives = 473/1081 (43%), Gaps = 150/1081 (13%)

Query: 673  KQLQEIFENYKKEKAENEKIQNEQLEKLQEQV---TDLRSQNTKISTQLDFASKRYEMLQ 729
            K+ Q+  EN  KE  +      E+   LQEQ+   T+L ++  ++  +L  A+K+ E L+
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL--AAKKQE-LE 928

Query: 730  DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR---GANEKLAVAEVRAE-NLK 785
            + +      +    +R Q+L A  +K  Q +  + + L     A +KL + +V AE  +K
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 786  K-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLT---------NLQTIQGILERSETETKQ 835
            K E E+L + +      +E  L E+R  +L            NL  ++   E   +E + 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048

Query: 836  RLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL-----DTETNLHLNT 890
            RL  + EK   E+  LK+KLE +    H    +L  Q+ + K QL     + +  L    
Sbjct: 1049 RLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 891  KELLK--NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
             E+ +  NA K+I  L+ H+S+++  + S+ + R  K +   ++  ++L +   + E+ +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARN-KAEKQKRDLGEELEALKTELEDTL 1166

Query: 949  NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL 1008
            +    + +      ++   +  +L+E     +   +E+R+     ++E  E   Q ++  
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 1009 MEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC 1068
              ++K KQ L+ +       + + L + K+ +   + +++  +Q   +  S+ ++AR + 
Sbjct: 1227 ANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285

Query: 1069 QEQAKIAVEAQNKYEREL-MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
             ++     + QN+ E    ML+ A+ +A++ AK+ V+ ++S  Q  +E  Q+   Q L  
Sbjct: 1286 NDKVH---KLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNV 1341

Query: 1128 KASW---EERERMLKDEVSKCVCRCEDLEKQ----NRLLHDQIEKLSDKVVASVKEGVQG 1180
                   EE    L+D++ + +   ++LE+     N  L D  +KL D   AS  E +  
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD--FASTVEAL-- 1397

Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
                   EEGK + Q         +E E    ++E       +  +    L++EL +L  
Sbjct: 1398 -------EEGKKRFQ---------KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441

Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
             L+ +R+ V    K   + ++L+ + + ++          +E++R E + ++ + K   L
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALSL 1495

Query: 1301 ELDILPLQEANAELSEKSGMLQAEKKLL---EEDVKRWKARNQHLVSQQK---DPDTEEY 1354
               +    EA  EL   + ML+AE + L   ++DV     +N H + + K   +   EE 
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV----GKNVHELEKSKRALETQMEEM 1551

Query: 1355 RKLLSEKEVHTKRIQ----QLTEEIGRLKAEIARS-NASLTNNQNLIQSLKEDLNKVRTE 1409
            +  L E E   +  +    +L   +  LK +  R   A    N+   + L+  L++  TE
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611

Query: 1410 --------------KETIQKDL-------DAKIIDIQEKVKTITQVKKIGRRYKTQYEEL 1448
                          K+ ++ DL       D+ I   +E +K + +++   + ++ + E+ 
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671

Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQE------------------LKETL------- 1483
            +A +D++  T+ ++    +     + ++QE                  L E L       
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731

Query: 1484 NQAETKSKSLESQVENLQKTLSEKE-------TEARNLQEQTVQLQSELSRLRQDLQDRT 1536
            N  + + + LE+++  L++ L E++          R   +Q  QL +EL+  R   Q   
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791

Query: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKI--------AHLAGVKDQLTKENEELKQRNGAL 1588
            +  +QL +Q  E   K  +   A KSK         A +A +++Q+ +E  E +    +L
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851

Query: 1589 DQQKDELDVRITALKSQYEGRISRLERELREHQERHLE----QRDEPQEPSNKVPEQQRQ 1644
             Q+  +L  +   L+ + E +++   +E  E     ++    Q +E +E S ++   +R+
Sbjct: 1852 KQKDKKL--KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909

Query: 1645 I 1645
            +
Sbjct: 1910 L 1910



 Score =  172 bits (435), Expect = 5e-42
 Identities = 261/1190 (21%), Positives = 521/1190 (43%), Gaps = 180/1190 (15%)

Query: 112  QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD-ELQ 170
            Q TR +EE++A++ +L +T ER  +    L E  ++ ++  +E N  + +LQ + +   +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 171  ASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK 230
            A ++ V+   K+ E E E+LH     L  E + +  +L A  ++   ++L+L+  LE  +
Sbjct: 913  AEEMRVRLAAKKQELE-EILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLE--E 968

Query: 231  EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK 290
            EE +R + Q+   K + E   K +ED +  + + +  + S E K   E     ++S+L  
Sbjct: 969  EEAARQKLQLE--KVTAEAKIKKLEDEILVMDD-QNNKLSKERKLLEE-----RISDLTT 1020

Query: 291  SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-L 349
            + A++ E K+  LT+   +   ++ E            LEV   K++  ++ LEK+ R L
Sbjct: 1021 NLAEEEE-KAKNLTKLKNKHESMISE------------LEVRLKKEEKSRQELEKLKRKL 1067

Query: 350  EKELENANDLLSATKRKGAIL------SEEEL-AAMSPTAAAVAKIVKPGMKLTELYNAY 402
            E +  + ++ ++  + + A L       EEEL AA++     +A+      K+ EL    
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127

Query: 403  VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
             + Q+ L  E+    +  K   ++ +E+EA    LK + E+   +      L  K EQ +
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEA----LKTELEDTLDSTATQQELRAKREQEV 1183

Query: 463  KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
              +++              L+ + R  E QV+++ Q+    + EL E      +   + +
Sbjct: 1184 TVLKK-------------ALDEETRSHEAQVQEMRQKHAQAVEELTEQ-----LEQFKRA 1225

Query: 523  SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QETTSSKITELQ 580
             A++              +N + L+++N  L   LR LG+ ++  E  ++   +++ ELQ
Sbjct: 1226 KANLD-------------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 581  LKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVS 637
             K    E A  EL       Q++++ V            +L++  G AI L   + D  S
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL---AKDVAS 1319

Query: 638  LASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697
            L+S  +   T + +         E+ + +     L+QL+E   + + +  E    + E  
Sbjct: 1320 LSS--QLQDTQELLQE-------ETRQKLNVSTKLRQLEEERNSLQDQLDE----EMEAK 1366

Query: 698  EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
            + L+  ++ L  Q +    +L   +   E L++  + +++EI +L ++ ++  A   K E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426

Query: 758  QIINTMTQDLRGANEKLAVAEVRAENLKKEK---EMLKLSEVRLS----QQRESLLAEQR 810
            +  N + Q+L      L        NL+K++   + L   E  +S     +R+   AE R
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486

Query: 811  GQNLLLTNL-QTIQGILERSE--TETKQRLSSQIEKL----------EHEISHLKKKLEN 857
             +     +L + ++  LE  E    T + L +++E L           HE+   K+ LE 
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 858  EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----------LKQ 906
            ++E+  T    L+ +L  T+   D +  L +N + L    ++++             L++
Sbjct: 1547 QMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

Query: 907  HLSNMEVQVASQSSQRTGKGQPSNKEDVD----------------DLVSQLRQTEEQVND 950
             L   E ++  +  QR        K + D                + + QLR+ + Q+ D
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 951  LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
             +  L+ + ++ ++  A  T+ E     +    + ++   ++   E A  Q  LEK+ + 
Sbjct: 1664 FQRELEDARASRDEIFA--TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721

Query: 1011 VE-----KEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
             E       +  LQD+KRR    I  +E++L E +  + ++ + V++A Q+A   LSNE 
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNEL 1780

Query: 1063 QARRDC---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK 1119
               R      E A+  +E QNK E    LH  +       K  ++ + +    LEE  ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
               +      S +++++ LK+     + + ED     R + +Q ++ ++K  A VK+   
Sbjct: 1840 EAREKQAATKSLKQKDKKLKE----ILLQVED----ERKMAEQYKEQAEKGNARVKQ--- 1888

Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQR 1227
              L   L E  +  ++I    R ++RE + A    E    +V +L+ + R
Sbjct: 1889 --LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  155 bits (391), Expect = 6e-37
 Identities = 242/1167 (20%), Positives = 486/1167 (41%), Gaps = 183/1167 (15%)

Query: 49   ESEQQYFEIE-KRLSHSQERLVNETRECQSLRLELEK----LNNQLKALTEKNKELEIAQ 103
            E E Q  E E ++    Q++  NE +E +    +L +    L  QL+A TE   E E  +
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917

Query: 104  DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
             R  A + +      E+EA   +     ++L  E + + + +  L E+L+E    + +LQ
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

Query: 164  LKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGN 217
            L+        V+ + + K+LE E  ++  QN  L+ E K   + +      LA   EK  
Sbjct: 978  LE-------KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030

Query: 218  EILELKCNLEN---------KKEEVSR--LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
             + +LK   E+         KKEE SR  LE+    L+       + + DL  ++ E K 
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 267  QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
            Q A  EE+    L           +  DD  A+ N   + + EL   + +  E      D
Sbjct: 1091 QLAKKEEELQAAL-----------ARLDDEIAQKNNALKKIRELEGHISDLQED----LD 1135

Query: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM-----SPT 381
                     ++ ++++ E++  L+ ELE+  D  +AT+++     E+E+  +       T
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEET 1194

Query: 382  AAAVAKIVKPGMKLTELYNAYVETQDQLLLEK---------LENKRIN-----KYLDEIV 427
             +  A++ +   K  +      E  +Q    K         LE +  +     + L +  
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 428  KEVEAKAPILKRQREEYER----AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLE 483
            +EVE K   L+ Q +E +      ++A A L+ K+ +   E++ +    ++A  ++  L 
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 484  RDNRRMEIQVKDLSQ----------QIRVLLMELEEARGNHVIR-DEE----------VS 522
            +D   +  Q++D  +           +   L +LEE R +   + DEE          +S
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374

Query: 523  SADIS-SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL 581
            + +I  S S+   Q   S   +E L++  +R    +  L  T++ EE+     K+ + + 
Sbjct: 1375 TLNIQLSDSKKKLQDFAS--TVEALEEGKKRFQKEIENL--TQQYEEKAAAYDKLEKTKN 1430

Query: 582  KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
            +L+    EL+ L     +Q QLV ++ +++  +  LL++   ++    +   D+   A  
Sbjct: 1431 RLQQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS----SKYADERDRAEA 1483

Query: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
              R   ++ +S    +      EA+EAK      +E+    K  KAE E + + + + + 
Sbjct: 1484 EAREKETKALSLARAL-----EEALEAK------EELERTNKMLKAEMEDLVSSK-DDVG 1531

Query: 702  EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIIN 761
            + V +L      + TQ++    + E L+D ++                   T+  +  + 
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQ------------------ATEDAKLRLE 1573

Query: 762  TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
               Q L+G  E+    +++A + + E++  +L   R   + E+ L ++R Q  L      
Sbjct: 1574 VNMQALKGQFER----DLQARDEQNEEKRRQLQ--RQLHEYETELEDERKQRAL------ 1621

Query: 822  IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
                        K++L   ++ LE +     K  E  ++Q     R L  Q+ D +R+L+
Sbjct: 1622 --------AAAAKKKLEGDLKDLELQADSAIKGREEAIKQ----LRKLQAQMKDFQRELE 1669

Query: 882  TETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
                         K  +K+  +L+  L  M++Q    +++R  K     KE++ + ++  
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASS 1727

Query: 942  RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
                  + D K RL          +A +  LEE L +E+   E +   +    +++ +  
Sbjct: 1728 LSGRNALQDEKRRL----------EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN- 1060
             +L  +    +K +         A + +E+Q  EL+  L  ++  V+   +    AL   
Sbjct: 1778 NELATERSTAQKNES--------ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829

Query: 1061 ----EQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEAL-QAAKEQVSKMASVRQHL 1113
                E+Q  ++ +E+  A  +++ ++K  +E++L   D   + +  KEQ  K  +  + L
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889

Query: 1114 EETTQKAESQLLECKASWEERERMLKD 1140
            +   ++AE +     A+  + +R L +
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQRELDE 1916



 Score =  150 bits (379), Expect = 1e-35
 Identities = 237/1147 (20%), Positives = 481/1147 (41%), Gaps = 176/1147 (15%)

Query: 6    QQVLERTELNKLPKSVQNKLE----------KFLADQQSEIDGLKGRHEKFKVESEQQYF 55
            QQ+L+  E  +  ++ + KL+          K L D+   +D    +  K +   E++  
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016

Query: 56   EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
            ++   L+  +E+  N T+        + +L  +LK   +  +ELE  + +     S F  
Sbjct: 1017 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076

Query: 116  TKEELEAE----KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
               +L+A+    K  L +  E L   L  L +++ + N  LK+      EL+  + +LQ 
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQE 1132

Query: 172  SDVSVKYREKRLEQEKELLHSQNTWLNTELK-----TKTDELLALGREKGNEILELKCNL 226
               S +    + E++K  L  +   L TEL+     T T + L   RE+  E+  LK  L
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKAL 1190

Query: 227  ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME------EKFHNELN 280
            +   EE    E Q+  ++   +H Q  VE+L  +L++ K  +A+++      EK + +L 
Sbjct: 1191 D---EETRSHEAQVQEMR--QKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244

Query: 281  AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
              +++      A  + E K  +L   V+EL     + GE  +A                 
Sbjct: 1245 GELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSD-GERARA----------------- 1283

Query: 341  EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
            E+ +K+ +L+ E+E+   +L+  + K AI   +++A++S       ++++          
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQE--------- 1333

Query: 401  AYVETQDQL----LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
               ET+ +L     L +LE +R N   D++ +E+EAK           +  ++ +++L++
Sbjct: 1334 ---ETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAK-----------QNLERHISTLNI 1378

Query: 457  KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI--RVLLMELEEARGNH 514
            +L  + K++Q      +        LE   +R + ++++L+QQ   +    +  E   N 
Sbjct: 1379 QLSDSKKKLQDFASTVE-------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 515  VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL----GETREREEQE 570
            + ++ +    D+ +  +++S       N+E+ Q++  +LL   + +     + R+R E E
Sbjct: 1432 LQQELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484

Query: 571  TTSSKITELQL--KLESALTELEQLRKSRQHQMQLVDSIVRQRD-----MYRILLS---- 619
                +   L L   LE AL   E+L ++ +     ++ +V  +D     ++ +  S    
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 620  QTTGVAIPLHASSLDDVSLASTPKR---PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
            +T    +      L+D   A+   +       Q +       +    E  E K   +QLQ
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQ 1602

Query: 677  EIFENYKKEKAENEK---IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVE 733
                 Y+ E  +  K   +     +KL+  + DL  Q        + A K+   LQ  ++
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 734  GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
             ++RE+        ++ AT ++ E+   ++  DL    E LA AE   +    EKE L  
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-- 1720

Query: 794  SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
                     E L +   G+N L                + K+RL ++I +LE E+    +
Sbjct: 1721 --------AEELASSLSGRNAL---------------QDEKRRLEARIAQLEEEL----E 1753

Query: 854  KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
            + +  +E      R    Q      +L TE +           AQK   + +Q L     
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERS----------TAQKN-ESARQQLERQNK 1802

Query: 914  QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE 973
            ++ S+  +  G  +   K  +  L +++ Q EEQV       + +T +++Q    +  + 
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862

Query: 974  ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQL 1033
              +  E+++ E+ ++  E   K +A  + QL+++L E E+E Q +  ++R+    ++++L
Sbjct: 1863 LQVEDERKMAEQYKEQAE---KGNARVK-QLKRQLEEAEEESQRINANRRK----LQREL 1914

Query: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
             E  ++  ++  EV     ++     NE       +   +  +E  +  E E     AD 
Sbjct: 1915 DEATESNEAMGREVNAL--KSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADF 1972

Query: 1094 EALQAAK 1100
               +A++
Sbjct: 1973 NGTKASE 1979



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 154/799 (19%), Positives = 325/799 (40%), Gaps = 104/799 (13%)

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
            KV+   +   Q EE+  K + +    E  +    E + LEQ   Q+  +   L+  +   
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
             E  AE  E    L A+K+ LEE +   +AR +    + +    +  RK ++++ +  + 
Sbjct: 907  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE--EEDRGQQLQAERKKMAQQMLDLE- 963

Query: 1368 IQQLTEEIG---RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK---DLDAKI 1421
             +QL EE     +L+ E   + A +   ++ I  + +  NK+  E++ +++   DL   +
Sbjct: 964  -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022

Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQ-------QDKVMETSAQSSGDHQEQHVSVQ 1474
             + +EK K +T++K    ++++   EL+ +       + ++ +   +  GD  + H  + 
Sbjct: 1023 AEEEEKAKNLTKLK---NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079

Query: 1475 EMQ----ELKETL---------------------NQAETKSKSLESQVENLQKTLSEKET 1509
            ++Q    ELK  L                     N A  K + LE  + +LQ+ L  +  
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139

Query: 1510 EARNLQEQTVQLQSELSRLRQDLQ---DRTTQEEQLR----QQIT----EKEEKTRKAIV 1558
                 ++Q   L  EL  L+ +L+   D T  +++LR    Q++T      +E+TR    
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199

Query: 1559 AAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL----------KSQYEG 1608
              +      A   ++LT++ E+ K+    LD+ K  L+     L          K + E 
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG----IASTSDP 1664
            +  +LE +++E Q +  +      E ++KV + Q ++   T   +   G    +A     
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 1665 PTANIKPTPVV---STPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTT 1721
             ++ ++ T  +    T  K+  +         R S++  +              + +   
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 1722 QVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQ 1781
              +S++ +Q          F ST  ++       Q  I    LT Q + +A A+    ++
Sbjct: 1380 LSDSKKKLQD---------FASTVEALEEGKKRFQKEIEN--LTQQYEEKAAAY-DKLEK 1427

Query: 1782 SHPQIEPANQELSSNIVEV-VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTI 1840
            +  +++   QEL   +V++  Q   V         F  + A    ++  +  +E + +  
Sbjct: 1428 TKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEA 1483

Query: 1841 EASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ 1900
            EA ++   +T  + L + L+       EE     +    E+E  V    S+D +G+ V +
Sbjct: 1484 EAREK---ETKALSLARALEEALE-AKEELERTNKMLKAEMEDLV---SSKDDVGKNVHE 1536

Query: 1901 GD------YTPMEDSEETSQSLQIDLGPLQSDQ-QTTTSSQDGQGKGDDVIVIDSDDEEE 1953
             +       T ME+ +   + L+ +L   +  + +   + Q  +G+ +  +    +  EE
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596

Query: 1954 DDDENDGEHEDYEEDEEDD 1972
               +   +  +YE + ED+
Sbjct: 1597 KRRQLQRQLHEYETELEDE 1615


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  174 bits (442), Expect = 7e-43
 Identities = 202/968 (20%), Positives = 418/968 (43%), Gaps = 135/968 (13%)

Query: 778  EVRAENLKKEKEMLKLSEVRLSQ--QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
            + + + L+K KE  + +E  L +  Q+ S L E++  NLL   LQ    +   +E E + 
Sbjct: 862  QAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--NLLQEQLQAETELYAEAE-EMRV 918

Query: 836  RLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RNLDVQLLDTKRQLDTETNLHLNTKE 892
            RL+++ ++LE  +  ++ +LE E ++   L    + +  Q+LD + QL+ E       + 
Sbjct: 919  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978

Query: 893  LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
                A+ +I  L+      E+ V    + +  K +   +E + DL + L + EE+  +L 
Sbjct: 979  EKVTAEAKIKKLED-----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL- 1032

Query: 953  ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK--------ESAEFQTQL 1004
                  T    ++++M++ LE  L KE++  +E+ K ++ +L+        + A+ Q Q+
Sbjct: 1033 ------TKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1085

Query: 1005 EKKLMEVEKEKQELQ----------------------------------DDKRRAIESME 1030
             +  M++ K+++ELQ                                  D +R A    E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--KIAVEAQNKYERELM- 1087
            +Q  +L + L +++ E+++ L   STA   E +A+R+ +     K   E    +E ++  
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD--STATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ----------LLECKASWEERERM 1137
            +     +A++   EQ+ +    + +L++  Q  E +          L + K   E +++ 
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
            L+ +V +   +C D E+    L+D++ KL ++V     E V G LN +  +  K  + + 
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVA 1318

Query: 1198 EILRFIRREKEI--AETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ----- 1250
             +   ++  +E+   ETR      + L    ++  LE E   LQD L+ E E  Q     
Sbjct: 1319 SLSSQLQDTQELLQEETR------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 1251 ---VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
               +  +     ++L     T+  + E  K  ++E E L Q  ++  A   KLE     L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-----VSQQKDPDTEEYRKLLSEKE 1362
            Q+   EL +    L  +++L+    K+ +  +Q L     +S +   + +       EKE
Sbjct: 1433 QQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED-------LNKVRTEKETIQK 1415
                 + +  EE    K E+ R+N  L      + S K+D       L K +   ET  +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ-----H 1470
            ++  ++ +++++++     K    R +   + LK Q ++ ++   + + + + Q     H
Sbjct: 1550 EMKTQLEELEDELQATEDAK---LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
                E+++ ++    A    K LE  +++L+              +Q  +LQ+++   ++
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
            +L+D     +++     E E+K       AKS  A L  +++ L       KQ +   ++
Sbjct: 1667 ELEDARASRDEIFATAKENEKK-------AKSLEADLMQLQEDLAAAERARKQADLEKEE 1719

Query: 1591 QKDELDVRITAL------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
              +EL   ++        K + E RI++LE EL E Q       D  ++ + +  +   +
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779

Query: 1645 ITLKTTPA 1652
            +  + + A
Sbjct: 1780 LATERSTA 1787



 Score =  174 bits (440), Expect = 1e-42
 Identities = 230/1081 (21%), Positives = 473/1081 (43%), Gaps = 150/1081 (13%)

Query: 673  KQLQEIFENYKKEKAENEKIQNEQLEKLQEQV---TDLRSQNTKISTQLDFASKRYEMLQ 729
            K+ Q+  EN  KE  +      E+   LQEQ+   T+L ++  ++  +L  A+K+ E L+
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL--AAKKQE-LE 928

Query: 730  DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR---GANEKLAVAEVRAE-NLK 785
            + +      +    +R Q+L A  +K  Q +  + + L     A +KL + +V AE  +K
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 786  K-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLT---------NLQTIQGILERSETETKQ 835
            K E E+L + +      +E  L E+R  +L            NL  ++   E   +E + 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048

Query: 836  RLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL-----DTETNLHLNT 890
            RL  + EK   E+  LK+KLE +    H    +L  Q+ + K QL     + +  L    
Sbjct: 1049 RLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 891  KELLK--NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
             E+ +  NA K+I  L+ H+S+++  + S+ + R  K +   ++  ++L +   + E+ +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARN-KAEKQKRDLGEELEALKTELEDTL 1166

Query: 949  NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL 1008
            +    + +      ++   +  +L+E     +   +E+R+     ++E  E   Q ++  
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 1009 MEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC 1068
              ++K KQ L+ +       + + L + K+ +   + +++  +Q   +  S+ ++AR + 
Sbjct: 1227 ANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285

Query: 1069 QEQAKIAVEAQNKYEREL-MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
             ++     + QN+ E    ML+ A+ +A++ AK+ V+ ++S  Q  +E  Q+   Q L  
Sbjct: 1286 NDKVH---KLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNV 1341

Query: 1128 KASW---EERERMLKDEVSKCVCRCEDLEKQ----NRLLHDQIEKLSDKVVASVKEGVQG 1180
                   EE    L+D++ + +   ++LE+     N  L D  +KL D   AS  E +  
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD--FASTVEAL-- 1397

Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
                   EEGK + Q         +E E    ++E       +  +    L++EL +L  
Sbjct: 1398 -------EEGKKRFQ---------KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441

Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
             L+ +R+ V    K   + ++L+ + + ++          +E++R E + ++ + K   L
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALSL 1495

Query: 1301 ELDILPLQEANAELSEKSGMLQAEKKLL---EEDVKRWKARNQHLVSQQK---DPDTEEY 1354
               +    EA  EL   + ML+AE + L   ++DV     +N H + + K   +   EE 
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV----GKNVHELEKSKRALETQMEEM 1551

Query: 1355 RKLLSEKEVHTKRIQ----QLTEEIGRLKAEIARS-NASLTNNQNLIQSLKEDLNKVRTE 1409
            +  L E E   +  +    +L   +  LK +  R   A    N+   + L+  L++  TE
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611

Query: 1410 --------------KETIQKDL-------DAKIIDIQEKVKTITQVKKIGRRYKTQYEEL 1448
                          K+ ++ DL       D+ I   +E +K + +++   + ++ + E+ 
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671

Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQE------------------LKETL------- 1483
            +A +D++  T+ ++    +     + ++QE                  L E L       
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731

Query: 1484 NQAETKSKSLESQVENLQKTLSEKE-------TEARNLQEQTVQLQSELSRLRQDLQDRT 1536
            N  + + + LE+++  L++ L E++          R   +Q  QL +EL+  R   Q   
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791

Query: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKI--------AHLAGVKDQLTKENEELKQRNGAL 1588
            +  +QL +Q  E   K  +   A KSK         A +A +++Q+ +E  E +    +L
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851

Query: 1589 DQQKDELDVRITALKSQYEGRISRLERELREHQERHLE----QRDEPQEPSNKVPEQQRQ 1644
             Q+  +L  +   L+ + E +++   +E  E     ++    Q +E +E S ++   +R+
Sbjct: 1852 KQKDKKL--KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909

Query: 1645 I 1645
            +
Sbjct: 1910 L 1910



 Score =  173 bits (439), Expect = 2e-42
 Identities = 255/1205 (21%), Positives = 503/1205 (41%), Gaps = 185/1205 (15%)

Query: 389  VKPGMKLTELYNAYVETQDQLLL-----EKLEN--KRINKYLDEIVKEVEAKAPILKRQR 441
            VKP +++T         +D+L       +K EN  K + +   ++ +E       L+ + 
Sbjct: 848  VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907

Query: 442  EEYERAQKAVASLSVK---LEQAMKEIQ-RLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
            E Y  A++    L+ K   LE+ + E++ RL+E+ D+  +    L+ + ++M  Q+ DL 
Sbjct: 908  ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ----LQAERKKMAQQMLDLE 963

Query: 498  QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
            +Q+     E EEA    +  ++  + A I    + I   LV      +L ++ + L   +
Sbjct: 964  EQL-----EEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNKLSKERKLLEERI 1015

Query: 558  RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
             +L  T    E+E  +  +T+L+ K ES ++ELE   K  +   Q ++ + R+ +     
Sbjct: 1016 SDL--TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1068

Query: 618  LSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677
                 G A   H    D  +  +  K     +     A +  ++  E  +   ALK+++E
Sbjct: 1069 -----GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRE 1122

Query: 678  IF-------ENYKKEKAENEKIQNEQL---EKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
            +        E+   E+A   K + ++    E+L+   T+L       +TQ +  +KR + 
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182

Query: 728  LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
            +    +    E  S   + Q++    QK  Q +  +T+ L       A  +   + L+KE
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239

Query: 788  KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
               L      L Q ++ +  +++     +  LQ+     ER+  E    L+ ++ KL++E
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNE 1295

Query: 848  ISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
            +  +   L     +   L ++   L  QL DT+  L  ET   LN    L+  ++E  +L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355

Query: 905  KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
            +  L                          D+ +   +  E  ++ L  +L  S   ++ 
Sbjct: 1356 QDQL--------------------------DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389

Query: 965  YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ---DD 1021
            + + V +LEE    +K+  +E+ +N+  + +E A    +LEK    +++E  +L    D+
Sbjct: 1390 FASTVEALEEG---KKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445

Query: 1022 KRRAIESMEQQLSELKKTLSSVQN---EVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
            +R+ + ++E++  +  + L+  +N   +  +   RA      ++          + A+EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505

Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERE--- 1135
            + + ER   +  A++E L ++K+ V K       LE++ +  E+Q+ E K   EE E   
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELEDEL 1562

Query: 1136 --------------RMLKDEVSKCV-CRCEDLEKQNRLLHDQI---------EKLSDKVV 1171
                          + LK +  + +  R E  E++ R L  Q+         E+    + 
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622

Query: 1172 ASVKEGVQGPL-NVSLSEEG--KSQEQILEILRFIR-------REKEIAETRFEVAQVES 1221
            A+ K+ ++G L ++ L  +   K +E+ ++ LR ++       RE E A    +     +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 1222 LRYRQRVELLERELQELQDSLNA-EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
                ++ + LE +L +LQ+ L A ER + Q   +     EEL       N + +  + L 
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 1281 EEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
                +LE++L++ Q  +           EA ++   K+   QAE+   E   +R  A+  
Sbjct: 1743 ARIAQLEEELEEEQGNM-----------EAMSDRVRKATQ-QAEQLSNELATERSTAQKN 1790

Query: 1341 HLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK 1400
                QQ +   +E R  L E E   K   +    I  L+A+IA+              L+
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQ--------------LE 1834

Query: 1401 EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA 1460
            E + +   EK+   K L  K   ++E +  +   +K+  +YK Q E+  A+         
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR--------- 1885

Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
                           +++LK  L +AE +S+ + +    LQ+ L E       +  +   
Sbjct: 1886 ---------------VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930

Query: 1521 LQSEL 1525
            L+S+L
Sbjct: 1931 LKSKL 1935



 Score =  172 bits (435), Expect = 5e-42
 Identities = 261/1190 (21%), Positives = 521/1190 (43%), Gaps = 180/1190 (15%)

Query: 112  QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD-ELQ 170
            Q TR +EE++A++ +L +T ER  +    L E  ++ ++  +E N  + +LQ + +   +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 171  ASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK 230
            A ++ V+   K+ E E E+LH     L  E + +  +L A  ++   ++L+L+  LE  +
Sbjct: 913  AEEMRVRLAAKKQELE-EILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLE--E 968

Query: 231  EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK 290
            EE +R + Q+   K + E   K +ED +  + + +  + S E K   E     ++S+L  
Sbjct: 969  EEAARQKLQLE--KVTAEAKIKKLEDEILVMDD-QNNKLSKERKLLEE-----RISDLTT 1020

Query: 291  SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-L 349
            + A++ E K+  LT+   +   ++ E            LEV   K++  ++ LEK+ R L
Sbjct: 1021 NLAEEEE-KAKNLTKLKNKHESMISE------------LEVRLKKEEKSRQELEKLKRKL 1067

Query: 350  EKELENANDLLSATKRKGAIL------SEEEL-AAMSPTAAAVAKIVKPGMKLTELYNAY 402
            E +  + ++ ++  + + A L       EEEL AA++     +A+      K+ EL    
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127

Query: 403  VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
             + Q+ L  E+    +  K   ++ +E+EA    LK + E+   +      L  K EQ +
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEA----LKTELEDTLDSTATQQELRAKREQEV 1183

Query: 463  KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
              +++              L+ + R  E QV+++ Q+    + EL E      +   + +
Sbjct: 1184 TVLKK-------------ALDEETRSHEAQVQEMRQKHAQAVEELTEQ-----LEQFKRA 1225

Query: 523  SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QETTSSKITELQ 580
             A++              +N + L+++N  L   LR LG+ ++  E  ++   +++ ELQ
Sbjct: 1226 KANLD-------------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 581  LKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVS 637
             K    E A  EL       Q++++ V            +L++  G AI L   + D  S
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL---AKDVAS 1319

Query: 638  LASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697
            L+S  +   T + +         E+ + +     L+QL+E   + + +  E    + E  
Sbjct: 1320 LSS--QLQDTQELLQE-------ETRQKLNVSTKLRQLEEERNSLQDQLDE----EMEAK 1366

Query: 698  EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
            + L+  ++ L  Q +    +L   +   E L++  + +++EI +L ++ ++  A   K E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426

Query: 758  QIINTMTQDLRGANEKLAVAEVRAENLKKEK---EMLKLSEVRLS----QQRESLLAEQR 810
            +  N + Q+L      L        NL+K++   + L   E  +S     +R+   AE R
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486

Query: 811  GQNLLLTNL-QTIQGILERSE--TETKQRLSSQIEKL----------EHEISHLKKKLEN 857
             +     +L + ++  LE  E    T + L +++E L           HE+   K+ LE 
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 858  EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----------LKQ 906
            ++E+  T    L+ +L  T+   D +  L +N + L    ++++             L++
Sbjct: 1547 QMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

Query: 907  HLSNMEVQVASQSSQRTGKGQPSNKEDVD----------------DLVSQLRQTEEQVND 950
             L   E ++  +  QR        K + D                + + QLR+ + Q+ D
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 951  LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
             +  L+ + ++ ++  A  T+ E     +    + ++   ++   E A  Q  LEK+ + 
Sbjct: 1664 FQRELEDARASRDEIFA--TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721

Query: 1011 VE-----KEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
             E       +  LQD+KRR    I  +E++L E +  + ++ + V++A Q+A   LSNE 
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNEL 1780

Query: 1063 QARRDC---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK 1119
               R      E A+  +E QNK E    LH  +       K  ++ + +    LEE  ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
               +      S +++++ LK+     + + ED     R + +Q ++ ++K  A VK+   
Sbjct: 1840 EAREKQAATKSLKQKDKKLKE----ILLQVED----ERKMAEQYKEQAEKGNARVKQ--- 1888

Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQR 1227
              L   L E  +  ++I    R ++RE + A    E    +V +L+ + R
Sbjct: 1889 --LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  161 bits (408), Expect = 6e-39
 Identities = 234/1174 (19%), Positives = 493/1174 (41%), Gaps = 174/1174 (14%)

Query: 229  KKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNL 288
            ++EE+   E+++   K   +  +  +++L  K  +  E++  ++E+   E   + +   +
Sbjct: 857  QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916

Query: 289  YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR 348
                A    AK  EL   + E+   L+E        +D   +++  + +M ++ML+    
Sbjct: 917  RVRLA----AKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLD---- 961

Query: 349  LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
            LE++LE                + ++L     TA A  K ++  + + +  N  +  + +
Sbjct: 962  LEEQLEEEE------------AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009

Query: 409  LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL 468
            LL E++ +   N      + E E KA  L + + ++E       S+  +LE  +K+ ++ 
Sbjct: 1010 LLEERISDLTTN------LAEEEEKAKNLTKLKNKHE-------SMISELEVRLKKEEKS 1056

Query: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
            +++ +K  ++   LE D      Q+ DL  QI  L M+L +       ++EE+ +A ++ 
Sbjct: 1057 RQELEKLKRK---LEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAA-LAR 1105

Query: 529  SSEVISQHLVSYRNIEELQ------QQNQRLLVALRELGETREREEQETTSSKITELQLK 582
              + I+Q   + + I EL+      Q++     A R   E ++R+  E   +  TEL+  
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165

Query: 583  LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP 642
            L+S  T+ ++LR  R+ ++ ++                           +LD+     T 
Sbjct: 1166 LDSTATQ-QELRAKREQEVTVLKK-------------------------ALDE----ETR 1195

Query: 643  KRPSTSQTVSTPAPVPVIESTEAIE----AKAALKQLQEIFENYKKEKAENEKIQNEQLE 698
               +  Q +       V E TE +E    AKA L + ++  E    + A   ++  +  +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255

Query: 699  KLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQ 758
            +++ +   L +Q  ++ ++     +    L D V   + E+ S+     +      K  +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315

Query: 759  IINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTN 818
             + +++  L+   E L   E   + L    ++ +L E R S Q + L  E   +  L  +
Sbjct: 1316 DVASLSSQLQDTQELLQ--EETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQNLERH 1372

Query: 819  LQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
            + T+   ++ S+++ K Q  +S +E LE      +K++EN  +Q        D +L  TK
Sbjct: 1373 ISTLN--IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD-KLEKTK 1429

Query: 878  RQLDTETNLHL----NTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
             +L  E +  +    N ++L+ N +K+     Q L+  E  ++S+ +    + +   +E 
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREK 1488

Query: 934  VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
                +S  R  EE + + KE L+ +   ++     + S ++ + K     E+ ++ +E +
Sbjct: 1489 ETKALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 994  LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
            ++E      +LE +L   E  K  L+ + +      E+ L    +     + ++Q  L  
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 1054 ASTALSNEQQAR--------------RDCQEQAKIAVEAQNK--------------YERE 1085
              T L +E++ R              +D + QA  A++ + +              ++RE
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667

Query: 1086 LM-LHAADVEALQAAKEQVSKMASVR---QHLEETTQKAE----------SQLLECKASW 1131
            L    A+  E    AKE   K  S+      L+E    AE           +L E  AS 
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727

Query: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV----SLS 1187
                  L+DE  +   R   LE++       +E +SD+V  + ++  Q    +    S +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787

Query: 1188 EEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247
            ++ +S  Q LE     R+ KE+     E+      +++  +  LE ++ +L++ +  E  
Sbjct: 1788 QKNESARQQLE-----RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKM-----------------LREEKERLEQDL 1290
            + Q   K++ Q ++ +K  E +  V +  KM                 L+ + E  E++ 
Sbjct: 1843 EKQAATKSLKQKDKKLK--EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 1291 QQMQAKVRKLELDILPLQEANAELSEKSGMLQAE 1324
            Q++ A  RKL+ ++    E+N  +  +   L+++
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score =  155 bits (391), Expect = 6e-37
 Identities = 242/1167 (20%), Positives = 486/1167 (41%), Gaps = 183/1167 (15%)

Query: 49   ESEQQYFEIE-KRLSHSQERLVNETRECQSLRLELEK----LNNQLKALTEKNKELEIAQ 103
            E E Q  E E ++    Q++  NE +E +    +L +    L  QL+A TE   E E  +
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917

Query: 104  DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
             R  A + +      E+EA   +     ++L  E + + + +  L E+L+E    + +LQ
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977

Query: 164  LKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGN 217
            L+        V+ + + K+LE E  ++  QN  L+ E K   + +      LA   EK  
Sbjct: 978  LE-------KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030

Query: 218  EILELKCNLEN---------KKEEVSR--LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
             + +LK   E+         KKEE SR  LE+    L+       + + DL  ++ E K 
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 267  QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
            Q A  EE+    L           +  DD  A+ N   + + EL   + +  E      D
Sbjct: 1091 QLAKKEEELQAAL-----------ARLDDEIAQKNNALKKIRELEGHISDLQED----LD 1135

Query: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM-----SPT 381
                     ++ ++++ E++  L+ ELE+  D  +AT+++     E+E+  +       T
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEET 1194

Query: 382  AAAVAKIVKPGMKLTELYNAYVETQDQLLLEK---------LENKRIN-----KYLDEIV 427
             +  A++ +   K  +      E  +Q    K         LE +  +     + L +  
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 428  KEVEAKAPILKRQREEYER----AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLE 483
            +EVE K   L+ Q +E +      ++A A L+ K+ +   E++ +    ++A  ++  L 
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 484  RDNRRMEIQVKDLSQ----------QIRVLLMELEEARGNHVIR-DEE----------VS 522
            +D   +  Q++D  +           +   L +LEE R +   + DEE          +S
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374

Query: 523  SADIS-SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL 581
            + +I  S S+   Q   S   +E L++  +R    +  L  T++ EE+     K+ + + 
Sbjct: 1375 TLNIQLSDSKKKLQDFAS--TVEALEEGKKRFQKEIENL--TQQYEEKAAAYDKLEKTKN 1430

Query: 582  KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
            +L+    EL+ L     +Q QLV ++ +++  +  LL++   ++    +   D+   A  
Sbjct: 1431 RLQQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS----SKYADERDRAEA 1483

Query: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
              R   ++ +S    +      EA+EAK      +E+    K  KAE E + + + + + 
Sbjct: 1484 EAREKETKALSLARAL-----EEALEAK------EELERTNKMLKAEMEDLVSSK-DDVG 1531

Query: 702  EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIIN 761
            + V +L      + TQ++    + E L+D ++                   T+  +  + 
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQ------------------ATEDAKLRLE 1573

Query: 762  TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
               Q L+G  E+    +++A + + E++  +L   R   + E+ L ++R Q  L      
Sbjct: 1574 VNMQALKGQFER----DLQARDEQNEEKRRQLQ--RQLHEYETELEDERKQRAL------ 1621

Query: 822  IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
                        K++L   ++ LE +     K  E  ++Q     R L  Q+ D +R+L+
Sbjct: 1622 --------AAAAKKKLEGDLKDLELQADSAIKGREEAIKQ----LRKLQAQMKDFQRELE 1669

Query: 882  TETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
                         K  +K+  +L+  L  M++Q    +++R  K     KE++ + ++  
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASS 1727

Query: 942  RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
                  + D K RL          +A +  LEE L +E+   E +   +    +++ +  
Sbjct: 1728 LSGRNALQDEKRRL----------EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN- 1060
             +L  +    +K +         A + +E+Q  EL+  L  ++  V+   +    AL   
Sbjct: 1778 NELATERSTAQKNES--------ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829

Query: 1061 ----EQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEAL-QAAKEQVSKMASVRQHL 1113
                E+Q  ++ +E+  A  +++ ++K  +E++L   D   + +  KEQ  K  +  + L
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889

Query: 1114 EETTQKAESQLLECKASWEERERMLKD 1140
            +   ++AE +     A+  + +R L +
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQRELDE 1916



 Score =  149 bits (377), Expect = 2e-35
 Identities = 229/1094 (20%), Positives = 464/1094 (42%), Gaps = 174/1094 (15%)

Query: 6    QQVLERTELNKLPKSVQNKLE----------KFLADQQSEIDGLKGRHEKFKVESEQQYF 55
            QQ+L+  E  +  ++ + KL+          K L D+   +D    +  K +   E++  
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016

Query: 56   EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
            ++   L+  +E+  N T+        + +L  +LK   +  +ELE  + +     S F  
Sbjct: 1017 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076

Query: 116  TKEELEAE----KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
               +L+A+    K  L +  E L   L  L +++ + N  LK+      EL+  + +LQ 
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQE 1132

Query: 172  SDVSVKYREKRLEQEKELLHSQNTWLNTELK-----TKTDELLALGREKGNEILELKCNL 226
               S +    + E++K  L  +   L TEL+     T T + L   RE+  E+  LK  L
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKAL 1190

Query: 227  ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME------EKFHNELN 280
            +   EE    E Q+  ++   +H Q  VE+L  +L++ K  +A+++      EK + +L 
Sbjct: 1191 D---EETRSHEAQVQEMR--QKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244

Query: 281  AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
              +++      A  + E K  +L   V+EL     + GE  +A                 
Sbjct: 1245 GELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSD-GERARA----------------- 1283

Query: 341  EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
            E+ +K+ +L+ E+E+   +L+  + K AI   +++A++S       ++++          
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQE--------- 1333

Query: 401  AYVETQDQL----LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
               ET+ +L     L +LE +R N   D++ +E+EAK           +  ++ +++L++
Sbjct: 1334 ---ETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAK-----------QNLERHISTLNI 1378

Query: 457  KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI--RVLLMELEEARGNH 514
            +L  + K++Q      +        LE   +R + ++++L+QQ   +    +  E   N 
Sbjct: 1379 QLSDSKKKLQDFASTVE-------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 515  VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL----GETREREEQE 570
            + ++ +    D+ +  +++S       N+E+ Q++  +LL   + +     + R+R E E
Sbjct: 1432 LQQELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484

Query: 571  TTSSKITELQL--KLESALTELEQLRKSRQHQMQLVDSIVRQRD-----MYRILLS---- 619
                +   L L   LE AL   E+L ++ +     ++ +V  +D     ++ +  S    
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 620  QTTGVAIPLHASSLDDVSLASTPKR---PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
            +T    +      L+D   A+   +       Q +       +    E  E K   +QLQ
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQ 1602

Query: 677  EIFENYKKEKAENEK---IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVE 733
                 Y+ E  +  K   +     +KL+  + DL  Q        + A K+   LQ  ++
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 734  GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
             ++RE+        ++ AT ++ E+   ++  DL    E LA AE   +    EKE L  
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-- 1720

Query: 794  SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
                     E L +   G+N L                + K+RL ++I +LE E+    +
Sbjct: 1721 --------AEELASSLSGRNAL---------------QDEKRRLEARIAQLEEEL----E 1753

Query: 854  KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
            + +  +E      R    Q      +L TE +           AQK   + +Q L     
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERS----------TAQKN-ESARQQLERQNK 1802

Query: 914  QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE 973
            ++ S+  +  G  +   K  +  L +++ Q EEQV       + +T +++Q    +  + 
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862

Query: 974  ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQL 1033
              +  E+++ E+ ++  E   K +A  + QL+++L E E+E Q +  ++R+    ++++L
Sbjct: 1863 LQVEDERKMAEQYKEQAE---KGNARVK-QLKRQLEEAEEESQRINANRRK----LQREL 1914

Query: 1034 SELKKTLSSVQNEV 1047
             E  ++  ++  EV
Sbjct: 1915 DEATESNEAMGREV 1928



 Score =  107 bits (268), Expect = 1e-22
 Identities = 197/942 (20%), Positives = 374/942 (39%), Gaps = 176/942 (18%)

Query: 19   KSVQNKLEKFLADQQSEIDGLK----------GRHEKFKVESEQQYFEIEKRL---SHSQ 65
            ++ +NK EK   D   E++ LK             ++ + + EQ+   ++K L   + S 
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 66   ERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKR 125
            E  V E R  Q     +E+L  QL    E+ K  +   D+N          K+ LE E  
Sbjct: 1198 EAQVQEMR--QKHAQAVEELTEQL----EQFKRAKANLDKN----------KQTLEKENA 1241

Query: 126  DL---IRTNERLSQELEY----LTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
            DL   +R   +  QE+E+    L   V+ L  K  +    + EL  K+ +LQ    SV  
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301

Query: 179  REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
                 E +   L      L+++L+  T ELL   +E+  + L +   L   +EE + L++
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQ-DTQELL---QEETRQKLNVSTKLRQLEEERNSLQD 1357

Query: 239  QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
            Q++    + ++L++H+  L  +L ++K+                 KL + + S  +  E 
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKK-----------------KLQD-FASTVEALEE 1399

Query: 299  KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
                  + +E L +  +E   A         ++E++K+++++E+ + +  L+ + +  ++
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYD-------KLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 359  LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKR 418
            L    ++   +L+EE+                       + + Y + +D+   E      
Sbjct: 1453 LEKKQRKFDQLLAEEK----------------------NISSKYADERDRAEAE------ 1484

Query: 419  INKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQ 478
                     +E E KA  L R  EE   A++ +   +  L+  M++   L    D   K 
Sbjct: 1485 --------AREKETKALSLARALEEALEAKEELERTNKMLKAEMED---LVSSKDDVGKN 1533

Query: 479  SSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLV 538
               LE+  R +E Q++++  Q       LEE      + DE  ++ D     EV      
Sbjct: 1534 VHELEKSKRALETQMEEMKTQ-------LEE------LEDELQATEDAKLRLEV------ 1574

Query: 539  SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQ 598
               N++ L+ Q +R L A  E  E + R           +LQ +L    TELE  RK R 
Sbjct: 1575 ---NMQALKGQFERDLQARDEQNEEKRR-----------QLQRQLHEYETELEDERKQRA 1620

Query: 599  HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA--------SSLDDVSLASTPKRPSTSQT 650
                    +  + D+  + L   + +     A        + + D        R S  + 
Sbjct: 1621 LAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678

Query: 651  VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTD---L 707
             +T          +A   +A L QLQE     ++ + + +  + E  E+L   ++    L
Sbjct: 1679 FATAKE----NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734

Query: 708  RSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT---ATTQKQEQIINTMT 764
            + +  ++  ++    +  E  Q N+E     +    ++ ++L+   AT +   Q   +  
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794

Query: 765  QDLRGANEKL--AVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL--- 819
            Q L   N++L   + E+      K K  +   E +++Q  E +  E R +     +L   
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854

Query: 820  -QTIQGILERSETETK--QRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT 876
             + ++ IL + E E K  ++   Q EK    +  LK++LE   E+   +  N        
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-------- 1906

Query: 877  KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
            +R+L  E +    + E +    +E+  LK  L     Q  SQ
Sbjct: 1907 RRKLQRELDEATESNEAM---GREVNALKSKLRGPPPQETSQ 1945



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 154/799 (19%), Positives = 325/799 (40%), Gaps = 104/799 (13%)

Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
            KV+   +   Q EE+  K + +    E  +    E + LEQ   Q+  +   L+  +   
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906

Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
             E  AE  E    L A+K+ LEE +   +AR +    + +    +  RK ++++ +  + 
Sbjct: 907  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE--EEDRGQQLQAERKKMAQQMLDLE- 963

Query: 1368 IQQLTEEIG---RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK---DLDAKI 1421
             +QL EE     +L+ E   + A +   ++ I  + +  NK+  E++ +++   DL   +
Sbjct: 964  -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022

Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQ-------QDKVMETSAQSSGDHQEQHVSVQ 1474
             + +EK K +T++K    ++++   EL+ +       + ++ +   +  GD  + H  + 
Sbjct: 1023 AEEEEKAKNLTKLK---NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079

Query: 1475 EMQ----ELKETL---------------------NQAETKSKSLESQVENLQKTLSEKET 1509
            ++Q    ELK  L                     N A  K + LE  + +LQ+ L  +  
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139

Query: 1510 EARNLQEQTVQLQSELSRLRQDLQ---DRTTQEEQLR----QQIT----EKEEKTRKAIV 1558
                 ++Q   L  EL  L+ +L+   D T  +++LR    Q++T      +E+TR    
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199

Query: 1559 AAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL----------KSQYEG 1608
              +      A   ++LT++ E+ K+    LD+ K  L+     L          K + E 
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG----IASTSDP 1664
            +  +LE +++E Q +  +      E ++KV + Q ++   T   +   G    +A     
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 1665 PTANIKPTPVV---STPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTT 1721
             ++ ++ T  +    T  K+  +         R S++  +              + +   
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 1722 QVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQ 1781
              +S++ +Q          F ST  ++       Q  I    LT Q + +A A+    ++
Sbjct: 1380 LSDSKKKLQD---------FASTVEALEEGKKRFQKEIEN--LTQQYEEKAAAY-DKLEK 1427

Query: 1782 SHPQIEPANQELSSNIVEV-VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTI 1840
            +  +++   QEL   +V++  Q   V         F  + A    ++  +  +E + +  
Sbjct: 1428 TKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEA 1483

Query: 1841 EASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ 1900
            EA ++   +T  + L + L+       EE     +    E+E  V    S+D +G+ V +
Sbjct: 1484 EAREK---ETKALSLARALEEALE-AKEELERTNKMLKAEMEDLV---SSKDDVGKNVHE 1536

Query: 1901 GD------YTPMEDSEETSQSLQIDLGPLQSDQ-QTTTSSQDGQGKGDDVIVIDSDDEEE 1953
             +       T ME+ +   + L+ +L   +  + +   + Q  +G+ +  +    +  EE
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596

Query: 1954 DDDENDGEHEDYEEDEEDD 1972
               +   +  +YE + ED+
Sbjct: 1597 KRRQLQRQLHEYETELEDE 1615



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 114/525 (21%), Positives = 227/525 (43%), Gaps = 48/525 (9%)

Query: 13   ELNKLPKSVQNKLEKFLAD---QQSEIDGLKGRHEKF-KVESEQQYFEIEKRLSHSQERL 68
            +L K    +Q +L+  + D   Q+  +  L+ +  KF ++ +E++   I  + +  ++R 
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRA 1481

Query: 69   VNETRECQSLRLELEK-LNNQLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEK 124
              E RE ++  L L + L   L+A   L   NK L+   +  ++ +    +   ELE  K
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 125  RDLIRTNERLSQELEYLTEDVKRLNE-KLK---ESNTTKGELQLKLDELQASDVSVKYRE 180
            R L    E +  +LE L ++++   + KL+        KG+ +    +LQA D   + + 
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKR 1598

Query: 181  KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGN-EILELKCNLENKKEE-----VS 234
            ++L+++   LH   T L  E K +     A  + +G+ + LEL+ +   K  E     + 
Sbjct: 1599 RQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 235  RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAAD 294
            +L+ QM   +   E  +   +++    KE +++  S+E     +L   +  +   +  AD
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM-QLQEDLAAAERARKQAD 1714

Query: 295  -DSEAKSNELTRA-----------------VEELHKLLKEAGEANKAIQDHLLEVEQSKD 336
             + E  + EL  +                 + +L + L+E     +A+ D + +  Q  +
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 337  QMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
            Q+  E+  +    +K       L    K   + L E E A  S   + +A +     +L 
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834

Query: 397  ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
            E        + Q   + L+ K  +K L EI+ +VE +  + ++ +E+ E+    V  L  
Sbjct: 1835 EQVEQEAR-EKQAATKSLKQK--DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891

Query: 457  KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIR 501
            +LE+A +E QR+  +  K  ++       N  M  +V  L  ++R
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.122    0.313 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,939,515
Number of Sequences: 37866
Number of extensions: 4250506
Number of successful extensions: 91455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1218
Number of HSP's successfully gapped in prelim test: 2217
Number of HSP's that attempted gapping in prelim test: 24146
Number of HSP's gapped (non-prelim): 29717
length of query: 2363
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2244
effective length of database: 13,741,464
effective search space: 30835845216
effective search space used: 30835845216
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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